National Library of Medicine (NCBI)
Lester, C. Edwards (Charles Edwards),
... Device of printer on t.p. v. 1. bk. 1. Introduction -- Bk. 2. The power and magnificence of the British Empire -- Bk. 3. Ireland : her woes and struggles under British ...
0000 - Gale Group | Sabin Jan-Jun 2013
Qiankun Chen, Leying Wang, Yuan Wei, Xizhan Xu, Guo Xiao-yan, Qingfeng Liang,
Purpose: Bacterial keratitis (BK) is a serious ocular infection that can cause severe inflammation and corneal scarring, leading to vision loss. In this ... the involvement of ferroptosis in the pathogenesis of BK. Methods: Transcriptome analysis was performed to evaluate ferroptosis-related gene expression in human BK corneas. Subsequently, the ferroptosis in mouse models of ... significant alterations in ferroptosis-related genes in human BK corneas. In the BK mouse models, the group treated with LEV+Fer- ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2024 - Cadmus Press | Investigative Ophthalmology & Visual Science
Murray, Hugh, Bradford, T. G. (Thomas Gamaliel), Wallace, William, Jameson, Robert, Hooker, William Jackson, Sir, Swainson, William,
... index. v. 1, pt. 1. History of geography. bk. 1, Ancient geography. bk. 2, Geography of the Middle Ages. bk. 3, Modern geography ; pt. 2. Principles of geography. ...
0000 - Gale Group | Sabin backfiles 2011
Anil Chandraker, Anil Regmi, Reginald Gohh, Akhil Sharma, E. Steve Woodle, Mohammed Javeed Ansari, Vinay Nair, Ling‐Xin Chen, Tarek Alhamad, Silas P. Norman, Diane M. Cibrik, Manpreet Singh, Arnold Alper, Divya Jain, Ziad Zaky, Stuart J. Knechtle, Asif Sharfuddin, Gaurav Gupta, Bonnie E. Lonze, Jo‐Anne H. Young, Deborah Adey, Arman Faravardeh, Darshana Dadhania, Ana P. Rossi, Diana F. Florescu, Francesca Cardarelli, Julie Ma, Sarah Gilmore, Spyridoula Vasileiou, Peter T. Jindra, David Wojciechowski,
... tolerated, and associated with a greater reduction of BK viremia compared with placebo. BK viremia reduction occurred coincident with an increase in the circulating frequency of BK virus–specific T cells in posoleucel recipients. The ... variable β sequencing. Background Kidney transplant recipients with BK virus infection are at risk of developing BK virus–associated nephropathy, allograft rejection, and subsequent graft loss. There are no approved treatments for BK virus infection. Posoleucel is an off-the-shelf, ...
Tópico(s): Polyomavirus and related diseases
2024 - American Society of Nephrology | Journal of the American Society of Nephrology
Murray, Hugh, Bradford, T. G. (Thomas Gamaliel), Wallace, William, Jameson, Robert, Hooker, William Jackson, Sir, Swainson, William,
... index. v. 1, pt. 1. History of geography. bk. 1, Ancient geography. bk. 2, Geography of the Middle Ages. bk. 3, Modern geography ; pt. 2. Principles of geography. ...
0000 - Gale Group | Sabin backfiles 2011
Mengnan Xu, Xi Zhong, Peng Huang, Dawid Jaślan, Pingping Wang, Xue Sun, Eva-Maria Weiden, Yassine El Hiani, Christian Grimm, Xian‐Ping Dong,
... report that big-conductance Ca 2+ -activated potassium (BK) channels form a positive feedback loop with TRPML3. Ca 2+ release via TRPML3 activates BK, which in turn facilitates TRPML3-mediated Ca 2+ ... luminal Na + inhibition. We further show that TRPML3/BK and mammalian target of rapamycin (mTOR) form another ... e., mTOR inhibition upon nutrient starvation activates TRPML3/BK, and this further reduces mTOR activity, thereby increasing autophagy induction. Mechanistically, the feedback regulation between TRPML3/BK and mTOR is mediated by PI3P, an endogenous ...
Tópico(s): Adenosine and Purinergic Signaling
2023 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Miscellaneous Free eBooks
Murray, Hugh, Bradford, T. G. (Thomas Gamaliel), Wallace, William, Jameson, Robert, Hooker, William Jackson, Sir, Swainson, William,
... index. v. 1, pt. 1. History of geography. bk. 1, Ancient geography. bk. 2, Geography of the Middle Ages. bk. 3, Modern geography ; pt. 2. Principles of geography. ...
0000 - Gale Group | Sabin backfiles 2011
Jian Gao, Hao Yin, Yanqun Dong, Xintong Wang, Yani Liu, KeWei Wang,
... in dose-dependent activation of macroscopic big potassium (BK) currents about 1.7- to 14.5-fold ... recordings. In single-channel recordings, benzbromarone decreases single BK α channel closed dwell time and increases the ... open probability. Coexpressing β 1 subunit also enhances BK activation by benzbromarone with an EC 50 of ... RCK) gating ring mediates the pharmacological activation of BK channels by benzbromarone. Further ex vivo assay shows ... together, our findings demonstrate that uricosuric benzbromarone activates BK channels through molecular mechanism of action involving the ...
Tópico(s): Coordination Chemistry and Organometallics
2023 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Miscellaneous Free eBooks
Vol. 1. bk. I. Historical sketch, introductory to the whole. bk. II. View of the geographical boundaries and natural history of British America. bk. III. Newfoundland. bk. IV. Prince Edward Island. bk. ...
0000 - Gale Group | Sabin
Hristo Gagov, И. В. Грибкова, V. N. Serebryakov, Rudolf Schubert,
... smooth muscle high-conductance, calcium-activated potassium channels (BK channels). There exist two hypotheses explaining the effect of NO and NO-donors on BK channels-one stating that protein kinase G (PKG) ... PKG to the NO-induced activation of the BK channel is still not completely clear. This study ... nitroprusside (SNP)-induced activation of vascular smooth muscle BK channels is fully mediated by PKG. This hypothesis ... the presence of iberiotoxin, the specific blocker of BK channels, during co-application with hydroxocobalamin, an NO- ...
Tópico(s): Neuroscience of respiration and sleep
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Miscellaneous Free eBooks
Edward, David B. (David Barnett),
Publisher's advertising: [2] p., 2nd count. bk. 1. Geographical delineations -- Bk. 2. General observations -- Bk. 3. Water of Texas -- Bk. 4. Timber lands -- Bk. 5. Climate -- Bk. 6. Savages -- Bk. ...
0000 - Gale Group | Sabin June 2012
Nicolas Tkatchenko, Alexander Romanyukha, Ricardo Reyes, Steven G Swarts, Didier Gourier, F. Trompier,
... with an endogenous signal called the background signal (BKS). RIS and BKS have similar spectral parameters. Therefore, detailed characterization of the BKS is required to develop a method for measuring ... of RIS by removing the signal due to BKS from the total spectrum of irradiated nails. Effects ... and oxidizing treatments of fingernail samples on the BKS were studied. Numerical simulations of the observed BKSs ... in fingernails are discussed. We also found that BKS can be generated in the fingernail clippings by ...
Tópico(s): Fungal Plant Pathogen Control
2022 - Springer Science+Business Media | Applied Magnetic Resonance
Miscellaneous Free eBooks
Includes index. bk. 1. An historical review of prison reform and child-saving work -- Bk. 2. The United States -- Bk. 3. Great Britain and her dependencies -- Bk. 4. ...
0000 - Gale Group | Sabin Jan-Jun 2013
Edith C. Bougouma, Nirianne Palacpac, Alfred B. Tiono, Issa Nébié, Alphonse Ouédraogo, Sophie Houard, Masanori Yagi, Sam Aboubacar Coulibaly, Amidou Diarra, Takahiro Tougan, Amidou Ouédraogo, Issiaka Soulama, Nobuko Arisue, Jean Baptiste Yaro, Flavia D’Alessio, Odile Leroy, Simon Cousens, Toshihiro Horii, Sodiomon B. Sirima,
... recombinant SE36 antigen formulated with aluminum hydroxyl gel (BK-SE36) was promising. This is the first time ... two vaccination routes. Methods Safety and immunogenicity of BK-SE36 was assessed in a double-blind, randomized, ... 1:1 ratio to receive three doses of BK-SE36 either by intramuscular (BK IM) or subcutaneous (BK SC) route on Day 0, Week 4, and ... experiencing Grade 3 adverse events was similar across BK-SE36 vaccines and control arms (Cohort 1: 100%, ... and Cohort 2: 83%, 82%, and 83% for BK IM, BK SC, and control, respectively). BK-SE36 ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2022 - Frontiers Media | Frontiers in Immunology
Johnson, William, Desty, Robert, Hopkins, Samuel Miles, Paige, Alonzo C. (Alonzo Christopher), Barbour, Oliver L. (Oliver Lorenzo), Edwards, Charles, Hoffman, Murray, Clarke, Charles L., Sandford, Lewis H. (Lewis Halsey),
... Two columns to the page. Includes bibliographical references. bk. 1. Johnson's Chancery reports, v. 1-5 -- Bk. 2. Johnson's Chancery reports, v. 6-7 ; ... 1 ; Paige's Chancery reports, v. 1-2 -- Bk. 3. Paige's Chancery reports, v. 3-6 -- ...
0000 - Gale Group | Sabin
Gaylene Pron, Matthew Hwang, Roger P. Smith, Angela Cheung, Kieran Murphy,
... procedures such as vertebroplasty (VP) or balloon kyphoplasty (BK) are increasingly employed to treat painful vertebral fractures ... evaluating cost-effectiveness of VA procedures, VP or BK for OVFs. Furthermore, assessments of quality (risk of ... reporting cost-effectiveness for VA procedures, VP or BK for OVFsOUTCOME MEASURESThe following information extracted from the ... effectiveness analyses on VA procedures including VP or BK for OVFs. Studies including only costs, abstracts, editorials, ... cost-effectiveness studies, three for VP, three for BK and four for both VP and BK, all ...
Tópico(s): Hip and Femur Fractures
2022 - Elsevier BV | The Spine Journal
Miscellaneous Free eBooks
Johnson, William, Desty, Robert, Hopkins, Samuel Miles, Paige, Alonzo C. (Alonzo Christopher), Barbour, Oliver L. (Oliver Lorenzo), Edwards, Charles, Hoffman, Murray, Clarke, Charles L., Sandford, Lewis H. (Lewis Halsey),
... Two columns to the page. Includes bibliographical references. bk. 1. Johnson's Chancery reports, v. 1-5 -- Bk. 2. Johnson's Chancery reports, v. 6-7 ; ... 1 ; Paige's Chancery reports, v. 1-2 -- Bk. 3. Paige's Chancery reports, v. 3-6 -- ...
0000 - Gale Group | Sabin
Su Mi Park, Cooper E. Roache, Philip H. Iffland, Hans Moldenhauer, Katia K. Matychak, Amber E. Plante, Abby G. Lieberman, Peter B. Crino, Andrea L. Meredith,
KCNMA1 forms the pore of BK K + channels, which regulate neuronal and muscle excitability. Recently, genetic screening identified heterozygous KCNMA1 variants in a subset of patients with ... relative severity of three KCNMA1 patient variants in BK channels, neurons, and mice. In heterologous cells, BK N999S and BK D434G channels displayed gain-of-function (GOF) properties, whereas BK H444Q channels showed loss-of-function (LOF) properties. The relative degree of channel activity was BK N999S > BK D434G >WT > BK H444Q . BK currents ...
Tópico(s): Bipolar Disorder and Treatment
2022 - eLife Sciences Publications Ltd | eLife
Miscellaneous Free eBooks
Johnson, William, Desty, Robert, Hopkins, Samuel Miles, Paige, Alonzo C. (Alonzo Christopher), Barbour, Oliver L. (Oliver Lorenzo), Edwards, Charles, Hoffman, Murray, Clarke, Charles L., Sandford, Lewis H. (Lewis Halsey),
... Two columns to the page. Includes bibliographical references. bk. 1. Johnson's Chancery reports, v. 1-5 -- Bk. 2. Johnson's Chancery reports, v. 6-7 ; ... 1 ; Paige's Chancery reports, v. 1-2 -- Bk. 3. Paige's Chancery reports, v. 3-6 -- ...
0000 - Gale Group | Sabin
Chao Yang, Zihao Yang, Kuiyuan Tong, Jiawei Wang, Wanli Yang, Ruihua Yu, Feng Jiang, Yong-Hua Ji,
Large conductance calcium-activated potassium channel (BK channel) is gated by both voltage and calcium ions and is widely distributed in excitable and nonexcitable cells. BK channel plays an important role in epilepsy and other diseases, but BK channel subtype-specific drugs are still extremely rare. ... that the pharmacological selectivity of martentoxin to the BK channel is higher than that to other potassium ... study the mechanism of interaction between martentoxin and BK channels.The three-dimensional structure of BK channel ...
Tópico(s): Venomous Animal Envenomation and Studies
2022 - AME Publishing Company | Annals of Translational Medicine