Merryn Voysey, Sue Ann Costa Clemens, Shabir A. Madhi, Lily Yin Weckx, Pedro M. Folegatti, Parvinder K. Aley, Brian Angus, Vicky L. Baillie, Shaun Barnabas, Qasim Bhorat, Sagida Bibi, Carmen Briner, Paola Cicconi, Andrea M. Collins, Rachel Colin-Jones, Clare Cutland, Thomas C. Darton, Keertan Dheda, C.J. Duncan, Katherine R. W. Emary, Katie Ewer, Lee Fairlie, Saul N. Faust, Shuo Feng, Daniela M. Ferreira, Adam Finn, Anna L. Goodman, Catherine Green, Christopher Green, Paul T. Heath, Catherine Hill, Helen Hill, Ian Hirsch, Susanne H. Hodgson, Alane Izu, Susan Jackson, Daniel Jenkin, Carina C. D. Joe, Simon Kerridge, Anthonet Koen, Gaurav Kwatra, Rajeka Lazarus, Alison M. Lawrie, Alice Lelliott, Vincenzo Libri, Patrick Lillie, Raburn M. Mallory, Ana Verena Almeida Mendes, Eveline Pı́polo Milan, Angela M. Minassian, Alastair McGregor, Hazel Morrison, Yama F Mujadidi, Anusha Nana, Peter O’Reilly, Sherman D. Padayachee, Ana Pittella, Emma Plested, Katrina M. Pollock, Maheshi Ramasamy, Sarah Rhead, Alexandre Vargas Schwarzbold, Nisha Singh, Darren Smith, Rinn Song, Matthew D. Snape, Eduardo Sprinz, Rebecca Sutherland, Richard Tarrant, Emma C. Thomson, M. Estée Török, Mark Toshner, David P. J. Turner, Johan Vekemans, Tonya Villafana, Marion Watson, Christopher J. Williams, Alexander D. Douglas, Adrian V. S. Hill, Teresa Lambe, Sarah C. Gilbert, Andrew J. Pollard, Marites Aban, Fatola Abayomi, Kushala W.M. Abeyskera, Jeremy Aboagye, Matthew Adam, Kirsty Adams, James P. Adamson, Yemi Adelaja, Gbadebo Adewetan, Syed Adlou, Khatija Ahmed, Yasmeen Akhalwaya, Saajida Akhalwaya, Andrew Alcock, Aabidah Ali, Elizabeth Allen, Lauren Allen, Thamires C. D. S. C Almeida, Mariana Alves, Fábio Ferreira Amorim, Foteini Andritsou, Rachel Anslow, Matthew Appleby, Edward H. Arbe-Barnes, Mark P. Ariaans, Beatriz Arns, Laiana Arruda, Paula De Almeida Azi, Lorena De Almeida Azi, Gavin Babbage, Catherine Bailey, Kenneth F. Baker, Megan Baker, Natalie Baker, Philip Baker, Lisa Baldwin, Ioana Baleanu, Danieli Bandeira, Anna Bara, Marcella A.S. Barbosa, Debbie Barker, Gavin Barlow, Eleanor Barnes, Andrew Barr, Jordan R. Barrett, Jessica Barrett, Louise Bates, Alexander Batten, Kirsten Beadon, Emily Beales, Rebecca Beckley, Sandra Belij‐Rammerstorfer, Jonathan Bell, Duncan Bellamy, Nancy Bellei, Sue Belton, Adam Berg, Laura M. Bermejo, Eleanor Berrie, Lisa Berry, Daniella Berzenyi, Amy Beveridge, Kevin R. Bewley, Helen Bexhell, Sutika Bhikha, As’ad E. Bhorat, Zaheda E. Bhorat, Else M. Bijker, Geeta Birch, Sarah Birch, Adam R Bird, Olivia Bird, Karen Bisnauthsing, Mustapha Bittaye, K. Blackstone, Luke Blackwell, Heather Bletchly, Caitlin L. Blundell, Susannah R. Blundell, Pritesh Bodalia, Bruno Cruz Boettger, Emma Bolam, Elena Boland, Daan Bormans, Nicola Borthwick, Francesca Bowring, Amy Boyd, Penny Bradley, Tanja Brenner, Phillip J. Brown, Claire Brown, Charlie Brown-O’Sullivan, S Bruce, Emily Brunt, Ruaridh Buchan, William Budd, Yusuf A. Bulbulia, Melanie Bull, Jamie Burbage, Hassan Burhan, Aileen Burn, Karen R. Buttigieg, Nicholas Byard, Ingrid Cabera Puig, Gloria Calderón, Anna Calvert, Susana Camara, Michelangelo Cao, Federica Cappuccini, João C. R. Cardoso, Melanie Carr, Miles W. Carroll, Andrew Carson‐Stevens, Yasmin de M. Carvalho, José Antônio Mainardi de Carvalho, Helen R. Casey, Paul Cashen, Thaís Castro Ribeiro, Lucía Carratalá-Castro, Katrina Cathie, Ana Cavey, José Cerbino-Neto, Jim Chadwick, David Chapman, Sue Charlton, Irina Chelysheva, Oliver Chester, Sunder Chita, Jee-Sun Cho, Liliana Cifuentes, Elizabeth Clark, Matthew Clark, Andrea Clarke, Elizabeth Clutterbuck, Sarah L.K. Collins, Christopher P. Conlon, Sean Connarty, Naomi S. Coombes, Cushla Cooper, Rachel Cooper, Lynne Cornelissen, Tumena Corrah, Catherine Cosgrove, Tony Cox, Wendy E.M. Crocker, Sarah Crosbie, Lorraine Cullen, Dan Cullen, Debora R.M.F. Cunha, Christina J. Cunningham, Fiona C. Cuthbertson, Suzete Nascimento Farias da Guarda, Larissa P. da Silva, Brad E. Damratoski, Zsofia Danos, Maria T.D.C. Dantas, Paula Darroch, Mehreen S. Datoo, Chandrabali Datta, Malika Davids, Sarah L. Davies, H. Dele Davies, Elizabeth J. Davis, Judith A. Davis, John D. Davis, Maristela Miyamoto de Nobrega, Lis Moreno De Oliveira Kalid, David J. Dearlove, Tesfaye Demissie, Amisha Desai, Stefania Di Marco, Claudio Di Maso, Maria Isabel Saraiva Dinelli, Tanya Dinesh, Claire Docksey, Christina Dold, Tao Dong, Francesca R. Donnellan, Tannyth Dos Santos, Thainá G. dos Santos, Erika Pachecho Dos Santos, Naomi Douglas, Charlotte Downing, Jonathan Drake, Rachael Drake-Brockman, Kimberley Driver, Ruth Drury, Susanna Dunachie, Benjamin Durham, Lidiana Dutra, Nicholas Easom, Samual van Eck, Mandy Edwards, Nick J. Edwards, Omar M. El Muhanna, Sean C. Elias, Mike Elmore, Marcus Rex English, Alisgair Esmail, Yakub Moosa Essack, Eoghan C. W. Farmer, Mutjaba Farooq, Madi Farrar, Leonard Farrugia, Beverley Faulkner, Sofiya Fedosyuk, Sally Felle, Shuo Feng, Carla Ferreira Da Silva, Samantha Field, Richard Fisher, Amy Flaxman, James L. K. Fletcher, Hazel Fofie,
SummaryBackgroundA safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.MethodsThis analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly ...
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Merryn Voysey, Sue Ann Costa Clemens, Shabir A. Madhi, Lily Yin Weckx, Pedro M. Folegatti, Parvinder K. Aley, Brian Angus, Vicky L. Baillie, Shaun Barnabas, Qasim Bhorat, Sagida Bibi, Carmen Briner, Paola Cicconi, Elizabeth Clutterbuck, Andrea M. Collins, Clare Cutland, Thomas C. Darton, Keertan Dheda, Christina Dold, C.J. Duncan, Katherine R. W. Emary, Katie Ewer, Amy Flaxman, Lee Fairlie, Saul N. Faust, Shuo Feng, Daniela M. Ferreira, Adam Finn, Eva Galiza, Anna L. Goodman, Catherine Green, Christopher Green, Melanie Greenland, Catherine Hill, Helen Hill, Ian Hirsch, Alane Izu, Daniel Jenkin, Carina C. D. Joe, Simon Kerridge, Anthonet Koen, Gaurav Kwatra, Rajeka Lazarus, Vincenzo Libri, Patrick Lillie, Natalie G. Marchevsky, Richard P. Marshall, Ana Verena Almeida Mendes, Eveline Pı́polo Milan, Angela M. Minassian, Alastair McGregor, Yama F Mujadidi, Anusha Nana, Sherman D. Padayachee, Daniel J. Phillips, Ana Pittella, Emma Plested, Katrina M. Pollock, Maheshi Ramasamy, Adam Ritchie, Hannah Robinson, Alexandre Vargas Schwarzbold, Darren Smith, Rinn Song, Matthew D. Snape, Eduardo Sprinz, Rebecca Sutherland, Emma C. Thomson, M. Estée Török, Mark Toshner, David P. J. Turner, Johan Vekemans, Tonya Villafana, Thomas White, Christopher J. Williams, Alexander D. Douglas, Adrian V. S. Hill, Teresa Lambe, Sarah C. Gilbert, Andrew J. Pollard, Marites Aban, Kushala W.M. Abeyskera, Jeremy Aboagye, Matthew Adam, Kirsty Adams, James P. Adamson, Gbadebo Adewatan, Syed Adlou, Khatija Ahmed, Yasmeen Akhalwaya, Saajida Akhalwaya, Andrew Alcock, Aabidah Ali, Elizabeth Allen, Lauren Allen, Felipe B. Alvernaz, Fabio Santos Amorim, Claudia Sala Andrade, Foteini Andritsou, Rachel Anslow, Edward H. Arbe-Barnes, Mark P. Ariaans, Beatriz Arns, Laiana Arruda, Luiza Assad, Paula De Almeida Azi, Lorena De Almeida Azi, Gavin Babbage, Catherine Bailey, Kenneth F. Baker, Megan Baker, Natalie Baker, Philip Baker, Ioana Baleanu, Danieli Bandeira, Anna Bara, Marcella A.S. Barbosa, Debbie Barker, Gavin Barlow, Eleanor Barnes, Andrew Barr, Jordan R. Barrett, Jessica Barrett, Kelly M. Schiabor Barrett, Louise Bates, Alexander Batten, Kirsten Beadon, Emily Beales, Rebecca Beckley, Sandra Belij‐Rammerstorfer, Jonathan Bell, Duncan Bellamy, Sue Belton, Adam Berg, Laura M. Bermejo, Eleanor Berrie, Lisa Berry, Daniella Berzenyi, Amy Beveridge, Kevin R. Bewley, INDERJEET BHARAJ, Sutika Bhikha, As’ad E. Bhorat, Zaheda E. Bhorat, Else M. Bijker, Sarah Birch, Gurpreet Birch, Kathryn Birchall, Adam R Bird, Olivia Bird, Karen Bisnauthsing, Mustapha Bittaye, Luke Blackwell, Rachel Blacow, Heather Bletchly, Caitlin L. Blundell, Susannah R. Blundell, Pritesh Bodalia, Emma Bolam, Elena Boland, Daan Bormans, Nicola Borthwick, Francesca Bowring, Amy Boyd, Penny Bradley, Tanja Brenner, Alice Bridges-Webb, Phillip J. Brown, Claire Brown, Charlie Brown-O’Sullivan, S Bruce, Emily Brunt, William Budd, Yusuf A. Bulbulia, Melanie Bull, Jamie Burbage, Aileen Burn, Karen R. Buttigieg, Nicholas Byard, Ingrid Cabrera Puig, Anna Calvert, Susana Camara, Michelangelo Cao, Federica Cappuccini, R Cardona, João C. R. Cardoso, Melanie Carr, Miles W. Carroll, Andrew Carson‐Stevens, Yasmin de M. Carvalho, Helen R. Casey, Paul Cashen, Thais Regina Y. Castro, Lucía Carratalá-Castro, Katrina Cathie, Ana Cavey, José Cerbino-Neto, Luiz Fernando F. Cezar, Jim Chadwick, Chanice Chanice, David Chapman, Sue Charlton, Katerina S. Cheliotis, Irina Chelysheva, Oliver Chester, Emily Chiplin, Sunder Chita, Jee-Sun Cho, Liliana Cifuentes, Elizabeth Clark, Matthew Clark, Rachel Colin-Jones, Sarah L.K. Collins, Hayley Colton, Christopher P. Conlon, Sean Connarty, Naomi S. Coombes, Cushla Cooper, Rachel Cooper, Lynne Cornelissen, Tumena Corrah, Catherine A. Cosgrove, Fernanda Barroso Costa, Tony Cox, Wendy E.M. Crocker, Sarah Crosbie, Dan Cullen, Debora R.M.F. Cunha, Christina J. Cunningham, Fiona C. Cuthbertson, Daniel Marinho da Costa, Suzete Nascimento Farias da Guarda, Larissa P. da Silva, Antonio Carlos da Silva Moraes, Brad E. Damratoski, Zsofia Danos, Maria T.D.C. Dantas, Mehreen S. Datoo, Chandrabali Datta, Malika Davids, Sarah L. Davies, Kelly Davies, H. Dele Davies, Sophie Davies, J Davies, Elizabeth J. Davis, John D. Davis, José Antônio Mainardi de Carvalho, Jeanne De Jager, Sergio de Jesus, Lis Moreno De Oliveira Kalid, David J. Dearlove, Tesfaye Demissie, Amisha Desai, Stefania Di Marco, Claudio Di Maso, Tanya Dinesh, Claire Docksey, Tao Dong, Francesca R. Donnellan, Tannyth Gomes dos Santos, Thainá G. dos Santos, Erika Pachecho Dos Santos, Naomi Douglas, Charlotte Downing, Jonathan Drake, Rachael Drake-Brockman, Ruth Drury, Joan Du Plessis, Susanna Dunachie, Andrew Duncan, Nicholas Easom, Mandy Edwards, Nick J. Edwards, Frances L. Edwards, Omar M. El Muhanna, Sean C. Elias, Branwen Ellison-Handley, Michael J. Elmore, Marcus Rex English, Alisgair Esmail, Yakub Moosa Essack, Mutjaba Farooq, Sofiya Fedosyuk, Sally Felle, Susie Ferguson, Carla Ferreira Da Silva, Samantha Field, Richard Fisher, James L. K. Fletcher, Hazel Fofie, Henry Fok, Karen Ford, Ross Fothergill, Jamie Fowler, Pedro Henrique Almeida Fraiman,
The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks. The planned roll-out in the UK will involve vaccinating people in high-risk categories with their first dose immediately, and delivering the second dose 12 weeks later. Here, we provide both a further prespecified pooled analysis of trials of ChAdOx1 nCoV-19 and exploratory ...
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