Henri Chahinian, Sofiane Bezzine, Francine Ferrato, Margarita G. Ivanova, Bárbara Angélica Gómez Pérez, Mark E. Lowe, Frédéric Carrière,
The structural similarities between the C-terminal domain of human pancreatic lipase (C-HPL) and C2 domains suggested a similar function, the interaction with lipids. The catalytic N-terminal domain (N-HPL) and C-HPL were produced as individual proteins, and their partitioning between the water phase and the triglyceride−water interface was assessed using trioctanoin emulsions (TC8). N-HPL did not bind efficiently to TC8 and was inactive. C-HPL did bind to TC8 and to a phospholipid monolayer with a ...
Tópico(s): Pancreatic function and diabetes
2002 - American Chemical Society | Biochemistry
Ekaterina L. Ivanova, Barbara Costa, Tanja Eisemann, Sabrina Lohr, Pavle Boskovic, Viktoria Eichwald, Jasmin Meckler, Manfred Jugold, Véronique Orian‐Rousseau, Heike Peterziel, Peter Angel,
Glioblastoma multiforme (GBM) is one of the most common and malignant brain tumors in adulthood with a median survival of only 15 months. This poor prognosis is related to GBM’s ability to extensively infiltrate the surrounding brain parenchyma resulting in diffuse spread of neoplastic cells in the brain, responsible for high rate of recurrence. CD44 (Cluster of Differentiation 44) is a transmembrane protein, overexpressed in multiple cancer types, including gliomas, and implicated in cell motility, ...
Tópico(s): Barrier Structure and Function Studies
2022 - Frontiers Media | Frontiers in Oncology
Yun Teng, Lacey M. Litchfield, Margarita M. Ivanova, Russell A. Prough, Barbara J. Clark, Carolyn M. Klinge,
Although oncomiR miR-21 is highly expressed in liver and overexpressed in hepatocellular carcinoma (HCC), its regulation is uncharacterized. We examined the effect of physiologically relevant nanomolar concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) on miR-21 expression in HepG2 human hepatoma cells. 10 nM DHEA and DHEA-S increase pri-miR-21 transcription in HepG2 cells. Dietary DHEA increased miR-21 in vivo in mouse liver. siRNA and inhibitor studies suggest that DHEA-S requires ...
Tópico(s): RNA Research and Splicing
2014 - Elsevier BV | Molecular and Cellular Endocrinology
Yun Teng, Brandie N. Radde, Lacey M. Litchfield, Margarita M. Ivanova, Russell A. Prough, Barbara J. Clark, Mark A. Doll, David W. Hein, Carolyn M. Klinge,
Little is known about the regulation of the oncomiR miR-21 in liver. Dehydroepiandrosterone (DHEA) regulates gene expression as a ligand for a G-protein-coupled receptor and as a precursor for steroids that activate nuclear receptor signaling. We report that 10 nm DHEA increases primary miR-21 (pri-miR-21) transcription and mature miR-21 expression in HepG2 cells in a biphasic manner with an initial peak at 1 h followed by a second, sustained response from 3–12 h. DHEA also increased miR-21 in primary ...
Tópico(s): Hormonal Regulation and Hypertension
2015 - Elsevier BV | Journal of Biological Chemistry
Gian Maria Bonora, Eugenia M. Ivanova, В. Ф. Зарытова, Barbara Burcovich, Francesco M. Veronese,
The use of synthetic oligonucleotides as possible drugs for human therapy is usually hampered by their low in vivo stability and capacity to achieve high concentrations at their cellular targets. To overcome this, it has been suggested that they be modified chemically. Among the various options, conjugation with short- and long-chain polyethylene glycols (PEGs) has several advantages: PEG is nontoxic and very soluble, reduces immunogenic reactions, and increases the stability of the conjugated molecules. ...
Tópico(s): RNA Interference and Gene Delivery
1997 - American Chemical Society | Bioconjugate Chemistry
R. S. Ivanova, Rosina Staneva, Steffen Geppert, Barbara Heck, Bernd St�hn, Wolfram Gronski, B. Walter,
Tópico(s): Advanced Materials and Mechanics
2004 - Springer Science+Business Media | Colloid & Polymer Science
Reem A. Mustafa, Wojtek Wiercioch, Maicon Falavigna, Yuan Zhang, Liudmila Ivanova, Ingrid Arévalo-Rodríguez, Adrienne Cheung, Barbara Prediger, Matthew Ventresca, Jan Brożek, Nancy Santesso, Patrick M. Bossuyt, Amit X. Garg, N Lloyd, Monika Lelgemann, Diedrich Bühler, Holger J. Schünemann,
The objective of this study was to identify and describe critical appraisal tools designed for assessing the quality of evidence (QoE) and/or strength of recommendations (SoRs) related to health care-related tests and diagnostic strategies (HCTDSs).We conducted a systematic review to identify tools applied in guidelines, methodological articles, and systematic reviews to assess HCTDS.We screened 5,534 titles and abstracts, 1,004 full-text articles, and abstracted data from 330 references. We identified ...
Tópico(s): Clinical Reasoning and Diagnostic Skills
2017 - Elsevier BV | Journal of Clinical Epidemiology
Timothy Voorhees, Nilanjan Ghosh, Natalie S. Grover, Jared Block, Catherine Cheng, Kaitlin Morrison, Anastasia Ivanova, Gianpietro Dotti, Jonathan S. Serody, Barbara Savoldo, Anne Beaven,
Key Points CD30 CAR T-cell therapy promoted a prolonged remission in a patient with multiply relapsed EATL.
Tópico(s): Cutaneous lymphoproliferative disorders research
2020 - Elsevier BV | Blood Advances
Sławomir Wilczyński, Robert Koprowski, Anna Stolecka‐Warzecha, Piotr Duda, Anna Deda, Diana Ivanova, Yoana Kiselova‐Kaneva, Barbara Błońska‐Fajfrowska,
The practice of drug counterfeiting is an important challenge due to the extremely rapid growth rate of this disturbing trend and its immense potential harmfulness. According to WHO even 10% of counterfeit medicines can be exact copies of genuine medicines: they have exactly the same quantitative and qualitative composition in terms of both API and excipients. Thus, the identification of such drugs using chemical analysis methods can be very difficult or even impossible. The aim of this study was ...
Tópico(s): Identification and Quantification in Food
2018 - Elsevier BV | Talanta
Reem A. Mustafa, Wojtek Wiercioch, Ingrid Arévalo-Rodríguez, Adrienne Cheung, Barbara Prediger, Liudmila Ivanova, Matthew Ventresca, Jan Brożek, Nancy Santesso, Patrick M. Bossuyt, Amit X. Garg, N Lloyd, Monika Lelgemann, Diedrich Bühler, Holger J. Schünemann,
Objectives The objective of the study was to describe and compare current practices in developing guidelines about the use of healthcare-related tests and diagnostic strategies (HCTDS). Study Design and Setting We sampled 37 public health and clinical practice guidelines about HCTDS from various sources without language restrictions. Results Detailed descriptions of the systems used to assess the quality of evidence and develop recommendations were challenging to find within guidelines. We observed ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2017 - Elsevier BV | Journal of Clinical Epidemiology
Paweł Olczyk, Katarzyna Komosińska‐Vassev, Ryszard Krzyminiewski, Janusz Kasperczyk, Paweł Ramos, Bernadeta Dobosz, Olgierd Batoryna, Jerzy Stojko, Mateusz Stojko, Diana Ivanova, Krystyna Olczyk, Barbara Pilawa,
The evolution of the paramagnetic center system in blood during the healing of skin burn wounds dressed with a biodegradable apitherapeutic nanofiber dressing was examined. The aim of this study was to determine the changes in paramagnetic centers in blood during the influence of apitherapeutic nanofiber dressings on the healing process. The blood samples were tested before burn infliction (day 0) and, respectively, on the 10 th and 21 st days of the experiment. Paramagnetic centers in the blood ...
Tópico(s): Bee Products Chemical Analysis
2020 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Yury Shamis, A. Taube, Yury Shramkov, Natasa Mitik‐Dineva, Barbara Vu, Elena P. Ivanova,
The present study developed and verified a 'cold' microwave (MW) treatment that could lead to the inactivation of two common pathogenic species of bacteria, Escherichia coli and Staphylococcus aureus, in raw meats. A number of experimental conditions were designed and tested to maximise MW exposure without overheating the samples. The non-thermal effect was maximised by multiple exposure to attain efficient MW threshold intensities. It was shown that at sub-lethal temperatures repeated exposure using ...
Tópico(s): Listeria monocytogenes in Food Safety
2008 - De Gruyter | International Journal of Food Engineering
Nikita A. Olekhno, Egor I. Kretov, Andrei A. Stepanenko, Polina A. Ivanova, Vitaly Yaroshenko, Ekaterina Puhtina, Dmitry Filonov, Barbara Cappello, Ladislau Matekovits, Maxim A. Gorlach,
Topological physics opens up a plethora of exciting phenomena allowing to engineer disorder-robust unidirectional flows of light. Recent advances in topological protection of electromagnetic waves suggest that even richer functionalities can be achieved by realizing topological states of quantum light. This area, however, remains largely uncharted due to the number of experimental challenges. Here, we take an alternative route and design a classical structure based on topolectrical circuits which ...
Tópico(s): Random lasers and scattering media
2020 - Nature Portfolio | Nature Communications
Karyna Calvopiña, Omar Malagón, Francesca Capetti, Barbara Sgorbini, Verónica Ivanova Verdugo Tinitana, Gianluca Gilardoni,
As part of a project devoted to the phytochemical study of Ecuadorian biodiversity, new essential oils are systematically distilled and analysed. In the present work, Jungia rugosa Less (Asteraceae) has been selected and some wild specimens collected to investigate the volatile fraction. The essential oil, obtained from fresh leaves, was analysed for the first time in the present study. The chemical composition was determined by gas chromatography, coupled to mass spectrometry (GC-MS) for qualitative ...
Tópico(s): Chemical synthesis and alkaloids
2021 - Multidisciplinary Digital Publishing Institute | Plants
Joel Greshock, Bin Feng, Cristina Nogueira, Elena Ivanova, Ilana Perna, Katherine L. Nathanson, Alexei Protopopov, Barbara Weber, Lynda Chin,
Abstract The accurate mapping of recurring DNA copy number aberrations (CNAs), a hallmark feature of the cancer genome, has facilitated the discovery of tumor suppressor genes and oncogenes. Microarray-based assays designed to detect these chromosomal copy number alterations on a genome-wide and high-resolution scale have emerged as a cornerstone technology in the genomic era. The diversity of commercially available platforms prompted a systematic comparison of five copy number profiling assays for ...
Tópico(s): Chromosomal and Genetic Variations
2007 - American Association for Cancer Research | Cancer Research
Produção Nacional
Revisado por pares
Barbara A. Piperata, Sofia A. Ivanova, Pedro Da‐Gloria, Gonçalo Veiga, Analise Polsky, Jennifer E. Spence, Rui Sérgio Sereni Murrieta,
Abstract Objectives: The goal of this study was to understand the relationship between economic change (wage labor, retirement, and the Bolsa Família program) and dietary patterns in the rural Amazon and to determine the extent to which these changes followed the pattern of the nutrition transition. Methods: The study was longitudinal. The weighed‐inventory method and economic interviews were used to collect data on dietary intake and household economics in a sample of 30 and 52 women in 2002 and ...
Tópico(s): Breastfeeding Practices and Influences
2011 - Wiley | American Journal of Human Biology
Darinka Christova, Sijka Ivanova, Barbara Trzebicka, Wojciech Wałach, Rumiana Velichkova, Andrzej Dworak,
Abstract In order to obtain temperature-responsive hydrogel networks, poly- (glycidol-block-ethylene oxide-block-glycidol) copolymers were chemically crosslinked by using glutaraldehyde and tetraethoxysilane in a sol-gel reaction. The crystallinity of copolymer networks prepared has been estimated by differential scanning calorimetry. Thermo-responsive properties were evaluated by measuring the equilibrium swelling degree for a series of copolymer hydrogels as a function of temperature.
Tópico(s): Polymer Nanocomposites and Properties
2003 - De Gruyter | e-Polymers
Hans Herfarth, Susan Jackson, Barbara Schliebe, Christopher Martin, Anastasia Ivanova, Kristen Anton, Robert S. Sandler, Millie D. Long, Kim L. Isaacs, Mark T. Osterman, Bruce E. Sands, Peter Higgins, James D. Lewis,
Investigator-initiated randomized clinical trials are the backbone of academic clinical research. Investigator-initiated trials (IITs) complement the large clinical studies sponsored by industry and address questions, which are usually not the main focus of a commercially directed research but have the purpose to confirm, improve, or refute clinically important questions with regard to diagnostic and therapeutic approaches in patient care. The aim of this review is to illustrate the necessary steps ...
Tópico(s): Inflammatory Bowel Disease
2016 - Oxford University Press | Inflammatory Bowel Diseases
Thomas Walle, Erkin Erdal, Leon Mühlsteffen, Hans Martin Singh, Editha Gnutzmann, Barbara Grün, Helene Hofmann, Alexandra Ivanova, Bruno Köhler, Felix Korell, Athanasios Mavratzas, Andreas Möck, Constantin Pixberg, David Schult, H Starke, Niels Steinebrunner, Lena Woydack, Andreas Schneeweiß, Mareike Dietrich, Dirk Jäger, Johannes Krisam, Jakob Nikolas Kather, Eva C. Winkler,
Mobile phone video call applications generally did not undergo testing in randomised controlled clinical trials prior to their implementation in patient care regarding the rate of successful patient visits and impact on the physician-patient relationship.The National Center for Tumour Diseases (NCT) MOBILE trial was a monocentric open-label randomised controlled clinical trial of patients with solid tumours undergoing systemic cancer therapy with need of a follow-up visit with their consulting physician ...
Tópico(s): Family and Patient Care in Intensive Care Units
2020 - Elsevier BV | ESMO Open
Courtney A. Lovejoy, Wen‐Di Li, Steven Reisenweber, Supawat Thongthip, Joanne Bruno, Titia de Lange, Saurav De, John H.J. Petrini, Patricia Sung, Maria Jasin, Joseph Rosenbluh, Yaara Zwang, Barbara A. Weir, Charlie Hatton, Elena Ivanova, Laura E. MacConaill, Megan Hanna, William C. Hahn, Neal F. Lue, Roger R. Reddel, Yuchen Jiao, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos, Alan K. Meeker,
The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent pathway for telomere maintenance that is active in a significant subset of human cancers and in vitro immortalized cell lines. ALT is thought to involve templated extension of telomeres through homologous recombination, but the genetic or epigenetic changes that unleash ALT are not known. Recently, mutations in the ATRX/DAXX chromatin remodeling complex and histone H3.3 were found to correlate with features of ALT ...
Tópico(s): Genomics and Chromatin Dynamics
2012 - Public Library of Science | PLoS Genetics
Jordanka Ivanova, Gergana Nikolova, Barbara Gambin,
Abstract The interface behaviour between two layers of 2D elastic structure under dynamic time‐harmonic load is studied. The “shear lag model” is adopted and applied to the dynamic response of bi‐material structure, assuming the elastic‐brittle behaviour of the interface. The Laplace transforms together with half‐analytical calculations are used to obtain the shear stress and elastic debond lengths along the interface at sinusoidal load. Parametric analysis of the obtained results is illustrated ...
Tópico(s): Mechanical Behavior of Composites
2010 - Wiley | ZAMM ‐ Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik
Brian Johnston, Iza Radecka, Emo Chiellini, David Barsi, Vassilka Ivanova Ilieva, Wanda Sikorska, Marta Musioł, Magdalena Zięba, Paweł Chaber, Adam A. Marek, Barbara Mendrek, Anabel Itohowo Ekere, Grażyna Adamus, Marek Kowalczuk,
This study investigated the molecular structure of the polyhydroxyalkanoate (PHA) produced via a microbiological shake flask experiment utilizing oxidized polypropylene (PP) waste as an additional carbon source. The bacterial strain Cupriavidus necator H16 was selected as it is non-pathogenic, genetically stable, robust, and one of the best known producers of PHA. Making use of PHA oligomers, formed by controlled moderate-temperature degradation induced by carboxylate moieties, by examination of both ...
Tópico(s): Recycling and Waste Management Techniques
2019 - Multidisciplinary Digital Publishing Institute | Polymers
Timothy Voorhees, Beibo Zhao, Jorge D. Oldan, George Hucks, Amir H. Khandani, Christopher Dittus, Jennifer K. Smith, J. Kaitlin Morrison, Catherine Cheng, Anastasia Ivanova, Steven Park, Thomas C. Shea, Anne Beaven, Gianpietro Dotti, Jonathan S. Serody, Barbara Savoldo, Natalie S. Grover,
Our group has recently demonstrated that chimeric antigen receptor T-cell therapy targeting the CD30 antigen (CD30.CAR-T) is highly effective in patients with relapsed and refractory (r/r) classical Hodgkin lymphoma (cHL). Despite high rates of clinical response, relapses and progression were observed in a subset of patients. The objective of this study was to characterize clinical and correlative factors associated with progression-free survival (PFS) after CD30.CAR-T cell therapy. We evaluated correlatives ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2021 - Elsevier BV | Blood Advances
Luke Woodford, Giovanni Bianco, Yoana Ivanova, Maeve Dale, Kathryn R. Elmer, Fiona K. Rae, Stephen D. Larcombe, Barbara Helm, Heather M. Ferguson, Francesco Baldini,
Artificial infection of mosquitoes with the endosymbiont bacteria Wolbachia can interfere with malaria parasite development. Therefore, the release of Wolbachia-infected mosquitoes has been proposed as a malaria control strategy. However, Wolbachia effects on vector competence are only partly understood, as indicated by inconsistent effects on malaria infection reported under laboratory conditions. Studies of naturally-occurring Wolbachia infections in wild vector populations could be useful to ...
Tópico(s): Mosquito-borne diseases and control
2018 - Nature Portfolio | Scientific Reports
Brian Johnston, Iza Radecka, David Hill, Emo Chiellini, Vassilka Ivanova Ilieva, Wanda Sikorska, Marta Musioł, Magdalena Zięba, Adam A. Marek, Daniel J. Keddie, Barbara Mendrek, Surila Darbar, Grażyna Adamus, Marek Kowalczuk,
Excessive levels of plastic waste in our oceans and landfills indicate that there is an abundance of potential carbon sources with huge economic value being neglected. These waste plastics, through biological fermentation, could offer alternatives to traditional petrol-based plastics. Polyhydroxyalkanoates (PHAs) are a group of plastics produced by some strains of bacteria that could be part of a new generation of polyester materials that are biodegradable, biocompatible, and, most importantly, non- ...
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2018 - Multidisciplinary Digital Publishing Institute | Polymers
A. V. Lee, P. Zhang, Margarita M. Ivanova, Sharon G. Bonnette, Steffi Oesterreich, Jeffrey M. Rosen, Sandra L. Grimm, Russel C. Hovey, Barbara K. Vonderhaar, C. Ronald Kahn, Dolores Torres, J. George, S K Mohsin, D. Craig Allred, Darryl L. Hadsell,
Insulin receptor substrates (IRS) are central integrators of hormone, cytokine, and growth factor signaling. IRS proteins can be phosphorylated by a number of signaling pathways critical to normal mammary gland development. Studies in transgenic mice that overexpress IGF-I in the mammary gland suggested that IRS expression is important in the regulation of normal postlactational mammary involution. The goal of these studies was to examine IRS expression in the mouse mammary gland and determine the ...
Tópico(s): Cancer Cells and Metastasis
2003 - Oxford University Press | Endocrinology
Barbara Costa, Michael Fletcher, Pavle Boskovic, Ekaterina Ivanova, Tanja Eisemann, Sabrina Lohr, Lukas Bunse, Martin Löwer, Stefanie Burchard, Andrey Korshunov, Nadia Coltella, Melania Cusimano, Luigi Naldini, Hai‐Kun Liu, Michael Platten, Bernhard Radlwimmer, Peter Angel, Heike Peterziel,
Glioblastomas (GBM) are the most aggressive tumors affecting the central nervous system in adults, causing death within, on average, 15 months after diagnosis. Immunocompetent in-vivo models that closely mirror human GBM are urgently needed for deciphering glioma biology and for the development of effective treatment options. The murine GBM cell lines currently available for engraftment in immunocompetent mice are not only exiguous but also inadequate in representing prominent characteristics of ...
Tópico(s): Immune cells in cancer
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Antônio Pedro Camargo, Lee Call, Simon Roux, Stephen Nayfach, Marcel Huntemann, Krishna Palaniappan, Anna Ratner, Ken Chu, Supratim Mukherjee, T. B. K. Reddy, I-Min A. Chen, Natalia Ivanova, Emiley A. Eloe‐Fadrosh, Tanja Woyke, David A. Baltrus, Salvador Castañeda-Barba, Fernando de la Cruz, Barbara E. Funnell, James P. J. Hall, Aindrila Mukhopadhyay, Eduardo P. C. Rocha, Thibault Stalder, Eva M. Top, Nikos C. Kyrpides,
Abstract Plasmids are mobile genetic elements found in many clades of Archaea and Bacteria. They drive horizontal gene transfer, impacting ecological and evolutionary processes within microbial communities, and hold substantial importance in human health and biotechnology. To support plasmid research and provide scientists with data of an unprecedented diversity of plasmid sequences, we introduce the IMG/PR database, a new resource encompassing 699 973 plasmid sequences derived from genomes, metagenomes ...
Tópico(s): Antibiotic Resistance in Bacteria
2023 - Oxford University Press | Nucleic Acids Research
Barbara Vu, Miao Chen, Russell J. Crawford, Elena P. Ivanova,
Extracellular polymeric substances (EPS) produced by microorganisms are a complex mixture of biopolymers primarily consisting of polysaccharides, as well as proteins, nucleic acids, lipids and humic substances. EPS make up the intercellular space of microbial aggregates and form the structure and architecture of the biofilm matrix. The key functions of EPS comprise the mediation of the initial attachment of cells to different substrata and protection against environmental stress and dehydration. ...
Tópico(s): Wastewater Treatment and Nitrogen Removal
2009 - Multidisciplinary Digital Publishing Institute | Molecules
Barbara Gambin, Jordanka Ivanova, V. Valeva, Gergana Nikolova,
Tópico(s): Composite Structure Analysis and Optimization
2011 - Springer Science+Business Media | Acta Mechanica Sinica