... in Coaching: Essay for the First Steps Alexandra Barosa-Pereira PCC, Alexandra Barosa-Pereira PCCSearch for more papers by this author Alexandra Barosa-Pereira PCC, Alexandra Barosa-Pereira PCCSearch for more papers by this author ...
Tópico(s): Gender Diversity and Inequality
2014 - Wiley | Journal of Psychological Issues in Organizational Culture
Bruno Hay Mele, Maria Monticelli, Serena Leone, Deborah Bastoni, Bernardo Barosa, Martina Cascone, Flavia Migliaccio, Francesco Montemagno, Annarita Ricciardelli, Luca Tonietti, A. Rotundi, Angelina Cordone, Donato Giovannelli,
Life sustains itself using energy generated by thermodynamic disequilibria, commonly existing as redox disequilibria. Metals are significant players in controlling redox reactions, as they are essential components of the engine that life uses to tap into the thermodynamic disequilibria necessary for metabolism. The number of proteins that evolved to catalyze redox reactions is extraordinary, as is the diversification level of metal cofactors and catalytic domain structures involved. Notwithstanding ...
Tópico(s): Origins and Evolution of Life
2023 - Portland Press | Essays in Biochemistry
Theresia Sarabhai, S. Kahl, Julia Szendroedi, Daniel F. Markgraf, Oana‐Patricia Zaharia, Cristina Barosa, Christian Herder, Frithjof Wickrath, Pavel Bobrov, Jonghee Hwang, John G. Jones, Michael Roden,
BACKGROUNDWhile saturated fat intake leads to insulin resistance and nonalcoholic fatty liver, Mediterranean-like diets enriched in monounsaturated fatty acids (MUFA) may have beneficial effects. This study examined effects of MUFA on tissue-specific insulin sensitivity and energy metabolism.METHODSA randomized placebo-controlled cross-over study enrolled 16 glucose-tolerant volunteers to receive either oil (OIL, ~1.18 g/kg), rich in MUFA, or vehicle (VCL, water) on 2 occasions. Insulin sensitivity ...
Tópico(s): Diet, Metabolism, and Disease
2020 - American Society for Clinical Investigation | JCI Insight
S Saraiva, João Cortez-Pinto, Rita Barosa, Joana Castela, Joana Moleiro, Isadora Rosa, João Pereira da Siva, António Dias Pereira,
Background: Fatigue is a common symptom reported in inflammatory bowel disease (IBD) patients. It can be severe and modify the self-perception of disease.Objective: To evaluate the contribution of clinical and demographic factors to the level of fatigue in IBD patients.Methods: Patients consecutively observed in an outpatient IBD clinic during a 9-month period were studied. Demographic and clinical data were collected. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy- ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2019 - Taylor & Francis | Scandinavian Journal of Gastroenterology
David B. Savage, Laura Watson, Katie Carr, Claire Adams, Søren Brage, Krishna Chatterjee, Leanne Hodson, Chris Boesch, Graham J. Kemp, Alison Sleigh,
... Kupriyanova Y. Nowotny B. Nowotny P. Herder C. Barosa C. et al.Acute dietary fat intake initiates ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2019 - Elsevier BV | Journal of Lipid Research
Rita Barosa, Lídia Roque Ramos, Marta Patita, Gonçalo Nunes, Jorge Fonseca,
Acute-on-chronic liver failure (ACLF) is a frequent syndrome associated with high mortality. The aims of the present study are: a) comparing the Chronic Liver Failure Consortium (CLIF-C) ACLF Model for End-Stage Liver Disease (MELD), MELD Sodium (MELD-Na) and Child-Turcotte-Pugh (CTP) scores for prediction of short/medium term mortality; b) identifying ACLF prevalence in patients admitted to the ward; and c) comparing mortality between non-ACLF/ACLF.Retrospective cohort study of 177 patients admitted ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2017 - Arán Ediciones | Revista Española de Enfermedades Digestivas
Gonçalo Nunes, Carla Adriana Santos, Rita Barosa, Cristina Fonseca, Ana Teresa Barata, Jorge Fonseca,
Protein-calorie malnutrition is common in chronic liver disease (CLD) but adequate clinical tools for nutritional assessment are not defined.In CLD patients, it was aimed: 1. Characterize protein-calorie malnutrition; 2. Compare several clinical, anthropometric and functional tools; 3. Study the association malnutrition/CLD severity and malnutrition/outcome.Observational, prospective study. Consecutive CLD ambulatory/hospitalised patients were recruited from 01-03-2012 to 31-08-2012, studied according ...
Tópico(s): Clinical Nutrition and Gastroenterology
2017 - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) | Arquivos de Gastroenterologia
Fernando Magro, Cláudia Camila Dias, Rosa Coelho, Paula Moura Santos, Samuel Fernandes, Cidalina Caetano, Ângela Rodrigues, Francisco Portela, Ana Oliveira, Paula Ministro, Eugénia Cancela, Ana Vieira, Rita Barosa, José Cotter, Pedro Boal Carvalho, Isabelle Cremers, Daniel Trabulo, Paulo Caldeira, Artur Gião Antunes, Isadora Rosa, Joana Moleiro, Paula Peixe, Rita Herculano, Raquel Gonçalves, Bruno Gonçalves, Helena Tavares de Sousa, Luís Contente, Henrique Morna, Susana Lopes,
The definition of early therapeutic strategies to control Crohn's disease aggressiveness and prevent recurrence is key to improve clinical practice. This study explores the impact of early surgery and immunosuppression onset in the occurrence of disabling outcomes.This was a multicentric and retrospective study with 754 patients with Crohn's disease, who were stratified according to the need for an early surgery (group S) or not (group I) and further divided according to the time elapsed from the ...
Tópico(s): Autoimmune and Inflammatory Disorders
2017 - Oxford University Press | Inflammatory Bowel Diseases
Rita Barosa, Lídia Roque Ramos, Carla Adriana Santos, Marta Pereira, Jorge Fonseca,
Body Mass Index (BMI) is a simple and widespread method to assess undernutrition. However its use may be limited in bedridden patients.1) compare BMI, Mid Upper Arm Circumference (MUAC) and Powell-Tuck and Hennessy's regression equation for BMI (BMIPTH) in gastrostomy fed patients, 2) validate its correlation for sequential use and 3) select the best cut-off of MUAC and BMIPTH to predict risk of undernutrition.Prospective study including adult patients who underwent endoscopic gastrostomy (PEG). BMI, ...
Tópico(s): Child Nutrition and Feeding Issues
2017 - Elsevier BV | Clinical Nutrition
Elisa Álvarez Hernández, S. Kahl, Anett Seelig, Paul Begovatz, Martin Irmler, Yuliya Kupriyanova, Bettina Nowotny, P. Nowotny, Christian Herder, Cristina Barosa, Filipa Carvalho, Jan Rozman, Susanne Neschen, John G. Jones, Johannes Beckers, Martin Hrabĕ de Angelis, Michael Roden,
BACKGROUND. Dietary intake of saturated fat is a likely contributor to nonalcoholic fatty liver disease (NAFLD) and insulin resistance, but the mechanisms that initiate these abnormalities in humans remain unclear. We examined the effects of a single oral saturated fat load on insulin sensitivity, hepatic glucose metabolism, and lipid metabolism in humans. Similarly, initiating mechanisms were examined after an equivalent challenge in mice.
Tópico(s): Diet and metabolism studies
2017 - American Society for Clinical Investigation | Journal of Clinical Investigation
Ron T. Varghese, Iván Viegas, Cristina Barosa, Cátia Marques, Meera Shah, Robert A. Rizza, John G. Jones, Adrian Vella,
A common genetic variation in TCF7L2 is associated with type 2 diabetes. However, the mechanism by which this occurs remains elusive. In addition to affecting insulin secretion, genetic variation at the TCF7L2 locus may alter insulin action or directly modify hepatic glucose metabolism. We sought to determine whether the diabetes-associated variant in this locus (the T allele of rs7903146) increases fasting endogenous glucose production (EGP), and impairs insulin-induced suppression of EGP and insulin- ...
Tópico(s): Amino Acid Enzymes and Metabolism
2016 - American Diabetes Association | Diabetes
Rita Barosa, João Pinto, Ana Teresa Caldeira, Eduardo Pereira,
Tópico(s): Congenital Anomalies and Fetal Surgery
2016 - Springer Science+Business Media | Journal of Medical Ultrasonics
Cláudia Camila Dias, Pedro Pereira Rodrigues, Rosa Coelho, Paula Moura Santos, Samuel Fernandes, Paula Lago, Cidalina Caetano, Ângela Rodrigues, Francisco Portela, Ana Oliveira, Paula Ministro, Eugénia Cancela, Ana Vieira, Rita Barosa, José Cotter, Pedro Boal Carvalho, Isabelle Cremers, Daniel Trabulo, Paulo Caldeira, Artur Gião Antunes, Isadora Rosa, Joana Moleiro, Paula Peixe, Rita Herculano, Raquel Gonçalves, Bruno Gonçalves, Helena Tavares de Sousa, Luís Contente, Henrique Morna, Susana Lopes, Fernando Magro,
The establishment of prognostic models for Crohn's disease [CD] is highly desirable, as they have the potential to guide physicians in the decision-making process concerning therapeutic choices, thus improving patients' health and quality of life. Our aim was to derive models for disabling CD and reoperation based solely on clinical/demographic data. A multicentric and retrospectively enrolled cohort of CD patients, subject to early surgery or immunosuppression, was analysed in order to build Bayesian ...
Tópico(s): Colorectal Cancer Screening and Detection
2016 - Oxford University Press | Journal of Crohn s and Colitis
Ana Marlúcia Oliveira Assis, Joana C. Branco, Rita Barosa, José A. Rodrigues, Lidia Martínez Ramos, Alexandra Martins, Constantine Karvellas, Filipe S. Cardoso,
Spontaneous bacterial peritonitis (SBP) is a prevalent and high mortality complication of cirrhosis. We aimed to describe these patients' clinical and microbiological characteristics and evaluate their impact on outcomes.This was a retrospective cohort study including 139 consecutive patients with positive culture SBP from three Portuguese centers diagnosed between 2009 and 2014. Multivariate logistic regression was used to study associations with 30-day mortality.The mean age of the patients was ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2016 - Lippincott Williams & Wilkins | European Journal of Gastroenterology & Hepatology
J. Barosa, João Carlos Ribeiro, LP Afonso, Joana Fernandes, Eurico Monteiro,
The purpose of this study was to analyze the outcome of patients suffering from head and neck sarcomas and to identify indicators of outcome.The medical records of 43 patients treated between 2000 and 2010 were analyzed. All patients were suffering from primary head and neck sarcoma. The final study sample included 29 patients.Mean survival was 56 months. Overall 2- and 5-year survivorship was 69% and 31% respectively. Parameters positively influencing survival were: male gender; non-smoker; alcohol ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2014 - Elsevier BV | European Annals of Otorhinolaryngology Head and Neck Diseases
Rita Basu, Cristina Barosa, John G. Jones, Simmi Dube, Rickey E. Carter, Ananda Basu, Robert A. Rizza,
People with prediabetes are at high risk of developing diabetes.The objective of this study was to determine the pathogenesis of fasting and postprandial hyperglycemia in prediabetes.Glucose production, gluconeogenesis, glycogenolysis, and glucose disappearance were measured before and during a hyperinsulinemic clamp using [6,6-(2)H2]glucose and the deuterated water method corrected for transaldolase exchange.The study was conducted at the Mayo Clinic Clinical Research Unit.Subjects with impaired ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2013 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Teresa C. Delgado, Cristina Barosa, Patrícia M. Nunes, Sebastián Cerdán, Carlos F. G. C. Geraldes, John G. Jones,
Sources of plasma glucose excursions (PGE) following a glucose tolerance test enriched with [U-13C]glucose and deuterated water were directly resolved by 13C and 2H Nuclear Magnetic Resonance spectroscopy analysis of plasma glucose and water enrichments in rat. Plasma water 2H-enrichment attained isotopic steady-state within 2–4 minutes following the load. The fraction of PGE derived from endogenous sources was determined from the ratio of plasma glucose position 2 and plasma water 2H-enrichments. ...
Tópico(s): Diet, Metabolism, and Disease
2012 - Public Library of Science | PLoS ONE
Cristina Barosa, Claudia Silva, Ana Fagulha, Luísa Barros, M. Madalena Caldeira, Manuela Carvalheiro, John G. Jones,
During feeding, dietary galactose is a potential source of hepatic glycogen synthesis; but its contribution has not been measured to date. In the presence of deuterated water ((2)H(2)O), uridine diphosphate (UDP)-glucose derived from galactose is not enriched, whereas the remainder derived from glucose-6-phosphate (G6P) is enriched in position 2 to the same level as body water, assuming complete G6P-fructose-6-phosphate (F6P) exchange. Hence, the difference between UDP-glucose position 2 and body water ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2011 - Elsevier BV | Metabolism
Michaela Kacerovsky, John G. Jones, A. Schmid, Cristina Barosa, Angelika Lettner, Gertrud Kacerovsky-Bielesz, Julia Szendroedi, Marek Chmelík, P. Nowotny, Visvanathan Chandramouli, Michael Wolzt, Michael Roden,
Intravenous insulin infusion partly improves liver glucose fluxes in type 1 diabetes (T1D). This study tests the hypothesis that continuous subcutaneous insulin infusion (CSII) normalizes hepatic glycogen metabolism.T1D with poor glycemic control (T1Dp; HbA(1c): 8.5 ± 0.4%), T1D with improved glycemic control on CSII (T1Di; 7.0 ± 0.3%), and healthy humans (control subjects [CON]; 5.2 ± 0.4%) were studied. Net hepatic glycogen synthesis and glycogenolysis were measured with in vivo (13)C magnetic resonance spectroscopy. ...
Tópico(s): Diet and metabolism studies
2011 - American Diabetes Association | Diabetes
Produção Nacional
Revisado por pares
Elson S. Alvarenga, S. A. Silva, L.C.A. Barosa, Antônio J. Demuner, Adriano Guimarães Parreira, Rosy Iara Maciel de Azambuja Ribeiro, Silvana Marcussi, Jaqueline Maria Siqueira Ferreira, Rodrigo R. Resende, Paulo Afonso Granjeiro, J.A. Silva, Andreimar M. Soares, Sérgio Marangoni, Saulo L. da Silva,
Several sesquiterpene lactone were synthesized and their inhibitive activities on phospholipase A(2) (PLA(2)) from Bothrops jararacussu venom were evaluated. Compounds Lac01 and Lac02 were efficient against PLA(2) edema-inducing, enzymatic and myotoxic activities and it reduces around 85% of myotoxicity and around 70% of edema-inducing activity. Lac05-Lac08 presented lower efficiency in inhibiting the biological activities studied and reduce the myotoxic and edema-inducing activities around only ...
Tópico(s): Bioactive Natural Diterpenoids Research
2010 - Elsevier BV | Toxicon
John G. Jones, Paula Garcia, Cristina Barosa, Teresa C. Delgado, Luísa Diogo,
Hepatic glucose production and relative Krebs cycle fluxes (indexed to a citrate synthase flux of 1.0) were evaluated with [U-13C]glycerol tracer in 5 fed healthy controls and 5 Type 1a glycogen storage disease (GSD1a) patients. Plasma glucose, hepatic glucose-6-phosphate (G6P) and glutamine 13C-isotopomers were analyzed by 13C NMR via blood sampling and chemical biopsy. In healthy subjects, 35±14% of plasma glucose originated from hepatic G6P while GSD1a patients had no detectable G6P contribution. ...
Tópico(s): Amino Acid Enzymes and Metabolism
2009 - Elsevier BV | Metabolic Engineering
Cristina M. Sena, Cristina Barosa, Elsa Nunes, Raquel Seiça, John G. Jones,
Plasma glucose, insulin and glucose tolerance were quantified in diabetic Goto-Kakizaki (GK) rats (342 ± 45 g, n = 5) and compared with weight-matched non-diabetic Wistars (307 ± 30 g, n = 8).Compared to Wistars, GK rats had higher fasting plasma insulin (219 ± 50 versus 44 ± 14 pmol/l, P < 0.002) and glucose (9.2 ± 2.3 versus 5.5 ± 0.5 mmol/l, P < 0.025).GK rats showed impaired glucose tolerance (IPGTT 2 h plasma glucose = 14 ± 1.5 versus 6.4 ± 0.1 mmol/l, P < 0.001).Endogenous glucose production (EGP) from glycogenolysis, phosphoenolpyruvate ( ...
Tópico(s): Diet and metabolism studies
2007 - Elsevier BV | Diabetes & Metabolism
Ana C. Mendes, M. Madalena Caldeira, Cláudia Silva, Shawn C. Burgess, Matthew E. Merritt, Filipe Coreta‐Gomes, Cristina Barosa, Teresa C. Delgado, Fátima Franco, Pedro Monteiro, Luís A. Providência, John G. Jones,
Abstract Menthol glucuronide was isolated from the urine of a healthy 70‐kg female subject following ingestion of 400 mg of peppermint oil and 6 g of 99% [U‐ 13 C]glucose. Glucuronide 13 C‐excess enrichment levels were 4–6% and thus provided high signal‐to‐noise ratios (SNRs) for confident assignment of 13 C‐ 13 C spin‐coupled multiplet components within each 13 C resonance by 13 C NMR. The [U‐ 13 C]glucuronide isotopomer derived via direct pathway conversion of [U‐ 13 C]glucose to [U‐ 13 C]UDP‐glucose ...
Tópico(s): Liver Disease Diagnosis and Treatment
2006 - Wiley | Magnetic Resonance in Medicine
Iola F. Duarte, Brian J. Goodfellow, António S. Barros, John G. Jones, Cristina Barosa, Luísa Diogo, Paula Garcia, Ana M. Gil,
Abstract This paper reports the first application of high‐resolution 1 H NMR spectroscopy to the plasma of five juveniles with glycogen storage disease type 1a (GSD1a), permitting the characterisation of the plasma metabolic profile and the identification of alterations relative to a set of control samples. The relaxation‐weighted spectra allowed changes in low molecular weight compounds to be detected more clearly, whereas diffusion‐edited spectra were used to characterise the plasma lipoprotein ...
Tópico(s): Lysosomal Storage Disorders Research
2006 - Wiley | NMR in Biomedicine
John G. Jones, Ana Fagulha, Cristina Barosa, Margarida Bastos, Luísa Barros, Carla Baptista, M. Madalena Caldeira, Manuela Carvalheiro,
The contributions of hepatic glycogenolysis to fasting glucose production and direct pathway to hepatic glycogen synthesis were quantified in eight type 1 diabetic patients and nine healthy control subjects by ingestion of (2)H(2)O and acetaminophen before breakfast followed by analysis of urinary water and acetaminophen glucuronide. After overnight fasting, enrichment of glucuronide position 5 relative to body water (G5/body water) was significantly higher in type 1 diabetic patients compared with ...
Tópico(s): Metabolism and Genetic Disorders
2006 - American Diabetes Association | Diabetes
John G. Jones, Cristina Barosa, Filipe Coreta‐Gomes, Ana C. Mendes, Teresa C. Delgado, Luísa Diogo, Paula Garcia, Margarida Bastos, Luísa Barros, Ana Fagulha, Carla Baptista, Manuela Carvalheiro, M. Madalena Caldeira,
Quantification of 2H and 13C enrichment distributions in human urinary glucuronide following ingestion of 2H2O and 13C gluconeogenic tracers was achieved by NMR spectroscopy of the 1,2‐O‐isopropylidene‐α‐D‐glucofuranurono‐6,3‐lactone and 5‐O‐acetyl‐1,2‐O‐isopropylidene‐α‐D‐glucofuranurono‐6,3‐lactone derivatives. The derivatization process is simple and can be applied to any glucuronide species. The derivatives are highly soluble in acetonitrile and generate well‐resolved and narrow 2H and 13C NMR ...
Tópico(s): Analytical Chemistry and Chromatography
2006 - Taylor & Francis | Journal of Carbohydrate Chemistry
A. Pedro Ribeiro, M. Madalena Caldeira, Manuela Carvalheiro, Margarida Bastos, Carla Baptista, Ana Fagulha, Luísa Barros, Cristina Barosa, John G. Jones,
Abstract The contribution of gluconeogenesis to fasting glucose production was determined by a simple measurement of urinary menthol glucuronide (MG) 2 H enrichment from 2 H 2 O. Following ingestion of 2 H 2 O (0.5% body water) during an overnight fast and a pharmacological dose (400 mg) of a commercial peppermint oil preparation the next morning, 364 μmol MG was quantitatively recovered from a 2‐h urine collection by ether extraction and a 125 μmol portion was directly analyzed by 2 H NMR. The glucuronide ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2005 - Wiley | Magnetic Resonance in Medicine
M. Helena Estevão, Lina Maria Ferreira Winckler Barosa, Luisa Maria Abreu Freire Diogo Matos, Ângelo Augusto Barroso, Henrique Carmona da Mota,
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1995 - Springer Science+Business Media | European Journal of Pediatrics
Gonçalo Nunes, Hélder Coelho, Marta Patita, Rita Barosa, Pedro Pinto-Marques, Lídia Roque Ramos, María José Brito, Aurora Tomaz, Jorge Fonseca,
Tópico(s): Neuroendocrine Tumor Research Advances
2017 - Springer Science+Business Media | Clinical Journal of Gastroenterology
Ron T. Varghese, Chiara Dalla Man, Anu Sharma, Iván Viegas, Cristina Barosa, Cátia Marques, Meera Shah, John J. Miles, Robert A. Rizza, John G. Jones, Claudio Cobelli, Adrian Vella,
Context: Prediabetes is a heterogeneous disorder classified on the basis of fasting glucose concentrations and 2-hour glucose tolerance. Objective: We sought to determine the relative contributions of insulin secretion and action to the pathogenesis of isolated impaired glucose tolerance (IGT). Design: The study consisted of an oral glucose tolerance test and a euglycemic clamp performed in two cohorts matched for anthropometric characteristics and fasting glucose but discordant for glucose tolerance. ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2016 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism