Gerrit Smit, Bart Smit, Wim Engels,
Flavour development in dairy fermentations, most notably cheeses, results from a series of (bio)chemical processes in which the starter cultures provide the enzymes. Particularly the enzymatic degradation of proteins (caseins) leads to the formation of key-flavour components, which contribute to the sensory perception of dairy products. More specifically, caseins are degraded into peptides and amino acids and the latter are major precursors for volatile aroma compounds. In particular, the conversion ...
Tópico(s): Meat and Animal Product Quality
2005 - Oxford University Press | FEMS Microbiology Reviews
G SMIT, Bart. A. Smit, Wim Engels,
Flavour development in dairy fermentations, most notably cheeses, results from a series of (bio)chemical processes in which the starter cultures provide the enzymes. Particularly the enzymatic degradation of proteins (caseins) leads to the formation of key-flavour components, which contribute to the sensory perception of dairy products. More specifically, caseins are degraded into peptides and amino acids and the latter are major precursors for volatile aroma compounds. In particular, the conversion ...
Tópico(s): Meat and Animal Product Quality
2005 - Oxford University Press | FEMS Microbiology Reviews
Jörg Smits, Bart Mertens, Hans C. van Houwelingen, Axel Haverich, Guido G. Persijn, Günther Laufer,
This study was undertaken to assess the influence of patient/donor and center factors on lung transplantation outcome. Outcomes of all consecutive first cadaveric lung transplants performed at 21 Eurotransplant centers in 1997–99 were analyzed. The risk-adjusted center effect on mortality was estimated. A Cox model was built including donor and recipient age and gender, primary disease, HLA mismatches, patient's residence, cold ischemic time, donor's cause of death, serum creatinine, type of lung ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2003 - Elsevier BV | American Journal of Transplantation
Joke A. M. Hunfeld, Christel W. Perquin, Wieke Bertina, Alice A.J.M. Hazebroek-Kampschreur, Lisette W. A. van Suijlekom‐Smit, Bart W. Koes, Johannes C. van der Wouden, Jan Passchier,
Objective Many juveniles with chronic pain of no known organic cause recover. Because adolescents whose pain persists may have chronic pain as adults, a subsample of 42 adolescents from a prevalence study in which continuation of their pain was observed throughout the study period was investigated quantitatively and qualitatively. All mothers (n = 42) completed a questionnaire on the impact of the adolescent's pain on the family. The authors tested the hypothesis that pain parameters, pain-related ...
Tópico(s): Musculoskeletal pain and rehabilitation
2002 - Lippincott Williams & Wilkins | Clinical Journal of Pain
Mandy S. J. Kater, Christiaan F. M. Huffels, Takuya Oshima, Niek S. Renckens, Jinte Middeldorp, Erik Boddeke, August B. Smit, Bart J. L. Eggen, Elly M. Hol, Mark H. G. Verheijen,
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, the neuropathological formation of amyloid-beta (Aβ) plaques and neurofibrillary tangles. The best cellular correlates of the early cognitive deficits in AD patients are synapse loss and gliosis. In particular, it is unclear whether the activation of microglia (microgliosis) has a neuroprotective or pathological role early in AD. Here we report that microgliosis is an early mediator of synaptic dysfunction ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2022 - Elsevier BV | Brain Behavior and Immunity
Evelien Schat, Francis Tuerlinckx, Arnout C. Smit, Bart De Ketelaere, Eva Ceulemans,
Detecting early warning signals of developing mood disorders in continuously collected affective experience sampling (ESM) data, would pave the way for timely intervention and prevention of a mood disorder from occurring or to mitigate its severity.However, there is an urgent need for online statistical methods tailored to the specifics of ESM data.Statistical process control (SPC) procedures, originally developed for monitoring industrial processes, seem promising tools.However, affective ESM data ...
Tópico(s): Advanced Statistical Process Monitoring
2021 - American Psychological Association | Psychological Methods
Marije Smit, Bart Koopman, Willem Dieperink, Jan B.F. Hulscher, H. Sijbrand Hofker, Matijs van Meurs, Jan G. Zijlstra,
Abstract Background Intra-abdominal hypertension is frequently present in critically ill patients and is an independent predictor for mortality. Risk factors for intra-abdominal hypertension and abdominal compartment syndrome have been widely investigated. However, data are lacking on prevalence and outcome in high-risk patients. Our objectives in this study were to investigate prevalence and outcome of intra-abdominal hypertension and abdominal compartment syndrome in high-risk patients in a prospective, ...
Tópico(s): Hernia repair and management
2020 - Springer Nature | Annals of Intensive Care
Marjolein Krul, Johannes C. van der Wouden, Emma J Kruithof, Lisette WA van Suijlekom-Smit, Bart W. Koes,
Pulled elbow (nursemaid's elbow) is a common injury in young children. It often results from a sudden pull on the arm, usually by an adult or taller person, which pulls the radius through the annular ligament, resulting in subluxation (partial dislocation) of the radial head. It can also be caused by a fall or twist. The child experiences sudden acute pain and loss of function in the affected arm. Pulled elbow is usually treated by manual reduction of the subluxed radial head. Various manoeuvres can ...
Tópico(s): Shoulder Injury and Treatment
2017 - Elsevier BV | Cochrane library
Gadissa Bedada Hundie, V. Stalin Raj, D. Gebre Michael, Suzan D. Pas, Marion Koopmans, Albert D. M. E. Osterhaus, Saskia L. Smits, Bart L. Haagmans,
Summary Hepatitis B virus ( HBV ) is genetically highly divergent and classified in ten genotypes and forty subgenotypes in distinct ethno‐geographic populations worldwide. Ethiopia is a country with high HBV prevalence; however, little is known about the genetic variability of HBV strains that circulate. Here, we characterize the complete genome of 29 HBV strains originating from five Ethiopian regions, by 454 deep sequencing and Sanger sequencing. Phylogenetically, ten strains were classified as genotype ...
Tópico(s): Vibrio bacteria research studies
2016 - Wiley | Journal of Viral Hepatitis
Gadissa Bedada Hundie, V. Stalin Raj, Daniel Gebre Michael, Suzan D. Pas, Albert D. M. E. Osterhaus, Marion Koopmans, Saskia L. Smits, Bart L. Haagmans,
Although hepatitis B virus (HBV) infection is hyperendemic in Ethiopia and constitutes a major public health problem, little is known about its genetic diversity, genotypes, and circulation. The aim of this study was to determine the molecular epidemiology and genetic diversity of HBV in Ethiopia, using 391 serum samples collected from HBsAg‐positive blood donors living in five different geographic regions. The HBV S/pol gene was amplified, sequenced, and HBV genotypes, subgenotypes, serotypes, and ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2015 - Wiley | Journal of Medical Virology
Andor F. van den Hoven, Maarten L. J. Smits, Bart de Keizer, Maarten S. van Leeuwen, Maurice A. A. J. van den Bosch, Marnix G. E. H. Lam,
Tópico(s): Liver Disease Diagnosis and Treatment
2014 - Springer Science+Business Media | CardioVascular and Interventional Radiology
Bénédicte Demaurex, Johannes P. Seif, Sjoerd Smit, Bart Macco, W. M. M. Kessels, Jonas Geissbühler, Stefaan De Wolf, Christophe Ballif,
We examine damage-free transparent-electrode deposition to fabricate high-efficiency amorphous silicon/crystalline silicon heterojunction solar cells. Such solar cells usually feature sputtered transparent electrodes, the deposition of which may damage the layers underneath. Using atomic layer deposition, we insert thin protective films between the amorphous silicon layers and sputtered contacts and investigate their effect on device operation. We find that a 20-nm-thick protective layer suffices ...
Tópico(s): Silicon Nanostructures and Photoluminescence
2014 - Institute of Electrical and Electronics Engineers | IEEE Journal of Photovoltaics
Berend‐Jan Bosch, Saskia L. Smits, Bart L. Haagmans,
Six coronaviruses, including the recently identified Middle East respiratory syndrome coronavirus, are known to target the human respiratory tract causing mild to severe disease. Their interaction with receptors expressed on cells located in the respiratory tract is an essential first step in the infection. Thus far three membrane ectopeptidases, dipeptidyl peptidase 4 (DPP4), angiotensin-converting enzyme 2 (ACE2) and aminopeptidase N (APN), have been identified as entry receptors for four human-infecting ...
Tópico(s): Neuropeptides and Animal Physiology
2014 - Elsevier BV | Current Opinion in Virology
Marjolein Krul, Johannes C. van der Wouden, Lisette WA van Suijlekom‐Smit, Bart W. Koes,
Background Pulled elbow (nursemaid's elbow) is a common injury in young children. It results from a sudden pull on the arm, usually by an adult or taller person, which pulls the radius through the annular ligament, resulting in subluxation (partial dislocation) of the radial head. The child experiences sudden acute pain and loss of function in the affected arm. Pulled elbow is usually treated by manual reduction of the subluxed radial head. Various manoeuvres can be applied. Most textbooks recommend ...
Tópico(s): Pediatric Pain Management Techniques
2012 - Cochrane | Cochrane database of systematic reviews
William Smit, Bart Sabbe, Peter Prinzie,
The objective of this study was to investigate the internal consistency and the construct validity of the Dutch version of the Supports Intensity Scale (SIS-NL1.0; Buntinx 2006) in individuals with physical disabilities (N = 65). To investigate the construct validity, the relationship between SIS subscales and practical skills (Barthel Index; BI) was calculated. Support was provided for the internal consistency. The SIS subscales (except Behavior) had moderate to high intercorrelations and the SIS was ...
Tópico(s): Inclusion and Disability in Education and Sport
2011 - Springer Science+Business Media | Journal of Developmental and Physical Disabilities
Hermelijn H. Smits, Bart Everts, Franca C. Hartgers, Maria Yazdanbakhsh,
Developed countries are suffering from an epidemic rise in immunologic disorders, such as allergy-related diseases and certain autoimmunities. Several studies have demonstrated a negative association between helminth infections and inflammatory diseases (eg, allergy), providing a strong case for the involvement of helminth infections in this respect. However, some studies point in the opposite direction. The discrepancy may be explained by differences in frequency, dose, time, and type of helminth. ...
Tópico(s): Parasite Biology and Host Interactions
2010 - Springer Science+Business Media | Current Allergy and Asthma Reports
Marjolein Krul, Johannes C. van der Wouden, F.G. Schellevis, Lisette W. A. van Suijlekom‐Smit, Bart W. Koes,
PURPOSE The obesity epidemic in children is spreading at alarming rates. Because musculoskeletal problems can influence physical activity, we compared the frequency of musculoskeletal problems in overweight and obese children with that in normal-weight children. METHODS We performed a cross-sectional database and face-to-face interview study that included 2,459 children aged 2 to 17 years from Dutch family practices. We collected data on self-reported height and weight (body mass index), self-reported musculoskeletal ...
Tópico(s): Occupational Health and Performance
2009 - American Academy of Family Physicians | The Annals of Family Medicine
Marjolein Krul, Johannes C. van der Wouden, François Schellevis, Lisette W. A. van Suijlekom‐Smit, Bart W. Koes,
Background. The differential diagnosis of children with acute non-traumatic hip pathology varies from quite harmless conditions such as transient synovitis of the hip to more severe problems like Perthes' disease, slipped capital femoral epiphysis (SCFE) and life-threatening conditions such as septic arthritis of the hip. Objective. To provide population-based data on symptom presentation and incidence rates of non-traumatic acute hip pathology in family practice. Methods. We analysed data from a ...
Tópico(s): Orthopaedic implants and arthroplasty
2009 - Oxford University Press | Family Practice
A.J. Scholten, G.D.J. Smit, Bart A. De Vries, L.F. Tiemeijer, J.A. Croon, D.B.M. Klaassen, R. van Langevelde, Xin Li, Weimin Wu, G. Gildenblat,
The surface-potential-based compact MOS model PSP is reviewed with special emphasis to features of interest to analog and RF designers. Various aspects of the model are discussed, such as Gummel symmetry, capacitance reciprocity at V DS = 0 V, parasitic resistances, junction modeling, distortion modeling, and noise modeling. Examples from circuit design are used to illustrate the benefits of the PSP model.
Tópico(s): Semiconductor materials and devices
2009 - Institute of Electrical and Electronics Engineers | IEEE Journal of Solid-State Circuits
Marjolein Krul, Johannes C. van der Wouden, F.G. Schellevis, Lisette WA van Suijlekom‐Smit, Bart W. Koes,
In recent decades, studies on the management of common foot problems in children have suggested that in many cases, there is no indication for treatment. It is not known whether these studies have changed daily practice.Our aim was to establish and compare incidence and referral rates for foot problems in children in 1987 and 2001.A comparison was made of two large consecutive surveys in Dutch general practice performed in 1987 (86 577 children aged 0-17 years) and 2001 (87 952 children aged 0-17 ...
Tópico(s): Inclusion and Disability in Education and Sport
2009 - Oxford University Press | Family Practice
Ilse Smits, Bart Soenens, Maarten Vansteenkiste, Koen Luyckx, Luc Goossens,
Tópico(s): Jewish Identity and Society
2009 - Springer Science+Business Media | Journal of Youth and Adolescence
Ilse Smits, Bart Soenens, Koen Luyckx, Bart Duriez, Michael D. Berzonsky, Luc Goossens,
This study examined the relationships between crucial dimensions of perceived parenting (support, behavioral control, and psychological control) and the three identity styles defined by Berzonsky [Berzonsky, M. D. (1990). Self-construction over the life span: A process perspective on identity formation. Advances in Personal Construct Psychology, 1, 155-186.]. Each identity style was hypothesized to relate to a specific pattern of perceived parenting dimensions. Hypotheses were examined in a sample ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2008 - Wiley | Journal of Adolescence
Simon G. J. Mathijssen, Michael Cölle, Henrique L. Gomes, Edsger C. P. Smits, Bart de Boer, Iain McCulloch, P. A. Bobbert, D.M. de Leeuw,
The electrical instability of organic field-effect transistors is investigated. We observe that the threshold-voltage shift (see figure) shows a stretched- exponential time dependence under an applied gate bias. The activation energy of 0.6 eV is common for our and all other organic transistors reported so far. The constant activation energy supports charge trapping by residual water as the common origin.
Tópico(s): Semiconductor materials and devices
2007 - | Advanced Materials
Robbert SA Mohammedamin, Johannes C. van der Wouden, Sander Koning, Michiel W. van der Linden, François Schellevis, Lisette WA van Suijlekom-Smit, Bart W. Koes,
Abstract Background The increasing proportion of skin diseases encountered in general practice represents a substantial part of morbidity in children. Only limited information is available about the frequency of specific skin diseases. We aimed to compare incidence rates of skin diseases in children in general practice between 1987 and 2001. Methods We used data on all children aged 0–17 years derived from two consecutive surveys performed in Dutch general practice in 1987 and 2001. Both surveys ...
Tópico(s): Dermatology and Skin Diseases
2006 - Springer Science+Business Media | BMC Dermatology
Marleen Smits, Bart van den Borne, Anton J. M. Dijker, Richard M. Ryckman,
Background: This study assessed the effects of an educational programme about organ donation delivered by (ex-)patients with a successfully transplanted donor kidney on the willingness of adolescents to register their organ donation preference. Methods: A total of 319 secondary school students were randomly assigned to a control group who received no specific educational information about organ donation or to an experimental group who received a 45-min lesson provided by an (ex-)patient. The lesson ...
Tópico(s): Reproductive Health and Technologies
2005 - Oxford University Press | European Journal of Public Health
Vivian Merlijn, Joke A. M. Hunfeld, Johannes C. van der Wouden, Alice A.J.M. Hazebroek-Kampschreur, Lisette W. A. van Suijlekom‐Smit, Bart W. Koes, Jan Passchier,
The purpose of this pilot study is to evaluate the feasibility of a cognitive-behavioural training program for adolescents with chronic pain irrespective of pain localisation. A secondary aim was to give an impression of the effect of the program on pain and quality of life. Eight adolescents (14–18 years) with chronic non-organic pain recruited from the general population (and their parents) participated in this pilot study. The intervention included five group meetings alternated with four telephone ...
Tópico(s): Infant Development and Preterm Care
2005 - Elsevier BV | Patient Education and Counseling
Hanneke Otters, Johannes C. van der Wouden, François Schellevis, Lisette WA van Suijlekom-Smit, Bart W. Koes,
Objectives: To examine the presentation and pattern of childhood morbidity in general practice compared with 14 years ago.Methods: We used data of all children aged 0–17 years from two cross-sectional surveys performed in 1987 and 2001 in general practice in the Netherlands. The total number of children in the practices participating in these surveys were 86,577 children in 1987 and 82,053 children in 2001. First of all, we compared consultation rates of children in general practice. Secondly, childhood ...
Tópico(s): Health and Medical Studies
2005 - Taylor & Francis | European Journal of General Practice
Anne Hagemeijer, Arjan Buijs, E.M.E. Smit, Bart Janssen, Geert‐Jan Creemers, D van der Plas, Gerard C. Grosveld,
Abstract Leukemic cells from two patients with Philadelphia‐negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M‐BCR region and formation of BCR‐ABL fusion mRNA with b2a2 (patient I) or b3a2 (patient 2) configuration, and 3) fluorescence in situ hybridization (FISH) demonstrated relocation of the 5′ BCR sequences from one chromosome 22 to one chromosome 9. The ABL probe hybridized ...
Tópico(s): Eosinophilic Disorders and Syndromes
1993 - Wiley | Genes Chromosomes and Cancer
Alexander R. Cools, Johannes M.M. Coolen, Johannes C.A. Smit, Bart Ellenbroek,
Tópico(s): Functional Brain Connectivity Studies
1984 - Elsevier BV | European Journal of Pharmacology
Gerrit Smit, Johan E. T. van Hylckama Vlieg, Bart Smit, Eman Ayad, Wim Engels,
Flavour development in dairy fermentations results from a series of (bio)chemical processes in which the starter cultures provide the enzymes. Particularly the enzymatic degradation of proteins (caseins) leads to the formation of key-flavour components, which contribute to the sensory perception of dairy products. More specifically, caseins are degraded into peptides and amino acids and the latter are major precursors for volatile aroma compounds. In particular, the conversion of methionine, the aromatic ...
Tópico(s): Polyamine Metabolism and Applications
2002 - | Australian Journal of Dairy Technology