Cristina Gavina, Inês Falcão‐Pires, J Rodrigues, Benjamim Marinho, Nádia Gonçalves, Ricardo J. Lopes, Mário Jorge Amorim, Jorge Almeida, Paulo Pinho, Alexandra Gonçalves, Francisco Rocha‐Gonçalves, Adelino Leite‐Moreira,
We evaluated the impact of hypertension on the left ventricular mass regression in aortic stenosis after aortic valve replacement.We prospectively studied 135 patients with severe aortic stenosis at baseline and 1 year after surgery. In 32 patients we analyzed myocardial gene expression of collagen types I and III, connective tissue growth factor, transforming growth factor-β1, metalloproteinase-2 and its tissue inhibitor and compared its levels vs controls.Seventy-six patients (56.3%) had a history ...
Tópico(s): Aortic Disease and Treatment Approaches
2013 - Elsevier BV | International Journal of Cardiology
Cristina Gavina, Inês Falcão‐Pires, João Santos-Faria, Benjamim Marinho, Jorge Almeida, J Rodrigues, Paulo Pinho, Francisco Rocha‐Gonçalves, Adelino Leite‐Moreira,
Among patients with aortic stenosis (AS), interstitial fibrosis has been associated with progression to heart failure and is a marker of poorer prognosis. We aimed to assess the impact of myocardial fibrosis on clinical events after aortic valve replacement (AVR) in low risk, severe AS. We prospectively followed 56 severe AS patients with ejection fraction >40%, who underwent AVR with simultaneous myocardial biopsies and collagen volume fraction (CVF) determination. Baseline and follow-up echocardiographic ...
Tópico(s): Cardiovascular Function and Risk Factors
2021 - Elsevier BV | Revista Portuguesa de Cardiologia