Marco P. Licciardello, Markus K. Müllner, Gerhard Dürnberger, Claudia Kerzendorfer, Bernd Boidol, Claudia Jessen‐Trefzer, Sara Sdelci, Tobias Berg, Thomas Penz, Michael Schuster, Christoph Bock, Róbert Královics, Giulio Superti‐Furga, Jacques Colinge, Sebastian Nijman, Stefan Kubicek,
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel of engineered breast epithelial cell lines. Here we report a selective interaction between the NOTCH1 signaling pathway and the SUMOylation cascade. Knockdown of the E2-conjugating enzyme UBC9 (UBE2I) as ...
Tópico(s): Glycosylation and Glycoproteins Research
2014 - Springer Nature | Oncogene
Marco P. Licciardello, Anna Ringler, Patrick Markt, Freya Klepsch, Charles-Hugues Lardeau, Sara Sdelci, Erika Schirghuber, André C. Müller, Michael Caldera, Anja Wagner, Rebecca Herzog, Thomas Penz, Michael Schuster, Bernd Boidol, Gerhard Dürnberger, Yasin Folkvaljon, Pär Stattin, Vladimir N. Ivanov, Jacques Colinge, Christoph Bock, Klaus Kratochwill, Jörg Menche, Keiryn L. Bennett, Stefan Kubicek,
Tópico(s): Pharmacogenetics and Drug Metabolism
2017 - Nature Portfolio | Nature Chemical Biology