Cyndia Azucena González-Arias, Alma Betsaida Benítez-Trinidad, Monserrat Sordo, Lourdes Robledo-Marenco, Irma Martha Medina‐Díaz, Briscia Socorro Barrón-Vivanco, Sonia Marı́n, Vicente Sanchís, Antonio J. Ramos, Aurora Elizabeth Rojas‐García,
Tópico(s): Plant Disease Resistance and Genetics
2014 - Elsevier BV | Food and Chemical Toxicology
I E Pérez-González, María Guadalupe Prado-Ochoa, Marco Antonio Muñoz-Guzmán, Víctor Hugo Vázquez‐Valadez, Ana María Velázquez‐Sánchez, Betsaida Avila‐Suárez, César Cuenca-Verde, Enrique Ángeles, Fernando Alba-Hurtado,
The effects of six new synthetic carbamates on fully engorged females of four Rhipicephalus microplus strains (one reference strain susceptible to conventional ixodicides, two strains multiresistant to ixodicides and one tick field isolate) were compared. In addition, the effect of two other new synthetic carbamates was tested on larvae from the same strains. The first six tested carbamates reduced egg laying and inhibited egg hatching in the four studied strains (P < 0.05). Compared with untreated ...
Tópico(s): Insect Pest Control Strategies
2013 - Elsevier BV | Veterinary Parasitology
Alma Betsaida Benítez-Trinidad, José Francisco Herrera‐Moreno, G. Vázquez-Estrada, Francisco Alberto Verdín-Betancourt, M. Sordo, Patricia Ostrosky‐Wegman, Yael Yvette Bernal-Hernández, Irma Martha Medina‐Díaz, Briscia Socorro Barrón-Vivanco, M.L. Robledo-Marenco, Ana María Salazar, Aurora Elizabeth Rojas‐García,
Temephos is an organophosphorus pesticide that is used in control campaigns against Aedes aegypti mosquitoes, which transmit dengue. In spite of the widespread use of temephos, few studies have examined its genotoxic potential. The aim of this study was to evaluate the cytotoxic, cytostatic and genotoxic effects of temephos in human lymphocytes and hepatoma cells (HepG2). The cytotoxicity was evaluated with simultaneous staining (FDA/EtBr). The cytostatic and genotoxic effects were evaluated using ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2015 - Elsevier BV | Toxicology in Vitro
Betsaida Bibo‐Verdugo, Liliana Rojo‐Arreola, Maria A. Navarrete-del-Toro, Fernando García‐Carreño,
Tópico(s): Environmental Toxicology and Ecotoxicology
2015 - Springer Science+Business Media | Marine Biotechnology
Susana Mingo Santos, Vanessa Moñivas‐Palomero, Inés García‐Lunar, Cristina Mitroi, Josebe Goirigolzarri Artaza, Betsaida Rivero, J. Domínguez, Evaristo Castedo, Jesús G. Mirelis, Miguel Ángel Broc Cavero, Manuel Gómez‐Bueno, Javier Segovia, Luis Alonso-Pulpón,
Acute cellular rejection (ACR) is still a relevant complication after orthotopic heart transplantation. The diagnosis of ACR is based on endomyocardial biopsy (EMB). Recent advances in two-dimensional strain imaging may allow early noninvasive detection of ACR. The objective of this study was to analyze the usefulness of conventional and new echocardiographic parameters to exclude ACR after orthotopic heart transplantation.Thirty-four consecutive adult heart transplant recipients admitted to a single ...
Tópico(s): Cardiac Structural Anomalies and Repair
2015 - Elsevier BV | Journal of the American Society of Echocardiography
R.D. Zepeda-Arce, Aurora Elizabeth Rojas‐García, Alma Betsaida Benítez-Trinidad, José Francisco Herrera‐Moreno, Irma Martha Medina‐Díaz, Briscia Socorro Barrón-Vivanco, Germán Pier Villegas, Isabel Hernández‐Ochoa, María de Jesús Sólis Heredia, Yael Yvette Bernal-Hernández,
The indiscriminate use of pesticides in agriculture and public health campaigns has been associated with an increase of oxidative stress and DNA damage, resulting in health outcomes. Some defense mechanisms against free radical-induced oxidative damage include the antioxidant enzyme systems. The aim of this study was to determine the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and the relationship of antioxidant ...
Tópico(s): Air Quality and Health Impacts
2017 - Wiley | Environmental Toxicology
Betsaida Bibo‐Verdugo, Zhenze Jiang, Conor R. Caffrey, Anthony J. O’Donoghue,
Proteasomes are multisubunit, energy‐dependent, proteolytic complexes that play an essential role in intracellular protein turnover. They are present in eukaryotes, archaea, and in some actinobacteria species. Inhibition of proteasome activity has emerged as a powerful strategy for anticancer therapy and three drugs have been approved for treatment of multiple myeloma. These compounds react covalently with a threonine residue located in the active site of a proteasome subunit to block protein degradation. ...
Tópico(s): Cytomegalovirus and herpesvirus research
2017 - Wiley | FEBS Journal
Gregory LaMonte, Jehad Almaliti, Betsaida Bibo‐Verdugo, Lena Keller, Bing Zou, Jennifer H. Yang, Yevgeniya Antonova‐Koch, Pamela Orjuela-Sánchez, Colleen A. Boyle, Edgar Vigil, Lawrence Wang, Gregory M. Goldgof, Lena Gerwick, Anthony J. O’Donoghue, Elizabeth A. Winzeler, William H. Gerwick, Sabine Ottilie,
Naturally derived chemical compounds are the foundation of much of our pharmacopeia, especially in antiproliferative and anti-infective drug classes. Here, we report that a naturally derived molecule called carmaphycin B is a potent inhibitor against both the asexual and sexual blood stages of malaria infection. Using a combination of in silico molecular docking and in vitro directed evolution in a well-characterized drug-sensitive yeast model, we determined that these compounds target the β5 subunit ...
Tópico(s): HIV Research and Treatment
2017 - American Chemical Society | Journal of Medicinal Chemistry
Alma Betsaida Benítez-Trinidad, Irma Martha Medina‐Díaz, Yael Yvette Bernal-Hernández, Briscia Socorro Barrón-Vivanco, Cyndia Azucena González-Arias, José Francisco Herrera‐Moreno, Isabel Alvarado-Cruz, Betzabet Quintanilla‐Vega, Aurora Elizabeth Rojas‐García,
Tópico(s): Glutathione Transferases and Polymorphisms
2018 - Elsevier BV | Food and Chemical Toxicology
Produção Nacional
Revisado por pares
Rafael A Carvalho, Betsaida Urtremari, Alexander A.L. Jorge, Lucas Santos de Santana, Elisangela P S Quedas, Tomoko Sekiya, Viviane C. Longuini, Fábio Luiz de Menezes Montenegro, Antônio Marcondes Lerário, S. P. A. Toledo, Stephen J. Marx, Rodrigo A. Toledo, Delmar Muniz Lourenço,
Background Loss-of-function germline MEN1 gene mutations account for 75-95% of patients with multiple endocrine neoplasia type 1 (MEN1). It has been postulated that mutations in non-coding regions of MEN1 might occur in some of the remaining patients; however, this hypothesis has not yet been fully investigated. Objective To sequence for the entire MEN1 including promoter, exons and introns in a large MEN1 cohort and determine the mutation profile. Methods and patients A target next-generation sequencing ( ...
Tópico(s): Neuroblastoma Research and Treatments
2018 - Oxford University Press | European Journal of Endocrinology
Betsaida Bibo‐Verdugo, Steven C Wang, Jehad Almaliti, Anh P. Ta, Zhenze Jiang, Derek A. Wong, Christopher B. Lietz, Brian M. Suzuki, Nelly El‐Sakkary, Vivian Hook, Guy S. Salvesen, William H. Gerwick, Conor R. Caffrey, Anthony J. O’Donoghue,
Proteases are fundamental to successful parasitism, including that of the schistosome flatworm parasite, which causes the disease schistosomiasis in 200 million people worldwide. The proteasome is receiving attention as a potential drug target for treatment of a variety of infectious parasitic diseases, but it has been understudied in the schistosome. Adult Schistosoma mansoni were incubated with 1 μM concentrations of the proteasome inhibitors bortezomib, carfilzomib, and MG132. After 24 h, bortezomib ...
Tópico(s): Trypanosoma species research and implications
2019 - American Chemical Society | ACS Infectious Diseases
Anthony J. O’Donoghue, Betsaida Bibo‐Verdugo, Yukiko Miyamoto, Steven C Wang, Justin Yang, Douglas E. Zuill, Shoun Matsuka, Zhenze Jiang, Jehad Almaliti, Conor R. Caffrey, William H. Gerwick, Lars Eckmann,
Trichomoniasis is a sexually transmitted disease with hundreds of millions of annual cases worldwide. Approved treatment options are limited to two related nitro-heterocyclic compounds, yet resistance to these drugs is an increasing concern. New antimicrobials against the causative agent, Trichomonas vaginalis, are urgently needed. We show here that clinically approved anticancer drugs that inhibit the proteasome, a large protease complex with a critical role in degrading intracellular proteins ...
Tópico(s): Herpesvirus Infections and Treatments
2019 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Betsaida Bibo‐Verdugo, Scott J. Snipas, Sonia Kołt, Marcin Poręba, Guy S. Salvesen,
Pyroptosis is the caspase-dependent inflammatory cell death mechanism that underpins the innate immune response against pathogens and is dysregulated in inflammatory disorders. Pyroptosis occurs via two pathways: the canonical pathway, signaled by caspase-1, and the noncanonical pathway, regulated by mouse caspase-11 and human caspase-4/5. All inflammatory caspases activate the pyroptosis effector protein gasdermin D, but caspase-1 mostly activates the inflammatory cytokine precursors prointerleukin- ...
Tópico(s): Streptococcal Infections and Treatments
2020 - Elsevier BV | Journal of Biological Chemistry
Ana S. González-Reiche, Matthew M. Hernandez, Mitchell J. Sullivan, Brianne Ciferri, Hala Alshammary, Ajay Obla, Shelcie Fabre, Giulio Kleiner, José Polanco, Zenab Khan, Bremy Alburquerque, Adriana van de Guchte, Jayeeta Dutta, Nancy Francoeur, Betsaida Salom Melo, Irina Oussenko, Gintaras Deikus, Juan Soto, Shwetha Hara Sridhar, Ying‐Chih Wang, Kathryn Twyman, Andrew Kasarskis, Deena R. Altman, Melissa Smith, Robert Sebra, Judith A. Aberg, Florian Krammer, Adolfo Garcı́a-Sastre, Marta Łuksza, Gopi Patel, Alberto Paniz‐Mondolfi, Melissa Gitman, Emilia Mia Sordillo, Viviana Simon, Harm van Bakel,
Blighted Gotham Deaths caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in New York City (NYC) during the spring of 2020 have vastly exceeded those reported in China and many other countries. What were the early events that led to such a severe outbreak? Gonzalez-Reiche et al. sampled some of the early patients seeking assistance in February and March of 2020 at the Mount Sinai Health System. Phylogenetic analysis of virus sequences in these people, who were drawn from across ...
Tópico(s): Data-Driven Disease Surveillance
2020 - American Association for the Advancement of Science | Science
Produção Nacional
Revisado por pares
Oscar A. Pérez‐Escobar, Diego Bogarín, Natalia A. S. Przelomska, James D. Ackerman, Juan Antonio Balbuena, Sidonie Bellot, Roland P. Bühlmann, Betsaida Cabrera, Jose Aguilar Cano, Martha Charitonidou, Guillaume Chomicki, Mark A. Clements, Phillip Cribb, Melania Fernández, Nicola S. Flanagan, Barbara Gravendeel, Eric Hágsater, John M. Halley, Ai‐Qun Hu, Carlos Jaramillo, Anna Victória Silvério Righetto Mauad, Olivier Maurin, Robert Müntz, Ilia J. Leitch, Lan Li, Raquel Negrão, Lizbeth Oses, Charlotte Phillips, Milton Rincón-González, Gerardo A. Salazar, Lalita Simpson, Eric de Camargo Smidt, Rodolfo Solano, Edicson Parra‐Sánchez, Raymond L. Tremblay, Cássio van den Berg, Boris Stefan Villanueva Tamayo, Alejandro Zuluaga, Alexandre R. Zuntini, Mark W. Chase, Michael F. Fay, Fabien L. Condamine, Félix Forest, Katharina Nargar, Susanne S. Renner, William J. Baker, Alexandre Antonelli,
Orchids constitute one of the most spectacular radiations of flowering plants. However, their origin, spread across the globe, and hotspots of speciation remain uncertain due to the lack of an up-to-date phylogeographic analysis. We present a new Orchidaceae phylogeny based on combined high-throughput and Sanger sequencing data, covering all five subfamilies, 17/22 tribes, 40/49 subtribes, 285/736 genera, and c. 7% (1921) of the 29 524 accepted species, and use it to infer geographic range evolution, ...
Tópico(s): Plant and Fungal Species Descriptions
2024 - Wiley | New Phytologist
Denis Torre, Nancy Francoeur, Yael Kalma, Ilana Gross Carmel, Betsaida Salom Melo, Gintaras Deikus, Kimaada Allette, Ron Flohr, Maya Fridrikh, Konstantinos Vlachos, Kent Madrid, Hardik Shah, Ying‐Chih Wang, Shwetha Hara Sridhar, Melissa Smith, Efrat Eliyahu, Foad Azem, Hadar Amir, Yoav Mayshar, Ivan Marazzi, Ernesto Guccione, Eric E. Schadt, Dalit Ben‐Yosef, Robert Sebra,
Abstract Human preimplantation development involves extensive remodeling of RNA expression and splicing. However, its transcriptome has been compiled using short-read sequencing data, which fails to capture most full-length mRNAs. Here, we generate an isoform-resolved transcriptome of early human development by performing long- and short-read RNA sequencing on 73 embryos spanning the zygote to blastocyst stages. We identify 110,212 unannotated isoforms transcribed from known genes, including highly ...
Tópico(s): MicroRNA in disease regulation
2023 - Nature Portfolio | Nature Communications
Jessica Ho, Bobo Wing-Yee Mok, Laura Campisi, Tristan X. Jordan, Soner Yildiz, Sreeja Parameswaran, Joseph A. Wayman, Natasha N. Gaudreault, David A. Meekins, Sabarish V. Indran, Igor Morozov, Jessie D. Trujillo, Yesai Fstkchyan, Raveen Rathnasinghe, Zeyu Zhu, Simin Zheng, Nan Zhao, Kris M. White, Helen Ray-Jones, Valeriya Malysheva, Michiel J. Thiecke, S. Lau, Honglian Liu, Anna Junxia Zhang, Andrew Chak-Yiu Lee, Wen‐Chun Liu, Sonia Jangra, Alba Escalera, Teresa Aydillo, Betsaida Salom Melo, Ernesto Guccione, Robert Sebra, Elaine Shum, Jan Bakker, David A. Kaufman, André L. Moreira, Mariano Carossino, Udeni B. R. Balasuriya, Minji Byun, Randy A. Albrecht, Michael Schotsaert, Adolfo Garcı́a-Sastre, Sumit K. Chanda, Emily R. Miraldi, Anand D. Jeyasekharan, Benjamin R. tenOever, Mikhail Spivakov, Matthew T. Weirauch, Sven Heinz, Honglin Chen, Christopher Benner, Jüergen A. Richt, Ivan Marazzi,
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-inflammatory factors are associated with both increased disease severity and mortality. Here, using multidimensional epigenetic, transcriptional, in vitro, and in vivo analyses, we report that topoisomerase 1 (TOP1) inhibition suppresses lethal inflammation induced ...
Tópico(s): Phagocytosis and Immune Regulation
2021 - Cell Press | Cell
Zsofia Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo‐Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Søren Warming, Lucy A. Weinert, Clare Bryant,
Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly understood. Here, we describe a progressive evolutionary downregulation of pathogen-sensing inflammasome pathways in Carnivora. This includes the loss of nucleotide-oligomerization domain leucine-rich repeat receptors (NLRs), acquisition of a unique caspase-1/-4 ...
Tópico(s): Bartonella species infections research
2021 - Cell Press | Cell Reports
Javier Andreu-Pérez, Humberto Pérez-Espinosa, Eva Timonet‐Andreu, Mehrin Kiani, Manuel Iván Girón‐Pérez, Alma Betsaida Benítez-Trinidad, Delaram Jarchi, Alejandro Rosales-Pérez, Nick Gatzoulis, Orion F. Reyes-Galaviz, Alejandro A. Torres-García, Carlos A. Reyes-García, Zulfiqar Ali, Francisco Rivas-Ruíz,
In an attempt to reduce the infection rate of the COrona VIrus Disease-19 (Covid-19) countries around the world have echoed the exigency for an economical, accessible, point-of-need diagnostic test to identify Covid-19 carriers so that they (individuals who test positive) can be advised to self isolate rather than the entire community. Availability of a quick turn-around time diagnostic test would essentially mean that life, in general, can return to normality-at-large. In this regards, studies concurrent ...
Tópico(s): Respiratory viral infections research
2021 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Services Computing
Karina Janice Guadalupe Díaz‐Reséndiz, Carlos Eduardo Covantes‐Rosales, Alma Betsaida Benítez-Trinidad, Migdalia Sarahy Navidad-Murrieta, Francisco Fabián Razura-Carmona, Christian Daniel Carrillo-Cruz, Edwin Jaime Frias-Delgadillo, Daniela Alejandra Pérez-Díaz, Matxil Violeta Díaz-Benavides, Mercedes Zambrano-Soria, Guadalupe Herminia Ventura‐Ramón, Aurelio Romero‐Castro, David Alam-Escamilla, Manuel Iván Girón‐Pérez,
Fucoidan is a polysaccharide obtained from marine brown algae, with anti-inflammatory, anti-viral, and immune-enhancing properties, thus, fucoidan may be used as an alternative treatment (complementary to prescribed medical therapy) for COVID-19 recovery. This work aimed to determine the ex-vivo effects of treatment with fucoidan (20 µg/mL) on mitochondrial membrane potential (ΔΨm, using a cationic cyanine dye, 3,3'-dihexyloxacarbocyanine iodide (DiOC
Tópico(s): Vitamin C and Antioxidants Research
2022 - Multidisciplinary Digital Publishing Institute | Marine Drugs
Betsaida Bibo‐Verdugo, Guy S. Salvesen,
Regulated cell death is defined as genetically encoded pathways that lead towards the demise of cells. In mammals, cell demise can be either inflammatory or non-inflammatory, depending on whether the mechanism of death results in cell rupture or not. Inflammatory cell death can lead towards acute and chronic disease. Therefore, it becomes important to distinguish the mechanisms that result in these different inflammatory cell death outcomes. Apoptosis is a non-inflammatory form of cell death where ...
Tópico(s): interferon and immune responses
2022 - Elsevier BV | Molecular Aspects of Medicine
Karina Janice Guadalupe Díaz‐Reséndiz, Alma Betsaida Benítez-Trinidad, Carlos Eduardo Covantes‐Rosales, Gladys Alejandra Toledo‐Ibarra, Pablo César Ortiz-Lazareno, Daniel Alberto Girón‐Pérez, Adela Yolanda Bueno-Durán, Daniela Alejandra Pérez-Díaz, Rocio Guadalupe Barcelos-García, Manuel Iván Girón‐Pérez,
Abstract The mitochondrial membrane potential (ΔΨm) is a parameter often used to determine mitochondrial function; therefore, it can be used to determine the integrity and functionality of cells. A decrement of ΔΨm is implicated in several inflammatory-related pathologies, such phenomena can be related to COVID-19 infection. The present work aimed to compare the ΔΨm in leucocytes (human PBMCs; HPBMC) isolated from healthy control (HC) subjects, patients with COVID-19 (C-19), recovered subjects at 40 ± ...
Tópico(s): Infectious Encephalopathies and Encephalitis
2022 - Oxford University Press | Journal of Leukocyte Biology
Manisha Kak Korb, Allison Peck, Lindsay N. Alfano, Kenneth I. Berger, M. James, Nupur Ghoshal, Elise Healzer, Claire Henchcliffe, Shaida Khan, Pradeep P.A. Mammen, Sujata Patel, Gerald Pfeffer, Stuart H. Ralston, Bhaskar Roy, William W. Seeley, Andrea Swenson, Tahseen Mozaffar, Conrad C. Weihl, Virginia Kimonis, Roberto D. Fanganiello, Grace Lee, Ryan Patrick Mahoney, Jordi Díaz‐Manera, Teresinha Evangelista, Miriam Freimer, Thomas E. Lloyd, Benison Keung, Hani Kushlaf, Margherita Milone, Merrilee Needham, Johanna Palmio, Tanya Stojkovic, Rocío‐Nur Villar‐Quiles, Leo H. Wang, Matthew Wicklund, Frederick R. Singer, Mallory Jones, Bruce L. Miller, S. Ahmad Sajjadi, André Obenaus, Michael D. Geschwind, Ammar Al‐Chalabi, James Wymer, Nita Chen, Katie Kompoliti, Stephani C. Wang, Catherine A. Boissoneault, Betsaida Cruz-Coble, Kendrea L. Garand, Anna J. Rinholen, Lauren Tabor Gray, Jeffrey Rosenfeld, Ming Guo, Nathan Peck,
Abstract Valosin-containing protein (VCP) associated multisystem proteinopathy (MSP) is a rare inherited disorder that may result in multisystem involvement of varying phenotypes including inclusion body myopathy, Paget’s disease of bone (PDB), frontotemporal dementia (FTD), parkinsonism, and amyotrophic lateral sclerosis (ALS), among others. An international multidisciplinary consortium of 40+ experts in neuromuscular disease, dementia, movement disorders, psychology, cardiology, pulmonology, physical ...
Tópico(s): Amyotrophic Lateral Sclerosis Research
2022 - BioMed Central | Orphanet Journal of Rare Diseases
Produção Nacional
Revisado por pares
Claudia Garnica‐Díaz, Rosalina Berazaín Iturralde, Betsaida Cabrera, E. M., Fermín L. Felipe, Ricardo Garcı́a, José Luis Gómez Hechavarría, Aretha Franklin Guimarães, Ernesto Medina, Adrian L. D. Paul, Nishanta Rajakaruna, Carla Restrepo, Stefan J. Siebert, Eduardo van den Berg, Antony van der Ent, Grisel Velásquez, Catherine M. Hulshof,
Tópico(s): Plant Taxonomy and Phylogenetics
2022 - Springer Science+Business Media | The Botanical Review
Produção Nacional
Revisado por pares
Adla Betsaida Martins Teixeira, C. Villani, Silvânia Sousa do Nascimento,
The objective of this study was to identify gender issues in the academic performance of boys and girls during physics classes in a laboratory. The methodology adopted was the observation and interactions of pupils during eight classroom events. The interactions were recorded and events were informally discussed with the teacher. The school visited is a Federal mixed school, located in the city of Belo Horizonte, a large urban and industrialised area of Brazil. Boys and girls differed significantly ...
Tópico(s): Social Representations and Identity
2008 - Taylor & Francis | Gender and Education
Betsaida J. Ortiz‐Sánchez, Martha Legorreta‐Herrera, Miriam Rodríguez‐Sosa,
Periodontitis is an inflammatory disease that affects the supporting structures of teeth. The presence of a bacterial biofilm initiates a destructive inflammatory process orchestrated by various inflammatory mediators, most notably proinflammatory cytokines, which are upregulated in the gingival crevicular fluid, leading to the formation of periodontal pockets. This represents a well-characterized microbial change during the transition from periodontal health to periodontitis; interestingly, the ...
Tópico(s): Inflammatory mediators and NSAID effects
2021 - Hindawi Publishing Corporation | Mediators of Inflammation
Betsaida Bibo‐Verdugo, Anthony J. O’Donoghue, Liliana Rojo‐Arreola, Charles S. Craik, Fernando García‐Carreño,
Tópico(s): Peptidase Inhibition and Analysis
2015 - Springer Science+Business Media | Marine Biotechnology
María García‐Bonilla, Betsaida Ojeda-Pérez, Maria Luisa García‐Martín, M. Carmen Muñoz-Hernández, Javier Vitórica, Sebastián Jiménez, Manuel Cifuentes, Leonor Santos‐Ruiz, Kirill Shumilov, Silvia Claros, Antonia Gutiérrez, Patricia Páez, Antonio J. Jiménez,
Abstract Background In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial reactions in the neocortex. The viability and short time effects of a therapy based on bone marrow-derived mesenchymal stem cells (BM-MSC) have been evaluated in such pathological conditions in the hyh mouse model. Methods BM-MSC obtained from mice expressing fluorescent ...
Tópico(s): Spinal Dysraphism and Malformations
2020 - BioMed Central | Stem Cell Research & Therapy
Stephany Navarro, Habib Abla, Betsaida Delgado, Jane A. Colmer‐Hamood, Gary Ventolini, Abdul N. Hamood,
Glycogen metabolism by Lactobacillus spp. that dominate the healthy vaginal microbiome contributes to a low vaginal pH (3.5-4.5). During bacterial vaginosis (BV), strict and facultative anaerobes including Gardnerella vaginalis become predominant, leading to an increase in the vaginal pH (> 4.5). BV enhances the risk of obstetrical complications, acquisition of sexually transmitted infections, and cervical cancer. Factors critical for the maintenance of the healthy vaginal microbiome or the transition ...
Tópico(s): Gut microbiota and health
2023 - BioMed Central | BMC Microbiology
Daniel Alberto Girón‐Pérez, Rocío Alejandra Ruiz‐Manzano, Alma Betsaida Benítez-Trinidad, Guadalupe Herminia Ventura‐Ramón, Carlos Eduardo Covantes‐Rosales, Ansonny Jhovanny Ojeda-Durán, Ulises Mercado‐Salgado, Gladys Alejandra Toledo‐Ibarra, Karina Janice Guadalupe Díaz‐Reséndiz, Manuel Iván Girón‐Pérez,
Objective: To perform an improved large-scale SARS-CoV-2 detection on pooled tests of asymptomatic workers. Methods: qRT-PCR validation of the SARS-CoV-2 detection in salivae samples and saliva pools and working-group saliva pooling and testing for SARS-CoV-2. Results: We found a high Cycle threshold correlation ( r = 0.9099) between swabs and saliva samples. Then, through the pooling strategy, we detected that 18/360 (5%) of individual saliva samples were SARS-CoV-2 positive. Saliva-pooling efficiency ( ...
Tópico(s): Dental Research and COVID-19
2021 - Lippincott Williams & Wilkins | Journal of Occupational and Environmental Medicine