Shiraz Haron‐Khun, David Weisbrod, Hanna Bueno, Dor Yadin, Joachim A. Behar, Asher Peretz, Ofer Binah, Edith Hochhauser, Michael Eldar, Yael Yaniv, Michael Arad, Bernard Attali,
... Search for more papers by this author Ofer Binah Ofer Binah Department of Physiology, Ruth & Bruce Rappaport Faculty of ... Search for more papers by this author Ofer Binah Ofer Binah Department of Physiology, Ruth & Bruce Rappaport Faculty of ...
Tópico(s): Cardiac Arrhythmias and Treatments
2017 - Springer Nature | EMBO Molecular Medicine
Young-Jae Nam, Kartik Mani, Lily I. Wu, Chang-Fu Peng, John W. Calvert, Roger Foo, Barath Krishnamurthy, Wenfeng Miao, Anthony W. Ashton, David J. Lefer, Richard N. Kitsis,
... Shilkrut M. Lotan R. Berke G. Larisch S. Binah O. Cardiovasc. Res. 2002; 54: 611-623Crossref PubMed ... Google Scholar, 20Yaniv G. Shilkrut M. Larisch S. Binah O. Biochem. Biophys. Res. Commun. 2005; 336: 740- ... Shilkrut M. Lotan R. Berke G. Larisch S. Binah O. Cardiovasc. Res. 2002; 54: 611-623Crossref PubMed ... Google Scholar, 20Yaniv G. Shilkrut M. Larisch S. Binah O. Biochem. Biophys. Res. Commun. 2005; 336: 740- ...
Tópico(s): Mitochondrial Function and Pathology
2006 - Elsevier BV | Journal of Biological Chemistry
Scot J. Matkovich, Elizabeth A. Woodcock,
... G. Coleman R. Robinson R.B. Berke G. Binah O. Circ. Res. 1998; 82: 438-450Crossref PubMed ... Ref. 18.Woodcock E.A. Matkovich S.J. Binah O. Cardiovasc. Res. 1998; 40: 251-256Crossref PubMed ... heart (18.Woodcock E.A. Matkovich S.J. Binah O. Cardiovasc. Res. 1998; 40: 251-256Crossref PubMed ... G. Coleman R. Robinson R.B. Berke G. Binah O. Circ. Res. 1998; 82: 438-450Crossref PubMed ...
Tópico(s): Calcium signaling and nucleotide metabolism
2000 - Elsevier BV | Journal of Biological Chemistry
Binah R. Silberstein, Zippora Gromet‐Elhanan,
... a possible primary electron acceptor in Rhodospirillum rubrum Binah R. Silberstein, Binah R. Silberstein Department of Biochemistry, Weizmann Institute of ... Rehovot, IsraelSearch for more papers by this author Binah R. Silberstein, Binah R. Silberstein Department of Biochemistry, Weizmann Institute of ...
Tópico(s): Algal biology and biofuel production
1974 - Wiley | FEBS Letters
Hèou Maléki Badjana, Jörg Helmschrot, Peter Selsam, Kpérkouma Wala, Wolfgang‐Albert Flügel, Abel Afouda, Koffi Akpagana,
... between 1972 and 2013 were investigated in the Binah River watershed (North of Togo and Benin) using ...
Tópico(s): Remote Sensing in Agriculture
2015 - American Geophysical Union | Earth and Space Science
... Ertracht O, Bachner‐Hinenzon N, Reiter I and Binah O (2016) The cardioprotective efficacy of TVP 1022 ... I, Shofti R, Youdim M, Abassi Z and Binah O (2015) TVP1022, Journal of Cardiovascular Pharmacology, 10. ...
Tópico(s): Signaling Pathways in Disease
2010 - Lippincott Williams & Wilkins | Circulation
Marie B. Marron, Harprit Singh, Tariq A. Tahir, Jais Kavumkal, Hak-Zoo Kim, Gou Young Koh, Nicholas P.J. Brindle,
... Y. Yahav H. Shay-Salit A. Zilberman M. Binah O. Resnick N. FASEB J. 2003; 17: 2121- ... Y. Yahav H. Shay-Salit A. Zilberman M. Binah O. Resnick N. FASEB J. 2003; 17: 2121- ...
Tópico(s): Angiogenesis and VEGF in Cancer
2007 - Elsevier BV | Journal of Biological Chemistry
Stephan E. Lehnart, Andrew R. Marks,
... I, Palty R, Arad M, Gottlieb E and Binah O (2021) Depressed β‐adrenergic inotropic responsiveness and ... A, Rodenburg R, Mandel H, Gherghiceanu M and Binah O (2017) Investigating the cardiac pathology of SCO2- ...
Tópico(s): Receptor Mechanisms and Signaling
2007 - Lippincott Williams & Wilkins | Circulation Research
Rumi Maruyama, Genzou Takemura, Takuma Aoyama, Kenji Hayakawa, Masahiko Koda, Yukinori Kawase, Xinbin Qiu, Yasushi Ohno, Shinya Minatoguchi, Kenji Miyata, Takako Fujiwara, Hisayoshi Fujiwara,
... Maor G Coleman R Robinson RB Berke G Binah O Fas (CD95/Apo-1)-mediated damage to ... Maor G Coleman R Robinson RB Berke G Binah O Fas (CD95/Apo-1)-mediated damage to ...
Tópico(s): PARP inhibition in cancer therapy
2001 - Elsevier BV | American Journal Of Pathology
... 9110, Waltham, M 02254-9110, USA. Email: hirsch@binah.cc.brandeis.eduSearch for more papers by this ... 9110, Waltham, M 02254-9110, USA. Email: hirsch@binah.cc.brandeis.eduSearch for more papers by this ...
Tópico(s): Embodied and Extended Cognition
1997 - Wiley | Mind & Language
... the introductory pages of the unpublished manuscript Divre binah (Understanding Words) by Dov Ber Birkenthal. Although the ...
Tópico(s): Polish-Jewish Holocaust Memory Studies
2009 - Cambridge University Press | AJS Review The Journal of the Association for Jewish Studies
Edward G. Lakatta, Yael Yaniv, Victor A. Maltsev,
... approved the final version of the manuscript.REFERENCES1. Binah O, Weissman A, Itskovitz-Eldor J, Rosen MR. ... S, Lorber A, Rosen MR, Itskovitz-Eldor J, Binah O. Human embryonic and induced pluripotent stem cell- ...
Tópico(s): Photoreceptor and optogenetics research
2013 - American Physical Society | AJP Cell Physiology
Rakefet Ackerman, Avital Binah-Pollak, Tirza Lauterman,
Success in cognitive tasks is associated with effort regulation and motivation. We employed the meta-reasoning approach to investigate metacognitive monitoring accuracy and effort regulation in problem solving across cultures. Adults from China, from Israel, and from Europe and North America (for simplicity: "Western countries") solved nonverbal problems and rated their confidence in their answers. The task involved identifying geometric shapes within silhouettes and, thus, required overcoming interference ...
Tópico(s): Creativity in Education and Neuroscience
2023 - Multidisciplinary Digital Publishing Institute | Journal of Intelligence
Eric N. Jiménez‐Vázquez, Michael Arad, Álvaro Macías, María Linarejos Vera-Pedrosa, Francisco M. Cruz, Lilian K. Gutiérrez, Ashley J. Cuttitta, André Monteiro da Rocha, Todd J. Herron, Daniela Ponce‐Balbuena, Guadalupe Guerrero‐Serna, Ofer Binah, Daniel E. Michele, José Jalife,
Patients with cardiomyopathy of Duchenne Muscular Dystrophy (DMD) are at risk of developing life-threatening arrhythmias, but the mechanisms are unknown. We aimed to determine the role of ion channels controlling cardiac excitability in the mechanisms of arrhythmias in DMD patients.
Tópico(s): Cardiomyopathy and Myosin Studies
2022 - eLife Sciences Publications Ltd | eLife
Paz Ovics, Danielle Regev, Polina Baskin, Mor Davidor, Yuval Shemer, Shunit Neeman, Yael Ben‐Haim, Ofer Binah,
Over the years, numerous groups have employed human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) as a superb human-compatible model for investigating the function and dysfunction of cardiomyocytes, drug screening and toxicity, disease modeling and for the development of novel drugs for heart diseases. In this review, we discuss the broad use of iPSC-CMs for drug development and disease modeling, in two related themes. In the first theme—drug development, adverse drug reactions, ...
Tópico(s): Neuroscience and Neural Engineering
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Stephanie Protze, Jee Hoon Lee, Gordon Keller,
... Segev H. Amit M. Gepstein A. Livne E. Binah O. Itskovitz-Eldor J. Gepstein L. Human embryonic ...
Tópico(s): Congenital heart defects research
2019 - Elsevier BV | Cell stem cell
Binyamin Eisen, Ronen Ben Jehuda, Ashley J. Cuttitta, Lucy N. Mekies, Yuval Shemer, Polina Baskin, Irina Reiter, Lubna Willi, Dov Freimark, Mihaela Gherghiceanu, Lorenzo Monserrat, Michaela Scherr, Denise Hilfiker‐Kleiner, Michael Arad, Daniel E. Michele, Ofer Binah,
Abstract Duchenne muscular dystrophy (DMD) is an X‐linked progressive muscle degenerative disease, caused by mutations in the dystrophin gene and resulting in death because of respiratory or cardiac failure. To investigate the cardiac cellular manifestation of DMD, we generated induced pluripotent stem cells (iPSCs) and iPSC‐derived cardiomyocytes (iPSC‐CMs) from two DMD patients: a male and female manifesting heterozygous carrier. Dystrophin mRNA and protein expression were analysed by qRT‐PCR, RNAseq, ...
Tópico(s): Pluripotent Stem Cells Research
2019 - Wiley | Journal of Cellular and Molecular Medicine
Melanie Ricke‐Hoch, Martijn F. Hoes, Tobias J. Pfeffer, Stella Schlothauer, Justus Nonhoff, Susanna Haidari, Nils Bömer, Michaela Scherr, Britta Stapel, Elisabeth Stelling, Yulia Kiyan, Christine S. Falk, Arash Haghikia, Ofer Binah, Zoltàn Arany, Thomas Thum, Johann Bauersachs, Peter van der Meer, Denise Hilfiker‐Kleiner,
Peripartum cardiomyopathy (PPCM) is a life-threatening heart disease occurring in previously heart-healthy women. A common pathomechanism in PPCM involves the angiostatic 16 kDa-prolactin (16 kDa-PRL) fragment, which via NF-κB-mediated up-regulation of microRNA-(miR)-146a induces vascular damage and heart failure. We analyse whether the plasminogen activator inhibitor-1 (PAI-1) is involved in the pathophysiology of PPCM.In healthy age-matched postpartum women (PP-Ctrl, n = 53, left ventricular ejection ...
Tópico(s): Kawasaki Disease and Coronary Complications
2019 - Oxford University Press | Cardiovascular Research
Ronen Ben Jehuda, Yuval Shemer, Ofer Binah,
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2018 - Springer Science+Business Media | Stem Cell Reviews and Reports
Revital Schick, Lucy N. Mekies, Yuval Shemer, Binyamin Eisen, Tova Hallas, Ronen Ben Jehuda, Meital Ben-Ari, Ágnes Szántai, Lubna Willi, Rita Shulman, Michael Gramlich, Luna Simona Pane, Ilaria My, Dov Freimark, Marta Murgia, Gianluca Santamaria, Mihaela Gherghiceanu, Michael Arad, Alessandra Moretti, Ofer Binah,
Aims Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathological mechanisms of DCM are unclear mainly due to numerous mutations in different gene families resulting in the same outcome—decreased ventricular function. Titin (TTN)—a giant protein, expressed in cardiac and skeletal muscles, is an important part of the ...
Tópico(s): Cardiovascular Effects of Exercise
2018 - Public Library of Science | PLoS ONE
Tova Hallas, Binyamin Eisen, Yuval Shemer, Ronen Ben Jehuda, Lucy N. Mekies, Shulamit Naor, Revital Schick, Sivan Eliyahu, Irina Reiter, Eugene Vlodavsky, Yeshayahu Katz, Katrin Õunap, Avraham Lorber, Richard J. Rodenburg, Hanna Mandel, Mihaela Gherghiceanu, Ofer Binah,
Abstract Mutations in SCO2 are among the most common causes of COX deficiency, resulting in reduced mitochondrial oxidative ATP production capacity, often leading to hypertrophic cardiomyopathy (HCM). To date, none of the recent pertaining reports provide deep understanding of the SCO2 disease pathophysiology. To investigate the cardiac pathology of the disease, we were the first to generate induced pluripotent stem cell (iPSC)‐derived cardiomyocytes (iPSC‐CMs) from SCO2‐mutated patients. For iPSC ...
Tópico(s): ATP Synthase and ATPases Research
2017 - Wiley | Journal of Cellular and Molecular Medicine
Samuel Chauveau, Evgeny P. Anyukhovsky, Meital Ben-Ari, Shulamit Naor, Yaping Jiang, Peter Danilo, Tania Rahim, Stephanie Burke, Xiaoliang Qiu, Irina A. Potapova, Sergey V. Doronin, Peter R. Brink, Ofer Binah, Ira S. Cohen, Michael R. Rosen,
Background— Although multiple approaches have been used to create biological pacemakers in animal models, induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) have not been investigated for this purpose. We now report pacemaker function of iPSC-CMs in a canine model. Methods and Results— Embryoid bodies were derived from human keratinocytes, their action potential characteristics determined, and their gene expression profiles and markers of differentiation identified. Atrioventricular ...
Tópico(s): CRISPR and Genetic Engineering
2017 - Lippincott Williams & Wilkins | Circulation Arrhythmia and Electrophysiology
Ronen Ben Jehuda, Binyamin Eisen, Yuval Shemer, Lucy N. Mekies, Ágnes Szántai, Irina Reiter, Huanhuan Cui, Kaomei Guan, Shiraz Haron‐Khun, Dov Freimark, Silke Sperling, Mihaela Gherghiceanu, Michael Arad, Ofer Binah,
Background Mutations in the PRKAG2 gene encoding the γ-subunit of adenosine monophosphate kinase (AMPK) cause hypertrophic cardiomyopathy (HCM) and familial Wolff-Parkinson-White (WPW) syndrome. Patients carrying the R302Q mutation in PRKAG2 present with sinus bradycardia, escape rhythms, ventricular preexcitation, supraventricular tachycardia, and atrioventricular block. This mutation affects AMPK activity and increases glycogen storage in cardiomyocytes. The link between glycogen storage, WPW syndrome, HCM, ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2017 - Elsevier BV | Heart Rhythm
Meital Ben-Ari, Shulamit Naor, Naama Zeevi‐Levin, Revital Schick, Ronen Ben Jehuda, Irina Reiter, Amit Raveh, Inna Grijnevitch, Omri Barak, Michael R. Rosen, Amir Weissman, Ofer Binah,
Previous studies proposed that throughout differentiation of human induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs), only 3 types of action potentials (APs) exist: nodal-, atrial-, and ventricular-like.To investigate whether there are precisely 3 phenotypes or a continuum exists among them, we tested 2 hypotheses: (1) During culture development a cardiac precursor cell is present that-depending on age-can evolve into the 3 phenotypes. (2) The predominant pattern is early prevalence of ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2016 - Elsevier BV | Heart Rhythm
Atara Novak, Lili Barad, Avraham Lorber, Mihaela Gherghiceanu, Irina Reiter, Binyamin Eisen, Liron Eldor, Joseph Itskovitz‐Eldor, Michael Eldar, Michael Arad, Ofer Binah,
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia characterized by syncope and sudden death occurring during exercise or acute emotion. CPVT is caused by abnormal intracellular Ca(2+) handling resulting from mutations in the RyR2 or CASQ2 genes. Because CASQ2 and RyR2 are involved in different aspects of the excitation-contraction coupling process, we hypothesized that these mutations are associated with different functional and intracellular Ca(²+) abnormalities. ...
Tópico(s): Cardiovascular Effects of Exercise
2015 - Wiley | Journal of Cellular and Molecular Medicine
Based on 13 months of fieldwork which was conducted among middle-class families in Beijing, this article explores young children’s daily bodily practices and juxtaposes these practices with discourses on child-rearing which have gained prominence in post-Mao China. The article aims to demonstrate that the new discourse on childhood, education, and child-rearing, which has been promoted by the Chinese government since the 1980s, does not always correspond to, and sometimes even contradicts, actual ...
Tópico(s): China's Socioeconomic Reforms and Governance
2014 - SAGE Publishing | China Information
Lili Barad, Revital Schick, Naama Zeevi‐Levin, Joseph Itskovitz‐Eldor, Ofer Binah,
Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) have the capacity to differentiate into any specialized cell type, including cardiomyocytes. Therefore, hESC-derived and hiPSC-derived cardiomyocytes (hESC-CMs and hiPSC-CMs, respectively) offer great potential for cardiac regenerative medicine. Unlike some organs, the heart has a limited ability to regenerate, and dysfunction resulting from significant cardiomyocyte loss under pathophysiological conditions, such as ...
Tópico(s): Congenital heart defects research
2014 - Elsevier BV | Canadian Journal of Cardiology
Meital Ben-Ari, Revital Schick, Lili Barad, Atara Novak, Erez Ben-Ari, Avraham Lorber, Joseph Itskovitz‐Eldor, Michael R. Rosen, Amir Weissman, Ofer Binah,
We previously reported that induced pluripotent stem cell-derived cardiomyocytes manifest beat rate variability (BRV) resembling heart rate variability (HRV) in the human sinoatrial node. We now hypothesized the BRV-HRV continuum originates in pacemaker cells.
Tópico(s): EEG and Brain-Computer Interfaces
2014 - Elsevier BV | Heart Rhythm
... hand, the GKS nappes underlie those of the Binah meta-volcano sedimentary Complex (CB) which belongs to ...
Tópico(s): earthquake and tectonic studies
2013 - Scientific Research Publishing | International Journal of Geosciences
Yee-Ki Lee, Philip Wing‐Lok Ho, Revital Schick, Yee‐Man Lau, Wing‐Hon Lai, Ting Zhou, Yanhua Li, Kwong‐Man Ng, S.L. Ho, Miguel A. Esteban, Ofer Binah, Hung‐Fat Tse, Chung‐Wah Siu,
Tópico(s): DNA Repair Mechanisms
2013 - Springer Science+Business Media | Pflügers Archiv - European Journal of Physiology