Gabriel Miguel Gomes Guerreiro, Frank Martin, Thomas Dreyer, Guangya Yang, Björn Andresen,
The rapid expansion of wind power needs increased efforts in establishing rules for connecting wind power plants (WPPs) through grid codes and standards. This makes grid compliance testing and model validation more complex for wind turbine generator (WTG) manufacturers and WPP developers. This paper explores various challenges and solutions within the wind industry concerning grid compliance and the integration of large-scale WPPs. Traditionally, WTG original equipment manufacturers (OEMs) conduct ...
Tópico(s): HVDC Systems and Fault Protection
2024 - Institute of Electrical and Electronics Engineers | IEEE Access
Jad Othman, Manja Meggendorfer, Enrico Tiacci, Christian Thiede, Richard F. Schlenk, Richard Dillon, Sebastian Stasik, Alessandra Venanzi, Sarah Bertoli, Éric Delabesse, Pierre‐Yves Dumas, Arnaud Pigneux, Audrey Bidet, Amanda Gilkes, Ian Thomas, Maria Teresa Voso, Alessandro Rambaldi, Lorenzo Brunetti, Vincenzo Maria Perriello, Vibeke Andresen, Bjørn Tore Gjertsen, Maria Paola Martelli, Christian Récher, Christoph Röllig, Martin Bornhäuser, Hubert Serve, Carsten Müller‐Tidow, Claudia D. Baldus, T. Haferlach, Nigel H. Russell, Brunangelo Falini,
NPM 1-mutated acute myeloid leukemia (AML) shows unique features. However, the characteristics of "therapy-related" NPM1-mutated AML (t-NPM1 AML) are poorly understood. We compared the genetics, transcriptional profile, and clinical outcomes of t-NPM1 AML, de novo NPM1-mutated AML (dn-NPM1 AML), and therapy-related AML (t-AML) with wild-type NPM1 (t-AML). Normal karyotype was more frequent in t-NPM1 AML (n = 78/96, 88%) and dn-NPM1 (n = 1986/2394, 88%) than in t-AML (n = 103/390, 28%; P < .001). DNMT3A and TET2 were ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2022 - Elsevier BV | Blood
Vibeke Andresen, Bjørn Tore Gjertsen,
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the accumulation of immature myeloid progenitor cells in the bone marrow, compromising of normal blood cell production and ultimately resulting in bone marrow failure. With a 20% overall survival rate at 5 years and 50% in the 18- to 65-year-old age group, new medicines are needed. It is proposed that development of repurposed drugs may be a part of the new therapy needed. AML is subdivided into recurrent molecular entities ...
Tópico(s): Retinoids in leukemia and cellular processes
2017 - Frontiers Media | Frontiers in Medicine
Per Stenstad, Martin Andresen, Bjørn Steinar Tanem, Per Stenius,
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2007 - Springer Science+Business Media | Cellulose
Leszek Pająk, Anna Sowiżdżał, Paweł Gładysz, Barbara Tomaszewska, Maciej Miecznik, Trond Andresen, Bjørn Frengstad, Anna Chmielowska,
The paper describes application of the cross-impact method in the process of selecting locations and technologies used in a geothermal system based on energy accumulated in a dry rock formation, where CO2 is used as the working medium. The survey is based on the opinion of a group of 20 experts representing different fields of earth and technical sciences. They represent Norway and Poland, where the location of such a system is considered. Based on experts’ experience and opinions, all factors that ...
Tópico(s): Mining and Gasification Technologies
2021 - Multidisciplinary Digital Publishing Institute | Energies
Arman Fathollahi, Björn Andresen,
This paper introduces the Adaptive Coordinated Fixed-Time Synergetic Controller (ACFSC) designed for the Thyristor Controlled Series Capacitor (TCSC) and the generator excitation system. The primary objective is to enhance power system transient stability and voltage regulation performance particularly in scenarios involving unknown generator parameters. For the controller design of both generator excitation and TCSC, a linear combination of local parameters is employed to achieve the control objectives. ...
Tópico(s): Frequency Control in Power Systems
2024 - Institute of Electrical and Electronics Engineers | IEEE Access
Arman Fathollahi, Meysam Gheisarnejad, Björn Andresen, Hamed Farsizadeh, Mohammad Hassan Khooban,
The dc/dc full-bridge (FB) converters are often utilized as the interface system in telecom power applications. The constant power loads (CPLs) in the telecom power systems demonstrate negative impedance which threatens the stability of the dc/dc converters. To address this issue, in this brief, a nonlinear controller is designed for the stabilization of the dc/dc full-bridge converter feeding CPLs. The soft actor–critic (SAC) algorithm with deep neural networks is adopted based on deep reinforcement ...
Tópico(s): Real-time simulation and control systems
2023 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Circuits & Systems II Express Briefs
Meysam Gheisarnejad, Ghazal Mirzavand, Reza Rouhi Ardeshiri, Björn Andresen, Mohammad Hassan Khooban,
Electric vehicles (EVs) are expected to account for a significant percentage of the vehicle market in the coming years. The speed regulator is the inseparable part of EVs to solve challenges such as managing battery energy or adapting to road conditions. Since the operation of the EV system is time-variant due to parametric variations and road situations, the regulation of such systems is a complex task that cannot be effectively accomplished by the conventional deterministic control methodologies. ...
Tópico(s): Advanced Battery Technologies Research
2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Emerging Topics in Computational Intelligence
Jason MacDowell, Yingying Wang, Ryan Quint, Yongning Chi, Bernie Ernst, S. Saylors, David Jacobson, Björn Andresen, Poul Ejnar Sørensen, Raphael Portales, Dan Brake, Bob Zavadil, Luke Robinson,
Our electrical world is changing. The journey we are on today parallels the era of Edison, Tesla, and Westinghouse in the early race for electrification. Change abounds: energy from nature, inverter-based technology, smart and smarter grids; decentralized power, and intercontinental interconnection. This new age of energy offers new choices and challenges, all heavily influenced by the practices that evolved over the past century and institutionalized in standards, interconnection requirements, ...
Tópico(s): HVDC Systems and Fault Protection
2019 - Institute of Electrical and Electronics Engineers | IEEE Power and Energy Magazine
Mattias Rickhag, William A. Owens, Marie-Therese Winkler, Kristine Nørgaard Strandfelt, Mette Rathje, G. Sørensen, Bjørn Andresen, Kenneth L. Madsen, Trine N. Jørgensen, Gitta Wörtwein, David P.D. Woldbye, Harald H. Sitte, Lynette C. Daws, Ulrik Gether,
The dopamine transporter (DAT) is responsible for sequestration of extracellular dopamine (DA). The psychostimulant amphetamine (AMPH) is a DAT substrate, which is actively transported into the nerve terminal, eliciting vesicular depletion and reversal of DA transport via DAT. Here, we investigate the role of the DAT C terminus in AMPH-evoked DA efflux using cell-permeant dominant-negative peptides. A peptide, which corresponded to the last 24 C-terminal residues of DAT (TAT-C24 DAT) and thereby contained ...
Tópico(s): Neuroscience and Neuropharmacology Research
2013 - Elsevier BV | Journal of Biological Chemistry
Mattias Rickhag, Freja Herborg, G. Sørensen, Kristine Nørgaard Strandfelt, Bjørn Andresen, Kamil Gotfryd, Kenneth L. Madsen, Ib Vestergaard Klewe, Ina Ammendrup‐Johnsen, Jacob Eriksen, Amy Hauck Newman, Ernst‐Martin Füchtbauer, Jesús Gomeza, David P.D. Woldbye, Gitta Wörtwein, Ulrik Gether,
The dopamine transporter mediates reuptake of dopamine from the synaptic cleft. The cellular mechanisms controlling dopamine transporter levels in striatal nerve terminals remain poorly understood. The dopamine transporters contain a C-terminal PDZ (PSD-95/Discs-large/ZO-1) domain-binding sequence believed to bind synaptic scaffolding proteins, but its functional significance is uncertain. Here we demonstrate that two different dopamine transporter knock-in mice with disrupted PDZ-binding motifs ( ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2013 - Nature Portfolio | Nature Communications
Juan Carlos Ausin, Daniel Navarro Gevers, Björn Andresen,
Abstract The GAMESA voltage ride‐through capability test unit was designed as a tool for voltage dip studies for different wind turbine (WT) configurations and to investigate specific grid code requirements. By generating a voltage dip at the WT terminals, the WT manufacturer is able to check that the equipment works according to the design specifications, fulfils the grid code requirements and can validate the simulation models. This paper presents a description of the unit, the methodology used ...
Tópico(s): Power System Reliability and Maintenance
2007 - Wiley | Wind Energy
Meysam Gheisarnejad, Allahyar Akhbari, Mohsen Rahimi, Björn Andresen, Mohammad Hassan Khooban,
Due to the negative impedance potential of constant power loads (CPLs), the stability of power electronic converters-based electrical distribution networks is prone to instability. This brief proposes a robust control technique based on deep reinforcement learning to stabilize a DC microgrid (MG) with parallel boost converters when feeding CPLs. For this purpose, a model-free sliding mode controller (MFSMC) has been applied to the DC MG. The MFSMC controller does not need any identification of converters ...
Tópico(s): Smart Grid Energy Management
2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Circuits & Systems II Express Briefs
Arman Fathollahi, Björn Andresen,
Given the intricate nature of contemporary energy systems, addressing the control and stability analysis of these systems necessitates the consideration of highly large-scale models. Transient stability analysis stands as a crucial challenge in enhancing energy system efficiency. Power System Stabilizers (PSSs), integrated within excitation control for synchronous generators, offer a cost-effective means to bolster power systems’ stability and reliability. In this study, we propose an enhanced nonlinear ...
Tópico(s): Frequency Control in Power Systems
2023 - Multidisciplinary Digital Publishing Institute | Fractal and Fractional
Mahdi Mosayebi, Meysam Gheisarnejad, Hamed Farsizadeh, Björn Andresen, Mohammad Hassan Khooban,
Due to the increase in the number of electric vehicles (EVs) in the world, there is a need to design superior performance and lower operating costs of charging infrastructures to serve these vehicles. Merging extreme fast charging technology with the portable feature can provide a user-friendly and cost-effective structure for charging EVs. This brief proposes a Smart Extreme Fast Portable Charger (SEFPC) for Electric Vehicles which have several input ports (e.g., the power grid or Renewable Energy ...
Tópico(s): Wireless Power Transfer Systems
2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Circuits & Systems II Express Briefs
A. K. Thompson, Alf Terje Andresen, Bjørn Juliussen, Stephen Heath, Thomas E. Gundersen,
Tópico(s): Environmental Chemistry and Analysis
2012 - | CORROSION
Björn F. Andresen, Gorm Greisen, Simon Hyttel-Sørensen,
Tópico(s): Non-Invasive Vital Sign Monitoring
2020 - Springer Nature | Pediatric Research
Martina Giovannella, Björn F. Andresen, Julie Bjerglund Andersen, Sahla El Mahdaoui, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Gorm Greisen, Turgut Durduran, Udo M. Weigel, Ian Law,
Diffuse correlation spectroscopy (DCS) can non-invasively and continuously asses regional cerebral blood flow (rCBF) at the cot-side by measuring a blood flow index (BFI) in non-traditional units of cm 2 /s. We have validated DCS against positron emission tomography using 15 O-labeled water ( 15 O-water PET) in a piglet model allowing us to derive a conversion formula for BFI to rCBF in conventional units (ml/100g/min). Neonatal piglets were continuously monitored by the BabyLux device integrating DCS ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
2019 - SAGE Publishing | Journal of Cerebral Blood Flow & Metabolism
Björn F. Andresen, Agnese De Carli, Monica Fumagalli, Martina Giovannella, Turgut Durduran, Udo M. Weigel, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Gorm Greisen,
The BabyLux device is a prototype optical neuro-monitor of cerebral oxygenation and blood flow for neonatology integrating time-resolved reflectance spectroscopy and diffuse correlation spectroscopy.Here we report the variability of six consecutive 30 s measurements performed in 27 healthy term infants at rest. Poor data quality excluded four infants.Mean cerebral oxygenation was 59.6 ± 8.0%, with intra-subject standard deviation of 3.4%, that is, coefficient of variation (CV) of 5.7%. The inter-subject ...
Tópico(s): Hemodynamic Monitoring and Therapy
2019 - Springer Nature | Pediatric Research
Stefan Kleiser, Draženka Ostojić, Björn F. Andresen, Nassim Nasseri, Helene Isler, Felix Scholkmann, T Karen, Gorm Greisen, Martin Wolf,
Cerebral near-infrared spectroscopy (NIRS) oximetry may help clinicians to improve patient treatment.However, the application of NIRS oximeters is increasingly causing confusion to the users due to the inconsistency of tissue oxygen haemoglobin saturation (StO 2 ) readings provided by different oximeters.To establish a comparability of oximeters, in our study we performed simultaneous measurements on the liquid phantom mimicking properties of neonatal heads and compared the tested device to a reference ...
Tópico(s): Spaceflight effects on biology
2017 - Optica Publishing Group | Biomedical Optics Express
Stefan Kleiser, Nassim Nasseri, Björn F. Andresen, Gorm Greisen, Martin Wolf,
The SafeBoosC trial showed that cerebral oximetry combined with a treatment guideline can reduce the the burden of hypoxia in neonates by 50% [Brit. Med. J.350, g7635 (2015)]. However, guidelines based on oximetry by one oximeter are not directly usable by other oximeters. We made a blood-lipid phantom simulating the neonatal head to determine the relation between oxygenation values obtained by different oximeters. We calculated coefficients for easy conversion from one oximeter to the other. We additionally ...
Tópico(s): Neonatal Respiratory Health Research
2016 - Optica Publishing Group | Biomedical Optics Express
Gorm Greisen, Björn F. Andresen, Anne Mette Plomgaard, Simon Hyttel-Sørensen,
Preterm birth constitutes a major cause of death before 5 years of age and it is a major cause of neurodevelopmental impairment across the world. Preterm infants are most unstable during the transition between fetal and newborn life during the first days of life and most brain damage occurs in this period. The brain of the preterm infant is accessible for tissue oximetry by near-infrared spectroscopy. Cerebral oximetry has the potential to improve the long-term outcome by helping to tailor the support ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2016 - SPIE | Neurophotonics
Olav Smidsrød, Inger-lill Andresen, Hans Grasdalen, Bjørn Lársen, Terence Painter,
Tópico(s): Algal biology and biofuel production
1980 - Elsevier BV | Carbohydrate Research
Agnese De Carli, Björn F. Andresen, Martina Giovannella, Turgut Durduran, Davide Contini, Lorenzo Spinelli, Udo M. Weigel, Sofia Passera, Nicola Pesenti, Fabio Mosca, Alessandro Torricelli, Monica Fumagalli, Gorm Greisen,
Objectives A new device that combines, for the first time, two photonic technologies (time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy) was provided and tested within the BabyLux project. Aim was to validate the expected changes in cerebral oxygenation and blood flow. Methods A pulse oximeter and the BabyLux device were held in place (right hand/wrist and frontoparietal region, respectively) for 10 min after birth in healthy term infants delivered by elective caesarean ...
Tópico(s): Hemodynamic Monitoring and Therapy
2019 - BMJ | Archives of Disease in Childhood Fetal & Neonatal
Vladislav Akhmatov, Jørgen Nygaard Nielsen, Kim H. Jensen, Nikolaus Goldenbaum, Jan Thisted, Michael Frydensbjerg, Björn Andresen,
Transmission system operators and wind power plant developers must conduct power system stability analyses. Through such analyses they evaluate the fault-ride-through capability, control and grid-impact from wind power plants when the power system is subject to balanced, e.g. symmetrical three-phase, as well as unbalanced, e.g. asymmetrical two-phase-ground, phase-phase and single-phase-ground, short-circuit faults. Since the analyses are carried out utilizing large power system models, the representations ...
Tópico(s): Multilevel Inverters and Converters
2010 - SAGE Publishing | Wind Engineering
H. G. MUKHERJEE, Kok‐Ping Chan, Vibeke Andresen, Mariah L. Hanley, Bjørn Tore Gjertsen, Andrew G. Myers,
Nucleophosmin (NPM1) is a multifunctional phosphoprotein localized predominantly within the nucleoli of eukaryotic cells. Mutations within its C-terminal domain are frequently observed in patients with acute myeloid leukemia (AML), are thought to play a key role in the initiation of the disease, and result in aberrant, cytoplasmic localization of the mutant protein. We have previously shown that the electrophilic antiproliferative natural product (+)-avrainvillamide (1) binds to proteins, including nucleophosmin, ...
Tópico(s): Hemoglobinopathies and Related Disorders
2014 - American Chemical Society | ACS Chemical Biology
Martin Andresen, Leena‐Sisko Johansson, Bjørn Steinar Tanem, Per Stenius,
Tópico(s): Nanocomposite Films for Food Packaging
2006 - Springer Science+Business Media | Cellulose
Geir Andresen, Aud B. Eriksen, Bjørn Dalhus, Lise‐Lotte Gundersen, Frode Rise,
6-Substituted purin-2-ones have been prepared by completely regioselective addition of Grignard reagents to an N-protected purin-2-one followed by rearomatisation and deprotection. The target compounds may be regarded as analogues of the potent cytokinins trans-zeatin and benzylaminopurine (BAP), and most of the BAP analogues did induce increased weight growth in radish cotyledons. N-Protected (E)-6-styrylpurin-2-one underwent head to tail [2+2] dimerisation to the 1α,2α,3β,4β-substituted cyclobutane ...
Tópico(s): Fungal Plant Pathogen Control
2001 - Royal Society of Chemistry | Journal of the Chemical Society Perkin Transactions 1
Åse Lekang Sørensen, Bjørn Ludvigsen, Inger Andresen,
The number of EVs is increasing globally. In cold climates, it is generally recommended to use electricity from the grid to preheat the EV cabin before using the car, to extend driving ranges, to ensure comfort, and for safety. A majority of such preheating sessions are happening in the morning hours during the winter, when there is also a high demand for other energy use. It is thus important to understand the power loads for grid-connected preheating of EV cabins. This work presents an experimental ...
Tópico(s): Refrigeration and Air Conditioning Technologies
2023 - Elsevier BV | Applied Energy
Martin Bo Rasmussen, Vibeke R. Eriksen, Björn F. Andresen, Simon Hyttel-Sørensen, Gorm Greisen,
Tissue oxygenation estimated by near-infrared spectroscopy (NIRS) is a volume-weighted mean of the arterial and venous hemoglobin oxygenation. In vivo validation assumes a fixed arterial-to-venous volume-ratio (AV-ratio). Regulatory cerebro-vascular mechanisms may change the AV-ratio. We used hypotension to investigate the influence of blood volume distribution on cerebral NIRS in a newborn piglet model. Hypotension was induced gradually by inflating a balloon-catheter in the inferior vena cava and ...
Tópico(s): Hemodynamic Monitoring and Therapy
2017 - SPIE | Journal of Biomedical Optics