George Target, Anthony Hilton, Rosemary Righter, John Fryer, Jim Tucker, Colin Haycraft Chairman, Jon Swain, Alan Gibson, Jean Robertson Travel Editor, Martin Leighton, Berry Ritchie, Graham Rose, Eric Dehn Broadcaster, Nick Pitt, Julian Symons, Martyn Sutton, Margaret McCartney, Jason Tomas, Philip Oakes, Colin Simpson, Diana Winsor, Florence Aylmer, Henry Brandon, Stephen Games, Clarrie Grimmett, Richard Milner, Bernard Levin, Mark Ottaway, David Dougill, J. G. Ryene, Mitchell Platts, Joe Irving, Susannah Clapp, Neil Lyndon Guest writer, Jad Adams, L. J. Stallard Managing Director, Kingsley Amis, Derek Jewell, Denise Clark, Paul Addison, Peter Rodgers Energy Editor, Marina Warner, Adrianne Blue, Norman Harris, John Ballantine, Peter Ackroyd, Geoffrey Cannon, Brian Wilson, Peter Kellner, Robin Marlar, Robert Troop, Iqbal Athas, Hugh Somerville, Malcolm Crawford Economics Editor, Roger Eglin, Tana de Zulueta, Michael Bilton, Glenn Gale, Peter Lennon, Nick King, Brian Jackman, Judith Jackson, Richard Girling, Nicholas Carroll, Elizabeth Grice, John Hopkins, John Barnes, Mark Neil, Maj. General R. S. N. Mans, Geoffrey Young, Eric Marsden, Charles Medawar, Hugo Young Political Editor, Marina Adams, Malcolm Winton, Peter Stothard, Alan Ryan, Jeremy Brooks, Desmond Shawe-Taylor, Allson Miller, Betka Zamoyska, Alan Brien, Desmond Bluett, Russell Davies, Gwen Nuttall, John Bell, Roy Fuller, W. G. Bromley, Patrick Rowley, John Martin, Dilys Powell, F Savage, Clive Branson, John Bell City Editor, Russell Miller, Brough Scott, C. Skeffigton Quin, Milovan Djilas, Felix Aprahamian, Alex raymond, Jack Fingleton, David Leitch, Gitta Sereny, Tony Allaway, Ian Jack, Peter Clarke, Godfrey Smith, Peter Dear, Richard Burnell, Harold Evans, Andrew Stephen, Hunter Davies, Michael Dobbs, Brian Clarke, Brian Glanville, John Carey, Keith Richardson, Graham Searjeant, Andrew Lycett, Peter Dunn, Caroline Silver, Michael Roberts, James Fenton, Maureen Walker, Cleo Laine, Peter James, Elizabeth Dixon, Michael Jones Political Correspondent, Virginia Beardshaw, Marina Vaizey, Chris Lightbown, James Danziger, Phillip Knightley, John Worrall, Peter Wilby Education Correspondent, Philip Jacobson, Tony Money Latin Master, Roland Adburgham, Patience Wheatcroft, Roger Ratcliffe, Boris Schapiro,
... West bank spiral of provocation, revenge and bloodshed Suarez helps Bar on artist Greek puzzle How Iran ... Hampton & Sons International Village Hallsea Wells Ltd Costa Blanca Investments Ltd Sun Style… Sea Style Club Squash ...
1980 - Gale Group | Sunday Times HA GDA
Araceli Sánchez Jiménez, R.C. Puelles, Marta Pérez-Fernández, Paloma Gómez-Fernández, Leire Barruetabeña, Nicklas Raun Jacobsen, Blanca Suarez‐Merino, Christian Micheletti, Nicolas Manier, Bénédicte Trouiller, José M. Navas, Judit Kálmán, Beatrice Salieri, Roland Hischier, Yordan Handzhiyski, Margarita D. Apostolova, Niels Hadrup, Jacques Bouillard, Yohan Oudart, C. Merino, Erika Garcia, Biase Liguori, Stefania Sabella, Jérôme Rose, Armand Masion, Karen S. Galea, Sean Kelly, Sandra Štěpánková, Catherine Mouneyrac, Andrew Barrick, Amélie Châtel, Mária Dušinská, Elise Rundén‐Pran, Espen Mariussen, Christophe Bressot, Olivier Aguerre-Chariol, Neeraj Shandilya, Henk Goede, J. Gómez, Sophie Simar, Fabrice Nesslany, Keld Alstrup Jensen, Martie van Tongeren, Isabel Rodríguez Llopis,
The implementation of Safe(r) by Design (SbD) in industrial innovations requires an integrated approach where the human, environmental and economic impact of the SbD measures is evaluated across and throughout the nanomaterial (NM) life cycle. SbD was implemented in six industrial companies where SbD measures were applied to NMs, nano-enabled products (NEPs) and NM/NEP manufacturing processes. The approach considers human and environmental risks, functionality of the NM/NEP and costs as early as possible ...
Tópico(s): Chemical Safety and Risk Management
2020 - Elsevier BV | NanoImpact
Jacquey Visick, Saily Payne, Waldemar Januszczak, John Dugdale, Michael Prescott, J O'Brien, George Mitchell, Mikhail Gorbachev, Patrick French, Matthew Wall, Barbara Hall, Judith O'Reilly Education Correspondent, Humphrey Errington, John Smith, Steve Sailer, Andrew Warshaw, Jim Munro, Jon Swain, Philip Norman, I O'Brien, G Bayfield, Dan Pearson, John Peter, Patricia Clarke, Amanda Ursell, Mrs D Radglck, Elisabeth Hoodless Executive Director, John Jay, Michael Fleiding, Lucy lrvine, Gwyneth Paltrow, Betty Harding, Frank Whitford, Sheridan Morley, Ivo Tennant, Alistair Scott, Sally O'Reilly, Lucy Hughes-Hallett, David Smith, Mrs G Blddlecombe, John Goetz, Chris Dignan, Melanie Phillips, Nick Pitt, William Green, Neil Wormald, E P, Jane Bussmann, Andrew Sullivan, Stephen Grey, Vincent Kearney, Dylan Jones, Mary Wilson, K R, Marlin James, Simon Read, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, John Hegley, Eleanor Mills, Anthony Sattin, Steve Farrar, Robert Winnett, Susan d'ARCY, Jeremy Seal, Irwin Stelzer, B M, Tom English, Robert Hewison, Peter Wilson, Roger Anderson, David Dougill, E McDonald, John Evans, Philip Kingsley, Andrew Gardner, David Hewson, Tania Alexander, Chris Hastings, Harvey Porlock, Margaret Coles, Jonathon Carr-Brown, Alasdair Reid, Hugh Mcllvanney, Hugh Canning, Nigel Williams, Jeremy Clarkson, B T, David Nokes, Jan Newton, Peter Conradi, Louise Taylor, John Waples Deputy City Editor, Edward Porter, Stewart Lee, Mark Guthrie, Paul Eddy, Derek Lundy, Michael Jones, Sam Murphy, John le Carre, Graham Otway, S Davidson, Hugh McManners Defence Correspondent, Nick Gardner, Shelley von Strunckel, D V, Reggie Oliver, Quentin Letts, Peter Parker, Phillip Oppenheim, Josephine Smit, Tom Conran, Paul Donovan, Sue Lawrence, Le Grand Macabre, Hugh McIlvanney, D A Clark, Smita Talati, Salman Rushdie, Derek Clements, Paul Driver, Garth Pearce, Simon Fanshawe, John Follain, Maeve Sheehan, Nicholas Hellen, Steven Downes, Ian Hawkey, David Leppard, Martin Johnson, Alicia Wyllie, Mark Edwards, Steve Farrar Science Correspondent, Kirstie Hamilton, Adrienne Katz, Robert Runcie, Tom Shone, Susan Clark, David Lawrenson, Micheal Specter, East Cowes, Josh Salzamann, David Spurlock, Paul Ostendorf, Phil Baker, Karen Bayne, Jennifer Asiama, Raymond Keene, C L, Juliette Terzleff, Cosmo Landesman, Patrick Francis, Diana Wright, James Joyce, David Ginola, Helen Hawkins, Michael Prescott Political Editor, Paul Nuki Consumer Affairs Editor, Stephen Jones, Dave Burton, Nick Cain, Richard Evans, Stephen Bevan, Paul Nuki, Caroline Donald, Patrick Fussell, Thomas Sutcliffe, Martin Searby, Keith Wheatley, Claire Oldfield, Alun Roderick, David Walsh, Caroline Gascoigne, Zoé Linkson, Colin McDowell, Lois Rogers Medical Correspondent, Stephen Armstrong, Nick MacKinnon, Ann Wroe, Christopher Goodwin, Mark Macaskill, Mark Prigg, Nick Harvey, David Cains, Richard Woods, Garth Alexander, Maurice Chittenden, Sir Terence Conran, Richard Brooks Arts Editor, Andrew Lorenz Business Editor, Judith O'Reilly, Mark Franchetti, Jonathan Powell, Ray Hutton, Cllve Davis, Susan Elkin, Brian Murray, Matthew Parris, Tara Palmer-Tomkinson, Michael Sheridan, David Starkey, Simon Callow, John Harlow, Godfrey Smith, Bill Rogers, John Loaring, Matthew Lynn, Richard Davies, Kate Thornton, John Waples, John Thomson, A A Gill, Matthew Campbell, Brian Glanville, Gary Keenan, David Hutcheon, Tom Robbins, David Sumner Smith, Jonathon Carr-Brown Political Reporter, Robert Johnston, Chrissy Iley, Stephen Pettitt, Trushar Barot, Kevin Goldstein-Jackson, John Spurling, T L, Ian Hunter, Andrew Lorenz, F Stiames, Naomi Caine, Liam Clarke, Charile Dimmock, David Wickers, Sally Kinnes, Roger Dobson, Tom Rhodes, J P, Andrew Frankel, Nicholas Hellen Media Correspondent, Joe Lovejoy, Jonathan Futrell, Rupert Steiner, E C, Hugh Pearman, Dan Cairns, George Stephanopoulos, David Parsley, L Steach, John Phillips, J H, Delshad Karanjla, David Smith Economics Editor, K Evans, Penny Perrick, P G, Anthony Howard, Bob Dwyer, Joanna Simon, Clive Lucas, Chris Feetenby, Barry Newcombe, Nick Faldo, Dominic Rushe, Alan Ross, Boris Schapiro, Russ Guardian,
... 99pp342 The Chin Kiss King by Ana Veciana-Suarez Canongate £12.99 pp312 The Sunday Times Paperbacks ...
1999 - Gale Group | Sunday Times HA GDA
Anna Maria Giusti, Rambabu Atluri, Rositsa Tsekovska, Agnieszka Gajewicz, Margarita D. Apostolova, Chiara Laura Battistelli, Eric A.J. Bleeker, Cecilia Bossa, Jacques Bouillard, Mária Dušinská, Paloma Gómez-Fernández, Roland Grafström, Maciej Gromelski, Yordan Handzhiyski, Nicklas Raun Jacobsen, Paula Jantunen, Keld Alstrup Jensen, Agnieszka Mech, José M. Navas, Penny Nymark, Agnes G. Oomen, Tomasz Puzyn, Kirsten Rasmussen, Christian Riebeling, Isabel Rodríguez Llopis, Stefania Sabella, Juan Riego Sintes, Blanca Suarez‐Merino, Speranţa Tănăsescu, Håkan Wallin, Andrea Haase,
The physico-chemical properties of manufactured nanomaterials (NMs) can be fine-tuned to obtain different functionalities addressing the needs of specific industrial applications. The physico-chemical properties of NMs also drive their biological interactions. Accordingly, each NM requires an adequate physico-chemical characterization and potentially an extensive and time-consuming (eco)toxicological assessment, depending on regulatory requirements. Grouping and read-across approaches, which have ...
Tópico(s): Chemistry and Chemical Engineering
2019 - Elsevier BV | NanoImpact
Remy Franken, Minne B. Heringa, Thies Oosterwijk, Miikka Dal Maso, Wouter Fransman, Tomi Kanerva, Biase Liguori, Mikko Poikkimäki, Isabel Rodríguez Llopis, Arto Säämänen, Helene Stockmann‐Juvala, Blanca Suarez‐Merino, Keld Alstrup Jensen, Rob Stierum,
The current work describes the interaction with various stakeholder groups to establish consensus on stage-gate specific criteria that human risk assessment (HRA) models for manufactured nanomaterials (MN) need to comply with. During the decisive steps in the innovation process, which can be described in a simplified way as stage-gates, it is decided that an innovation makes it either to launch, or is cancelled during one of these stages. However, at present, it is unknown which current HRA models ...
Tópico(s): Sustainable Supply Chain Management
2019 - Elsevier BV | NanoImpact
Lya G. Soeteman‐Hernández, Margarita D. Apostolova, Cindy Bekker, Susan Dekkers, Roland Grafström, Monique Groenewold, Yordan Handzhiyski, Petra Herbeck‐Engel, Karl Hoehener, V. Karagkiozaki, Sean Kelly, Annette Kraegeloh, S. Logothetidis, Christian Micheletti, Penny Nymark, Agnes G. Oomen, Thies Oosterwijk, Isabel Rodríguez Llopis, Stefania Sabella, Araceli Sánchez Jiménez, Adriënne J.A.M. Sips, Blanca Suarez Merino, Isabella Tavernaro, Jacqueline van Engelen, S. Wijnhoven, C.W. Noorlander,
Nanotechnologies are characterized by a growing legacy of already marketed and novel manufactured nanomaterials (MNMs) and nano-enabled products with a lack of a coherent risk governance system to address their safety effectively. In response to this situation, a proactive system is needed to minimize the gap between the pace of innovation and the pace of developing nano-specific risk governance. With the Safe Innovation Approach (SIA), we seek to enhance the ability of all stakeholders to address ...
Tópico(s): Chemistry and Chemical Engineering
2019 - Elsevier BV | Materials Today Communications
Annette Kraegeloh, Blanca Suarez‐Merino, Teun Sluijters, Christian Micheletti,
Manufactured nanomaterials (MNMs) are regarded as key components of innovations in various fields with high potential impact (e.g., energy generation and storage, electronics, photonics, diagnostics, theranostics, or drug delivery agents). Widespread use of MNMs raises concerns about their safety for humans and the environment, possibly limiting the impact of the nanotechnology-based innovation. The development of safe MNMs and nanoproducts has to result in a safe as well as functional material or ...
Tópico(s): Chemistry and Chemical Engineering
2018 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Alazne Domínguez, Blanca Suarez‐Merino, Felipe Goñi‐de‐Cerio,
Major central nervous system disorders represent a significant and worldwide public health problem. In fact, the therapeutic success of many pharmaceuticals developed to treat central nervous system diseases is still moderate, since the blood-brain barrier (BBB) limits the access of systemically administered compounds to the brain. Therefore, they require the application of a large total dose of a drug, and cause numerous toxic effects. The development of nanotechnological systems are useful tools ...
Tópico(s): Graphene and Nanomaterials Applications
2014 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology
Hazel Lin, Tina Buerki‐Thurnherr, Jasreen Kaur, Peter Wick, Marco Pelin, Aurelia Tubaro, Fabio Candotto Carniel, Mauro Tretiach, Emmanuel Flahaut, Daniel Iglesias, Ester Vázquez, Giada Cellot, Laura Ballerini, Valentina Castagnola, Fabio Benfenati, Andrea Armirotti, Antoine Sallustrau, Frédéric Taran, Mathilde Keck, Cyrill Bussy, Sandra Vranic, Kostas Kostarelos, Mona Connolly, José M. Navas, Florence Mouchet, Laury Gauthier, James E. Baker, Blanca Suárez-Merino, Tomi Kanerva, Maurizio Prato, Bengt Fadeel, Alberto Bianco,
Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the specific and versatile properties of these materials. However, the increasing production and use of 2D materials necessitate a thorough evaluation of the potential impact on human health and the environment. Furthermore, harmonized test protocols are needed with which to assess the safety of 2D materials. The Graphene Flagship project (2013-2023), funded ...
Tópico(s): Carbon and Quantum Dots Applications
2024 - American Chemical Society | ACS Nano
Verónica I. Dumit, Ammar Ammar, Martine Bakker, Miguel Á. Bañares, Cecilia Bossa, Anna Luisa Costa, Hilary Cowie, Damjana Drobne, Thomas E. Exner, Lucian Farcal, Steffi Friedrichs, Irini Furxhi, Roland Grafström, Andrea Haase, Martin Himly, Nina Jeliazkova, Iseult Lynch, Dieter Maier, C.W. Noorlander, Hyun Kil Shin, Galo J. A. A. Soler‐Illia, Blanca Suarez‐Merino, Egon Willighagen, Penny Nymark,
Developing safe and sustainable nanomaterials-based solutions to current global challenges including clean energy, sustainable food production and water security requires access to high quality data and appropriate analysis and modelling approaches. Achieving these challenges requires increased re-use of research data to accelerate progress and support development of new materials that are safe and sustainable for energy capture and storage, nano-agriculture and environmental remediation. The principles ...
Tópico(s): Data Quality and Management
2023 - Elsevier BV | Nano Today
Kirsi Siivola, Michael J. Burgum, Blanca Suarez‐Merino, Martin J. D. Clift, Shareen H. Doak, Julia Catalán,
Abstract The number of publications in the field of nanogenotoxicology and the amount of genotoxicity data on nanomaterials (NMs) in several databases generated by European Union (EU) funded projects have increased during the last decade. In parallel, large research efforts have contributed to both our understanding of key physico-chemical (PC) parameters regarding NM characterization as well as the limitations of toxicological assays originally designed for soluble chemicals. Hence, it is becoming ...
Tópico(s): Air Quality and Health Impacts
2022 - BioMed Central | Particle and Fibre Toxicology
Araceli Sánchez Jiménez, R.C. Puelles, Marta Pérez-Fernández, Leire Barruetabeña, Nicklas Raun Jacobsen, Blanca Suarez‐Merino, Christian Micheletti, Nicolas Manier, Beatrice Salieri, Roland Hischier, Rositsa Tsekovska, Yordan Handzhiyski, Jacques Bouillard, Yohan Oudart, Karen S. Galea, Sean Kelly, Neeraj Shandilya, Henk Goede, J. Gómez, Keld Alstrup Jensen, Martie van Tongeren, Margarita D. Apostolova, Isabel Rodríguez Llopis,
Expectations for safer and sustainable chemicals and products are growing to comply with the United Nations and European strategies for sustainability. The application of Safe(r) by Design (SbD) in nanotechnology implies an iterative process where functionality, human health and safety, environmental and economic impact and cost are assessed and balanced as early as possible in the innovation process and updated at each step. The EU H2020 NanoReg2 project was the first European project to implement ...
Tópico(s): Nanotechnology research and applications
2022 - Elsevier BV | NanoImpact
Beatrice Salieri, Leire Barruetabeña, Isabel Rodríguez Llopis, Nicklas Raun Jacobsen, Nicolas Manier, Bénédicte Trouiller, Valentin Chapon, Niels Hadrup, Araceli Sánchez Jiménez, Christian Micheletti, Blanca Suarez Merino, Jean-Marc Brignon, Jacques Bouillard, Roland Hischier,
Moving towards safe and sustainable innovations is an international policy ambition. In the on-hand manuscript, a concept combining safe by design and sustainability was implemented through the integration of human and environmental risk assessment, life cycle assessment as well as an assessment of the economic viability. The result is a nested and iterative process in form of a decision tree that integrates these three elements in order to achieve sustainable, safe and competitive materials, products ...
Tópico(s): Sustainable Supply Chain Management
2021 - Elsevier BV | NanoImpact
Rubén L. Rodríguez-Expósito, Nathália Nocchi, María Reyes‐Batlle, Inés Sifaoui, Blanca Suárez‐Gómez, Ana R. Dı́az-Marrero, Marı́a L. Souto, José E. Piñero, José J. Fernández, Jacob Lorenzo‐Morales,
Opportunistic parasitic protozoa of genus Acanthamoeba are responsible to cause severe infections in humans such as Acanthamoeba Keratitis or Amoebic Granulomatous Encephalitis. Current treatments are usually toxic and inefficient and there is a need to access new therapeutic agents. The antiamoebic effects of nephthediol (1) and fourteen germacranolide and eudesmanolide sesquiterpene lactones (2-5, 7-12) isolated from the indigenous zoanthid Palythoa aff. clavata collected at the coast of Lanzarote, ...
Tópico(s): Plant Toxicity and Pharmacological Properties
2021 - Elsevier BV | Bioorganic Chemistry
Produção Nacional
Revisado por pares
Andrew Collins, Balasubramanyam Annangi, Laura Rubio, Ricard Marcos, Marco Dorn, Carolin Merker, Irina Estrela‐Lopis, Mihaela Roxana Cimpan, Mohamed Yousif Ibrahim, Emil Cimpan, Melanie Ostermann, Alexander Sauter, Naouale El Yamani, Sergey Shaposhnikov, Sylvie Chevillard, Vincent Paget, Romain Grall, Jozo Delić, Felipe Goñi‐de‐Cerio, Blanca Suarez‐Merino, Valérie Fessard, Kevin Hogeveen, Lise Maria Fjellsbø, Elise Rundén‐Pran, Táňa Brzicová, Jan Topinka, Maria João Silva, Paulo Emílio Corrêa Leite, Ana R. Ribeiro, José Mauro Granjeiro, Roland Grafström, Adriele Prina‐Mello, Mária Dušinská,
With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and reliable ways of testing NM safety-preferably using in vitro approaches, to avoid the ethical dilemmas associated with animal research. Data are needed for developing intelligent testing strategies for risk assessment of NMs, based on grouping and read-across approaches. The adoption of high throughput screening (HTS) and high content analysis (HCA) for NM toxicity testing allows the testing of numerous materials ...
Tópico(s): Nanotechnology research and applications
2016 - Wiley | Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
Felipe Goñi‐de‐Cerio, Julie Thévenot, Hugo Oliveira, Encarnación Pérez-Andrés, Edurne Berra, Marc Masa, Blanca Suarez‐Merino, Sébastien Lecommandoux, Pedro Heredia,
Encapsulating chemotherapy drugs in targeted nanodelivery systems is one of the most promising approaches to tackle cancer disease, avoiding side effects of common treatment. In the last decade, several nanocarriers with different nature have been tested, but polypeptide-based copolymers have attracted considerable attention for their biocompatibility, controlled and slow biodegradability as well as their low toxicity. In this work, we synthesized, characterized and evaluated poly(trimethylene carbonate)- ...
Tópico(s): Cancer Treatment and Pharmacology
2015 - American Scientific Publishers | Journal of Biomedical Nanotechnology
Amaia García‐Bilbao, Rubén Armañanzas, Z. Ispizua, Begoña Calvo, Ana Alonso‐Varona, Iñaki Inza, Pedro Larrañaga, Guillermo López-Vivanco, Blanca Suarez‐Merino, M. Betanzos,
Abstract Background Malignancies arising in the large bowel cause the second largest number of deaths from cancer in the Western World. Despite progresses made during the last decades, colorectal cancer remains one of the most frequent and deadly neoplasias in the western countries. Methods A genomic study of human colorectal cancer has been carried out on a total of 31 tumoral samples, corresponding to different stages of the disease, and 33 non-tumoral samples. The study was carried out by hybridisation ...
Tópico(s): Colorectal Cancer Treatments and Studies
2012 - BioMed Central | BMC Cancer
Katherine Karakoula, Blanca Suarez‐Merino, Samantha Ward, Kim Phipps, William Harkness, Richard D. Hayward, Dominic Thompson, Thomas S. Jacques, Brian Harding, John C. Beck, D. G. T. Thomas, Tracy Warr,
Abstract Loss of chromosome 22 and gain of 1q are the most frequent genomic aberrations in ependymomas, indicating that genes mapping to these regions are critical in their pathogenesis. Using real‐time quantitative PCR, we measured relative copy numbers of 10 genes mapping to 22q12.3‐q13.33 and 10 genes at 1q21‐32 in a series of 47 pediatric intracranial ependymomas. Loss of one or more of the genes on 22 was detected in 81% of cases, with RAC2 and C22ORF2 at 22q12‐q13.1 being deleted most frequently ...
Tópico(s): Cancer Genomics and Diagnostics
2008 - Wiley | Genes Chromosomes and Cancer
Tiziana Piepoli, Cemile Jakupoglu, Wenli Gu, Elena Lualdi, Blanca Suarez‐Merino, Pietro Luigi Poliani, Maria Grazia Cattaneo, Barbara Ortino, Dorota Goplen, Jian Wang, Rosa Mola, Francesca Inverardi, Carolina Frassoni, Rolf Bjerkvig, Ortrud K. Steinlein, L. Vicentini, Oliver Brüstle, Gaetano Finocchiaro,
Disruptions of LGI1 in glioblastoma (GBM) cell lines and LGI1 mutations in families with autosomal dominant epilepsy imply a role for LGI1 in glial cells as well as in neurons. Although we and others could not find LGI1 mutations in malignant gliomas, our initial studies appeared to support the idea that LGI1 is poorly expressed or absent in these tumors. Microarray data suggested that LGI1 could be involved in the control of matrix metalloproteinases, and we found that tumors derived from U87 glioblastoma ...
Tópico(s): Hedgehog Signaling Pathway Studies
2006 - Oxford University Press | Neuro-Oncology
Serena Pellegatta, Pietro Luigi Poliani, Daniela Corno, Francesca Menghi, Francesco Ghielmetti, Blanca Suarez‐Merino, Valentina Caldera, Sara Nava, Maria Ravanini, Fabio Facchetti, Maria Grazia Bruzzone, Gaetano Finocchiaro,
Abstract Cancer stem–like cells (CSC) could be a novel target for cancer therapy, including dendritic cell (DC) immunotherapy. To address this, we developed experiments aimed at DC targeting of neurospheres (NS) from GL261 glioma cells because neurospheres can be enriched in CSC. We obtained murine neurospheres by growing GL261 cells in epidermal growth factor/basic fibroblast growth factor without serum. GL261-NS recapitulated important features of glioblastoma CSC and expressed higher levels of radial ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2006 - American Association for Cancer Research | Cancer Research
Blanca Suárez‐Gómez, Marı́a L. Souto, Patricia G. Cruz, José J. Fernández, Manuel Norte,
The toxic profile of dinoflagellates varies even among identical species, raising an interesting question about the mechanism of toxin regulation and production. In consequence, it also poses a considerable problem in their control methods. In this paper, we report on the isolation and structural elucidation of several new ester derivatives of okadaic acid (OA) from artificial cultures of the genus Prorocentrum. These new compounds enlarge the range of target molecules that must be considered in ...
Tópico(s): Animal Ecology and Behavior Studies
2005 - American Chemical Society | Journal of Natural Products
Blanca Suarez‐Merino, Michael Hubank, Tamás Révész, William Harkness, Richard D. Hayward, Dominic Thompson, John L. Darling, D. G. T. Thomas, Tracy Warr,
Ependymomas are glial cell-derived tumors characterized by varying degrees of chromosomal abnormalities and variability in clinical behavior. Cytogenetic analy-sis of pediatric ependymoma has failed to identify consistent patterns of abnormalities, with the exception of monosomy of 22 or structural abnormalities of 22q. In this study, a total of 19 pediatric ependymoma samples were used in a series of expression profiling, quantitative real-time PCR (Q-PCR), and loss of heterozygosity experiments ...
Tópico(s): Sarcoma Diagnosis and Treatment
2005 - Oxford University Press | Neuro-Oncology
Antonio Hernández Daranas, José J. Fernández, Manuel Norte, José A. Gavín, Blanca Suárez‐Gómez, Marı́a L. Souto,
Abstract Marine toxins have drawn wide interest because their economical impact and disastrous effect upon the shellfish industry and public health in many parts of the world. One of the most interesting group of substances of marine toxins, from structural and pharmacological points of view are polyether compounds, which generally present a great diversity in size and potent biological activities. The subject of this work was about to biosynthesis of okadaic acid skeleton as leader as DSP toxins. ...
Tópico(s): Microbial Community Ecology and Physiology
2004 - Wiley | The Chemical Record
José J. Fernández, Blanca Suárez‐Gómez, Marı́a L. Souto, Manuel Norte,
The dinoflagellate Prorocentrum lima produces toxins involved in the red tide phenomenon known as diarrhetic shellfish poisoning (DSP). This paper reports the isolation and spectroscopic structural elucidation of new compounds related to DSP toxins, isolated from a laboratory culture of strain PLV2. Their structures were established from their spectroscopic data.
Tópico(s): Redox biology and oxidative stress
2003 - American Chemical Society | Journal of Natural Products
Barry A. Chioza, Abena Osei‐Lah, Lina Nashef, Blanca Suarez‐Merino, Hazel Wilkie, Pak C. Sham, Jo Knight, Philip Asherson, Andrew Makoff,
Idiopathic generalised epilepsy (IGE) is a common form of epilepsy, including several defined and overlapping syndromes, and likely to be due to the combined actions of mutations in several genes. In a recent study we investigated the calcium channel gene CACNA1A for involvement in IGE, unselected for syndrome, by means of association studies using several polymorphisms within the gene. We reported a highly significant case/control association with a silent single nucleotide polymorphism (SNP) in ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2002 - Springer Nature | European Journal of Human Genetics
Blanca Suárez‐Gómez, Marı́a L. Souto, Manuel Norte, José J. Fernández,
Diarrhetic shellfish poisoning is an illness caused by toxins accumulated in shellfish and produced by dinoflagellates, mainly of the Dinophysis and Prorocentrum genera. This paper reports the isolation and spectroscopic structural elucidation of a new compound, DTX-6 (2), an ester derivative of okadaic acid (OA) (1), isolated from an artificial culture of strain PLV2 of Prorocentrum lima.
Tópico(s): Redox biology and oxidative stress
2001 - American Chemical Society | Journal of Natural Products
Blanca Suarez‐Merino, Jacqueline M. Bye, Jennifer McDowall, M. T. Ross, Ian Craig,
Mutations at the Norrie disease gene locus, NDP, manifest in a broad range of defects. These range from a relatively mild, late-onset, exudative vitreoretinopathy to congenital blindness and sensorineural deafness combined, in some cases, with mental retardation. In addition, extensive deletions involving the NDP locus, located at Xp11.3, the adjacent monoamine oxidadase genes MAOA and MAOB, and additional material, result in a more severe pattern of symptoms. The phenotypes include all or some ...
Tópico(s): Metalloenzymes and iron-sulfur proteins
2001 - Wiley | Human Mutation
Carlos J. Bethencourt-Estrella, Nathália Nocchi, Atteneri López‐Arencibia, Desirée San Nicolás-Hernández, Marı́a L. Souto, Blanca Suárez‐Gómez, Ana R. Dı́az-Marrero, José J. Fernández, Jacob Lorenzo‐Morales, José E. Piñero,
Leishmaniasis and Chagas disease are neglected tropical diseases that cause problems in developing countries. The causative agents, Leishmania spp. and Trypanosoma cruzi, produce a clinical picture that can be fatal for the patient, such as Chagas heart disease, visceral leishmaniasis and megacolon, among others. Current treatments for these diseases are not very effective and highly toxic, since they require very prolonged treatments. The development of innovative, effective and safe drugs to fight ...
Tópico(s): Insect Pest Control Strategies
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Marian Crowley‐Henry, Edward O’Connor, Blanca Suarez-Bilbao,
Purpose This micro-level study unpacks the recruitment and retention of international professionals to small and medium-sized enterprises (SMEs). The study highlights the influence of the founders' international experience when applying organisational-level (meso) policies and practices. With their insider experience as skilled migrants, we share how the founders in each of the SMEs mobilised career capital into human resource management (HRM) strategies. Design/methodology/approach Combining literature ...
Tópico(s): Migration, Ethnicity, and Economy
2021 - Emerald Publishing Limited | Journal of Global Mobility The Home of Expatriate Management Research
Narjis Fikri‐Benbrahim, Fernando Martínez‐Martínez, Loreto Sáez‐Benito, Blanca Suárez Luque, José Pedro García Corpas, Joanna C. Moullin, Daniel Sabater‐Hernández,
The aim of this study was to assess the performance and feasibility of a protocol for screening type 2 diabetes in community pharmacy. Performance was primarily assessed by measuring stakeholders' adherence (pharmacists, patients and physicians) to the protocol's components.
Tópico(s): Diabetes Treatment and Management
2015 - Elsevier BV | Diabetes Research and Clinical Practice