Miao Luo, Jinfeng He, Yin Liang, Ping Zhan, Zhongqiu Zhao, Hui Xiong, Zhinan Mei,
Borneol is a long-established traditional Chinese medicine that has been found to be effective in treating pain and itchy skin. However, whether borneol has a therapeutic effect on chronic itch and ... remain unclear. To investigate the antipruritic effect of borneol and its molecular mechanism. DrugBAN framework and molecular docking were applied to predict the targets of borneol, and the calcium imaging or patch-clamp recording analysis were used to detect the effects of borneol on TRPA1, TRPM8 or TRPV3 channels in HEK293T ...
Tópico(s): Allergic Rhinitis and Sensitization
2023 - Elsevier BV | Journal of Ethnopharmacology
Rong Ma, Danni Lu, Jian Wang, Qian Xie, Jialiang Guo,
... differently to their target receptor. The Chinese medicine borneol ('Bing Pian' in Chinese) is a bicyclic monoterpenoid ... biological activities. Three kinds of Chinese medicines comprising borneol are used clinically, namely, L-Borneolum ('Ai Pian' ... Tian Ran Bing Pian' in Chinese), and synthetic borneol ('He Cheng Bing Pian' in Chinese). The three kinds of borneol have different stereochemical configurations, but their clinical uses ... basis for the selection of these kinds of borneol in clinical applications.The purpose of this study ...
Tópico(s): Natural product bioactivities and synthesis
2023 - Elsevier BV | Biomedicine & Pharmacotherapy
Nutdanai Lertsuphotvanit, Wichai Santimaleeworagun, Worrakanya Narakornwit, Tiraniti Chuenbarn, Jongjan Mahadlek, Takron Chantadee, Thawatchai Phaechamud,
Given its safety and apparent low aqueous solubility, borneol may serve as a matrix forming component of ... pocket targeting. Drug-free and vancomycin hydrochloride-loaded borneol ISMs were evaluated for pH, density, viscosity, contact ... and antimicrobial activities. Density and pH values of borneol-based ISMs decreased with increasing borneol concentration. Given their markedly low viscosity could facilitate ... of the drug-free and vancomycin HCl-loaded borneol ISMs increased after being in contact with the ...
Tópico(s): Advanced Drug Delivery Systems
2022 - Elsevier BV | International Journal of Pharmaceutics
Jinxiu Li, Jianmei Yuan, Yong Li, Jian Wang, Qian Xie, Rong Ma, Jiajun Wang, Mihong Ren, Danni Lu, Zhuo Xu,
d-Borneol has been widely used as a drug absorption enhancer, but there are few studies on the anti-resistance ability of d-borneol combined with cisplatin in cisplatin-resistant non-small ... the molecular mechanisms and sensitizing effects of d-borneol combined with cisplatin to against drug cisplatin resistance ... EMT markers, autophagy, and ferroptosis signaling pathways.d-Borneol in combination with cisplatin reduced tumor volume and ... differentially expressed genes were enriched in ferroptosis. d-Borneol in combination with cisplatin promoted ROS accumulation, increased ...
Tópico(s): Drug Transport and Resistance Mechanisms
2022 - Elsevier BV | Phytomedicine
Fangping Li, Shilin Huang, Mei Yu, Bingqi Wu, Zhuangwei Hou, Penglin Zhan, Zhihao Hou, Wenjie Huang, Junliang Zhao, Jihua Wang,
D-Borneol is a precious monoterpenoid widely used in the pharmaceutical and cosmetic industries. Cinnamomum burmannii (Nees et T. ... is one of the key resources for D-Borneol. However, only one chemotype of C. burmannii contain high content of D-Borneol in its leaves and stems. Limited by little information from C. burmannii, the D-Borneol biosynthesis mechanisms, as well as the mechanisms underlying the D-Borneol production differences among chemotypes remains elusive. To fill ... generated a completed genome of a high D-Borneol content chemotype of C. burmannii. Phylogenetic analysis suggests ...
Tópico(s): Phytochemical compounds biological activities
2022 - Elsevier BV | Industrial Crops and Products
Hanze Chen, Xinxin Xu, Qiwen Tang, Linhui Ni, Shuxia Cao, Yonggang Hao, Li Wang, Xingyue Hu,
... this study is to evaluate the effect of (+)-borneol, an antioxidant, on NETosis. Methods: Human neutrophils were ... to induce NETosis in vitro . Neutrophils treated with (+)-borneol at three different time points (−30 min, 0, ... stimulation were used to examine the effect of (+)-borneol on the formation of NETs. The ROS generation ... the potential mechanism of the inhibitory effect of (+)-borneol on NETosis. Results: (+)-Borneol pretreatment inhibited NETosis induced by PMA. Immunofluorescence staining visualized and confirmed the inhibitory effect. (+)-Borneol inhibited the burst of ROS in neutrophils caused ...
Tópico(s): Blood disorders and treatments
2022 - Frontiers Media | Frontiers in Pharmacology
Jui-Feng Lin, Yen-Shuo Liu, Yu‐Chuen Huang, Chih‐Wen Chi, Cheng-Chia Tsai, Tung‐Hu Tsai, Yu-Jen Chen,
... cancer. Bioactive constituents of medicinal herbs, such as borneol and tetrandrine, potentially improve drug penetration through the BBB and BTB. We hypothesized that borneol and tetrandrine might modulate the BBB and BTB ... were developed to explore the modulatory effects of borneol and tetrandrine on 5-FU penetration through the ... evaluate tumor growth. The experimental results demonstrated that borneol and borneol + tetrandrine reduced BBB integrity. The efflux pump function ... P-gp was partially inhibited by tetrandrine and borneol + tetrandrine. In the in vivo experiment, borneol + tetrandrine ...
Tópico(s): Barrier Structure and Function Studies
2022 - SAGE Publishing | Integrative Cancer Therapies
Yue Wu, Tingting Zhang, Xianqiang Li, Yimei Wei, Xinyu Li, Sixue Wang, Jun Liu, Dan Li, Shujun Wang, Tiantian Ye,
... the brain. Methods: We investigated the effect of borneol on meningeal lymphatic clearance of macromolecules with different ... the brain. To further investigate the mechanism of borneol regulating meningeal lymphatic drainage, immunofluorescence staining, western blotting, ... used. The cognitive function of AD mice after borneol treatment was evaluated using two behavioral tests: open ... water maze (MWM). Results: This study discovered that borneol could accelerate the lymphatic clearance of Aβ from ... meningeal lymphatic drainage. Preliminary mechanism analysis revealed that borneol could improve the permeability and inner diameter of ...
Tópico(s): Traumatic Brain Injury Research
2022 - Ivyspring International Publisher | Theranostics
Jinxiu Li, Jianmei Yuan, Yong Li, Jian Wang, Daoyin Gong, Qian Xie, Rong Ma, Jiajun Wang, Mihong Ren, Danni Lu, Zhuo Xu,
... appearance of drug resistance greatly hinders its efficacy. Borneol may promote drug absorption; however, synergism between borneol and CDDP in suppressing NSCLC is not clearly understood. Hence, we investigated borneol as a novel chemosensitizer to support chemotherapeutic efficacy ... effects.We compared viability after exposure to d-borneol, l-borneol, and synthetic borneol in two NSCLC cell lines, A549 and H460, ... most sensitive cells. We then assessed synergy between borneol forms and CDDP in cisplatin-resistant NSCLC cells, ...
Tópico(s): Metal complexes synthesis and properties
2022 - BioMed Central | Cellular & Molecular Biology Letters
Rong Ma, Qian Xie, Hongyan Li, Xiaoqing Guo, Jian Wang, Yong Li, Mihong Ren, Daoyin Gong, Tian Gao,
... in the prevention or treatment of stroke. l -borneol, a traditional Chinese medicine, has been used in ... new neurons. Here, our research shows that l -borneol can significantly improve the neurological deficits of pMCAO ... the same results. Immunohistochemistry also showed that l- borneol can increase the number of CD34 positive cells, further verifying that l- borneol can play a neuroprotective effect by promoting angiogenesis after cerebral ischemia injury. In addition, l- borneol can significantly promote the expression level of VEGF, ...
Tópico(s): Natural Compounds in Disease Treatment
2021 - Frontiers Media | Frontiers in Pharmacology
Yong Li, Mihong Ren, Jiajun Wang, Rong Ma, Hai Chen, Qian Xie, Hongyan Li, Jinxiu Li, Jian Wang,
Background: Borneol is a terpene and bicyclic organic compound that can be extracted from plants or chemically synthesized. As ... aimed to systematically examine the neuroprotective effects of borneol in the cascade reaction of experimental ischemic stroke ... and cell-based research on the actions of borneol against ischemic stroke in the past 20°years ... the neuroprotective effects and mechanism of action of borneol at different stages of cerebral ischemia. Results: Borneol is effective in the prevention and treatment of ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2021 - Frontiers Media | Frontiers in Pharmacology
Rui Ma, Ping Su, Qing Ma, Juan Guo, Suiqing Chen, Baolong Jin, Haiyan Zhang, Jinfu Tang, Tao Zhou, Chenghong Xiao, Guanghong Cui, Luqi Huang,
Borneol is a precious monoterpenoid with two chiral structures, (-)-borneol and (+)-borneol. Bornyl diphosphate synthase is the key enzyme in the borneol biosynthesis pathway. Many (+)-bornyl diphosphate synthases have been ... been identified. Blumea balsamifera leaves are rich in borneol, almost all of which is (-)-borneol. In this study, we identified a high-efficiency (-)- ... to (-)-bornyl diphosphate, which is then converted to (-)-borneol after dephosphorylation in vitro. BbTPS3 exhibited a Km ... strategies were applied to obtain a high-yielding (-)-borneol producing yeast strain. A codon-optimized BbTPS3 protein ...
Tópico(s): Microbial Natural Products and Biosynthesis
2021 - Elsevier BV | Synthetic and Systems Biotechnology
Qiuyan Zhu, San Tang, Xiaoqian Yang, Huang Ding, Xiaodan Liu, Xin-Bing Zeng, Huang Xiao-ping, Chang-Qing Deng,
... Previous studies have confirmed that the combination of borneol with other agents could promote the penetration of ... through the BBB. However, it remains unclear whether borneol can promote entry of the active components of ... to investigate the effects of a combination of borneol with AST IV and PNS against I/R injury and explore the mechanisms of borneol-promoting penetration of drug components into the BBB ... I/R injury was established, and drugs, including borneol, AST IV, and PNS, as well as their ...
Tópico(s): Drug Transport and Resistance Mechanisms
2021 - Elsevier BV | Phytomedicine
Qian Xie, Jinxiu Li, Taiwei Dong, Jianmei Yuan, Danni Lu, Rong Ma, Hongyan Li, Yong Li, Mihong Ren, Hai Chen, Jian Wang,
Abstract Objectives Natural borneol and synthetic borneol were commonly used to treat ischaemic stroke in clinical practice. This study evaluated their different neuroprotective effects on the remodelling and repair ... ischaemia. Methods We evaluated the different effects of borneol through neurological test and staining methods in cerebral ... were used to evaluate the reparative effects of borneol on NVU. Key findings The prevention and treatment of borneol could prolong recovery time, reduce body temperature and ...
Tópico(s): Traditional Chinese Medicine Analysis
2021 - Oxford University Press | Journal of Pharmacy and Pharmacology
Madhur Kulkarni, Amarjitsing Rajput, Aditi Kasar, Shruti Thorat,
Background: Borneol, a bicyclic monoterpene belonging to the class of camphene, is sourced from Blumea balsamifera, Cinnamonum camphora (L.) ... documents almost 1000 years of clinical use of borneol as an adjuvant as well as an active ... into the array of pharmacological activities elicited by borneol along with their underlying mechanisms. Methods: Apart from ... evidence of a variety of pharmacological effects of borneol. The current work involved critical evaluation of the ... and patented literature revealing various pharmacodynamic activities of borneol alone and in combination with other actives. The ...
Tópico(s): Medicinal Plants and Neuroprotection
2021 - | The Natural Products Journal
Zerui Yang, Wenli An, Shanshan Liu, Yuying Huang, Chunzhu Xie, Song Huang, Xiasheng Zheng,
Dextrorotatory borneol (D-borneol), a cyclic monoterpene, is widely used in traditional Chinese medicine as an efficient topical analgesic drug. Fresh leaves of ... camphor, are the main sources from which D-borneol is extracted by steam distillation, yet with low yields. Insufficient supply of D-borneol has hampered its clinical use and production of ... for a long time. Biological synthesis of D-borneol offers an additional approach; however, mechanisms of D-borneol biosynthesis remain mostly unresolved. Hence, it is important ...
Tópico(s): Plant Gene Expression Analysis
2020 - PeerJ, Inc. | PeerJ
Aye Aye Khine, Ming‐Yeh Yang, Anren Hu, Guang-Huey Lin, Yee-Huan Toh, Hao‐Ping Chen,
(–)-Borneol is a bicyclic plant secondary metabolite. Optically pure (–)-borneol can only be obtained from plants, and demand exceeds supply in China. In contrast, chemically synthesized borneol contains four different stereoisomers. A strain of Pseudomonas ... TCU-CK1, isolated in Hualien, Taiwan, can accumulate (–)-borneol in growth culture and selectively degrades the other three isomers when chemically synthesized borneol is used as sole carbon source. This (–)-borneol production method can be scaled-up for production ...
Tópico(s): Ginseng Biological Effects and Applications
2020 - Elsevier BV | Enzyme and Microbial Technology
Zeng Wang, Qinglin Li, Liang Xia, Xia Li, Caixing Sun, Qiong Wang, Xinjun Cai, Guonong Yang,
... In our previous study, we clearly established that borneol opens the blood-brain tumor barrier and its related mechanism.However, the effects of borneol itself on glioma proliferation have not yet been ... in this study, we evaluated the effect of borneol on glioma by constructing in vivo SD rat ... primary cultured glioma cell model.We found that borneol could suppress the proliferation of primary glioma cells ... Further, we measured the apoptosis effect induced by borneol in human primary cultured glioma cells.The results ...
Tópico(s): Cancer, Lipids, and Metabolism
2020 - Ivyspring International Publisher | Journal of Cancer
Jin‐Ya Wang, Xiaoyan Dong, Zhiwei Yu, Lei Ge, Lu Lu, Ling Ding, Weihua Gan,
... study aims to explore the pharmacological effect of borneol on asthma and its underlying mechanism. We constructed ... induced asthma model to investigate the effect of borneol on asthma in mice. HE and PAS staining was used to detect the effect of borneol on pathological change of mice with asthma. Inflammatory ... PCR was used to explore the effect of borneol on microRNAs expression. Cell proliferation of CD4 + T ... pten expression and Akt activation. We found that borneol significantly alleviated asthma progression in mice. Borneol inhibited ...
Tópico(s): Chemokine receptors and signaling
2020 - Elsevier BV | International Immunopharmacology
Phuong Thao Nguyen, Seon Hui Jang, Santosh Rijal, Soo Joung Park, Seong Kyu Han,
... myelinated Aδ and unmyelinated C primary afferent fibers. Borneol, one of the valuable timehonored herbal ingredients in ... to date, little is known as to how borneol acts on the SG neurons of the Vc. ... the antinociceptive mechanism responding for the actions of borneol on the SG neurons of the Vc in ... voltage-clamp mode, holding at -60 mV, the borneol-induced non-desensitizing inward currents were not affected ... 5-phosphonopentanoic acid, an NMDA receptor antagonist. However, borneol-induced inward currents were partially decreased in the ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2020 - The Korean Society of Pharmacology | Korean Journal of Physiology and Pharmacology
Rui Ma, Ping Su, Baolong Jin, Juan Guo, Mei Tian, Liuying Mao, Jinfu Tang, Tong Chen, Chang‐Jiang‐Sheng Lai, Wen Zeng, Guanghong Cui, Luqi Huang,
... terpenoids, is an important commercial plant. The monoterpenes borneol and camphor are highly desired compounds that have ... the key enzymes in the biosynthetic pathway of borneol and camphor in C. camphora remains unknown, which ... to these natural products. Here, the chirality of borneol and camphor were identified in C. camphora leaves. Besides the main (+)-borneol and (+)-camphor, C. camphora also contains small amounts of (−)-borneol and (−)-camphor. Then, CcBDH3 – an efficient (+)-borneol dehydrogenase (BDH) – was identified that catalyzed (+)-borneol into (+)- ...
Tópico(s): Plant tissue culture and regeneration
2020 - Elsevier BV | Plant Physiology and Biochemistry
Sapana Bansod, Shrilekha Chilvery, Mohd Aslam Saifi, Tridip J. Das, Hui Tag, Chandraiah Godugu,
Abstract Borneol is a commonly used flavouring substance in traditional Chinese medicine, which possesses several pharmacological activities including analgesic, ... this study was to investigate the effects of borneol on cerulein‐induced acute pancreatitis (AP) model. Swiss albino mice were pretreated with borneol (100 and 300 mg/kg) daily for 7 ... μg/kg/hr, intraperitoneally). The protective effect of borneol was studied by biochemical, enzyme linked immunosorbent assay, histological, immunoblotting, and immunohistochemical analysis. Oral administration of borneol significantly attenuated pancreatic damage by reducing amylase, lipase ...
Tópico(s): Paraoxonase enzyme and polymorphisms
2020 - Wiley | Environmental Toxicology
Ming‐Yeh Yang, Aye Aye Khine, Jen‐Wei Liu, Hui‐Chen Cheng, Anren Hu, Hao‐Ping Chen, Tzenge‐Lien Shih,
Borneol is a plant terpene commonly used in traditional Chinese medicine. Optically pure (+)-borneol and (-)-borneol can be obtained by extraction from the plants Dipterocarpaceae and Blumea balsamifera, respectively. "Synthetic borneol" is obtained from the reduction of (±)-camphor to lead to four different stereoisomers: (+)-isoborneol, (-)-isoborneol, (+)-borneol, and (-)-borneol. In contrast, "semi-synthetic borneol" is produced from the reduction of natural camphor, (+)-camphor, to afford two isomers: (-)-isoborneol and (+)-borneol. We established a convenient method to identify them ...
Tópico(s): Plant biochemistry and biosynthesis
2018 - Wiley | Chirality
Produção Nacional
Revisado por pares
Stefânia E. Santos, Fernanda Pires Rodrigues de Almeida Ribeiro, Pedro Modesto Nascimento Menezes, Luiz Antonio Miranda de Souza Duarte Filho, Jullyana de Souza Siqueira Quintans, Lucindo José Quintans‐Júnior, Fabrício Souza Silva, Luciano Augusto de Araújo Ribeiro,
Abstract The monoterpene alcohol (−)‐borneol has many biological effects such as sedative, anti‐inflammatory, analgesic, anti‐nociceptive, antithrombotic and vasorelaxant effects. Our objective in this ... was to investigate the mechanism of action of (−)‐borneol and determine its vasorelaxant effect. (−)‐Borneol was tested on isolated aortic rings contracted with ... and potassium channels on the relaxing effect of (−)‐borneol. In this work, (−)‐borneol induced a relaxant effect in aortic rings, with ... AP and glibenclamide demonstrates that the effect of (−)‐borneol was modified in the presence of L‐ NAME , ...
Tópico(s): Phytochemistry and Biological Activities
2018 - Wiley | Fundamental and Clinical Pharmacology
Qunlin Zhang, Bingmei M. Fu, Zhang‐Jin Zhang,
... bioavailability due to the blood–brain barrier (BBB). Borneol is a naturally occurring compound in a class ... evidence confirms that the 'orifice-opening' effect of borneol is principally derived from opening the BBB. Borneol is therefore believed to be an effective adjuvant ... information accumulated over the past two decades on borneol's chemical features, sources, toxic and kinetic profiles, ... and pharmaceutical forms. The BBB-opening effect of borneol is a reversible physiological process characterized by rapid ...
Tópico(s): Ginger and Zingiberaceae research
2017 - Taylor & Francis | Drug Delivery
Dandan Luo, Xiaoying Chen, Zhenbiao Zhang, Chao‐Yue Sun, Yifeng Zheng, Yuhong Liu, Xiufen Wang, Qi Wang, Janis Ya-Xian Zhan, Ziren Su,
... medicine, osthole is commonly used in combination with borneol to obtain improved pharmacological effects. The aim of ... present study was to investigate the effect of borneol enantiomers on the pharmacokinetics of osthole. An appropriate ... oral administration of osthole alone or combined with borneol in rats, blood samples were collected and analyzed ... between osthole administration alone and co‑administration with borneol. When combined with synthetic borneol, the AUC0‑t, AUC0‑∞ and Cmax of osthole ... F decreased by 51.251%. When combined with (+)‑borneol, the AUC0‑t, AUC0‑∞ and Cmax of osthole ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2017 - Spandidos Publishing | Molecular Medicine Reports
Shu Wang, Dan Zhang, Jinsheng Hu, Qi Jia, Wei Xu, Deyuan Su, Hualing Song, Zhichun Xu, Jianmin Cui, Ming Zhou, Jian Yang, Jianru Xiao,
... almost pure chemical with a chemical composition of (+)‐borneol and has been historically used as a topical ... for millennia. However, the clinical efficacy of topical borneol lacks stringent evidence‐based clinical studies and verifiable ... mechanism. We examined the analgesic efficacy of topical borneol in a randomized, double‐blind, placebo‐controlled clinical ... 122 patients with postoperative pain. Topical application of borneol led to significantly greater pain relief than placebo ... TRPM 8 channel as a molecular target of borneol and showed that topical borneol‐induced analgesia was ...
Tópico(s): Dermatology and Skin Diseases
2017 - Springer Nature | EMBO Molecular Medicine
Jingya Chen, Xiangtao Huang, Junjun Wang, Yong Chen,
... the metabolism of around 8% of clinical drugs. Borneol has been widely used in traditional Chinese medicine ... thousands of years. There are many studies about borneol-induced promoting penetration role for a number of ... there is no report involved the effect of borneol on hepatic CYP2B. The present work studied the in vivo effect of borneol on the expression and activity of rat hepatic ... The results indicated that the oral administration of borneol (33, 100 and 300 mg/kg/d) to ... respectively compared to the control. Additionally, in the borneol pre-dosing (300 mg/kg/d for consecutive ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2016 - Elsevier BV | Chemico-Biological Interactions
Hoi-Lung Tsang, Jui-Lin Huang, Yu-Hsuan Lin, Kai-Fa Huang, Pei‐Luen Lu, Guang-Huey Lin, Aye Aye Khine, Anren Hu, Hao‐Ping Chen,
... produced monoterpenes can be degraded by soil microorganisms. Borneol is a plant terpene that is widely used in traditional Chinese medicine. Neither microbial borneol dehydrogenase (BDH) nor a microbial borneol degradation pathway has been reported previously. One borneol-degrading strain, Pseudomonas sp. strain TCU-HL1, was ... pTHL1 (12.6 kbp). Our results suggest that borneol is first converted into camphor by BDH in ... K m values of refolded recombinant BDH for (+)-borneol and (−)-borneol were 0.20 ± 0.01 and ...
Tópico(s): Microbial Natural Products and Biosynthesis
2016 - American Society for Microbiology | Applied and Environmental Microbiology
Tsung‐Jung Ho, Chien-Che Hung, Tzenge‐Lien Shih, Lih‐Ming Yiin, Hao‐Ping Chen,
Borneol is a monoterpene that is widely used in traditional Chinese medicine. There are two different products ... traditional Chinese medicine market, natural and chemically synthesized borneol. Chemically synthesized borneol contains four stereoisomers, (+)-isoborneol, (-)-isoborneol, (-)-borneol, and (+)-borneol. The ratio of these four isomers in chemically synthesized and natural borneol products was determined by gas chromatography mass spectrometry. ... standard regarding the ratio of the four different borneol isomers in both natural and chemically synthesized borneol.
Tópico(s): Phytochemistry and Biological Activities
2016 - Elsevier BV | Journal of Food and Drug Analysis