Andrew Robson, James Collarc, Jon Ashworth, Grania Langdon Down, Andrew Eames, Stella Shamoon, Joanna Hunter, N. C. Cummins, Richard Whitehead, Robert Cole, Neelam Verjee, David Brown, Paul White, Nigel Colborn, Ian Nathan, Maggie Alderson, Jane MacQuitty, Paul Hoggart, Mark Souster, Richard Hobson, Olivia Lichtenstein, Ian Winrow, Michael Evans Defence Editor, Philip Howard, Ian Cobain, Christine Seib, David Chater, Chris Terry, Jeremy Kingston, Nic Hopkins, Alison Kervin, John Mellin, Elizabeth Judge, Gabrielle Starkey, Ellen MacArthur, Mickey Burke, Roger Maynard, Sam Lister, Clare Stewart, Thunderer, Giles Coren, Peter Brown, Alastair Campbell, Ben Webster Transport Correspondent, Mark Griffiths, Chloë Bryan Brown, Hilary Rose, Stewart Tendler Crime Correspondent, Katherine Swift, Alexandra Frean and Ben Hoyle, Dominic Walsh, Ruth Gledhill, Tom Bawden, Debra Craine, Shirley English, Ingrid Mansell and Sarah Butler, Rory Watson, Gary Jacob, David Hands Rugy Correspondent, Dalya Alberge and Helen Studd, Joe Morgan, Jill Dupleix, Rosemary Bennett, Jon Hills-Jones, Ruth Gledhill Religion Correspondent, Owen M. Jubb, Jo Morris, Candida Crewe, Robin Young, Oliver Wright, Stephen Farrell, Oliver Wright Health Correspondent, Randhir Singh Bains, Andy Stephens, Richard Miles and Antonia Senior, Tony Jeapes, Peter Millar, Paul Winder, Rose Shepherd, Alan Millard, Nick Wyke, Sue Corbett, Ian Belcher, Roland Watson, Richard Lloyd Parry, David Hands, Richard Johnson, Chris Johnston, Mel Webb and Richard Hobson, Lucy Huxley, Adrienne May, Matt Dickinson Chief Football Correspondent, Roland Watson and Tim Johnston, Michael T. Helm, Greg Hurst, Jonathan Sacks, Tim Teeman, Nicholas Wapshott, Mark Court, Caroline Merrell Banking Correspondent, R. Gibson, James Hopkin, Angela Jameson, Tom Petherick, Paula Hawkins, John Nalsh, Rachel Newbury, Vanora Bennett, Mary Gold, Nigel Williamson, Oliver Kay, Luke Coppen, Christine Selb, John McDougall, President, Amber Cowan, Stephen Anderton, Claire Bowman, Mark Atherton, George Brock, Rick Broadbent, Jill Sherman Whitehall Editor, Sam Coates, John Hopkins, Christopher Martin-Jenkins, Slân EllIs, Chris Power, Simon de Bruxelles, Hermione Norris, Rob Wright, Virginia Woolf, Elaine Monaghan, Sarah Turner, Gabriel Rozenberg, Raymond Keene, Stella Kenrick, Adam Sage, Matthew Pryor, Roy C. Allison, Lucy Pinney, Peter Stothard, David Walton, Christine Buckley Industrial Editor, Rob Cutler, Greg Hurst Parliamentary Correspondent, Andy Smith, Xan Rice, Pul Hoggart, Chris Campling, Melissa Kite, Russell Hotten, Helen Nugent, Anthony Browne Environment Editor, Peter Neissa, Christopher Martin-Jenkins Chief Cricket Correspondent, Ross Leckie, Oliver August, Nick Hasell, Richard Holledge, Owen Slot Chief Sports Reporter, Austin Spreadbury, Norman Stone, Mike Mulvihill, Bruce MacGregor, Anne Ashworth, James Doran, Melissa Kite Political Correspondent, Mel Webb, Ian Johns, Malcolm Boyden, Christopher Hawtree, George Caulkin, Nick Szczepanik and David McVay, Tim Wapshott, Glen Owen Education Correspondent, Ingrid Mansell, Alan Lee, Anthony Loyd, Mark Court Health Industries Correspondent, Helen Pridham, Ed Dart (Chairman), Fiona Hook, Michael Gove, Richard Beeston, David James, Richard Beeston Diplomatic Editor, David Charter Chief Political Correspondent, Alison Gibson, Jack Malvern Arts Reporter, Helen Pickles, David Sinclair, John Naish, Richard Miles, Graham Searjeant, Annabelle Thorpe, Martin Waller, Kieran Falconer, Michael Horsnell, Christopher Irvine, Caroline Merrell and Abigall Rayner, Danny Baker, Ted Nelstrop, James Jackson, Nigel Hawkes Health Editor, Emma Hartley, Benedict Nightingale, Angela Pitt, Angus Batey, Jonathan Meades, Dr Thomas Stuttaford, Lewis Stretch, Hugh Thompson, Jill Crawshaw, Patrick Dearnley, Richard Morrison, Bill Edgar, Fred Dellar, James Christopher, Abigail Rayner, Marla Harding, Matthew Connolly, John Phillips, Alan Lee Racing Correspondent, Chris King, Andrew Michael, Antonia Senior, Richard Miles and Christine Selb, Will Hide, Aisling Foster, Jan Raath, Jill Hunter, Oliver Kay and Nick Szczepanik, Patience Wheatcroft, Janine di Giovanni, Philip Pank,
... Chris Campling Folk choice Concert and albums Melisma Boubacar Traore Concerts Classical choice Crossword solution: February 8 Charts ...
2003 - Gale Group | TDA
Frédérick Gay, Boubacar Traoré, Josiane Zanoni, Martin Danis, André Fribourg-Blanc,
... this author on: Oxford Academic PubMed Google Scholar Boubacar Traoré, Boubacar Traoré Laboratoire d'Epidémiologie et de Chimiorésistance du Paludisme, ...
Tópico(s): Complement system in diseases
1996 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene
Oumou Maïga‐Ascofaré, Kassoum Kayentao, Boubacar Traoré, Abdoulaye Djimdé, Boubacar Traoré, M. Diallo, Aissata Ongoïba, Didier Doumtabé, Safiatou Doumbo, Mohamed Sahar Traoré, Antoine Dara, Ousmane Guindo, Dao K, Souleymane Coulibaly, F Bougoudogo, Feiko O. ter Kuile, M Danis, Ogobara K. Doumbo,
(See the article by Harrington et al, on pages 224–230, and editorial commentary by Lake and Taylor, on pages 231–233.) Background. In 2003, Mali introduced intermittent preventive therapy in pregnancy (ITPp) with sulfadoxine-pyrimethamine (SP) for the control of malaria in pregnancy, consisting of 2 doses of SP given in the 2nd and 3rd trimester. This widely used regimen, although very effective, leaves many women unprotected from malaria during the last 4-to-8 weeks of gestation, which is a pivotal ...
Tópico(s): Pregnancy and preeclampsia studies
2011 - Oxford University Press | Clinical Infectious Diseases
Mahamadou S. Sissoko, Abdoulaye Dabo, Hamidou Traoré, Mouctar Diallo, Boubacar Traoré, Drissa Konaté, Boubacar Niaré, Moussa Diakité, Bourama Kamaté, Abdrahamane Traoré, Aboudramane Bathily, Amadou Tapily, Ousmane Touré, Sarah Cauwenbergh, Herwig Jansen, Ogobara K. Doumbo,
This study was conducted to determine the efficacy of the antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma haematobium in school aged children.The study was conducted in Djalakorodji, a peri-urban area of Bamako, Mali, using a double blind setup in which As+SMP was compared with praziquantel (PZQ). Urine samples were examined for Schistosoma haematobium on days -1, 0, 28 and 29. ...
Tópico(s): Research on Leishmaniasis Studies
2009 - Public Library of Science | PLoS ONE
Daniel Eibach, Boubacar Traoré, Mourad Bouchrik, Boubacar Coulibaly, Nianégué Coulibaly, Fanta Siby, Guillaume Bonnot, Anne‐Lise Bienvenu, Stéphane Picot,
Malaria rapid diagnostic tests (RDTs) are a useful tool in endemic malaria countries, where light microscopy is not feasible. In non-endemic countries they can be used as complementary tests to provide timely results in case of microscopy inexperience. This study aims to compare the new VIKIA Malaria Ag Pf/Pan™ RDT with PCR-corrected microscopy results and the commonly used CareStart™ RDT to diagnose falciparum and non-falciparum malaria in the endemic setting of Bamako, Mali and the non-endemic ...
Tópico(s): Vector-borne infectious diseases
2013 - BioMed Central | Malaria Journal
Kassoum Kayentao, Hamma Maiga, Robert D. Newman, Meredith McMorrow, Annett Hoppe, Oumar Yattara, Hamidou Traoré, Younoussou Koné, Etienne A. Guirou, Rénion Saye, Boubacar Traoré, Abdoulaye Djimdé, Ogobara K. Doumbo,
Because of the emergence of chloroquine resistance in Mali, artemether-lumefantrine (AL) or artesunate-amodiaquine (AS+AQ) are recommended as first-line therapy for uncomplicated malaria, but have not been available in Mali until recently because of high costs. From July 2005 to January 2006, a randomized open-label trial of three oral antimalarial combinations, namely AS+AQ, artesunate plus sulphadoxine-pyrimethamine (AS+SP), and amodiaquine plus sulphadoxine-pyrimethamine (AQ+SP), was conducted in ...
Tópico(s): Venomous Animal Envenomation and Studies
2009 - BioMed Central | Malaria Journal
Richard Thomson-Luque, Lasse Votborg-Novél, Wanangwa Ndovie, Carolina M. Andrade, Moussa Niangaly, Charalampos Attipa, Nathália F. Lima, Drissa Coulibaly, Didier Doumtabé, Bouréima Guindo, Bourama Tangara, Fayçal Maïga, Abdoulaye K. Koné, Karim Traoré, Kassoum Kayentao, Aissata Ongoïba, Safiatou Doumbo, Mahamadou A. Théra, Boubacar Traoré, Karl B. Seydel, Nuno S. Osório, Sílvia Portugal,
Abstract Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one or more severe malaria symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions have yet been drawn. Here, we apply a series of bioinformatic approaches based on P. falciparum ’s tightly regulated transcriptional pattern during its ~48-hour intraerythrocytic developmental ...
Tópico(s): Invertebrate Immune Response Mechanisms
2021 - Nature Portfolio | Nature Communications
Tuan M. Tran, Shanping Li, Safiatou Doumbo, Didier Doumtabé, Chiung Yu Huang, Seydou Dia, Aboudramane Bathily, Jules Sangala, Younoussou Koné, Abdrahamane Traoré, Moussa Niangaly, Charles Dara, Kassoum Kayentao, Aissata Ongoïba, Ogobara K. Doumbo, Boubacar Traoré, Peter D. Crompton,
In experimental models of human and mouse malaria, sterilizing liver stage immunity that blocks progression of Plasmodium infection to the symptomatic blood stage can be readily demonstrated. However, it remains unclear whether individuals in malaria-endemic areas acquire such immunity.In Mali, 251 healthy children and adults aged 4-25 years who were free of blood-stage Plasmodium infection by polymerase chain reaction (PCR) were enrolled in a longitudinal study just prior to an intense 6-month malaria ...
Tópico(s): Parasites and Host Interactions
2013 - Oxford University Press | Clinical Infectious Diseases
Kassoum Kayentao, Aissata Ongoïba, Anne C Preston, Sara A. Healy, Safiatou Doumbo, Didier Doumtabé, Abdrahamane Traoré, Hamadi Traore, Adama Djiguiba, Shanping Li, Mary Peterson, Shinyi Telscher, Azza H. Idris, Neville K. Kisalu, Kevin Carlton, Leonid Serebryannyy, Sandeep Narpala, Adrian B. McDermott, Martin R. Gaudinski, Siriman Traoré, Hamidou Cisse, Mamadou Keita, Jeff Skinner, Zonghui Hu, Amatigué Zéguimé, Adama Ouattara, M’Bouye Doucoure, Amagana Dolo, Abdoulaye Djimdé, Boubacar Traoré, Robert A. Seder, Peter D. Crompton,
CIS43LS is a monoclonal antibody that was shown to protect against controlled Plasmodium falciparum infection in a phase 1 clinical trial. Whether a monoclonal antibody can prevent P. falciparum infection in a region in which the infection is endemic is unknown.We conducted a phase 2 trial to assess the safety and efficacy of a single intravenous infusion of CIS43LS against P. falciparum infection in healthy adults in Mali over a 6-month malaria season. In Part A, safety was assessed at three escalating ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2022 - Massachusetts Medical Society | New England Journal of Medicine
Laura Ciaffi, Sinata Koulla‐Shiro, Adrien Sawadogo, Cheik Tidiane Ndour, Sabrina Eymard‐Duvernay, Pretty Mbouyap, Liliane Ayangma, Jacques Zoungrana, Ndèye Fatou Ngom Gueye, Mohamadou Diallo, Suzanne Izard, Guillaume Bado, Coumba Touré Kane, Avelin F. Aghokeng, Martine Peeters, Pierre Marie Girard, Vincent Le Moing, Jacques Reynes, Éric Delaporte, Jacques Reynes, Éric Delaporte, Sinata Koulla‐Shiro, C.T. Ndour, Sawadogo Ab, M Seidy, Vincent Le Moing, Alexandra Calmy, Laura Ciaffi, NF Ngom Gueye, PM Girard, S Eholie, JB Guiard-Schmid, Marie‐Laure Chaix, Charles Kouanfack, Ioana Cristina Tita, Brigitte Bazin, Paula Garcia, Vincent Le Moing, S.R. Izard, Sabrina Eymard‐Duvernay, Laura Ciaffi, Martine Peeters, Laetitia Serrano, Amandine Cournil, Éric Delaporte, PR Mbouyap, R. Toby, N.M. Manga, Liliane Ayangma, M. Mpoudi, Ngole J Zoungrana, Mamadou Abdoulaye Diallo, NF Ngom Gueye, AF Aghokeng, Emilande Guichet, Olga Bell, Hortence Abessolo, MR Djoubgang, Godfrey Manirakiza, G Lamarre, T. Mbarga, S. Epanda, Angeline Bikié, T Nké, N. Massaha, E. Nke, D. Bikobo, J Olinga, O. Elat, A Diop, Babacar Diouf, N. Bara, MB Koita Fall, C. Touré Kane, FB Seck, Sophie Hill BA, P. Njantou, A. Ndyaye, Paulin Fao, René Traoré, Yves Sanou, Guillaume Bado, M Coulibaly, Eric Nagaonlé Somé, J. Some, A. Elisée Sié Kambou, A Tapsoba, Diamasso Sombié, S. Sanou, Boubacar Traoré, Philippe Flandre, Camille Michon, J. Drabo, François Simon,
Tópico(s): HIV Research and Treatment
2017 - Elsevier BV | The Lancet HIV
Kassoum Kayentao, Aissata Ongoïba, Anne C Preston, Sara A. Healy, Zonghui Hu, Jeff Skinner, Safiatou Doumbo, Jing Wang, Hamidou Cisse, Didier Doumtabé, Abdrahamane Traoré, Hamadi Traore, Adama Djiguiba, Shanping Li, Mary Peterson, Shinyi Telscher, Azza H. Idris, William C. Adams, Adrian B. McDermott, Sandeep Narpala, Bob C. Lin, Leonid Serebryannyy, Somia P. Hickman, Andrew McDougal, Sandra Vazquez, M.A. REIBER, Judy Stein, Jason G. Gall, Kevin Carlton, Philipp Schwabl, Siriman Traoré, Mamadou Keïta, Amatigué Zéguimé, Adama Ouattara, M’Bouye Doucoure, Amagana Dolo, Sean C. Murphy, Daniel E. Neafsey, Sílvia Portugal, Abdoulaye Djimdé, Boubacar Traoré, Robert A. Seder, Peter D. Crompton,
BackgroundSubcutaneous administration of the monoclonal antibody L9LS protected adults against controlled Plasmodium falciparum infection in a phase 1 trial. Whether a monoclonal antibody administered subcutaneously can protect children from P. falciparum infection in a region where this organism is endemic is unclear.MethodsWe conducted a phase 2 trial in Mali to assess the safety and efficacy of subcutaneous administration of L9LS in children 6 to 10 years of age over a 6-month malaria season. ...
Tópico(s): Travel-related health issues
2024 - Massachusetts Medical Society | New England Journal of Medicine
Safiatou Doumbo, Tuan M. Tran, Jules Sangala, Shanping Li, Didier Doumtabé, Younoussou Koné, Abdrahamane Traoré, Aboudramane Bathily, Nafomon Sogoba, Michel Emmanuel Coulibaly, Chiung‐Yu Huang, Aissata Ongoïba, Kassoum Kayentao, Mouctar Diallo, Dramane Zongo, Thomas B. Nutman, Peter D. Crompton, Ogobara K. Doumbo, Boubacar Traoré,
Background Malaria and schistosomiasis often overlap in tropical and subtropical countries and impose tremendous disease burdens; however, the extent to which schistosomiasis modifies the risk of febrile malaria remains unclear. Methods We evaluated the effect of baseline S. haematobium mono-infection, baseline P. falciparum mono-infection, and co-infection with both parasites on the risk of febrile malaria in a prospective cohort study of 616 children and adults living in Kalifabougou, Mali. Individuals ...
Tópico(s): Global Maternal and Child Health
2014 - Public Library of Science | PLoS neglected tropical diseases
G. Bassani, N. Saunier, Boubacar Traoré, J.‐C. Raynal, A. Foti, G.S. Pappalardo,
The elastic scattering cross sections of 28 MeV 6Li ions from the nuclei 11B, 12C and 13C were analyzed using the optical model. The analysis has been extended to other 6Li elastic scattering data on 16O (29.8 MeV) and on 12C (24.5 and 30.6 MeV) previously measured elsewhere. The fits obtained with the usual six-parameter Woods-Saxon potential are good. Parameter ambiguities were studied and the results of the analysis were compared with the predictions of the folding model.
Tópico(s): Atomic and Molecular Physics
1972 - Elsevier BV | Nuclear Physics A
Greta E. Weiss, Peter D. Crompton, Shanping Li, Laura A. Walsh, Susan Moir, Boubacar Traoré, Kassoum Kayentao, Aissata Ongoïba, Ogobara K. Doumbo, Susan K. Pierce,
Abstract Epidemiological observations in malaria endemic areas have long suggested a deficiency in the generation and maintenance of B cell memory to Plasmodium falciparum (Pf) in individuals chronically reinfected with the parasite. Recently, a functionally and phenotypically distinct population of FCRL4+ hyporesponsive memory B cells (MBCs) was reported to be expanded in HIV-infected individuals with high viral loads. In this study, we provide evidence that a phenotypically similar atypical MBC ...
Tópico(s): Complement system in diseases
2009 - American Association of Immunologists | The Journal of Immunology
Boubacar Traoré, Younoussou Koné, Safiatou Doumbo, Didier Doumtabé, Abdramane Traoré, Peter D. Crompton, Marko Mircetic, Chiung‐Yu Huang, Kassoum Kayentao, Alassane Dicko, Issaka Sagara, Ruth D. Ellis, Kazutoyo Miura, Agnès Guindo, Louis H. Miller, Ogobara K. Doumbo, Susan K. Pierce,
Tópico(s): Immune Cell Function and Interaction
2009 - Elsevier BV | Vaccine
Xuerong Li, Huiqing Chen, Noemí Bahamontes‐Rosa, Jürgen F. J. Kun, Boubacar Traoré, Peter D. Crompton, Athar H. Chishti,
The resistance of malaria parasites to current anti-malarial drugs is an issue of major concern globally. Recently we identified a Plasmodium falciparum cell membrane aspartyl protease, which binds to erythrocyte band 3, and is involved in merozoite invasion. Here we report the complete primary structure of P. falciparum signal peptide peptidase (PfSPP), and demonstrate that it is essential for parasite invasion and growth in human erythrocytes. Gene silencing suggests that PfSPP may be essential ...
Tópico(s): Drug Transport and Resistance Mechanisms
2009 - Elsevier BV | Biochemical and Biophysical Research Communications
Myaing M. Nyunt, I. Adam, Kassoum Kayentao, Jan van Dijk, Philip E. Thuma, Katya Mauff, Francesca Little, Yasmin Cassam, Etienne A. Guirou, Boubacar Traoré, O Doumbo, David J. Sullivan, Peter J. Smith, Karen I. Barnes,
Malaria during pregnancy is associated with maternal and fetal morbidity and mortality. In order to minimize the burden, sulfadoxine–pyrimethamine (SP) is widely used in Africa as an intermittent preventive treatment of malaria in pregnancy (IPTp). However, only limited data are available on the pharmacokinetics of sulfadoxine and pyrimethamine during pregnancy. We conducted a prospective, self-matched, multicenter study of 98 pregnant women in four African countries in order to determine the effects ...
Tópico(s): Drug Transport and Resistance Mechanisms
2009 - Wiley | Clinical Pharmacology & Therapeutics
Peter D. Crompton, Kazutoyo Miura, Boubacar Traoré, Kassoum Kayentao, Aissata Ongoïba, Greta E. Weiss, Safiatou Doumbo, Didier Doumtabé, Younoussou Koné, Chiung‐Yu Huang, Ogobara K. Doumbo, Louis H. Miller, Carole A. Long, Susan K. Pierce,
Immunity to the asexual blood stage of Plasmodium falciparum is complex and likely involves several effector mechanisms. Antibodies are thought to play a critical role in malaria immunity, and a corresponding in vitro correlate of antibody-mediated immunity has long been sought to facilitate malaria vaccine development. The growth inhibition assay (GIA) measures the capacity of antibodies to limit red blood cell (RBC) invasion and/or growth of P. falciparum in vitro. In humans, naturally acquired ...
Tópico(s): Parasites and Host Interactions
2009 - American Society for Microbiology | Infection and Immunity
Jean-Bernard Lékana Douki, Boubacar Traoré, Fábio Trindade Maranhão Costa, Thierry Fusaı̈, Bruno Pouvelle, Yvon Sterkers, Artur Scherf, Jürg Gysin,
Plasmodium falciparum parasites express variant adhesion molecules on the surface of infected erythrocytes (IEs), which act as targets for natural protection. Recently it was shown that IE sequestration in the placenta is mediated by binding to chondroitin sulfate A via the duffy binding-like (DBL)–γ3 domain ofP falciparum erythrocyte membrane protein 1 (PfEMP1CSA). Conventional immunization procedures rarely result in the successful production of monoclonal antibodies (mAbs) against such conformational ...
Tópico(s): Complement system in diseases
2002 - Elsevier BV | Blood
Mathieu Nacher, Pratap Singhasivanon, Boubacar Traoré, Suparp Vannaphan, Frédérick Gay, D Chindanond, Jean‐François Franetich, Dominique Mazier, Sornchai Looareesuwan,
Following a study showing an association between Ascaris and protection from cerebral malaria, we hypothesized helminths may have induced protection through immunoglobulin E (IgE) and the CD23/NO pathway. We compared the prevalence of helminth infections in 67 cerebral malaria patients and 217 hyperparasitemic controls with no complications. For 24 cerebral malaria cases and 56 controls, we compared reactive nitrogen intermediates (RNI) concentrations and their correlations to total IgE and sCD23 ...
Tópico(s): Malaria Research and Control
2002 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Dorina Bustos, J. Enrico H. Lazaro, Frédérick Gay, Anne Pottier, Catherine J. Laracas, Boubacar Traoré, Bertrand Diquet,
The efficacy and kinetics of the combination chloroquine plus sulfadoxine‐pyrimethamine (CQ + SP), given sequentially and simultaneously, were investigated in 32 patients with acute uncomplicated Plasmodium falciparum malaria in Palawan Island, the Philippines. Group 1 with 11 patients received oral CQ 25 mg/kg bw over 3 days followed by a single dose of SP (three tablets 250 mg S + 25 mg P) on Day 4 (CQ0 + SP4). Group 2 with 21 patients received a loading dose of CQ 10 mg/kg plus a single dose of SP three ...
Tópico(s): Trypanosoma species research and implications
2002 - Wiley | Tropical Medicine & International Health
Mathieu Nacher, Pratap Singhasivanon, Sombat Treeprasertsuk, Suparp Vannaphan, Boubacar Traoré, S Looareesuwan, Frédérick Gay,
Although human infection with Ascaris appears to be associated with protection from cerebral malaria, there are many potential socio-economic and nutritional confounders related to helminth infection that need to be considered. In a hospital-based study, 37 cases of cerebral malaria and 61 cases of non-severe malaria with high parasite biomass (i.e. hyperparasitaemia and/or circulating schizonts) answered a structured questionnaire and were screened for intestinal helminths. Logistic regression was ...
Tópico(s): Parasite Biology and Host Interactions
2002 - Maney Publishing | Annals of Tropical Medicine and Parasitology
Fábio Trindade Maranhão Costa, Thierry Fusaı̈, Daniel Parzy, Yvon Sterkers, Marylin Torrentino, Jean-Bernard Lékana Douki, Boubacar Traoré, Stéphane Pêtres, Artur Scherf, Jürg Gysin,
Maternal malaria is associated with the sequestration, in the placenta, of Plasmodium falciparum-infected erythrocytes onto chondroitin sulfate A (CSA), via the duffy binding-like (DBL)-gamma3 domain of the P. falciparum erythrocyte membrane protein 1 (PfEMP1(CSA)) (DBL-gamma3(CSA)). The production of antibodies against CSA-binding infected erythrocytes (IEs(CSA)) is correlated with resistance to maternal malaria in multiparous women. We produced recombinant DBL-gamma3(CSA) (rDBL-gamma3(CSA)) in insect ...
Tópico(s): Research on Leishmaniasis Studies
2003 - Oxford University Press | The Journal of Infectious Diseases
Produção Nacional
Revisado por pares
Bruno Pouvelle, Boubacar Traoré, Paulo Afonso Nogueira, Bruno Pradines, Catherine Lépolard, Jürg Gysin,
Although chondroitin-4-sulfate (CSA) is expressed throughout the microvasculature and CSA-binding infected erythrocytes (IECSA) cytoadhere to lung and brain endothelial cells and sequester in male Saimiri sciureus this phenotype seems to be dependent on the presence of a placenta to develop. This contradiction was investigated by modeling the interactions and cytoadhesion parameters in the microvasculature. Mixtures of IEs interacting with CSA, CD36, or intercellular adhesion molecule 1 were incubated ...
Tópico(s): Immune Response and Inflammation
2003 - Oxford University Press | The Journal of Infectious Diseases
Jean-Bernard Lekana Douki, Yvon Sterkers, Catherine Lépolard, Boubacar Traoré, Fábio Trindade Maranhão Costa, Artur Scherf, Jürg Gysin,
Abstract Recent findings have challenged the current view of Plasmodium falciparum (P falciparum) blood-stage biology by demonstrating the cytoadhesion of early ring-stage–infected erythrocytes (rIEs) to host endothelial cells and placental syncytiotrophoblasts. The adhesion of rIEs was observed only in parasites that bind to the placenta via chondroitin sulfate A (CSA). In this work, a panel of mouse monoclonal antibodies (mAbs) that specifically inhibit cytoadhesion of rIEs but not of mature IEs was ...
Tópico(s): Complement system in diseases
2003 - Elsevier BV | Blood
Peter D. Crompton, Boubacar Traoré, Kassoum Kayentao, Safiatou Doumbo, Aissata Ongoïba, Seidina A. S. Diakité, Michael Krause, Didier Doumtabé, Younoussou Koné, Greta E. Weiss, Chiung‐Yu Huang, Seydou Doumbia, Aldiouma Guindo, Rick M. Fairhurst, Louis H. Miller, Susan K. Pierce, Ogobara K. Doumbo,
The World Health Organization (WHO) recently recommended that the time to first malaria episode serve as the primary end point in phase III malaria vaccine trials--the first of which will be held in Africa. Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (HbS) are known to protect against malaria in Africa, their impact on this end point has not been investigated.A longitudinal study of 225 individuals aged 2-25 years was conducted in Mali. The association between common ...
Tópico(s): Mosquito-borne diseases and control
2008 - Oxford University Press | The Journal of Infectious Diseases
Greta E. Weiss, Boubacar Traoré, Kassoum Kayentao, Aissata Ongoïba, Safiatou Doumbo, Didier Doumtabé, Younoussou Koné, Seydou Dia, Agnès Guindo, Abdramane Traoré, Chiung‐Yu Huang, Kazutoyo Miura, Marko Mircetic, Shanping Li, Amy Baughman, David L. Narum, Louis H. Miller, Ogobara K. Doumbo, Susan K. Pierce, Peter D. Crompton,
Immunity to Plasmodium falciparum (Pf) malaria is only acquired after years of repeated infections and wanes rapidly without ongoing parasite exposure. Antibodies are central to malaria immunity, yet little is known about the B-cell biology that underlies the inefficient acquisition of Pf-specific humoral immunity. This year-long prospective study in Mali of 185 individuals aged 2 to 25 years shows that Pf-specific memory B-cells and antibodies are acquired gradually in a stepwise fashion over years ...
Tópico(s): Complement system in diseases
2010 - Public Library of Science | PLoS Pathogens
Peter D. Crompton, Matthew A. Kayala, Boubacar Traoré, Kassoum Kayentao, Aissata Ongoïba, Greta E. Weiss, Douglas M. Molina, Chad Burk, Michael Waisberg, Algis Jasinskas, Xiaolin Tan, Safiatou Doumbo, Didier Doumtabé, Younoussou Koné, David L. Narum, Xiaowu Liang, Ogobara K. Doumbo, Louis H. Miller, Denise L. Doolan, Pierre Baldi, Philip L. Felgner, Susan K. Pierce,
Abs are central to malaria immunity, which is only acquired after years of exposure to Plasmodium falciparum ( Pf ). Despite the enormous worldwide burden of malaria, the targets of protective Abs and the basis of their inefficient acquisition are unknown. Addressing these knowledge gaps could accelerate malaria vaccine development. To this end, we developed a protein microarray containing ∼23% of the Pf 5,400-protein proteome and used this array to probe plasma from 220 individuals between the ages of ...
Tópico(s): Mosquito-borne diseases and control
2010 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Kassoum Kayentao, Mary Mungai, Monica E. Parise, Mamoudou Kodio, Abdoul Salam Keita, Drissa Coulibaly, Boubacar Maïga, Boubacar Traoré, Ogobara K. Doumbo,
Malaria infection during pregnancy is associated with adverse consequences including low birth weight (LBW) and maternal anemia, particularly in primigravidae and secundigravidae. In preparation for a clinical trial of the efficacy of chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) containing prevention regimens during pregnancy, we conducted a one-year cross sectional study in Koro and Bandiagara, Mali using an assessment methodology developed by the Centers for Disease Control and Prevention ( ...
Tópico(s): Parasites and Host Interactions
2007 - Elsevier BV | Acta Tropica
Amed Ouattara, Safiatou Doumbo, Rénion Saye, Abdoul Habib Béavogui, Boubacar Traoré, Abdoulaye Djimdé, Amadou Niangaly, Kassoum Kayentao, Mouctar Diallo, Ogobara K. Doumbo, Mahamadou A. Théra,
Malaria is a major public health problem in Mali and diagnosis is typically based on microscopy. Microscopy requires a well trained technician, a reliable power source, a functioning microscope and adequate supplies. The scarcity of resources of community health centres (CHC) does not allow for such a significant investment in only one aspect of malaria control. In this context, Rapid Diagnostic Tests (RDTs) may improve case management particularly in remote areas.This multicentre study included 725 ...
Tópico(s): Viral Infections and Vectors
2011 - BioMed Central | Malaria Journal