Martin Raden, Thomas Wallach, Milad Miladi, Yuanyuan Zhai, Christina Krüger, Zoé J. Mossmann, Paul Dembny, Rolf Backofen, Seija Lehnardt,
... regulation. Here, we introduce a machine learning approach, BrainDead, to identify oligonucleotides that act as ligands for ... TLR)7/8, thereby triggering an immune response. BrainDead was trained on activation data obtained from in ... and experiments confirms the robustness and power of BrainDead. The results provide new insight into the mechanisms of how miRNAs act as TLR ligands. Eventually, BrainDead implements a generic machine learning methodology for learning ...
Tópico(s): interferon and immune responses
2021 - Taylor & Francis | RNA Biology
J Cason, Kelth Westhead, John Dugdale, Joe Elder, Nigel Sherwin, Mark Strong, Barbara Hall, Robert Craik, Simon Armitage, Chris Curtis, David Mills, Peter Whittle, Sally Brock, Martyn Powls, Nicholas Rufford, Jason Dawe, Laura Bailey, Pam Barrett, Professor Gideon Garter, Kay Carter, Jonathan Miller, Bruce Millar, Andrew Longmore, Jane Mulkerrins, Susan d'Arcy, Ian Critchiey, Gareth Walsh, Phil Green, Frank Whitford, Timothy Garton Ash, Ivo Tennant, David Landers, Matthew Davis, Barry J Holmes, Caroline Brannigan, Ferdinand Mount, David Gower, Keith Wood, Kate reardon, Vivek Singh, Chris Mackey, Allan Brown, P D, David Smith, Tim Richards, Richard Bond, Steven Poole, David Cracknell Political Editor, Nick Pitt, Neil Wormald, E P, Andrew Sullivan, Robert Fox, Clive Davis, Ian Poulter, Ed Balls, Jemima French, Joseph Dunn, Martin James, Simon Wilde, B M, Robert Winnett, Jeremy Seal, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Adrian Furnham, Robert Hewison, Peter Wilson, Rosie Millard, David Dougill, Daisy de Villeneuve, Paul Durkin, Eva Celer, Alan Rhodes, Isabella Tree, Steve Boyd, David Hewson, David Elstein, D Milburn, David Bond, Frank Dobson, Angus Palmer, Margarette Driscoll, Hugh Canning, Lucy Rouse, Jeremy Clarkson, Ryan Gilbey, Philip Smith, Peter Conradi, Edward Porter, Stewart Lee, Victoria Segal, Michael Portillo, Patricia Nicol, Anthony Peregrine, Henry Schukman, Sarah Dempster, Theresa Villiers, Dave Pollard, Shirely Williams, Richard Need, Richard Fletcher, Chitralekha Mehta, Ziad Al-Najim, Greg Struthers, George Perry, Lydia Slater, Domnici Bates, Adam Nathan, J Atherton, Andrew Porter Deputy Political Editor, Grand Sums, Talib Choudhry, Ian Wright, Johnathan Northcroft, Susan D'Arcy, J A Charial, Stuart Morris, Susan Exshaw, Paul Donovan, Adam Nathan Defence Correspondent, Richard Titchener, Penelope Hobhouse, Vincent Crump, Paul Kimmage, Hugh McIlvanney, Lee Taylor, Frank Walsh, Chris Woodhead, Richard Vernon, Lucinda Kemeny, Jasper Gerard, Alan Broad, Iain Gately, David Turner, Philippa Forrester, Garth Pearce, Nicholas Hellen, John Follain, Vanora Bennett, Paul Driver, Ian Hawkey, Shelley Von Strunckel, Alex Clark, Christopher Morgan, David Leppard, Phill Baker, Ed Gorman, Alicia Wyllie, Dave Hannigan, Richard Girling, Mark Edwards, Rachel Bridge, Trevor Hamley, Stephen Amidon, Bonnie Rakhit, Peter Koening, Susan Clark, Tim Clifford, Natalie Garham, Blower, Nell Wormald, Christina Lamb, Hugh Pearmen, Lois Rogers, Bob Graham, Raymond Keene, Chris Rawlinson, Gareth Huw Davies, Cosmo Landesman, Zoe Brennan, Denis Pallis, Robbie Hudson, Les Baux de Provence, Diana Wright, Catherine Turner, Dr Mark Tilden, Barry Flatman tennis correspondent, Stephen Jones, Dominic O'Connell, Peter Koenig, Barry Flatman, Louise Armitstead, Michael Wright, Robbie Burns, Imogen Edwards-Jones, Adrienne Connors, Lynda Mourad, Caroline Donald, Jeremy Lewis, Rob Ryan, Jessica Brinton, David Walsh, Barry Flatman Tennis Correspondent, John Stern, Trevor Lewis, Sally Klnnes, Gareth Southgate, Bryan Appleyard, Helen Stewart, Sarah Keenlyside, Colin McDowell, Stephen Armstrong, John Elliott, Burlington Bertie, Bethan Cole, Victoria O'brien, Roland White, Dr Leyla Sanai, Shane Watson, Sarah Kate Templeton, Maurice Chittenden, Philip Johnstone, Richard Rae, Mark Franchetti, Ray Hutton, George Lucas, Jon Ungoed-Thomas, Dharmasiri Agalawatta, Jonathan Leake, Brendan Simms, Sophie Kirkham, Dan Box, Mike Smith, Clare Francis, T C, John Harlow, Niall Ferguson, Barry Collins, Hunter Davies, Tony Jacklin, John Waples, A A Gill, Lanie Goodman, Melanie McDonagh, Matthew Campbell, Denis Walsh, John Carey, Mary Braid, Simon Jenkins, Stephen Pettitt, Jonathan Leake Science Editor, Imre Karacs, Justin Sparks, Sally Kinnes, Naomi Caine, Daniel Emery, William Simons, Brian Doogan, Ben Dowell, John Aizlewood, Peter Schmeichel, James Knight, Mark Hodson, Andrew Frankel, D Robinson, Joe Lovejoy, Jonathan Futrell, Graham Norwood, Victor Bryant, David Budworth, William Lewis Business editor, Hugh Pearman, Andrew Davidson, Dan Cairns, Simon Sebag Montefiore, John Green, Stewart Mitchell, John Wapies, David Smith Economics Editor, Matt Roberts, Susannah Price, Paul Cairns, Sarah Baxter, Chris Feetenby, Mat Loup, Matthew Goodman, Nick Austin, India Knight, Kate Spicer, Simon Howard, Peter Clowes, Nina Goswami, Tom Holland, Barry Newcombe, Richard Lewis, Sian Griffiths, Karen Robinson, Trevor Phillips,
... of the day Making Waves (ITV1, 9pm) Most braindead Kenny vs Spenny (FX, 10pm) Shades of Gray ...
2004 - Gale Group | Sunday Times HA GDA
David E.R. Sutherland, Michael W. Steffes, G. Eric Bauer, Darlene McManus, Bran D. Noe, John S. Najarian,
... of Langerhans from fresh human pancreata removed from braindead cadavers. Comparison of the tissue insulin/amylase ratios ...
Tópico(s): Cannabis and Cannabinoid Research
1974 - Elsevier BV | Journal of Surgical Research
Uwe Hesse, David E.R. Sutherland,
... gt;300 IU/L. In 51 of 94 braindead cadaver pancreas donors in whom plasma glucose determinations ...
Tópico(s): Renal Transplantation Outcomes and Treatments
1989 - American Diabetes Association | Diabetes
Giuseppe Bello, G. Paliani, Maria Giuseppina Annetta, Alfredo Pontecorvi, Massimo Antonelli,
... as caloric restriction, cardiac disease, acute renal failure, braindead potential donors, and burn patients. Treating patients with ...
Tópico(s): Pituitary Gland Disorders and Treatments
2009 - Bentham Science Publishers | Current Drug Targets
Zhu Ying, Urs D. Schmid, Judith E. Schmid, Christian Heß,
... obtain MEPs in 14 instances; 2) only in braindead patients were all EPs abolished simultaneously and bilaterally; ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
1992 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Anthony Rostron, Vassilios S. Avlonitis, David M.W. Cork, Danielle S. Grenade, John A. Kirby, John H. Dark,
... lung tissue (IL-1β and CINC-1) in braindead animals compared to controls. Correction of neurogenic hypotension ...
Tópico(s): Anesthesia and Neurotoxicity Research
2008 - Wolters Kluwer | Transplantation
... is replaced with a liver obtained from a braindead or living donor. When the donor liver is ...
Tópico(s): Liver Disease Diagnosis and Treatment
2005 - SAGE Publishing | Journal of the Royal Society of Medicine
Blanca Rubı́, Sanda Ljubicic, Shirin Pournourmohammadi, Stefania Carobbio, Mathieu Armanet, Clarissa Bartley, Pierre Maechler,
... experiments. For human islets, pancreata were harvested from braindead donors and islets isolated after enzymatic ductal perfusion ...
Tópico(s): Diabetes Management and Research
2005 - Elsevier BV | Journal of Biological Chemistry
Jean‐Pierre Goarin, Sophie Cohen, Bruno Riou, Yves Jacquens, R. Guesde, Françoise Le Bret, André Aurengo, Pierre Coriat,
... in potential heart donors remain controversial. Thirty-seven braindead patients were randomly and blindly allocated to receive ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
1996 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Jean‐Pierre Goarin, Sophie Cohen, Bruno Riou, Yves Jacquens, R. Guesde, Françoise Le Bret, André Aurengo, Pierre Coriat,
... in potential heart donors remain controversial. Thirty-seven braindead patients were randomly and blindly allocated to receive ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
1996 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Shogo Okamoto, Carlos Otávio Corso, Rosmarie Leiderer, Wolfgang Rascher, Yuzo Yamamoto, Yoshio Yamaoka, K. Meßmer,
Abstract Hypotension in braindead organ donors is considered a determinant factor of graft viability. The aim of this study was to elucidate the ...
Tópico(s): Liver Disease and Transplantation
2000 - Springer Science+Business Media | Transplant International
Pleuni E. Hooijman, Albertus Beishuizen, Monique C. de Waard, Frances S. de Man, Wytze Vermeijden, Pascal Steenvoorde, R. Arthur Bouwman, Wies Lommen, Hieronymus W. H. van Hees, Leo Heunks, Chris Dickhoff, Donald L. van der Peet, Armand R. J. Girbes, Jeff R. Jasper, Fady I. Malik, Ger J.M. Stienen, Koen J. Hartemink, Marinus A. Paul, Coen A. C. Ottenheijm,
... reductions in the CSA of diaphragm fibers in braindead organ donors (8, 13). Thus, the diaphragm muscle ...
Tópico(s): Cardiac Arrest and Resuscitation
2014 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Johann Pratschke, Markus J. Wilhelm, I. Laskowski, Mamoru Kusaka, Francisca Beato, Stefan G. Tullius, P. Neuhaus, Wayne W. Hancock, Nicholas L. Tilney,
... Groups included both allografts and isografts from normotensive braindead donors and anesthetized LD. Renal function was determined ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2001 - American Society of Nephrology | Journal of the American Society of Nephrology
Ingvar Frid, Ingegerd Bergbom, H. Haljamäe,
The aim of this narrative study was to illuminate the meaning of being a relative of a patient diagnosed as brain dead. This has so far been explored only to a limited extent. By phenomenological–hermeneutic analysis of 14 narratives, a chronological narrative in 4 steps was identified: the disquieting event; the uncertain vigil; the arduous struggle; and the difficult road ahead. From the analysis, the metaphor of an inner journey emerged, starting from a life situation taken for granted and experienced ...
Tópico(s): Family and Patient Care in Intensive Care Units
2001 - Elsevier BV | Intensive and Critical Care Nursing
... strong sanctity of life views. When hospitals treat braindead pregnant women, as in Marlise Mu˜ noz’s ...
Tópico(s): Ethics in medical practice
2015 - University of Michigan Law School | University of Michigan Journal of Law Reform
Nico Rijkhoff, Hessel Wijkstra, P.E.V. Van Kerrebroeck, F.M.J. Debruyne,
... in paraplegics compared with the synergia in a braindead human by using the single-fibre action potential ...
Tópico(s): Urological Disorders and Treatments
1997 - Lippincott Williams & Wilkins | The Journal of Urology
Luan‐Yin Chang, Tzou‐Yien Lin, Kuang‐Hung Hsu, Yhu‐Chering Huang, Kuang-Lin Lin, Chuen Hsueh, Shin‐Ru Shih, Hsiao-Chen Ning, Mao-Sheng Hwang, Huei-Shyoung Wang, Chin‐Yun Lee,
... within 12 h of intubation; one child was braindead within 15 h and died 17 days after ...
Tópico(s): RNA and protein synthesis mechanisms
1999 - Elsevier BV | The Lancet
Steven Tsui, Mariano Feccia, Pat Ongcharit, Stephen Large, K. McNeil, J. Wallwork,
Tópico(s): Renal Transplantation Outcomes and Treatments
1999 - Elsevier BV | The Journal of Heart and Lung Transplantation
Thomas Wallach, Martin Raden, Lukas Hinkelmann, Mariam Brehm, Dominik Rabsch, Hannah Weidling, Christina Krüger, Helmut Kettenmann, Rolf Backofen, Seija Lehnardt,
... the brain Methods Employing the machine learning approach BrainDead we systematically screened for SARS-CoV-2 genome- ...
Tópico(s): COVID-19 Clinical Research Studies
2023 - Frontiers Media | Frontiers in Immunology
Marc Pretze, Prama Pallavi, Mareike Roscher, Sarah Klotz, Julio Caballero, Uta Binzen, Wolfgang Greffrath, Rolf‐Detlef Treede, Martin C. Harmsen, Mathias Hafner, Benito A. Yard, Carmen Wängler, Björn Wängler,
... as it does not affect hemodynamic parameters in braindead (BD) donors. To better assess optimal NOD concentrations ...
Tópico(s): Fluorine in Organic Chemistry
2016 - American Chemical Society | Journal of Medicinal Chemistry
Ömer Özkan, Özlenen Özkan, Nasuh Utku Doğan,
... the donor was a 37-year-old multiparous braindead woman due to intracranial bleeding. After the transplant ...
Tópico(s): Reconstructive Surgery and Microvascular Techniques
2023 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Ryan L. Hoiland, Donald Griesdale, Mypinder S. Sekhon,
... values of rSO2 have been shown in neurologically braindead patients with absent CBF4Cardim D. Griesdale D.E. ...
Tópico(s): Heart Rate Variability and Autonomic Control
2020 - Elsevier BV | Resuscitation
... with a re-legitimisation of NATO. Criticised as 'braindead' by president Macron or as 'obsolete' by Trump ...
Tópico(s): Economic Sanctions and International Relations
2023 - Wiley | JCMS Journal of Common Market Studies
Striking arm movements are described in five braindead patients. The arms flex quickly to the chest from the patient9s side, the shoulders adduct, and in some patients, the hands cross or ...
Tópico(s): Psychosomatic Disorders and Their Treatments
1984 - Lippincott Williams & Wilkins | Neurology
... woman, Pamela Stewart Monson, whose baby was born braindead after she ignored her doctor's warnings about ...
Tópico(s): Grief, Bereavement, and Mental Health
1989 - University of Utah Press | The Western Political Quarterly
... I also addressed Jahi McMath, who was declared braindead, but ancillary tests, performed 9 months after initial ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2022 - Medknow | Neurology India
C Zapletal, D Faust, C. Wullstein, Guido Woeste, W. F. Caspary, M. Golling, Wolf O. Bechstein,
... in adult recipients were performed with grafts from braindead donors. Immunosuppression consisted of dual- or triple therapy ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2004 - Wolters Kluwer | Transplantation
Iori Kisu, Kouji Banno, Makoto Mihara, Nobuhiko Suganuma, Daisuke Aoki,
... was a patient aged 22 years who was braindead due to a traffic accident and the recipient ...
Tópico(s): Organ Donation and Transplantation
2013 - Karger Publishers | Gynecologic and Obstetric Investigation
Fleur C. Mokken, C. P. Henny, Mohan Kedaria, Adrian W. Gelb,
Abstract Successful transplantation of donor organs from braindead patients requires adequate maintenance of hemodynamic parameters. Blood flow and tissue perfusion are highly dependent upon hemorrheology. The aim of the present study ... and erythrocyte aggregation were obtained in ten consecutive braindead patients and ten matched volunteers. Compared to controls, ...
Tópico(s): Neurological and metabolic disorders
1995 - Springer Science+Business Media | Transplant International