Álvaro Cobo‐Calvo, Carmen Tur, Susana Otero‐Romero, Pere Carbonell‐Mirabent, Mariano Ruíz, Agustín Pappolla, Javier Villacieros Alvarez, Ángela Vidal‐Jordana, Georgina Arrambide, Joaquín Castilló, Ingrid Galán, Marta Rodríguez Barranco, Luciana Soledad Midaglia, Carlos Nos, Breogán Rodrı́guez‐Acevedo, Ana Zabalza, Neus Mongay‐Ochoa, Jordi Río, Manuel Comabella, Cristina Auger, Jaume Sastre‐Garriga, Àlex Rovira, Mar Tintoré, Xavier Montalbán,
Early treatment is associated with better long-term outcomes in patients with a first demyelinating event and early multiple sclerosis (MS). However, magnetic resonance (MR) findings are not usually integrated to construct propensity scores (PSs) when evaluating outcomes. We assessed the association of receiving very early treatment with the risk of long-term disability including an MR score (MRS) in patients with a first demyelinating event.
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2023 - Lippincott Williams & Wilkins | Neurology
Ana Zabalza, Georgina Arrambide, Susana Otero‐Romero, Agustín Pappolla, Paula Tagliani, Samuel López‐Maza, Simón Cárdenas‐Robledo, Juliana Esperalba, Candela Fernández‐Naval, Mónica Martínez‐Gallo, Mireia Castillo, Mercè Bonastre, M. Resina-Salles, Jordina Bertran, Marta Rodríguez‐Barranco, Pere Carbonell‐Mirabent, Marina González, Miguel Á. Merchán, Ana Quiroga‐Varela, Albert Miguela, Imma Gómez, Gary Álvarez, René Carlos Calderón Robles, Dúnia Pérez del Campo, Xavier Queralt, María José Soler, Irene Agraz, Fernando Martínez‐Valle, Breogán Rodrı́guez‐Acevedo, Luciana Midaglia, Ángela Vidal‐Jordana, Álvaro Cobo‐Calvo, Carmen Tur, Ingrid Galán, Joaquín Castilló, Jordi Río, Carmen Espejo, Manuel Comabella, Carlos Nos, Jaume Sastre‐Garriga, Lluís Ramió‐Torrentà, Mar Tintoré, Xavier Montalbán,
The effect of disease-modifying therapies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine response is unclear.We aim to determine the immunological responses to SARS-CoV-2 in multiple sclerosis (MS) and anti-CD20-treated patients with other autoimmune diseases (AID).Humoral and cellular responses we determined before and 30-90 days after vaccination in patients with MS and anti-CD20-treated patients with other AID in two Catalan centers.457 patients were enrolled. Findings showed ...
Tópico(s): Immunotherapy and Immune Responses
2022 - SAGE Publishing | Multiple Sclerosis Journal
Carmen Tur, Pere Carbonell‐Mirabent, Álvaro Cobo‐Calvo, Susana Otero‐Romero, Georgina Arrambide, Luciana Midaglia, Joaquín Castilló, Ángela Vidal‐Jordana, Breogán Rodrı́guez‐Acevedo, Ana Zabalza, Ingrid Galán, Carlos Nos, Annalaura Salerno, Cristina Auger, Deborah Pareto, Manuel Comabella, Jordi Río, Jaume Sastre‐Garriga, Àlex Rovira, Mar Tintoré, Xavier Montalbán,
Progression independent of relapse activity (PIRA) is the main event responsible for irreversible disability accumulation in relapsing multiple sclerosis (MS).To investigate clinical and neuroimaging predictors of PIRA at the time of the first demyelinating attack and factors associated with long-term clinical outcomes of people who present with PIRA.This cohort study, conducted from January 1, 1994, to July 31, 2021, included patients with a first demyelinating attack from multiple sclerosis; patients ...
Tópico(s): Peripheral Neuropathies and Disorders
2022 - American Medical Association | JAMA Neurology
Johnathan M. Bulled, Joseph A. M. Paddison, Andrew Wildes, E. Lhotel, Simon J. Cassidy, Breogán Pato‐Doldán, L. C. Gómez-Aguirre, Paul J. Saines, Andrew L. Goodwin,
In the dense metal-organic framework Na[Mn(HCOO)_{3}], Mn^{2+} ions (S=5/2) occupy the nodes of a "trillium" net. We show that the system is strongly magnetically frustrated: the Néel transition is suppressed well below the characteristic magnetic interaction strength; short-range magnetic order persists far above the Néel temperature; and the magnetic susceptibility exhibits a pseudo-plateau at 1/3-saturation magnetization. A simple model of nearest-neighbor Heisenberg antiferromagnetic and dipolar ...
Tópico(s): Theoretical and Computational Physics
2022 - American Physical Society | Physical Review Letters
Georgina Arrambide, Carmen Espejo, Pere Carbonell‐Mirabent, Romina Dieli-Crimi, Marta Rodríguez‐Barranco, Mireia Castillo, Cristina Auger, Simón Cárdenas‐Robledo, Joaquín Castilló, Álvaro Cobo‐Calvo, Ingrid Galán, Luciana Midaglia, Carlos Nos, Susana Otero‐Romero, Jordi Río, Breogán Rodrı́guez‐Acevedo, Mariano Ruiz-Ortiz, Annalaura Salerno, Paula Tagliani, Carmen Tur, Ángela Vidal‐Jordana, Ana Zabalza, Jaume Sastre‐Garriga, Àlex Rovira, Manuel Comabella, M. Hernández, Xavier Montalbán, Mar Tintoré,
Intrathecal production of kappa free light chains occurs in multiple sclerosis and can be measured using the kappa free light chain index. Kappa free light chain index values can be determined more easily than oligoclonal bands detection and seem more sensitive than the immunoglobulin (Ig)G index to diagnose multiple sclerosis. We assessed the value of oligoclonal bands, kappa free light chain index cut-offs 5.9, 6.6 and 10.61, and IgG index to diagnose multiple sclerosis with prospectively acquired ...
Tópico(s): Peripheral Neuropathies and Disorders
2022 - Oxford University Press | Brain
Ana Zabalza, Georgina Arrambide, Paula Tagliani, Simón Cárdenas‐Robledo, Susana Otero‐Romero, Juliana Esperalba, Candela Fernández‐Naval, Jesus Trocoli Campuzano, Mónica Martínez‐Gallo, Mireia Castillo, Mercè Bonastre, Mireia Resina Sallés, Jordina Beltran, Pere Carbonell‐Mirabent, Marta Rodríguez‐Barranco, Samuel López‐Maza, Pedro José Melgarejo Otálora, Mariano Ruiz-Ortiz, Agustín Pappolla, Breogán Rodrı́guez‐Acevedo, Luciana Midaglia, Ángela Vidal‐Jordana, Álvaro Cobo‐Calvo, Carmen Tur, Ingrid Galán, Joaquín Castilló, Jordi Río, Carmen Espejo, Manuel Comabella, Carlos Nos, Jaume Sastre‐Garriga, Mar Tintoré, Xavier Montalbán,
Information about humoral and cellular responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and antibody persistence in convalescent (COVID-19) patients with multiple sclerosis (PwMS) is scarce. The objectives of this study were to investigate factors influencing humoral and cellular responses to SARS-CoV-2 and its persistence in convalescent COVID-19 PwMS.This is a retrospective study of confirmed COVID-19 convalescent PwMS identified between February 2020 and May 2021 by SARS- ...
Tópico(s): Peripheral Neuropathies and Disorders
2022 - Wolters Kluwer | Neurology Neuroimmunology & Neuroinflammation
Ángela Vidal‐Jordana, Àlex Rovira, Georgina Arrambide, Susana Otero‐Romero, Jordi Río, Manuel Comabella, Carlos Nos, Joaquín Castilló, Ingrid Galán, Sergio Cabello, Dulce Moncho, Kimia Rahnama, Vanessa Thonon, Breogán Rodrı́guez‐Acevedo, Ana Zabalza, Luciana Midaglia, Cristina Auger, Jaume Sastre‐Garriga, Xavier Montalbán, Mar Tintoré,
To assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria.From the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and dissemination in time at baseline (n = 388) were selected. Modified DIS (modDIS) criteria were constructed by adding the optic nerve to the current DIS regions. The DIS and modDIS criteria were evaluated with univariable ...
Tópico(s): Systemic Lupus Erythematosus Research
2021 - Lippincott Williams & Wilkins | Neurology
Mar Tintoré, Álvaro Cobo‐Calvo, Pere Carbonell, Georgina Arrambide, Susana Otero‐Romero, Jordi Río, Carmen Tur, Manuel Comabella, Carlos Nos, María Jesús Arévalo, Luciana Midaglia, Ingrid Galán, Ángela Vidal‐Jordana, Joaquín Castilló, Breogán Rodrı́guez‐Acevedo, Ana Zabalza, Annalaura Salerno, Cristina Auger, Jaume Sastre‐Garriga, Àlex Rovira, Xavier Montalbán,
To explore whether time to diagnosis, time to treatment initiation, and age to reach disability milestones have changed in patients with clinically isolated syndrome (CIS) according to different multiple sclerosis (MS) diagnostic criteria periods.This retrospective study was based on data collected prospectively from the Barcelona-CIS cohort between 1994 and 2020. Patients were classified into 5 periods according to different MS criteria, and the times to MS diagnosis and treatment initiation were ...
Tópico(s): Multiple Sclerosis Research Studies
2021 - Lippincott Williams & Wilkins | Neurology
Susana Otero‐Romero, Luciana Midaglia, Pere Carbonell‐Mirabent, María Isabel Zuluaga Rodas, Ingrid Galán, Jordi Río, Georgina Arrambide, Marta Rodríguez‐Barranco, Ángela Vidal‐Jordana, Joaquín Castilló, Breogán Rodrı́guez‐Acevedo, Ana Zabalza, Carlos Nos, Manuel Comabella-López, Patricia Mulero, Cristina Auger, Jaume Sastre‐Garriga, Santiago Pérez‐Hoyos, Àlex Rovira, Xavier Montalbán, Mar Tintoré,
To evaluate the effect of menopause on disability accumulation in women followed from their clinically isolated syndrome (CIS).We examined the longitudinal changes in Expanded Disability Status Scale (EDSS) scores from CIS until the last follow-up in women belonging to the Barcelona CIS prospective cohort, followed through their menopausal transition. The analysis is based on 13,718 EDSS measurements, with an average of 28 EDSS measurements per patient. Differences in EDSS trajectories between menopausal ...
Tópico(s): Multiple Sclerosis Research Studies
2021 - Wiley | European Journal of Neurology
Luciana Midaglia, Jaume Sastre‐Garriga, Agustín Pappolla, Laura Quibus, René Carvajal, Ángela Vidal‐Jordana, Georgina Arrambide, Jordi Río, Manuel Comabella, Carlos Nos, Joaquín Castilló, Ingrid Galán, Breogán Rodrı́guez‐Acevedo, Cristina Auger, Mar Tintoré, Xavier Montalbán, Àlex Rovira,
Background: Multiple sclerosis (MS) misdiagnosis may cause physical and emotional damage to patients. Objectives: The objective of this study is to determine the frequency and characteristics of MS misdiagnosis in patients referred to the Multiple Sclerosis Centre of Catalonia. Methods: We designed a prospective study including all new consecutive patients referred to our centre between July 2017 and June 2018. Instances of misdiagnosis were identified, and referral diagnosis and final diagnosis ...
Tópico(s): Polyomavirus and related diseases
2021 - SAGE Publishing | Multiple Sclerosis Journal
Manuela Gago‐Dominguez, Marcos Matabuena, Carmen M. Redondo, Sandip Pravin Patel, Ãngel Carracedo, Sara Miranda Ponte, Marı́a Elena Martı́nez, Jose E. Castelao,
... role of NLR and risk of BC. The BREOGAN study is a population-based case–control study ...
Tópico(s): Cancer Risks and Factors
2020 - Nature Portfolio | Scientific Reports
Breogán Gómez, C. L. Charlton-Perez, Huw Lewis, Brett Candy,
In this study, the current Met Office operational land surface data assimilation system used to produce soil moisture analyses is presented. The main aim of including Land Surface Data Assimilation (LSDA) in both the global and regional systems is to improve forecasts of surface air temperature and humidity. Results from trials assimilating pseudo-observations of 1.5 m air temperature and specific humidity and satellite-derived soil wetness (ASCAT) observations are analysed. The pre-processing of ...
Tópico(s): Cryospheric studies and observations
2020 - Multidisciplinary Digital Publishing Institute | Remote Sensing
Ana Zabalza, Simón Cárdenas‐Robledo, Paula Tagliani, Georgina Arrambide, Susana Otero‐Romero, Pere Carbonell‐Mirabent, Marta Rodríguez‐Barranco, Breogán Rodrı́guez‐Acevedo, Juan Luis Restrepo‐Vera, M. Resina-Salles, Luciana Midaglia, Ángela Vidal‐Jordana, Jordi Río, Ingrid Galán, Joaquín Castilló, Álvaro Cobo‐Calvo, Manuel Comabella, Carlos Nos, Jaume Sastre‐Garriga, Mar Tintoré, Xavier Montalbán,
Abstract Background and purpose Information regarding multiple sclerosis (MS) patients with the 2019 novel coronavirus disease (COVID‐19) is scarce. The study objective was to describe the incidence and characteristics of MS patients with COVID‐19, to identify susceptibility and severity risk factors and to assess the proportion of positive severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) serologies according to disease‐modifying treatments. Methods This was a retrospective study of an ...
Tópico(s): Peripheral Neuropathies and Disorders
2020 - Wiley | European Journal of Neurology
José Medina‐Polo, J.M. Adot, Marta Allué, Salvador Arlandis, Pedro Blasco, Bonaventura Casanova, Jorge Matías‐Guiu, Blanca Madurga, E. R. Meza Murillo, Carlos Müller‐Arteaga, Breogán Rodrı́guez‐Acevedo, Jesús Vara, María Carmen Zubiaur, Luis López‐Fando,
Abstract Aim Neurogenic lower urinary tract dysfunction (NLUTD) is very common in multiple sclerosis (MS) patients. Early diagnosis and treatment are crucial to avoid irreversible damage and improve quality of life. Our aim was to develop recommendations to improve NLUTD identification in MS patients, along with their referral and management. Methods A multidisciplinary group of 14 experts in the management of patients with MS and NLUTD (nine urologists, three neurologists, and two rehabilitators) ...
Tópico(s): Urinary Bladder and Prostate Research
2020 - Wiley | Neurourology and Urodynamics
David Nieto‐Castro, Felipe A. Garcés‐Pineda, Andrea Moneo‐Corcuera, Breogán Pato‐Doldán, Francesc Gispert‐Guirado, J. Benet‐Buchholz, José Ramón Galán‐Mascarós,
The thermal hysteresis in the cooperative spin crossover (SCO) polymer [Fe(trz)(Htrz)2]n[BF4]n (1) has been tuned by a simple ball milling grinding process. Mechanical treatment affects the size and morphology of the crystallite domains, as confirmed by multiple complementary techniques, including ESEM, DLS, and PXRD data. Upon milling, the regular cubic shape particles recrystallize with slightly different unit cell parameters and preferential orientation. This macroscopic change significantly modifies ...
Tópico(s): Lanthanide and Transition Metal Complexes
2020 - American Chemical Society | Inorganic Chemistry
Mali H. Rosnes, Breogán Pato‐Doldán, Rune E. Johnsen, Alexander Mundstock, Jürgen Caro, Pascal D. C. Dıetzel,
The dehydration of the CPO-27-M (M-MOF-74, M = Zn, Co, Ni, Mg, Mn, Cu) metal-organic framework series has been investigated comprehensively using in situ variable temperature powder X-ray diffraction (VT-PXRD) and thermal analysis (TG) coupled with mass spectrometry (MS). Significant differences in the order of water desorption from different adsorption sites on heating are found with varying metal cation in the otherwise isostructural material. For all CPO-27-M (except M = Cu), water is bonded significantly ...
Tópico(s): Enhanced Oil Recovery Techniques
2020 - Elsevier BV | Microporous and Mesoporous Materials
Mar Tintoré, Georgina Arrambide, Susana Otero‐Romero, Pere Carbonell‐Mirabent, Jordi Río, Carmen Tur, Manuel Comabella, Carlos Nos, María Jesús Arévalo, Elisenda Anglada, Rebeca Menéndez, Luciana Midaglia, Ingrid Galán, Ángela Vidal‐Jordana, Joaquín Castilló, Patricia Mulero, Ana Zabalza, Breogán Rodrı́guez‐Acevedo, Marta Rodríguez, Carmen Espejo, J. Sequeira, Raquel Mitjana, Andréa de Barros, Deborah Pareto, Cristina Auger, Santiago Pérez‐Hoyos, Jaume Sastre‐Garriga, Àlex Rovira, Xavier Montalbán,
To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort.We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6.0 at 10 years).In ...
Tópico(s): Systemic Sclerosis and Related Diseases
2019 - SAGE Publishing | Multiple Sclerosis Journal
María Isabel Zuluaga Rodas, Susana Otero‐Romero, Àlex Rovira, Santiago Pérez‐Hoyos, Georgina Arrambide, Laura Negrotto, Ingrid Galán, Jordi Río, Manuel Comabella, Carlos Nos, María Jesús Arévalo, Ángela Vidal‐Jordana, Joaquín Castilló, Breogán Rodrı́guez‐Acevedo, Luciana Midaglia, Patricia Mulero, Raquel Mitjana, Cristina Auger, Jaume Sastre‐Garriga, Xavier Montalbán, Mar Tintoré,
To investigate the effect of menarche, pregnancies, and breastfeeding on the risk of developing multiple sclerosis (MS) and disability accrual using a multivariate approach based on a large prospective cohort of patients with clinically isolated syndrome (CIS).A cross-sectional survey of the reproductive information of female participants in a CIS cohort was performed. We examined the relationship of age at menarche with the risk of clinically definite MS (CDMS), McDonald 2010 MS, and Expanded Disability ...
Tópico(s): Dermatology and Skin Diseases
2019 - Lippincott Williams & Wilkins | Neurology
Georgina Arrambide, Mar Tintoré, Carmen Espejo, Cristina Auger, Mireia Castillo, Jordi Río, Joaquín Castilló, Ángela Vidal‐Jordana, Ingrid Galán, Carlos Nos, Raquel Mitjana, Patricia Mulero, Andréa de Barros, Breogán Rodrı́guez‐Acevedo, Luciana Midaglia, Jaume Sastre‐Garriga, Àlex Rovira, Manuel Comabella, Xavier Montalbán,
The presence of oligoclonal bands in clinically isolated syndromes is an independent risk factor for developing multiple sclerosis and has been largely excluded from the more recent multiple sclerosis diagnostic criteria. Therefore, our objective was to explore the value of oligoclonal bands in the context of the 2010 McDonald criteria, especially in patients fulfilling exclusively dissemination in space at baseline. For this purpose, we selected 566 patients from a clinically isolated syndrome ...
Tópico(s): Peripheral Neuropathies and Disorders
2018 - Oxford University Press | Brain
Sujay V. Kumar, Jiarui Dong, C. D. Peters‐Lidard, David M. Mocko, Breogán Gómez,
Abstract. Accurate specification of the model error covariances in data assimilation systems is a challenging issue. Ensemble land data assimilation methods rely on stochastic perturbations of input forcing and model prognostic fields for developing representations of input model error covariances. This article examines the limitations of using a single forcing dataset for specifying forcing uncertainty inputs for assimilating snow depth retrievals. Using an idealized data assimilation experiment, ...
Tópico(s): Climate variability and models
2017 - Copernicus Publications | Hydrology and earth system sciences
Breogán Pato‐Doldán, Mali H. Rosnes, Pascal D. C. Dıetzel,
Abstract The CO 2 adsorption process in the family of porous metal–organic framework materials CPO‐27‐M (M=Mg, Mn, Co, Ni, Cu, and Zn) was studied by variable‐temperature powder synchrotron X‐ray diffraction under isobaric conditions. The Rietveld analysis of the data provided a time‐lapse view of the adsorption process on CPO‐27‐M. The results confirm the temperature‐dependent order of occupation of the three adsorption sites in the pores of the CPO‐27‐M materials. In CPO‐27‐M (M=Mg, Mn, Co, Ni, ...
Tópico(s): Carbon Dioxide Capture Technologies
2017 - Wiley | ChemSusChem
Georgina Arrambide, Mar Tintoré, Cristina Auger, Jordi Río, Joaquín Castilló, Ángela Vidal‐Jordana, Ingrid Galán, Carlos Nos, Manuel Comabella, Raquel Mitjana, Patricia Mulero, Andréa de Barros, Breogán Rodrı́guez‐Acevedo, Luciana Midaglia, Jaume Sastre‐Garriga, Àlex Rovira, Xavier Montalbán,
To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions in clinically isolated syndromes (CIS).Step 1: We evaluated lesion topography classifications in 657 patients with CIS with stepwise Cox proportional hazards regression models considering second attack as the outcome. Step 2: We established 2 dissemination in space (DIS) versions according to the periventricular lesion cutoffs of ≥ ...
Tópico(s): Systemic Lupus Erythematosus Research
2017 - Lippincott Williams & Wilkins | Neurology
Georgina Arrambide, Àlex Rovira, Jaume Sastre‐Garriga, Carmen Tur, Joaquín Castilló, Jordi Río, Ángela Vidal‐Jordana, Ingrid Galán, Breogán Rodrı́guez‐Acevedo, Luciana Midaglia, Carlos Nos, Patricia Mulero, María Jesús Arévalo, Manuel Comabella, Elena Charro Huerga, Cristina Auger, Xavier Montalbán, Mar Tintoré,
Background: The usefulness of performing a spinal cord (SC) magnetic resonance imaging (MRI) in all clinically isolated syndromes (CIS) is controversial. Objective: To assess the value of SC lesions for predicting multiple sclerosis (MS) diagnosis and disability accrual in CIS. Methods: Concerning SC lesions and MS diagnosis (2010 McDonald), adjusted Cox regression analyses were performed in increasingly specific CIS groups: all cases ( n = 207), non-SC CIS ( n = 143), non-SC CIS with abnormal brain MRI ( n = 90) ...
Tópico(s): Bone and Joint Diseases
2017 - SAGE Publishing | Multiple Sclerosis Journal
Breogán Gómez, Gonzalo Miguez‐Macho,
Numerous studies have been presented describing the benefits of using Nudging to constrain the evolution of a numerical model. Recently, a variation of this approach called Spectral Nudging has gained popularity for its ability to maintain the higher temporal and spatial variability of the model results, while forcing the large scales in the solution with a coarser‐resolution field. Here, we focus on a not‐much‐explored aspect of this technique: the impact of selecting different cut‐off wave numbers ...
Tópico(s): Tropical and Extratropical Cyclones Research
2017 - Wiley | Quarterly Journal of the Royal Meteorological Society
Breogán Pato‐Doldán, L. C. Gómez-Aguirre, Anders Hansen, J. Mira, Socorro Castro‐García, Manuel Sánchez‐Andújar, M. A. Señarís‐Rodríguez, Vivien S. Zapf, John Singleton,
We show unconventional magnetic features of the [CH 3 NH 3 ][M(HCOO) 3 ] perovskite-like family such as the isotropic/anisotropic response unmasked by high magnetic fields.
Tópico(s): Advanced Condensed Matter Physics
2016 - Royal Society of Chemistry | Journal of Materials Chemistry C
Mar Tintoré, Susana Otero‐Romero, Jordi Río, Georgina Arrambide, Berta Pujal, Carmen Tur, Ingrid Galán, Manuel Comabella, Carlos Nos, María Jesús Arévalo, Ángela Vidal‐Jordana, Joaquín Castilló, Breogán Rodrı́guez‐Acevedo, Luciana Midaglia, Raquel Mitjana, Cristina Auger, Jaume Sastre‐Garriga, Àlex Rovira, Xavier Montalbán,
To study the contribution of the symptomatic lesion in establishing multiple sclerosis (MS) diagnosis and prognosis.We performed an observational study based on a prospective clinically isolated syndrome (CIS) cohort of 1,107 patients recruited for clinical and brain MRI follow-up from 1995 to 2014. Eligible patients (n = 954) were divided into 4 groups according to baseline MRI: patients with a normal MRI (n = 290); patients with a single asymptomatic lesion (n = 18); patients with a single cord/brainstem ...
Tópico(s): Lymphadenopathy Diagnosis and Analysis
2016 - Lippincott Williams & Wilkins | Neurology
L. C. Gómez-Aguirre, Breogán Pato‐Doldán, Alessandro Stroppa, Li‐Ming Yang, Thomas Frauenheim, J. Mira, S. Yáñez‐Vilar, Ramón Artiaga, Socorro Castro‐García, Manuel Sánchez‐Andújar, M. A. Señarís‐Rodríguez,
Abstract The perovskite azido compound [(CH 3 ) 4 N][Mn(N 3 ) 3 ], which undergoes a first‐order phase change at T t =310 K with an associated magnetic bistability, was revisited in the search for additional ferroic orders. The driving force for such structural transition is multifold and involves a peculiar cooperative rotation of the [MnN 6 ] octahedral as well as order/disorder and off‐center shifts of the [(CH 3 ) 4 N] + cations and bridging azide ligands, which also bend and change their coordination mode. According ...
Tópico(s): Solid-state spectroscopy and crystallography
2016 - Wiley | Chemistry - A European Journal
L. C. Gómez-Aguirre, Breogán Pato‐Doldán, Alessandro Stroppa, S. Yáñez‐Vilar, Lkhamsuren Bayarjargal, B. Winkler, Socorro Castro‐García, J. Mira, Manuel Sánchez‐Andújar, M. A. Señarís‐Rodríguez,
We report on the hybrid inorganic–organic ammonium compound [NH4][Cd(HCOO)3], which displays a most unusual framework structure: instead of the expected 49·66 topology, it shows an ABX3 perovskite architecture with the peculiarity and uniqueness (among all the up-to-date reported hybrid metal formates) that the Cd ions are connected only by syn–anti formate bridges, instead of anti–anti ones. This change of the coordination mode of the formate ligand is thus another variable that can provide new possibilities ...
Tópico(s): Solid-state spectroscopy and crystallography
2015 - American Chemical Society | Inorganic Chemistry
L. C. Gómez-Aguirre, Breogán Pato‐Doldán, J. Mira, Socorro Castro‐García, M. A. Señarís‐Rodríguez, Manuel Sánchez‐Andújar, John Singleton, Vivien S. Zapf,
We present the first example of magnetic ordering-induced multiferroic behavior in a metal–organic framework magnet. This compound is [CH3NH3][Co(HCOO)3] with a perovskite-like structure. The A-site [CH3NH3]+ cation strongly distorts the framework, allowing anisotropic magnetic and electric behavior and coupling between them to occur. This material is a spin canted antiferromagnet below 15.9 K with a weak ferromagnetic component attributable to Dzyaloshinskii–Moriya (DM) interactions and experiences ...
Tópico(s): Crystal Structures and Properties
2015 - American Chemical Society | Journal of the American Chemical Society
Manuel Sánchez‐Andújar, L. C. Gómez-Aguirre, Breogán Pato‐Doldán, S. Yáñez‐Vilar, Ramón Artiaga, A.L. Llamas-Saiz, R.S. Manna, F. Schnelle, Michael Lang, Franz Ritter, Amir A. Haghighirad, M. A. Señarís‐Rodríguez,
In this work we explore the overall structural behaviour of the [(CH3)2NH2][Mn(HCOO)3] multiferroic compound across the temperature range where its ferroelectric transition takes place by means of calorimetry, thermal expansion measurements and variable temperature powder and single crystal X-ray diffraction. The results clearly prove the presence of a structural phase transition at Tt ~ 187 K (the temperature at which the dielectric transition occurs) that involves a symmetry change from Rc to Cc, twinning ...
Tópico(s): Perovskite Materials and Applications
2014 - Royal Society of Chemistry | CrystEngComm