Hermann R. Ochs, David J. Greenblatt, H. Friedman, Ethan S. Burstein, Ann Locniskar, Jerold S. Harmatz, Richard I. Shader,
Pharmacokinetics of the benzodiazepine bromazepam were evaluated in volunteer subjects who received single 6 mg oral doses followed by blood sampling during the next 48 ... subjects, the elderly had significantly higher peak serum bromazepam concentrations (132 vs. 82 ng/ml), smaller volume ... unbound). However, gender had no significant influence on bromazepam kinetics. In 11 young female users of oral ... women not using oral contraceptives, no differences in bromazepam kinetics were observed. Coadministration of cimetidine (1.2 ...
Tópico(s): Anesthesia and Sedative Agents
1987 - Wiley | Clinical Pharmacology & Therapeutics
... spectrofluorimetric method for determination of trace amount of bromazepam is developed. In phosphate buffer of pH 7.4. The bromazepam enhance the luminescence intensity of the Eu3+ ion in Eu3+–bromazepam complex at λex = 390 nm. The produced luminescence intensity of Eu3+–bromazepam complex is in proportion to the concentration of bromazepam. The working range for the determination of bromazepam is 2.3 × 10−8 to 6.2 × ... mechanism of the luminescence intensity in the Eu3+–bromazepam system has been also explained.
Tópico(s): Electrochemical sensors and biosensors
2009 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Yasukiyo Ohtani, Tsutomu Kotegawa, Kimiko Tsutsumi, Takuya Morimoto, Yumiko Hirose, Shigeyuki Nakano,
... more traditional approaches to an interaction study of bromazepam and fluconazole. Twelve healthy male volunteers participated in ... subjects received single oral or rectal doses of bromazepam (3 mg) after 4‐day pretreatment of oral fluconazole (100 mg daily) or its placebo. Plasma bromazepam concentrations were measured before and 0.5, 1, ... 6,12,22,46, and 70 hours after bromazepam administration. Pharmacodynamic effects of bromazepam were assessed using self‐rated drowsiness, continuous number ... in pharmacokinetics and pharmacodynamics of oral or rectal bromazepam. Rectal administration significantly increased AUC (1.7‐fold, ...
Tópico(s): Anesthesia and Sedative Agents
2002 - Wiley | The Journal of Clinical Pharmacology
Marion Villain, Marjorie Chèze, V. Dumestre, Bertrand Ludes, Pascal Kintz,
... explore the detectability of a single absorption of bromazepam in hair, two volunteers (male and female) received ... 1 to 154.1 and 198.2 for bromazepam and the IS, respectively. In the hair of the two subjects, bromazepam was detected in the proximal segment at 0. ... authentic criminal cases. In the two first cases, bromazepam tested positive in the corresponding hair segment at ... corresponding period. However, 4.1 pg/mg of bromazepam was quantified in the victim's pubic hair. ... concentrations were consistent with a single exposure to bromazepam. In the last case, bromazepam was detected at ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2004 - Oxford University Press | Journal of Analytical Toxicology
Luciano Antolini, Giuseppe Brunò, Matteo Cusumano, Antonino Giannetto, P Ficarra, R Ficarra,
... 2-pyridyl)-2H-1,4-benzodiazepine-2-one (bromazepam) coordinated with the two α-diimine nitrogen atoms of bromazepam and two cis-chlorine atoms. The geometry of ... II) complex, where the usual boat conformation of bromazepam is retained. The kinetics of displacement of coordinated bromazepam, by 1,10-phenanthroline and 2,2′-bipyridine, in [Pd(bromazepam)Cl2] have been studied by stopped-flow spectrophotometry ... complex and a solvo-species with mono-coordinated bromazepam. In the case of the less reactive bipyridine, ...
Tópico(s): Inorganic and Organometallic Chemistry
1992 - Elsevier BV | Polyhedron
Samir F Saad, Azza M. Agha, Abd el-naser S. Amrin,
The possible antiulcer potential of bromazepam was investigated in relation to its effect on the levels of central neurotransmitters in rats. Peptic ulcer was induced by cold- ... placed for 2 h at 4 degrees C. Bromazepam (1 and 2 mg x kg(-1), i. ... 2 mg x kg(-1)) dose regimens of bromazepam succeeded in preventing gastric ulceration, without significant effects ... almost all tested brain regions were observed in bromazepam-treated groups, as compared to the control stressed ... kg(-1)) as well as repeated administration of bromazepam. Similarly, norepinephrine (NE) concentrations were decreased in the ...
Tópico(s): Ginger and Zingiberaceae research
2001 - Elsevier BV | Pharmacological Research
Michel Bourin, J. L. Auget, Marc Colombel, C Larousse,
Three anxiolytic drugs (bromazepam 3 mg, buspirone 10 mg, and clobazam 10 mg p.o.) were evaluated for their effects on memory, psychomotor ... 01), but in the 6-hour session only bromazepam showed a significant difference (p < 0.05). The ... by subjects during DSST was significantly decreased by bromazepam and buspirone as compared to placebo (p < 0. ... or for motor response in CRT, except between bromazepam and clobazam after 6 h (p < 0.05). ... of the drugs altered performance during CFF (except bromazepam), and clobazam actually improved performance. All the drugs ...
Tópico(s): Neural and Behavioral Psychology Studies
1989 - Karger Publishers | Neuropsychobiology
Beat Aebi, R Sturny-Jungo, Wolfgang Bernhard, Robert V. Blanke, Roman Hirsch,
... mixture of three selected benzodiazepines (diazepam, nordazepam and bromazepam) were used to compare gas chromatography (GC-TOF- ... of GC-TOF-MS. Five-point calibrations for bromazepam in human peripheral blood (50, 100, 160, 200, ... scan mode. Two analyses of real cases concerning bromazepam are presented. In the first case, the presence or absence of bromazepam could not be established with both HPLC-DAD ... TOF-MS could clearly excluded the presence of bromazepam. The second case illustrates the quantitation of bromazepam, ...
Tópico(s): Analytical Methods in Pharmaceuticals
2002 - Elsevier BV | Forensic Science International
W.F. Smyth, R. A. Scannell, T.K. Goggin, D. Lucas-Hernández,
Bromazepam, in the form of a cationic iron(II) chelate, can be determined spectrophotometrically at 588 nm ... of detection of 1.5 × 10-5 M bromazepam at the iron resonance 248.3-nm line. ... c. method could also be used to quantify bromazepam spiked in plasma in the concentration range 1–10 μg ml-1, following extraction of bromazepam from plasma and subsequent formation of the iron( ... pair. Copper(II) forms a labile chelate with bromazepam in pH 4.8 acetate buffer which, when ... which can be utilised for the determination of bromazepam in the concentration range 10-5–10-9 ...
Tópico(s): Analytical chemistry methods development
1982 - Elsevier BV | Analytica Chimica Acta
Junko Fujii, Nobuo Inotsume, Masahiro Nakano,
Degradation of four benzodiazepines, i.e. bromazepam, diazepam, desmethyldiazepam, and 7-bromo-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepin-2 (1H) -one, in a broth containing human feces was studied. Degradation of bromazepam was also investigated in a fecal medium, a ... epithelial cells of rat. More than 80% of bromazepam, which contains a pyridine ring in its structure, ... and aerobic conditions. The major degradation product of bromazepam was identified as 2- (2-amino-5-bromobenzoyl) ... spectra analyses. About 70, 90, and 90% of bromazepam remained in the fecal medium, homogenate of the ...
Tópico(s): Psychedelics and Drug Studies
1987 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Marjorie Chèze, Marc Deveaux, Aurélie Lenoan, Gilbert Pépin,
... les prévalences du Zolpidem, du clonazepam et du bromazepam étaient les plus élevées, suivies par d'autres ... Zolpidem, le clonazepam (7-NH2-clonazépam) et le bromazepam, afin d'interpréter les concentrations retrouvées dans les ... 0,9997 pour le 7-NH2-clonazepam, le bromazepam et le Zolpidem, respectivement. Les LOD étaient de ... de 2,8 à 12 (n = 6) en bromazepam et de 1,2 à 19 (n = 15) ... et de 121 à 665 (n = 2) en bromazepam. Un cas de toxicomanie au Zolpidem (10-30 ... 2534 à 9197 pg/mg. Nos concentrations en bromazepam et 7-NH2-clonazépam précédemment publiées n'étaient ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2005 - Elsevier BV | Annales de Toxicologie Analytique
James P. Chovan, Jeannette Dehaas Vermeulen,
... spectrofluorimetric method for determination of trace amount of bromazepam is developed. In phosphate buffer of pH 7.4. The bromazepam enhance the luminescence intensity of the Eu3+ ion in Eu3+–bromazepam complex at λex = 390 nm. The produced luminescence intensity of Eu3+–bromazepam complex is in proportion to the concentration of bromazepam. The working range for the determination of bromazepam is 2.3 × 10−8 to 6.2 × ... mechanism of the luminescence intensity in the Eu3+–bromazepam system has been also explained.
Tópico(s): Treatment of Major Depression
1989 - Elsevier BV | Journal of Chromatography B Biomedical Sciences and Applications
Réjean Fontaine, P. Mercier, P. Beaudry, L Annable, G Chouinard,
... randomly assigned to 4 weeks of treatment with bromazepam, lorazepam or placebo, following a 1‐week placebo ... no significant difference in the anxiolytic effects of bromazepam and lorazepam, both of which were superior to ... a more depressed mood than those treated with bromazepam. Drug‐treated patients had consistently less cognitive impairment ... statistically significant ( P .05) in the case of bromazepam. The most frequent side‐effects reported with each ... positive correlation (r = 0.64) between age and bromazepam plasma concentration per unit dose, adjusted for weight, ...
Tópico(s): Neural and Behavioral Psychology Studies
1986 - Wiley | Acta Psychiatrica Scandinavica
Alaa A. Salem, B. N. Barsoum, Emad L. Izake,
... new spectrophotometric procedures for determining trace amounts of bromazepam and clonazepam, 1,4-benzodiazepine derivatives in their ... λ = 330 nm and λ = 375 nm for bromazepam and clonazepam, respectively. Linear calibration curves were obtained ... 31.6–316.0 µg mL−1 for bromazepam and of 63.2–316.0 µg mL− ... and 0.67–1.74% relative errors for bromazepam and clonazepam, respectively. The methods showed standard deviations ... 1.58% and 0.32–1.19% for bromazepam and clonazepam tablets, respectively. Student t-test and ...
Tópico(s): Anesthesia and Sedative Agents
2002 - Taylor & Francis | Analytical Letters
Produção Nacional
Revisado por pares
Marlo Cunha, Dionis Machado, Víctor Hugo Bastos, Camila Ferreira, Maurício Cagy, Luis Basile, Roberto Piedade, Pedro Ribeiro,
To investigate the effects of bromazepam on motor performance and electroencephalographic activity (qEEG) in healthy subjects, during the process of learning a typewriting task, with a focused ... one of the following conditions: placebo (n = 13), bromazepam 3 mg (n = 13) or bromazepam 6 mg (n = 13). Forty minutes after treatment ... number of typing errors was observed in both bromazepam conditions (Br 3 mg and Br 6 mg) ... placebo. There was no difference between the two bromazepam conditions. For the execution time variable, a better ...
Tópico(s): Neuroscience and Neural Engineering
2006 - Elsevier BV | Neuroscience Letters
Patrick Lemoine, Imane Kermadi, Stéphanie Garcia-Acosta, Ricardo P. Garay, Michel Dib,
... with cyamemazine (25–50 mg q.d.) or bromazepam (3–6 mg q.d.), followed by 2 ... 66.7%) and 55/84 patients in the bromazepam group (65.5%) were successfully withdrawn. 28 patients in the cyamemazine group and 18 in the bromazepam group had an adverse event, including anxiety, insomnia, ... were reported. In conclusion, cyamemazine was comparable to bromazepam in ensuring successful benzodiazepine withdrawal and in controlling ... to facilitate benzodiazepine withdrawal in those patients where bromazepam substitution is not appropriate.
Tópico(s): Memory and Neural Mechanisms
2005 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Produção Nacional
Revisado por pares
Fernanda Puga, Heloisa Veiga, Maurício Cagy, Kaleb McDowell, Roberto Piedade, Pedro Ribeiro,
... four decades. However, very few studies have combined bromazepam and event-related potentials (ERP). The present study ... drug on brain dynamics. Specifically, the effects of bromazepam (3 mg) on the P300 component of the ... three experimental conditions: placebo 1, placebo 2, and bromazepam. Results suggest that the effects of bromazepam (3 mg) on cognitive processes are not apparent. ... spite of what seems irrefutable in current literature, bromazepam did not produce evident effects on the behavioral ...
Tópico(s): Memory and Neural Mechanisms
2005 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Produção Nacional
Revisado por pares
Maristela Andraus, Anthony Wong, Ovandir A. Silva, Cicília Y. Wada, Odaly Toffleto, Cristina P. Azevedo, Myriam C. Salvadori,
... MS) detection was developed for the determination of bromazepam in human plasma, using lorazepam as internal standard. ... monitoring the transitions: m/z 316 > 182 for bromazepam and m/z 321 > 275 for lorazepam. The ... assay accuracies were 102.5 and 104%, respectively. Bromazepam stability was evaluated and the results showed that ... oral doses (6 mg) of reference and test bromazepam formulations, in an open, two-period, randomized, crossover ... reference formulation regarding the rate and extent of bromazepam absorption.
Tópico(s): Neuroscience and Neuropharmacology Research
2004 - Wiley | Journal of Mass Spectrometry
Marjorie Chèze, Marion Villain, Gilbert Pépin,
... TSQ) for the determination of single exposure to bromazepam (Lexomil®, 6 mg) and clonazepam (Rivotril®, 2 mg) ... Toxitube A® (Varian) and allowed the detection of bromazepam, 3-hydroxy-bromazepam, clonazepam and 7-Aminoclonazepam for more than 6 ... gave better recoveries and repeatability. After single exposure, bromazepam was present in powdered hair at 28 pg/ ... two forensic cases. It allowed us to determine bromazepam in urine 3 days after the alleged offense ...
Tópico(s): Psychedelics and Drug Studies
2004 - Elsevier BV | Forensic Science International
V. Hobi, U. C. Dubach, M. Skreta, J Forgo, Hans Riggenbach,
The effects of short-term (acute) doses of bromazepam were studied in a double-blind trial with ... and 1.5 mg or 3.0 mg bromazepam, respectively). Subjective well-being was recorded through self- ... terms, in the group that received 3 mg bromazepam than in either the placebo or the 1.5 mg bromazepam group. In the reaction time test and in ... Our investigation studied the single-dose schedules of bromazepam – viz. 1.5 mg and 3 mg – that ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
1981 - SAGE Publishing | Journal of International Medical Research
Produção Nacional
Revisado por pares
José Carlos Saraiva Gonçalves, Tânia Monteiro, Claúdia Silvana de Miranda Neves, Karla Regina da Silva Gram, Nádia Maria Volpato, Vivian A Silva, Ricardo Carvalho Caminha, Maria do Rocio Bencke Gonçalves, Fábio Monteiro dos Santos, Gabriel Estolano da Silveira, François Noël,
... MS-MS) is described for the quantification of bromazepam in human plasma. The method involves a dilution ... monitoring (MRM). The m/z transitions 316-->182 (bromazepam) and 237-->194 (carbamazepine) were used for quantification. ... to 200 ng/mL. The retention times of bromazepam and carbamazepine were 2.6 and 3.2 ... study of 2 tablet formulations of 6 mg bromazepam: Lexotan(R) from Produtos Roche Químicos e Farmacêuticos ... based experimental conditions for a dissolution test of bromazepam tablets, actually lacking a pharmacopeial monograph.
Tópico(s): Analytical Chemistry and Chromatography
2005 - Lippincott Williams & Wilkins | Therapeutic Drug Monitoring
Produção Nacional
Revisado por pares
Mariana Gongora, Caroline Peressuti, Bruna Velasques, Juliana Bittencourt, Silmar Teixeira, Óscar Arias-Carrión, Maurício Cagy, Pedro Ribeiro,
Bromazepam is a benzodiazepine, which has been widely employed in the treatment of anxiety. We investigated the ... cortex when individuals performed a visuomotor task under bromazepam. The sample of 17 healthy individuals was randomized into 2 experimental conditions, under which bromazepam 6 mg and placebo were administered on different ... We found an increase in reaction time under bromazepam compared with placebo . With regard to the electrophysiological ... lateral frontal region showed lower theta power under bromazepam for pre- and post-finger movement. This could ...
Tópico(s): EEG and Brain-Computer Interfaces
2014 - SAGE Publishing | Clinical EEG and Neuroscience
Bromazepam (7-bromo-1, 3-dihydro-5-(2-pyridyl)-2H-1, 4-benzodiazepin-2-one) was determined ... from 0.2 to 50 μg/ml of bromazepam and the sensitivity of the procedure was 0.2 μg/ml of bromazepam. This procedure was applied to the determination of bromazepam in rat blood. The recovery of added bromazepam from rat blood ranged from 96 to 100. ...
Tópico(s): Epilepsy research and treatment
1980 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
M Gerold, I. Cavero, Hans Riggenbach, Michael Wall, Günther Haeusler,
In conscious trained dogs, administration of bromazepam (0.3 mg/kg p.o.) or diazepam (0.3 and 1.0 mg/kg p.o.) had no influence on heart ... parasympathetic interaction cannot be excluded. However, diazepam and bromazepam significantly reduced the tachycardia which is normally observed ... or in combination with practolol. In anaesthetized dogs, bromazepam failed to modify the heart rate responses to ... is concluded that high doses of diazepam and bromazepam influence the heart rate of conscious dogs in ...
Tópico(s): Heart Rate Variability and Autonomic Control
1976 - Elsevier BV | European Journal of Pharmacology
Max Fink, Peter Irwin, Robert E. Weinfeld, Morton A. Schwartz, Allan H. Canney,
... for 2 hr after single oral doses of bromazepam (9 mg), diazepam (10 mg), and placebo in ... nglml of diazepam or 50 ng Iml of bromazepam were associated with significant changes in EEG beta ... in the EEG after administration of diazepam or bromazepam paralleled development of plasma levels of these drugs. ... increased EEG beta activity, the relationship between measurable bromazepam blood levels and the degree of EEG changes ...
Tópico(s): Neuroscience and Neuropharmacology Research
1976 - Wiley | Clinical Pharmacology & Therapeutics
Morton A. Schwartz, Edward Postma, Stanley J. Kolis, Arthur S. Leon,
The biotransformation of bromazepam, 7-bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one, was studied in four species. ... women given single 12-mg. oral doses of bromazepam-5-14C were the conjugated forms of 3- ... dogs and four groups of mice administered 14C-bromazepam, but its excretion by four rats was very ... mouse. Although the pyridyl N-oxide derivative of bromazepam was not detected as a metabolite in any ...
Tópico(s): Diet and metabolism studies
1973 - Elsevier BV | Journal of Pharmaceutical Sciences
... t.i.d.; Day 7: 5 mg) and bromazepam (acute: 6 mg; subchronic: 2 mg t.i. ... identification parameters after acute and subchronic administration. After bromazepam the respective parameters were significantly impaired - acutely as ... Acute and subchronic buspirone was significantly superior to bromazepam with regard to the majority of psychophysiological parameters. ... fewer acute and subchronic side effects than with bromazepam. The side effect profiles of the three preparations ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
1989 - Thieme Medical Publishers (Germany) | Pharmacopsychiatry
... a novel ion – selective membrane sensors for determining bromazepam drug are described. The sensor was based on the use of bromazepam – phosphotungestiate ion association complex as an electroactive material ... s. The selectivity coefficients indicate excellent selectivity for bromazepam over many common cations (e.g., Na+, K+, ... sensors are used successfully for the determining of bromazepam in pure form and pharmaceutical preparations with average ...
Tópico(s): Electrochemical sensors and biosensors
2009 - Elsevier BV | International Journal of Electrochemical Science
G. Podilsky, Markoulina Berger‐Gryllaki, Bernard Testa, André Pannatier,
Abstract Bromazepam and omeprazole are frequently administered to hospitalized patients to decrease anxiety and prevent stress ulcers, respectively. In ... ng/mL and 20–2000 ng/mL for bromazepam and omeprazole, respectively. The lower limit of quantification ... 5 ng/mL and 20 mg/mL for bromazepam and omeprazole, respectively. The method proved its worth in the simultaneous monitoring of bromazepam and omeprazole administered to healthy volunteers.
Tópico(s): Analytical Methods in Pharmaceuticals
2008 - Taylor & Francis | Journal of Liquid Chromatography &Related Technologies
Hervé Le Solleu, F. Demotes‐Mainard, G Vinçon, B Bannwarth,
... method has been developed for the determination of bromazepam, an anxiolytic benzodiazepine, in plasma. After a single- ... at +4 degrees C showed no degradation of bromazepam. However, bromazepam seemed to be degraded at ambient temperature, without ... This method is applied to the determination of bromazepam plasma levels in analytical toxicology.
Tópico(s): Anesthesia and Sedative Agents
1993 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis