Andres De la Rossa, Camilla Bellone, Bruno Golding, Ilaria Vitali, Jonathan Moss, Nicolas Toni, Christian Lüscher, Denis Jabaudon,
Tópico(s): RNA Interference and Gene Delivery
2013 - Nature Portfolio | Nature Neuroscience
Felice Senatore, Carmen Formisano, Aïda Raio, Gabriella Bellone, Maurizio Bruno,
The volatile constituents of the flowerheads of Centaurea nicaeensis All., C. parlatoris Helder and C. solstitialis L. ssp. schouwii (DC.) Dostál were extracted by hydrodistillation and analysed by GC and GC-MS. Altogether 113 components were identified. Fatty acids and hydrocarbons were the most abundant components in the oils. Caryophyllene and caryophyllene oxide were the main compounds of the sesquiterpene fraction. The study on the biological activity of the oils shows no significant activity.
Tópico(s): Essential Oils and Antimicrobial Activity
2008 - Taylor & Francis | Natural Product Research
Carmen Formisano, Enrico Mignola, Daniela Rigano, Felice Senatore, Gabriella Bellone, Maurizio Bruno, Sergio Rosselli,
Abstract The essential oil of aerial parts of Micromeria fruticulosa (Lamiaceae) growing wild in Southern Italy was obtained by hydrodistillation and analysed by GC and GC–MS. Sixty‐one compounds, representing 91.3% of the oil, were identified. The major components were γ ‐terpinene (14.5%), β ‐caryophyllene (12.6%), p ‐cymene (8.9%), α ‐pinene (8.2%) and β ‐bisabolene (7.2%). The essential oil showed action mainly against Gram‐positive bacteria. Copyright © 2007 John Wiley & Sons, Ltd.
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2007 - Wiley | Flavour and Fragrance Journal
C. Forimsano, F Senatore, Gabriella Bellone, Maurizio Bruno, A. Grassia, Aïda Raio, Daniela Rigano,
The volatile constituents of the flowerheads of Centaurea polymorpha Lag. were extracted by hydrodistillation and analysed by GC and GC-MS. 63 components, amounting to 91.6% of the oil, were identified. Waxes and sesquiterpenes were the most abundant components in the oil. α-Cedrene (3.9%), β-cedrene (3.6%) and β-curcumene (3.0%) were the most representative sesquiterpene hydrocarbons while caryophyllene oxide (2.6%) was the most abundant oxygen containing sesquiterpene. The study on the biological ...
Tópico(s): Phytochemistry and Biological Activities
2006 - Polish Chemical Society | Polish Journal of Chemistry
Emilio Di Maria, Rossella Gulli, Silvia Begni, Alessandro De Luca, Stefano Bignotti, Augusto Pasini, Emilia Bellone, Antonio Pizzuti, Bruno Dallapiccola, Giuseppe Novelli, Franco Ajmar, Massimo Gennarelli, Paola Mandich,
A well established model for the pathophysiology of schizophrenia postulates a role for the NMDA-mediated glutamate transmission. The human gene coding for the 2B subunit of the NMDA receptor (GRIN2B) is considered a candidate based on its selective expression in brain. To evaluate the hypothesis that GRIN2B acts as a major gene in determining susceptibility to schizophrenia, a case-control association study was performed. Five single nucleotide polymorphisms (SNPs) were genotyped in 188 Italian patients ...
Tópico(s): Receptor Mechanisms and Signaling
2004 - Wiley | American Journal of Medical Genetics Part B Neuropsychiatric Genetics
Sergio Rosselli, Antonella Maggio, Gabriella Bellone, Maurizio Bruno,
The first natural occurring cyclic carbonate terpenoid, the guaianolide hololeucin (1), was isolated from the aerial part of Centaurea hololeuca. Its structure was elucidated on the basis of extensive proton, 13C and two-dimensional NMR experiments, as well as by transformation in its diacetyl derivative.
Tópico(s): Phytochemistry and Biological Activities
2006 - Elsevier BV | Tetrahedron Letters
Felice Senatore, Carmen Formisano, A. Grassia, Daniela Rigano, Gabriella Bellone, Maurizio Bruno,
Abstract The essential oil from aerial parts of Phagnalon saxatile (L.) Cass. (Asteraceae) was obtained by hydrodistillation. The oil content was 0.15% (v/w), on a dry weight basis. The oil composition was analyzed by GC and GC/MS. Altogether 66 compounds were identified accounting for 93.2% of the oil. Sesquiterpenes represent the 23.9% of the oil. In the oil were also present fatty acids (21.8%) and waxes (19.3%). The oil shows no antibacterial activity.
Tópico(s): Natural product bioactivities and synthesis
2005 - Taylor & Francis | Journal of Essential Oil Bearing Plants
Tópico(s): Theology and Canon Law Studies
1967 - Patristic Institute Augustinianum | Augustinianum
Carmen Formisano, Felice Senatore, Maurizio Bruno, Gabriella Bellone,
Abstract The essential oil of aerial parts of Phlomis ferruginea (Lamiaceae), growing wild in Southern Italy, was obtained by hydrodistillation and analysed by GC and GC–MS. 60 compounds, representing 92.3% of the oil, were identified. The major components were β ‐caryophyllene (15.6%), hexadecanoic acid (12.8%), germacrene D (8.9%), caryophyllene oxide (6.7%) and α ‐thujone (5.5%). The evaluation of antimicrobial activity against some bacterial species has been tested. Copyright © 2006 John Wiley & Sons, Ltd.
Tópico(s): Natural product bioactivities and synthesis
2006 - Wiley | Flavour and Fragrance Journal
Produção Nacional
Revisado por pares
Patrícia Duarte Deps, Sebastian Lucas, Adriana María Porro, Solange M. Maeda, Jane Tomimori, Cássio Cesar Guidella, Tânia Reuter, Nayara Nunes de Oliveira, Brunela Pitanga Ramos Madureira, Vanda Akico Ueda Fick de Souza, Rafael Maffei Loureiro, Bruno Lima Alves, Andrea Bellone, Diana N.J. Lockwood,
Both leprosy and human immunodeficiency virus (HIV) are infectious diseases, and are an important global health problem. Patients with leprosy who are co‐infected with HIV seem to be at higher risk of developing leprosy reactions. To examine the histological features of leprosy in patients with HIV and leprosy co‐infection, particularly to determine whether the typical leprosy histopathology is present in skin biopsies, and to assess the histological features of leprosy reactions in co‐infected patients. ...
Tópico(s): Syphilis Diagnosis and Treatment
2013 - Oxford University Press | Clinical and Experimental Dermatology
J. Bellone, Gianluca Aimaretti, E Bartolotta, L Benso, Bruno P. Imbimbo, V Lenhaerts, Romano Deghenghi, F. Camanni, Ezio Ghigo,
The objective of this study was to verify the GH-releasing activity of a synthetic hexapeptide, hexarelin (HEX), before and during puberty. Ninety-six children (54 boys and 42 girls, aged 4.1-17.4 yr) were studied. Fifty-two of the children were prepubertal, and the other 44 were in pubertal stage II-IV. The GH response to 2 micrograms/kg HEX, iv (n = 56), was higher (P < 0.001) than that induced by 1 microgram/kg GHRH, iv (n = 33). The iv dose of 2.0 micrograms/kg HEX induced a greater GH increase (P < 0.02) ...
Tópico(s): Hypothalamic control of reproductive hormones
1995 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Marina Grandis, Rossella Gulli, Denise Cassandrini, Elisabetta Gazzerro, Luana Benedetti, E Narciso, Lucilla Nobbio, Claudio Bruno, Carlo Minetti, Emilia Bellone, Lizia Reni, Gianluigi Mancardi, Paola Mandich, Angelo Schenone,
Tópico(s): Celiac Disease Research and Management
2010 - Springer Science+Business Media | Neurological Sciences
Sergio Rosselli, Maurizio Bruno, Antonella Maggio, Gabriella Bellone, Tzu-Hsuan Chen, Kenneth F. Bastow, Kuo‐Hsiung Lee,
Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an α,β-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 μM, respectively. These two 1-analogues are promising lead compounds for further ...
Tópico(s): Phytochemical compounds biological activities
2007 - American Chemical Society | Journal of Natural Products
Sergio Rosselli, Maurizio Bruno, Antonella Maggio, Gabriella Bellone, Carmen Formisano, Carlo Andrea Mattia, Simone Di Micco, Giuseppe Bifulco,
Abstract Two new cyclized C ‐geranylated flavonoids, the dihydroflavonol bonanniol C ( 4a ) and the flavanone bonannione B ( 6a ), were isolated as minor compounds from the aerial parts of Bonannia graeca (Umbelliferae). Their structures were elucidated by a combined approach of extensive spectroscopic means and quantum mechanical methods. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Tópico(s): Bioactive Compounds and Antitumor Agents
2007 - Wiley | European Journal of Organic Chemistry
Antonio Pizzuti, Giuseppe Novelli, Antonia Ratti, Francesca Amati, Roberta Bordoni, Paola Mandich, Emilia Bellone, Emanuela Conti, Mario Bengala, Aldo Mari, Vincenzo Silani, Bruno Dallapiccola,
We have isolated a few cDNAs from different human tissues, transcribed from the first intron of HIRA, a gene deleted in the DiGeorge syndrome. These cDNAs are produced by an intronic gene (22k48) which is transcribed by the HIRA opposite strand and is itself arranged in exons and subjected to alternative splicing. The longest continuum cDNA sequence we obtained is 3.6 kb long and contains 3 different exons and 2 introns. 22k48 cDNA is composed of several tandemly arranged repeated elements (Alu, LINEs, ...
Tópico(s): RNA and protein synthesis mechanisms
1999 - Elsevier BV | Molecular Genetics and Metabolism
Rosa Angela Raccuglia, Gabriella Bellone, Kristina Ložienė, Franco Piozzi, Sergio Rosselli, Antonella Maggio, Maurizio Bruno, Monique S. J. Simmonds,
From the aerial parts of Scutellaria hastifolia, family Lamiaceae (Labiatae), seven neo-clerodane diterpenoids (hastifolins A–G) were isolated. The products are similar to the known scuteparvin and are characterized by being trans-cinnamoyl derivatives. Structures and stereochemistry were determined by intensive NMR investigation. Six of the products form three pairs of epimers at C-13. Hastifolins A–C showed significant antifeedant activity.
Tópico(s): Natural product bioactivities and synthesis
2010 - Elsevier BV | Phytochemistry
Bruno Dallapiccola, Paola Mandich, Emilia Bellone, Angelo Selicorni, Vahe Mokin, Franco Ajmar, Giuseppe Novelli,
We report on molecular studies in 7 patients with Wolf-Hirschhorn syndrome (WHC) not showing an obvious chromosome 4p deletion. Analysis of a set of polymorphic probes mapping in the 4p16.3 region showed the absence of paternal haplotypes in 5 cases, and maternal haplotypes in 2. These observations corroborate evidence for preferential paternal origin of the de novo 4p chromosome deletion. The overall results of molecular studies suggest that the preponderance of paternally derived WHC could be due, ...
Tópico(s): Genomics and Chromatin Dynamics
1993 - Wiley | American Journal of Medical Genetics
Bruno Golding, Gabrielle Pouchelon, Camilla Bellone, Sahana Murthy, Ariel A. Di Nardo, Subashika Govindan, Masahuro Ogawa, Tomomi Shimogori, Christian Lüscher, Alexandre Dayer, Denis Jabaudon,
Highlights•Inhibition controls levels of activity in excitatory circuits•Inhibitory neurons (INs) integrate thalamic visual circuits during development•Retinal activity directs the migration and functional circuit integration of these INs•Input-dependent mechanisms control circuit inhibition in development and evolutionSummaryInhibitory interneurons (INs) critically control the excitability and plasticity of neuronal networks, but whether activity can direct INs into specific circuits during development ...
Tópico(s): Neuroscience and Neuropharmacology Research
2014 - Cell Press | Neuron
Sergio Rosselli, Antonella Maggio, Gabriella Bellone, Carmen Formisano, Adriana Basile, Carla Cicala, Alessio Alfieri, Nicola Mascolo, Maurizio Bruno,
The phytochemical investigation of the acetone and methanol extracts of the flowers of Magydaris tomentosa (Desf.) DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product. The antibacterial activity of umbelliprenin (1), osthol (2), imperatorin (3), citropten (4) and (+)-meranzin hydrate (7) was tested against Gram-positive and Gram-negative bacteria. All coumarins (1-7) isolated in this study inhibited growth of all bacterial strains tested (MIC between ...
Tópico(s): Synthesis and Biological Activity
2007 - Thieme Medical Publishers (Germany) | Planta Medica
Nunziata Morabito, Antonino Catalano, Agostino Gaudio, E. Morini, Lucia Maria Bruno, Giorgio Basile, Eleni Tsiantouli, Federica Bellone, Rita Maria Agostino, Basilia Piraino, Maria Angela La Rosa, Carmelo Salpietro, Antonino Lasco,
Tópico(s): Hemoglobinopathies and Related Disorders
2015 - Springer Science+Business Media | Journal of Bone and Mineral Metabolism
Carmen Formisano, Felice Senatore, Maurizio Bruno, Sergio Rosselli, Gabriella Bellone, Vivienne Spadaro,
Ninety-four components of the essential oils from aerial parts and capitula of Tanacetum vulgare subsp. siculum (Guss.) Raimondo et Spadaro were detected. Alpha-Thujone, beta-thujone and 1,8-cineole were the main constituents of the oils. The analysis allows the assignment of this Tanacetum species to the thujone chemotype.
Tópico(s): Phytochemistry and Biological Activities
2009 - SAGE Publishing | Natural Product Communications
Paola Mandich, Gabriella Restagno, Giuseppe Novelli, Emilia Bellone, Lucia Potenza, O. Varetto, Bruno Dallapiccola, A. O. Carbonara, F. Ajmar,
Abstract A survey of 29 families with Adult Polycystic Kidney Disease (ADPKD) was performed to evaluate the genetic heterogeneity of the disease in Italy. The approach was through the linkage between the disease and 2 polymorphic DNA fragments as detected by the probes 3′HVR and 24.1. Linkage between the polymorphic markers and the disease was confirmed, with the following lod scores: between 3′HVR and ADPKD1 = 12.974 at θ = 0.02; between 24.1 and ADPKD = 1.716 at θ = 0.07; between 3′HVR and 24.1 = 2.738 at ...
Tópico(s): Prenatal Screening and Diagnostics
1990 - Wiley | American Journal of Medical Genetics
Bruno Golding, Gabrielle Pouchelon, Camilla Bellone, Sahana Murthy, Ariel A. Di Nardo, Subashika Govindan, Masahuro Ogawa, Tomomi Shimogori, Christian Lüscher, Alexandre Dayer, Denis Jabaudon,
(Neuron 81, 1057–1069; March 5, 2014) The original version of this article omitted two citations. These papers provide a seminal description of retinal waves (Meister et al., 1991) and their effects on retinogeniculate patterning (Penn et al., 1998). These citations have been added, and the article has now been corrected online. Retinal Input Directs the Recruitment of Inhibitory Interneurons into Thalamic Visual CircuitsGolding et al.NeuronMarch 05, 2014In BriefHow distinct neurons assemble to form ...
Tópico(s): Neural dynamics and brain function
2014 - Cell Press | Neuron
Simona Pigullo, Alessandro De Luca, Paolo Barone, Roberta Marchese, Emilia Bellone, Alessia Colosimo, Cesa Scaglione, Paolo Martinelli, Emilio Di Maria, Antonio Pizzuti, Giovanni Abbruzzese, Bruno Dallapiccola, Franco Ajmar, Paola Mandich,
Tópico(s): Cellular transport and secretion
2004 - Elsevier BV | Parkinsonism & Related Disorders
Paolo Gasparini, Paola Mandich, Giuseppe Novelli, Emilia Bellone, Federica Sangiuolo, Stefano Federici, Lucia Potenza, Elisabetta Trabetti, M. Marigo, Pier Franco Pignatti, Bruno Dallapiccola, F. Ajmar,
Several variable number of tandem repeat (VNTR) DNA polymorphisms detecting different loci (YNH24/MspI or TaqI, CMM101/MspI or MLJ14/MspI, EFD64.2/RsaI or Hinfl, YNZ22/TaqI, AW101/EcoRI, EKMDA2.1/PvuII and 3'-HVR/PvuII) were used in the analysis of 27 cases of disputed paternity in the Italian population. Fourteen exclusions and 17 attributions were performed. The results were compared with those obtained with immunohematologic analyses. Four exclusions and 2 attributions were made possible only by ...
Tópico(s): Forensic and Genetic Research
1991 - Karger Publishers | Human Heredity
Massimo Volpe, Giovanna Gallo, Maria Grazia Modena, Claudio Ferri, Giovambattista Desideri, Giuliano Tocci, Simonetta Bellone, Marco Bertolotti, Alessandro Biffi, Agostino Consoli, Alberto Corsini, Giulio Nati, Matteo Pirro, Speranza Rubattu, Bruno Trimarco, Saula Vigili de Kreutzenberg, Roberto Volpe,
This executive document reflects and updates the key points of a Consensus document on Cardiovascular (CV) Prevention realized through the contribution of a number of Italian Scientific Societies and coordinated by the Italian Society of Cardiovascular Prevention (SIPREC). The aim of this executive document is to analyze and discuss the new recommendations introduced by international guidelines for the management of major CV risk factors, such as hypertension, dyslipidemias and type 2 diabetes, consisting ...
Tópico(s): Blood Pressure and Hypertension Studies
2022 - Adis, Springer Healthcare | High Blood Pressure & Cardiovascular Prevention
Salvatore Cassese, Giuseppe De Luca, Bruno Villari, Sérgio Berti, Pietro Bellone, Alfonso Alfieri, Antonio Montinaro, Gaetano Quaranta, Paolo Marraccini, Federico Piscione,
Abstract Objectives : The Multicentre registry with Antiplatelet TReatment two–sIX months (MATRIX) evaluated safety and efficacy at 12‐month follow‐up of Janus Flex stenting with 2‐ or 6‐month dual antiplatelet therapy (DAT) period. Background : There are no data of Janus Flex stent (Carbostent and Implantable Devices—CID, Saluggia, Italy), a polymer‐free, tacrolimus‐eluting coronary stent, followed by short‐term DAT, in daily practice. Methods : Patients were prospectively enrolled at 12 high‐volume procedures ...
Tópico(s): Acute Myocardial Infarction Research
2011 - Wiley | Catheterization and Cardiovascular Interventions
Daniela Rigano, Carmen Formisano, F Senatore, Gabriella Bellone, Maurizio Bruno, Sergio Rosselli,
Micromeria is a genus of fragrant plants which comprises Mediterranean perennial sub shrubs or herbs or chamaephytes common in open habitats and in rocky coasts. Several extracts from these plants are used in folk medicine against heart disorders, headache, wound skin infections and as antispasmodic, stimulant and expectorant [1, 2]. The extracts of some Micromeria sp. exhibited significant antibacterial activity [3]. Micromeria fruticulosa (Bertol.) Grande is a suffruticous plant 8–15cm tall, endemic ...
Tópico(s): Plant chemical constituents analysis
2006 - Thieme Medical Publishers (Germany) | Planta Medica
Massimo Volpe, Allegra Battistoni, Paolo Bellotti, Simonetta Bellone, Marco Bertolotti, Alessandro Biffi, Agostino Consoli, Alberto Corsini, Giovambattista Desideri, Claudio Ferri, Maria Grazia Modena, Giulio Nati, Matteo Pirro, Speranza Rubattu, Giuliano Tocci, Bruno Trimarco, Roberto Volpe, Saula Vigili de Kreutzenberg,
In 2020, the Sars-Cov-2 pandemic is causing a huge and dramatic impact on healthcare systems worldwide. During this emergency, fragile patients suffering from other comorbidities, especially patients susceptible to or affected by cardiovascular disease, are the ones most exposed to the poorer outcomes. Therefore, it is still mandatory to continue to strictly adhere to the rules of cardiovascular prevention. This document aims to provide all doctors with simple and clear recommendations in order ...
Tópico(s): Healthcare Systems and Public Health
2020 - Adis, Springer Healthcare | High Blood Pressure & Cardiovascular Prevention
Chiara Fiorillo, Giovanna Capodivento, Alessandro Geroldi, Stefano Tozza, Isabella Moroni, Payam Mohassel, Matteo Cataldi, Chiara Campana, Simone Morando, Chiara Panicucci, Marina Pedemonte, Noemi Brolatti, Sabrina Siliquini, Monica Traverso, Serena Baratto, Doriana Debellis, Stefania Magri, Valeria Prada, Emilia Bellone, Vincenzo Salpietro, Sandra Donkervoort, Kenneth Gable, Sita D. Gupta, Teresa Dunn, Carsten G. Bönnemann, Franco Taroni, Claudio Bruno, Angelo Schenone, Paola Mandich, Lucilla Nobbio, Maria Nolano,
Abstract Aims SPTLC1 ‐related disorder is a late onset sensory‐autonomic neuropathy associated with perturbed sphingolipid homeostasis which can be improved by supplementation with the serine palmitoyl‐CoA transferase (SPT) substrate, l ‐serine. Recently, a juvenile form of motor neuron disease has been linked to SPTLC1 variants. Variants affecting the p.S331 residue of SPTLC1 cause a distinct phenotype, whose pathogenic basis has not been established. This study aims to define the neuropathological ...
Tópico(s): Genetic Neurodegenerative Diseases
2022 - Wiley | Neuropathology and Applied Neurobiology