Srikumar Sen, Boxing Correspondent, Chris Peachment, Philip Sassoon, Frances Gibb, Legal Affairs Correspondent, Michael Wines, Clifford Longley, Nick Nuttall, Andrew McEwen, Anatol Lieven, Christopher Warman, Property Correspondent, Alan King-Hamilton, Andrew Morgan, (Richard Eaton), Cliff Feltham, Michael Stevenson, Philip Howard, Hilary Finch, Roddy Macleod, Jeremy Kingston, Mark Ellis, Richard Evans, Media Editor, Colin Narbrough, Joyce Sears, Mr Menzies Campbell, R. T. Arguile, Mitchell Platts, Mitchell Platts, Golf Correspondent, Michael Ogden, Kingsley Amis, Alan Lorimer, Peter Ball, Alice Crosthwaite, Jamie Dettmer, Irish Affairs Correspondent, David Bernstein, Steve Maslin, Peter Waymark, Michael R. G. Spiller, Alan Hamilton, Rosemary Unsworth, (Michael Hornsby), Jenny MacArthur, John Young, David Hands, Stuart Jones, Football Correspondent, Woodrow Wyatt, Elizabeth Fowler, Richard Thomson, Banking Correspondent, Edward Gorman, Martin Fletcher Political Reporter, H. F., Norman de Mesquita, Jack Waterman, Leslie Tilley, Steven Downes, Javed Akhtar, David Cross, Sydney Friskin, Nicholas Harling, Fred Parker, (Dick Hinder), Mitchell Platts Golf Correspondent, (Michael Phillips), Patrick Colquhoun, Hans Binnendijk, Wolfgang Münchau, Mark Powlson, Sam Kiley and Douglas Broom, Derek Wyatt, William Holmes, David Brewerton Executive Editor, Alan Lee, Cricket Correspondent, John Russell Taylor, Raymond Keene, Chess Correspondent, Dennis Shaw, Ken Gosling, Yuri Matischen, Gilbert Longden, David Lowry, Andrew McEwen, Diplomatic Correspondent, Peter Bryan, Steve Acteson, Beryl Dixon, C. J. Cornwall, Phil McLennan, Alun Anderson, Robert Rodwell, Tim Ewbank, Robert Matthews, Crawford Knox, Jill Sherman, Craig Seton, Stewart Tendler, Crime Reporter, David Young, Energy Correspondent, Barry Pickthall, Irving Wardle, Ian Ross, Nicholas Wood and Philip Webster, J. P. S. Allison, Sheila Gunn Political Staff, Geof Wheelwright, John Goodbody, Christopher Walker, Carol Ferguson, George Hill, Sam Kiley, Higher Education Reporter, Matthew Parris, Paul Newman, Liz Smith, Sarah Jane Checkland Art Market Correspondent, Keith Blackmore, Owen Jenkins, A. S. Graham, Michael Clark and Geoffrey Foster, Louis F. Brody, Bill Cash, David Walker, Marshalls Halifax, Stephen Pettitt, Peter Dear and Greta Carslaw, Pat Sweet, Martin Waller, Roddy Mackenzie, Michael Horsnell, (Christopher Goulding), Bailey Morris, Tom Pike, Thelma Beale, Martin Fletcher and Robin Oakley, Rodney Lord, Economics Editor, Michael Evans Defence Correspondent, Keith Macklin, Derek Pearson, Maria Scott, Andrew McEwen Diplomatic Correspondent, Harvey Elliott Air Correspondent, Philip Jacobson, David Hands, Rugby Correspondent, J. M. Pick, Mary Dejevsky, (John Best), Geoffrey Lee Williams, Jill Sherman and Ian Smith,
... up Japanese politics Meeting Gray's Inn Primo Conti Florentine Futurist painter Latest wills Festival of St ... who turned self-made manager Court battle for Bruno cash Boxing South African offer for McKenzie ILEA ...
1988 - Gale Group | TDA
Edith Lahner, Laura Conti, Bruno Annibale, Vito D. Corleto,
Tópico(s): Gastrointestinal disorders and treatments
2020 - Springer Science+Business Media | Current Gastroenterology Reports
Joe Montana, Jonathan Northcroft, Waldemar Januszczak, John Dugdale, Hala Jaber, William Kay, Barbara Hall, Trevor Beattie, N J, Fred Redwood, Sally Brock, Helen Davies, Dana Facaros, Mike Quelch, Robert Wilson, Neil Meadows, John Peter, Mohsen Miraftab, Dan Calrns, Clare Smales, Professor Gideon Garter, Amanda Ursell, Bruce Millar, Susan Cullen, Andrew Longmore, Sean O'Connor, Adam Hathaway, Nicky Perry, Susan d'Arcy, Christian Purefoy, Sally Emerson, Edna Weiss, Frank Whitford, Ivo Tennant, Terence Blacker, David Gower, Dennis Pallis, Kathryn Cooper, Mia Ogden, William Lewis, David Smith, Steven Mithen, Tim Richards, Owen Lindsell, David Cracknell Political Editor, Nick Pitt, V Green, Neil Wormald, G H D, Andrew Sullivan, Clive Davis, Stephen Grey, Malcolm Bodfish, F Gadd, Andrew Porter, Glyn Hughes, Tony Allen-Mills, Simon Wilde, David Cairms, Jonathan Ungoed-Thomas, Alexander Campbell, Anthony Sattin, Martin James, Robert Winnett, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Adrian Furnham, Matt Rudd, Mark Dallan, Peter Wilson, Rosie Millard, Roisin Nield, David Dougill, Frank Graham, Stuart Barnes, Sarah Webb, Geraldine Hackett, Angela Rippon, David Hewson, Cally Law, Hugh Canning, L el Jassar, Graham Duffill, Jeremy Clarkson, Sir Ian Blair, Philip Smith, Edward Porter, Nicola Smith, Clare Gascoigne, Michael Portillo, David Cairns, Stewart Lee, Patricia Nicol, Anthony Peregrine, Sarah Dempster, Andrew Holgate, Dave Pollard, Lorry Brakes, Richard Fletcher, John Hart, Geoff Bradford, Greg Struthers, Peter Kellner, David Eimer, James Delingpole, Jeff Potter, Jeremy Guscott, Anthony Whitehouse, Pat Malone, David Walsh Chief Sports Writer, Freddie Mitchell, Ray Mitchell, Mike Laws, Paul Ham, Nick Fieiding, Sarah-Kate Templeton, Stuart Wavell, James Finnegan, Alastair Harrison, Paul Donovan, Christopher Silvester, Sheikh Maktoum, Edward Gorman, Vincent Crump, Paul Kimmage, Julia Hausermann, Hugh McIlvanney, Chris Woodhead, A Aherne, Steve Boyd, Jasper Gerard, Fiona Wilson, Michael Woodhead, Paul Driver, Harriet Griffey, Nicholas Hellen, Richard Brooks, Reg Bamford, John Follain, Ian Hawkey, Julie Earle-Levine, Robert Swindells, Christopher Morgan, David Leppard, Stuart Andrews, Paul Durman, Martin Johnson, Stuart Anderws, Shelley Von Strunckel, Dave Hannigan, Mark Edwards, Joanna Briscoe, Sarah Gracie, Keith Watson, Paul Martin, Susan Clark, Dermot McManus, Dr Linda Hadfield, Kira Cochrane, Michael Wadge, Ben Farmer, Alan Combes, Sean Newsom, Raymond Keene, Gareth Huw Davies, Rod Liddle, David Cracknell, Bob Low, Tim Wynne-Jones, Zoe Brennan, Cosmo Landesman, Robbie Hudson, Colin Smith, Emma Smith, Stephen Jones, Eddie Jordan, Dominic O'Connell, Barry Flatman, Uzi Mahnaimi, Nick Cain, Louise Armitstead, Peter Koenig, Blower Spindle, Graham Richards, Natalie Graham, Roger Jackson, Adrienne Connors, Lucy Atkins, Sue Fox, Caroline Donald, Nick Rennison, Jessica Brinton, S A, Stanley Parr, David Walsh, Miranda Seymour, Liat Joshi, Trevor Lewis, Tim Bradshaw, Bryan Appleyard, Caroline Scott, Jan Ravens, Stephen Armstrong, John Elliott, Peter Leslie, Ron Clarke, Bethan Cole, Roger Panting, Victoria O'brien, George Donson, Roland White, G J, Helen Statham, Helen Jones, Shane Watson, Abul Taher, Jonathan Heaf, Amrit Dhillon, Maurice Chittenden, Richard Brooks Arts Editor, Virginia Rounding, Victoria Segal, Richard Rae, Mark Franchetti, Ray Hutton, Jon Ungoed-Thomas, Jackson Way, Brendan Simms, James Wyatt, Dan Box, Amanda Craig, John Harlow, Dipesh Gadher, John Waples, Hunter Davies, A A Gill, David Parsons, Alex Pell, Ros Dodd, Matthew Campbell, Brian Glanville, J M, John Carey, Robert MacFarlane, Tom Hagler, David Rewan, Mary Braid, Sarah Curtis, Stephen Pettitt, Steve Cole, Chrissy Iley, Will Iredale, Jessica Bown, Jeremy Langmead, Justin Sparks, Sally Kinnes, Naomi Caine, Liam Clarke, Matthew Shave, Roger Dobson, Peter Schmeichel, Minette Marrin, John Aizlewood, Ben Dowell, Clifford Bishop, Graham Norwood, Joe Lovejoy, Jonathan Futrell, David Budworth, William Lewis Business editor, Hugh Pearman, Dan Cairns, Clive Hetherington, Pete Oliver, Amir Taheri, Frank Field, Stewart Mitchell, Manish Agarwal, David Smith Economics Editor, Mariane Pearl, Rachel De Thame, Tom Deveson, Sarah Baxter, Brian Schofield, Kate Spicer, Matthew Goodman, India Knight, I S, Tony Grayson, Fiona Henderson, Simon Howard, Ed Hughes, Dominic Rushe, Sian Griffiths, Karen Robinson, Helen Stewart,
... by the Unyielding Rules My name's Tom Conti I'm here to see Mayor ken and ... Fiegende Hollander WDR Radio Choir, Cappella Colonlendsis, cond Bruno Well Deutsche Harmonia Mundi 82876 64071 2 (2 ...
2005 - Gale Group | Sunday Times HA GDA
Eyüp S. Canlar, Mauro Conti, Bruno Crispo, Roberto Di Pietro,
More and more often, smartphones are relevant targets of civil and criminal investigations. Currently, there are several tools available to acquire forensic evidence from smartphones. Unfortunately, most of these tools require to connect the smartphone under investigation through a cable to an external device, like a computer or a multimeter. Some tools even require to disassemble the chips from the smartphone board. In this paper, we propose LiveSD Forensics, an on-device live data acquisition ...
Tópico(s): User Authentication and Security Systems
2013 - Elsevier BV | Journal of Network and Computer Applications
By Peter Hill, Industrial Editor, By Hugh Noyes, Parliamentary Correspondent., By Jonathan Davis, Energy Correspondent, By Philip Webster Political Correspondent, By Our Labour Editor, By Our Foreign Staff, By David Nicholson-Lord, From Roger Boyes, From Peter Watson, From Richard Ford, From Arthur Osman, By Paul Routledge, Labour Editor, By David Felton Labour Correspondent, By Frances Gibb, By Annabel Ferriman, Health Services Correspondent, By Diana Geddes Education Correspondent, By Our Political Staff, By Stewart Tendler, Crime Reporter, By Tony Samstag, By John Chartres, By Philip Webster, Political reporter, From Jonathan Wills, By Richard Evans, From Our Correspondent, By Anthony Bevins, Political Correspondent, By Ronald Faux, By Kenneth Gosling, By Lucy Hodges, By John Young, Agricultural Correspondent, From James Hutchinson, From Michael Hornsby, From Rasit Gurdilek, From Christopher Walker, From Robert Fisk, From Charles Hargrove, From Michael Binyon, From Richard Wigg, From Mario Modiano, From Peter Nichols, From an Murray, From Nicholas Ashford, From Christopher Thomas, By Edward Mortimer, By Caroline Moorehead, Philippa Toomey, Brian Alderson, Vivien Morgan, by Nicholas Wapshott, PHS, Alan Hamilton, CORRELLI BARNETT, A. F. KREIDER, DAVID PIACHAUD, PATRICK CARROLL, CAROLINE HOLBROOK, HENRY DURANT, ALASTAIR BLACK, KEN GILL, MALCOLM SAMUEL, H. M. DANCE, JIMSON PARSONS, HAMILTON OF DALZELL, By Geraldine Norman, Sale Room Correspondent, By Harry Golombek Chess Correspondent, By a Bridge Correspondent, A friend, Michael Ratcliffe, John Russell Taylor, Irving Wardle, Noel Goodwin, John Percival, Christopher Warman, MICHAEL CLARK, By Our Commercial Editor, By Frances Williams, By Philip Robinson, By Edward Townsend, Industrial Correspondent, By Derek Harris Commercial Editor, By Michael Prest, From Peter Norman, By Arthur Reed, By Jonathan Davis, Clive Cookson, By Torin Douglas, By Stuart Jones, Football Correspondent, By Rex Bellamy, From John Wilcockson, By Paul Harrison, From John Woodcock, Cricket Correspondent, From Peter McFarline, By Jim Railton, By Srikumar Sen, Boxing Correspondent, From John Ballantine, By John Hennessy, Golf Correspondent, By Keith Macklin, By Peter West, Rugby Correspondent, By Paul MacWeeney, By Michael Phillips, Racing Correspondent, By Our Racing Correspondent, From Richard Eaton, By Robert Pryce, Edited by Peter Dear, By David Felton, Labour Correspondent,
... Multiple Display Advertisements, Silk Cut, Hon. Treasurer, Tom Conti, South Africa, Taylor Woodrow, Campaign, Midland, Lucie Rie, ... doubt on Cheltenham, Cycling Riding against the wind, Bruno gets go-ahead to fight, Champion Hurdle day ...
1982 - Gale Group | TDA
Lucia Berti, Gerhard Mittler, Gerhard K. H. Przemeck, Gertraud Stelzer, Barbara Günzler, Francesca Amati, Emanuela Conti, Bruno Dallapiccola, Martin Hrabé de Angelis, Giuseppe Novelli, Michael Meisterernst,
Hemizygous deletions on chromosome 22q11.2 result in developmental disorders referred to as DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS). We report the isolation of a novel gene, PCQAP (PC2 glutamine/Q-rich-associated protein), that maps to the DiGeorge typically deleted region and encodes a protein identified as a subunit of the large multiprotein complex PC2. PC2 belongs to the family of the human Mediator complexes, which exhibit coactivator function in RNA polymerase II transcription. ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2001 - Elsevier BV | Genomics
This study aimed to evaluate audiological and vestibular involvement in Fabry disease and the early effects of enzyme replacement therapy with human alpha-galactosidase A.Fourteen patients (10 males, 4 females) aged 14-57 years were studied. Each patient underwent a clinical (history of otological and vestibular aspects, otoscopy) and instrumental (pure tone and speech audiometry, impedance, auditory brainstem response and oto-acoustic emission recordings, vestibular caloric tests, electronystagmography ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2003 - Wiley | Acta Paediatrica
Mauro Conti, Bruno Crispo, Earlence Fernandes, Yury Zhauniarovich,
Current smartphone systems allow the user to use only marginally contextual information to specify the behavior of the applications: this hinders the wide adoption of this technology to its full potential. In this paper, we fill this gap by proposing CRêPE, a fine-grained Context-Related Policy Enforcement System for Android. While the concept of context-related access control is not new, this is the first work that brings this concept into the smartphone environment. In particular, in our work, ...
Tópico(s): Access Control and Trust
2012 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Information Forensics and Security
Frédéric Nicodème, Sandrine Geffroy, Massimo Conti, Bruno Delobel, Valérie Soenen, Nathalie Grardel, Henri Porte, Marie‐Christine Copin, Jean‐Luc Laï, Joris Andrieux,
Abstract Thymomas are low‐grade epithelial cancers of the thymus whose prevalence varies between 0.1/100,000 and 0.4/100,000. Familial occurrence of thymoma is very rare. We studied a family bearing the constitutional chromosome translocation t(14;20)(q24;p12), 3 of whose members had a thymoma. In this family, among 27 patients, 11 had the translocation: 3 had thymoma and 4 others had 5 different autoimmune diseases: type 1 diabetes mellitus, Graves' disease, pernicious anemia, primitive Sjögren ...
Tópico(s): Vascular Tumors and Angiosarcomas
2005 - Wiley | Genes Chromosomes and Cancer
Jaromir Vlach, Silke Hennecke, Konstantinos Alevizopoulos, Daniele Conti, Bruno Amati,
Research Article2 December 1996free access Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. J. Vlach J. Vlach Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland. Search for more papers by this author S. Hennecke S. Hennecke Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland. Search for more papers by this author K. Alevizopoulos K. Alevizopoulos Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland. ...
Tópico(s): Ubiquitin and proteasome pathways
1996 - Springer Nature | The EMBO Journal
Yury Zhauniarovich, Giovanni Russello, Mauro Conti, Bruno Crispo, Earlence Fernandes,
Smartphones are very effective tools for increasing the productivity of business users. With their increasing computational power and storage capacity, smartphones allow end users to perform several tasks and be always updated while on the move. Companies are willing to support employee-owned smartphones because of the increase in productivity of their employees. However, security concerns about data sharing, leakage and loss have hindered the adoption of smartphones for corporate use. In this paper ...
Tópico(s): Network Security and Intrusion Detection
2014 - IEEE Computer Society | IEEE Transactions on Dependable and Secure Computing
Manuela Di Franco, Maria Chiara Gerardi, Fabrizio Conti, Bruno Lucchino,
Abstract: Rheumatoid arthritis (RA) management has greatly improved with the development of biologic disease modifying antirheumatic drugs, but a proportion of patients do not improve despite the biologic drugs currently available. We need new biologic agents with novel mechanisms of action for the treatment of refractory patients. Recent evidence has shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) is involved in the pathogenesis of RA. GM-CSF can exacerbate RA and elevated levels ...
Tópico(s): Peripheral Neuropathies and Disorders
2014 - Dove Medical Press | Core evidence
Laura Conti, Bruno Annibale, Edith Lahner,
Autoimmune atrophic gastritis is an organ-specific immune-mediated condition characterized by atrophy of the oxyntic mucosa. Autoimmune atrophic gastritis (AIG) is characterized by a progressive loss of acid-secreting parietal cells leading to hypo-achlorhydria. Due to this peculiar intra-gastric environment, gastric microbiota composition in individuals with autoimmune atrophic gastritis was first supposed and then recently reported to be different from subjects with a normal acidic healthy stomach. ...
Tópico(s): Microscopic Colitis
2020 - Multidisciplinary Digital Publishing Institute | Microorganisms
Andrea Picchianti Diamanti, Francesca Romana Spinelli, Maria Manuela Rosado, Fabrizio Conti, Bruno Laganà,
Phosphodiesterases (PDEs) are a heterogeneous superfamily of enzymes which catalyze the degradation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Among PDEs, PDE4 is the most widely studied and characterized isoenzyme. PDE4 blocking can lead to increased levels of intracellular cAMP, which results in down-regulation of inflammatory responses by reducing the expression of tumor necrosis factor (TNF), interleukin (IL)-23, IL-17, ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Shuei Sugama, Takato Takenouchi, Masayo Fujita, Bruno Conti, Makoto Hashimoto,
Acute stress was demonstrated to induce morphological microglial activation in several brain regions including the midbrain periaqueductal gray (PAG), an area that plays important roles in behavioral responses to uncontrollable stress, threat, anxiety, and pain. To determine whether neuronal activation may be involved in the stress-induced microglial activation, the present study investigated the correlation between neuronal activity measured as c-Fos expression and morphological microglial activation ...
Tópico(s): Stress Responses and Cortisol
2008 - Elsevier BV | Journal of Neuroimmunology
A modest reduction in body temperature prolongs longevity and may retard aging in both poikilotherm and homeotherm animals. Some of the possible mechanisms mediating these effects are considered here with respect to major aging models and theories.
Tópico(s): Circadian rhythm and melatonin
2008 - Springer Nature | Cellular and Molecular Life Sciences
Olivia Osborn, Hermann Gram, EP Zorrilla, Bruno Conti, Tamás Bartfai,
Body weight homeostasis is regulated by central and peripheral mechanisms, in which cytokines appear to have an important role.The circulating levels of the cytokines interleukin 1 (IL-1) and interleukin 18 (IL-18), and of inflammatory mediators such as prostaglandin E2 (PGE2), amongst others, are elevated in obese individuals. The low-grade inflammation associated with obesity may contribute to the development of insulin resistance, impaired glucose tolerance and type 2 diabetes. This review highlights ...
Tópico(s): Diabetes and associated disorders
2008 - EMH Swiss Medical Publishers Ltd. | Schweizerische medizinische Wochenschrift
Sameh S. Ali, Maria-Cecilia Garibaldi Marcondes, Hilda Bajova, Laura L. Dugan, Bruno Conti,
Temperature (T) reduction increases lifespan, but the mechanisms are not understood. Because reactive oxygen species (ROS) contribute to aging, we hypothesized that lowering T might decrease mitochondrial ROS production. We measured respiratory response and ROS production in isolated mitochondria at 32, 35, and 37 °C. Lowering T decreased the rates of resting (state 4) and phosphorylating (state 3) respiration phases. Surprisingly, this respiratory slowdown was associated with an increase of ROS production ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2010 - Elsevier BV | Journal of Biological Chemistry
Silvia Alboni, Claudia Montanari, Cristina Benatti, Johanna M. C. Blom, Maria Luisa Simone, N. Brunello, Federica Caggia, Gianluigi Guidotti, Maria Cecilia Garibaldi Marcondes, Manuel Sánchez-Alavez, Bruno Conti, Fabio Tascedda,
Interleukin (IL)-18 is a pro-inflammatory cytokine that is proposed to be involved in physiological as well as pathological conditions in the adult brain.IL-18 acts through a heterodimer receptor comprised of a subunit alpha (IL-18Rα) required for binding, and a subunit beta (IL-18Rβ) necessary for activation of signal transduction.We recently demonstrated that the canonical alpha binding chain, and its putative decoy isoform, are expressed in the mouse central nervous system (CNS) suggesting that IL- ...
Tópico(s): Immune Cell Function and Interaction
2010 - Elsevier BV | Brain Behavior and Immunity
Silvia Alboni, Davide Cervia, Shuei Sugama, Bruno Conti,
Abstract Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to ...
Tópico(s): Dermatology and Skin Diseases
2010 - BioMed Central | Journal of Neuroinflammation
Charles A. Dinarello, William P. Arend, John E. Sims, Dirk E. Smith, Hal Blumberg, Luke O'neill, Raphaela Goldbach‐Mansky, Theresa T. Pizarro, Hal M. Hoffman, Philip Bufler, Marcel F. Nold, Pietro Ghezzi, Alberto Mantovani, Cecília Garlanda, Diana Boraschi, Anna Rubartelli, Mihai G. Netea, Jos van der Meer, Leo A. B. Joosten, Thomas Mandrup‐Poulsen, Marc Y. Donath, Eli Lewis, Josef Pfeilschifter, Michael U. Martin, Michael Kracht, H Muehl, Daniela Novick, Miodrag L. Lukić, Bruno Conti, Alan M. Solinger, Peyman Kelk, Frank L. van de Veerdonk, Chiristopher Gabel,
IL-1 family nomenclatureTo the Editor: Newly cloned interleukin 1 (IL-1) family members [1][2][3] were originally given an IL-1 family (IL-1F) designation 4 , but as functions have now been elucidated for several of these 5,6 , we propose that each now be assigned an individual interleukin designation.IL-1F6, IL-1F8 and IL-1F9 are encoded by distinct genes but use the same receptor complex (IL-1Rrp2 and AcP), are proinflammatory and deliver nearly identical signals [7][8][9][10][11][12] .We propose these ...
Tópico(s): Whipple's Disease and Interleukins
2010 - Nature Portfolio | Nature Immunology
Manuel Sánchez-Alavez, Silvia Alboni, Bruno Conti,
Gender-specific differences in longevity are reported across species and are mediated by mechanisms not entirely understood. In C57Bl/6 mice, commonly used in aging research, males typically outlive females. Since in these animals modest but prolonged reduction of core body (Tc) increased life span, we hypothesized that differential Tc may contribute to sex-specific longevity. Here, we compared the circadian profiles of Tc and locomotor activity (LMA) of male and female C57Bl/6 mice. Since Tc and ...
Tópico(s): Stress Responses and Cortisol
2010 - Springer Science+Business Media | AGE
Sara E. Brownell, Bruno Conti,
Loss of neurons or neuronal functions over time has been hypothesized to contribute to the dysregulation of autonomic functions observed in aging. In this study, we evaluated the total number of the hypothalamic hypocretin (orexin) immunopositive neurons in 100, 400, 800 and 1000-day-old male and female C57Bl/6 mice that are commonly used in aging studies in vertebrates. Males had 15–20% more hypocretin immunopositive neurons (HIN) than females at all ages examined. Neuronal number for both sexes ...
Tópico(s): Sleep and related disorders
2010 - Elsevier BV | Neuroscience Letters
Measurement of body temperature remains one of the most common ways to assess health. An increase in temperature above what is considered to be a normal value is inevitably regarded as a sure sign of disease and referred to with one simple word: fever. In this review, we summarize how research on fever allowed the identification of the exogenous and endogenous molecules and pathways mediating the fever response. We also show how temperature elevation is common to different pathologies and how the ...
Tópico(s): Respiratory Support and Mechanisms
2010 - Hindawi Publishing Corporation | The Scientific World JOURNAL
Manuel Sánchez-Alavez, Bruno Conti, Gianluca Moroncini, José R. Criado,
In order to gain insights on the function of the cellular prion protein (PrP(C)) sleep and the levels of the stress hormones corticosterone (CORT) and the adrenocorticotropic hormone (ACTH) before and after sleep deprivation (SD) were compared in two wild type (WT) mice strains and the following three PrP(C) transgenic lines: mice null for PrP(C) (mPrP(0/0)) and mice with specific and central expression of PrP in neurons (NSE-HPrP/mPrP(0/0)) or in glia cells (GFAP-HPrP/mPrP(0/0)). After SD mPrP(0/0) mice ...
Tópico(s): Food Allergy and Anaphylaxis Research
2007 - Elsevier BV | Brain Research
Stefano Sotgiu, Anna Rosa Sannella, Bruno Conti, Giannina Arru, Ml Fois, A SANNA, Carlo Severini, Maria C. Morale, Bianca Marchetti, Giulio Rosati,
Several epidemiological investigations conducted in Sardinia, insular Italy, indicate that the strong selective pressure of malaria along the centuries may have concurred to the elevated genetic MS-risk in this region. To test such hypothesis in an experimental setting, we have compared the immune response to P. falciparum (the causative agent of malaria) in Sardinian MS patients relative to their ethnic healthy controls and control MS patients of different ethnicity. To this purpose, the P. falciparum- ...
Tópico(s): T-cell and B-cell Immunology
2007 - Elsevier BV | Journal of Neuroimmunology
Eric P. Zorrilla, Manuel Sánchez-Alavez, Shuei Sugama, Molly Brennan, Rosette E. Fernandez, Tamás Bartfai, Bruno Conti,
Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in obesity. Here, we show that administration of IL-18 suppresses appetite, feed efficiency, and weight regain in food-deprived male and female C57BL/6J mice. Intraperitoneal vs. intracerebroventricular routes of IL-18 administration had similar potency and did not promote formation of a conditioned taste aversion (malaise-like behavior). Mice partially (Il18(+/-)) or totally (Il18(-/-)) deficient in IL-18 were hyperphagic by young ...
Tópico(s): Adipose Tissue and Metabolism
2007 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Interleukin-18 (IL-18) is a pro-inflammatory cytokine believed to play a role in a variety of conditions and diseases including infections, autoimmunity, cancer, diabetes and atherosclerosis. IL-18 is also a possible contributor to the sickness syndrome by inducing anorexia and sleep. Originally recognized to be produced by cells of the immune system, IL-18 is also found in endocrine tissues, including the adrenal and the pituitary glands, and in the central nervous system where it is produced by ...
Tópico(s): Tryptophan and brain disorders
2007 - Elsevier BV | Brain Research Reviews
Tamás Bartfai, Manuel Sánchez-Alavez, Siv Andell-Jonsson, Marianne Schultzberg, Annamaria Vezzani, Erik Danielsson, Bruno Conti,
Proteins of the interleukin-1 (IL-1) system include the secreted agonist IL-1beta, and the receptor antagonist IL-1ra, both competing for binding to the IL-1 receptor (IL-1R). IL-1beta and IL-1ra are highly inducible under different forms of stress, such as excitatory neurotransmitter excess occurring during seizures, in infection and inflammation, and during neurotrauma. In each of these conditions induction of IL-1beta precedes that of IL-1ra, resulting in up to 10-20-fold elevation of IL-1beta ...
Tópico(s): Inflammasome and immune disorders
2007 - Wiley | Annals of the New York Academy of Sciences
Manuel Sánchez-Alavez, Izabella Klein, Sara E. Brownell, Iustin V. Tabarean, Christopher N. Davis, Bruno Conti, Tamás Bartfai,
Adult mice carrying a null mutation of the prostanoid receptor EP3R (EP3R(-/-) mice) exhibit increased frequency of feeding during the light cycle of the day and develop an obese phenotype under a normal fat diet fed ad libitum. EP3R(-/-) mice show increased motor activity, which is not sufficient to offset the increased feeding leading to increased body weight. Altered "nocturnal" activity and feeding behavior is present from a very early age and does not seem to require age-dependent factors for ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2007 - National Academy of Sciences | Proceedings of the National Academy of Sciences