Michel Benoît, Sandrine Andrieu, L. Lechowski, S. Gillette‐Guyonnet, Philippe Robert, Bruno Vellas,
Abstract Background Apathy and depression are the most common neuropsychiatric features in Alzheimer's disease (AD). The clinical and functional specific correlates of these syndromes are not well known independently from cognitive deficits and other behavioral disturbances. Material and methods Six hundred and eighty‐six patients diagnosed with possible or probable AD were included in a prospective multicenter study (REAL‐FR). They had an assessment of their cognitive and functional status. Neuropsychiatric ...
Tópico(s): Schizophrenia research and treatment
2007 - Wiley | International Journal of Geriatric Psychiatry
Bethsabée Partouche, Marion Pépin, Pauline Mary de Farcy, Jean‐Emmanuel Kahn, Bruno Sawczynski, L. Lechowski, Laurent Teillet, Frédéric Barbot, Marie Herr, Benjamin Davido,
Abstract Introduction Infection is one of the major causes of mortality and morbidity in older adults. Available biomarkers are not associated with prognosis in older patients. This study aimed to analyze the value of eosinopenia (eosinophil count< 100/mm 3 ) as a prognosis marker among older patients with suspected or confirmed bacterial infection. Methods A retrospective study was performed from 1 January to 31 December 2018 among patients in a geriatrics ward suffering from a bacterial infection ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2021 - BioMed Central | BMC Geriatrics
L. Lechowski, Michel Benoît, Philippe Chassagne, Isabelle Vedel, D. Tortrat, L. Teillet, Bruno Vellas,
To determine the role of persistent apathy in rapid loss of autonomy in Instrumental Activities of Daily Living (IADL) in women with Alzheimer s disease (AD), taking into account the grade of cognitive decline.The study was conducted on 272 women from the French REAL cohort. At inclusion patients had a Mini-Mental State Examination (MMSE) score between 10-26. A rapid functional decline was defined as a yearly drop of 4 points or more on the 14-point IADL Lawton scale. Persistent apathy was defined ...
Tópico(s): Functional Brain Connectivity Studies
2008 - Wiley | International Journal of Geriatric Psychiatry
L. Lechowski, Bénédicte Dieudonné, D. Tortrat, L. Teillet, Philippe Robert, Michel Benoît, B Forette, Bruno Vellas,
Abstract Background Cognitive impairment is associated with functional impairment in patients with Alzheimer's disease (AD). Behavioural disturbance is very common in these patients. Nevertheless, there has been very little research into the relations between behavioural disturbance and functional status in AD. The purpose of this study is to investigate the relationship between behavioural disturbance and functional status after taking account of cognitive impairment. Material and methods 579 patients ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2003 - Wiley | International Journal of Geriatric Psychiatry
L. Lechowski, S. Van Pradelles, Marine Le Crane, Lydie d’Arailh, D. Tortrat, Laurent Teillet, Bruno Vellas,
<i>Background/Aims:</i> To characterize loss of basic activities of daily living (BADL) in 687 Alzheimer’s disease (AD) community-dwelling patients included in the French REAL cohort. <i>Methods:</i> Patients had mild to moderately severe AD, and the mean age was 77.8 years. Patterns of loss of the 6 BADL were described at inclusion using the Lawton scale. <i>Results:</i> With 6 binary BADL scores, each patient presented at inclusion a set of losses. For 53% of women, the ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2010 - Karger Publishers | Dementia and Geriatric Cognitive Disorders
L. Lechowski, Matthieu de Stampa, Bertrand Denis, D. Tortrat, Philippe Chassagne, Philippe Robert, Laurent Teillet, Bruno Vellas,
<i>Background/Aims:</i> To determine patterns of loss of abilities in instrumental activities of daily living (IADL) in community-dwelling women with Alzheimer’s disease (AD). <i>Methods:</i> Sixteen French university hospitals included 471 consecutive women with mild to moderately severe AD (Mini-Mental State Examination scores between 10 and 26) from April 2000 to June 2002 in the noninterventional REAL cohort. At inclusion, 6 and 12 months, IADL were assessed with the Lawton ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2007 - Karger Publishers | Dementia and Geriatric Cognitive Disorders
L. Lechowski, M. Harboun, Bénédicte Dieudonné, K Hernandez, D. Tortrat, B Forette, L. Teillet, Bruno Vellas,
Tópico(s): Health, Medicine and Society
2003 - Elsevier BV | La Revue de Médecine Interne
L. Lechowski, M. Harboun, Bénédicte Dieudonné, K. Hernandez, D. Tortrat, B Forette, L. Teillet, Bruno Vellas,
La maladie d' Alzheimer (MA) atteint 2 fois sur 3 des malades âgés de plus de 80 ans, caractérisés par une plus grande fragilité, par un risque de précarité sociale et par une fréquente polypathologie. Peu de données sont disponibles concernant ces patients âgés. Le but de notre travail était d'étudier les caractéristiques des patients MA âgés de plus de 80 ans. Il s'agit d'une étude prospective multicentrique française (REAL.FR) d'une cohorte de patients vivant àdomicile, atteints d'une MA avec un ...
Tópico(s): Health, Medicine and Society
2003 - Elsevier BV | La Revue de Médecine Interne
L. Lechowski, Blandine Denis, Matthieu de Stampa, D. Tortrat, L. Teillet, Philippe Robert, Bruno Vellas,
Apathy is both a symptom and syndrome prevalent in neurodegenerative disease, including motor system disorders, that affects motivation to display goal directed functions. Levy and Dubois (2006) suggested three apathetic subtypes, Cognitive, Emotional-affective and Auto-activation, all with discrete neural correlates and functional impairments. The aim of this study was to create a new apathy measure; the Dimensional Apathy Scale (DAS), which assesses apathetic subtypes and is suitable for use in ...
Tópico(s): Healthcare Systems and Practices
2006 - Elsevier BV | La Revue de Médecine Interne
L. Lechowski, Mark Crane, Blandine Denis, F. Müller, L. Teillet, Bruno Vellas,
Tópico(s): Aging, Elder Care, and Social Issues
2008 - Elsevier BV | La Revue de Médecine Interne
L. Lechowski, L. Teillet, D. Tortrat, Bénédicte Dieudonné, B Forette, Marc Benoît, P. Brocker, Bruno Vellas,
To evaluate the optimal zinc supplementation strategy for improving growth and hematologic and micronutrient status in young Laotian children.In total, 3407 children aged 6-23 months were randomized to receive either daily preventive zinc tablets (7 mg/d), high-zinc, low-iron micronutrient powder (10 mg/d zinc, 6 mg/d iron, and 13 other micronutrients), therapeutic zinc supplementation for diarrhea (20 mg/d for 10 days per episode), or daily placebo powder; all were followed for ~9 months. Anthropometry, ...
Tópico(s): Trace Elements in Health
2003 - Elsevier BV | La Revue de Médecine Interne
Pierre Tarrade, L. Lechowski, Bernard Denis, I. Perrine, Matthieu de Stampa, F. Müller, Christian Valentin, D. Tortrat, S. Piol, Bénédicte Dieudonné, Philippe Robert, R. Boulhassas, L. Teillet, Bruno Vellas, Bruno Vellas,
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2005 - Elsevier BV | Revue Neurologique
Pierre Tarrade, L. Lechowski, Blandine Denis, I. Perrine, Matthieu de Stampa, F. Müller, Christian Valentin, D. Tortrat, S. Piol, Bénédicte Dieudonné, Philippe Robert, R. Boulhassas, L. Teillet, Bruno Vellas,
Le niveau d’études est considéré comme un facteur de réserve. Ainsi, les adultes âgés de haut niveau d’études ont de meilleures performances mnésiques que ceux ayant un niveau d’études plus bas. L’objectif de cette étude était d’examiner le rôle de la métamémoire comme un médiateur potentiel des effets du niveau d’études sur la performance mnésique. Quatre-vingt-trois adultes âgés (60–80 ans) ont été divisés en deux sous-groupes selon leur niveau d’études (haut et bas niveau). La mémoire épisodique ...
Tópico(s): Neurobiology of Language and Bilingualism
2005 - Elsevier BV | Revue Neurologique