Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice André, Attila Tordai, Jaime Mejia, W. Fraser Symmans, Ana M. González-Angulo, Bryan T. Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobágyi, Lajos Pusztai,
Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression. In this study, we compared response to neoadjuvant chemotherapy and survival between patients with TNBC and non-TNBC.
Tópico(s): HER2/EGFR in Cancer Research
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Ana M. González-Angulo, Bryan T. Hennessy, Funda Meric‐Bernstam, Ayşegül A. Şahin, Wenbin Liu, Zhenlin Ju, Mark Carey, Simen Myhre, Corey Speers, Lei Deng, Russell R. Broaddus, Aña Lluch, Samuel Aparício, Powel H. Brown, Lajos Pusztai, W. Fraser Symmans, Jan Alsner, Jens Overgaard, Anne‐Lise Børresen‐Dale, Gabriel N. Hortobágyi, Kevin R. Coombes, Gordon B. Mills,
To determine whether functional proteomics improves breast cancer classification and prognostication and can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane and anthracycline-taxane-based systemic therapy (NST). Reverse phase protein array (RPPA) using 146 antibodies to proteins relevant to breast cancer was applied to three independent tumor sets. Supervised clustering to identify subgroups and prognosis in surgical excision specimens from a training set (n = 712) ...
Tópico(s): Advanced Proteomics Techniques and Applications
2011 - BioMed Central | Clinical Proteomics
Ana M. González-Angulo, Bryan T. Hennessy, Gordon B. Mills,
The development of cost-effective technologies able to comprehensively assess DNA, RNA, protein, and metabolites in patient tumors has fueled efforts to tailor medical care. Indeed validated molecular tests assessing tumor tissue or patient germline DNA already drive therapeutic decision making. However, many theoretical and regulatory challenges must still be overcome before fully realizing the promise of personalized molecular medicine. The masses of data generated by high-throughput technologies ...
Tópico(s): Genetics, Bioinformatics, and Biomedical Research
2010 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Todd W. Miller, Marianela Pérez-Torres, Archana Narasanna, Marta Guix, Olle Stål, Gizeh Pérez‐Tenorio, Ana M. González-Angulo, Bryan T. Hennessy, Gordon B. Mills, J. Phillip Kennedy, Craig W. Lindsley, Carlos L. Arteaga,
Knockdown of the tumor suppressor phosphatase Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) with shRNA in three estrogen receptor (ER)-positive breast cancer cell lines resulted in increased phosphatidylinositol-3 kinase (PI3K) and AKT activities, resistance to tamoxifen and fulvestrant, and hormone-independent growth. PTEN knockdown induced the up-regulation of ER transcriptional activity in MCF-7 cells but decreased ER protein levels and transcriptional activity in T47D and MDA- ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2009 - American Association for Cancer Research | Cancer Research
Yi Chen, Natalia Guggisberg, Mercé Jordá, Ana M. González-Angulo, Bryan T. Hennessy, Gordon B. Mills, Chen-Keat Tan, Joyce M. Slingerland,
Abstract Purpose: Antiestrogens are used to treat estrogen receptor (ER)-α-positive breast cancers and cause a p27-dependent G1 arrest. Estrogen-bound ER recruits Src to mediate proteolysis of p27 and drive cell proliferation. Here, we tested the antitumor efficacy of combined Src and aromatase inhibition for ER-positive breast cancer. Experimental Design: Antiproliferative effects of the aromatase inhibitor, anastrozole, and Src inhibitor, AZD0530, alone or in combination were tested in vitro and ...
Tópico(s): FOXO transcription factor regulation
2009 - American Association for Cancer Research | Clinical Cancer Research
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice André, Attila Tordai, Jaime Mejia, W. Fraser Symmans, Ana M. González-Angulo, Bryan T. Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobágyi, Lajos Pusztai,
Purpose Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression. In this study, we compared response to neoadjuvant chemotherapy and survival between patients with TNBC and non-TNBC. Patients and Methods Analysis of a prospectively collected clinical database was performed. We included 1,118 patients who received neoadjuvant chemotherapy at M.D. Anderson Cancer Center for stage ...
Tópico(s): Breast Lesions and Carcinomas
2008 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Ana M. González-Angulo, Bryan T. Hennessy, Kristine Broglio, Funda Meric‐Bernstam, Massimo Cristofanilli, Sharon H. Giordano, Thomas A. Buchholz, Ayşegül A. Şahin, S. Eva Singletary, Aman U. Buzdar, Gabriel N. Hortobágyi,
Abstract The purpose of this study was to evaluate whether the survival of women with inflammatory breast cancer (IBC) treated at our institution has improved over the past 30 years. Three-hundred ninety-eight patients with IBC were treated between 1974 and 2005. Patient characteristics and outcomes were tabulated and compared among decades of diagnosis. Survival outcomes were estimated with the Kaplan-Meier product limit method and compared among groups with the log-rank statistic. Cox proportional ...
Tópico(s): Esophageal Cancer Research and Treatment
2007 - AlphaMed Press | The Oncologist
María Gabriela Castillo Benavides, Daniela Alejandra Caicedo Gallardo, J. Angulo, Bryan Vicente Ramírez Correa,
La tuberculosis, es la infección oportunista más común que se manifiesta entre las personas que viven con el virus de inmunodeficiencia humana (VIH), incluidas las que reciben tratamiento antirretroviral, y es la principal causa de muertes relacionadas con el VIH. Hasta 2015, el continente americano continuaba en la segunda posición a nivel mundial respecto a la carga más alta de coinfección tuberculosis/virus de la inmunodeficiencia humana (TB/VIH), Esta revisión bibliográfica tiene como objetivo ...
Tópico(s): HIV/AIDS oral health manifestations
2019 - | RECIMUNDO
Todd W. Miller, EM Fox, Ana M. González-Angulo, Bryan T. Hennessy, Gordon B. Mills, Eliot T. McKinley, H. Charles Manning, Carlos L. Arteaga,
Abstract ER+ breast cancers typically respond to treatment with aromatase inhibitors (AIs), but a significant fraction exhibit de novo or acquired resistance. To model AI resistance, we cultured four ER+, hormone-dependent human breast cancer cell lines under hormone-depleted conditions for several months until hormone-independent populations emerged (termed long-term estrogen-deprived, LTED). LTED cells outgrew parental counterparts under hormone-depleted conditions. While two LTED lines showed increased ...
Tópico(s): Advanced Breast Cancer Therapies
2009 - American Association for Cancer Research | Cancer Research
C-R Pradeep, Wolfgang J. Köstler, Mattia Lauriola, Roy Z. Granit, F Zhang, Jasmin Jacob–Hirsch, Gidi Rechavi, Hareesh B. Nair, Bryan T. Hennessy, Ana M. González-Angulo, Rajeshwar R. Tekmal, Ittai Ben‐Porath, G.B. Mills, Eytan Domany, Yosef Yarden,
A large fraction of ductal carcinoma in situ (DCIS), a non-invasive precursor lesion of invasive breast cancer, overexpresses the HER2/neu oncogene. The ducts of DCIS are abnormally filled with cells that evade apoptosis, but the underlying mechanisms remain incompletely understood. We overexpressed HER2 in mammary epithelial cells and observed growth factor-independent proliferation. When grown in extracellular matrix as three-dimensional spheroids, control cells developed a hollow lumen, but HER2- ...
Tópico(s): Developmental Biology and Gene Regulation
2011 - Springer Nature | Oncogene
Todd W. Miller, Bryan T. Hennessy, Ana M. González-Angulo, Emily M. Fox, Gordon B. Mills, Heidi Chen, Catherine Higham, Carlos Garcı́a-Echeverrı́a, Yu Shyr, Carlos L. Arteaga,
Many breast cancers exhibit a degree of dependence on estrogen for tumor growth. Although several therapies have been developed to treat individuals with estrogen-dependent breast cancers, some tumors show de novo or acquired resistance, rendering them particularly elusive to current therapeutic strategies. Understanding the mechanisms by which these cancers develop resistance would enable the development of new and effective therapeutics. In order to determine mechanisms of escape from hormone ...
Tópico(s): HER2/EGFR in Cancer Research
2010 - American Society for Clinical Investigation | Journal of Clinical Investigation
Bryan T. Hennessy, Ana M. González-Angulo, Mark Carey, Gordon B. Mills,
Abstract In this issue of Clinical Cancer Research, Andre et al. apply high-resolution arrays to elucidate copy number anomalies in breast cancer. They identify distinct copy number anomaly patterns in different breast cancer subtypes that implicate a number of genes as potential therapeutic targets and as potential markers of therapy responsiveness.
Tópico(s): Cancer Cells and Metastasis
2009 - American Association for Cancer Research | Clinical Cancer Research
Bryan T. Hennessy, Ana-Maria Gonzalez-Angulo, Katherine Stemke‐Hale, Michael Z. Gilcrease, Savitri Krishnamurthy, Ju‐Seog Lee, Jane Fridlyand, Ayşegül A. Şahin, Roshan Agarwal, Corwin Joy, Wenbin Liu, David Stivers, Keith Baggerly, Mark Carey, Aña Lluch, Carlos Monteagudo, Xiaping He, Victor Weigman, Huihui Fan, Juan Palazzo, Gabriel N. Hortobágyi, Laura K. Nolden, Nicholas J. Wang, Vicente Valero, Joe W. Gray, Charles M. Perou, Gordon B. Mills,
Metaplastic breast cancers (MBC) are aggressive, chemoresistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and relatedness to other breast cancer subtypes, 28 MBCs were compared with common breast cancers using comparative genomic hybridization, transcriptional profiling, and reverse-phase protein arrays and by sequencing for common breast cancer mutations. MBCs showed unique DNA copy number aberrations compared with common breast cancers. PIK3CA mutations ...
Tópico(s): Cancer Cells and Metastasis
2009 - American Association for Cancer Research | Cancer Research
Bryan T. Hennessy, Ana M. González-Angulo, Gabriel N. Hortobágyi, Massimo Cristofanilli, Shu Wan Kau, Kristine Broglio, Bruno D. Fornage, S. Eva Singletary, Ayşegül A. Şahin, Aman U. Buzdar, Vicente Valero,
Abstract BACKGROUND Breast carcinoma axillary lymph node (ALN) pathologic complete response (pCR) after primary chemotherapy is associated with significantly higher recurrence‐free survival (RFS) and overall survival (OS) rates. The purpose of the current study was to determine long‐term outcome in patients achieving a pCR of cytologically proven inflammatory breast carcinoma ALN metastases after primary chemotherapy. METHODS Patients with cytologically documented ALN metastases from inflammatory breast ...
Tópico(s): Metastasis and carcinoma case studies
2006 - Wiley | Cancer
Adel Tabchy, Bryan T. Hennessy, Ana M. González-Angulo, F. Meric Bernstam, Yiling Lu, Gordon B. Mills,
Much progress has recently been made in the genomic and transcriptional characterization of tumors. However, historically the characterization of cells at the protein level has suffered limitations in reproducibility, scalability and robustness. Recent technological advances have made it possible to accurately and reproducibly portray the global levels and active states of cellular proteins. Protein microarrays examine the native post-translational conformations of proteins including activated phosphorylated ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2011 - Prous Science | Drugs of today
Bryan Acosta‐Angulo, José A. Lara-Ramos, Jennyfer Diaz‐Angulo, Miguel Ángel Mueses, Fiderman Machuca‐Martínez,
This work focused on estimating the rate constants for three ozone-based processes applied in the degradation of diclofenac. The ozonation (Oz) and its intensification with catalysis (COz) and photocatalysis (PCOz) were studied. Three mathematical models were evaluated with a genetic algorithm (GA) to find the optimal values for the kinetics constants. The Theil inequality coefficient (TIC) worked as a criterion to assess the models’ deviation. The diclofenac consumption followed a slow kinetic regime ...
Tópico(s): Atmospheric chemistry and aerosols
2021 - Multidisciplinary Digital Publishing Institute | Water
Bryan T. Hennessy, Ana M. González-Angulo, Gabriel N. Hortobágyi,
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2005 - Nature Portfolio | Nature Clinical Practice Oncology
Sherene Loi, Benjamin Haibe‐Kains, Samira Majjaj, Françoise Lallemand, Virginie Durbecq, Denis Larsimont, Ana M. González-Angulo, Lajos Pusztai, W. Fraser Symmans, Alberto Bardelli, Peter Ellis, Andrew Tutt, Cheryl Gillett, Bryan T. Hennessy, Gordon B. Mills, Wayne A. Phillips, Martine Piccart, Terence P. Speed, Grant A. McArthur, Christos Sotiriou,
PIK3CA mutations are reported to be present in approximately 25% of breast cancer (BC), particularly the estrogen receptor–positive (ER+) and HER2-overexpressing (HER2+) subtypes, making them one of the most common genetic aberrations in BC. In experimental models, these mutations have been shown to activate AKT and induce oncogenic transformation, and hence these lesions have been hypothesized to render tumors highly sensitive to therapeutic PI3K/mTOR inhibition. By analyzing gene expression and protein ...
Tópico(s): Advanced Breast Cancer Therapies
2010 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Bryan T. Hennessy, Yiling Lu, Ana M. González-Angulo, Mark Carey, Simen Myhre, Zhenlin Ju, Michael A. Davies, Wenbin Liu, Kevin R. Coombes, Funda Meric‐Bernstam, Isabelle Bedrosian, Mollianne J. McGahren, Roshan Agarwal, Fan Zhang, Jens Overgaard, Jan Alsner, Richard M. Neve, Wen-Lin Kuo, Joe W. Gray, Anne‐Lise Børresen‐Dale, Gordon B. Mills,
Abstract Introduction The lack of large panels of validated antibodies, tissue handling variability, and intratumoral heterogeneity potentially hamper comprehensive study of the functional proteome in non-microdissected solid tumors. The purpose of this study was to address these concerns and to demonstrate clinical utility for the functional analysis of proteins in non-microdissected breast tumors using reverse phase protein arrays (RPPA). Methods Herein, 82 antibodies that recognize kinase and ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2010 - BioMed Central | Clinical Proteomics
Bryan Acosta‐Angulo, Jennyfer Diaz‐Angulo, José A. Lara-Ramos, Ricardo A. Torres-Palma, Diana Martínez‐Pachón, Alejandro Moncayo‐Lasso, Fiderman Machuca‐Martínez,
Abstract A bibliometric analysis of the Scopus database was implemented to assess the spread of two types of evolutionary algorithms (EAs), genetic algorithms (GA) and particle swarm optimization (PSO), on the study of reaction kinetics. Particular attention was given to applications for advanced oxidation processes (AOPs). The collaborations between countries and authors, as well as the keywords co‐occurrences, were investigated. Finally, the Gompertz and Logistic Substitution models (LSM) were employed ...
Tópico(s): Catalytic Processes in Materials Science
2022 - Wiley | ChemElectroChem
Shaheenah Dawood, Kristine Broglio, Shu‐Wan Kau, Marjorie C. Green, Sharon H. Giordano, Funda Meric‐Bernstam, Thomas A. Buchholz, Constance T. Albarracin, Wei Yang, Bryan T. Hennessy, Gabriel N. Hortobágyi, Ana M. González-Angulo,
The goal of this study was to describe the effect of race on pathologic complete response (pCR) rates and survival outcomes in women with triple receptor-negative (TN) breast cancers.Four hundred seventy-one patients with TN breast cancer diagnosed between 1996 and 2005 and treated with primary systemic chemotherapy were included. pCR was defined as no residual invasive cancer in the breast and axillary lymph nodes. Overall survival (OS) and recurrence-free survival (RFS) were estimated using the Kaplan- ...
Tópico(s): Breast Lesions and Carcinomas
2008 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Ana M. González-Angulo, Kirsten M. Timms, Shuying Liu, Huiqin Chen, Jennifer K. Litton, Jennifer Potter, Jerry S. Lanchbury, Katherine Stemke‐Hale, Bryan T. Hennessy, Banu K. Arun, Gabriel N. Hortobágyi, Kim‐Anh Do, Gordon B. Mills, Funda Meric‐Bernstam,
Abstract Purpose: To investigate the incidence of germline and somatic BRCA1/2 mutations in unselected patients with triple-negative breast cancer (TNBC) and determine the prognostic significance of carrying a mutation. Methods: DNA was obtained from 77 TNBC and normal tissues. BRCA1/2 exons/flanking regions were sequenced from tumor and patients classified as mutant or wild type (WT). Sequencing was repeated from normal tissue to identify germline and somatic mutations. Patient characteristics were ...
Tópico(s): DNA Repair Mechanisms
2011 - American Association for Cancer Research | Clinical Cancer Research
Chad J. Creighton, Xiaoyong Fu, Bryan T. Hennessy, Angelo Casà, Yiqun Zhang, Ana M. González-Angulo, Aña Lluch, Joe W. Gray, Powell H Brown, Susan G. Hilsenbeck, C. Kent Osborne, Gordon B. Mills, Adrian V. Lee, Rachel Schiff,
Accumulating evidence suggests that both levels and activity of the estrogen receptor (ER) and the progesterone receptor (PR) are dramatically influenced by growth-factor receptor (GFR) signaling pathways, and that this crosstalk is a major determinant of both breast cancer progression and response to therapy. The phosphatidylinositol 3-kinase (PI3K) pathway, a key mediator of GFR signaling, is one of the most altered pathways in breast cancer. We thus examined whether deregulated PI3K signaling in ...
Tópico(s): Metabolism, Diabetes, and Cancer
2010 - BioMed Central | Breast Cancer Research
Maicol Cortez, Bryam López, Bryan Angulo, Milagros Palomino, Carlos Mancha,
Abstract Background This case report highlights the conduction disorder anomalies associated with dengue infection, particularly bradyarrhythmias due to dysfunction of the sinus node and atrioventricular node, which may require cardiac stimulation such as pacemaker implantation. This case emphasizes the importance of continuous monitoring and the use of additional diagnostic techniques to detect complications in a timely manner. Case Summary A 31-year-old male patient was admitted to our institution ...
Tópico(s): Viral Infections and Immunology Research
2024 - Oxford University Press | European Heart Journal - Case Reports
Diego Ricardo Páez Ardila, Sergio Bayona Gómez, Laura Milena Parra Navarro,
... posturales se determinaron mediante la integracion de los angulos de Tait-Bryan recogidos de siete sensores inerciales distribuidos en el ...
Tópico(s): Sports Performance and Training
2018 - Universidad Santo Tomás | Ustasalud
Funda Meric‐Bernstam, Huiqin Chen, Argun Akçakanat, Kim‐Anh Do, Aña Lluch, Bryan T. Hennessy, Gabriel N. Hortobágyi, Gordon B. Mills, Ana M. González-Angulo,
Abstract Introduction Translation initiation is activated in cancer through increase in eukaryotic initiation factor 4E (eIF4E), eIF4G, phosphorylated eIF4E-binding protein (p4E-BP1) and phosphorylated ribosomal protein S6 (pS6), and decreased programmed cell death protein 4 (pdcd4), a translational inhibitor. Further, translation elongation is deregulated though alterations in eukaryotic elongation factor 2 (eEF2) and eEF2 kinase (eEF2K). We sought to determine the association of these translational ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2012 - BioMed Central | Breast Cancer Research
Ana M. González-Angulo, Katherine Stemke‐Hale, Shana L. Palla, Mark Carey, Roshan Agarwal, Funda Meric-Berstam, Tiffany A. Traina, Clifford A. Hudis, Gabriel N. Hortobágyi, William L. Gerald, Gordon B. Mills, Bryan T. Hennessy,
Abstract Purpose: To examine the androgen receptor (AR) levels in breast cancer and to assess the impact of AR expression on patient outcomes. Experimental Design: Reverse-phase protein arrays were used to measure AR levels and a mass spectroscopy–based approach was used to detect PIK3CA mutations. Means and SDs were generated for AR levels. Linear regression models were used to determine if AR levels differed by tumor subtype and PIK3CA mutation status. Two-sample t tests were used to identify pair- ...
Tópico(s): Cancer Genomics and Diagnostics
2009 - American Association for Cancer Research | Clinical Cancer Research
Katrien Berns, Hugo M. Horlings, Bryan T. Hennessy, Mandy Madiredjo, E. Marielle Hijmans, Karin Beelen, Sabine C. Linn, Ana M. González-Angulo, Katherine Stemke‐Hale, Michael Hauptmann, Roderick L. Beijersbergen, Gordon B. Mills, Marc J. van de Vijver, René Bernards,
A large-scale RNA interference screen to discover genes involved in trastuzumab resistance in breast cancer identified only PTEN as a modulator of drug sensitivity. Oncogenic mutants of PIK3CA (activator of the same pathway and frequently mutated in breast cancer) also conferred resistance to trastuzumab in cell culture. In a cohort of 55 breast cancer patients, activation of the PI3K pathway, as judged by the presence of oncogenic PIK3CA mutations or low PTEN expression, was associated with poor ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2007 - Cell Press | Cancer Cell
Bryan Acosta‐Angulo, José A. Lara-Ramos, A. Niño-Vargas, Jennyfer Diaz‐Angulo, Jaime Benavides, Arghya Bhattacharya, Sylvain G. Cloutier, Fiderman Machuca‐Martínez,
In this study, neural networks and support vector regression (SVR) were employed to predict the degradation over three pharmaceutically active compounds (PhACs): Ibuprofen (IBP), diclofenac (DCF), and caffeine (CAF) within a stirred reactor featuring a flotation cell with two non-concentric ultraviolet lamps. A total of 438 datapoints were collected from published works and distributed into 70% training and 30% test datasets while cross-validation was utilized to assess the training reliability. The ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2024 - Elsevier BV | Chemosphere
Robert Angulo, Bryan Herrera, Keila Ibarra,
Prostate cancer is a disease in which malignant (cancer) cells form in the tissues of the prostate. Prostate tumors were responsible for nearly six thousand deaths in Spain in 2016 as the symptoms are very silent and appear like advanced cancer or when this cancer has proliferated to other organs and senses. Therefore, there are 4 characteristic stages of this type of cancer that are classified according to their extension in the body. To make the diagnosis of this type of disease there are methods ...
Tópico(s): Tannin, Tannase and Anticancer Activities
2019 - Universidad Católica de Oriente | Bionatura