Xiang Wu, Shen Yu, Shuang Shen, Wenlong Liu,
The vestibular receptor of cupula acts an important role in maintaining body balance. However, the cupula buried in the semicircular canals (SCCs) will be destroyed ... the relevant environment. The mechanical properties of human cupula still remain ambiguous. In this paper, we explored the cupula responses changing with temperature by experiments and numerical ... 1 °C, which corresponded to the reduction of cupula deformation by 0.3-0.8 μm in ... of endolymphatic properties induced by temperature reduction on cupula deformation through numerical simulation. We found that the ...
Tópico(s): Neurobiology and Insect Physiology Research
2021 - Nature Portfolio | Scientific Reports
Jana Goyens, M.J.B.M. Pourquié, Christian Poelma, Jerry Westerweel,
... fluid which deforms a gelatinous sensory structure (the cupula). We constructed computer models that include both the endolymph flow (using CFD modelling), the cupula deformation (using FEM modelling), and the interaction between ... initial time steps, both the displacement of the cupula and its restorative forces are still small. As a result, the endolymph vortex causes the cupula to deform asymmetrically in an S-shape. The asymmetric deflection increases the cupula strain near the crista and, as a result, ...
Tópico(s): Ear Surgery and Otitis Media
2019 - Springer Science+Business Media | Biomechanics and Modeling in Mechanobiology
... geotropic positional nystagmus is due to a light cupula, heavy cupula produces apogeotropic positional nystagmus, and canalolithiasis accounts for ... 3 subtypes. Methods Subjects were patients with light cupula ( n = 47), heavy cupula ( n = 48), and canalolithiasis ( n = 45). We investigated ... the first visit. The recurrence rate of light cupula group was 72.3%, that of heavy cupula group was 20.8%, and that of canalolithiasis ... the number of times of recurrence in light cupula group was 2.5 ± 1.3 times, that in heavy cupula group was 1.5 ± 0.7 times, and ...
Tópico(s): Glaucoma and retinal disorders
2019 - Elsevier BV | Auris Nasus Larynx
Xiaowu Tang, Qiuhong Huang, Ling Chen, Peng Liu, Tianci Feng, Yongkang Ou, Yiqing Zheng,
... apogeotropic and was considered as "cupulolithiasis or heavy cupula. " Recently, the concept of "light cupula" exhibiting persistent geotropic DCPN has been introduced. However, the light cupula is not systematically described, while the identification and diagnosis of "light cupula" should be improved. Here we investigated the underlying ... therapeutic options designed to the "light" and "heavy" cupula, respectively; and summarized the clinical characteristics and therapeutic ... nystagmus, we further divided the patients into "heavy cupula" (apogeotropic) and "light cupula" (geotropic) groups. We compared ...
Tópico(s): Ophthalmology and Eye Disorders
2019 - Frontiers Media | Frontiers in Neurology
Pierre Selva, Charles M. Oman, Howard A. Stone,
The mathematical model for the dynamics of the cupula-endolymph system of the inner ear semicircular canal, ... all of vestibular physiology. Most models represent the cupula as a linear spring-like element of stiffness ... directly influences the long time constant of the cupula-endolymph system. Given estimates of K based on ... also finite-element simulations based on more realistic cupula morphologies, to estimate the human cupula's Young's modulus E approximately 5.4 ... that the morphology of the attachment of the cupula to the slope of the crista should not ...
Tópico(s): Underwater Acoustics Research
2010 - IOS Press | Journal of Vestibular Research
Ujimoto Konomi, Mamoru Suzuki, Koji Otsuka, Akira Shimizu, Taro Inagaki, Go Hasegawa, Shigetaka Shimizu, Rei Motohashi,
Conclusion: The cupula shows various degrees of changes after gentamicin (GM) injection into the inner ear, with or without damage of the sensory cells. This cupula change may be a part of the etiology ... Objectives: To observe the morphological changes of the cupula after injecting GM in the frog inner ear and to compare the changes of the cupula with those of the ampullary sensory cells. Methods: ... SEM). The correlation between the changes in the cupula and sensory cells was evaluated using our own ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2009 - Taylor & Francis | Acta Oto-Laryngologica
Edward R. Damiano, Richard D. Rabbitt,
... field in a fluid boundary layer surrounding the cupula. The governing equations were linearized for small perturbations ... condition acting on the two surfaces of the cupula. In this sense, the analysis reduces the three- ... boundary condition acting on the surfaces of the cupula. For illustrative purposes we present specific results modelling the cupula as a simple viscoelastic membrane. New results show ... significant influence on the pointwise deflection of the cupula near the crista. The spatially averaged displacement of ...
Tópico(s): Underwater Acoustics Research
1996 - Cambridge University Press | Journal of Fluid Mechanics
James P. Kelly, Sietse M. van Netten,
Abstract The cupula of the supraorbital neuromast in the lateral line canal of the clown knifefish contains vertical columns. In the central region of the cupula overlying the macula, these columns are densely packed, ... size, and run from the base of the cupula to the surface of the cupula which is exposed to canal fluid. There are ... of section that cut across the columns; the cupula therefore has the appearance of mosaic tile in ... tubules that extend from the base of the cupula at the junction with the macula to the ...
Tópico(s): Marine animal studies overview
1991 - Wiley | Journal of Morphology
Charles M. Oman, Laurence R. Young,
... of what constitutes the “physiologic” behavior of the cupula has been the subject of debate for some time. Calculations are presented which suggest that the cupula constitutes a biological pressure transducer with a threshold ... would probably be extremely easy to traumatize the cupula by exposing it to pressure gradients far beyond ... the course of experimental preparations intended to visualize cupula motion. An estimate of the dynamic range of cupula motion may also be obtained which indicates that ...
Tópico(s): Cardiovascular and Diving-Related Complications
1972 - Taylor & Francis | Acta Oto-Laryngologica
Charles M. Oman, Laurence R. Young,
... of what constitutes the “physiologic” behavior of the cupula. Considerations based on calculation of the moment of ... angular accelerations suggest that the pressure across the cupula associated with behavioral thresholds must be less than ... canals, and involve no assumptions with respect to cupula stiffness or cupula drag. The cupula constitutes of a biological pressure transducer with a ... it would be extremely easy to traumatize the cupula structure by exposing it to pressure gradients far ... the course of experimental preparations intended to visualize cupula motion. An estimate of the range of cupula ...
Tópico(s): Motor Control and Adaptation
1972 - Elsevier BV | Progress in brain research
... or not in patients with heavy or light cupula.Prospective case series.The subjects were 19 patients with heavy cupula (3 males, 16 females; mean age, 62.8 years) and 14 patients with light cupula (5 males, 9 females; mean age, 63 years). ... slow-phase velocity and calculated asymmetry.In heavy cupula group, no one revealed canal paresis (CP) and ... is greater than healthy ear response). In light cupula group, 3 patients (21%) revealed CP.Dysfunction of ... canal does not always remain in either heavy cupula or light cupula. The caloric response increases in ...
Tópico(s): Glaucoma and retinal disorders
2016 - Wiley | Laryngoscope Investigative Otolaryngology
Chang‐Hee Kim, Jung Eun Shin, Yong Won Kim,
... simple method of evaluating patients with cupulopathy (light cupula and heavy cupula), which is performed in a seated position, and ... evaluated in 26 patients with cupulopathy (five light cupula and 21 heavy cupula). The diagnosis of cupulopathy was confirmed with the ... was directed toward the ipsilesional side in heavy cupula and the contralesional side in light cupula. The first null point was identified when the ... rolling elicited a persistent geotropic DCPN in light cupula patients and persistent apogeotropic DCPN in heavy cupula ...
Tópico(s): Glaucoma and retinal disorders
2015 - Wiley | The Laryngoscope
Chang‐Hee Kim, Jung Eun Shin, Dong Hyuk Shin, Yong Won Kim, Jae Ho Ban,
... the clinic. Recently a concept of the light cupula was introduced, which accounts for some of positional ... condition in which the specific gravity of the cupula is same as that of the surrounding endolymph, ... are not influenced by the gravity. The light cupula, which indicates cupula with lower specific gravity than the surrounding endolymph, ... of positional nystagmus are carefully examined, the light cupula can be misdiagnosed as other types of BPPV. We present a patient with light cupula on the right side who reported recurrent episodes ...
Tópico(s): Glaucoma and retinal disorders
2014 - Elsevier BV | Medical Hypotheses
... to canal-centered head rotation in which the cupula partition is modeled as a poroelastic mixture of ... and fluid constituents. The solid matrix of the cupula is assumed to behave as a linear elastic ... a dynamic boundary condition, which acts across the cupula partition. Numerical solution of the coupled system of ... both the fluid and solid constituents of the cupula. Results indicate that at frequencies above 1 Hz, ... predicted by single-component viscoelastic models of the cupula. Below 1 Hz, the dynamic coupling between the ...
Tópico(s): Underwater Acoustics Research
1999 - ASM International | Journal of Biomechanical Engineering
The cupula has long been regarded as the link between the inertial fluid movements in the canal duct and ... unaffected by position and/or mobility of the cupula. There are, further, indications that contrary to expectation, a direct mechanical deflection of the cupula would have less effect on the nerve response ... of the ampulla, resulting in a reduction in cupula deflection without any evident functional advantage.2) The ... is not directed towards the surface of the cupula, but towards the entrance to the subcupular space. ...
Tópico(s): Vestibular and auditory disorders
1980 - Taylor & Francis | Acta Oto-Laryngologica
Sevda Boran Torun, Emrah Peşman, Ayfer Dönmez Çavdar,
... alkali treatment on the mechanical, physical properties of cupula fibers reinforced recycled high density polyethylene (r‐HDPE) ... were produced with different chestnut ( Castanea sativa Mill.) cupula fiber contents, up to 50%, and polyethylene‐grafted ... to observe the interactions and functional groups between cupula fiber and r‐HDPE in the composite samples. ... values with up to 40 wt% alkali treated cupula fiber loading in polymer matrix compared to that ... crystallinity decreased with the increase of the chestnut cupula fiber ratio. As excepted, the FTIR analysis showed ...
Tópico(s): Mechanical Engineering and Vibrations Research
2019 - Wiley | Polymer Composites
Cupula displacement had traditionally been portrayed as a wiper motion of the cupula hinged at its base. In this study, semicircular ... which had been carefully dissected, were analyzed for cupula motion during compression of the canal wall. Cupulae ... the receptor base while the center of the cupula mass had little movement. Large endolymph displacements produced ... opposite wall. When endolymph was excessively displaced, the cupula became dislodged at its apical end and moved ... the characteristic bulging. It is concluded that the cupula was dislodged in earlier studies by other investigators ...
Tópico(s): Turtle Biology and Conservation
1979 - Elsevier BV | Neuroscience
The general shape of the cupula conformsto the receptor area from which it arises. In the vertical canals of the frog, the cristae have an overall dumbbell shape; the cupula has corresponding enlarged masses which project from the ... that the thinner center reaches the apex.The cupula forms a tight diaphragm across the ampulla which ... to diaphragmatic displacement results. The apex of the cupula is most labile to detachment but not initial ... reached its maximum for the base of the cupula, the apical end is displaced and ultimately detached. ...
Tópico(s): Receptor Mechanisms and Signaling
1974 - Karger Publishers | Brain Behavior and Evolution
María Cecilia Venegas-Arques, Carolina Pia Rojas-García, Yuri Andrés Cataldo-Saavedra, Paula Fernanda Jiménez-Gomez, Victoria Inés Arqués-Vergara, Benjamín Martinez,
... aislamiento absoluto, con y sin uso de una cúpula de acrílico, puesta en un paciente sano. Las ... promedio de 8.1 UFC en Box sin cúpula y 3,9 UFC en el box con cúpula, encontrándose diferencia estadísticament e significativa (p= 0,0391). ... ambientales 28,33 UFC en el Box con cúpula, 29 UFC en el Box control y Box sin cúpula 46, 66 UFC. Al comprobar que la cúpula de acrílico contiene eficazmente los aerosoles, corresponde utilizarlo ...
Tópico(s): Public Health and Environmental Issues
2021 - | International journal of odontostomatology
Carla Santos, J. Belinha, Fernanda Gentil, Marco Parente, Renato Natal Jorge,
The cupula is a part of the inner ear semi-circular canals that plays an important role in the ... order to understand the dynamic response of the cupula, first it is necessary to obtain its vibration ... dimensional and three-dimensional geometrical model of the cupula was built. Then, a free vibration analysis was ... studied, aiming to analyze the environment of the cupula (in healthy and pathologic scenarios). The results obtained ... study on the free vibration analysis of the cupula and shows an alternative numerical technique to calculate ...
Tópico(s): Numerical methods in engineering
2018 - Elsevier BV | Engineering Analysis with Boundary Elements
Meghali Bora, Ajay Giri Prakash Kottapalli, J.M. Miao, Michael Triantafyllou,
... and material properties of specialized structures like a cupula would significantly help to improve the existing designs. ... sensor and investigates the role of a biomimetic cupula in influencing the performance of the sensor. The ... the steady-state and oscillatory flows. An artificial cupula was synthesized using a soft hydrogel material and ... and mechanical properties. Results show that the artificial cupula had a porous structure and high mechanical strength ... output was detected in the presence of the cupula structure. This is the first time a MEMS ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2017 - American Institute of Physics | APL Materials
Tatjana Tomanovic, Johan Bergenius,
... pattern compatible with a condition of a light cupula in the lateral semicircular canal seen in clinical ... 1).To mimic the condition of a light cupula in the lateral semicircular canal by using unilaterally ... results with those of patients with a light cupula.Five hemi-labyrinthectomized subjects were studied during PAN ... supine positions, respectively. A zero zone, indicating a cupula dysfunction, in which the geotropic nystagmus changed direction ... pattern was compatible with that of a light cupula. However, the nystagmus directions at the head straight ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2011 - Taylor & Francis | Acta Oto-Laryngologica
Youichi Iimura, Mamoru Suzuki, Koji Otsuka, Taro Inagaki, Ujimoto Konomi, Shigetaka Shimizu,
Conclusion: With half-sized cupula, the semicircular canal nerve potentials decreased under slow stimulus, thus potentially leading to reduced caloric response. This also suggests that shrunken cupula may cause dizziness because of its hypermobility. Objectives: To examine the physiological effect of half-sized cupula on the semicircular canal nerve potential. Methods: The isolated cupula of the bullfrog was sectioned in half with ... the evoked action potentials were recorded. Results: The cupula was successfully sectioned in half and was replaced ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2010 - Taylor & Francis | Acta Oto-Laryngologica
Richard D. Rabbitt, Kathryn D. Breneman, Curtis S. King, Angela M. Yamauchi, Richard Boyle, Stephen M. Highstein,
The dynamic displacement of the semicircular canal cupula and modulation of afferent nerve discharge were measured simultaneously in response to physiological stimuli in vivo. The adaptation time constant(s) of normal ... displacement gain of the central region of the cupula averaged 53 nm per deg/s. Afferents adapted more rapidly than the cupula, demonstrating the presence of a relaxation process that ... also investigated changes in time constants of the cupula and afferents following detachment of the cupula at ...
Tópico(s): Ophthalmology and Eye Disorders
2009 - Springer Science+Business Media | Journal of the Association for Research in Otolaryngology
A.V. Kondrachuk, S. P. Sirenko, R. Boyle,
The effect of different densities of a cupula and endolymph on the dynamics of the semicircular canals is considered within the framework of a simplified one-dimensional mathematical model where the ... to the canal plane. The difference of the cupula and endolymph densities reveals new features of cupula dynamics, for instance--a shift of the cupula to a new position of equilibrium that depends ... parameters of head rotation, and the onset of cupula oscillations with multiple frequencies that results in the ...
Tópico(s): Visual perception and processing mechanisms
2008 - IOS Press | Journal of Vestibular Research
The functional significance of the ciliary interconnections and cupula has been reviewed. The ciliary interconnecting systems are ... shafts, are actually involved in mechanoelectrical transduction. The cupula is composed of the cupula and subcupular meshwork. The subcupular meshwork consists of ... branching filaments cross-bridged to one another. The cupula would function as a rigid plate and equally distribute the shear force of the cupula to all the ciliary bundles. The subcupular meshwork ... transmission of the shear strain force of the cupula to the ciliary bundle and may also exert ...
Tópico(s): Oral and Maxillofacial Pathology
2001 - | Biological Sciences in Space
Charles M. Oman, Lawrence S. Frishkopf, Moïse H. Goldstein,
... upper bound on the magnitude of semicircular canal cupula motion was experimentally determined in the isolated labyrinth of the skate, Raja erinacea To visualize the cupula, a glass pipette was pushed through the ampullary wall, and local regions of the cupula were stained by slow infusion of small amounts ... silent units were found to produce no detectable cupula motion as seen through the ampulla wall. However when the cupula was first grossly displaced, motion was thereafter observed ... afferent responses indicates that the normal range of cupula motion in the skate is below the optical ...
Tópico(s): Lipid Membrane Structure and Behavior
1979 - Taylor & Francis | Acta Oto-Laryngologica
Chang‐Hee Kim, Ngoc Chien Pham,
Light cupula is an emerging concept accounting for positional nystagmus. It can be diagnosed when persistent geotropic direction-changing ... a head-roll test. Although hypotheses explaining light cupula phenomenon such as "light debris", "lighter cupula", and "heavier endolymph" have been proposed, the mechanism underlying light cupula has not been clearly elucidated yet. In the ... we proposed a new hypothesis accounting for light cupula, i.e., density difference between perilymph and endolymph ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2018 - Elsevier BV | Medical Hypotheses
Jung Eun Shin, Kyung‐Hwa Jeong, Sung Hwan Ahn, Chang‐Hee Kim,
... with spontaneous detachment of otoliths from the LSCC cupula, and to confirm that otoliths may adhere to both the utricle and canal sides of the cupula. Patients and methods Using video nystagmography, positional nystagmus ... either cupulolithiasis on the right side or light cupula on the left side of the LSCC. In ... from the canal side of the right LSCC cupula. In Case 2, vigorous right-beating nystagmus was ... attached on utricle side of the right LSCC cupula were detached and fell into the utricle under ...
Tópico(s): Venomous Animal Envenomation and Studies
2016 - Elsevier BV | Auris Nasus Larynx
Ajay Giri Prakash Kottapalli, Meghali Bora, Mohsen Asadnia, Jianmin Miao, Subbu S. Venkatraman, Michael Triantafyllou,
... resolution through a biomimetic hyaulronic acid-based hydrogel cupula dressing. The inspiration comes from the spatially distributed ... the formation of a prolate spheroid-shaped artificial cupula. Rheological and nanoindentation characterizations showed that the Young's modulus of the artificial cupula closely matches the biological cupula (10-100 Pa). A comparative experimental study conducted ... of the naked hair cell sensor and the cupula-dressed sensor in sensing steady-state flows demonstrated ... 5 times due to the presence of hydrogel cupula. The novel strategies of sensor development presented in ...
Tópico(s): Surface Modification and Superhydrophobicity
2016 - Nature Portfolio | Scientific Reports