Halil İbrahim Yakut, Ece Koyuncu, Ufuk Çakır, Cüneyt Tayman, İsmail Koyuncu, Tuğba Taşkın Türkmenoğlu, Esra Çakır, Ahmet Özyazıcı, Seda Aydoğan, Ayşegül Zenciroğlu,
We aimed to understand the efficacy of fennel (Foeniculum vulgare: FV) extract in an experimental necrotizing enterocolitis (NEC) model. Forty-two rat pups were divided into three groups as NEC, NEC treated with fennel extract, and control. At the end of the experiment, tissue samples were taken from the proximal colon and ileum for biochemical and immuno-histological studies including hematoxylin-eosin and Caspase-3-8-9 immunohistochemical staining. Bowel damage and apoptosis were found to be less ...
Tópico(s): Child Nutrition and Water Access
2020 - Wiley | Journal of Food Biochemistry
Ufuk Çakır, Cüneyt Tayman, Utku Serkant, Halil İbrahim Yakut, Esra Çakır, Ufuk Ateş, İsmail Koyuncu, Eyyüp Karaoğul,
Necrotizing enterocolitis (NEC) is the most important gastrointestinal emergency affecting especially preterm infants and causes severe morbidities and mortality. However, there is no cure. Oxidant stress, inflammation, apoptosis, as well as prematurity are believed to responsible in the pathogenesis of the disease. Ginger and its compounds have anti-inflammatory, antimicrobial, anti-oxidant properties and immunomodulatory, cytoprotective/regenerative actions. This study aimed to evaluate the beneficial ...
Tópico(s): Pregnancy and Medication Impact
2018 - Elsevier BV | Journal of Ethnopharmacology
Şehribanu Işık, Cüneyt Tayman, Ufuk Çakır, İsmail Koyuncu, Tuğba Taşkın Türkmenoğlu, Esra Çakır,
Leukotrienes, free oxygen radicals, tumor necrosis factor-alpha, and inflammatory mediators play major roles in the development of necrotizing enterocolitis (NEC). Rhus coriaria (RC: sumac) extracts may enhance cell viability by reinforcing defenses against free radical species in several progressive diseases as well as inflammatory diseases. The aim of the present study was to evaluate the effects of RC in a rat NEC model in terms of intestinal damage. Newborn pups were separated into three groups: ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2019 - Wiley | Journal of Food Biochemistry
Cüneyt Tayman, Ufuk Çakır, Hasan Akduman, Şefika Karabulut, Murat Çağlayan,
Lung damage due to hyperoxia and inflammation are important causes of bronchopulmonary dysplasia (BPD). We aimed to investigate the beneficial effects of Apocynin (Apo) on rat pups exposed to hyperoxia and inflammation. Forty-eight rat pups were randomly divided into 3 groups as hyperoxia (95% O2) + lipopolysaccharide (LPS), hyperoxia + LPS + Apo treated and control (21% O2). Rat pups in the Apo group received Apo at a daily dose of 40 mg/kg. Histopathological (Hematoxylin-Eosin, Masson trichrome), immunochemical ( ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2021 - Elsevier BV | International Immunopharmacology
Cüneyt Tayman, Ufuk Çakır, Mehmet Büyüktiryaki, Utku Serkant, Şerife Suna Oğuz, Halit Halil,
Background Diagnosis and treatment of patent ductus arteriosus (PDA) in premature infants is still an important problem for clinicians. Echocardiography is the gold standard for determination of PDA based on clinical and hemodynamic significance. Clinical decision making may be aided by measuring circulating biomarkers such as natriuretic and endothelial propeptides. We aimed to investigate the significance of serum endocan and B-type natriuretic peptide (BNP) in the diagnosis and follow-up of hemodynamically ...
Tópico(s): Infant Development and Preterm Care
2017 - Thieme Medical Publishers (Germany) | American Journal of Perinatology
Ufuk Çakır, Cüneyt Tayman, Ali Ulaş Tuğcu, Duran Yıldız,
The role of systemic inflammatory indices in the diagnosis of bronchopulmonary dysplasia (BPD) is unknown. The aim of the study was to determine the possible clinical utility of systemic inflammatory indices in the prediction of moderate to severe BPD.Premature infants<32 weeks of gestational age were included in the study. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), pan-immune-inflammation value ( ...
Tópico(s): Respiratory Support and Mechanisms
2023 - Elsevier BV | Archivos de Bronconeumología
Ufuk Çakır, Cüneyt Tayman, Çiğdem Yücel,
Background: Bronchopulmonary dysplasia (BPD) is an important clinical problem for premature infants. Previously, some biomarkers associated with severity of BPD have been studied. In our study, we aimed to investigate the value of interleukin-33 (IL-33) levels as a new biomarker in the follow-up of BPD severity and response to treatment. Materials and Methods: Premature infants of <32 weeks of gestational age and birth weight <1,500 g were included in the study. Infants with BPD were divided into moderate ...
Tópico(s): Infant Nutrition and Health
2019 - Mary Ann Liebert, Inc. | Pediatric Allergy Immunology and Pulmonology
Ufuk Çakır, Cüneyt Tayman, Çiğdem Yücel, Özdemir Özdemir,
Retinopathy of Prematurity (ROP) is a pathophysiologic condition of the retina due to abnormal proliferation of retinal vessels.The study aimed too ascertain the importance of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), interleukin-33 (IL-33) and endocan in the diagnosis and follow-up of ROP.This prospective cohort study was conducted in the neonatal intensive care unit (NICU) of Health Science University, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey, ...
Tópico(s): Preterm Birth and Chorioamnionitis
2019 - Bentham Science Publishers | Combinatorial Chemistry & High Throughput Screening
Patent ductus arteriosus (PDA) is an important clinical problem associated with mortality and serious morbidities. It is thought that serum osmolality may affect ductal patency. We aimed to investigate the importance of serum osmolality related to ductal patency in preterm infants.Our study was conducted between January 2013 and December 2017. Premature infants with birth weight <1,500 g and gestational age <32 weeks were included in the study. Serum osmolality was compared between infants with hemodynamically ...
Tópico(s): Mechanical Circulatory Support Devices
2018 - Thieme Medical Publishers (Germany) | American Journal of Perinatology
Ufuk Çakır, Cüneyt Tayman, Erbu Yarcı, Halid Halil, Mehmet Büyüktiryaki, Hülya Özkan Ulu, Çiğdem Yücel, Şerife Suna Oğuz,
Objectives: To ascertain the diagnostic value of endocan and interleukin (IL)-33 in infants with necrotizing enterocolitis (NEC) and to compare their effectiveness with C-reactive protein (CRP) and interleukin-6 (IL-6).Methods: Eighty-four preterm infants including control (n = 42) and NEC (n = 42) were eligible. Blood samples were obtained from infants in the NEC for the assessment of CRP, IL-6, endocan, and IL-33 serum levels at the time of diagnosis (first day), at the third and seventh days of NEC. Endocan, ...
Tópico(s): Child Nutrition and Feeding Issues
2018 - Informa | The Journal of Maternal-Fetal & Neonatal Medicine
Özgür Çakır, Cüneyt Uçarlı, Çağatay Tarhan, Murat Pekmez, Neslihan Turgut Kara,
Legumes are indispensable for human diet in respect to their valuable and nutritive bioactive molecules. Legumes and derivative foodstuffs are rich in fiber, proteins, vitamins and some valuable phytochemicals, which exhibit important biological activities. Due to their remarkable molecular content, they are receiving great attention by researchers. Recent developments in genomics and bioinformatics led to cumulative data about legume genomes. These data could provide important information to accelerate ...
Tópico(s): Botanical Research and Chemistry
2018 - Sociedade Brasileira de Ciência e Tecnologia de Alimentos | Food Science and Technology
Ufuk Çakır, Cüneyt Tayman, Nazmiye Bengü Karaçağlar, Esra Beşer, Burak Ceran, Handan Ünsal,
Tópico(s): Mechanical Circulatory Support Devices
2020 - Springer Science+Business Media | European Journal of Pediatrics
Esra Çakır, Ufuk Çakır, Cüneyt Tayman, Tuğba Taşkın Türkmenoğlu, Ataman Gönel, Işıl Özkoçak Turan,
Background: Activated inflammation and oxidant stress during cerebral ischemia reperfusion injury (IRI) lead to brain damage. Astaxanthin (ASX) is a type of carotenoid with a strong antioxidant effect. Objective: The aim of this study was to investigate the role of ASX on brain IRI. Methods: A total of 42 adult male Sprague-Dawley rats were divided into 3 groups as control (n=14) group, IRI (n=14) group and IRI + ASX (n=14) group. Cerebral ischemia was instituted by occluding middle cerebral artery for ...
Tópico(s): Medicinal Plants and Bioactive Compounds
2020 - Bentham Science Publishers | Combinatorial Chemistry & High Throughput Screening
Hasan Akduman, Cüneyt Tayman, Ufuk Çakır, Esra Çakır, Dílek Díllí, Tuğba Taşkın Türkmenoğlu, Ataman Gönel,
This study aimed to ascertain the effects of astaxanthin on the lungs of rat pups with bronchopulmonary dysplasia (BPD) induced by hyperoxia and lipopolysaccharide (LPS).Forty-two newborn Wistar rats, born to spontaneous pregnant rats, were divided into three groups: Hyperoxia (95% O2) + lipopolysaccharide (LPS) group, hyperoxia + LPS + astaxhantin group, and control: no treatment group (21% O2). Pups in the hyperoxia + LPS + astaxanthin group were given 100 mg/kg/day oral astaxanthin from the first day to the ...
Tópico(s): Birth, Development, and Health
2020 - Bentham Science Publishers | Combinatorial Chemistry & High Throughput Screening
Ufuk Çakır, Cüneyt Tayman, Mehmet Büyüktiryaki,
There is insufficient study of the association of blood groups with neonatal diseases. The aim of this study was to evaluate the blood groups associated with sepsis and blood groups in preterm infants.This retrospective study was conducted between January 1, 2010 and November 31, 2018 in the neonatal intensive care unit (NICU). This study was done in single-center tertiary NICU. Infants born at gestational age (GA) <32 weeks with birth weight (BW) <1,500 g were included in the study.A total of 2,548 ...
Tópico(s): Neonatal and fetal brain pathology
2019 - Thieme Medical Publishers (Germany) | American Journal of Perinatology
Background It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants. Methods Very low birth weight infants (VLBW, 700 IU/L were included in the OOP group. We intended to figure out the relationship between OOP and CH in infants. Results In our study, OOP frequency ...
Tópico(s): Thyroid Disorders and Treatments
2018 - De Gruyter | Journal of Pediatric Endocrinology and Metabolism
Mehmet Büyüktiryaki, Cüneyt Tayman, İsmail Koyuncu, Ufuk Çakır, Tuğba Taşkın Türkmenoğlu, Esra Çakır, Nilüfer Okur,
Necrotizing enterocolitis (NEC) is a major neonatal health problem that especially affects preterm infants and causes severe morbidity and mortality. Although its pathogenesis is not fully understood, important risk factors include prematurity, oxidative stress, inflammation, and apoptosis. Ankaferd Blood Stopper® (ABS) has antioxidant, antiinflammatory, antimicrobial, antiapoptotic, and wound healing accelerant properties. In this study, we aimed to investigate whether treatment with ABS reduced ...
Tópico(s): Infectious Aortic and Vascular Conditions
2018 - Elsevier BV | Biomedicine & Pharmacotherapy
Çiğdem Arıkan, Cüneyt Zihni, Murat Çakır, Murat Alkanat, Sema Aydoğdu,
Tópico(s): Gastrointestinal disorders and treatments
2007 - Springer Science+Business Media | Digestive Diseases and Sciences
Ufuk Çakır, Cüneyt Tayman, Mehmet Büyüktiryaki, Handan Ünsal, Buse Özer Bekmez,
Abstract Objective We investigated the relationship of serum potassium (K+) and ionized calcium (iCa2+) levels with the persistence of ductus arteriosus. Study Design This retrospective cohort study included infants with birth weight < 1,500 g and gestational age < 32 weeks. Serum K+ and iCa2+ levels at the 1st and 48th hour of life were measured from samples. The difference between the two levels was calculated for both serum K+ (ΔK+) and iCa2+ (ΔCa2+). These values were compared between hemodynamically ...
Tópico(s): Neonatal Respiratory Health Research
2019 - Thieme Medical Publishers (Germany) | American Journal of Perinatology
Abbas Ali Tam, Didem Özdemir, Sevgül Fakı, Muhammet Cüneyt Bilginer, Reyhan Ersoy, Bekir Çakır,
Purpose: In this study, we aimed to evaluate ABO blood groups and Rh factor in patients with thyroid cancer.Methods: Demographical and clinical features, cytological results, ABO blood groups, and Rh factor status of patients with benign and malignant thyroid disease were evaluated. Histopathological features of thyroid cancer were compared in Rh positive and negative patients, and patients with different ABO blood groups.Results: Histopathological diagnosis was benign in 1,299 (63.5%) and malignant ...
Tópico(s): Thyroid Disorders and Treatments
2019 - Taylor & Francis | Endocrine Research
Alkım Öden Akman, Fatma Karaca Kara, Tülin Köksal, Bahar Çuhacı Çakır, Cüneyt Karagöl, Tülin Revide Şaylı,
Immunoglobulin therapy can be used to treat a wide variety of diseases. However, intravenous immunoglobin products can cause several adverse reactions, including hemolysis. The objective of this study was to determine the extent of anemia and hemolysis after high dose intravenous immunoglobin (2 g/kg) and its relationship to the ABO blood type system and hemolytic anemia blood parameters in pediatric patients. Incidence of ‘Intravenous immunoglobulin related hemolysis’ was %19 (6/31) after high dose ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2017 - Elsevier BV | Transfusion and Apheresis Science
Selim Kayacı, Tayfun Çakır, Müge Dolgun, Ertuğrul Çakır, Şahin Bozok, Cüneyt Temız, Yusuf Çağlar,
Aortic injury by pedicle screw is rare but can cause serious complications. It has not been clearly determined when aortic repair is necessary in cases of screw impingement without perforation of the aortic wall. In this article, we review the treatment and clinical course of pedicle screw aortic impingement and attempt to clarify this issue. Cases of aortic injury during thoracic screw procedures were found using a MEDLINE search and analyzed together with 3 new cases that we present. Nineteen ...
Tópico(s): Spine and Intervertebral Disc Pathology
2019 - Elsevier BV | World Neurosurgery
Atilla Çifci, Cüneyt Tayman, Halil İbrahim Yakut, Halit Halil, Esra Çakır, Ufuk Çakır, Salih Aydemir,
Background/aim: Hyperoxia- and inflammation-induced lung injury is an important cause of the development of bronchopulmonary dysplasia (BPD) in premature infants. We aimed to ascertain the beneficial effects of ginger (Zingiber officinale) on rat pups exposed to hyperoxia and inflammation. Materials and methods: Thirty-six newborn Wistar rats were randomly divided into 3 groups as the hyperoxia (95% O2) + lipopolysaccharide (LPS) group, the hyperoxia + LPS + ginger-treated group, and the control/no treatment ...
Tópico(s): Pediatric health and respiratory diseases
2018 - Scientific and Technological Research Council of Turkey (TUBITAK) | TURKISH JOURNAL OF MEDICAL SCIENCES
Buse Özer Bekmez, Cüneyt Tayman, Mehmet Büyüktiryaki, Aslıhan Köse Çetinkaya, Ufuk Çakır, Turan Derme,
Background The role of red cell distribution width‐to‐platelet ratio ( RPR ) has not previously been mentioned in reports on patent ductus arteriosus ( PDA ). Our objective was to evaluate whether RPR would have a role in the diagnosis and/or prediction of pharmacological closure of PDA . Methods Preterm infants’ gestational age ≤30 weeks and ≤1500 g who were given first ibuprofen treatment in the first week of life for hemodynamically significant PDA (hs PDA ) were included in the study. The patients were matched ...
Tópico(s): Kawasaki Disease and Coronary Complications
2018 - Wiley | Journal of Clinical Laboratory Analysis
Buse Özer Bekmez, Cüneyt Tayman, Ufuk Çakır, İsmail Koyuncu, Mehmet Büyüktiryaki, Tuğba Taşkın Türkmenoğlu, Esra Çakır,
Tópico(s): Respiratory Support and Mechanisms
2021 - Springer Nature | Pediatric Research
Ali Güngör, Arif İsmet Çatak, Bahar Çuhacı Çakır, Alkım Öden Akman, Cüneyt Karagöl, Tülin Köksal, Halil İbrahim Yakut,
Turkey is the leading country among those that accept Syrian refugees. This study aimed to determine the density of Syrian refugees who received inpatient treatment at Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital between January 2016 and August 2017.Syrian refugees' gender, age, place of birth, duration of hospitalization, admission diagnosis and services required as an inpatient were recorded from the registration system. Admission diagnoses were grouped according ...
Tópico(s): Education and experiences of immigrants and refugees
2018 - Oxford University Press | International Health
Cüneyt Çakir, Emre Turan, Atilla Şimşek,
Tópico(s): Phytochemicals and Antioxidant Activities
2023 - Springer Science+Business Media | Journal of Food Measurement & Characterization
Hüsniye Başer, Oya Topaloğlu, Muhammet Cüneyt Bilginer, Serap Ulusoy, Aydan Kılıçarslan, Elif Özdemir, Reyhan Ersoy, Bekir Çakır,
Abstract Background We aimed to compare the cytology and histopathology results of hot, cold, and warm nodules in patients who had thyroidectomy due to toxic multinodular goiter (TMNG). Methods Five hundred and nine thyroid nodules from 413 patients who had operation with TMNG were included in this retrospective study. The nodules were categorized as hot, cold, and warm groups. The cytology and histopathology results were compared. Results The 509 thyroid nodules were grouped as hot (n = 364 [71.5%]), ...
Tópico(s): Head and Neck Anomalies
2019 - Wiley | Diagnostic Cytopathology
Ufuk Çakır, Ali Ulaş Tuğcu, Cüneyt Tayman, Duran Yıldız,
Objective It is not yet known whether systemic inflammatory indices affect the development of respiratory distress syndrome (RDS) in premature infants. We aimed to evaluate the relationship between systemic inflammatory indices obtained on the first day of life and the development of RDS in premature infants. Study Design Premature infants with gestational age of ≤32 weeks were included in the study. Six systemic inflammatory indices involving neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ...
Tópico(s): Neuroscience of respiration and sleep
2023 - Thieme Medical Publishers (Germany) | American Journal of Perinatology
Cüneyt Tayman, Nilüfer Okur, Utku Serkant, Ufuk Çakır, Halit Halil, Mehmet Yekta Öncel, Şerife Suna Oğuz, Mehmet Büyüktiryaki,
Objective Endocan, a proteoglycan secreted by endothelial cells, plays a role in the pathogenesis of sepsis. Endocan is an effective diagnostic and prognostic biomarker of sepsis in adult patients. We evaluate the utility of endocan as a new biomarker in the recognition of late-onset neonatal sepsis (LOS) in preterm infants. Methods This study included preterm infants at gestational age ≤ 32 weeks diagnosed with LOS. Sepsis was diagnosed in the presence of three or more clinical findings plus significant ...
Tópico(s): Sepsis Diagnosis and Treatment
2018 - Thieme Medical Publishers (Germany) | Journal of Pediatric Infectious Diseases