Giles Smith, Andrew Robson, David T. Staples, Christina Hardyment, Alexi Mostrous, Nick Wadhams, Dr James Rogers, Robert Thornton, David Brown, Martin Gilbert, Gary Duncan, Simon Barnes, Jane MacQuitty, Robin Pagnamenta Energy and Environment Editor, Peter Lansley, Demi Moore, Sandra Aamodt, Simon Hills, Robert Lindsay, Peter Kinsley, Jane Knight, Sarah Urwin Jones, Fred Schneider, Michael Evans Defence Editor, Emma Cook, Arthur McCann, Philip Howard, Janet Airlie, Tony Turnbull, Alex Wade, Christine Seib, David Chater, Kate Wighton, Rachel Campbell-Johnston, James Marsh, …, Clive Davis, Richard Hobson One-Day Cricket Correspondent, Gabrielle Starkey, Patrick Kidd, Brian, Graham Stewart, Lauren Thompson, David Charter Europe Correspondent, Amanda Lynch, Jane Taylor-Hayhurst, Wendy Ide, James Hider, Jeremy Whittle, Carl Holton, Peter Hobbs, Polly Beard, Bo Lundberg, John Bungey, Bess Twiston-Davies, Andrew Norfolk, Robin Pagnamenta, Rosie Millard, Giles Coren, David Thompson, Sathnam Sanghera, Dr Copperfield, Sean O'Neill Crime Editor, Ben Webster Transport Correspondent, John Arlidge, Valerie Elliott Countryside Editor, Nancy Durrant, Vinny Lee, Donald Hutera, Siobhan Kennedy, Francis Elliott, Jack Malvern, Dominic Walsh, Steve Bird, Rachel Holmes, Peter Straus, Anne Enright, Debra Craine, Gary Jacob, Tom Charity, Victoria Segal, Allan Simmons, Andrea Barrett, Daniel Finkelstein, Justin Gest, Dalya Alberge Arts Correspondent, Peter Ackroyd, Phoebe Greenwood, Jo Morris, Nicholas Blanford, Helen Monks, Doug Johnstone, Pat Shepherd, Charles Wilkinson, Sophie Harris, Rhys Blakely, Andrew Ellson Personal Finance Editor, Sid Smith, David Hands, Ron Lewis, Barbara Kingsolver, Adam Sherwin Media Correspondent, Rev Ralph Barber, Helen Rumbelow, Ben MacHell, David Stevenson, Lucy Sweeney, Tim Teeman, Lilly Peel, Derwent May, Lisa Jardine, Kate Muir, Carole Matthews, Owen Vaughan, Aggie MacKenzie, Russell Kempson, David Muir, Tom Whitwell, Ed Potton, Suzy Jagger, Gary Duncan Economics Editor, Oliver Kay, Claire Bowman, Stephen Anderton, Mark Atherton, Lisa Armstrong, Mark Henderson Science Editor, Michael Theodoulou, Rick Broadbent, John Westerby, George Brock, Tom Baldwin, John Lord, Iain Banks, Jane Wheatley, Sam Coates, Edward Jones, Sally Baker, Samuel, Neel Mukherjee, David Baddiel, Ann Treneman, Douglas Rankine, Pete Paphides, Annie, Rob Wright, Conrad Bell, Mitch Jenkins, Christina Koning, Neil Harman Tennis Correspondent, Peter Smythe, Raymond Keene, Luke Leitch, Adam Sage, Sean O'Neill Crime and Security Editor, Suzi Godson, Matthew Pryor, Jack Aspinall, Kate Saunders, Matt Dickinson, Matt Hughes, Rebecca O'Connor, C. J. Sansom, Gordon Ramsay, Helen Baker, Gill Morgan, Rhubarb Rhapsody, Roger Phillips, Rick Jones, Chris Campling, Adam Fresco Crime Correspondent, Marissa-Catherine Carrarini, Patrick Hosking, Sam Wang, Shane Warne, Rebecca O'connor, Ross Leckie, Erica Wagner, John Betts, Roger Boyes, Karen Sullivan, Marcel Berlins, Kenneth Denby, James Charles, Nick Hasell, Thomasina Miers, Margaret Reynolds, Kevin Maher, Rev Dr Anthony J. Carr, Julian Muscat, Paul Simons, Mike Mulvihill, Nicholas Clee, Steve Jelbert, Nigel Kendall, Nick Szczepanik, Joanna Pitman, Richard Ehrlich, Robert Crampton, Steve Hawkes, Sandy Pratt, Matthew Horne, Graham Chase, Kathryn Marsden, Harriet Addison, Jonathan Powell, Dominic Maxwell, Prue White, Matthew Parris, Andrea Needham, Mark Bridge, Virginia Blackburn, Brian Simpson MEP, Keiran Proffer, Mark Hodkinson, George Caulkin, Amanda Craig, Tim Wapshott, Miles Franklin, Caitlin Moran, Sheila Keating, Neil Fisher, Iain Finlayson, Ben MacIntyre, Andrew Ellson, James S. Maude, David Kottler, Ben Webster, David Hutcheon, Rajeev Syal, John Naish, Bojan Pancevski, James Mawdsley, Catherine Philp, Mark Henderson, Chris Ayres, James Smith, David Rooney, Professor Mike Holcombe, James Jackson, Nigel Hawkes Health Editor, Anna Shepard, Benedict Nightingale, Helen Walsh, Louise Cohen, Jane Smith, Rick Broadbent Athletics Correspondent, Dr Thomas Stuttaford, Stephen Dalton, Leo Lewis, Bill Edgar, Richard Morrison, Tom Chesshyre, James Christopher, Ian G. Townsend, Alice Miles, Robert Cole Personal Investor, Alan Lee Racing Correspondent, Katie Smith, Alan Jackson, Matt Roberts, Will Hide, Jan Raath, Philip Franklin, David Robertson, Lucy Freeman, David Garrett, Robin Rhoderick-Jones, Christopher Irvine,
... had warned BA that 'Big Bang' move would c Terminal 5 Staff 'not fully trained on new baggage ...
2008 - Gale Group | TDA
F. A. Anderer, H. D. Schlumberger, H. Frank,
... group have been prepared, and antisera specific for C-terminal amino acids were obtained from immunized rabbits. There ... a new serological screening technique to detect free C-terminal groups in virus coat proteins. When equivalence of ... is established, differences in the serological reactivity of C-terminal groups to combine with C-terminal group-specific antibodies can be demonstrated. The reactivity of C-terminal threonine in nitrous acid mutant Ni 1927 is less than half and the reactivity of C-terminal alanine in carboxypeptidase-treated tobacco mosaic virus vulgare ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1967 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Yi Xing, Till Böcking, Matthias Wolf, Nikolaus Grigorieff, Tomas Kirchhausen, Stephen C. Harrison,
... to stages of opening and closing of its C-terminal, substrate-binding domain. The latter has a groove ... multi-domain protein that includes, in addition to C-terminal clathrin-binding and J-domain regions, a region ... 2006; Massol et al, 2006). In vitro, a C-terminal fragment (residues 547–910), which includes the clathrin- ... Also required for uncoating in vitro is the C-terminal segment of the heavy chain (Rapoport et al, ... for recruiting Hsc70 to the vicinity of the C-terminal peptide, its presumptive local substrate. An additional consequence ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2009 - Springer Nature | The EMBO Journal
Mads S. Toustrup-Jensen, Rikke Holm, Anja P. Einholm, Vivien R. Schack, Jens Preben Morth, Poul Nissen, Jens Peter Andersen, Bente Vilsen,
... arginine-π stacking interaction between Arg935 and the C-terminal tyrosines. Lys768 may interact preferentially with the C ... arginine-π stacking interaction between Arg935 and the C-terminal tyrosines. Lys768 may interact preferentially with the C ... helices βM, αM7, and αM10, and the two C-terminal tyrosine residues are accommodated in a binding pocket ... C terminus by deletion of the five most C-terminal residues KETYY, which reduced the Na+ affinity of ... however, not clear, whether the position of the C-terminal carboxylate group, the interaction of the side chains, ...
Tópico(s): Plant Stress Responses and Tolerance
2009 - Elsevier BV | Journal of Biological Chemistry
Andreas Büsch, María‐Eugenia Guazzaroni, Jesús Lacal, Juan L. Ramos, Tino Krell,
... Calorimetric studies support that TodT binds to the C-terminal kinase module with a KD of ∼200 nm ... Calorimetric studies support that TodT binds to the C-terminal kinase module with a KD of ∼200 nm ... N-terminal module, the receiver domain and the C-terminal module of the TodS protein, respectively, and the ... phosphotransfer in TodS. TodT Transphosphorylation Occurs from the C-terminal Kinase Domain of TodS—Because TodS contains two ... these data are consistent with phosphotransfer from the C-terminal kinase domain toward TodT. Analysis of Site-directed ...
Tópico(s): Protist diversity and phylogeny
2009 - Elsevier BV | Journal of Biological Chemistry
Masako Hozoji, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda,
... contains disulfide bond(s) between its N- and C-terminal halves, but it remains unclear whether disulfide bond ... contains disulfide bond(s) between its N- and C-terminal halves, but it remains unclear whether disulfide bond ... trypsin, ABCA1 is cleaved at site A, just C-terminal to TM6, and at site B, just N- ... ABCA1. These results suggest that the N- and C-terminal halves of ABCA1 are connected by disulfide bond( ... contains disulfide bond(s) between the N- and C-terminal halves, but it is unclear whether disulfide bond ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2009 - Elsevier BV | Journal of Biological Chemistry
Regina Goetz, Katarzyna Dover, Fernanda Laezza, Nataly Shtraizent, Xiao Huang, Dafna Tchetchik, Anna V. Eliseenkova, Chong Xu, Thomas A. Neubert, David M. Ornitz, Mitchell Goldfarb, Moosa Mohammadi,
... factor homologous factors (FHFs) bind to the intracellular C-terminal region of the Nav α subunit to modulate ... factor homologous factors (FHFs) bind to the intracellular C-terminal region of the Nav α subunit to modulate ... interaction between the DIII-DIV loop and the C-terminal domain of the α subunit stabilizes the inactivated ... fluorescent protein. The functional importance of the cytoplasmic C-terminal domain in Nav physiology is evidenced by the ... 1999Crossref PubMed Scopus (286) Google Scholar). The channel C-terminal domain has been shown to contain binding sites ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2009 - Elsevier BV | Journal of Biological Chemistry
Jindong Xu, Claudia Litterst, Anastasios Georgakopoulos, Ioannis Zaganas, Nikolaos K. Robakis,
... receptor presenilin metalloproteinase familial Alzheimer disease EphB2 receptor C-terminal fragment lactacystin Western blot immunoprecipitation immunoprecipitates immunoprecipitated wild ... receptor presenilin metalloproteinase familial Alzheimer disease EphB2 receptor C-terminal fragment lactacystin Western blot immunoprecipitation immunoprecipitates immunoprecipitated wild ... to the extracellular medium. The remaining membrane-bound C-terminal fragment, termed EphB2/CTF1, is further processed by ... Biotechnology. Magnesium/ATP mixture and recombinant active EphB2R C-terminal kinase were acquired from Upstate Biotechnology (catalog number ...
Tópico(s): Biochemical effects in animals
2009 - Elsevier BV | Journal of Biological Chemistry
S. Rajagopalan, Antonina Andreeva, Daniel P. Teufel, Stefan M.V. Freund, Alan R. Fersht,
... terminal transactivation domain (TAD) of p53 and the C-terminal DNA-binding domain of positive cofactor 4 (PC4CTD). ... terminal transactivation domain (TAD) of p53 and the C-terminal DNA-binding domain of positive cofactor 4 (PC4CTD). ... DNA-binding domain, a tetramerization domain, and a C-terminal regulatory domain (CTD) (2Joerger A.C. Fersht A. ... 60) Google Scholar). transactivation domain single-stranded DNA C-terminal regulatory domain isothermal titration calorimetry glutathione S-transferase ... mtSSB)-binding protein. transactivation domain single-stranded DNA C-terminal regulatory domain isothermal titration calorimetry glutathione S-transferase ...
Tópico(s): RNA Research and Splicing
2009 - Elsevier BV | Journal of Biological Chemistry
... activation loop, the juxtamembrane region, and the region C-terminal to the kinase domain. Because of the divergent ... the tyrosine autophosphorylation sites reside in its extensive C-terminal tail, which would presumably not require the same ... and proceeds to phosphorylate tyrosine residues in the C-terminal tail of the receptor (whether in cis or ... now readily recognized asymmetric kinase dimer, with the C-terminal lobe of the activator kinase abutting the N- ... of the receiver kinase, which wraps around the C-terminal lobe of the activator kinase (Figure 1). Mutagenesis ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2009 - Cell Press | Cell
Claudia A. Bertuccio, Hannah C. Chapin, Yiqiang Cai, Kavita Mistry, Véronique Chauvet, Stefan Somlo, Michael J. Caplan,
... PC-2). PC-1 cleavage releases its cytoplasmic C-terminal tail (CTT), which enters the nucleus. To determine ... activity and in CTT expression, indicating that the C-terminal tail of PC-1 is cleaved and enters ... these treatments. Using a series of PC-2 C-terminal truncated mutations, we identified a portion of the ... regulated by sequences contained within the PC-2 C-terminal tail, suggesting a mechanism through which PC-1 ... PC-2). PC-1 cleavage releases its cytoplasmic C-terminal tail (CTT), which enters the nucleus. To determine ...
Tópico(s): Genetic Syndromes and Imprinting
2009 - Elsevier BV | Journal of Biological Chemistry
Nelli Mnatsakanyan, Jonathon A. Hook, Leah Quisenberry, Joachim Weber,
... portion, with the portions of the N- and C-terminal helices that reach into the α3β3 cylinder removed, ... vary in the folding and positioning of the C-terminal domain. The x-ray structure of the mitochondrial ... Google Scholar) shows the two helices of the C-terminal domain folded back on each other like a ... conformation the angle between both helices of the C-terminal domain of ϵ is ∼90°, it has been ... subunit constructs where the globular domain and the C-terminal helix were eliminated, consisting of just the N- ...
Tópico(s): Biochemical and Molecular Research
2009 - Elsevier BV | Journal of Biological Chemistry
Kenji Satoo, Nobuo N. Noda, Hiroyuki Kumeta, Yūko Fujioka, Noboru Mizushima, Yoshinori Ohsumi, Fuyuhiko Inagaki,
... Atg8 system, nascent Atg8 is cleaved at its C-terminal arginine residue by Atg4, a cysteine protease (Kirisako et al, 2000), and the exposed C-terminal glycine is conjugated to phosphatidylethanolamine (PE) by Atg7, ... Similar to the Atg8 system in yeast, the C-terminal peptide of LC3 is cleaved by mammalian Atg4 ... al, 2006), both of which showed that the C-terminal 39 residues (residues 355–393) are highly flexible, ... with high B-factors. Therefore, we used a C-terminal deletion mutant of HsAtg4B(1–354) for crystallization ...
Tópico(s): Polyamine Metabolism and Applications
2009 - Springer Nature | The EMBO Journal
Shin‐ichi Terawaki, Ken Kitano, Tomoyuki Mori, Yan Zhai, Yoshiki Higuchi, Norimichi Itoh, Takashi Watanabe, Kozo Kaibuchi, Toshio Hakoshima,
... 1 (PDZ) domain, a DH domain and the C-terminal PH (PHc) domain are indicated. The PH–CC– ... comparison with other canonical PH domains, whereas the C-terminal domain boundary was not determined uniquely using sequences. Therefore, we prepared protein molecules that possessed different C-terminal ends for the crystallization. We first succeeded in ... long α-helices (α2 and α3) and a C-terminal Ex subdomain (residues 707–741) forming a small ... β-sandwich capped at one end by a C-terminal α-helix (Figure 2C). At the β1–β2 ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2009 - Springer Nature | The EMBO Journal
Harri Lempiäinen, Thanos D. Halazonetis,
... domain (KD), whose activity is regulated by two C-terminal regions, referred to as PIKK-regulatory domain (PRD) and FRAP-ATM-TRRAP-C-terminal (FATC), respectively. Here, we review functional and structural ... the PIKK-regulatory domain (PRD) and the FAT-C-terminal (FATC) domain (Keith and Schreiber, 1995; Bosotti et ... FATC (C) domains of selected PIKKs to the C-terminal α-helices of the PI3K catalytic subunits p110α ... in the helix and Cys2467 in the sequence C-terminal to the helix (Dames et al, 2005). The ... of deleting these residues. The more highly conserved C-terminal half of the PRD (Figure 1B) appears to ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2009 - Springer Nature | The EMBO Journal
Yao‐Wen Wu, Roger S. Goody, Ruben Abagyan, Kirill Alexandrov,
... or a geranylgeranyl moiety to one or more C-terminal cysteines of the target protein. Rab geranylgeranyl transferase ( ... on the enzyme. This sequence, known as the C-terminal interacting motif is shown to play a dual ... or a geranylgeranyl moiety to one or more C-terminal cysteines of the target protein. Rab geranylgeranyl transferase ( ... on the enzyme. This sequence, known as the C-terminal interacting motif is shown to play a dual ... Rab geranylgeranyl transferase; REP, Rab escort protein; CBR, C-terminal binding region; CIM, CBR interacting motif; NBD, nitrobenzoxadiazole; ...
Tópico(s): Peptidase Inhibition and Analysis
2009 - Elsevier BV | Journal of Biological Chemistry
Marcello Clerici, André Mourão, Irina Gutsche, Niels H. Gehring, Matthias W. Hentze, Andreas E. Kulozik, Jan Kadlec, Michael Sattler, S. Cusack,
... report structural studies on the interaction between the C-terminal region of UPF2 and intact UPF1. Crystal structures, ... its helicase domain in a fixed configuration. The C-terminal region of UPF2 is natively unfolded but binds ... SMG1 is stimulated to phosphorylate UPF1 on its C-terminal SQ-motifs (Kashima et al, 2006). Hyperphosphorylated UPF1 ... 115–914) of UPF1 in complex with the C-terminal region of human UPF2 (residues 1105–1198), providing ... UPF1 and UPF2. We show that the free C-terminal region of UPF2 is unstructured but co-folds ...
Tópico(s): RNA modifications and cancer
2009 - Springer Nature | The EMBO Journal
Kumar Chandan Srivastava, Rohit Gupta, J. M. Chaves, O. P. Srivastava,
... I + motif II + connecting peptide [betaB1(149-252)], C-terminal extension [betaB1(1-234)], C-terminal extension plus motif IV [betaB1(1-190)], or C-terminal extension + motif III + motif IV [betaB1(1-148)]. ... crystallin became water insoluble on the deletion of C-terminal extension and subsequent deletions of the C-terminal domain (C-terminal extension plus motifs III and IV) while it ... of the N-terminal domain but not the C-terminal domain exhibited relatively greater structural changes in the crystallin. The deletion of the C-terminal domain resulted in a greater exposure and disturbance ...
Tópico(s): Spectroscopy Techniques in Biomedical and Chemical Research
2009 - American Chemical Society | Biochemistry
Mao Koyama, Masafumi Tanaka, Padmaja Dhanasekaran, Sissel Lund‐Katz, Michael C. Phillips, Hiroyuki Saito,
... an N-terminal helix bundle and a separate C-terminal domain. To define the possible intramolecular interaction between the N- and the C-terminal domains, we examined the effects on protein stability and lipid-binding properties of exchanging either the C-terminal domain or helix between human and mouse apoA- ... Chemical denaturation experiments demonstrated that replacement of the C-terminal domain or helical segment in human apoA-I ... the N-terminal helix bundle. Removal of the C-terminal domain or alpha-helix in human apoA-I ...
Tópico(s): Cholesterol and Lipid Metabolism
2009 - American Chemical Society | Biochemistry
Li Kung, Sheng‐ce Tao, Jiang Qian, Michael G. Smith, M Snyder, Heng Zhu,
... the two types of proteome microarray with either C-terminal tagged or N-terminal tagged protein were used ... contain most yeast proteins with either N- or C-terminal tags spotted at high density onto microscope slides, ... respective affinity tags. The proteome chips with the C-terminal protein fusions are ideal for screening type-I ... of proteins anchored to the membranes by a C-terminal signal sequence or transmembrane domain (e.g. cytochrome ... performed in duplicate on both the N- and C-terminal fusion libraries. Figure 1.A schematic representation of ...
Tópico(s): Studies on Chitinases and Chitosanases
2009 - Springer Nature | Molecular Systems Biology
... catalytic lobe that is connected to a larger C-terminal regulatory lobe by a flexible activation loop that ... Y) residue (Y416in human Src), and (vii) a C-terminal tail that also contains a regulatory Y residue ( ... by a phosphorylated tyrosine residue located in the C-terminal tail. In addition, the SH3 domain and SH2- ... presence of an unphosphorylated Y residue within the C-terminal tail of the enzyme [2Brown M.T. Cooper ... may retain the intra-molecular interaction between the C-terminal pY residue and the SH2 domain, because the ...
Tópico(s): Eosinophilic Disorders and Syndromes
2009 - Elsevier BV | Journal of Thrombosis and Haemostasis
Yuya Miyazono, Masahito Hayashi, Peter Karagiannis, Yoshie Harada, Hisashi Tadakuma,
... of both connect position of the heads (N, C-terminal or Mid position) and sub-nanometer changes in ... whereas two identical heads are dimerized through the C-terminal coiled-coil. Kinesin walks processively along the MT ... acid chain (residues 324–336) positioned at the C-terminal part of the head, has been proposed ('Power ... anti-parallel type DNA-kinesin connected at the C-terminal end of the neck linker (position 337; see ... Feature (bias length) Figure 1 K336CLM 337 337(C-terminal) End of C-terminus (full) Figure 2 K349CLM ...
Tópico(s): Microtubule and mitosis dynamics
2009 - Springer Nature | The EMBO Journal
Anita Joubel, Robert J. Chalkley, Katalin F. Medzihradszky, Hubert Hondermarck, Alma L. Burlingame,
... The acetylation sites are located mostly in the C-terminal end of p53 where the tetramerization and regulatory ... specific DNA binding by acetylation of the p53 C-terminal domain.Cell. 1997; 90: 595-606Abstract Full Text ... sites detected were localized at the N- and C-terminal ends of the protein on serines 15, 33, ... presented here are the acetylation sites in the C-terminal region of p53. Acetylation occurred on Lys residues ... specific DNA binding by acetylation of the p53 C-terminal domain.Cell. 1997; 90: 595-606Abstract Full Text ...
Tópico(s): Epigenetics and DNA Methylation
2009 - Elsevier BV | Molecular & Cellular Proteomics
Tianhua Ma, Zhe Wang, Yunqian Guo, Duanqing Pei,
... slower cell cycle, phenocopying Nanog(9W) with the C-terminal pentapeptide (WNAAP) of WR deleted. ES cells carrying ... slower cell cycle, phenocopying Nanog(9W) with the C-terminal pentapeptide (WNAAP) of WR deleted. ES cells carrying ... function remains largely undefined. embryonic stem tryptophan repeat C-terminal domain 2 leukemia-inhibitory factor phosphatidylinositol 3-kinase ... into the N-terminal domain, DNA binding homeodomain, C-terminal domain 1, tryptophan repeat (WR) domain, and C-terminal domain 2 (CD2) (Fig. 1A). We first demonstrated ...
Tópico(s): 3D Printing in Biomedical Research
2009 - Elsevier BV | Journal of Biological Chemistry
Hideki Kusunoki, Takashi Takeuchi, Toshiyuki Kohno,
... six α-helices), (ii) both the N- and C-terminal extended ARID domain and (iii) the N-terminal extended ARID domain. However, the structure of the C-terminal extended ARID domain has not been determined yet. ... to be a good candidate to represent the C-terminal ARID domain. Here we report the first NMR- ... these residues are located in the N- and C-terminal regions of Jmj(615-730) (E) Close-up ... that both the direction and length of the C-terminal α-helix of Jmj-ARID (615-730) are ... the Dri-ARID domain [Fig. 2(D)]. The C-terminal helix of the Dri-ARID domain is located ...
Tópico(s): Genomics and Chromatin Dynamics
2009 - Wiley | Proteins Structure Function and Bioinformatics
Daniel V. Bax, Ursula R. Rodgers, M.M.M. Bilek, Anthony S. Weiss,
... and cell surface glycosaminoglycans are not involved. The C-terminal GRKRK motif of tropoelastin can bind to cells ... and cell surface glycosaminoglycans are not involved. The C-terminal GRKRK motif of tropoelastin can bind to cells ... cell adhesive activity, with higher binding requiring the C-terminal 25 amino acids. This region is of interest, ... Scholar) have shown that synthetic peptides containing the C-terminal 29 amino acids of bovine tropoelastin possess cell ... Scholar). This interaction was also localized to the C-terminal domains of tropoelastin.More recent data has shown ...
Tópico(s): Cell Adhesion Molecules Research
2009 - Elsevier BV | Journal of Biological Chemistry
Koen Bartholomeeusen, Frauke Christ, Jelle Hendrix, Jean‐Christophe Rain, Stéphane Emiliani, Richard Bénarous, Zeger Debyser, Rik Gijsbers, Jan De Rijck,
... as a first cellular interaction partner of the C-terminal end of LEDGF/p75 (21.Bartholomeeusen K. De ... T-cell line). The bait construct comprised the C-terminal domain (aa 341–507) of LEDGF/p75. Cell ... ΔNpogZ was produced by PCR amplification of the C-terminal coding region of pogZ from pEGFP-pogZ with ... region. A bacterial expression plasmid encoding MBP-tagged C-terminal pogK, pK-ΔN, was produced by PCR amplification ... ΔN was produced by PCR amplification of the C-terminal coding region of pogZ from pEGFP-pogZ and ...
Tópico(s): Cytomegalovirus and herpesvirus research
2009 - Elsevier BV | Journal of Biological Chemistry
Martin Hořák, Robert J. Wenthold,
... NR1 constructs, a more complex role of the C-terminal cassettes in the trafficking of NR1 subunits emerged. ... surface. Our observations identify the unique roles of C-terminal cassettes in the trafficking of full-length NR1 ... NR1 constructs, a more complex role of the C-terminal cassettes in the trafficking of NR1 subunits emerged. ... surface. Our observations identify the unique roles of C-terminal cassettes in the trafficking of full-length NR1 ... M1–4), two extracellular regions, and an intracellular C-terminal region. Recent evidence suggests that abnormal surface expression ...
Tópico(s): Receptor Mechanisms and Signaling
2009 - Elsevier BV | Journal of Biological Chemistry
Lucimar T. Ferreira, Lianne B. Dale, Fabíola M. Ribeiro, Andy V. Babwah, Macarena Pampillo, Stephen S. G. Ferguson,
... mouse cortical brain lysates. Purified CAIN and its C-terminal domain specifically interact with glutathione S-transferase fusion ... to the second intracellular loop and the distal C-terminal tail domains of mGluR1. The interaction of CAIN ... HEK 293 cells, but expression of the CAIN C-terminal domain does not alter mGluR5a internalization. In contrast, ... of either full-length CAIN or the CAIN C-terminal domain impairs agonist-stimulated inositol phosphate formation in ... mouse cortical brain lysates. Purified CAIN and its C-terminal domain specifically interact with glutathione S-transferase fusion ...
Tópico(s): Ion channel regulation and function
2009 - Elsevier BV | Journal of Biological Chemistry
Fabrice Michel, Corinne Crucifix, Florence Granger, Sylvia Eiler, Jean‐François Mouscadet, S.V. Korolev, Julia Agapkina, Rustam Ziganshin, Marina Gottikh, Alexis Nazabal, Stéphane Emiliani, Richard Benarous, Dino Moras, Patrick Schultz, Marc Ruff,
... the Tn5 transposase (Haren et al, 1999). The C-terminal domain (residues 213–288) of IN has an ... 2004), or with either the N- or the C-terminal domains (Chen et al, 2000; Wang et al, ... occurs through the CCD of IN and the C-terminal integrase-binding domain (IBD) of LEGDF (Busschots et ... of the protein domains (Supplementary Protocol 4). The C-terminal IN extensions fit into each of the branches ... accommodates the atomic structure of the catalytic and C-terminal IN domains is contoured by red dots. (C) ... of the top branch of the Y domain (C-terminal domain of integrase), which results in a closure ...
Tópico(s): CRISPR and Genetic Engineering
2009 - Springer Nature | The EMBO Journal