Directory of Open Access Journals (DOAJ)
James H. Conover, Nicholas G. Beratis, Elaine J Conod, Eugene Ainbender, Kurt Hirschhorn,
... and two carriers, contained a ciliary dyskinesia factor (CDF) detected by a modified rabbit tracheal bioassay. Positive CDF responses began to be observed in supernates of ... four normal donors did not produce a positive CDF response with or without PHA over a period ... and four CF carrier subjects demonstrated a positive CDF response, while media from similar lymphoid lines derived from normal subjects contained no CDF. Distinction between homozygous and heterozygous lymphoid lines was ... of the homozygous lines to give an earlier CDF response than the heterozygous ones. Addition of rabbit ...
Tópico(s): Macrophage Migration Inhibitory Factor
1973 - Springer Nature | Pediatric Research
ASTM International
Nicholas G. Beratis, James H. Conover, Elaine J Conod, Richard J. Bonforte, Kurt Hirschhorn,
... fibrosis (CF) were investigated for ciliary dyskinesia factor (CDF) by a modified rabbit tracheal bioassay. Fluid was ... feeding, before confluence had been reached. A positive CDF response was demonstrated in the media of all ... culture fluid with human immunoglobulin G (IgG). No CDF response was observed before the addition of IgG. ... CF homozygous fibroblast cultures to elicit a stronger CDF response than the media from heterozygous cultures, no ... cultures derived from normal donors did not demonstrate CDF activity before or after the addition of IgG. ...
Tópico(s): Neonatal Respiratory Health Research
1973 - Springer Nature | Pediatric Research
ASTM International
B. Vialettes, R. Picq, M. du Rostu, B Charbonnel, M. Rodier, J Mirouze, P Vexiau, P Passa, M Pehuet, F. Elgrably, P Vague,
... as those used in the Cyclosporin Diabetes France (CDF) programme in which all five of the centres ... therefore compared retrospectively with those of the placebo (CDF‐placebo) and cyclosporin (CDF‐active) group of the CDF programme. Clinical remission (fasting plasma glucose <7.8 ... 34 %) vs 16 out of 63 (25 %) in CDF‐active and 11 out of 59 (19 %) in CDF‐placebo. Remission was achieved by month 9 in ... 17 %) vs 13 out of 54 (24 %) in CDF‐active and 3 out of 52 (6 %) in CDF‐placebo. By 12 months remission persisted in 3 ... 9 %) vs 11 out of 63 (17 %) in CDF‐active and 0 out of 52 (0 %) in ...
Tópico(s): Diabetes Treatment and Management
1990 - Wiley | Diabetic Medicine
Subimal Ghosh, P. P. Mujumdar,
... which are evaluated with the Cumulative Distribution Functions (CDFs) generated from the downscaled GCM output (for both ... represented as an interval gray number. Furthermore, the CDF generated with one GCM is entirely different from ... of multiple GCMs results in a band of CDFs. Representing this band of CDFs with a single valued weighted mean CDF may be misleading. Such a band of CDFs can only be represented with an envelope that contains all the CDFs generated with a number of GCMs. Imprecise CDF represents such an envelope, which not only contains ...
Tópico(s): Hydrology and Watershed Management Studies
2009 - American Geophysical Union | Journal of Geophysical Research Atmospheres
... s Congregation for the Doctrine of the Faith (CDF). Steven J. Pope has led an exceptional group ... respond to the “significant questions” raised by the CDF, “to take seriously both the concerns of the [CDF] and the theological insight offer by Sobrino to ... is part of a grassroots response to the CDF’s queries.Those of us who became Latin ... the 1980s cringe at any charge by the CDF: Leonardo Boff and Gustavo Gutiérrez, two notable Latin ... challenge is extraordinary. The former head of the CDF during the 1980s is now the current Pope ...
Tópico(s): Religious and Theological Studies
2009 - Duke University Press | Hispanic American Historical Review
National Bureau of Economic Research (NBER)
Ayako Fukunaka, Tomoyuki Suzuki, Yayoi Kurokawa, Tomohiro Yamazaki, Naoko Fujiwara, Kaori Ishihara, Hitoshi Migaki, Katsuzumi Okumura, Seiji Masuda, Yuko Yamaguchi‐Iwai, Masaya Nagao, Taiho Kambe,
The majority of CDF/ZnT zinc transporters form homo-oligomers. However, ZnT5, ZnT6, and their orthologues form hetero-oligomers in the early secretory ... known about homo-oligomerization that occurs in other CDF/ZnT family proteins. Here, we addressed this issue ... transmembrane domains II and V in which many CDF/ZnT proteins have conserved hydrophilic amino acid residues ... they are required for zinc transport in other CDF/ZnT family homo-oligomers. We also found that ... about the mechanism of action through heterodimerization of CDF/ZnT proteins that function in the early secretory ...
Tópico(s): Heavy Metal Exposure and Toxicity
2009 - Elsevier BV | Journal of Biological Chemistry
Diana Davis, Hyun Cheol Roh, Krupa Deshmukh, Janelle J. Bruinsma, Daniel L. Schneider, James Guthrie, J. David Robertson, Kerry Kornfeld,
... and zinc content varied 27-fold. We investigated cdf-2, which encodes a predicted zinc transporter in the cation diffusion facilitator family. cdf-2 mRNA levels were increased by high dietary zinc, suggesting cdf-2 promotes zinc homeostasis. CDF-2 protein was expressed in intestinal cells and localized to cytosolic vesicles. A cdf-2 loss-of-function mutant displayed impaired growth and reduced zinc content, indicating that CDF-2 stores zinc by transport into the lumen of vesicles. The relationships between three cdf genes, cdf-1, cdf-2, and sur-7, ...
Tópico(s): Heavy Metal Exposure and Toxicity
2009 - Oxford University Press | Genetics
Chankyu Park, Jacqueline H. Finger, Jonathan A. Cooper, Susan L. Ackerman,
Abstract Summary: Cerebellar deficient folia ( cdf ) is a recently identified mouse mutation causing ataxia and cerebellar abnormalities including lobulation defects and abnormal placement of a specific subset ... understand the etiology of the cerebellar defects in cdf mutant mice, we examined postnatal development of the cdf/cdf cerebellum. Our results demonstrate that Purkinje cell ectopia ... foliation defects are apparent at birth, suggesting the cdf mutation disrupts the positioning of many, but not ... we observed lamination defects in the hippocampus of cdf mutant mice, although neocortical defects were not seen. ...
Tópico(s): Microtubule and mitosis dynamics
2002 - Wiley | genesis
James T. Colston, Bysani Chandrasekar, Gregory L. Freeman,
... determine whether the exposure of cardiac derived fibroblasts (CDFs) to H2O2 for a brief time would cause ... DRR/National Institutes of Health, Bethesda, MD1985Google Scholar). CDFs were isolated from the hearts of adult male ... cell pellet was resuspended in 20 ml of CDF medium (15 mm HEPES, 16.7 mm NaHCO3, ... with fresh medium three times per week using CDF medium and split 1:3 when confluent. CDF and non-fibroblast contaminants were identified by immunofluorescence ... cultured under conditions identical to those described for CDFs and split 1:3 when confluent. Intracellular calcium ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2002 - Elsevier BV | Journal of Biological Chemistry
Jae-Yong Ryu, James A. Mulholland, Byoung Chu,
... surfaces is a potential source of chlorinated dibenzofuran (CDF). Gas streams containing 8% O(2) and approximately ... 400 degrees C to investigate the potential for CDF formation during particle collection. Experiment duration was sufficient ... chlorination by CuCl(2) and the distribution of CDF products were measured, with effects of temperature, gas ... DF/DD conversion. Total yields of Cl on CDF/CDD products of up to 0.5 mole ... 3), nearly 100% DF adsorption and conversion to CDF was achieved. The degree of CDF chlorination was ...
Tópico(s): Atmospheric chemistry and aerosols
2003 - Elsevier BV | Chemosphere
Maciej J. Zamek‐Gliszczynski, Hao Xiong, Nita Patel, Ryan Z. Turncliff, Gary M. Pollack, Kim L. R. Brouwer,
... of 5 (and 6)-carboxy-2′,7′-dichlorofluorescein (CDF) and its diacetate promoiety (CDFDA) was studied in ... Mrp)2-deficient (TR − ) rats were perfused with CDF in the presence or absence of probenecid. Probenecid decreased the recovery of CDF in bile ∼4-fold in wild-type livers ( ... over 2 h). In livers from TR − rats, CDF was not excreted into bile and probenecid decreased perfusate CDF concentrations in a concentration-dependent manner, in part ... transfected Sf9 cells were used to confirm that CDF is a substrate for Mrp2 and Mrp3; probenecid ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2003 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
John H. Yoder, Huira Chong, Kun‐Liang Guan, Min Han,
... 8/SOC-2, SUR-6/PP2A-B and CDF-1. We describe the functional characterization of sur- ... 2000). Additionally, a C. elegans cation diffusion facilitator (CDF) family member, cdf-1, was identified as a positive regulator of Ras signaling (Bruinsma et al, 2002). Presumably, cdf-1(lf) results in increased cytosolic zinc concentrations, ... Here we characterize the role of a divergent CDF family member, sur-7, as a positive regulator ... allele. SUR-7 cloning and classification as a CDF family member To identify the sur-7 locus, ...
Tópico(s): Selenium in Biological Systems
2003 - Springer Nature | The EMBO Journal
Assia Jaillard, Sylvie Grand, J.F. Le Bas, Marc Hommel,
Cognitive dysfunctioning (CDF) is an important issue in stroke, interfering with recovery and social dysfunctioning. We aimed to investigate the clinical and imaging correlates of CDF in patients with a first-ever subacute ischemic stroke and no dementia.We evaluated CDF 15 days after stroke in a prospective cohort ... score > or =23 using a comprehensive neuropsychological battery. CDF was ranked into 3 categories according to Z ... each test and adjusted for age and education. CDF was analyzed in relation to stroke features. Imaging ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2010 - Karger Publishers | Cerebrovascular Diseases
Duncan R. Campbell, Kaye E. Chapman, Kevin J. Waldron, Stephen Tottey, Sharon L. Kendall, Gabriele Cavallaro, Claudia Andreini, Jason Hinds, Neil G. Stoker, Nigel J. Robinson, Jim Cavet,
... show elevated expression of Rv2025c encoding a deduced CDF-family metal exporter. KmtR-dependent repression of the cdf and kmtR operator-promoters was alleviated by nickel ... containing a region of dyad symmetry from the cdf and kmtR operator-promoters. Incubation of KmtR with ... with Gln generated KmtR variants that repress the cdf and kmtR operator-promoters even in elevated nickel ... show elevated expression of Rv2025c encoding a deduced CDF-family metal exporter. KmtR-dependent repression of the cdf and kmtR operator-promoters was alleviated by nickel ...
Tópico(s): Corrosion Behavior and Inhibition
2007 - Elsevier BV | Journal of Biological Chemistry
Barbara Montanini, Damien Blaudez, Sylvain Jeandroz, Dale Sanders, Michel Chalot,
Abstract Background The Cation Diffusion Facilitator (CDF) family is a ubiquitous family of heavy metal transporters. Much interest in this family has focused on implications for human health and ... of the functional characteristics of some fully characterised CDF transporters, has aimed at identifying molecular determinants of ... and at suggesting metal specificity for newly identified CDF transporters. Results Representative CDF members from all three kingdoms of life (Archaea, ... that can be used to identify new hypothetical CDF members. Phylogenetic reconstruction has classified the majority of ...
Tópico(s): Drug Transport and Resistance Mechanisms
2007 - BioMed Central | BMC Genomics
Jeffery L. Gustin, Michael J. Zanis, David E. Salt,
Members of the cation diffusion facilitator (CDF) family are integral membrane divalent cation transporters that transport metal ions out of the cytoplasm either into the extracellular space or into ... known to be transported by proteins of the CDF family include Zn, Fe, Co, Cd, and Mn. ... eukaryotes, and archaea, and in sequenced plant genomes. CDF families range in size from nine members in ... in Populus trichocarpa. Phylogenetic analysis suggests that the CDF family has expanded within plants, but a definitive ...
Tópico(s): Plant Micronutrient Interactions and Effects
2011 - Springer Science+Business Media | BMC Evolutionary Biology
Mathieu Vrac, P. Drobinski, A. Merlo, Marine Herrmann, Christophe Lavaysse, Laurent Li, Samuel Somot,
... and WRF) and from one statistical downscaling model (CDF-t) are used to evaluate the uncertainty in ... of wind, temperature, and rainfall cumulative distribution functions (CDFs) for eight stations in the French Mediterranean basin ... measure the "distance" between the simulated and observed CDFs. The ability of the three RCMs and CDF-t to simulate the "climate" variability is quantified ... always much better than ERA-40 reanalyses, whereas CDF-t produces accurate results when applied to ERA- ... downscaling approach has been used, consisting in applying CDF-t to the RCM outputs. It shows that ...
Tópico(s): Hydrology and Drought Analysis
2012 - Copernicus Publications | Natural hazards and earth system sciences
The cation diffusion facilitators (CDF) are a ubiquitous family of metal transporters that play important roles in homeostasis of a wide range of divalent metal ... binding sites and their metal selectivity in the CDF family are thus far unknown. By using isothermal ... a highly conserved aspartate in the Escherichia coli CDF transporter YiiP (FieF). A D157A mutation abolished a ... role in metal transport. The cation diffusion facilitators (CDF) are a ubiquitous family of metal transporters that ... binding sites and their metal selectivity in the CDF family are thus far unknown. By using isothermal ...
Tópico(s): Extraction and Separation Processes
2005 - Elsevier BV | Journal of Biological Chemistry
Priyamvada Chandra, Brendan M. Johnson, Peijin Zhang, Gary M. Pollack, Kim L. R. Brouwer,
... substrate, 5- (and 6)-carboxy-2′,7′dichlorofluorescein (CDF) in rat isolated perfused livers (IPLs). In vivo ... Mrp) 3, and Mrp2] governing the disposition of CDF. The basolateral and biliary excretion of CDF was measured in single-pass IPLs from control and treated rats. Modulators increased the percentage of CDF eliminated into perfusate of IPLs from treated rats (∼20-35%) compared with controls (∼10%); CDF biliary excretion was decreased in the treated groups. ... increases in the first-order rate constant governing CDF excretion from the hepatocytes into perfusate ( k perfusate ) ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2005 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
... is a member of the cation diffusion facilitator (CDF) family that mediates efflux of zinc across the ... is a member of the cation diffusion facilitator (CDF) family that mediates efflux of zinc across the ... 14331Crossref PubMed Scopus (344) Google Scholar) and the CDF 1The abbreviations used are: CDF, cation diffusion facilitator; TEA, tetraethylammonium; DDM, n-dodecyl- ... 183: 4664-4667Crossref PubMed Scopus (125) Google Scholar). CDF is a ubiquitous family of metal transporters found ... Scopus (295) Google Scholar). Sequence analysis suggests that CDF proteins contain a hydrophobic N-terminal domain followed ...
Tópico(s): Aluminum toxicity and tolerance in plants and animals
2004 - Elsevier BV | Journal of Biological Chemistry
Tanawat Jirakulaporn, Anthony J. Muslin,
... it was demonstrated that the cation diffusion facilitator (CDF) proteins are involved in Ras-ERK signaling by ... Ras. In the current work, we demonstrate that CDF proteins may function downstream of Ras, but upstream ... We also show that the C. elegans protein CDF-1 and its mammalian homologue ZnT-1 bind ... ZnT-1. We propose a model in which CDF protein binding facilitates Raf-1 activation. The Ras- ... it was demonstrated that the cation diffusion facilitator (CDF) proteins are involved in Ras-ERK signaling by ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2004 - Elsevier BV | Journal of Biological Chemistry
... is a member of the cation diffusion facilitator (CDF) 1The abbreviations used are: CDF, cation diffusion facilitator; SEC, size-exclusion chromatography; EDC, ... Google Scholar). Analysis of genome sequences shows that CDFs represent a ubiquitous protein family, encompassing more than ... Despite large variability in the hydrophilic region, all CDF family members identified so far, prokaryotic or eukaryotic, ... 346: 362-365Crossref PubMed Scopus (957) Google Scholar). CDFs operate with an antiport mechanism that utilizes the ...
Tópico(s): Electrochemical Analysis and Applications
2004 - Elsevier BV | Journal of Biological Chemistry
Chankyu Park, Chantal M. Longo, Susan L. Ackerman,
Cerebellar deficient folia (cdf) is a recessive mouse mutation causing ataxia and cerebellar cytoarchitectural abnormalities, including hypoplasia, foliation defects, and Purkinje cell ectopia. To identify the cdf gene, we have generated a high-resolution genetic ... 0.55 cM (95% CI) region encompassing the cdf gene using 1997 F2 mice generated from a (C3H/HeSnJ-cdf/cdf × CAST/Ei)F1 intercross. Linkage analysis showed that the cdf gene cosegregates with D6Mit208, D6Mit359, and D6Mit225. A ... BACs, and three P1s was constructed across the cdf nonrecombinant region. Based on genetic and physical maps, ...
Tópico(s): Genomic variations and chromosomal abnormalities
2000 - Elsevier BV | Genomics
Hui Liu, Joong-Wook Park, Max M. Häggblom,
... 3,4-tetrachlorodibenzofuran (1,2,3,4-tetra-CDF), octachlorodibenzofuran (octa-CDF) and 1,2,3,4-tetrachlorodibenzo-p-dioxin ( ... 4-tetra-CDD). 1,2,3,4-tetra-CDF was dechlorinated via 1,2,3-, 2,3, ... and 1,3,4/1,2,4-tri-CDFs to 1,3-, 2,3-, and 2,4-di-CDFs and finally to 4-mono-CDF. The dechlorination rate of 1,2,3,4-tetra-CDF was generally slower than that of 1,2, ... as a co-substrate. Dechlorination of spiked octa-CDF was observed with the production of hepta-, hexa-, penta- and tetra-CDFs over 6 months. Two major phylotypes of the ...
Tópico(s): Groundwater flow and contamination studies
2013 - Elsevier BV | Environmental Pollution