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Artigo Acesso aberto Revisado por pares

Emily Rosenich, Lisa Bransby, Nawaf Yassi, Jürgen Fripp, Simon M. Laws, Ralph N. Martins, Christopher Fowler, Stephanie R. Rainey‐Smith, Christopher C. Rowe, Colin L. Masters, Paul Maruff, Yen Ying Lim,

... Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score with hippocampal volume (HV) loss and ... were included in this study. We computed the CAIDE risk score (age, sex, APOE ε4 status, education, ... index [BMI], hypercholesterolemia, physical inactivity) and a modifiable CAIDE risk score (CAIDE-MR; education, hypertension, BMI, hypercholesterolemia, physical inactivity) for ... 25. Linear mixed models assessed interactions between each CAIDE score, Aβ group, and time on HV loss ... APOE ε4 were included as separate predictors in CAIDE-MR models to assess differential associations. Exploratory analyses ...

Tópico(s): Neurological Disease Mechanisms and Treatments

2022 - Lippincott Williams & Wilkins | Neurology

Artigo Acesso aberto Revisado por pares

Audrey Low, Maria A Prats‐Sedano, James D. Stefaniak, Elizabeth McKiernan, Stephen F. Carter, Maria-Eleni Douvani, Elijah Mak, Li Su, Olivia Stupart, Graciela Muniz, Karen Ritchie, Craig Ritchie, Hugh S. Markus, John T. O’Brien,

... whether the Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score was associated with markers of cerebral ... protein (CRP) and fibrinogen. Results At baseline, higher CAIDE scores were associated with all markers of SVD and inflammation. Longitudinally, CAIDE scores predicted greater total (p<0.001), periventricular ( ... increased CRP (p=0.017). Assessment of individual CAIDE components suggested that markers were driven by different ... microbleeds: hypertension/obesity). Interaction analyses demonstrated that higher CAIDE scores amplified the effect of age on SVD, ...

Tópico(s): Dementia and Cognitive Impairment Research

2022 - BMJ | Journal of Neurology Neurosurgery & Psychiatry

Artigo Acesso aberto Revisado por pares

Ruth Stephen, Yawu Liu, Tiia Ngandu, Juha O. Rinne, Nina Kemppainen, Riitta Parkkola, Tiina Laatikainen, Teemu Paajanen, Tuomo Hänninen, Timo Strandberg, Riitta Antikaínen, Jaakko Tuomilehto, Sirkka Keinänen Kiukaanniemi, Ritva Vanninen, Seppo Helisalmi, Esko Levälahti, Miia Kivipelto, Hilkka Soininen, Alina Solomon,

CAIDE Dementia Risk Score is the first validated tool for estimating dementia risk based on a midlife ... profile.This observational study investigated longitudinal associations of CAIDE Dementia Risk Score with brain MRI, amyloid burden ... FINGER participants were at-risk elderly without dementia. CAIDE Risk Score was calculated using data from previous ... white matter lesions (WML), and amyloid accumulation.Higher CAIDE Dementia Risk Score was related to more pronounced ... 20 for memory, all p < 0.001). Higher CAIDE Dementia Risk Score including APOE genotype was additionally ...

Tópico(s): Neurological Disease Mechanisms and Treatments

2017 - IOS Press | Journal of Alzheimer s Disease

Jornais Acesso aberto

E. M. Wynne, James Laver, Mariam Iselin, J. G. N., Doreen Wallace, James Agate, Desmond MacCarthy, B. M., W. W. Hadley, L. C. Bagg Captain (ret), Walter G. Bell, John Brophy, Astley Terry, J. D. McCormick, J. Wentworth Day, Ormonde Butler, J. Henderson Stewart, Charles Vivian, La Bandera, M. Lebrun, A. T. Johnson, Mr. Punshon's Riddle, L. A. Pavey, G. W. B., W. P. Koe Capt. R. N. (ret), J. B. Firth, Frank Rutter, William R. Power, D. R. Gent, Mr. Kirkwood's Story, C. L., Evelyn G. M. Carmichael Of Carmichael, H. F., Sir Edgar Britten, Sir Vivian Henderson, Gerald Heard, Ernest Newman, Mr. Herbert Morrison's, Ralph Straus, Frank Wilson, S. A. Boyd, J. N. D. La Touche, Hugh J. Goolden, G. A. Tomlin, E. V. Lucas, De Beers, Sir W. W. Butler's, H. S. Shield, Sir F. Goodenough's, Muriel Beckwith, Sydney W. Carroll, W. H. D. Rouse, Cecil Collins Major (ret), Mr. Duff Cooper's, Mary Butts, Edward Shanks, E. Bonner, R. Ellis Roberts, H. E. Symons, G. T. G., R. J. Barrett Financial Editor, S. W. P., Lloyd's, J. Rowland Hopwood, Henry Longhurst, T. G. Martin, Reviewed Milward Kennedy, Hubert Fitchew, Yarborough, Israel Hoffman, A. MacDermott, J. M. Bulloch, A. M. S., H. E. Wortham, Atticus, Kaffirs, Sir S. Hoare's, George W. Bishop, Mr. Duff Cooper, John Betjeman, D. M. Lindsay, R. L. B., Gwendolen MacMillan, Mr. A. M. Hind's Monumental,

... for Rheumatism Dr. Gaertner relates his experience Ossi Caide Ltd. Multiple Display Advertising Items Hotels, Cruises, Tours ...

1935 - Gale Group | Sunday Times HA GDA

Artigo Revisado por pares

M. Ecay, Ainara Estanga, Mikel Tainta, Andrea Izagirre, Maite García-Sebastián, Jorge Villanúa, Montserrat Clerigué, Ane Iriondo, Iratxe Urreta, Arantzazu Arrospide, Carmen Díaz Mardomingo, Miia Kivipelto, Pablo Martínez‐Lage,

... with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this ... LR; n = 293) for dementia according to a CAIDE score cutoff of 9. Cognitive composites were compared ... phosphorylated tau (p-tau) in the association between CAIDE score and cognition.HR participants obtained lower scores ... 0.001) composites. EF composite was associated with CAIDE score × p-tau (p = 0.001), CAIDE score × t-tau (p = 0.001), and WMH ( ... Healthy participants at increased dementia risk based on CAIDE scores show lower performance in EF and VPC. ...

Tópico(s): Alcoholism and Thiamine Deficiency

2018 - Lippincott Williams & Wilkins | Neurology

Artigo Acesso aberto Revisado por pares

Aurore Fayossé, Dinh-Phong Nguyen, Aline Dugravot, Julien Dumurgier, Ádám G. Tabák, Mika Kivimäki, Séverine Sabia, Archana Singh‐Manoux,

... Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS) and FINDRISC ... used to model associations of age at baseline, CAIDE, FRS, and FINDRISC risk scores with incident dementia. ... Among the risk scores, the predictive performance of CAIDE (C-statistic = 0.714; 95% CI 0.690– ... remained for FRS and FINDRISC, but not for CAIDE. Only FRS at age 55 was associated with ...

Tópico(s): Frailty in Older Adults

2020 - BioMed Central | BMC Medicine

Artigo Acesso aberto Revisado por pares

Ruth Stephen, Tiia Ngandu, Yawu Liu, Markku Peltonen, Riitta Antikaínen, Nina Kemppainen, Tiina Laatikainen, Jyrki Lötjönen, Juha O. Rinne, Timo Strandberg, Jaakko Tuomilehto, Ritva Vanninen, Hilkka Soininen, Miia Kivipelto, Alina Solomon,

Abstract The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously ... biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied ... intervention. This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers (brain magnetic ... scans were available for 39 participants. Reduction in CAIDE score (indicating lower dementia risk) during the intervention ...

Tópico(s): Blood Pressure and Hypertension Studies

2021 - Oxford University Press | The Journals of Gerontology Series A

Artigo Acesso aberto Revisado por pares

Xulin Liu, Maria‐Eleni Dounavi, Karen Ritchie, Katie Wells, Craig Ritchie, Li Su, Graciela Muñiz‐Terrera, John T. O’Brien,

... symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be associated with ... longitudinally between subjects with high and low baseline CAIDE score (CAIDE score was dichotomized at cohort-median). A GM ... total intracranial volume. Results Compared to subjects with CAIDE score ≤ 6 (low risk), subjects with CAIDE score > 6 (high risk) showed lower GM volume ... regions in healthy middle-aged subjects with high CAIDE scores.

Tópico(s): Cerebrovascular and Carotid Artery Diseases

2021 - Springer Science+Business Media | Journal of Neurology

Artigo Acesso aberto Revisado por pares

Shireen Sindi, Elisabeth Calov, J. G. Fokkens, Tiia Ngandu, Hilkka Soininen, Jaakko Tuomilehto, Miia Kivipelto,

Abstract Background The CAIDE (Cardiovascular Risk Factors, Aging, and Incidence of Dementia) Dementia Risk Score is a validated tool to predict late‐life ... render this prediction tool widely accessible. Methods The CAIDE Risk Score (mobile application) App was developed based on the CAIDE Dementia Risk Score, involving information on age, educational ... hypertension, hypercholesterolemia, obesity, and physical inactivity. Results The CAIDE Risk Score App is an evidence‐based practical ... preventive measures and monitor risk reduction. Conclusions The CAIDE Risk Score App is the first to predict ...

Tópico(s): Nutritional Studies and Diet

2015 - Elsevier BV | Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Artigo Acesso aberto Revisado por pares

Babak Hooshmand, Tuomo Polvikoski, Miia Kivipelto, Maarit Tanskanen, Liisa Myllykangas, Mika J. Mäkelä, Minna Oinas, Anders Paetau, Alina Solomon,

CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its longitudinal ... are not known.To explore the relationship between CAIDE Dementia Risk Score at baseline and neuritic plaques, ... microscopic infarcts, CAA and α-synuclein pathologies. The CAIDE Dementia Risk Score was calculated based on scores ... APOEε4 carrier status (range 0-18 points).A CAIDE Dementia Risk Score above 11 points was associated ... a population of elderly aged ≥85 years, higher CAIDE Dementia Risk Score was associated with increased risk ...

Tópico(s): Neurological Disease Mechanisms and Treatments

2018 - Wiley | Journal of Internal Medicine

Artigo Acesso aberto Revisado por pares

Tatjana Rundek, Hannah Gardener, A. Saporta, David Loewenstein, Ranjan Duara, Clinton B. Wright, Chuanhui Dong, Bonnie Levin, Mitchell S.V. Elkind, Ralph L. Sacco,

... Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score, a validated tool to estimate ... score (GVRS), created to predict vascular events.The CAIDE and GVRS scores were calculated based on baseline ... speed, and averaged to calculate global cognition.The CAIDE score was associated with worse global cognition at ... a stronger predictor of cognitive decline than the CAIDE in a multi-ethnic urban cohort. The inclusion ... smoking in the GVRS, which are absent in CAIDE, likely explains the better performance of the GVRS.

Tópico(s): Cerebrovascular and Carotid Artery Diseases

2019 - IOS Press | Journal of Alzheimer s Disease

Artigo Acesso aberto Revisado por pares

Lieza G. Exalto, Charles P. Quesenberry, Deborah E. Barnes, Miia Kivipelto, Geert Jan Biessels, Rachel A. Whitmer,

... score cardiovascular risk factors , aging and dementia study (CAIDE) constituting age, education, hypertension, obesity, and hyperlipidemia in ... population. Our second aim was to improve the CAIDE risk score by additional midlife risk factors. Methods ... of follow‐up was 36.1 years. The CAIDE risk score replicated well with a C statistic of 0.75, quite similar to the original CAIDE C statistic of 0.78. The CAIDE score also predicted well within different race strata. ...

Tópico(s): Nutrition and Health in Aging

2013 - Wiley | Alzheimer s & Dementia

Revisão Acesso aberto Revisado por pares

Stephanie L. Harrison, Anton J.M. de Craen, Ngaire Kerse, Ruth Teh, Antoneta Granic, Karen Davies, Keith Wesnes, Wendy P. J. den Elzen, Jacobijn Gussekloo, Thomas B. L. Kirkwood, Louise Robinson, Carol Jagger, Mario Siervo, Blossom C. M. Stephan,

... Cardiovascular Risk Factors, Aging, and Incidence of Dementia ( CAIDE ) risk score, and oxi‐inflammatory load (cumulative risk ... LACS NZ Study) participants (n = 396). Measurements FSRP , CAIDE risk score, oxi‐inflammatory load, FSRP incorporating oxi‐inflammatory load, and CAIDE risk score incorporating oxi‐inflammatory load. Oxi‐inflammatory ... 95% confidence interval ( CI ) = 1.08–1.98), CAIDE ( HR = 1.53, 95% CI = 1.09–2. ... 95% CI = 1.17–2.33) and the CAIDE model ( HR = 1.93, 95% CI = 1.39– ...

Tópico(s): GDF15 and Related Biomarkers

2016 - Wiley | Journal of the American Geriatrics Society

Artigo Acesso aberto Revisado por pares

Daniela Enache, Alina Solomon, Lena Cavallin, Ingemar Kåreholt, Milica G. Kramberger, Dag Aarsland, Miia Kivipelto, Maria Eriksdotter, Bengt Winblad, Vesna Jelić,

... between Cardiovascular Risk Factors, Aging and Dementia Study (CAIDE) Dementia Risk Score and dementia-related cerebrospinal fluid ... for white matter changes (WMC) were performed. Higher CAIDE Dementia Risk Score (version without APOE) was significantly ... WMC, and global cortical atrophy-frontal subscale. Higher CAIDE Dementia Risk Score (version with APOE) was associated with reduced Aβ, more severe MTA, and WMC. CAIDE Dementia Risk Score version with APOE seemed to ...

Tópico(s): Neurological Disease Mechanisms and Treatments

2016 - Elsevier BV | Neurobiology of Aging

Artigo Acesso aberto Revisado por pares

E. Julia Chosy, Steven D. Edland, Noele Gross, Marnie Meyer, Catherine Y. Liu, Lenore J. Launer, Lon R. White,

<b><i>Introduction:</i></b> The CAIDE (Cardiovascular Risk Factors, Aging, and Incidence of Dementia) dementia risk score is based on demographic, genetic, and modifiable risk factors in midlife ... b> To test the predictive capacity of the CAIDE dementia risk score among a cohort of Japanese- ... i>Results:</i></b> In this cohort, the CAIDE dementia risk score demonstrates significant association with later- ... 50). <b><i>Conclusion:</i></b> While the CAIDE dementia risk score at midlife is associated with ...

Tópico(s): Blood Pressure and Hypertension Studies

2019 - Karger Publishers | Dementia and Geriatric Cognitive Disorders

Artigo Acesso aberto Revisado por pares

Md Hamidul Huque, Scherazad Kootar, Ranmalee Eramudugolla, S. Duke Han, Michelle C. Carlson, Oscar L. López, David A. Bennett, Ruth Peters, Kaarin J. Anstey,

... ANU-ADRI), Cardiovascular Risk Factors, Aging, and Dementia (CAIDE), and Lifestyle for Brain Health (LIBRA) dementia risk ... To evaluate the performance of CogDrisk, ANU-ADRI, CAIDE, LIBRA, and modified LIBRA (LIBRA with age and ... 70 [95% CI, 0.68-0.73]). The CAIDE and LIBRA also provided similar but lower AUCs than the 3 aforementioned tools (eg, MAP cohort: CAIDE AUC, 0.50 [95% CI, 0.46-0. ...

Tópico(s): Chronic Disease Management Strategies

2023 - American Medical Association | JAMA Network Open

Artigo Acesso aberto Revisado por pares

Mika Kivimäki, Gill Livingston, Archana Singh‐Manoux, Nina Mars, Joni V. Lindbohm, Jaana Pentti, Solja T. Nyberg, Matti Pirinen, Emma L. Anderson, Aroon D. Hingorani, Pyry N. Sipilä,

... scores: the Cardiovascular Risk Factors, Aging and Dementia (CAIDE)-Clinical score, the CAIDE– APOE -supplemented score, the Brief Dementia Screening Indicator ( ... false positives ranged between 1 to 66 (for CAIDE– APOE -supplemented) and 1 to 116 (for ANU- ... 95% CI, 0.65-0.67) for the CAIDE clinical version, 0.73 (95% CI, 0.72-0.73) for the CAIDE– APOE -supplemented, 0.68 (95% CI, 0.67- ...

Tópico(s): Frailty in Older Adults

2023 - American Medical Association | JAMA Network Open

Artigo Acesso aberto Revisado por pares

Rong Hua, Jianhao Xiong, Gail Li, Yidan Zhu, Zongyuan Ge, Yanjun Ma, Meng Fu, Chenglong Li, Bin Wang, Li Dong, Xin Zhao, Zhiqiang Ma, Jili Chen, Xinxiao Gao, Chao He, Zhaohui Wang, Wenbin Wei, Fei Wang, Xiangyang Gao, Yuzhong Chen, Qiang Zeng, Wuxiang Xie,

... Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score is a recognised tool for ... algorithm based on fundus photographs for estimating the CAIDE dementia risk score was developed and internally validated ... performance for identifying individuals with high dementia risk (CAIDE dementia risk score ≥ 10 points) was evaluated by ... in the external group, respectively. Besides, the estimated CAIDE dementia risk score derived from the algorithm was ...

Tópico(s): Retinal Imaging and Analysis

2022 - Oxford University Press | Age and Ageing

Artigo Acesso aberto Revisado por pares

Timo Pekkala, Anette Hall, Jyrki Lötjönen, Jussi Mattila, Hilkka Soininen, Tiia Ngandu, Tiina Laatikainen, Miia Kivipelto, Alina Solomon,

... State Index (DSI), in the Finnish population-based CAIDE study.Methods: The CAIDE study was based on previous population-based midlife surveys.CAIDE participants were re-examined twice in late-life, ...

Tópico(s): Chronic Disease Management Strategies

2016 - IOS Press | Journal of Alzheimer s Disease

Artigo Acesso aberto Revisado por pares

Stephanie Torres, Angel M. Alexander, Sid E. O’Bryant, Luis D. Medina,

... L). The Cardiovascular Risk Factors, Aging and Dementia (CAIDE), Framingham Risk Score (FRS), and Washington Heights-Inwood ... by FRS: β= –0.08, p = 0.022; CAIDE: β= –0.08, p < 0.001; and WHICAP: ... by FRS: β= –0.11, p < 0.001; CAIDE: β= –0.14, p < 0.001; and WHICAP: ... t(246) = –4.61, p < 0.001] and CAIDE [t(420) = –3.20, p = 0.001], but ...

Tópico(s): Health disparities and outcomes

2020 - IOS Press | Journal of Alzheimer s Disease

Artigo Acesso aberto Revisado por pares

Mariagnese Barbera, Jenni Kulmala, Inna Lisko, Eija Pietilä, Anna Rosenberg, Ilona Hallikainen, Merja Hallikainen, Tiina Laatikainen, Jenni Lehtisalo, Elisa Neuvonen, Minna Rusanen, Hilkka Soininen, Jaakko Tuomilehto, Tiia Ngandu, Alina Solomon, Miia Kivipelto,

... whole. The Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study investigated risk factors and determinants of cognitive ... CAIDE85+ is the third follow-up of the CAIDE study participants. All individuals still alive and living ... Joensuu areas of Eastern Finland, from the original CAIDE cohort (two random samples, N = 2000 + ~ 900), will ...

Tópico(s): Nutritional Studies and Diet

2020 - BioMed Central | BMC Geriatrics

Artigo Acesso aberto Revisado por pares

Christopher L. Schaich, Joseph Yeboah, Mark A. Espeland, Laura D. Baker, Jingzhong Ding, Kathleen M. Hayden, Bonnie C. Sachs, Suzanne Craft, Stephen R. Rapp, José A. Luchsinger, Annette L. Fitzpatrick, Susan R. Heckbert, Wendy S. Post, Gregory L. Burke, Norrina B. Allen, Timothy M. Hughes,

... Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE), Framingham Stroke Risk Profile (FSRP), and atherosclerotic cardiovascular ... risk score were associated with worse cognitive performance. CAIDE had stronger associations with CASI performance than the ... with the DSC and DS were similar to CAIDE (difference in β [95% CI] = -0.57 [-1. ... Race/ethnicity modified associations. For example, associations between CAIDE and CASI were greater in African Americans and ...

Tópico(s): Cerebrovascular and Carotid Artery Diseases

2021 - Oxford University Press | The Journals of Gerontology Series A

Artigo Acesso aberto Revisado por pares

Magdalena I. Tolea, Jaeyeong Heo, Stephanie Chrisphonte, James E. Galvin,

... score system, Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) was derived using midlife risk factors in a ... always available. Objective: Develop and validate a modified CAIDE (mCAIDE) system and test its ability to predict ... independent clinical sample. Validity against Framingham, Hachinski, and CAIDE risk scores was assessed. Results: Higher mCAIDE quartiles ...

Tópico(s): Nutritional Studies and Diet

2021 - IOS Press | Journal of Alzheimer s Disease

Artigo Revisado por pares

Jenni Kulmala, Alina Solomon, Ingemar Kåreholt, Tiia Ngandu, Taina Rantanen, Tiina Laatikainen, Hilkka Soininen, Jaakko Tuomilehto, Miia Kivipelto,

... Cardiovascular risk factors, ageing and incidence of dementia (CAIDE) study.Subjects were selected from four independent, random ... they were on average 50 years old. The CAIDE target population included 3559 individuals. A random sample ...

Tópico(s): Nutrition and Health in Aging

2014 - Wiley | Journal of Internal Medicine

Artigo Acesso aberto Revisado por pares

Kaarin J. Anstey, Nicolas Cherbuin, Pushpani Herath, Chengxuan Qiu, Lewis H. Kuller, Oscar L. López, R. J. Wilson, Laura Fratiglioni,

... from the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study for middle-aged cohorts. Methods This study ... individual participants for the ANU-ADRI and the CAIDE index. Results For the ANU-ADRI using available ... for MAP, KP and CVHS respectively. Results for CAIDE ranged from c-statistics of 0.488 (0. ...

Tópico(s): Frailty in Older Adults

2014 - Public Library of Science | PLoS ONE

Editorial Acesso aberto Revisado por pares

Maurizio Paciaroni, Julien Bogousslavsky,

... dementia among patients with coronary artery diseases using CAIDE score, F1000Research, 10.12688/f1000research.25388.2, 9, ( ... dementia among patients with coronary artery diseases using CAIDE score, F1000Research, 10.12688/f1000research.25388.3, 9, ( ... dementia among patients with coronary artery diseases using CAIDE score, F1000Research, 10.12688/f1000research.25388.1, 9, ( ...

Tópico(s): Blood Pressure and Hypertension Studies

2013 - Wiley | Journal of the American Heart Association

Artigo Revisado por pares

Miika Vuorinen, Gabriela Spulber, Soheil Damangir, Eini Niskanen, Tiia Ngandu, Hilkka Soininen, Miia Kivipelto, Alina Solomon,

Background: CAIDE Dementia Risk Score is a validated tool for estimating 20-year dementia risk in the general population ... risk profile. Objective: To investigate the associations between CAIDE score and dementia-related brain change

Tópico(s): Neurological Disease Mechanisms and Treatments

2015 - IOS Press | Journal of Alzheimer s Disease