Produção Nacional
Revisado por pares
Caio Castro, Daniela Vieira Fernandes, M. H. Siqueira Mendonça, Décio Roveda, Gustavo Machado Badan, Eduardo de Faria Castro Fleury,
... breast implant capsule mimicking anaplastic large cell lymphoma Caio Castro MD, Corresponding Author Caio Castro MD caio.vcastro@gmail.com orcid.org/0000- ... Misericordia de Sao Paulo, Sao Paulo, Brazil Correspondence Caio Castro, Radiologia e Diagnostico por imagem, Irmandade da Santa ... Paulo, BrazilSearch for more papers by this author Caio Castro MD, Corresponding Author Caio Castro MD caio.vcastro@gmail.com orcid.org/0000- ... Misericordia de Sao Paulo, Sao Paulo, Brazil Correspondence Caio Castro, Radiologia e Diagnostico por imagem, Irmandade da Santa ...
Tópico(s): Cancer Diagnosis and Treatment
2019 - Wiley | The Breast Journal
Produção Nacional
Revisado por pares
Caio César Silva de Castro, Hélio Amante Miot,
... resource for physicians and public health officials alike. Caio Castro and Helio Miot declare no conflict of interests.
Tópico(s): Olfactory and Sensory Function Studies
2017 - Wiley | Pigment Cell & Melanoma Research
Caio Castro Freire, Melissa Bars Closel, Érica Hasui, Flávio Nunes Ramos,
The aim of this study was to evaluate Syagrus romanzoffiana (Arecaceae) (1) reproductive phenology, (2) seed dispersal and (3) seed predation in a highly fragmented landscape. Over a 24-month period, we recorded flowering and fruiting events, proportions of fallen fruit infested by insects, as well as seed dispersal and seed predation by squirrels. Overall flowering and fruiting intensities varied among months; flowering being significantly greater in January and March 2008, and fruiting in April–June ...
Tópico(s): Animal Ecology and Behavior Studies
2013 - Finnish Zoological and Botanical Publishing Board | Annales Botanici Fennici
Produção Nacional
Revisado por pares
Louyse D. Correia, Caio César Silva de Castro,
... Author Caio C. Silva de Castro MD, PhD caio.castro@pucpr.br orcid.org/0000-0001-9767-5765 ... Zip Code: 80215-901, Curitiba Brazil E-mail: caio.castro@pucpr.brSearch for more papers by this author ... Author Caio C. Silva de Castro MD, PhD caio.castro@pucpr.br orcid.org/0000-0001-9767-5765 ... Zip Code: 80215-901, Curitiba Brazil E-mail: caio.castro@pucpr.brSearch for more papers by this author ...
Tópico(s): Autoimmune Bullous Skin Diseases
2018 - Wiley | International Journal of Dermatology
Produção Nacional
Revisado por pares
Viktoria Eleftheriadou, Kim S Thomas, Nanja van Geel, Iltefat Hamzavi, Henry W. Lim, Tamio Suzuki, Ichiro Katayama, Tag S. Anbar, Marwa Abdallah, Laïla Benzekri, Yvon Gauthier, John E. Harris, Caio César Silva de Castro, Amit G. Pandya, Boon Kee Goh, Cheng‐Che E. Lan, Naoki Oiso, Ahmed A. Issa, Samia Esmat, Caroline Le Poole, Ai‐Young Lee, Davinder Parsad, Alain Taı̈eb, Mauro Picardo, Khaled Ezzedine,
... more papers by this authorCaio Cesar Silva de Castro, Caio Cesar Silva de Castro Department of Dermatology, Pontifícia ... more papers by this authorCaio Cesar Silva de Castro, Caio Cesar Silva de Castro Department of Dermatology, Pontifícia Universidade Católica do Paraná, ...
Tópico(s): Delphi Technique in Research
2015 - Wiley | Pigment Cell & Melanoma Research
Produção Nacional
Revisado por pares
Paulo Müller Ramos, Mayra Ianhez, Caio César Silva de Castro, Carolina Talhari, Paulo Ricardo Criado, Hélio Amante Miot,
... this authorCaio Cesar Silva de Castro MD, PhD, Caio Cesar Silva de Castro MD, PhD orcid.org/0000-0001-9767-5765 ... this authorCaio Cesar Silva de Castro MD, PhD, Caio Cesar Silva de Castro MD, PhD orcid.org/0000-0001-9767-5765 ...
Tópico(s): Burn Injury Management and Outcomes
2022 - Wiley | International Journal of Dermatology
Produção Nacional
Revisado por pares
Licia dos Reis Luz, Diogo Denardi Porto, Caio B. Castro, Maria Francilene Souza Silva, Elenilson G. Alves Filho, Kirley Marques Canuto, Edy Sousa de Brito, Helena Becker, Cláudia Pessoa, Guilherme Julião Zocolo,
Schinopsis brasiliensis is a plant typically found in the caatinga biome (northeastern Brazil). Its leaves and bark have been used for the treatment of health dysfunctions such as cough, influenza, diarrhea, throat inflammation, and sexual impotence. However, there is a lack of knowledge regarding the chemical composition and pharmacological activities of this plant. High-performance liquid chromatography coupled to high-resolution mass spectrometry (UPLC-QTOF-MSE) allowed the partial identification ...
Tópico(s): Natural product bioactivities and synthesis
2018 - Elsevier BV | Journal of Chromatography B
Produção Nacional
Revisado por pares
Isabella Michelon, Maysa Vilbert, Alice Deberaldini Marinho, Caio Castro, Maria Inez Dacoregio, Carlos Stecca, Leonardo Ribeiro Soares, Marta Vaz Batista, Sofía Braga, Anwaar Saeed, Ludimila Cavalcante,
•Patients with advanced HER2+ BC often develop BMs.•Our meta-analysis included 319 patients with BMBC treated with T-DXd from 10 studies.•We found an IC-ORR of 61% and an IC-CBR of 70%.•ORR was 68% in patients with stable BM and 60% in those with active BM (P = 0.35).•The median progression-free survival for patients with BMBC treated with T-DXd was 15 months. BackgroundTrastuzumab deruxtecan (T-DXd) has shown promising results in patients with breast cancer brain metastases (BCBMs). We conducted a systematic ...
Tópico(s): Lung Cancer Research Studies
2024 - Elsevier BV | ESMO Open
Caio B. Castro, Lícia R. Luz, Jhonyson Arruda Carvalho Guedes, Diogo Denardi Porto, Maria Francilene Souza Silva, Gisele da Silva, Paulo Riceli Vasconcelos Ribeiro, Kirley Marques Canuto, Edy Sousa de Brito, Dávila Zampieri, Cláudia Pessoa, Guilherme Julião Zocolo,
Myracrodruon urundeuva ("aroeira-do-sertão") is a species threatened with extinction due to anthropogenic exploitation.Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids.Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2019 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Revisado por pares
Caio P. de Castro, Thiago A. de Assis, Roberto Rivelino, F. de Brito Mota, C.M.C. de Castilho, Richard G. Forbes,
In many field electron emission experiments on single-walled carbon nanotubes (SWCNTs), the SWCNT stands on one of two well-separated parallel plane plates, with a macroscopic field FM applied between them. For any given location "L" on the SWCNT surface, a field enhancement factor (FEF) is defined as $F_{\rm{L}}$/$F_{\rm{M}}$, where $F_{\rm{L}}$ is a local field defined at "L". The best emission measurements from small-radii capped SWCNTs exhibit characteristic FEFs that are constant (i.e., independent ...
Tópico(s): Molecular Junctions and Nanostructures
2019 - American Chemical Society | Journal of Chemical Information and Modeling
Produção Nacional
Revisado por pares
Ana F. Almeida‐Santos, Vinícius Rezende Carvalho, Laura F. Jaimes, Caio M. de Castro, Hyorrana Priscila Pereira Pinto, Tadeu P. D. Oliveira, Luciene Bruno Vieira, Márcio Flávio Dutra Moraes, Grace Schenatto Pereira,
The absence of companion may jeopardize mental health in social animals. Here, we tested the hypothesis that social isolation impairs social recognition memory by altering the excitability and the dialog between the olfactory bulb (OB) and the dorsal hippocampus (dHIP). Adult male Swiss mice were kept grouped (GH) or isolated (SI) for 7 days. Social memory (LTM) was evaluated using social recognition test. SI increased glutamate release in the OB, while decreased in the dHIP. Blocking AMPA and NMDA receptors ...
Tópico(s): Memory and Neural Mechanisms
2019 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Juliane F. Oliveira, Daniel Cardoso Pereira Jorge, Rafael Veiga, Moreno S. Rodrigues, Matheus F. Torquato, Nívea B. da Silva, Rosemeire Leovigildo Fiaccone, Luciana Lobato Cardim, Felipe Augusto Pereira, Caio P. de Castro, Aureliano S. S. Paiva, Alan A. S. Amad, Ernesto A. B. F. Lima, Diego S. Souza, Suani T. R. Pinho, Pablo Ivan Pereira Ramos, Roberto F. S. Andrade,
Abstract COVID-19 is affecting healthcare resources worldwide, with lower and middle-income countries being particularly disadvantaged to mitigate the challenges imposed by the disease, including the availability of a sufficient number of infirmary/ICU hospital beds, ventilators, and medical supplies. Here, we use mathematical modelling to study the dynamics of COVID-19 in Bahia, a state in northeastern Brazil, considering the influences of asymptomatic/non-detected cases, hospitalizations, and ...
Tópico(s): COVID-19 and Mental Health
2021 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
Usama Bilal, Caio P. de Castro, Tania Alfaro, Tonatiuh Barrientos‐Gutiérrez, Maurício L. Barreto, Carlos M. Leveau, Kevin Martínez-Folgar, J. Jaime Miranda, Felipe Montes, Pricila H. Mullachery, Maria de Fátima de Pina, Daniel A. Rodrı́guez, Gervásio Ferreira dos Santos, Roberto F. S. Andrade, Ana V. Diez Roux,
The scaling of mortality in cities of the Americas varies widely by cause and region.
Tópico(s): Global Health Care Issues
2021 - American Association for the Advancement of Science | Science Advances
Produção Nacional
Revisado por pares
Maria Izabel dos Santos, Gervásio Ferreira dos Santos, Anderson Freitas, José Firmino de Sousa Filho, Caio P. de Castro, Aureliano S. S. Paiva, Amélia Augusta de Lima Friche, Sharrelle Barber, Waleska Teixeira Caiaffa, Maurício L. Barreto,
This paper investigates the associations of income segregation with homicide mortality across 152 cities in Brazil. Despite GDP increases, an important proportion of the Brazilian population experiences poverty and extreme poverty. Segregation refers to the way that different groups are located in space based on their socioeconomic status, with groups defined based on education, unemployment, race, age, or income levels. As a measure of segregation, the dissimilarity index showed that overall, it ...
Tópico(s): Homelessness and Social Issues
2021 - Elsevier BV | SSM - Population Health
Produção Nacional
Revisado por pares
Caio B. Castro, Millena P. Ferreira, Caterina G. C. Marques Netto,
Metalloenzymes are involved in several different reactions and the metal can display distinct roles, such as redox chemistry or substrate activation. The activation mechanism is mainly described to occur by bond polarization upon coordination to the metal center. However, the disregard of the outer sphere mechanism can have a profound impact on the mechanism proposition of reactions. In the outer sphere coordination, the metal acts as an electrostatic activator in its hydrated form. Since hydration ...
Tópico(s): Metalloenzymes and iron-sulfur proteins
2021 - Elsevier BV | Current Research in Chemical Biology
Produção Nacional
Revisado por pares
Luciana Melo Pereira, Caio M. de Castro, Lorena Terene Lopes Guerra, Thaís Muniz de Queiroz, João T. Marques, Grace Schenatto Pereira,
Tópico(s): Stress Responses and Cortisol
2019 - Springer Science+Business Media | Molecular Neurobiology
Produção Nacional
Revisado por pares
Eduardo de Faria Castro Fleury, Caio Castro, Mario Sergio Campos do Amaral, Décio Roveda,
According to the Breast Imaging and Reporting Data System (BI-RADS), one of the main limitations of MRI is diagnosing the non-mass enhancement (NME). The NME lesion is challenging since it is unique to the MRI lexicon. This study aims to report our experience with NME lesions diagnosed by MRI referred for MRI-guided biopsies and discuss the management and follow-up of these lesions.We retrospectively evaluated all MRI-guide breast biopsies. We included all patients referred for NME breast MRI-guided ...
Tópico(s): Breast Lesions and Carcinomas
2022 - SAGE Publishing | Breast Cancer Basic and Clinical Research
Produção Nacional
Revisado por pares
Dieric S. Abreu, Ticyano P. de Sousa, Caio B. Castro, Mayara N.V. Sousa, Thiago T. Silva, Francisco Wagner Queiroz Almeida-Neto, Marcos Vinícius Aquino Queirós, Bárbara Suellen Ferreira Rodrigues, Maria da Conceição Ferreira de Oliveira, Tércio de F. Paulo, Benildo Sousa Cavada, Kyria Santiago Nascimento, Márcia L. A. Temperini, Izaura C.N. Diógenes,
We report the successful fabrication of a novel gold surface coated with a thiol-lectin multilayer that showed specific interaction towards D-mannose sugars. Firstly, the gold surface was spontaneously modified with gliotoxin (gtx), a sulfur containing diketopiperazine isolated from marine-derived fungus, and fully characterized by electrochemical, EIS, SPR and SERS techniques. The results indicated the sulfur bridge of gtx is broken upon adsorption and the molecules are flat lying on gold with surface ...
Tópico(s): Analytical Chemistry and Sensors
2017 - Elsevier BV | Electrochimica Acta
Produção Nacional
Ticianne da Cunha Soares, Luana Carla Braga Santana, Tamires da Cunha Soares, João Caio Silva Castro Ferreira, Ariella de Carvalho Luz, Maria de Fátima Sousa Barros Vilarinho, Jéssica Denise Vieira Leal, Victor Alves de Oliveira, Joice Rodrigues de Almeida, Vitória Silva de Araújo, Renato Felipe de Andrade,
Objective: To analyze the risk factors related to pre-eclampsia. Method: Integrative review of the literature that investigated studies that addressed the theme of risk factors related to PE. All articles in English and Portuguese published between 2005 and 2018. Results: It was observed that the risk factors for PE found: sociodemographic factors, family history of PE, personal history of PE, elevated pre-gestational BMI, gestational weight gain above expectations, extremes of reproductive age, ...
Tópico(s): Global Maternal and Child Health
2019 - Revista Eletronica Acervo Saude | Revista Eletrônica Acervo Saúde
Produção Nacional
Revisado por pares
Caio P. de Castro, Mirko Luković, Roberto F. S. Andrade, Hartmut Herrmann,
Many examples of natural systems can be described by random Gaussian surfaces. Much can be learned by analyzing the Fourier expansion of the surfaces, from which it is possible to determine the corresponding Hurst exponent and consequently establish the presence of scale invariance. We show that this symmetry is not affected by the distribution of the modulus of the Fourier coefficients. Furthermore, we investigate the role of the Fourier phases of random surfaces. In particular, we show how the ...
Tópico(s): Stochastic processes and statistical mechanics
2017 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Gerson Dellatorre, Daniela Alves Pereira Antelo, Roberta Buense Bedrikow, Tânia Ferreira Cestari, Ivonise Follador, Daniel Gontijo Ramos, Caio César Silva de Castro,
Vitiligo is a muco-cutaneous, autoimmune, localized, or disseminated disease, which manifests through hypochromic or achromic macules, with loss in quality of life. The prevalence of vitiligo in Brazil was determined to be 0.54%. There is no on-label medication for its treatment. To date, no Brazilian consensus on the treatment of vitiligo had been written. The objective of this group of Brazilian dermatologists with experience in the treatment of this disease was to reach a consensus on the clinical ...
Tópico(s): Skin Protection and Aging
2020 - Elsevier BV | Anais Brasileiros de Dermatologia
Produção Nacional
Revisado por pares
Melpone Komnitski, Angelo Komnitski, Amilton Komnitski, Caio César Silva de Castro,
Vitiligo is a disease that causes macules and achromic and/or hypochromic patches, which can affect from small areas to the entire tegument. Treatment options are few and are generally ineffective. Recently, some case reports have appeared which show positive results with the use of Janus kinase inhibitors associated with phototherapy. This report details the case of a patient with rheumatoid arthritis associated with vitiligo in treatment for two years, whose condition partially improved initially ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2020 - Elsevier BV | Anais Brasileiros de Dermatologia
Produção Nacional
Revisado por pares
Caio César Silva de Castro, Liliane Machado do Nascimento, Gaby Walker, Renata Iani Werneck, Everson Nogoceke, Marcelo Távora Mira,
Vitiligo is a chronic disease characterized by macules devoid of melanin and identifiable melanocytes. Adhesion of melanocytes to the basement membrane by integrin CCN3 is mediated through collagen IV receptor DDR1. We hypothesize that genetic variants of the DDR1 gene are associated with the occurrence of vitiligo. To test this hypothesis, we genotyped 10 DDR1 tag single-nucleotide polymorphisms (SNPs) in 212 trios composed of an affected child and both parents. Associated markers were then genotyped ...
Tópico(s): Cell Adhesion Molecules Research
2010 - Elsevier BV | Journal of Investigative Dermatology
Produção Nacional
Revisado por pares
Caio César Silva de Castro, Liliane Machado do Nascimento, Márcia Olandoski, Marcelo Távora Mira,
Background Vitiligo classification systems are often based exclusively on the number and distribution of the white patches. To what extend these classification protocols reflect possible different pathophysiological basis for vitiligo or carry any prognostic value is currently unknown. Objective To investigate patterns of association between type of vitiligo and common disease-related variables, in order to advance on the understanding of the exact nature of different clinical forms of disease, ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2011 - Elsevier BV | Journal of Dermatological Science
Produção Nacional
Revisado por pares
Adriane Reichert-Faria, J Jung, Victor Moreschi Neto, Caio César Silva de Castro, Marcelo Távora Mira, Lúcia de Noronha,
Journal of the European Academy of Dermatology and VenereologyVolume 27, Issue 8 p. 1057-1059 LETTERS TO THE EDITOR Reduced immunohistochemical expression of Discoidin Domain Receptor 1 (DDR1) in vitiligo skin A. Reichert-Faria, Corresponding Author A. Reichert-Faria Department of Dermatology, Santa Casa de Misericórdia Hospital, School of Medicine, Pontifical Catholic University of Paraná, Curitiba Adriane Reichert Faria. E-mail: adri_reichert@yahoo.com.brSearch for more papers by this authorJ.E. ...
Tópico(s): Mast cells and histamine
2012 - Wiley | Journal of the European Academy of Dermatology and Venereology
Produção Nacional
Revisado por pares
Adriane Reichert Faria, Roberto Gomes Tarlé, Gerson Dellatorre, Marcelo Távora Mira, Caio César Silva de Castro,
In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the lesions are CD4+ and CD8+ T lymphocytes. Physical and pharmacological treatment strategies aim to control the autoimmune damage and stimulate melanocyte migration from the unaffected ...
Tópico(s): Skin Protection and Aging
2014 - Elsevier BV | Anais Brasileiros de Dermatologia
Produção Nacional
Revisado por pares
Roberto Gomes Tarlé, Liliane Machado do Nascimento, Marcelo Távora Mira, Caio César Silva de Castro,
Vitiligo is a chronic stigmatizing disease, already known for millennia, which mainly affects melanocytes from epidermis basal layer, leading to the development of hypochromic and achromic patches. Its estimated prevalence is 0.5% worldwide. The involvement of genetic factors controlling susceptibility to vitiligo has been studied over the last decades, and results of previous studies present vitiligo as a complex, multifactorial and polygenic disease. In this context, a few genes, including DDR1, ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2014 - Elsevier BV | Anais Brasileiros de Dermatologia
Produção Nacional
Revisado por pares
Roberto Gomes Tarlé, Caio César Silva de Castro, Liliane Machado do Nascimento, Marcelo Távora Mira,
Vitiligo is a depigmenting disorder characterized by loss of functional melanocytes from the epidermis. Experimental data suggest that defective melanocyte adhesion may underlie the pathogenesis of the disease. In particular, association between vitiligo and genetic variants of the DDR1 gene involved in melanocyte adhesion has been recently published. A subsequent, independent study revealed lower expression of DDR1 in vitiligo lesions. Here, we expand this investigation by testing for association ...
Tópico(s): Mast cells and histamine
2015 - Wiley | Experimental Dermatology
Produção Nacional
Revisado por pares
Katiucia Rocha, Mariana Carolina Piccinin, Luciana F. Kalache, Adriane Reichert-Faria, Caio César Silva de Castro,
We report the case of a 25-year-old patient who became pregnant during ustekinumab therapy. Treatment was suspended immediately after pregnancy had been confirmed. The patient had an uneventful pregnancy and her child is currently 14 months old, with adequate development to her age. Four reports of pregnancy during ustekinumab treatment have been reported and one resulted in miscarriage.
Tópico(s): Eosinophilic Esophagitis
2015 - Karger Publishers | Dermatology
Produção Nacional
Revisado por pares
Adriane Reichert Faria, Juliana Elizabeth Jung, Caio César Silva de Castro, Lúcia de Noronha,
Because defects in adhesion impairment seem to be involved in the etiopathogenesis of vitiligo, this study aimed to compare the immunohistochemical expression of several adhesion molecules in the epidermis of vitiligo and non lesional vitiligo skin. Sixty-six specimens of lesional and non lesional skin from 33 volunteers with vitiligo were evaluated by immunohistochemistry using anti-beta-catenin, anti-E-cadherin, anti-laminin, anti-beta1 integrin, anti-collagen IV, anti-ICAM-1 and anti-VCAM-1 antibodies. ...
Tópico(s): Glycosylation and Glycoproteins Research
2016 - Elsevier BV | Pathology - Research and Practice