Dake Huang, Fillan S. Grady, Lila Peltekian, Justin J. Laing, Joel C. Geerling,
... neurons form many subpopulations, one of which expresses Calca, which encodes the neuropeptide calcitonin gene-related peptide (CGRP). This Calca-expressing subpopulation has been implicated in a variety of homeostatic functions, but the overall distribution of Calca-expressing neurons in this region remains unclear. Also, ... have identified output projections from CGRP-immunoreactive or Calca-expressing neurons, we lack a comprehensive understanding of ... efferent projections. We began by identifying neurons with Calca mRNA and CGRP immunoreactivity in and around the ...
Tópico(s): Sleep and Wakefulness Research
2021 - Wiley | The Journal of Comparative Neurology
Produção Nacional
Revisado por pares
Cleber Camacho, Susan C. Lindsey, Maria Clara C. Melo, Ji H. Yang, Fausto Germano‐Neto, Flávia de O.F. Valente, Thiago Rosa Lima, Rosa Paula M. Biscolla, José Gilberto H. Vieira, Janete M. Cerutti, Magnus R. Dias‐da‐Silva, Rui M. B. Maciel,
... the applicability of measuring calcitonin-related polypeptide alpha (CALCA) gene transcripts (CT-CALCA and calcitonin gene-related peptide [CGRP]-CALCA) in patients with MTC and in relatives diagnosed ... primer for the two specific mRNA targets (CT-CALCA or CGRP-CALCA) and normalized with the ribosomal protein S8 as the reference gene.We detected CALCA transcripts in the blood samples and observed a ... 0001). Both mRNAs also correlated with sCT (CT-CALCA, r=0.713, p<0.0001; CGRP-CALCA, r=0.714, p<0.0001). The relative ...
Tópico(s): Pituitary Gland Disorders and Treatments
2012 - Mary Ann Liebert, Inc. | Thyroid
Max Daniel Kauther, Hagen S. Bachmann, Laura Neuerburg, Martina Broecker‐Preuss, Gero Hilken, Florian Grabellus, Gabriele Koehler, Marius von Knoch, Christian Wedemeyer,
... in-vivo circumstances on particle-induced osteolysis in Calca -/- mice.We used the murine calvarial osteolysis model ... C57BL/6J wild-type (WT) mice and twenty Calca -/- mice. The mice were divided into six groups: ... Group 1), WT with UHMWPE particles (Group 2), Calca -/- mice without UHMWPE particles (Group 3), Calca -/- mice with UHMWPE particles (Group 4), Calca -/- mice without UHMWPE particles and calcitonin substitution (Group 5), and Calca -/- mice with UHMWPE particle implantation and calcitonin substitution ( ... TRACP) + cells.Bone resorption was significantly increased in Calca -/- mice compared with their corresponding WT. The eroded ...
Tópico(s): Total Knee Arthroplasty Outcomes
2011 - BioMed Central | BMC Musculoskeletal Disorders
Yuan-Lin Dong, Deepti M. Reddy, Kortney E. Green, Madhu Chauhan, Hui-Qun Wang, Manubai Nagamani, Gary D.V. Hankins, Chandra Yallampalli,
... knockout of gene for calcitonin gene-related peptide (CALCA) receptor component, calcitonin receptor-like receptor (CALCRL), led ... and embryonic death, underlining the critical role of CALCA in embryonic development and fetal growth. The present ... was designed to determine the cellular localization of CALCA and its receptor components, CALCRL and receptor activity ... implantation site during early pregnancy; to assess whether CALCA regulates in vitro angiogenesis of human endothelial cells; and to examine whether CALCA can improve angiogenic imbalance in preeclamptic placental explants. ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2007 - Oxford University Press | Biology of Reproduction
Susan M. Krzysik-Walker, Olga M. Ocón-Grove, Sreenivasa B. Maddineni, Gilbert L. Hendricks, Ramesh Ramachandran,
Calcitonin (CALCA), a hormone primarily known for its role in calcium homeostasis, has recently been linked to reproduction, specifically ... marker for embryo implantation in the uterus. Although CALCA expression has been documented in several tissues, there has been no report of production of CALCA in the ovary of any vertebrate species. We hypothesized that the Calca gene is expressed in the chicken ovary, and ... gonadal steroid administration. Using RT-PCR, we detected Calca mRNA and the calcitonin receptor (Calcr) mRNA in ...
Tópico(s): Estrogen and related hormone effects
2007 - Oxford University Press | Biology of Reproduction
Renjie Sun, Guoyu Zhou, Lihua Liu, Lijun Ren, Yu Xi, Jingyuan Zhu, Hui Huang, Zhiyuan Li, Yan Li, Xuemin Cheng, Yue Ba,
... been reported to affect bone mineral density (BMD). CALCA expression plays a critical part in bone formation. However, the role of CALCA in the association between fluoride and BMD is ... China, to assess the relationship between fluoride exposure, CALCA methylation, and BMD. Urinary levels of fluoride, CALCA methylation, and BMD were measured by a fluoride ... chain reaction, respectively. The association among fluoride exposure, CALCA methylation, and BMD was age-specific. Specifically, BMD ... the interactive effect of the highest methylation of CALCA exon 1 (tertile 3) and fluoride exposure was ...
Tópico(s): Nutritional Studies and Diet
2020 - Elsevier BV | Chemosphere
Eva Tavares, Rosário Maldonado, F.J. Miñano,
... 20 hours after CLP. High expressions of the CALCA gene, procalcitonin, and NPCT were detected in the ... sepsis. Immunoneutralization of NPCT decreased pulmonary levels of CALCA, procalcitonin, and NPCT; reduced lung inflammation and injury, ... 20 hours after CLP. High expressions of the CALCA gene, procalcitonin, and NPCT were detected in the ... sepsis. Immunoneutralization of NPCT decreased pulmonary levels of CALCA, procalcitonin, and NPCT; reduced lung inflammation and injury, ... Google Scholar ProCT is encoded by the human CALCA gene located on chromosome 11.16Steenbergh P.H. ...
Tópico(s): Neuropeptides and Animal Physiology
2014 - Elsevier BV | American Journal Of Pathology
Marc T. Goodman, Robert E. Ferrell, Katharine McDuffie, Pamela J. Thompson, Lynne R. Wilkens, Abigail W. Bushley, Ko-Hui Tung, Michael E. Carney, Roberta B. Ness,
... p. 53-58 Research Article Calcitonin gene polymorphism CALCA-624 (T/C) and ovarian cancer† Marc T. ... 2002. Am J Epidemiol 156:148–57). The CALCA gene codes for calcitonin, an important regulator of ... 624) of the translation initiation codon of the CALCA gene influences the risk of ovarian malignancy. A ... with increasing intake of calcium. Women with any CALCA C allele were at nonsignificantly higher risk of ... significant positive association was found among Japanese for CALCA CT (OR: 2.3, 95% CI: 1.0–5.3) and CALCA CC (OR: 7.2, 95% CI: 1.1– ...
Tópico(s): Hormonal Regulation and Hypertension
2005 - Wiley | Environmental and Molecular Mutagenesis
Alexander Bartelt, Anke Jeschke, Brigitte Müller, Isabella Gaziano, Michelle Morales, Timur Yorgan, Timo Heckt, Markus Heine, Robert F. Gagel, Ronald B. Emeson, Michael Amling, Andreas Niemeier, Jörg Heeren, Thorsten Schinke, Johannes Keller,
... αCGRP), which are all encoded by the gene Calca. Here, we studied the role of Calca-derived peptides in diet-induced obesity (DIO) by challenging Calcr−/− (encoding the calcitonin receptor, CTR), Calca−/−, and αCGRP−/− mice and their respective littermates with ... and elevated HDL levels. In contrast, mice lacking Calca were protected from DIO, NASH and adipose tissue ... a significantly less improved DIO phenotype compared to Calca-deficient mice. In summary, we demonstrate that the ... is involved in regulating plasma cholesterol levels while Calca, presumably through PCT, seems to have a detrimental ...
Tópico(s): Hormonal Regulation and Hypertension
2017 - Public Library of Science | PLoS ONE
Thorsten Schinke, Sarah Liese, Matthias Priemel, Michael Haberland, Arndt F. Schilling, Philip Catalá-Lehnen, Dagmar Blicharski, Johannes M. Rueger, Robert F. Gagel, Ronald B. Emeson, Michael Amling,
... high bone mass phenotype in mice lacking the Calca gene that encodes CT and αCGRP. Here we ... that the high bone mass phenotype of the Calca-deficient mice is caused by the absence of ... physiologic functions that are both derived from the Calca gene by alternative splicing. We have recently described ... in mice carrying a targeted deletion of the Calca gene. To uncover whether this phenotype is caused ... is selectively abolished. Materials and Methods: Bones from Calca−/− mice, αCGRP−/− mice, and their corresponding wildtype controls ...
Tópico(s): S100 Proteins and Annexins
2004 - Oxford University Press | Journal of Bone and Mineral Research
Logan Condon, Ying Yu, Sekun Park, Feng Cao, Jordan L. Pauli, Tyler S. Nelson, Richard D. Palmiter,
... a role in nociplasticity. Here, by preventing PBN Calca neurons from releasing neurotransmitters, we demonstrate that activation of Calca neurons is necessary for the manifestation and maintenance of chronic pain. Additionally, by directly stimulating Calca neurons, we demonstrate that Calca neuron activity is sufficient to drive nociplasticity. Aversive ... or lithium chloride, can drive nociplasticity in a Calca-neuron-dependent manner. Aversive events drive nociplasticity in Calca neurons in the form of increased activity and ...
Tópico(s): Myofascial pain diagnosis and treatment
2024 - Cell Press | Cell Reports
... The protein expression of calcitonin/alpha-CGRP gene (CALCA), the miR-30a target gene, was detected by ... bilateral seizures, persistent pain and high pain index. CALCA was found to be the target gene of ... bioinformatics analysis. We verified that miR-30a degrades CALCA by dual-luciferase reporter assay. Western blot results ... that overexpression of miR-30a down-regulated the CALCA expression, and knockdown of miR-30a upregulated the CALCA expression. Conclusions Expression levels of miR-30a are ... and can relieve migraine through the degradation of CALCA.
Tópico(s): Medical Research and Treatments
2018 - Verduci Editore | European review for medical and pharmacological sciences
A MORITA, Toshinori Nakayama, Masayoshi Soma, Tetsuya Mizutani,
Calcitonin-related peptide α (CALCA) is a neuropeptide that is a very potent vasodilator. It has been reported that CALCA knockout mice have a significantly elevated systolic blood ... in the 5′ flanking region of the human CALCA gene in Japanese subjects and to assess the ... recruited. The 5′ flanking region of the human CALCA gene was searched to identify novel polymorphisms in ... 2-bp microdeletion polymorphism was discovered in the CALCA gene. Based on the results of the haplotype-based case control study, the CALCA gene could be the susceptibility gene for EH. ...
Tópico(s): Stress Responses and Cortisol
2007 - Oxford University Press | American Journal of Hypertension
Elisa Rubino, Silvia Boschi, Elisa Giorgio, Elisa Pozzi, Andrea Marcinnò, Erica Gallo, Fausto Roveta, Alberto Grassini, Alfredo Brusco, Innocenzo Rainero,
... CGRP), encoded by calcitonin gene-related peptide 1 (CALCA) gene, plays a key role in the disease. ... the study was to evaluate DNA methylation of CALCA gene in patients with episodic migraine. 22 patients ... two CpG islands in the promoter region of CALCA gene was analyzed. No difference of methylation of ... 30 CpG sites at the distal region of CALCA promoter was observed between migraineurs and controls. Interestingly, ... CpG sites at the proximal promoter region of CALCA is lower in migraineurs when compared to controls. ...
Tópico(s): Cognitive Functions and Memory
2022 - Elsevier BV | Neurobiology of Pain
Produção Nacional
Camila Maria da Silva Martinelli, André van Helvoort Lengert, Flavio Mavignier Cárcano, Eduardo Caetano Albino da Silva, Mariana Brait, Luiz Fernando Lopes, Daniel Onofre Vidal,
... methylation of a gene panel (VGF, MGMT, ADAMTS1, CALCA, HOXA9, CDKN2B, CDO1 and NANOG) was evaluated in ... 90.9%, 20/22; p=0.019) and CALCA (90.5%, 19/21; p<0.026) methylation was associated with non-seminomatous tumors while CALCA methylation was also associated with refractory disease (47. ... 3% vs 77.0%; p=0.029 for CALCA). The findings of this study indicate that methylation of MGMT and CALCA are frequent and could be used as new ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2016 - Impact Journals LLC | Oncotarget
Eman Abdel Rahman Ismail, Mahira I. Elmogy, Deena Samir Mohamed, Rania A. El-Farrash,
... one of the possible origins of leukemogenesis. Calcitonin (CALCA) gene is a hot-spot for gene hypermethylation ... aimed to systematically analyze the methylation status of CALCA gene in pediatric acute leukemia using methylation-specific ... AML) and 35 acute lymphoblastic leukemia (ALL) patients. CALCA gene was found to be hypermethylated in 54. ... of AML and 65.7% of ALL patients. CALCA hypermethylation was neither correlated to any of the ... groups (P<0.01). Our results suggest that CALCA gene methylation pattern is an independent prognostic factor ...
Tópico(s): Hemoglobinopathies and Related Disorders
2011 - Lippincott Williams & Wilkins | Journal of Pediatric Hematology/Oncology
Shruti Menon, J. Buteri, Bishakha Roy, Melanie Murrell, Sharon Quinlan, J. MacMillan, Rod A. Lea, Larisa M. Haupt, Lyn R. Griffiths,
... important role in migraine pathophysiology. Polymorphisms of the CALCA gene have been linked to Parkinson's disease, ... migraine, it is hypothesised that polymorphisms in the CALCA gene may play a role in migraine pathogenesis. ... bp deletion in the first intron of the CALCA gene has been reported to be a good ... of the 16 bp intronic deletion in the CALCA gene in migraineurs and matched control individuals. Six ... between the intronic 16 bp deletion in the CALCA gene and migraine in the tested Australian Caucasian ...
Tópico(s): Trigeminal Neuralgia and Treatments
2011 - Elsevier BV | Brain Research
Massimo Giunti, Angelo Peli, Mara Battilani, Silvia Zacchini, Gianfranco Militerno, Cynthia M. Otto,
To perform a qualitative evaluation of procalcitonin gene (CALCA) expression in a tissue-specific manner in dogs ... bacterial sepsis (n=3), or neoplasia (n=1). CALCA was amplified by PCR in the following samples: ... 4/9), liver (3/9). Only thyroid expressed CALCA in the 5 normal dogs.In SIRS, extrathyroidal transcription of CALCA was documented. Quantitative analysis (real-time polymerase chain ... extent and source of extrathyroidal expression of canine CALCA induced by septic and nonseptic systemic inflammation.
Tópico(s): Immune Response and Inflammation
2010 - Wiley | Journal of Veterinary Emergency and Critical Care
X.Y. Luo, Tianlun Yang, Xiaoping Chen, Yuan‐Jian Li,
... nucleotide polymorphisms (SNPs) in the genes coding for CALCA were associated with EH susceptibility in a Hunan ... blood leucocytes by a phenol-chloroform method. The CALCA T-692C was genotyped using a restriction fragment ... polymorphism method. Results A statistically significant difference in CALCA T-692C genotypic distribution was observed between cases ... 1.317-3.326, P <0.01). Conclusions CALCA genetic polymorphism is associated with EH susceptibility. Carriers ... least one C allele at the polymorphic site CALCA T-692C showed increased risk for EH.
Tópico(s): Biochemical effects in animals
2008 - Lippincott Williams & Wilkins | Chinese Medical Journal
Antje K. Huebner, Thorsten Schinke, Matthias Priemel, Sarah Schilling, Arndt F. Schilling, Ronald B. Emeson, Johannes M. Rueger, Michael Amling,
... still some controversy regarding its physiological function. Unexpectedly, Calca-deficient mice lacking CT and alpha-calcitonin gene- ... two mouse models, one lacking CT and alphaCGRP (Calca-/-), the other one lacking only alphaCGRP (alphaCGRP-/-).Bones from wildtype, Calca-/- -mice and alphaCGRP-/- -mice were analyzed at the ... display an osteopenia at all ages analyzed, the Calca-/- -mice develop a phenotype of high bone turnover ... bone formation and bone resorption specifically in the Calca-/- -mice. This severe phenotype that can result in ...
Tópico(s): Bone and Dental Protein Studies
2006 - Oxford University Press | Journal of Bone and Mineral Research
Shuhei Matsui, Megumu Tanaka, Akiko Kamiyoshi, Takayuki Sakurai, Yuka Ichikawa‐Shindo, Hisaka Kawate, Kun Dai, Nanqi Cui, Yangxuan Wei, Masaaki Tanaka, Shinji Kakihara, Keisei Nakamura, Akihiro Yamauchi, Kumiko Ishida, Satoshi Tanaka, Mikito Kawamata, Takayuki Shindo,
... the primary transcript of the calcitonin/CGRP gene (Calca). CGRP was initially identified as a neuropeptide released ... the primary transcript of the calcitonin/CGRP gene (Calca). CGRP was initially identified as a neuropeptide released ... the primary transcript of the calcitonin/CGRP gene (Calca).3Rosenfeld M.G. Mermod J.J. Amara S. ... mice (Figure 2D). The gene expression levels of Calca (CGRP), Adm (Adrenomedullin), Calcr (CLR), Ramp1, Ramp2, and ... tails of WT and CGRP−/− mice (Figure 3). Calca (CGRP) expression was significantly lower in CGRP−/− than ...
Tópico(s): Biomarkers in Disease Mechanisms
2019 - Elsevier BV | American Journal Of Pathology
Leonel Maldonado, Mariana Brait, Christina Michailidi, Enrico Munari, Tina Driscoll, Luciana Schultz, Trinity J. Bivalacqua, Mark Schoenberg, David Sidransky, George J. Netto, Mohammad Obaidul Hoque,
... genes ( ARF, TIMP3, RAR-β2, NID2, CCNA1, AIM1, CALCA and CCND2 ) by quantitative methylation specific PCR (QMSP) ... an empiric cutoff value, CCND2, CCNA1, NID2, and CALCA showed higher frequency of methylation in recurrent than ... vs. 3/17 (18%) (p=0.003) and CALCA 10/19 (53%) vs. 4/17 (23.5%) ( ... further analyzed PM of CCND 2, CCNA1 , and CALCA in urine DNA from UCC patients including LGPUCC and controls. The frequency of CCND2, CCNA1, and CALCA was significantly higher (p<0.0001) in urine ...
Tópico(s): Urinary and Genital Oncology Studies
2014 - Impact Journals LLC | Oncotarget
Babürhan Güldiken, Tammam Sipahi, Remziye Tekinarslan, Levent Kabayel, Hülya Özkan, Ayhan Ünlü, Bilge Eren Yamasan, Tulay Okman-Kilic, Nilda Turgut,
... investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine. Material and Methods: One ... into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase ... RFLP). Results: The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between ... no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity ... Our study did not show any association between CALCA T-692C gene polymorphism and migraine.
Tópico(s): Neurological Disorders and Treatments
2013 - Cambridge University Press | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Tulsi Mehta, Mohammad Obaidul Hoque, Richard Ugarte, M.H. Rahman, Edward S. Kraus, Robert A. Montgomery, Keith Melancon, David Sidransky, Hamid Rabb,
... aberrant methylation of two gene promoters (DAPK and CALCA) by quantitative methylation-specific polymerase chain reaction from ... more likely to have aberrant hypermethylation of the CALCA gene promoter in urine than healthy controls (100% vs 31%; P < .0001). There was increased CALCA hypermethylation in the urine of deceased versus living ... a trend toward increased aberrant hypermethylation of urine CALCA in patients with biopsy-proven acute tubular necrosis ... P = .67). However, there was no difference of CALCA hypermethylation in urine of patients with delayed graft ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2006 - Elsevier BV | Transplantation Proceedings
Lei Wang, Feng Ding, Shaojie Shi, Xingxing Wang, Sijia Zhang, Yingliang Song,
... fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied ... level of the target fragment and expression of Calca. We found that the DNA methylation level of target fragment of Calca in ASCs-T2DM was higher than that in ... that the reduction of the methylation level in Calca target fragment of ASCs-T2DM indeed escalated the ... the methylation level in the promoter region of Calca and then decrease the Calca expression. The coding product of Calca revealed a ...
Tópico(s): Muscle Physiology and Disorders
2020 - Hindawi Publishing Corporation | Stem Cells International
Zhe Zhang, Peng Zhong, Fei Hu, Zeke Barger, Ren Yu-lan, Xinlu Ding, Shangzhong Li, Franz Weber, Shinjae Chung, Richard D. Palmiter, Yang Dan,
... glutamatergic neurons expressing calcitonin gene-related peptide alpha (CALCA) are NREM-sleep active; optogenetic and chemogenetic activation/ ... strongly promote NREM sleep. Within the pIII region, CALCA neurons form reciprocal connections with another population of ... of CCK neurons also promoted NREM sleep. Both CALCA and CCK neurons project rostrally to the preoptic hypothalamus, whereas CALCA neurons also project caudally to the posterior ventromedial ...
Tópico(s): Vestibular and auditory disorders
2019 - Cell Press | Cell
Guoping Ma, Jing Yang, Bange Zhao, Chengquan Huang, Rui Wang,
... of the CCL2 gene rs4586 (g.5974T>C), CALCA rs3781719 (-692T>C), CX3CL1 rs614230 (2342C>T), and ... Han women.We analyzed the CCL2 gene rs4586, CALCA rs3781719, CX3CL1 rs614230 single nucleotide polymorphism (SNPs) of ... without chronic pain (HC). The levels of CCL2, CALCA, and CX3CL1 in serum were detected by enzyme- ... 336, 95% CI: 0.644-0.835). The CALCA gene rs3781719C allele was a risk factor for ... 1.424). CCL2 rs4586, CX3CL1 gene rs614230, and CALCA gene rs3781719 locus gene polymorphisms were associated with ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2019 - Wolters Kluwer | Medicine
T. John Martin, Natalie A. Sims,
... gene-related peptide (CGRP) gene resulted in mice (Calca-/-) that were much less able than wild type ... an explanation for the increased bone formation in Calca-/- mice, something that could never have been predicted. ... evident at age 3 months contrasts with the Calca-/- and Calcr-/- mice, at which time increased bone ... as early as age 1 month in the Calca-/- mice.13 Irrespective of this difference in timing, ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2015 - Oxford University Press | Journal of Bone and Mineral Research
Yuichi Toriyama, Yasuhiro Iesato, Akira Imai, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa‐Shindo, Hisaka Kawate, Akihiro Yamauchi, Kyoko Igarashi, Megumu Tanaka, Tian Liu, Xian Xian, Liuyu Zhai, Shinji Owa, Toshinori Murata, Takayuki Shindo,
Calcitonin gene–related peptide (CGRP; official name CALCA) has a variety of functions and exhibits both angiogenic and anti-inflammatory properties. We previously reported the angiogenic effects of the CGRP family ... inflammation. Calcitonin gene–related peptide (CGRP; official name CALCA) has a variety of functions and exhibits both ... myopia. Calcitonin gene–related peptide (CGRP; official symbol CALCA) is a 37–amino acid peptide produced by ... of the primary transcript of the calcitonin gene (CALCA). CGRP was originally identified as a sensory neurotransmitter, ...
Tópico(s): Chemokine receptors and signaling
2015 - Elsevier BV | American Journal Of Pathology
Max Daniel Kauther, Carl Neuerburg, Florian Wefelnberg, Hagen S. Bachmann, Rüdiger Schlepper, Gero Hilken, Martina Broecker‐Preuss, Florian Grabellus, Arndt F. Schilling, Markus Jäger, Christian Wedemeyer,
... α-CGRP (Calcitonin gene-related peptide)-deficient mice (Calca−/−) might modify our previous findings regarding CT/α- ... groups of twelve-month-old wild-type and Calca−/− mice underwent either SHAM surgery with and without ... There was no osteolysis in aged particle-treated Calca−/− animals and the effect of CT on PIO ... were significantly higher numbers of TRAP+ cells in Calca−/− animals, and bone remodeling markers revealed a significant ...
Tópico(s): Vitamin K Research Studies
2013 - Elsevier BV | Biomaterials