Thomas McAndrew, Maimuna S. Majumder, Andrew A. Lover, Srini Venkatramanan, Paolo Bocchini, Tamay Besiroglu, Allison Codi, David Braun, Gaia Dempsey, Sam Abbott, Sylvain Chevalier, Nikos I Bosse, Juan Cambeiro,
... 2020.09.21.20196725PubMed Google Scholar, 5McAndrew T Cambeiro J Besiroglu T Aggregating human judgment probabilistic predictions ... osf.io/7vrmyGoogle Scholar, 8McAndrew T Codi A Cambeiro et al."Chimeric forecasting: combining probabilistic predictions from ... months before the first vaccine approval.5McAndrew T Cambeiro J Besiroglu T Aggregating human judgment probabilistic predictions ... osf.io/7vrmyGoogle Scholar, 8McAndrew T Codi A Cambeiro et al."Chimeric forecasting: combining probabilistic predictions from ...
Tópico(s): Viral Infections and Outbreaks Research
2022 - Elsevier BV | The Lancet Digital Health
Luca Tagliaferri, Ashwini Budrukkar, Jacopo Lenkowicz, Mauricio Cambeiro, Francesco Bussu, José Luis Guinot, Guido Hildebrandt, Bengt Johansson, Jens E. Meyer, Peter Niehoff, Á. Rovirosa, Zoltán Takácsi‐Nagy, Luca Boldrini, N. Dinapoli, Vito Lanzotti, Andrea Damiani, Roberto Gatta, Bruno Fionda, Valentina Lancellotta, Tamer Soror, Rafael Martínez Monge, Vincenzo Valentini, György Kovács,
... 76982. APA Tagliaferri, L., Budrukkar, A., Lenkowicz, J., Cambeiro, M., Bussu, F., & Guinot, J. et al. (2018). ... Chicago Tagliaferri, Luca, Ashwini Budrukkar, Jacopo Lenkowicz, Mauricio Cambeiro, Francesco Bussu, Jose Luis Guinot, and Guido Hildebrandt ... 76982. Harvard Tagliaferri, L., Budrukkar, A., Lenkowicz, J., Cambeiro, M., Bussu, F., Guinot, J., Hildebrandt, G., Johansson, ... 76982. Vancouver Tagliaferri L, Budrukkar A, Lenkowicz J, Cambeiro M, Bussu F, Guinot J et al. ENT ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2018 - Termedia Publishing House | Journal of Contemporary Brachytherapy
V. Besada, J.M. Andrade, F. Schultze, J. Fumega, Bruno Cambeiro Cambeiro, J.J. González,
Concentrations of five trace metals (Cd, Hg, Pb, Cu and Zn) in wild mussels (Mytilus galloprovincialis) from the Galician and Gulf of Biscay areas in Spain were monitored from 2000 to 2004. A pool of mussel soft tissue was prepared using 50 or more individuals representing the available size range (35–60 mm) present at the sampling points (A Coruña, Pontevedra and Vigo–Galicia, NW of Spain—and Avilés, Bilbao and Santander–Gulf of Biscay). Metals were analysed by atomic absorption spectrometry, AAS, ( ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2008 - Elsevier BV | Journal of Marine Systems
Н. И. Ларионова, Jun Miyatake Ondozabal, Emily G. Smith, Xacobe C. Cambeiro,
A photocatalytic method for the α-selective hydroaminoalkylation of cinnamate esters has been developed. The reaction involves the regioselective addition of α-aminoalkyl radicals generated from aniline derivatives or aliphatic amines to the α-position of unsaturated esters. The scope of aromatic alkenes was extended to styrenes undergoing hydroaminoalkylation with anti-Markovnikov selectivity, which confirms the importance of the aromatic group at the β-position. Simple scale-up is demonstrated ...
Tópico(s): Sulfur-Based Synthesis Techniques
2021 - American Chemical Society | Organic Letters
Julien Rolland, Xacobe C. Cambeiro, Carles Rodríguez‐Escrich, Miquel À. Pericàs,
A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.
Tópico(s): Oxidative Organic Chemistry Reactions
2009 - Beilstein Institute for the Advancement of Chemical Sciences | Beilstein Journal of Organic Chemistry
Javier Cortés, J. Rodríguez, Juan A. Díaz-González, Carlos Garzón, Alfonso Gúrpide, Leire Arbea, Ignacio Gil‐Bazo, V. Navarro, Mauricio Cambeiro, A I Nicolas, Salvador Martín‐Algarra, Jesús García‐Foncillas, Emiliano Calvo,
Tumour response evaluation after chemotherapy has become crucial in the development of many drugs. In contrast to the standard bidimensional WHO criteria, the recently described Response Evaluation Criteria In Solid Tumors are based on unidimensional measurements. The aim of the present study was to compare both methods in patients with metastatic non-small cell lung cancer. One hundred and sixty-four patients treated with two cisplatin-paclitaxel-based chemotherapy schedules between June 1994 and ...
Tópico(s): Lung Cancer Research Studies
2002 - Springer Nature | British Journal of Cancer
... Raposeiras-Roubín S, García-Seara J, López X, Cambeiro C, Alcalde O, García-Bolao I, Martínez-Sande ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2002 - Lippincott Williams & Wilkins | Circulation
Javier Aristu, Rosa Cañón, Fernando Pardo, Rafael Martı́nez-Monge, Salvador Martín‐Algarra, José Manuel Ordóñez, E. Villafranca, Marta Moreno, Mauricio Cambeiro, Ignacio Azinovic,
Simultaneous chemoradiation is used in unresectable pancreatic cancer for palliation. It is not known if the use of adjuvant surgery will benefit this group of patients. From November 1991 to September 1998, 47 patients with unresectable pancreatic cancer were treated with simultaneous preoperative radiation therapy (45 Gy) and chemotherapy. Chemotherapy followed three different protocols: cisplatin, 5-fluorouracil ± paclitaxel; cisplatin, 5-fluorouracil (protracted infusion); and docetaxel and gemcitabine. ...
Tópico(s): Cancer Diagnosis and Treatment
2003 - Lippincott Williams & Wilkins | American Journal of Clinical Oncology
A. Gómez-Iturriaga, Luis Pina, Mauricio Cambeiro, Fernando Martínez-Regueira, José Manuel Aramendía, Óscar Fernández-Hidalgo, Rafael Martı́nez-Monge,
Purpose To evaluate the feasibility and intermediate-term results of conservative surgery, adjuvant chemotherapy, and delayed accelerated partial breast irradiation (APBI) with high-dose-rate brachytherapy. Methods and Materials Between 2000 and 2007, a total of 26 patients with a median age of 54 years were treated with conservative surgery followed by adjuvant chemotherapy and exclusive high-dose-rate brachytherapy. Inclusion criteria followed the Radiation Therapy Oncology Group 95-17 trial guidelines. ...
Tópico(s): Effects of Radiation Exposure
2008 - Elsevier BV | Brachytherapy
Rafael Martı́nez-Monge, A. Gómez-Iturriaga, Mauricio Cambeiro, Cristina Garrán, Néstor Montesdeoca, Javier Aristu, Juan Alcalde,
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2008 - Elsevier BV | Brachytherapy
Xacobe C. Cambeiro, Miquel À. Pericàs,
Abstract The preparation of 2‐triazolyl‐ and 2‐triazolylmethylpyrrolidines from L ‐proline and L ‐ trans ‐4‐hydroxyproline is described, along with their evaluation as chiral ligands in ruthenium‐catalyzed asymmetric transfer hydrogenation. Modular evolution of the ligands by introduction of remote substituents is also presented, showing a surprisingly important effect on the performance of the ligands.
Tópico(s): Cyclopropane Reaction Mechanisms
2010 - Wiley | Advanced Synthesis & Catalysis
Concepción Pérez-García, José M. Cambeiro, Paloma Morán, Juan J. Pasantes,
Abstract The chromosomes of the mussel Perumytilus purpuratus were analyzed by means of 4’,6-diamidino-2-phenylindole (DAPI)/propidium iodide (PI) and chromomycin A3 (CMA)/DAPI fluorescence staining and fluorescent in situ hybridization (FISH) with major rDNA, 5S rDNA, core histone gene and telomeric probes. The diploid chromosome number in this species is 32. The karyotype is composed by two metacentric, five submetacentric, one subtelo/submetacentric and eight subtelocentric chromosome pairs. The ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2010 - Elsevier BV | Journal of Experimental Marine Biology and Ecology
Esther Alza, Xacobe C. Cambeiro, Ciril Jimeno, Miquel À. Pericàs,
The development of a highly efficient, polymer-supported organocatalyst for the Michael addition of ketones to nitroolefins is described. A 1,2,3-triazole ring, constructed through a click 1,3-cycloaddition, plays the double role of grafting the chiral pyrrolidine monomer onto the polystyrene backbone and of providing a structural element, complementary to pyrrolidine, key to high catalytic activity and enantioselectivity. Optimal operation in water and full recyclability make the triazole linker ...
Tópico(s): Cyclopropane Reaction Mechanisms
2007 - American Chemical Society | Organic Letters
Marta Moreno, Javier Aristu, Luis Ramos, Leire Arbea, José M. López-Picazo, Mauricio Cambeiro, Rafael Martı́nez-Monge,
Tópico(s): Effects of Radiation Exposure
2007 - Springer Science+Business Media | Clinical & Translational Oncology
Rafael Martı́nez-Monge, M. Pagola Divassón, Mauricio Cambeiro, Miren Gaztañaga, Marta Moreno, Leire Arbea, Néstor Montesdeoca, Juan Alcalde,
To determine the impact of a set of patient, tumor, and treatment factors on toxicity and outcome in patients with head-and-neck squamous cell cancer treated with surgical resection and perioperative high-dose rate brachytherapy (PHDRB) alone (single-modality [SM] group) (n = 46) or PHDRB combined with postoperative radiation or chemoradiation (combined-modality [CM] group) (n = 57).From 2000 to 2008, 103 patients received PHDRB after complete macroscopic resection. SM patients received 32 or 40 Gy of PHDRB ...
Tópico(s): Ear and Head Tumors
2011 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Xacobe C. Cambeiro, Rafael Martín‐Rapún, Pedro O. Miranda, Sonia Sayalero, Esther Alza, Patricia Llanes, Miquel À. Pericàs,
The application of polystyrene-immobilized proline-based catalysts in packed-bed reactors for the continuous-flow, direct, enantioselective α-aminoxylation of aldehydes is described. The system allows the easy preparation of a series of β-aminoxy alcohols (after a reductive workup) with excellent optical purity and with an effective catalyst loading of ca. 2.5% (four-fold reduction compared to the batch process) working at residence times of ca . 5 min.
Tópico(s): Asymmetric Hydrogenation and Catalysis
2011 - Beilstein Institute for the Advancement of Chemical Sciences | Beilstein Journal of Organic Chemistry
I. San Miguel, Mikel San-Julián, Mauricio Cambeiro, Miguel F. Sanmamed, Blanca Vázquez-García, María Pagola, Miren Gaztañaga, Salvador Martín‐Algarra, Rafael Martı́nez-Monge,
The present study was undertaken to determine factors predictive of toxicity, patterns of failure, and survival in 60 adult patients with soft tissue sarcomas of the extremity and superficial trunk treated with combined perioperative high-dose-rate brachytherapy and external beam radiotherapy.The patients were treated with surgical resection and perioperative high-dose-rate brachytherapy (16 or 24 Gy) for negative and close/microscopically positive resection margins, respectively. External beam radiotherapy ( ...
Tópico(s): Vascular Tumors and Angiosarcomas
2011 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Leire Arbea, Rafael Martı́nez-Monge, Juan A. Díaz-González, Marta Moreno, Javier Rodríguez, José Luis Hernández-Davó, J. Solá, Luis Ramos, João Subtil, Jorge Núñez, Á. Chopitea, Mauricio Cambeiro, Miren Gaztañaga, Jesús García‐Foncillas, Javier Aristu,
Purpose To validate tolerance and pathological complete response rate (pCR) of a 4-week preoperative course of intensity-modulated radiation therapy (IMRT) with concurrent capecitabine and oxaliplatin (CAPOX) in patients with locally advanced rectal cancer. Methods and Materials Patients with T3 to T4 and/or N+ rectal cancer received preoperative IMRT (47.5 Gy in 19 fractions) with concurrent capecitabine (825 mg/m2 b.i.d., Monday to Friday) and oxaliplatin (60 mg/m2 on Days 1, 8, and 15). Surgery was ...
Tópico(s): Colorectal Cancer Treatments and Studies
2011 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Fermín Cambeiro, Susana López, Jesús A. Varela, Carlos Saá,
A novel tandem Ru-catalyzed carbene addition to terminal alkynes/insertion into CH bonds in alkynyl acetals, ethers, and amines has been accomplished under mild reaction conditions (see scheme; TMS=trimethylsilyl). This cascade provides an efficient approach to form complex spiro and fused bicyclic structures by 1,5- and 1,6-hydride shift/cyclization sequences from vinylcarbene Ru intermediates. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents ...
Tópico(s): Catalytic Alkyne Reactions
2011 - Wiley | Angewandte Chemie International Edition
Mihai Raducan, Carles Rodríguez‐Escrich, Xacobe C. Cambeiro, Eduardo C. Escudero‐Adán, Miquel À. Pericàs, Antonio M. Echavarren,
[Au(tmbn)2](SbF6) is the first gold(I) complex supported by two nitrile ligands that is indefinitely stable at room temperature. This is a highly versatile precatalyst that can be used for the preparation of active and robust solid-supported gold(I) catalysts.
Tópico(s): Catalysis for Biomass Conversion
2011 - Royal Society of Chemistry | Chemical Communications
Miquel À. Pericàs, Esther Alza, Sonia Sayalero, Xacobe C. Cambeiro, Rafael Martín‐Rapún, Pedro O. Miranda,
Diarylprolinol silyl ethers immobilized onto polystyrene have been employed as catalysts in the enantioselective domino Michael-Knoevenagel reaction of dimethyl 3-oxoglutarate and 3-substituted acrolein derivatives, including aliphatic ones. The best catalyst allows the preparation of highly functionalized cyclohexane derivatives in a straightforward and efficient manner, both under batch and continuous flow conditions.
Tópico(s): Analytical Chemistry and Chromatography
2011 - Thieme Medical Publishers (Germany) | Synlett
Verónica de la Fuente, Rocı́o Marcos, Xacobe C. Cambeiro, Sergio Castillón, Carmen Claver, Miquel À. Pericàs,
Abstract Phosphinoimidazoline (PHIM) ligands bearing a triazolylmethyl substituent at the sp 3 nitrogen atom in the imidazoline ring lead to highly improved enantioselectivity (up to 99% ee ) in allylic substitution reactions with respect to analogous ligands with substituents lacking the triazole unit. NMR and theoretical studies support a shift in the coordination mode of the PHIM ligand to palladium, triggered by a very favourable interaction with the triazole unit.
Tópico(s): Chemical Synthesis and Analysis
2011 - Wiley | Advanced Synthesis & Catalysis
Fermín Cambeiro, Susana López, Jesús A. Varela, Carlos Saá,
Ein neues Tandem: Eine Ru-katalysierte Carbenaddition an endständige Alkine und eine Insertion in die C-H-Bindungen von Alkinylacetalen, -ethern und -aminen unter milden Reaktionsbedingungen (siehe Schema; TMS=Trimethylsilyl) bietet einen effizienten Ansatz für die Bildung von komplexen Spiro- und anellierten bicyclischen Strukturen durch Sequenzen aus 1,5- und 1,6-Hydrid-Verschiebungen und Cyclisierungen von Vinylcarben-Ru-Zwischenstufen.
Tópico(s): Catalytic Cross-Coupling Reactions
2011 - Wiley | Angewandte Chemie
Rafael Martı́nez-Monge, Mauricio Cambeiro, Mikel San-Julián, Luis Sierrasesúmaga,
Brachytherapy is a sophisticated radiation method in which radioisotopes are placed inside or at a short distance from the tumour. The volume of tissue that receives the prescribed dose of radiotherapy is therefore fairly small compared with that used in standard radiotherapy techniques. In paediatric oncology, this method of radiation delivery can have a favourable effect on several undesirable long-term side-effects that sometimes develop in children who receive radiotherapy, such as growth retardation ...
Tópico(s): Glioma Diagnosis and Treatment
2006 - Elsevier BV | The Lancet Oncology
Rafael Martı́nez-Monge, Juan Alcalde, Carlos Concejo, Mauricio Cambeiro, Cristina Garrán,
This study was undertaken to determine the feasibility of salvage surgery and perioperative high-dose-rate brachytherapy (PHDRB) at the dose/fractionation schedule proposed in patients with previously irradiated, recurrent head and neck cancer or second primary tumors arising in a previously irradiated field.Twenty-five patients were treated with surgical resection and PHDRB. The PHDRB dose was 4 Gy b.i.d. x 8 (32 Gy) for R0 resections and 4 Gy b.i.d. x 10 (40 Gy) for R1 resections. Further external ...
Tópico(s): Head and Neck Surgical Oncology
2006 - Elsevier BV | Brachytherapy
Emad Abu‐Assi, Sergio Raposeiras‐Roubín, Pamela Lear, Pilar Cabanas‐Grandío, Mar Rodriguez Gírondo, Marta Rodríguez-Cordero, Eva Pereira-López, Santiago Gestal Romaní, Cristina González-Cambeiro, Belén Álvarez Álvarez, José Marı́a Garcı́a-Acuña, José Ramón González–Juanatey,
Haemorrhagic complications are strongly linked with adverse outcomes in acute coronary syndrome (ACS) patients. Various risk scores (RS) are available to predict bleeding risk in these patients. We compared the performance of three contemporary bleeding RS in ACS.We studied 4500 consecutive patients with ACS. We calculated the ACTION, CRUSADE, and Mehran et al. (2010) bleeding RS, and evaluated their performance for predicting their own major bleeding events and TIMI serious (major or minor) bleeding ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2012 - Oxford University Press | European Heart Journal Acute Cardiovascular Care
Rafael Martı́nez-Monge, Marta Moreno, R. Ciérvide, Mauricio Cambeiro, Jose Luis Pérez‐Gracia, Ignacio Gil‐Bazo, Miren Gaztañaga, Leire Arbea, Ignacio Pascual, Javier Aristu,
Purpose To determine the feasibility of combined long-term androgen deprivation therapy (ADT) and dose escalation with high-dose-rate (HDR) brachytherapy. Methods and Materials Between 2001 and 2007, 200 patients with high-risk prostate cancer (32.5%) or very high-risk prostate cancer (67.5%) were prospectively enrolled in this Phase II trial. Tumor characteristics included a median pretreatment prostate-specific antigen of 15.2 ng/mL, a clinical stage of T2c, and a Gleason score of 7. Treatment consisted ...
Tópico(s): Advanced Radiotherapy Techniques
2012 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Julián Bergueiro, Javier Montenegro, Fermín Cambeiro, Carlos Saá, Susana López,
Abstract This paper presents a full account of the use of Hiyama cross‐coupling reactions in a highly convergent approach to retinoids in which the key step is construction of the central C10C11 bond. Representatives of two families of oxygen‐activated dienyl silanes (ethoxysilanes and silanols) and of all reported families of “safety‐catch” silanols (siletanes, silyl hydrides, allyl‐, benzyl‐, aryl‐, 2‐pyridyl‐ and 2‐thienylsilanes) were regio‐ and stereoselectively prepared and stereospecifically ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2012 - Wiley | Chemistry - A European Journal
Xacobe C. Cambeiro, Tanya C. Boorman, Pengfei Lu, Igor Larrosa,
Gold bringt uns zusammen: Indem die orthogonale Reaktivität von AuI und AuIII bei der C-H-Aktivierung elektronenarmer bzw. -reicher Arene genutzt wurde, gelang ein neuer Zugang zu Biarylen durch doppelte C-H-Aktivierung. Stöchiometrische Studien belegen, dass diese oxidativen Kupplungen bei niedriger Temperatur mit hoher Selektivität ablaufen.
Tópico(s): Catalytic Cross-Coupling Reactions
2012 - Wiley | Angewandte Chemie
Sergio Raposeiras‐Roubín, Emad Abu-Assi, Pilar Cabanas‐Grandío, Rosa María Agra-Bermejo, Santiago Gestal-Romarí, Eva Pereira-López, Rubén Fandiño‐Vaquero, Belén Álvarez Álvarez, Cristina González Cambeiro, Marta Rodríguez-Cordero, Pamela Lear, Amparo Martínez‐Monzonís, Carlos Peña, José Marı́a Garcı́a-Acuña, José Ramón González–Juanatey,
This study sought to compare the in-hospital prognostic values of the original and updated GRACE (Global Registry of Acute Coronary Events) risk score (RS) and the AR-G (ACTION [Acute Coronary Treatment and Intervention Outcomes Network] Registry and the GWTG [Get With the Guidelines] Database) RS in acute coronary syndromes (ACS). To evaluate the utility of recalculating risk after percutaneous coronary intervention (PCI) with newer RS models (NCDR [National Cardiovascular Data Registry] and EHS [EuroHeart ...
Tópico(s): Cardiac Imaging and Diagnostics
2012 - Elsevier BV | КАРДИОЛОГИЯ УЗБЕКИСТАНА