Margarida Carrolo, Silvia Giordano, Laura Cabrita‐Santos, Simona Corso, Ana Margarida Vigário, Susana Silva, Patrícia Leirião, Daniel Carapau, Rosario Armas-Portela, Paolo M. Comoglio, Ana Rodrı́guez, Maria M. Mota,
Tópico(s): Cancer Mechanisms and Therapy
2003 - Nature Portfolio | Nature Medicine
Martine Pomérance, Daniel Carapau, Françoise Chantoux, Michaël Mockey, Claude Corrèze, Jacques Francon, Jean‐Paul Blondeau,
The cAMP pathway activates p38-MAPKs in the FRTL-5 rat thyroid cell line, contributing to the increased expression of the Na+/I- symporter (NIS) mRNA. This study investigates the cAMP-dependent expression and transcriptional activity of the p38-MAPK substrate CCAAT/enhancer-binding protein-homologous protein (CHOP). CHOP is expressed in the rat thyroid gland and in confluent PCCL3 and FRTL-5 cells. In FRTL-5 cells, TSH withdrawal induced a rapid down-regulation of CHOP that could be prevented by forskolin ( ...
Tópico(s): Redox biology and oxidative stress
2003 - Oxford University Press | Molecular Endocrinology
Produção Nacional
Revisado por pares
Sabrina Epiphânio, Marta Campos, Ana Pamplona, Daniel Carapau, Ana C. Pena, Ricardo Ataíde, Carla A. A. Monteiro, Nuno Damácio de Carvalho Félix, Artur Costa-Silva, Cláudio Romero Farias Marinho, Sérgio Dias, Maria M. Mota,
The spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of disease such as cerebral malaria (CM), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), pregnancy-associated malaria (PAM) or severe anemia (SA). Rodent models that mimic human CM, PAM and SA syndromes have been established. Here, we show that DBA/2 mice infected with P. berghei ANKA constitute a new model for malaria-associated ALI. ...
Tópico(s): Complement system in diseases
2010 - Public Library of Science | PLoS Pathogens
Esther Bettiol, Daniel Carapau, Cristina Galan-Rodriguez, Carlos Ocaña‐Morgner, Ana Rodrı́guez,
Abstract Background Infection with Plasmodium is the cause of malaria, a disease characterized by a high inflammatory response in the blood. Dendritic cells (DC) participate in both adaptive and innate immune responses, influencing the generation of inflammatory responses. DC can be activated through different receptors, which recognize specific molecules in microbes and induce the maturation of DC. Methods Using Plasmodium yoelii , a rodent malaria model, the effect of Plasmodium -infected erythrocytes ...
Tópico(s): Immune Cell Function and Interaction
2010 - BioMed Central | Malaria Journal
Miguel Prudêncio, Maria M. Mota,
... S. Vigario A.M. Silva S. Leiriao P. Carapau D. Armas-Portela R. Comoglio P.M. et ...
Tópico(s): Toxoplasma gondii Research Studies
2007 - Cell Press | Cell Host & Microbe
Daniel Carapau, Mogens Kruhofer, Allison Chatalbash, Jamie Orengo, Maria M. Mota, Ana Rodrı́guez,
Dendritic cells (DCs) have been proposed as mediators of immunity against malaria parasites, as well as a target for inhibition of cellular responses. Here we describe the transcriptomic analysis of spleen DCs in response to Plasmodium infection in a rodent model. We identified a high number of unique transcripts modulated in DCs upon infection. Many cellular functions suffer extensive genomic regulation including the cell cycle, the glycolysis and purine metabolism pathways and also defence responses. ...
Tópico(s): vaccines and immunoinformatics approaches
2007 - Wiley | Cellular Microbiology
Rosangela Frita, Daniel Carapau, Maria M. Mota, Thomas Hänscheid,
Hemozoin (Hz) is released into the blood stream after rupture of infected red blood cells (iRBCs) at the end of each parasite replication cycle. This free Hz is ingested by circulating and resident phagocytes. The presence of Hz in tissues after clearance of infection has been previously reported. Still, little is known about the kinetics of Hz in vivo , during and after Plasmodium infection. It is particularly important to understand Hz kinetics after malaria infections as it has been reported that ...
Tópico(s): Hemoglobinopathies and Related Disorders
2012 - Hindawi Publishing Corporation | Malaria Research and Treatment
Craig T. Przysiecki, Bob J. Lucas, Robert A. Mitchell, Daniel Carapau, Zhiyun Wen, Hui Xu, Xinmin Wang, Debbie Nahas, Chengwei Wu, Robert W. Hepler, Elizabeth A. Ottinger, Jan ter Meulen, David C. Kaslow, John W. Shiver, Elizabeth Nardin,
Antibodies that neutralize infectivity of malaria sporozoites target the central repeat region of the circumsporozoite (CS) protein, which in Plasmodium falciparum is comprised primarily of 30-40 tandem NANP tetramer repeats. We evaluated immunogenicity of an alum-adsorbed (NANP)6 peptide conjugated to an outer membrane protein complex (OMPC) derived from Neisseria meningitidis, a carrier protein used in a licensed H. influenzae pediatric vaccine. Mice immunized with alum-adsorbed (NANP)6-OMPC, with ...
Tópico(s): Parasites and Host Interactions
2012 - Frontiers Media | Frontiers in Cellular and Infection Microbiology
Daniel Carapau, Robert A. Mitchell, Adéla Nacer, Alan Shaw, Caroline Othoro, Ute Frevert, Elizabeth Nardin,
Immunization with Plasmodium sporozoites can elicit high levels of sterile immunity, and neutralizing antibodies from protected hosts are known to target the repeat region of the circumsporozoite (CS) protein on the parasite surface. CS-based subunit vaccines have been hampered by suboptimal immunogenicity and the requirement for strong adjuvants to elicit effective humoral immunity. Pathogen-associated molecular patterns (PAMPs) that signal through Toll-like receptors (TLRs) can function as potent ...
Tópico(s): Mosquito-borne diseases and control
2013 - American Society for Microbiology | Infection and Immunity
Adéla Nacer, Daniel Carapau, Robert A. Mitchell, A. Meltzer, Alan Shaw, Ute Frevert, Elizabeth Nardin,
Intranasal (IN) immunization with a Plasmodium circumsporozoite (CS) protein conjugated to flagellin, a Toll-like receptor 5 agonist, was found to elicit antibody-mediated protective immunity in our previous murine studies. To better understand IN-elicited immune responses, we examined the nasopharynx-associated lymphoid tissue (NALT) in immunized mice and the interaction of flagellin-modified CS with murine dendritic cells (DCs) in vitro. NALT of immunized mice contained a predominance of germinal ...
Tópico(s): Malaria Research and Control
2013 - Elsevier BV | Mucosal Immunology
Peter Liehl, Vanessa Zuzarte‐Luís, Jennie Chan, Thomas Zillinger, Fernanda G. Baptista, Daniel Carapau, Madlen Konert, Kirsten K. Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Ângelo Ferreira Chora, Douglas T. Golenbock, Birgit Strobl, Miguel Prudêncio, Luís Pedro Coelho, Stefan H. I. Kappe, Giulio Superti‐Furga, Andreas Pichlmair, Ana Margarida Vigário, Charles M. Rice, Katherine A. Fitzgerald, Winfried Barchet, Maria M. Mota,
After mosquito bite, the malaria parasite first infects the liver, where it is thought to be undetected by the host immune system as it develops into the blood-stage pathogen. Maria Mota and her colleagues now report that Plasmodium RNA is detected by hepatocytes, triggering an interferon response that controls the parasite burden in the liver and blood of infected mice. Before they infect red blood cells and cause malaria, Plasmodium parasites undergo an obligate and clinically silent expansion ...
Tópico(s): Malaria Research and Control
2013 - Nature Portfolio | Nature Medicine
Debashree Goswami, Nana Minkah, Stefan H.I. Kappe,
... Luís V. Chan J. Zillinger T. Baptista F. Carapau D. et al.Host-cell sensors for Plasmodium ...
Tópico(s): Hepatitis B Virus Studies
2021 - Elsevier BV | Journal of Hepatology
João Serrano, Shakib Shahidian, Ângelo Carapau, Ana Elisa Rato,
Dryland pastures provide the basis for animal sustenance in extensive production systems in Iberian Peninsula. These systems have temporal and spatial variability of pasture quality resulting from the diversity of soil fertility and pasture floristic composition, the interaction with trees, animal grazing, and a Mediterranean climate characterized by accentuated seasonality and interannual irregularity. Grazing management decisions are dependent on assessing pasture availability and quality. Conventional ...
Tópico(s): Ruminant Nutrition and Digestive Physiology
2021 - Multidisciplinary Digital Publishing Institute | AgriEngineering
Esther Bettiol, Diana L. van de Hoef, Daniel Carapau, Ana Rodrı́guez,
Dendritic cells (DC) and macrophages phagocytose pathogens and degrade them in their phagosomes to allow for proper presentation of foreign antigens to other cells of the immune system. The Plasmodium parasite, causative agent of malaria, infects RBC that are phagocytosed by DC and macrophages during the course of infection. Under specific conditions, the functionality of these cells can be affected by phagocytosis of Plasmodium-infected RBC. We investigated whether phagosomal maturation and degradation ...
Tópico(s): Immunotherapy and Immune Responses
2010 - Wiley | Parasite Immunology
Fernando Carapau, Paulo Correia,
Tópico(s): Nanofluid Flow and Heat Transfer
2017 - Elsevier BV | European Journal of Mechanics - B/Fluids
Fernando Carapau, Adélia Sequeira,
The aim of this paper is to analyze the axisymmetric unsteady flow of a nonNewtonian incompressible second order fluid in a straight rigid and impermeable tube with circular cross-section of constant radius. To study this problem, we use the one dimensional (1D) nine-directors Cosserat theory approach which reduces the exact three-dimensional equations to a system depending only on time and on a single spatial variable. From this system we obtain the relationship between mean pressure gradient and ...
Tópico(s): Fluid Dynamics and Vibration Analysis
2006 - WIT Press | WIT transactions on engineering sciences
We study the unsteady motion of a viscoelastic fluid modeled by a second-order fluid where normal stress coefficients and viscosity depend on the shear rate by using a power-law model. To study this problem, we use the one-dimensional nine-director Cosserat theory approach which reduces the exact three-dimensional equations to a system depending only on time and on a single spatial variable. Integrating the equation of conservation of linear momentum over the tube cross-section, with the velocity ...
Tópico(s): Phase Equilibria and Thermodynamics
2010 - Elsevier BV | Nonlinear Analysis Real World Applications
Fernando Carapau, Adélia Sequeira,
The aim of this paper is to analyze the axisymmetric unsteady flow of a non-Newtonian incompressible second order fluid in a straight rigid and impermeable tube with circular cross-section of constant radius.To study this problem, we use the one dimensional (1D) nine-directors Cosserat theory approach which reduces the exact three-dimensional equations to a system depending only on time and on a single spatial variable.From this system we obtain the relationship between mean pressure gradient and ...
Tópico(s): Nonlocal and gradient elasticity in micro/nano structures
2006 - WIT Press | WIT transactions on engineering sciences
Fernando Carapau, João Janela,
A one-dimensional model for the flow of a viscous fluid with axisymmetric swirling motion is derived in the particular case of a straight tube of variable circular cross-section. The model is obtained by integrating the Navier–Stokes equations over cross section the tube, taking a velocity field approximation provided by the Cosserat theory. This procedure yields a one-dimensional system, depending only on time and a single spatial variable. The velocity field approximation satisfies exactly both ...
Tópico(s): Rheology and Fluid Dynamics Studies
2013 - Elsevier BV | International Journal of Engineering Science
Fernando Carapau, Paulo Correia, Luís M. Grilo,
A specific modified constitutive equation for a third-grade fluid is proposed so that the model be suitable for applications where shear-thinning or shear-thickening may occur. For that, we use the Cosserat theory approach reducing the exact three-dimensional equations to a system depending only on time and on a single spatial variable. This one-dimensional system is obtained by integrating the linear momentum equation over the cross-section of the tube, taking a velocity field approximation provided ...
Tópico(s): Fluid Dynamics and Turbulent Flows
2016 - American Institute of Physics | AIP conference proceedings
Produção Nacional
Revisado por pares
Angelus Giuseppe Pereira da Silva, Clodomiro Alves,
1998 - Associação Brasileira de Cerâmica | Cerâmica
P. Areias, Carlos Tiago, J. Carrilho Lopes, Fernando Carapau, Paulo Correia,
Tópico(s): Numerical methods in engineering
2019 - Elsevier BV | European Journal of Mechanics - A/Solids
A. M. Simões, Fernando Carapau, Paulo Correia,
In this work, we present sufficient conditions in order to establish different types of Ulam stabilities for a class of higher order integro-differential equations. In particular, we consider a new kind of stability, the σ-semi-Hyers-Ulam stability, which is in some sense between the Hyers–Ulam and the Hyers–Ulam–Rassias stabilities. These new sufficient conditions result from the application of the Banach Fixed Point Theorem, and by applying a specific generalization of the Bielecki metric.
Tópico(s): Numerical methods for differential equations
2021 - Multidisciplinary Digital Publishing Institute | Symmetry
P. Areias, Rui Melício, Fernando Carapau, J. Carrilho Lopes,
A finite strain gradient model for the 3D analysis of materials containing spherical voids is presented. A two-scale approach is proposed: a least-squares methodology for RVE analysis with quadratic displacements and a full high-order continuum with both fourth-order and sixth-order elasticity tensors. A meshless method is adopted using radial basis function interpolation with polynomial enrichment. Both the first and second derivatives of the resulting shape functions are described in detail. Complete ...
Tópico(s): Composite Material Mechanics
2022 - Multidisciplinary Digital Publishing Institute | Mathematics
The aim of this paper, is to analyze the axisymmetric unsteady flow of an incompressible second order fluid in a slender body of revolution with circular cross section with variable radius. To make that, we use the Cosserat theory (also called director theory) related with the fluid dynamics which reduces the exact three-dimensional equations to a system which depends only on a single spatial and time variables. From this 1D system, we obtain for a flow in a rigid and impermeable tube, without swirling ...
Tópico(s): Elasticity and Material Modeling
2010 - Centre for Environment Social and Economic Research | International Journal of Applied Mathematics & Statistics/International journal of applied mathematics and statistics
Fernando Carapau, Pedro Pezarat‐Correia, Timon Rabczuk, P. Areias,
Tópico(s): Elasticity and Material Modeling
2020 - Springer Science+Business Media | Neural Computing and Applications
Hui-Shan Li, Shin Min-Kyoung, Bijay Singh, Yoo HanSang, Marharjan Sushila, Park Tae-Eun, Kang Sang-Kee, Zhong-Shan Hong, Yun‐Jaie Choi, Chong‐Su Cho,
... ileum, Biomaterials, 59 (2015) 144-159.[3] D. Carapau, R. Mitchell, A. Nacer, A. Shaw, C. Othoro, ...
Tópico(s): Pediatric health and respiratory diseases
2016 - Frontiers Media | Frontiers in Bioengineering and Biotechnology
Produção Nacional
Revisado por pares
Nayana da Silva Cordeiro, Maíra Moraes, Jean Carlos Miranda,
... o que reflete na diminuição de cavalinha, xerelete/carapau e galo, que fazem parte de sua fauna ...
Tópico(s): Aquaculture Nutrition and Growth
2019 - Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências | Research Society and Development
P. Areias, Timon Rabczuk, Fernando Carapau, J. Carrilho Lopes,
Tópico(s): Elasticity and Material Modeling
2019 - Elsevier BV | Finite Elements in Analysis and Design
Catarina Neves, Ana Leal, Lídia Santos, Luís Miguel Amaral Rodrigues, Carmen Do Carmo Carapau Ferreira, C Ferreira, Catarina Romãozinho, Arnaldo José De Castro Figueiredo,
Tópico(s): Organ Transplantation Techniques and Outcomes
2023 - Elsevier BV | Transplantation Proceedings