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Artigo Acesso aberto Revisado por pares

Yoshie Takaki, Tatsushi Muta, Sadaaki Iwanaga,

... saline. The specimen was mounted in Entellan neu (Merck) and viewed with a Carl Zeiss LSM 410 confocal laser scanning microscope. Anti- ...

Tópico(s): Peptidase Inhibition and Analysis

1997 - Elsevier BV | Journal of Biological Chemistry

Artigo

Angelika‐Maria Schadewinkel‐Scherkl, Folke Rasmussen, Carl‐Christian Merck, Poul Nielsen, Hans‐Hasso Frey,

Passage of benzylpenicillin across the mammary gland epithelium was studied both after systemic administration of benzylpenicillin in four goats and after intramammary infusion in three goats and two cows. The results after benzylpenicillin administration alone were compared with the results after combined administration of benzylpenicillin and probenecid. The studies on passage of benzylpenicillin through the blood‐milk barrier showed, when milk to plasma ultrafiltrate ratios of benzylpenicillin ...

Tópico(s): Antibiotic Resistance in Bacteria

1993 - Wiley | Pharmacology & Toxicology

Artigo Acesso aberto Revisado por pares

Michael J. Wynne,

A number of original watercolored illustrations of North Pacific marine algae accompanied by the original algal specimens are deposited in the State Botanical Collection, National Herbarium of Victoria, Australia. These illustrations were executed by W.G. Tilesius, surgeon-naturalist-artist on the Krusenstern Expedition (1803–06). One of these illustrated specimens was collected in the period 1790–91 on Unalaska Island, the Aleutian Islands, by C.H. Merck, naturalist-botanical collector on the Billings ...

Tópico(s): Cephalopods and Marine Biology

2009 - Arctic Institute of North America | ARCTIC

Jornais Acesso aberto

Dr. Josef Maria Eder, Prof. D. R. Abegg, Professor Hermann Krone, Dr. C. Kassner, Dr. V. Von Cordier, Dr. Otto Buss, Dr. Phil. Richard Jacoby, Hans Pabst, E. Pringsheim, O. Gradenwitz, Dr. Jaroslav Husnik, Ludwig Tschörner, Professor A. Albert, Dr. Georg Hauberrisser, Emil Bühler, Dr. M. Von Rohr, Dr. Med. Lischke, Dr. Hugo Krüss, Dr. Kurz'schen Fabrik, Dr. H. Harting, P. Baltin, Regierungsrath Georg Fritz, Dr. R. Neuhauss, Gebr. Lumière, Professor E. Valenta, Dr. Egon Müller, Dr. G. Krebs, Dr. G. Aarland, Ritter Von Staudenheim, B. Wanach, Hans Pabst, Professor Rodolfo Namias, Professor Rodolfo Namias, Professor Rodolfo Namias, Professor Rodolfo Namias, Professor Rodolfo Namias, Professor Rodolfo Namias, C. H. Bothamley, A. Albert, A. Von Obermayer, J. M. Eder, Professor Jak. Husnik, Raimund Rapp, E. Wallon, H. Kessler, Professor A. Albert, Hermann Schnauss, Dr. M. Andresen, Franz Novak, Eduard Kuchinka, K. Kampmann, Dr. Karl Schaum, Albert Hofmann, Arth. Wilh. Unger, Franz Fehr, Professor F. Schiffner, Gottlieb Marktanner-Turneretscher, Dr. Max Levy, E. Doležal, Henry O. Klein, Hugo Hinterberger, Johannes Gaedicke, Professor K. Kruis, R. Schüttauf, Dr. Leopold Freund, E. Doležal, Wilhelm Urban,

... Obernetter=Silbereosinplatten, E. Suter, Weisenbach Riffarth & Co., E. Merck, Gust. Schaenffelen' Sche Papierfabrik, Schwerter Papiere, Kodak Limited, Chemische Fabrik Auf Actien, Carl Seib, Ferdinand Flinsch, R. Lechner, Rathenower Optische Industrie- ...

1901 - Gale Group | NCCO Photography

Artigo Acesso aberto Revisado por pares

Michael K. Yoon, Royce W. S. Chen, Thomas R. Hedges, Vivek J. Srinivasan, Iwona Gorczyńska, James G. Fujimoto, Maciej Wojtkowski, Joel S. Schuman, Jay S. Duker,

... lecture fees from Alcon Laboratories, Inc., Allergan, Inc., Carl Zeiss Meditec, Merck U.S. Human Health, the National Eye Institute, ...

Tópico(s): Retinal and Macular Surgery

2007 - | Ophthalmic surgery, lasers & imaging retina

Artigo Acesso aberto Revisado por pares

Gerhard Liebisch, Silke Matysik,

... absolute EMSURE, and isopropanol LiChrosolv were purchased from Merck (Darmstadt, Germany). Chloroform ROTISOLV® was purchased from Carl Roth GmbH (Karlsruhe, Germany), and methanol LC-MS ...

Tópico(s): Pharmacological Effects and Toxicity Studies

2015 - Elsevier BV | Journal of Lipid Research

Jornais Acesso aberto

... Moll in Wien, R. Lechners, Multiple Display Advertisements, Carl Zeiss, Optische Werkstätte, Jena, Anzeigen I, E. Merck, Chemische Fabrik, Eiweiss-Lasurfarben, Retouchen Und Uebermalungen, Detectiv- ...

1895 - Gale Group | NCCO Photography

Carta Revisado por pares

Samantha Sii, Giacinto Triolo, Keith Barton,

... Allergan, Thea, Alcon, EyeTechCare; advisory boards—Glaukos, Alcon, Merck, Kowa, Amakem, Thea, Refocus, Ivantis; consultancy—Alcon, Aquesys, Ivantis, Carl Zeiss Meditec, Kowa, Santen, Transcend Medical.

Tópico(s): Retinal Diseases and Treatments

2018 - Wiley | Clinical and Experimental Ophthalmology

Jornais Acesso aberto

H. G. Baxton, D. F. Roche, George Barlow, Geo. M. Beard, Carl Seiler, Bushrod W. James, E. Merck,

Classified ads: The American Medical Journal, A. A. Constantine's Persian Healing Pine Tar Soap, Milk of Magnesia. Frontmatter: The Massachusetts Medical ...

1889 - Gale Group | NCCO-STM 1of2

Artigo Acesso aberto Revisado por pares

Cinzia Antognelli, Francesca Mancuso, Roberta Frosini, Iva Arato, Mario Calvitti, Riccardo Calafiore, Vincenzo Nicola Talesa, Giovanni Luca,

... Sigma-Aldrich, St. Louis, MO); FSH (GONAL-f; Merck Serono, Rome, Italy); Laemmli buffer (Invitrogen, Milan, Italy); Roti-Block (Carl Roth, Karsruhe, Germany); BCA Assay kit (Pierce; Thermo ...

Tópico(s): Advanced Glycation End Products research

2018 - Elsevier BV | American Journal Of Pathology

Jornais Acesso aberto

J. Gaedicke, K. K. Regierungsrath George Fritz, A. Albert, C. P. Goerz, A. Reichwein, Gebr. Lumière, Gebr. Lumière, J. Sterry, Chapman Jones, Eduard Kuchinka, Eduard Cerauke, Hofrath O. Volkmer, Dr. C. Grebe, J. M. Eder, E. Valenta, Raimund Rapp, C. Kampmann, Dr. Eugen Englisch, Dr. M. Von Rohr, J. M. Eder, Professor Hermann Krone, Professor E. Valenta, Dr. Adolf Hesekiel, A. V. Obermayer, R. Ed. Liesegang, C. H. Bothamley, Heinrich Biltz, Dr. K. Schwarzschild, A. W. Unger, Dr. R. Neuhauss, L. Belitski, Dr. Leopold Freund, Dr. Georg Hauberrisser, Dr. Friedrich Bidschof, Adolf Herzka, Dr. J. Hartmann, H. Hinterberger, Dr. G. Eberhard, Dr. Victor Cordier Von Löwenhaupt, Aug. Leutner, Josef Beck, J. Elster, Dr. Anton Elschnig, Chr. Harbers, L. Schrank, W. De W. Abney, Wilhelm Mayer, Richard Grossl, Dr. C. Kassner, Prof. F. Schiffner, Gottlieb Marktanner-Turneretscher, W. J. Russell, F. H. Glew, E. Doležal, E. Doležal, Gebrüder Lumière, Albert Hofmann, Henry O. Klein, W. Urban, H. Ehrenfeld, W. Gebauer, K. Hazura, Professor H. Miethe, Wilhelm Knapp,

... Engel-Feitknecht & Co., "Loki", Velox=Papier, Photographische Rundschau, Carl Zeiss, Rud. Schuster Photographisches Atelier, Handbuch Der Lithographie Und Des Steindruckes, E. A. Just & Cie, J. G. Schelter Giesecke, L. Angerer, Merck's Chemikalien Für Photographische Zwecke, R. Lechner (Wilhelm ...

1900 - Gale Group | NCCO Photography

Artigo Acesso aberto Revisado por pares

Jörg Koglin, Troels Glysing-Jensen, John S. Mudgett, Mary E. Russell,

... by Jeffrey R. Weidner and Richard A. Mumford (Merck Research Laboratories, Rahway, NJ) and kindly provided to us by Carl Nathan.14Xie QW Cho HJ Calaycay J Mumford ...

Tópico(s): Cell Adhesion Molecules Research

1998 - Elsevier BV | American Journal Of Pathology

Artigo Acesso aberto Revisado por pares

Maximilian Gassenmaier, Maximilian Rentschler, Birgit Fehrenbacher, Thomas Eigentler, Kristian Ikenberg, Corinna Kosnopfel, Tobias Sinnberg, Heike Niessner, Hans Bösmüller, Nikolaus B. Wagner, Martin Schaller, Claus Garbe, Martin Röcken,

... DAPI (1:2000; catalog number D9542; Sigma-Aldrich/Merck). Immunofluorescence images were obtained with a confocal laser scanning microscope (LSM 800; Carl Zeiss, Jena, Germany), and images were processed and ...

Tópico(s): Genomics and Chromatin Dynamics

2020 - Elsevier BV | American Journal Of Pathology

Jornais Acesso aberto

J. Madison Taylor, Prof. Dr. Carl Von Noorden, E. E. Montgomery, James K. Young, Geo. O. Jarvis, W. J. Hadley,

Frontmatter: International Medical Magazine. Table of contents: Original Papers. Display ads: Multiple Display Advertisements. Essay: Practical Notes ...

1902 - Gale Group | NCCO-STM 1of2

Artigo Acesso aberto Revisado por pares

Ana Stevanović, Christoph Thiele,

... water, coverslips were mounted in Mowiol 4-88 (Merck; Darmstadt, Germany) containing 2.5% DABCO (1,4-diazabicyclo[2.2.2]octane) (Carl Roth; Karlsruhe, Germany). Images were acquired with a ...

Tópico(s): Photosynthetic Processes and Mechanisms

2012 - Elsevier BV | Journal of Lipid Research

Jornais Acesso aberto

Eli H. Long, Roland O. Meisenbach, Joseph Burke, Robt. J. Talbot, Paul G. Weston, Wm. J. Dornan, Arthur Robinson, Frederick R. Bailey, E. Merck, H. A. Hare, L. F. Appleman, Edgar G. Ballenger, Omar F. Elder, Edgar Paullin, Donald Core,

... with Tuberculosis Hospital, Deaths in Professional Offices, E. Merck's Annual Report of Recent Advances in Pharmaceutical ... and Therapeutics. Vol. 26, 1912; Published by E. Merck. Darmstadt, Practice of Medicine. James Tyson, M.D., ...

1914 - Gale Group | NCCO-STM 1of2

Artigo Revisado por pares

T. Ottinger, Birgitta Rasmusson, Carl Hård af Segerstad, Melinda D. Merck, F. V. D. Goot, Lena Olsén, D. Gavier‐Widén,

To investigate the current status of forensic veterinary pathology, a survey was composed directed at pathology laboratories and institutes, mostly in Europe. The questions included number of and type of cases, resources available, level of special training of the investigating pathologists and the general view on the current status and future of the discipline. The surveys were sent to 134 laboratories and were returned by 72 respondents of which 93 per cent work on forensic pathology cases. The ...

Tópico(s): Human-Animal Interaction Studies

2014 - Wiley | Veterinary Record

Jornais Acesso aberto

Alan Nicholls, Frenderic Raphael, Kevin Dunn, Jonathan Northcroft, P B, John Dugdale, Matthew Wall, Barbara Hall, Lucas Hollweg, R Barber, Jeff Dawson, Gail Emms, Pippa Funnell, N J, Fred Redwood, Jim Munro, Andrew Bell, Helen Davies, Sally Brock, Rob Hughes, Jason Dawe, John Peter, Gideon Garter, Hamish Stevenson, Natalie Ayres, Nigel Bumham, David Wilson, Andrew Longmore, Adam Hathaway, Michael Littlewood, Susan d'Arcy, Gareth Walsh, Frank Whitford, Ivo Tennant, Matthew Davis, Terence Blacker, Caroline Brannigan, Nigel Planer, Kathryn Cooper, P D, Lucy Hughes-Hallett, David Smith, Paul Driver, Neil Wormald, E P, Andrew Sullivan, Clive Davis, Stephen Grey, K R, Andrew Porter, A C, Tony Allen-Mills, Simon Wilde, John O'Brien, D C, Martin James, Tom Walker, Anthony Sattin, Robert Winnett, Claire Harvey, Irwin Stelzer, Adrian Furnham, Robert Hewison, Peter Wilson, Rosie Millard, Stephen Wares, Michel, David Dougill, David Balddiel, Rob Hadgraft, Bob Thompson, Tony Marcus, A Limbert, R Pope, Geraldine Hackett, Richard Clarke, Sue Townsend, Rob Maul, David Hewson, Alistair Weaver, Xavier Rivoire, Paul French, Nigel Deacon, Hugh Canning, Geraldine Hackett Education Correspondent, Andrew Stone, Jeremy Clarkson, Edward Porter, Phil Spencer, Peter Conradi, Victoria Segal, David Cairns, Michael Portillo, Professor Tom Elliott, Stewart Lee, Peter Kemp, Anthony Peregrine, Tara Calishain, Sarah Dempster, Robert Harris, Dave Pollard, Robert Pires, Richard Fletcher, Bob Dylan, Liz Edwards, Gary Fiddes, Peter Oliver, George Perry, Jeremy Guscott, Jonathan Margolis, Colin Miller, John Padgett, Mike Laws, Peter Browm, Paul Ham, Christopher Silvester, Sarah-Kate Templeton, Roger Eglin, D MaCintyre, Paul Donovan, Dr Chris Allen, Mark Espiner, Tom Stubbs, Simon Mills, Chris Woodhead, David Powis, Jasper Gerard, Will Greenwood, Phil Craigic, Emma Thompson, Ann McFerran, Michael Barrows, Nicholas Hellen, Richard Brooks, John Follain, Garth Pearce, Ian Hawkey, Charles Saunders, Julian Corlett, Christopher Morgan, David Leppard, Alex Clark, Paul Durman, Paul Freestone, Milton Jones, Shelley Von Strunckel, Alicia Wyllie, Mark Edwards, Rachel Bridge, Hugh McLlvanney, Stephen Clarke, Kira Cochrane, Norman Sherry, Harriet Perry, Blower, James Brown, Sarah Turner, Achmat Dangor, Jonathan Cook, Christina Lamb, Stephanie Donworth, Michael Palin, Kathy Arnold, S M, Alan Combes, Sean Newsom, Ashlee Simpson, Raymond Keene, Michael Fraser, Cosmo Laandesman, C L, Eva Gronbech, Rod Liddle, Clive Rcuse, Penelope Lively, David Cracknell, Cosmo Landesman, Katrina Manson, Zoe Brennan, Tim Bowler, S B, Dominic O'Connell, Pat Coates, Peter Koenig, Richard Evans, Nick Cain, Louise Armitstead, Stephen Bleach, Adrienne Connors, Natalie Graham, Catherine Wheatley, David Davis, Caroline Donald, Alwyn Collister, Hugh McManners, Fiona Terry, Miranda Seymour, David Walsh, Caroline Gascoigne, Liat Joshi, Jack Grimston, Colin McDowell, Bryan Appleyard, Sarah Keenlyside, Stephen Armstrong, John Elliott, Donovan Winter, Mark Macaskill, Mark Anstead, Nathan Fletcher, Victoria O'brien, N R, Richard Woods, Roland White, Paul Wade, Shane Watson, Abul Taher, Maurice Chittenden, Dr Henry Gyasi, Richard Rae, Mark Franchetti, Joanna Jepson, Ray Hutton, Robert Bottamley, John Neal, Jonathan Leake, Sir Andrew Turnbull Cabinet Secretary and Head of the Home Civil Service, M E, John Crossland, Amanda Craig, Clare Francis, John Harlow, Dileep Premachandran, Yoko Ono, Dipesh Gadher, Michael Collins, Stephen Briggs, John Waples, Conrad Black, A A Gill, Denis Walsh, Matthew Campbell, Lucy West, Brian Highley, David James, Mary Braid, Lois Wilson, Stephen Pettitt, Will Iredale, Karen MacGregor, Jeremy Langmead, T L, Sally Kinnes, Judith Summers, Naomi Caine, Nigel Powell, Daniel Emery, Tony Robinson, Ben Dowell, Minette Marrin, John Aizlewood, Simon Buckland, Mark Hodson, Andrew Frankel, Graham Norwood, Clifford Bishop, Joe Lovejoy, Jonathan Futrell, J P, David Budworth, Bashir Maan, William Lewis Business editor, Andrew Davidson, Patrick Nolan, Hugh Pearman, Dan Cairns, Julian Gray, Stewart Mitchell, David Smith Economics Editor, Rachel De Thame, Penny Perrick, Sarah Baxter, James Willoughby, Matthew Goodman, India Knight, Simon Howard, Nina Goswami, Tom Bower, Barry Newcombe, Nick Faldo, Dominic Rushe, Ben West, Sian Griffiths, Karen Robinson, Adrienne Connore,

... Sunday Times No pain relief in sight as Merck withdraws Vioxx Merck used to be the most admired orugs ground ... Johnson HarperCollins £17.99 pp326 The Folio Society Carl Hiaasen Fabulously evil Thirteen Steps down by Ruth ...

2004 - Gale Group | Sunday Times HA GDA

Artigo Revisado por pares

Chu‐Biao Xue, Xiaohua He, John Roderick, William F. DeGrado, Robert J. Cherney, Karl D. Hardman, David J. Nelson, Robert A. Copeland, Bruce Jaffee, Carl P. Decicco,

... Nelson, Robert A. Copeland, Bruce D. Jaffee, and Carl P. DeciccoView Author Information The DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington, Delaware 19880-0500 ...

Tópico(s): Signaling Pathways in Disease

1998 - American Chemical Society | Journal of Medicinal Chemistry

Jornais Acesso aberto

Giles Smith, Andrew Robson, Gabriele Marcotti, David Wighton, Sir Fred Goodwin, D. S. Hoskins, David Brown, Alexandra Frean, Gary Duncan, Peter Lansley, Brian Smith, David Wilson, Paul Bompard, Robert Lindsay, Linda Tsang, Jamie Peacock, Catherine Boyle, Michael Evans Defence Editor, Philip Howard, Alison MacRae, David Chater, James Ducker, Andy Hayman, Clive Davis, Jeevan Deol, Patrick Kidd, Will Pavia, Wendy Ide, Jeremy Whittle, Kevin Eason, Peter Thickpenny, Geoff Brown, Martin Samuel Chief Football Correspondent, Sam Banik, Alan Collins, Martin Fletcher, Ben Webster Transport Correspondent, Francis Elliott, Jamie Stevenson, Dominic Walsh, Tom Bawden, Dan Sabbagh Media Editor, Eddie Lyle CEO, Gary Jacob, Peter Stiff, Tim Reid, Richard Ford Home Correspondent, David Lloyd Hughes, Chloe Lambert, Rhys Blakely, David Hands, Charles Bremner, Graham Keeley, Jack Sidders, Marie Tourres, David Charter, Susan Thompson, Edward Gorman, Hugo Rifkind, Bob Wright, James Mottram, Tim Teeman, Robert Skidelsky, Russell Kempson, Emma Mahony, Edward Fennell, Suzy Jagger, Gary Duncan Economics Editor, Kelly Brook, Lisa Armstrong, Mark Henderson Science Editor, Sam Coates, Christopher Martin-Jenkins, Ann Treneman, Rob Wright, Jeremy Streeten, Tony Evans, Raymond Keene, Christine Buckley, Matt Hughes, Christine Buckley Industrial Editor, Kaveh Solhekol, Johnny Vegas, Tom Coghlan, Jeremy Page, Peta Bee, Alice Thomson, Patrick Hosking, Helen Nugent, Lindsey Bareham, Dr John Meadowcroft Lecturer, Marcus Leroux, Francesca Steele, James Charles, Peter Dixon, Nick Hasell, Carolyn Asome, David Hands Rugby Correspondent, Tom Dart, Kevin Maher, Paul Simons, Chris Haworth, Ian Gray Head of Humanitarian and Emergency Affairs, Anne Ashworth, Nick Szczepanik, Dominic Kennedy, Philip Webster Political Editor, Steve Hawkes, Matthew Parris, George Caulkin, Neil Fisher, Alan Lee, Peter Riddell, Ben MacIntyre, Jeremy Page South Asia Correspondent, Melanie McDonagh, Lucia van der Post, John Naish, David Sinclair, Bojan Pancevski, Martin Waller, Lewis Smith Environment Reporter, Chris Ayres, Valentine Low, Carl Mortished International Business Editor, Stephen Dalton, Colin Davison, Frances Gibb, Tony Halpin, Richard Corbett, Adam Sherwin, Alan Lee Racing Correspondent, Olav Bjortomt, Miles Costello, W. D. Carter, David Robertson, Dr Pam Spurr,

... seeks help as 40 companies a day fail Merck cuts 7,200 jobs Hedge funds crumble Wachovia' ... Diary Law and orderliness In the blue corner Merck loses 7,200 jobs as credit crisis leads ...

2008 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Jonna Lehtonen, Bairong Shen, Mauno Vihinen, Angela Casini, Andrea Scozzafava, Claudiu T. Supuran, Anna‐Kaisa Parkkila, Juha Saarnio, Antti Kivelä, Abdül Waheed, William S. Sly, Seppo Parkkila,

... The sections were finally mounted in Neo-Mount (Merck, Darmstadt, Germany). The stained sections were examined and photographed with a Zeiss Axioskop 40 microscope (Carl Zeiss, Göttingen, Germany). Mouse CA XIII was immunostained ...

Tópico(s): Chemical synthesis and alkaloids

2004 - Elsevier BV | Journal of Biological Chemistry

Jornais Acesso aberto

Andrew Robson, Amanda Andrews, Robert Cole, David Brown, Zhang Xinshi, Greg Hurst Political Correspondent, Gareth Harris, Simon Barnes, Robert Vincent, Robert Napier, Mark Souster, N. Strauss, David Rose, Richard Hobson, Michael Evans Defence Editor, Tessa Jowell, Philip Howard, David Chater, Professor Alex Markham, James Bone, P. B. Knowles, Penny Wark, Geoffrey Howe, Sam Marlowe, Andi Robertson, Sandy Bettison, Geoff Brown, Lucy Bannerman, Ben Webster Transport Correspondent, Pat Gibson, John Clarke, Rob Crilly, Siobhan Kennedy, Warwick Thompson, Gabby Logan, Lucy Drexler, Dominic Walsh, Erica Wagner Literary Editor, Steve Bird, Louise Streets, Tom Bawden, Gary Jacob, Tim Reid, Rosemary Bennett, Dalya Alberge Arts Correspondent, Alan Hamilton, Elizabeth Colman, Ben Machell, Phil Gordon, Sir Richard Johnstone, Sir Sigmund Sternberg, Ron Lewis, Liz Chong, Greg Hurst, Robert Smith, Hugo Rifkind, Derwent May, Daniel McGrory, Gary Duncan Economics Editor, Oliver Kay, Gerard Baker, Sarah Vine, Jane Wheatley, Mark Henderson Science Editor, Andrew Salmon, Christopher Martin-Jenkins, Pete Paphides, David Robertson Business Correspondent, Les Wilson, Rob Wright, John Hopkins Golf Correspondent, Geoffrey Dean, Bernard Lagan, Raymond Keene, Matt Hughes, Sean O'Neill, Kaveh Solhekol, Andrew Drummond, Chris Campling, Peter Lloyd, Bronwen Maddox, Professor Philip Sabin, Helen Nugent, Richard Owen, Lindsey Bareham, Christopher Martin-Jenkins Chief Cricket Correspondent, Marcus Leroux, Mick Hume, Jonathan Oates, Gabriel Rozenberg Economics Reporter, Nick Hasell, Ned Parker, David Hands Rugby Correspondent, Owen Slot Chief Sports Reporter, Julian Muscat, Paul Simons, Steve Jelbert, Michelle Henery, Anne Ashworth, Nick Szczepanik, Jane Shilling, Ian Johns, Alice Fordham, Sonia Verma, Russell Jenkins, Neil Fisher, Peter Riddell, Ben MacIntyre, Josh Ball, Allen Robertson, Ben Ainslie Commentary, Lucia van der Post, David Sanderson, Catherine Philp, Martin Waller, Michael Horsnell, Lewis Smith Environment Reporter, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Angus Batey, Stuart Birch, Dr Thomas Stuttaford, Stephen Dalton, Richard Morrison, Dr Mowaffak Al-Rubaie National Security Adviser, Michael Evans, Owen Slot, Olav Bjortomt, E. S. Harvey, Jane Macartney, Catherine Riley Motoring Editor, Joe Bolger, Amanda Andrews Media Reporter, Elizabeth Judge Telecoms Correspondent,

... options Alert hits Blacks Quote of the day Merck opening Business big shot Internet sales push Next ... of dropping prices Uplifting figures KKR tipped as Merck seeks to sell its generic drugs unit OECD ...

2007 - Gale Group | TDA

Revisão Acesso aberto Revisado por pares

Sheila Annie Peters, Carl Petersson, Andree Blaukat, Joern-Peter Halle, Hugues Dolgos,

High-quality dose predictions based on a good understanding of target engagement is one of the main translational goals in drug development. Here, we systematically evaluate active human dose predictions for 15 Merck KGaA/EMD Serono assets spanning several modalities and therapeutic areas. Using case studies, we illustrate the value of adhering to the translational best practices of having an exposure-response relationship in an appropriate animal model; having validated, translatable pharmacodynamic ( ...

Tópico(s): Carcinogens and Genotoxicity Assessment

2020 - Elsevier BV | Drug Discovery Today