Produção Nacional
Revisado por pares
Fillipe V. Rocha, Vincent Barra, Saulo Santesso Garrido, Francine Alessandra Manente, Iracilda Zeppone Carlos, Javier Ellena, Andrea S. C. Fuentes, Arnaud Gautier, Laurent Morel, Antônio E. Mauro, Adelino V.G. Netto,
The synthesis and characterization of the complexes [PdX(PPh 3 )(4-MeT)]X (4-MeT = 4-methyl-3-thiosemicarbazide; PPh 3 = triphenylphosphine; X = Cl, Br, I, SCN) have been described. The complexes were evaluated for in vitro activity as cytotoxic agents on tumor cells and also as cathepsin B and topoisomerase I and II inhibitors. • Cationic palladium compounds were prepared bearing thiosemicarbazide and triphenylphosphine. • The compounds were more cytotoxic than cisplatin against LM3 and MCF-7 tumor cells. • The ...
Tópico(s): Synthesis and biological activity
2016 - Elsevier BV | Journal of Inorganic Biochemistry
Megan T. Haug, Ellena S. King, Hildegarde Heymann, Carlos H. Crisosto,
Abstract A trained sensory panel evaluated the 6 fig cultivars currently sold in the California dried fig market. The main flavor and aroma attributes determined by the sensory panel were “caramel,” “honey,” “raisin,” and “fig,” with additional aroma attributes: “common date,” “dried plum,” and “molasses.” Sensory differences were observed between dried fig cultivars. All figs were processed by 2 commercial handlers. Processing included potassium sorbate as a preservative and SO 2 application as an antibrowning ...
Tópico(s): Plant Physiology and Cultivation Studies
2013 - Wiley | Journal of Food Science
Produção Nacional
Alex Shimura Yamashita, Fábio Santos Lira, José Cesar Rosa Neto, Ellena C. Paulino, Patrı́cia C. Brum, Carlos Eduardo Negrão, Ronaldo Vagner Thomatieli dos Santos, Miguél L. Batista, Claudia Oller do Nascimento, Lila Missae Oyama, Marília Seelaender,
The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15 weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n = 8) or trained (trained HFD, n = 8); or submitted to energy-restriction (ER), which were sedentary ( ...
Tópico(s): Exercise and Physiological Responses
2010 - Elsevier BV | Cytokine
Antonio Toscano, Paolo Capuano, Andrea Costamagna, Carlo Burzio, Marco Ellena, Valentina Scala, Daniela Pasero, Mauro Rinaldi, Luca Brazzi,
Regional anesthesia with thoracic wall blocks could represent an opioid-sparing alternative for mitral valve surgery in right minithoracotomy (mini-MVS). For the present study, an opioid-free analgesia using continuous deep serratus anterior plane block was compared with intravenous morphine.Prospective, observational cohort study.Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Turin, Italy.The present study enrolled patients who underwent mini-MVS from ...
Tópico(s): Nausea and vomiting management
2020 - Elsevier BV | Journal of Cardiothoracic and Vascular Anesthesia
Produção Nacional
Rodolfo Moreno‐Fuquen, Geraldine Hernández, Javier Ellena, Carlos A. De Simone, Juan C. Tenório,
In the title compound, C14H8BrNO5, the benzene rings form a dihedral angle of 62.90 (7)°. The central ester group is twisted away from the nitro-substituted and bromo-substituted rings by 71.67 (7) and 8.78 (15)°, respectively. The nitro group forms a dihedral angle of 7.77 (16)° with the benzene ring to which it is attached. In the crystal, mol-ecules are linked by weak C-H⋯O inter-actions, forming C(12) chains which run along [001]. Halogen-halogen inter-actions [Br⋯Br = 3.523 (3) Å] within the chains ...
Tópico(s): Synthesis and biological activity
2013 - International Union of Crystallography | Acta Crystallographica Section E Structure Reports Online
Produção Nacional
Revisado por pares
João P. Barolli, Rodrigo S. Corrêa, Fábio S. Miranda, Juliana Silva Ribeiro, Carlos Bloch, Javier Ellena, Virtudes Moreno, Márcia R. Cominetti, Alzir A. Batista,
This paper describes a new series of four DNA-intercalating agents with promising anticancer activities, based on ruthenium(II) with the planar ligand dpqQX(dppb = 1,4-bis(diphenylphosphine)butane and PPh 3 = triphenylphosphine) were characterized by 31 P{ 1 H} nuclear magnetic resonance (NMR) and infrared spectroscopies, cyclic voltammetry, molar conductance measurements, elemental analysis, mass spectrometry and X-ray diffraction analysis for complex ct-[RuCl 2 (PPh 3 ) 2 (dpqQX)].Their in vitro cytotoxic ...
Tópico(s): DNA and Nucleic Acid Chemistry
2017 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Maura Pozzi, Stefano Passini, María Chayinska, Davide Morselli, Adriano Mauro Ellena, Anna Włodarczyk, Carlo Pistoni,
Abstract By integrating the insights from social identity research on collective action, this article examines the social‐psychological mechanisms behind the emergence of the 2019–20 ‘ Chile despertó ’ social movement, a major Latin American revolt against the government's price hikes. Using survey data collected among Chilean activists ( N = 549) and non‐activists (i.e., members of broader society, N = 234), we analyse two major explanatory collective action frameworks: that is, the social identity model ...
Tópico(s): Social Media and Politics
2022 - Wiley | Journal of Community & Applied Social Psychology
Produção Nacional
Revisado por pares
Paulo S. Carvalho, Luan F. Diniz, Juan C. Tenório, Matheus S. Souza, Chris H. J. Franco, Rafael Cardoso Rial, Rodrigo Cardoso de Oliveira, Carlos Eduardo Domingues Nazário, Javier Ellena,
Reacting paroxetine HCl with oxalic, maleic, fumaric and l -tartaric acids results in the formation of novel molecular salts.
Tópico(s): Crystallization and Solubility Studies
2019 - Royal Society of Chemistry | CrystEngComm
Produção Nacional
Rodolfo Moreno‐Fuquen, Geraldine Hernández, Javier Ellena, Carlos A. De Simone, Juan C. Tenório,
In the title compound, C14H8ClNO5, the benzene rings form a dihedral angle of 19.55 (9)°. The mean plane of the central ester group [r.m.s. deviation = 0.024 Å] forms dihedral angles of 53.28 (13) and 36.93 (16)°, respectively, with the nitro- and chloro-substituted rings. The nitro group forms a dihedral angle of 19.24 (19)° with the benzene ring to which it is attached. In the crystal, mol-ecules are linked by weak C-H⋯O hydrogen bonds, forming C(7) chains, which run along [100].
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2013 - International Union of Crystallography | Acta Crystallographica Section E Structure Reports Online
Cristián Balbontín, H. G. Ayala, Richard M. Bastías, Gerardo Tapia, Miguel Ellena, Carolina A. Torres, José Antonio Yuri, José Quero‐García, Juan Carlos Ríos, Hermán Silva,
Rain-induced cracking in fruits of sweet cherry (Prunus avium [L.]) is a problem in most producing areas of the world and causes significant economic losses.Different orchard management practices have been employed to reduce the severity of this problem, although a complete solution is not yet available.Fruit cracking is a complex phenomenon and there are many factors that seem to be involved in its development.During the last decade, genomic and biochemical approaches have provided new insights on ...
Tópico(s): Plant responses to water stress
2013 - Instituto de Investigaciones Agropecuarias, INIA | Chilean journal of agricultural research
Maura Pozzi, Roberto Fasanelli, Elena Marta, Adriano Mauro Ellena, Virgilio Giuseppe, Di Taranto Adriana, Carlo Pistoni,
In Italian society, known for the massive presence of so-called traditional families, different forms of it are nowadays spreading. The scientific and political debates on this issue are very intense and the common view of family is changing. Taking as a reference the theory of social representations and in particular the central nucleus theory, the present study aims to evoke the social representation (SR) of family in two different Italian groups: 220 young adults and 83 older adults. A semi-structured ...
Tópico(s): Community Health and Development
2021 - SAGE Publishing | Journal of Family Issues
Produção Nacional
Revisado por pares
Andrea Pastrana‐Dávila, Andres Amaya-Flórez, Carlos Aranaga, Javier Ellena, Mario A. Macías, Edwin Flórez‐López, Richard F. D’Vries,
In this work, the study of the synthesis methodology to obtain dibenzylamine derivates as intermediates for the formation of dithicarbamate ligands (DTC) and its coordination compounds was conducted. Four molecules derived from dibenzylamine were synthesized by two methodologies: classical (reflux) and microwave. From these amines, Four dithiocarbamate ligands (DTC): dibenzyldithiocarbamate, N-benzyl-1-(4-methoxyphenyl)dithiocarbamate, N-benzyl-1-(4-chlorophenyl)dithiocarbamate, and N-benzyl-1-(3-nitrophenyl) ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2021 - Elsevier BV | Journal of Molecular Structure
Produção Nacional
Revisado por pares
Jorge L. M. Tributino, Carolina D. Duarte, Rodrigo S. Corrêa, A.C. Doriguetto, Javier Ellena, Nelilma Correia Romeiro, Newton G. Castro, Ana Luísa P. Miranda, Eliezer J. Barreiro, Carlos Alberto Manssour Fraga,
We described herein the molecular design of novel in vivo anti-inflammatory 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives (1) planned by applying the molecular hybridization approach. This work also points out to the discovery of LASSBio-930 (1c) as a novel anti-inflammatory and anti-hyperalgesic prototype, which was able to reduce carrageenan-induced rat paw edema with an ED(50) of 97.8 micromol/kg, acting mainly as a non-selective COX inhibitor.
Tópico(s): Bioactive Compounds and Antitumor Agents
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry
Produção Nacional
Revisado por pares
Marciela Scarpellini, José Carlos Toledo, Ademir Neves, Javier Ellena, E.E. Castellano, Douglas Wagner Franco,
The present paper describes a new tripodal ligand containing imidazole and pyridine arms and its first cis-[Ru I I I (L)(Cl) 2 ]ClO 4 complex (1). The crystal structure of 1 shows Ru I I I in a distorted octahedral geometry, in which two chloride ions, cis-positioned to each other, are coordinated besides the four nitrogen atoms from the tetradentate ligand L. The cyclic voltammogram of 1 exhibits three redox processes at -67, +73 and +200 mV versus SCE, which are attributed to the Ru I I I /Ru I I couple ...
Tópico(s): Oxidative Organic Chemistry Reactions
2004 - Elsevier BV | Inorganica Chimica Acta
Produção Nacional
Revisado por pares
Inara de Aguiar, Francisco C. A. Lima, Javier Ellena, V.R.S. Malta, Rose Maria Carlos,
355 nm light irradiation of fac-[Mn(CO)3(phen)(imH)]+ (fac-1) produces the mer-1 isomer and a long lived radical which can be efficiently trapped by electron acceptor molecules. EPR experiments shows that when excited, the manganese(I) complex can be readily oxidized by one-electron process to produce Mn(II) and phen−. In the present study, DFT calculations have been used to investigated the photochemical isomerization of the parent Mn(I) complex and to characterize the electronic structures of the ...
Tópico(s): Metal complexes synthesis and properties
2011 - Elsevier BV | Computational and Theoretical Chemistry
Daniel L. Levin, Samira Bell, Reijo Sund, Sirpa Hartikainen, Jaakko Tuomilehto, Eero Pukkala, Ilmo Keskimäki, Ellena Badrick, Andrew G. Renehan, Iain Buchan, Samantha L. Bowker, Jasjeet K. Minhas‐Sandhu, Zafar Zafarí, Carlo A. Marra, Jeffrey Johnson, Bruno H. Stricker, André G. Uitterlinden, Albert Hofman, Rikje Ruiter, Catherine E. de Keyser, Thomas M. MacDonald, Sarah H. Wild, Paul McKeigue, Helen M. Colhoun,
The evidence on the association between pioglitazone use and bladder cancer is contradictory, with many studies subject to allocation bias. The aim of our study was to examine the effect of exposure to pioglitazone on bladder cancer risk internationally across several cohorts. The potential for allocation bias was minimised by focusing on the cumulative effect of pioglitazone as the primary endpoint using a time-dependent approach.Prescription, cancer and mortality data from people with type 2 diabetes ...
Tópico(s): Cancer, Lipids, and Metabolism
2014 - Springer Science+Business Media | Diabetologia
Ellena S. King, Helene Hopfer, Megan T. Haug, Jennifer D. Orsi, Hildegarde Heymann, Gayle M. Crisosto, Carlos H. Crisosto,
Abstract: Twelve fig cultivars, including cultivars destined for the fresh and dried markets, were harvested from 6 locations and evaluated by a trained panel using descriptive sensory analysis. Instrumental measurements were taken at harvest and also during sensory analysis. Each fresh fig cultivar had a characteristic appearance and flavor sensory profile regardless of the source. The primary flavor attributes used to describe the fig cultivars were “fruity,”“melon,”“stone fruit,”“berry,”“citrus,”“ ...
Tópico(s): Banana Cultivation and Research
2012 - Wiley | Journal of Food Science
Produção Nacional
Revisado por pares
Rodolfo Moreno‐Fuquen, Juan C. Tenório, Javier Ellena, Carlos A. De Simone, Leandro Ribeiro,
In the title compound, C(11)H(7)NO(4), there is a dihedral angle of 45.80 (7)° between the planes of the benzene and maleimide rings. The presence of O-H···O hydrogen bonding and weak C-H···O interactions allows the formation of R(3)(3)(19) edge-connected rings parallel to the (010) plane. Structural, spectroscopic and theoretical studies were carried out. Density functional theory (DFT) optimized structures at the B3LYP/6-311 G(d,p) and 6-31++G(d,p) levels are compared with the experimentally determined ...
Tópico(s): Metal complexes synthesis and properties
2011 - Wiley | Acta Crystallographica Section C Crystal Structure Communications
Produção Nacional
Revisado por pares
Carlos Fernández-Ruiz, Natalia Álvarez, Analu Rocha, Javier Ellena, Antonio J. Costa‐Filho, Alzir A. Batista, Gianella Facchin,
Searching for new copper compounds which may be useful as antitumor drugs, a series of new [Cu(L-dipeptide)(batho)] (batho:4,7-diphenyl-1,10-phenanthroline, L-dipeptide: Gly-Val, Gly-Phe, Ala-Gly, Ala-Ala, Ala-Phe, Phe-Ala, Phe-Val and Phe-Phe) complexes were synthesized and characterized. To interpret the experimental IR spectra, [Cu(ala-gly)(batho)] was modelled in the gas phase using DFT at the B3LYP/LANL2DZ level of theory and the calculated vibrational frequencies were analyzed. Solid-state characterization ...
Tópico(s): Crystal structures of chemical compounds
2023 - Multidisciplinary Digital Publishing Institute | Molecules
Mark S. Graham, Carole H. Sudre, Anna May, Michela Antonelli, Benjamin Murray, Thomas Varsavsky, Kerstin Kläser, Liane S. Canas, Erika Molteni, Marc Modat, David Drew, Long H. Nguyen, Lorenzo Polidori, Somesh Selvachandran, Christina Hu, Joan Capdevila Pujol, Alexander Hammers, Andrew T. Chan, Jonathan Wolf, Tim D. Spector, Claire J. Steves, Sébastien Ourselin, Cherian Koshy, Amy Ash, Emma L. Wise, Nathan Moore, Matilde Mori, Nick Cortes, Jessica Lynch, Stephen P. Kidd, Derek Fairley, Tanya Curran, James McKenna, Helen Adams, Christophe Fraser, Tanya Golubchik, David Bonsall, Mohammed O. Hassan-Ibrahim, Cassandra S. Malone, Benjamin J. Cogger, Michelle Wantoch, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, Michaela John, Robert Beer, Safiah Afifi, Siân Morgan, Angela Marchbank, Anna Price, Christine Kitchen, Huw Gulliver, Ian Merrick, Joel Southgate, Martyn F. Guest, Robert J. Munn, Trudy Workman, Thomas R. Connor, William Fuller, Catherine Bresner, Luke B. Snell, Amita Patel, Themoula Charalampous, Gaia Nebbia, Rahul Batra, Jonathan Edgeworth, Samuel C. Robson, Angela H. Beckett, David M. Aanensen, Anthony P. Underwood, Corin Yeats, Khalil Abudahab, Ben Taylor, Mirko Menegazzo, Gemma Clark, Darren Smith, Manjinder Khakh, Vicki M. Fleming, Michelle M. Lister, Hannah C. Howson‐Wells, Louise Berry, Tim Boswell, Amelia Joseph, Iona Willingham, Carl Jones, Christopher W. Holmes, Paul Bird, Thomas Helmer, Karlie Fallon, Julian W. Tang, Veena Raviprakash, Sharon L. Campbell, Nicola Sheriff, Victoria Blakey, Lesley-Anne Williams, Matthew Loose, Nadine Holmes, Christopher Moore, Matthew Carlile, Victoria Wright, Fei Sang, Johnny Debebe, Francesc Coll, Adrian W. Signell, Gilberto Betancor, Harry Wilson, Sahar Eldirdiri, Anita Kenyon, Thomas P. Davis, Oliver G. Pybus, Louis du Plessis, Alex E. Zarebski, Jayna Raghwani, Moritz U. G. Kraemer, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Marina Escalera Zamudio, Bernardo Gutiérrez, M. Estée Török, William L. Hamilton, Ian Goodfellow, Grant Hall, Aminu S. Jahun, Yasmin Chaudhry, Myra Hosmillo, Malte L. Pinckert, Iliana Georgana, Samuel Moses, Hannah Lowe, Luke Bedford, Jonathan D. Moore, Susanne Stonehouse, Chloe L. Fisher, Ali Raza Awan, John Boyes, Judith Breuer, Kathryn Harris, Julianne R. Brown, Divya Shah, Laura Atkinson, Jack C. D. Lee, Nathaniel Storey, Flavia Flaviani, Adela Alcolea-Medina, Rebecca Williams, Gabrielle Vernet, Michael Chapman, Lisa J. Levett, Judith Heaney, Wendy Chatterton, Monika Pusok, Li Xu-McCrae, Darren Smith, Matthew Bashton, Gregory R. Young, Alison Holmes, Paul Randell, Alison Cox, Pinglawathee Madona, Frances Bolt, James Price, Siddharth Mookerjee, Manon Ragonnet‐Cronin, Fabrícia F. Nascimento, David Jorgensen, Igor Siveroni, Rob Johnson, Olivia Boyd, Lily Geidelberg, Erik Volz, Aileen Rowan, Graham P. Taylor, Katherine Smollett, Nicholas J. Loman, Joshua Quick, Claire McMurray, Joanne Stockton, Samuel M. Nicholls, Will Rowe, Radoslaw Poplawski, Alan McNally, Rocio T. Martinez Nunez, Jenifer Mason, Trevor I. Robinson, Elaine O’Toole, Joanne Watts, Cassie Breen, Angela Cowell, Graciela Sluga, Nicholas W. Machin, Shazaad Ahmad, Ryan P. George, Fenella Halstead, Venkat Sivaprakasam, Wendy Hogsden, Chris J. Illingworth, Christopher Jackson, Emma C. Thomson, James G. Shepherd, Patawee Asamaphan, Marc Niebel, Kathy Li, Rajiv Shah, Natasha Jesudason, L. Tong, Alice Broos, Daniel Mair, Jenna Nichols, Stephen Carmichael, Kyriaki Nomikou, Elihú Aranday-Cortés, Natasha M. Johnson, Igor Starinskij, Ana da Silva Filipe, David L. Robertson, Richard Orton, Joseph Hughes, Vattipally B. Sreenu, Joshua B. Singer, Seema Nickbakhsh, Antony Hale, Louissa Macfarlane-Smith, Katherine L. Harper, Holli Carden, Yusri Taha, Brendan Payne, Shirelle Burton-Fanning, Sheila Waugh, Jennifer Collins, Gary Eltringham, Steven Rushton, Sarah H. O’Brien, Allan Bradley, Alasdair Maclean, Guy Mollett, Rachel Blacow, Kate Templeton, M. McHugh, Rebecca Dewar, Elizabeth Wastenge, Samir Dervisevic, Rachael Stanley, Emma Meader, Lindsay Coupland, Louise Smith, Clive Graham, Edward Barton, Debra Padgett, Garren Scott, Emma Swindells, Jane Greenaway, Andrew Nelson, Clare M. McCann, Wen C. Yew, Monique Andersson, Tim Peto, Anita Justice, David W. Eyre, Derrick W. Crook, Tim J. Sloan, Nichola Duckworth, Sarah Walsh, Anoop Chauhan, Sharon Glaysher, Kelly Bicknell, Sarah Wyllie, Scott Elliott, Allyson Lloyd, Robert Impey, Nick Levene, Lynn Monaghan, Declan Bradley, Tim Wyatt, Elias Allara, Clare Pearson, Husam Osman, Andrew Bosworth, Esther Robinson, Peter Muir, Ian B. Vipond, Richard Hopes, Hannah M. Pymont, Stephanie Hutchings, Martin D. Curran, Surendra Parmar, Angie Lackenby, Tamyo Mbisa, Steven G. Platt, Shahjahan Miah, David Bibby, Carmen de Guerrero Manso, Jonathan Hubb, Meera Chand,
BackgroundThe SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease course, reinfection rates, or transmissibility.MethodsWe did an ecological study to examine the association between the regional proportion of infections with the SARS-CoV-2 B.1.1.7 variant and reported symptoms, disease course, rates of reinfection, and transmissibility. ...
Elsevier BV
Katherine A. Twohig, Tommy Nyberg, Asad Zaidi, Simon Thelwall, Mary Sinnathamby, Shirin Aliabadi, Shaun R. Seaman, Ross Harris, Russell Hope, Jamie Lopez Bernal, Eileen Gallagher, André Charlett, Daniela De Angelis, Anne M. Presanis, Gavin Dabrera, Cherian Koshy, Amy Ash, Emma L. Wise, Nathan W. Moore, Matilde Mori, Nick Cortes, Jessica Lynch, Stephen P. Kidd, Derek Fairley, Tanya Curran, James P. McKenna, Helen Adams, Christophe Fraser, Tanya Golubchik, David Bonsall, Mohammed O. Hassan-Ibrahim, Cassandra S. Malone, Benjamin J. Cogger, Michelle Wantoch, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, Michaela John, Robert Beer, Safiah Afifi, Siân Morgan, Angela Marchbank, Anna Price, Christine Kitchen, Huw Gulliver, Ian Merrick, Joel Southgate, Martyn F. Guest, R. W. Munn, Trudy Workman, Thomas R. Connor, William Fuller, Catherine Bresner, Luke B. Snell, Amita Patel, Themoula Charalampous, Gaia Nebbia, Rahul Batra, Jonathan D. Edgeworth, Samuel C. Robson, Angela H. Beckett, David M. Aanensen, Anthony Underwood, Corin Yeats, Khalil Abudahab, Ben Taylor, Mirko Menegazzo, Gemma Clark, Darren Smith, Manjinder Khakh, Vicki M. Fleming, Michelle M. Lister, Hannah C. Howson‐Wells, Louise Berry, Tim Boswell, Amelia Joseph, Iona Willingham, Carl Jones, Christopher W. Holmes, Paul Bird, Thomas Helmer, Karlie Fallon, Julian W. Tang, Veena Raviprakash, Sharon L. Campbell, Nicola Sheriff, Victoria Blakey, Lesley-Anne Williams, Matthew Loose, Nadine Holmes, Christopher Moore, Matthew Carlile, Victoria Wright, Fei Sang, Johnny Debebe, Francesc Coll, Adrian W. Signell, Gilberto Betancor, Harry Wilson, Sahar Eldirdiri, Anita Kenyon, Thomas P. Davis, Oliver G. Pybus, Louis du Plessis, Alex E. Zarebski, Jayna Raghwani, Moritz U. G. Kraemer, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Marina Escalera Zamudio, Bernardo Gutiérrez, M. Estée Török, William L. Hamilton, Ian Goodfellow, Grant Hall, Aminu S. Jahun, Yasmin Chaudhry, Myra Hosmillo, Malte L. Pinckert, Iliana Georgana, Samuel Moses, Hannah Lowe, Luke Bedford, Jonathan D. Moore, Susanne Stonehouse, Chloe L. Fisher, Ali Raza Awan, John Boyes, Judith Breuer, Kathryn Harris, Julianne R. Brown, Divya Shah, Laura Atkinson, Jack C. D. Lee, Nathaniel Storey, Flavia Flaviani, Adela Alcolea-Medina, R. M. E. Williams, Gabrielle Vernet, Michael Spencer Chapman, Lisa J. Levett, Judith Heaney, Wendy Chatterton, Monika Pusok, Li Xu-McCrae, Darren Smith, Matthew Bashton, Gregory R. Young, Alison Holmes, Paul Randell, Alison Cox, Pinglawathee Madona, Frances Bolt, James Price, Siddharth Mookerjee, Manon Ragonnet‐Cronin, Fabrícia F. Nascimento, David Jorgensen, Igor Siveroni, Rob Johnson, Olivia Boyd, Lily Geidelberg, Erik Volz, Aileen Rowan, Graham P. Taylor, Katherine Smollett, Nicholas J. Loman, Joshua Quick, Claire McMurray, Joanne Stockton, Samuel M. Nicholls, Will Rowe, Radoslaw Poplawski, Alan McNally, Rocio Martinez Nunez, Jenifer Mason, Trevor I. Robinson, Elaine O’Toole, Joanne Watts, Cassie Breen, Angela Cowell, Graciela Sluga, Nicholas Machin, Shazaad Ahmad, Ryan P. George, Fenella Halstead, Venkat Sivaprakasam, Wendy Hogsden, Christopher J. R. Illingworth, Christopher Jackson, Emma C. Thomson, James G. Shepherd, Patawee Asamaphan, Marc Niebel, Kathy Li, Rajiv Shah, Natasha Jesudason, L. Tong, Alice Broos, Daniel Mair, Jenna Nichols, Stephen Carmichael, Kyriaki Nomikou, Elihú Aranday-Cortés, Natasha M. Johnson, Igor Starinskij, Ana da Silva Filipe, David L. Robertson, Richard Orton, Joseph Hughes, Vattipally B. Sreenu, Joshua B. Singer, Seema Nickbakhsh, Antony Hale, Louissa Macfarlane-Smith, Katherine L. Harper, Holli Carden, Yusri Taha, Brendan Payne, Shirelle Burton-Fanning, Sheila Waugh, Jennifer Collins, Gary Eltringham, Steven Rushton, Sarah H. O’Brien, Amanda J. Bradley, Alasdair Maclean, Guy Mollett, Rachel Blacow, Kate Templeton, M. McHugh, Rebecca Dewar, Elizabeth Wastenge, Samir Dervisevic, Rachael Stanley, Emma Meader, Lindsay Coupland, Louise Smith, Clive Graham, Edward Barton, Debra Padgett, Garren Scott, Emma Swindells, Jane Greenaway, Andrew Nelson, Clare M. McCann, Wen Shan Yew, Monique Andersson, Tim Peto, Anita Justice, David W. Eyre, Derrick W. Crook, Tim J. Sloan, Nichola Duckworth, Sarah Walsh, Anoop Chauhan, Sharon Glaysher, Kelly Bicknell, Sarah Wyllie, Scott Elliott, Allyson Lloyd, Robert Impey, Nick Levene, Lynn Monaghan, Declan Bradley, Tim Wyatt, Elias Allara, Clare Pearson, Husam Osman, Andrew Bosworth, Esther Robinson, Peter Muir, Ian B. Vipond, Richard Hopes, Hannah M. Pymont, Stephanie Hutchings, Martin D. Curran, Surendra Parmar, Angie Lackenby, Tamyo Mbisa, Steven G. Platt, Shahjahan Miah, David Bibby, Carmen de Guerrero Manso, Jonathan Hubb, Meera Chand, Gavin Dabrera, Mary Ramsay, Daniel Bradshaw, Alicia Thornton, Richard Myers, Ulf Schaefer, Natalie Groves,
The SARS-CoV-2 delta (B.1.617.2) variant was first detected in England in March, 2021. It has since rapidly become the predominant lineage, owing to high transmissibility. It is suspected that the delta variant is associated with more severe disease than the previously dominant alpha (B.1.1.7) variant. We aimed to characterise the severity of the delta variant compared with the alpha variant by determining the relative risk of hospital attendance outcomes.
Elsevier BV
Produção Nacional
A.C. Doriguetto, Carlos Henrique Tomich de Paula da Silva, Javier Ellena, Gustavo Henrique Goulart Trossini, Chung Man Chin, Elizabeth Igne Ferreira,
The title compound, C7H8N4O5, which is a potential anti-Chagas' derivative, was synthesized using a simple hydroxymethylation method in a basic medium with formaldehyde. The structure reveals two infinite two-dimensional networks in the (\overline{1}02) and (001) planes, stabilized by intermolecular hydrogen bonds.
Tópico(s): Structural and Chemical Analysis of Organic and Inorganic Compounds
2005 - International Union of Crystallography | Acta Crystallographica Section E Structure Reports Online
Produção Nacional
Revisado por pares
Rafael Aparecido Carvalho Souza, Vito Labruna Cunha, Jonathan Henrique de Souza, Carlos Henrique Gomes Martins, Eduardo de Faria Franca, Marcos Pivatto, Javier Ellena, Leandro A. Faustino, Antonio Otávio T. Patrocínio, Victor M. Deflon, Pedro I. S. Maia, Carolina G. Oliveira,
In the present work, the synthesis, characterization, antifungal activity, molecular docking study and in silico approach of five thiosemicarbazone derivatives and their corresponding zinc(II) complexes are described. The compounds were characterized by elemental analysis, IR, UV-Vis and NMR spectroscopic measurements, molar conductivity measurements, emission spectra, high-resolution mass spectrometry and X ray study. The antifungal activity of the free ligands and synthesized compounds was preliminarily ...
Tópico(s): Organometallic Compounds Synthesis and Characterization
2022 - Elsevier BV | Journal of Inorganic Biochemistry
Produção Nacional
Revisado por pares
Ellena C. Paulino, Julio Cesar Batista Ferreira, Luiz R. G. Bechara, Jeane Mike Tsutsui, Wilson Mathias, Fábio Bessa Lima, Dulce Elena Casarini, Antônio Carlos Cicogna, Patrı́cia C. Brum, Carlos Eduardo Negrão,
Previous studies show that exercise training and caloric restriction improve cardiac function in obesity. However, the molecular mechanisms underlying this effect on cardiac function remain unknown. Thus, we studied the effect of exercise training and/or caloric restriction on cardiac function and Ca(2+) handling protein expression in obese rats. To accomplish this goal, male rats fed with a high-fat and sucrose diet for 25 weeks were randomly assigned into 4 groups: high-fat and sucrose diet, high- ...
Tópico(s): Cardiovascular Effects of Exercise
2010 - Lippincott Williams & Wilkins | Hypertension
Produção Nacional
Revisado por pares
L.C.M. Costa, Geraldo Μ. de Lima, José Roberto da Silveira Maia, Carlos A. L. Filgueiras, A.C. Doriguetto, Javier Ellena,
A series of organotin(IV) derivatives were obtained employing 2,6-pyridinedicarboxylate as ligand: [{SnBu3(OOC)2C5H3N}n] (1), [SnBuCl(OOC)2C5H3N] (2) and [Sn(CHCH2)2(OOC)2C5H3N] (3). They were fully characterised by multinuclear NMR [1H, 13C{1H}, and 119Sn{1H}], IR spectroscopies and elemental analysis. In addition suitable crystals of (3) have shown a dimmeric arrangement by X-ray crystallographic studies, held together by Sn–O intermolecular interactions which persists in solution. The crystal packing ...
Tópico(s): Crystal structures of chemical compounds
2004 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Produção Nacional
Revisado por pares
Gustavo Von Poelhsitz, Renata C. Lima, Rose Maria Carlos, Antônio G. Ferreira, Alzir A. Batista, Alexandre Suman de Araújo, Javier Ellena, E.E. Castellano,
[RuCl3(NO)(P–P)], [P–P = R2P(CH2)nPR2 (n = 1–3) and R2P(CH2)POR2, PR2–CHCH–PR2, R = Ph and (C6H11)2P-(CH2)2-P(C6H11)2] were obtained and characterized by 31P {1H} NMR, IR spectroscopies and cyclic voltammetry. The structures of fac-[RuCl3(NO)(P–P)], P–P = dppm (1), dppe (2), c-dppen (3) and dppp (4), mer-[RuCl3(NO)(dcpe)] (6a) and mer-[RuCl3(NO)(dppmO)] (7) have been determined by X-ray diffraction. Photochemical isomerization of fac- to mer-[RuCl3(NO)(P–P)] was observed under white light in a CH2Cl2 solution and ...
Tópico(s): Magnetism in coordination complexes
2006 - Elsevier BV | Inorganica Chimica Acta
Dinesh Aggarwal, Andrew J. Page, Ulf Schaefer, George M. Savva, Richard Myers, Erik Volz, Nicholas Ellaby, Steven G. Platt, Natalie Groves, Eileen Gallagher, Niamh Tumelty, Thanh Le-Viet, G. Hughes, Cong Chen, Charlie Turner, Sophie Logan, Abbie Harrison, Cherian Koshy, Amy Ash, Emma L. Wise, Nathan Moore, Matilde Mori, Nick Cortes, Jessica Lynch, Stephen P. Kidd, Derek Fairley, Tanya Curran, James McKenna, Helen Adams, Christophe Fraser, Tanya Golubchik, David Bonsall, Mohammed O. Hassan-Ibrahim, Cassandra S. Malone, Benjamin J. Cogger, Michelle Wantoch, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, Michaela John, Robert Beer, Safiah Afifi, Sian Morgan, Angela Marchbank, Anna Price, Christine Kitchen, Huw Gulliver, Ian Merrick, Joel Southgate, Martyn F. Guest, Robert J. Munn, Trudy Workman, Thomas R. Connor, William Fuller, Catherine Bresner, Luke B. Snell, Amita Patel, Themoula Charalampous, Gaia Nebbia, Rahul Batra, Jonathan Edgeworth, Samuel C. Robson, Angela H. Beckett, David M. Aanensen, Anthony P. Underwood, Corin Yeats, Khalil Abudahab, Ben Taylor, Mirko Menegazzo, Gemma Clark, Wendy Smith, Manjinder Khakh, Vicki M. Fleming, Michelle M. Lister, Hannah C. Howson‐Wells, Louise Berry, Tim Boswell, Amelia Joseph, Iona Willingham, C. Wayne Jones, Christopher W. Holmes, Paul Bird, Thomas Helmer, Karlie Fallon, Julian W. Tang, Veena Raviprakash, Stephen Campbell, Nicola Sheriff, Victoria Blakey, Lesley-Anne Williams, Matthew Loose, Nadine Holmes, Christopher Moore, Matthew Carlile, Victoria Wright, Fei Sang, Johnny Debebe, Francesc Coll, Adrian W. Signell, Gilberto Betancor, Harry Wilson, Sahar Eldirdiri, Anita Kenyon, Thomas Davis, Oliver G. Pybus, Louis du Plessis, Alex E. Zarebski, Jayna Raghwani, Moritz U. G. Kraemer, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Marina Escalera Zamudio, Bernardo Gutiérrez, M. Estée Török, William L. Hamilton, Ian Goodfellow, Grant Hall, Aminu S. Jahun, Yasmin Chaudhry, Myra Hosmillo, Malte L. Pinckert, Iliana Georgana, Samuel Moses, Hannah Lowe, Luke Bedford, Jonathan P. Moore, Susanne Stonehouse, Chloe L. Fisher, Ali Raza Awan, John Boyes, Judith Breuer, Kathryn Harris, Julianne R. Brown, Divya Shah, Laura Atkinson, Jack C. D. Lee, Nathaniel Storey, Flavia Flaviani, Adela Alcolea-Medina, Rebecca Williams, Gabrielle Vernet, Michael Chapman, Lisa J. Levett, Judith Heaney, Wendy Chatterton, Monika Pusok, Li Xu-McCrae, Darren Smith, Matthew Bashton, Gregory R. Young, Alison Holmes, Paul Randell, Alison Cox, Pinglawathee Madona, Frances Bolt, James Price, Siddharth Mookerjee, Manon Ragonnet‐Cronin, Fabrícia F. Nascimento, David Jorgensen, Igor Siveroni, Rob Johnson, Olivia Boyd, Lily Geidelberg, Erik Volz, Aileen Rowan, Graham P. Taylor, Katherine Smollett, Nicholas J. Loman, Joshua Quick, Claire McMurray, Joanne Stockton, Sam Nicholls, Will Rowe, Radoslaw Poplawski, Alan McNally, Rocio T. Martinez Nunez, Jenifer Mason, Trevor I. Robinson, Elaine O’Toole, Joanne Watts, Cassie Breen, Angela Cowell, Graciela Sluga, Nicholas W. Machin, Shazaad Ahmad, Ryan P. George, Fenella Halstead, Venkat Sivaprakasam, Wendy Hogsden, Chris J. Illingworth, Chris Jackson, Emma C. Thomson, James G. Shepherd, Patawee Asamaphan, Marc Niebel, Kathy Li, Rajiv Shah, Natasha Jesudason, L. Tong, Alice Broos, Daniel Mair, Jenna Nichols, Stephen Carmichael, Kyriaki Nomikou, Elihú Aranday-Cortés, Natasha Johnson, Igor Starinskij, Ana da Silva Filipe, David L. Robertson, Richard Orton, Joseph Hughes, Vattipally B. Sreenu, Joshua B. Singer, Seema Nickbakhsh, Antony Hale, Louissa Macfarlane-Smith, Katherine L. Harper, Holli Carden, Yusri Taha, Brendan Payne, Shirelle Burton-Fanning, Sheila Waugh, Jennifer Collins, Gary Eltringham, Steven Rushton, S. O’Brien, Amanda J. Bradley, Alasdair Maclean, Guy Mollett, Rachel Blacow, Kate Templeton, M. McHugh, Rebecca Dewar, Elizabeth Wastenge, Samir Dervisevic, Rachael Stanley, Emma Meader, Lindsay Coupland, Louise Smith, Clive Graham, Edward Barton, Debra Padgett, Garren Scott, Emma Swindells, Jane Greenaway, Andrew Nelson, Clare M. McCann, Wen C. Yew, Monique Andersson, Tim Peto, Anita Justice, David W. Eyre, Derrick W. Crook, Tim J. Sloan, Nichola Duckworth, Sarah Walsh, Anoop Chauhan, Sharon Glaysher, Kelly Bicknell, Sarah Wyllie, Scott Elliott, Allyson Lloyd, Robert Impey, Nick Levene, Lynn Monaghan, Declan Bradley, Tim Wyatt, Elias Allara, Clare Pearson, Husam Osman, Andrew Bosworth, Esther Robinson, Peter Muir, Ian B. Vipond, Richard Hopes, Hannah M. Pymont, Stephanie Hutchings, Martin D. Curran, Surendra Parmar, Angie Lackenby, Tamyo Mbisa, Shahjahan Miah, David Bibby, Carmen de Guerrero Manso, Jonathan Hubb, Gavin Dabrera, Mary Ramsay, Daniel Bradshaw, Alicia Thornton, Eileen Gallagher, David Lee, David A. Williams,
Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16-20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique ...
Nature Portfolio
Produção Nacional
Revisado por pares
João Paulo Barreto Sousa, José Carlos Tomaz, Cecília C. P. da Silva, Javier Ellena, Norberto Peporine Lopes, João Luís Callegari Lopes,
Two novel sesquiterpene lactones were isolated from crude extract of the Eremanthus seidelii leaves. Reliable structural elucidations to these lactones were established by 1D and 2D NMR spectroscopic techniques and high-resolution electrospray mass spectrometry data.
Tópico(s): Plant Toxicity and Pharmacological Properties
2012 - Elsevier BV | Tetrahedron Letters
Produção Nacional
Revisado por pares
Natalia Álvarez, Celisnólia M. Leite, Adriana Napoleone, Luís F.S. Mendes, Carlos Fernández-Ruiz, Ronny R. Ribeiro, Javier Ellena, Alzir A. Batista, Antonio J. Costa‐Filho, Gianella Facchin,
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2022 - Springer Science+Business Media | JBIC Journal of Biological Inorganic Chemistry
Produção Nacional
Revisado por pares
J. Sanchíz, Carlos Kremer, Marı́a H. Torre, Gianella Facchin, E. Kremer, E.E. Castellano, Javier Ellena,
A novel copper(II) complex containing the peptide phe-leu has been prepared and characterized. The crystal structure of [Cu(phe-leu)] (1) was determined by X-ray diffraction. The presence of carboxylate and amido bridges allows the formation of an extended 2D arrangement. This structure is similar to those found in [Cu(gly-val)] · 1/2H2O (2), [Cu(val-gly)] (3), [Cu(val-phe)] (4), and [Cu(phe-phe)] (5). The magnetic properties of compounds 1–5 were studied and analyzed comparatively. The experimental data show ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2006 - Elsevier BV | Journal of Molecular Structure