Produção Nacional
Revisado por pares
Gabriel Pereira Nunes, Alberto Carlos Botazzo Delbem, Jéssica Marcela de Luna Gomes, Cleidiel Aparecido Araújo Lemos, Eduardo Piza Pellizzer,
Tópico(s): Dental Radiography and Imaging
2021 - Springer Nature | Clinical Oral Investigations
Produção Nacional
Revisado por pares
Leonardo Bachá, Rodrigo Ventura, Maria Barrios, Jean de Aguiar Seabra, Diogo Tschoeke, Gizele D. Garcia, Bruno Pereira Masi, Larissa Macedo, José Marcus Godoy, Carlos Alberto Nunes Cosenza, Carlos Eduardo de Rezende, Vinícius Santos Lima, Adacto Benedicto Ottoni, Cristiane Thompson, Fabiano Thompson,
Tópico(s): Environmental Sustainability and Education
2021 - Springer Science+Business Media | Microbial Ecology
... aprofundar o estudo sobre hexâmetro dactílico vernáculo de Carlos Alberto Nunes”, observando 1) a exígua teoria do hexâmetro dactílico ...
Tópico(s): Linguistics and Language Studies
2014 - UNIVERSIDADE FEDERAL DO PARANÁ | Revista Letras
Produção Nacional
Revisado por pares
Patrícia Severino, Adriana Madeira Àlvares da Silva, Pedro Michaluart, Oswaldo Keith Okamoto, Fábio Daumas Nunes, Carlos Alberto Moreira‐Filho, Eloíza H. Tajara,
Oral squamous cell carcinoma (OSCC) is a frequent neoplasm, which is usually aggressive and has unpredictable biological behavior and unfavorable prognosis. The comprehension of the molecular basis of this variability should lead to the development of targeted therapies as well as to improvements in specificity and sensitivity of diagnosis. Samples of primary OSCCs and their corresponding surgical margins were obtained from male patients during surgery and their gene expression profiles were screened ...
Tópico(s): Head and Neck Cancer Studies
2008 - BioMed Central | BMC Research Notes
Produção Nacional
Revisado por pares
Fátima Cerqueira Alvim, Sônia M.B. Carolino, Júlio Cézar M. Cascardo, Cristiano Caixeta Nunes, Carlos Alberto Martínez, Wagner Campos Otoni, Elizabeth P. B. Fontes,
Abstract The binding protein (BiP) is an important component of endoplasmic reticulum stress response of cells. Despite extensive studies in cultured cells, a protective function of BiP against stress has not yet been demonstrated in whole multicellular organisms. Here, we have obtained transgenic tobacco (Nicotiana tabacum L. cv Havana) plants constitutively expressing elevated levels of BiP or its antisense cDNA to analyze the protective role of this endoplasmic reticulum lumenal stress protein ...
Tópico(s): Photosynthetic Processes and Mechanisms
2001 - Oxford University Press | PLANT PHYSIOLOGY
Francisco George, Tara Shivaji, Cátia Sousa Pinto, Luis Antonio Oliveira Serra, João Valente, Maria João Albuquerque, Paula Cristina Olivença Vicêncio, Ana San-Bento, Paulo Diegues, Paulo Nogueira, Teresa Marques, Helena Rebelo, Filipa Alves da Costa, Raquel Rodrigues, Alexandra Nunes, Vítor Borges, João Paulo Gomes, Daniel A. Sampaio, Paula Barreiro, Sílvia Duarte, Dina Carpinteiro, Joana Mendonça, Catarina Silva, Luı́s Vieira, Maria João Simões, Paulo Gonçalves, Baltazar Nunes, Carlos Alberto Dias, Jorge Machado, Fernando Antônio de Almeida, Elsa A Goncalves, M. Lucília Carvalho, Pedro Viterbo, Dília Jardim, Nuno Lacasta, Filomena Boavida, Ana Pérez, Isabel Santana, Paula Matias, Nuno Banza, C Rabaçal,
We describe the investigation and control of an outbreak of Legionnaires' disease in Portugal in October, November and December 2014. Confirmed cases were individuals with pneumonia, laboratory evidence of Legionella pneumophila serogroup 1 and exposure, by residence, occupational or leisure to the affected municipalities. 49 possible sources were reduced to four potential sources, all industries with wet cooling system, following risk assessment. We geo-referenced cases' residences and the location ...
Tópico(s): Dental Research and COVID-19
2016 - Elsevier BV | Revista Portuguesa de Saúde Pública
Produção Nacional
Revisado por pares
Natália Gedeão Salomão, Kíssila Rabelo, Tiago F. Póvoa, Ada M. B. Alves, Simone M. Costa, Antônio J. S. Gonçalves, Juliana Fernandes Amorim da Silva, Adriana de Souza Azevedo, Priscilla Conrado Guerra Nunes, Carlos Alberto Basílio‐de‐Oliveira, Rodrigo Basílio-de-Oliveira, Luiz Henrique Geraldo, Celina G. Fonseca, Flávia Regina Souza Lima, Ronaldo Mohana‐Borges, Emiliana M. Silva, Flávia Barreto dos Santos, Edson Oliveira, Marciano Viana Paes,
Dengue is a mild flu-like arboviral illness caused by dengue virus (DENV) that occurs in tropical and subtropical countries. An increasing number of reports have been indicating that dengue is also associated to neurological manifestations, however, little is known regarding the neuropathogenesis of the disease. Here, using BALB/c mice intravenously infected with DENV-2 strain 66985, we demonstrated that the virus is capable of invading and damaging the host's central nervous system (CNS). Brain and ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2018 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Flávia Maria Silva-Veiga, Tamiris Lima Rachid, Letícia de Oliveira, Francielle Graus‐Nunes, Carlos Alberto Mandarim‐de‐Lacerda, Vanessa Souza‐Mello,
Endoplasmic reticulum (ER) stress and hepatic steatosis are intertwined with insulin resistance. PPARs are at the crossroads of these pathways. This study aimed to investigate the effects of GW0742 (PPAR-beta agonist) on hepatic energy metabolism and ER stress in a murine diet-induced obesity model. HF diet caused overweight, hyperinsulinemia, hepatic inflammation (increased NF-kB, TNF-alpha, and IL-6 protein expression) and favored hepatic lipogenesis, leading to ER stress, with ultrastructural and ...
Tópico(s): Pancreatic function and diabetes
2018 - Elsevier BV | Molecular and Cellular Endocrinology
Guilherme Quinaz Romana, Irina Kislaya, Mário Rui Salvador, Susana Cunha Gonçalves, Baltazar Nunes, Carlos Alberto Dias,
Introduction: The simultaneous presence of multiple chronic diseases in the same individual is recognized as an important public health problem. Patients with multimorbidity have greater healthcare needs, which represents a higher burden on health services. Although there is no consensual definition of this concept, multimorbidity is usually defined as the presence of two or more chronic diseases in the same patient. The existence of evidence regarding multimorbidity will lead to more efficient ...
Tópico(s): Healthcare Systems and Reforms
2019 - Ordem dos Médicos | Acta Médica Portuguesa
Guilherme Quinaz Romana, Irina Kislaya, Mário Rui Salvador, Susana Cunha Gonçalves, Baltazar Nunes, Carlos Alberto Dias,
The simultaneous presence of multiple chronic diseases in the same individual is recognized as an important public health problem. Patients with multimorbidity have greater healthcare needs, which represents a higher burden on health services. Although there is no consensual definition of this concept, multimorbidity is usually defined as the presence of two or more chronic diseases in the same patient. The existence of evidence regarding multimorbidity will lead to more efficient management and ...
Tópico(s): Global Public Health Policies and Epidemiology
2019 - Ordem dos Médicos | Acta Médica Portuguesa
Produção Nacional
Revisado por pares
Danielle L. Ferreira, Bruno A. A. Nunes, Carlos Alberto V. Campos, Katia Obraczka,
Understanding human mobility plays a vital role in urban and environmental planning as cities continue to grow. Ubiquitous geo-location, localization technology, and availability of big-data-ready computing infrastructure have enabled the development of more sophisticated models to characterize human mobility in urban areas. In this work, our main goal is to extract spatio-temporal features that characterize user mobility and, based on the similarity of these features, identify user communities . ...
Tópico(s): Video Surveillance and Tracking Methods
2020 - Association for Computing Machinery | ACM Transactions on Spatial Algorithms and Systems
Produção Nacional
Revisado por pares
Marina Justi, Matheus P. Freitas, Josué M. Silla, Cleiton Antônio Nunes, Carlos Alberto Silva,
Tópico(s): Phytochemicals and Antioxidant Activities
2021 - Elsevier BV | Journal of Molecular Structure
Produção Nacional
Revisado por pares
Cristiane C. Thompson, Leonardo Bachá, Pedro Henrique C. Paz, Marcelo de Assis Passos Oliveira, Bráulio Cherene Vaz de Oliveira, Claudia Y. Omachi, Caroline Chueke, Marcela de Lima Hilário, Michele S. Lima, Luciana Leomil, Thais Felix-Cordeiro, Thalya Lou Cordeiro da Cruz, Koko Otsuki, Lívia Vidal, Mateus Thompson, Renan Ribeiro e Silva, Carlos Mauricio Vicuña Cabezas, Bruno Marque Veríssimo, José Luiz Zaganelli, Ana Caroline N. Botelho, Lúcia Martins Teixeira, Carlos Alberto Nunes Cosenza, Paulo Márcio Santos Costa, Felipe Schwahofer Landuci, Diogo Tschoeke, Tatiana Araújo Silva, Márcia Attias, Wanderley de Souza, Carlos Eduardo de Rezende, Fabiano L. Thompson,
Mollusc rearing is a relevant global socioeconomic activity. However, this activity has faced severe problems in the last years in southeast Brazil. The mariculture scallop production dropped from 51,2 tons in 2016 to 10,2 tons in 2022 in the Baia da Ilha Grande (BIG; Rio de Janeiro). However, the possible causes of this collapse are unknown. This study aimed to analyze decadal trends of water quality in Nodipecten nodosus spat and adult production in BIG. We also performed physical-chemical and ...
Tópico(s): Microplastics and Plastic Pollution
2023 - Elsevier BV | The Science of The Total Environment
Produção Nacional
Revisado por pares
Gabriel Pereira Nunes, Beatriz Ommati Pirovani, Larissa Pereira Nunes, Arles Naisa Amaral Silva, Maria Juliana Sismeiro Dias Morábito, Nilson Antônio Nunes-Júnior, Alberto Carlos Botazzo Delbem, Túlio Morandin Ferrisse,
Tópico(s): Oral and gingival health research
2022 - Springer Nature | Clinical Oral Investigations
Linda Sher, Carlos Alberto Nunes Cosenza, Jacques Michel, L Makowka, Charles M. Miller, Myron Schwartz, Ronald W. Busuttil, Sue V. McDiarmid, James F. Burdick, Andrew S. Klein, Carlos O. Esquivel, Göran B. Klintmalm, Marlon F. Levy, John P. Roberts, John R. Lake, Münci Kalayoğlu, Anthony M. D’Alessandro, Robert D. Gordon, Andrei C. Stieber, Byers W. Shaw, J. Richard Thistlethwaite, Peter F. Whittington, Russell H. Wiesner, Michael K. Porayko, J. S. Bynon, Devin E. Eckhoff, Richard B. Freeman, Richard J. Rohrer, W. David Lewis, J. Wallis Marsh, Marion G. Peters, John A. Powelson, A. Benedict Cosimi,
Background. A study was performed by 17 different U.S. liver transplantation centers to determine the safety and efficacy of conversion from cyclosporine to tacrolimus for chronic allograft rejection. Methods. Ninety-one patients were converted to tacrolimus a mean of 319 days after liver transplantation. The indication for conversion was ongoing chronic rejection confirmed by biochemical and histologic criteria. Patients were followed for a mean of 251 days until the end of the study. Results. ...
Tópico(s): Liver Disease and Transplantation
1997 - Wolters Kluwer | Transplantation
Produção Nacional
João Angelo Oliva Neto, Érico Nogueira,
... breve história do hexâmetro dactílico vernáculo antes de Carlos Alberto Nunes, é também e sobretudo reflexão sobre os princípios ... history of the dactylic hexameter in Portuguese before Carlos Alberto Nunes and a study of the metrical and prosodical ...
Tópico(s): Galician and Iberian cultural studies
2013 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Scientia Traductionis
Nicolas Jabbour, Sherin K. Shirazl, Yuri Genyk, Rod Mateo, Eddy Pak, Carlos Alberto Nunes Cosenza, Christian G. Peyré, Robert Selby,
Increased worldwide travel and immigration have led to an increase in the incidence of hepatic hydatid disease outside of endemic areas. In nonendemic areas lack of familiarity with the disease may lead to a delay in diagnosis with increased risk for development of complicated disease. Complicated disease is defined as: infected cysts, cysts with a hyperechoic solid pattern or calcified walls, or cysts with biliary rupture. Over a 6-month period six patients with complicated hydatid disease were ...
Tópico(s): Parasitic Infections and Diagnostics
2002 - SAGE Publishing | The American Surgeon
Haval Shirwan, Carlos Alberto Nunes Cosenza, HONG K. WANG, Guo‐Du Wu, L Makowka, Donald V. Cramer,
Brequinar sodium (BQR) is a new immunosuppressive drug that is highly effective in preventing graft rejection in several different experimental settings, including primary allografts and xenografts. A short course of BQR treatment during the onset of allograft rejection can induce the permanent survival of liver and kidney allografts in rats. To study the molecular basis of BQR-induced prolongation of allograft survival, we analyzed the intragraft pattern of IL-1 alpha, IL-2, IL-2R, IL-4, IL-6, IL- ...
Tópico(s): Renal Transplantation Outcomes and Treatments
1994 - Wolters Kluwer | Transplantation
Carlos Alberto Nunes Cosenza, Donald V. Cramer, Scott A. Cunneen, Phillip Tuso, HONG K. WANG, L Makowka,
Lipid peroxidation may play a major role in the loss of liver graft viability after prolonged cold ischemia and reperfusion injury. The lazaroid compound U74006F is a potent inhibitor of lipid peroxidation, and this study was designed to evaluate the efficacy of this compound in preventing cold ischemia–reperfusion damage in three different models: pig endothelial cells in culture, ex vivo isolated pig liver perfusion and orthotopic transplantation of syngeneic rat livers. The addition of U74006F ...
Tópico(s): Liver Disease and Transplantation
1994 - Lippincott Williams & Wilkins | Hepatology
Produção Nacional
Revisado por pares
Alberto José de Araújo, Jaime Lima, Josino Costa Moreira, Silvana do Couto Jacob, Mónica Soares, Marcos César Monassa Monteiro, Alexandre Muza do Amaral, Alexandre H. Kubota, Armando Meyer, Carlos Alberto Nunes Cosenza, César das Neves, Steven Markowitz,
Um estudo transversal foi realizado em uma comunidade agrícola localizada em Nova Friburgo, RJ, para conhecer os aspectos epidemiológicos, clínicos e laboratoriais da exposição múltipla a agrotóxicos em uma amostra representativa de 102 pequenos agricultores, de ambos os sexos. Os trabalhadores foram submetidos a um extenso protocolo que incluía aplicação de questionário ocupacional, coleta de amostras biológicas para exame toxicológico e avaliação clínica - geral e neurológica. Os resultados dos ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2007 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Moacyr Roberto Cucê Nobre, Otto Corrêa Rotunno Filho, W.J. Mansur, Moacyr Roberto Cucê Nobre, Carlos Alberto Nunes Cosenza,
A groundwater vulnerability and risk mapping assessment, based on a source–pathway–receptor approach, is presented for an urban coastal aquifer in northeastern Brazil. A modified version of the DRASTIC methodology was used to map the intrinsic and specific groundwater vulnerability of a 292 km2 study area. A fuzzy hierarchy methodology was adopted to evaluate the potential contaminant source index, including diffuse and point sources. Numerical modeling was performed for delineation of well capture ...
Tópico(s): Groundwater and Watershed Analysis
2007 - Elsevier BV | Journal of Contaminant Hydrology
Philip Tuso, Donald V. Cramer, Chikao Yasunaga, Carlos Alberto Nunes Cosenza, Guo Du Wu, L Makowka,
We have examined the nature of the binding of human xenoantibodies to pig liver and kidney vascular endothelium. Our results demonstrate that human serum contains IgM and IgG xenoantibodies that bind to pig vascular endothelium, and that the pattern of antibody binding is similar for both livers and kidneys. Immunohistochemical analysis of pig kidneys after perfusion with human blood demonstrated the binding of both IgM and IgG xenoantibodies, complement (C3), and fibrinogen to the vascular and glomerular ...
Tópico(s): Xenotransplantation and immune response
1993 - Wolters Kluwer | Transplantation
Phillip Tuso, D. V. Cramer, Yvette Middleton, Mary Kearns‐Jonker, Chikao Yasunaga, Carlos Alberto Nunes Cosenza, W C Davis, Guo-Guang Wu, L Makowka,
Human-to-pig xenoantibodies may constitute a major obstacle to the successful use of pigs as xenograft donors for human transplantation. Our studies demonstrate that normal human serum contains antibodies, primarily IgM, that are cytotoxic for pig aortic endothelial cells (PAECs). These antibodies bind to several antigens isolated from PAECs, lymphocytes, platelets, red blood cells, and the kidney. Absorption of human serum with pig lymphocytes removes the cytotoxic activity to PAECs and some, but ...
Tópico(s): Transplantation: Methods and Outcomes
1993 - Wolters Kluwer | Transplantation
Armen Kassabian, John P. Stein, Nicolas Jabbour, Kambiz Parsa, Donald G. Skinner, Dilip Parekh, Carlos Alberto Nunes Cosenza, Rick Selby,
Objectives. To present a series of 5 patients with solitary metastatic renal cell carcinoma (RCC) to the pancreas after radical nephrectomy at our institution and review the published reports of this rare event. Methods. A retrospective review of the records of 5 patients with histologically confirmed RCC metastatic to the pancreas after radical nephrectomy was performed. A total of 5 patients (4 men, 1 woman) with a median age of 56 years (range 54 to 68) underwent radical nephrectomy for primary ...
Tópico(s): Renal and related cancers
2000 - Elsevier BV | Urology
Produção Nacional
Revisado por pares
Cláudio Henrique dos Santos Grecco, Mário César Vidal, Carlos Alberto Nunes Cosenza, Isaac José Antônio Luquetti dos Santos, Paulo Victor Rodrigues de Carvalho,
Abstract Culture is a complex concept and this paper is devoted to improving the safety culture in safe-critical organizations. The culture of any organization in the international nuclear industry is centered on safety. This reflects human awareness and the recognition that strict attention to safety is essential if the benefits of this form of power are to be realized. For a nuclear organization safety culture is the dominant aspect of the organizational culture. Assessing the safety culture of ...
Tópico(s): Supply Chain Resilience and Risk Management
2013 - Elsevier BV | Progress in Nuclear Energy
Carlos Alberto Nunes Cosenza, Haval Shirwan, Donald V. Cramer, Linda Sher, Luis G. Podestá, L Makowka,
Cytokines are thought to play an important role in the inflammatory and immune responses of allograft rejection. We evaluated the pattern of cytokine gene expression in 36 liver biopsy specimens obtained from 20 recipients of primary orthotopic liver allografts. Specific mRNA expression was identified by a polymerase chain reaction (PCR) using oligonucleotide primers specific for human interleukin (IL)-1 beta, IL-2, IL-4, IL-6, IL-10 Interferon (IFN) gamma, tumor necrosis factor (TNF)-alpha and beta- ...
Tópico(s): Immune Response and Inflammation
1995 - Wiley | Liver Transplantation and Surgery
L Makowka, Donald V. Cramer, Allen Hoffman, Michael Breda, Linda Sher, G Eiras-Hreha, Philip Tuso, Chikao Yasunaga, Carlos Alberto Nunes Cosenza, Guo Du Wu, F Chapman, Luis G. Podestá,
A 26-year-old female patient with fulminant hepatic failure and a history of autoimmune hepatitis was heterotopically transplanted with a pig hepatic xenograft to provide temporary metabolic support prior to transplantation with a human donor organ. Circulating natural antipig antibodies were removed prior to transplantation by plasmapheresis and ex vivo en bloc perfusion of the donor pig kidneys. The liver xenograft functioned after transplantation as measured by active bile production, stabilization ...
Tópico(s): Liver Disease and Transplantation
1995 - Wolters Kluwer | Transplantation
Walid El Moudani, Carlos Alberto Nunes Cosenza, Marc de Coligny, Félix Mora-Camino,
In this communication a bi-criterion approach for the nominal Airlines Crew Rostering Problem is developed. The nominal Crew Rostering Problem considers the assignment of the crew staff to a set of pairings covering all the scheduled flights so that operations costs are minimized while its solution must meet hard constraints resulting from the safety regulations of Civil Aviation as well as from the airlines internal agreements. Another goal is of the highest interest for airlines: since the overall ...
Tópico(s): Optimization and Packing Problems
2001 - Springer Science+Business Media | Lecture notes in computer science
Carlos Alberto Nunes Cosenza, B Saffari, Nicolas Jabbour, Steven C. Stain, David Garry, Dilip Parekh, Robert Selby,
Biliopancreatic gallstone disorders (BPD) manifesting during pregnancy are relatively rare. The management of these conditions remains controversial. Although perioperative problems and fetal loss have been reported, recent publications have advocated an early surgical approach.Thirty-two pregnant women underwent operation for BPD between January 1993 and December 1997. The mean age was 29 years and ranged from 18 to 41 years.Twelve patients underwent a laparoscopic cholecystectomy (LC), and 20 open ...
Tópico(s): Hernia repair and management
1999 - Elsevier BV | The American Journal of Surgery
Carlos Alberto Nunes Cosenza, Linda Sher, Bernard J. Poletti, Donald Tschirhart, Hiroji Noguchi, Allen Hoffman, Richard R. Lopez, Diana Lugo, Sergio Rojter, L Makowka,
An 82-year-old black woman with a history of hepatocellular carcinoma presented with gastrointestinal bleeding. Barium enema and fibrocolonoscopy revealed a 4-cm polypoid mass at the level of the ascending colon with evidence of active bleeding. Biopsies of the lesion proved it to be metastatic hepatocellular carcinoma. Exploratory laparotomy revealed no further dissemination of the tumor, and the patient underwent an ileocolectomy. The serosal side of the colonic lesion was free from tumor, and ...
Tópico(s): Colorectal Cancer Treatments and Studies
1999 - SAGE Publishing | The American Surgeon