Sara Demain, Ana‐Carolina Gonçalves, Carlos Areia, Rúben Oliveira, Ana Jorge Marcos, Alda Marques, R Parmar, Katherine Hunt,
Background ‘Treatment burden’, defined as both the workload and impact of treatment regimens on function and well-being, has been associated with poor adherence and unfavourable outcomes. Previous research focused on treatment workload but our understanding of treatment impact is limited. This research aimed to systematically review qualitative research to identify: 1) what are the treatment generated disruptions experienced by patients across all chronic conditions and treatments? 2) what strategies ...
Tópico(s): Family Caregiving in Mental Illness
2015 - Public Library of Science | PLoS ONE
Carlos Areia, Louise Young, Sarah Vollam, Jody Ede, Mauro Santos, Lionel Tarassenko, Peter Watkinson,
Timely recognition of patient deterioration remains challenging. Ambulatory monitoring systems (AMSs) may provide support to current monitoring practices; however, they need to be thoroughly tested before implementation in the clinical environment for early detection of deterioration.The objective of this study was to assess the wearability of a selection of commercially available AMSs to inform a future prospective study of ambulatory vital sign monitors in an acute hospital ward.Five pulse oximeters ( ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2020 - JMIR Publications | JMIR mhealth and uhealth
Daniel R. Morales, Mitchell M. Conover, Seng Chan You, Nicole Pratt, Kristin Kostka, Talita Duarte‐Salles, Sergio Fernández‐Bertolín, María Aragón, Scott L. DuVall, Kristine E. Lynch, Thomas Falconer, Kees van Bochove, Cynthia Sung, Michael E. Matheny, Christophe G Lambert, Fredrik Nyberg, Thamir M. Alshammari, Andrew E. Williams, Rae Woong Park, James Weaver, Anthony G. Sena, Martijn J. Schuemie, Peter R. Rijnbeek, Ross D. Williams, Jennifer C. E. Lane, Albert Prats‐Uribe, Lin Zhang, Carlos Areia, Harlan M. Krumholz, Daniel Prieto‐Alhambra, Patrick Ryan, George Hripcsak, Marc A. Suchard,
SummaryBackgroundAngiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been postulated to affect susceptibility to COVID-19. Observational studies so far have lacked rigorous ascertainment adjustment and international generalisability. We aimed to determine whether use of ACEIs or ARBs is associated with an increased susceptibility to COVID-19 in patients with hypertension.MethodsIn this international, open science, cohort analysis, we used electronic health ...
Tópico(s): Hormonal Regulation and Hypertension
2020 - Elsevier BV | The Lancet Digital Health
Produção Nacional
Revisado por pares
Jennifer C. E. Lane, James Weaver, Kristin Kostka, Talita Duarte‐Salles, Maria Tereza Fernandes Abrahão, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, Carlos Areia, Patricia Biedermann, Juan M. Banda, Edward Burn, Paula Casajust, Kristina Fišter, Jill Hardin, Laura Hester, George Hripcsak, Benjamin Skov Kaas‐Hansen, Sajan Khosla, Spyros Kolovos, Kristine E. Lynch, Rupa Makadia, Paras Mehta, Daniel R. Morales, Henry Morgan-Stewart, Mees Mosseveld, Danielle Newby, Fredrik Nyberg, Anna Ostropolets, Rae Woong Park, Albert Prats‐Uribe, Gowtham Rao, Christian Reich, Peter R. Rijnbeek, Anthony G. Sena, Azza Shoaibi, Henry M. Spotnitz, Vignesh Subbian, Marc A. Suchard, David Vizcaya, Haini Wen, Marcel de Wilde, Junqing Xie, Seng Chan You, Lin Zhang, Simon Lovestone, Patrick Ryan, Daniel Prieto‐Alhambra,
Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used in the coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with HCQ as used for RA.
Tópico(s): Drug-Induced Ocular Toxicity
2020 - Oxford University Press | Lara D. Veeken
Produção Nacional
Revisado por pares
Edward Burn, Seng Chan You, Anthony G. Sena, Kristin Kostka, Hamed Abedtash, Maria Tereza Fernandes Abrahão, Amanda Alberga, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, María Aragón, Carlos Areia, Juan M. Banda, Jaehyeong Cho, Aedín C. Culhane, Alexander Davydov, Frank DeFalco, Talita Duarte‐Salles, Scott L. DuVall, Thomas Falconer, Sergio Fernández‐Bertolín, Weihua Gao, Asieh Golozar, Jill Hardin, George Hripcsak, Vojtech Huser, Hokyun Jeon, Yonghua Jing, Chi Young Jung, Benjamin Skov Kaas‐Hansen, Denys Kaduk, Seamus Kent, Yeesuk Kim, Spyros Kolovos, Jennifer C. E. Lane, Hyejin Lee, Kristine E. Lynch, Rupa Makadia, Michael E. Matheny, Paras Mehta, Daniel R. Morales, Karthik Natarajan, Fredrik Nyberg, Anna Ostropolets, Rae Woong Park, Jimyung Park, Jose Posada, Albert Prats‐Uribe, Gowtham Rao, Christian Reich, Yeunsook Rho, Peter R. Rijnbeek, Lisa M. Schilling, Martijn J. Schuemie, Nigam H. Shah, Azza Shoaibi, Seok Young Song, Henry M. Spotnitz, Marc A. Suchard, Joel N. Swerdel, David Vizcaya, Salvatore Volpe, Haini Wen, Andrew E. Williams, Belay Birlie Yimer, Lin Zhang, Oleg Zhuk, Daniel Prieto‐Alhambra, Patrick Ryan,
Abstract Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients ...
Tópico(s): COVID-19 epidemiological studies
2020 - Nature Portfolio | Nature Communications
Loretta Davies, Jonathan Cook, José Leal, Carlos Areia, Beverly A. Shirkey, William F. Jackson, Helen Campbell, Heidi Fletcher, Andrew Carr, Karen Barker, Sarah E Lamb, A. Paul Monk, Sean O’Leary, Fares S. Haddad, Chris Wilson, Andrew Price, David Beard,
Abstract Background Anterior cruciate ligament (ACL) rupture is a common knee injury that can lead to poor quality of life, decreased activity and increased risk of secondary osteoarthritis of the knee. Management of patients with a non-acute ACL injury can include a non-surgical (rehabilitation) or surgical (reconstruction) approach. However, insufficient evidence to guide treatment selection has led to high variation in treatment choice for patients with non-acute presentation of ACL injury. The ...
Tópico(s): Orthopedic Surgery and Rehabilitation
2020 - Springer Science+Business Media | Trials
Produção Nacional
Revisado por pares
Jenna Reps, Chungsoo Kim, Ross D. Williams, Aniek F. Markus, Cynthia Yang, Talita Duarte‐Salles, Thomas Falconer, Jitendra Jonnagaddala, Andrew E. Williams, Sergio Fernández‐Bertolín, Scott L. DuVall, Kristin Kostka, Gowtham Rao, Azza Shoaibi, Anna Ostropolets, Henry M. Spotnitz, Lin Zhang, Paula Casajust, Ewout W. Steyerberg, Fredrik Nyberg, Benjamin Skov Kaas‐Hansen, Young Hwa Choi, Daniel R. Morales, Siaw‐Teng Liaw, Maria Tereza Fernandes Abrahão, Carlos Areia, Michael E. Matheny, Kristine E. Lynch, María Aragón, Rae Woong Park, George Hripcsak, Christian Reich, Marc A. Suchard, Seng Chan You, Patrick Ryan, Daniel Prieto‐Alhambra, Peter R. Rijnbeek,
Background SARS-CoV-2 is straining health care systems globally. The burden on hospitals during the pandemic could be reduced by implementing prediction models that can discriminate patients who require hospitalization from those who do not. The COVID-19 vulnerability (C-19) index, a model that predicts which patients will be admitted to hospital for treatment of pneumonia or pneumonia proxies, has been developed and proposed as a valuable tool for decision-making during the pandemic. However, the ...
Tópico(s): COVID-19 epidemiological studies
2021 - JMIR Publications | JMIR Medical Informatics
Mauro Santos, Sarah Vollam, Marco A. F. Pimentel, Carlos Areia, Louise Young, Cristian Román, Jody Ede, Philippa Piper, Elizabeth King, Mirae Harford, Akshay Shah, Owen Gustafson, Lionel Tarassenko, Peter Watkinson,
Commercially available wearable (ambulatory) pulse oximeters have been recommended as a method for managing patients at risk of physiological deterioration, such as active patients with COVID-19 disease receiving care in hospital isolation rooms; however, their reliability in usual hospital settings is not known.We report the performance of wearable pulse oximeters in a simulated clinical setting when challenged by motion and low levels of arterial blood oxygen saturation (SaO2).The performance of ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2021 - JMIR Publications | Journal of Medical Internet Research
Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson, Sarah Vollam,
Abstract Background Timely recognition of the deteriorating inpatient remains challenging. Wearable monitoring systems (WMS) may augment current monitoring practices. However, there are many barriers to implementation in the hospital environment, and evidence describing the clinical impact of WMS on deterioration detection and patient outcome remains unclear. Objective To assess the impact of vital-sign monitoring on detection of deterioration and related clinical outcomes in hospitalised patients ...
Tópico(s): Cardiac Arrest and Resuscitation
2021 - BioMed Central | Critical Care
Martina Recalde, Elena Roel, Andrea Pistillo, Anthony G. Sena, Albert Prats‐Uribe, Waheed‐Ul‐Rahman Ahmed, Heba Alghoul, Thamir M. Alshammari, Osaid Alser, Carlos Areia, Edward Burn, Paula Casajust, Dalia Dawoud, Scott L. DuVall, Thomas Falconer, Sergio Fernández‐Bertolín, Asieh Golozar, Mengchun Gong, Lana Yin Hui Lai, Jennifer C. E. Lane, Kristine E. Lynch, Michael E. Matheny, Paras Mehta, Daniel R. Morales, Karthik Natarjan, Fredrik Nyberg, Jose Posada, Christian Reich, Peter R. Rijnbeek, Lisa M. Schilling, Karishma Shah, Nigam H. Shah, Vignesh Subbian, Lin Zhang, Hong Zhu, Patrick Ryan, Daniel Prieto‐Alhambra, Kristin Kostka, Talita Duarte‐Salles,
Abstract Background A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity. Methods We conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Springer Nature | International Journal of Obesity
Mauro Santos, Cristian Román, Marco A. F. Pimentel, Sarah Vollam, Carlos Areia, Louise Young, Peter Watkinson, Lionel Tarassenko,
The challenges presented by the Coronavirus disease 2019 (COVID-19) pandemic to the National Health Service (NHS) in the United Kingdom (UK) led to a rapid adaptation of infection disease protocols in-hospital. In this paper we report on the optimisation of our wearable ambulatory monitoring system (AMS) to monitor COVID-19 patients on isolation wards. A wearable chest patch (VitalPatch®, VitalConnect, United States of America, USA) and finger-worn pulse oximeter (WristOx2® 3150, Nonin, USA) were used ...
Tópico(s): COVID-19 diagnosis using AI
2021 - Frontiers Media | Frontiers in Digital Health
Talita Duarte‐Salles, David Vizcaya, Andrea Pistillo, Paula Casajust, Anthony G. Sena, Lana Yin Hui Lai, Albert Prats‐Uribe, Waheed‐Ul‐Rahman Ahmed, Thamir M. Alshammari, Heba Alghoul, Osaid Alser, Edward Burn, Seng Chan You, Carlos Areia, Clair Blacketer, Scott L. DuVall, Thomas Falconer, Sergio Fernández‐Bertolín, Stephen Fortin, Asieh Golozar, Mengchun Gong, Eng Hooi Tan, Vojtech Huser, Pablo Iveli, Daniel R. Morales, Fredrik Nyberg, Jose Posada, Martina Recalde, Elena Roel, Lisa M. Schilling, Nigam H. Shah, Karishma Shah, Marc A. Suchard, Lin Zhang, Ying Zhang, Andrew E. Williams, Christian Reich, George Hripcsak, Peter R. Rijnbeek, Patrick Ryan, Kristin Kostka, Daniel Prieto‐Alhambra,
OBJECTIVES To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017–2018. METHODS International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - American Academy of Pediatrics | PEDIATRICS
Eng Hooi Tan, Anthony G. Sena, Albert Prats‐Uribe, Seng Chan You, Waheed‐Ul‐Rahman Ahmed, Kristin Kostka, Christian Reich, Scott L. DuVall, Kristine E. Lynch, Michael E. Matheny, Talita Duarte‐Salles, Sergio Fernández‐Bertolín, George Hripcsak, Karthik Natarajan, Thomas Falconer, Henry M. Spotnitz, Anna Ostropolets, Clair Blacketer, Thamir M. Alshammari, Heba Alghoul, Osaid Alser, Jennifer C. E. Lane, Dalia Dawoud, Karishma Shah, Yue Yang, Lin Zhang, Carlos Areia, Asieh Golozar, Martina Recalde, Paula Casajust, Jitendra Jonnagaddala, Vignesh Subbian, David Vizcaya, Lana Yin Hui Lai, Fredrik Nyberg, Daniel R. Morales, Jose Posada, Nigam H. Shah, Mengchun Gong, Arani Vivekanantham, Aaron Abend, Evan Minty, Marc A. Suchard, Peter R. Rijnbeek, Patrick Ryan, Daniel Prieto‐Alhambra,
Patients with autoimmune diseases were advised to shield to avoid coronavirus disease 2019 (COVID-19), but information on their prognosis is lacking. We characterized 30-day outcomes and mortality after hospitalization with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza.
Tópico(s): SARS-CoV-2 and COVID-19 Research
2021 - Oxford University Press | Lara D. Veeken
Carlos Areia, Elizabeth King, Jody Ede, Louise Young, Lionel Tarassenko, Peter Watkinson, Sarah Vollam,
To understand current experiences of vital signs monitoring of patients and clinical staff on a surgical ward, and views on the introduction of wearable ambulatory monitoring into the general ward environment.Qualitative study.Semi-structured interviews using topic guides were conducted with 15 patients and 15 nurses on a surgical ward between July 2018 and August 2019. The concept of ambulatory wearable devices for clinical monitoring was introduced at the end of the interview.Three interconnected ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2021 - Wiley | Journal of Advanced Nursing
Carlos Areia, Mauro Santos, Sarah Vollam, Marco A. F. Pimentel, Louise Young, Cristian Román, Jody Ede, Philippa Piper, Elizabeth King, Owen Gustafson, Mirae Harford, Akshay Shah, Lionel Tarassenko, Peter Watkinson,
The standard of care in general wards includes periodic manual measurements, with the data entered into track-and-trigger charts, either on paper or electronically. Wearable devices may support health care staff, improve patient safety, and promote early deterioration detection in the interval between periodic measurements. However, regulatory standards for ambulatory cardiac monitors estimating heart rate (HR) and respiratory rate (RR) do not specify performance criteria during patient movement or ...
Tópico(s): Heart Rate Variability and Autonomic Control
2021 - JMIR Publications | Journal of Medical Internet Research
Produção Nacional
Revisado por pares
Ross D. Williams, Aniek F. Markus, Cynthia Yang, Talita Duarte‐Salles, Scott L. DuVall, Thomas Falconer, Jitendra Jonnagaddala, Chungsoo Kim, Yeunsook Rho, Andrew E. Williams, Amanda Alberga Machado, Min Ho An, María Aragón, Carlos Areia, Edward Burn, Young Hwa Choi, Iannis Drakos, Maria Tereza Fernandes Abrahão, Sergio Fernández‐Bertolín, George Hripcsak, Benjamin Skov Kaas‐Hansen, Prasanna L. Kandukuri, Jan A. Kors, Kristin Kostka, Siaw‐Teng Liaw, Kristine E. Lynch, Gerardo Machnicki, Michael E. Matheny, Daniel R. Morales, Fredrik Nyberg, Rae Woong Park, Albert Prats‐Uribe, Nicole Pratt, Gowtham Rao, Christian Reich, Marcela Rivera, Tom M Seinen, Azza Shoaibi, Henry M. Spotnitz, Ewout W. Steyerberg, Marc A. Suchard, Seng Chan You, Lin Zhang, Lili Zhou, Patrick Ryan, Daniel Prieto‐Alhambra, Jenna Reps, Peter R. Rijnbeek,
Abstract Background We investigated whether we could use influenza data to develop prediction models for COVID-19 to increase the speed at which prediction models can reliably be developed and validated early in a pandemic. We developed COVID-19 Estimated Risk (COVER) scores that quantify a patient’s risk of hospital admission with pneumonia (COVER-H), hospitalization with pneumonia requiring intensive services or death (COVER-I), or fatality (COVER-F) in the 30-days following COVID-19 diagnosis using ...
Tópico(s): Machine Learning in Healthcare
2022 - BioMed Central | BMC Medical Research Methodology
David Beard, Loretta Davies, Jonathan Cook, Jamie R. Stokes, José Leal, Heidi Fletcher, Simon Abram, Katie Chegwin, Akiko Greshon, William F. Jackson, Nicholas Bottomley, Matt Dodd, Henry Bourke, Beverly A. Shirkey, Arsenio Páez, Sarah E Lamb, Karen Barker, Michael Phillips, Mark T. Brown, Vanessa Lythe, Burhan Mirza, Andrew Carr, A. Paul Monk, Carlos Areia, Sean O’Leary, Fares S. Haddad, Chris Wilson, Andrew Price, Richard Emsley, George Peat, Martyn Snow, Marion Campbell, Tessa Howell, Hilary Johnson, Stephen McDonnell, Thomas Pinkney, Mark R. Williams, Helen Campbell, Jackie Davies, Jiyang Li, C. Bagg, Laura Haywood, Anne Nicholson, Joanne Riches, Sean Symons, Mark Vertue, Louay Al Mouazzen, Rachel Bray, Damian Clark, James Coulthard, T. J. B. Holland, Nick Howells, Andrew K. Jones, Richard Kapur, Alastair Kiszely, Harry Krishnan, Karen MacDonald-Taylor, Jon Manara, James L. Murray, Corina Negrut, Vishai Pai, Andrew Porteous, Sven Putnis, James L. Robinson, S.N. Rupasinghe, Veenesh Selvaratnam, James Q. Smith, Nicholas G. Smith, Jarrad Stevens, Clare Taylor, Anthony Theodorides, Niraj Vetharajan, Helen Vint, Lucy H. Young, Susan Bullock, Rebecca Cook, Alexander L. Dodds, Amanda Freeman-Hicks, Paula Hillout, Thomas Cornell, Abbie Coutts, Suzy Dean, Nicki Devooght-Johnson, Emma Ferrell, Eve Fletcher, C. R. Hall, Benjamin Kent, Sandra Kessly, Robin Kincaid, Mohamed Lazizi, Ahmed Mostafa, Toby Nisbett, Timothy J. Powell, P Riddlestone, Andrew Roberton, Jessica J. Summers, Lucy Whitbread, Belinda Wroath, Emma Fenlon, Andy Hall, Helen Jeffrey, Raghuram Thonse, Debra Dunne, Andrew Metcalfe, Kerri McGowan, Simon Middleton, Feisal Shah, Tim Spalding, Charlie Marie Suddens, Tamar Sweed, Joanna Teuke, Peter M. Thompson, David Wright, Justine Amero, Emma Brown, Hugh Chissell, Andrea Croucher, Gareth Dickinson, Catherine Hawkes-Blackburn, Alice Peacocke, G. P. Smith, Carol Snipe, Kim Dearnley, Reza Mayahi, B. Andrews, Massimo Barcelona, Hazel Giles, Abdulkerim Gokturk, Paul R. Harnett, Katie Jeeves, Joyce Kadunyi, Sheena Mendoza, Ines Reichert, M López Santamaría, Harshinder Virdee, Sanjeev Anand, Nayef Aslam-Pervez, Stephen Draycott, Faye Howarth, Irfan Jina, Niall Maher, Denise Ross, Lindsey Worstenholme, Abdul Mannan Baig, Arun Bhaskaran, Daniel Banks, Tracy Brear, C. Christie, Laura Cowen, Jack Davis, Ross Dixey, Colin Esler, Amirah Essop-Adam, Christina Haines, Linzy Houchen‐Wolloff, Husein Varachia, Richard T. A. Wood, Glaxy Gray, Jessica E. Nichols, Alice Panes, Susan Partridge, L. Rogerson, Pankaj Sharma, David Triggs, Ian Venables, Danielle Wilcock, Sarah Buckley, Thelma Darian, Elizabeth Denis, J. M. Bunn and G. A. Duncan, Charlotte Hirst, James Newman, Fern Richardson, J. Gustav Smith, Megan Adcode, Megan Cottingham, Eliza Foster, Andrew Kelly, Niamh McKay, J Rewbury, Alison Whitcher, James Williams, Esther Zebracki, Llinos Davies, Jayadeep Jayachandran, Alison Tardivel, Victoria Whitehead, M. Batting, Amy Bond, Marc Deakin, Christopher Dodd, Alison Hudak, Samantha Hynes, Luke D. Jones, Gail Lang, David S. McKenna, Susan Morris, Clare Scott-Dempster, Adam Sykes, Iason Vichos, Simon M. Wood, R. Clifton, Stephanie Diaz, Craig Hendy, Nishil Modi, Brendan M. O’Mahony, Susan O'Sullivan, Nicola Parker, Mira Pecheva, Rowan Rumonovic, Emma McLoughlin, Jeremy Rushbrook, Anna Thornhill, Valerie Parkinson, Rafael Sales, Katja Van De Snepscheut-Jones, D.J. Wilcock, Daniel R. Wright, Joanna Allison, Simon Baker, Kate Beesley, Gill Ferrari, B.J.A. Lankester, Alison Lewis, Joanne Lyons, Jamie O’Callaghan, Sarah Sutcliffe, Dianne Wood, Emily Bannister, Chloë Brown, Debbie Burden, Terence J. Campbell, Emma Craig, Rashmi Easow, Julie Foxton, Alexandra Hazlerigg, Chethan Jayabev, Rosie Murdoch, Georgie Parsons, Harry Brown, Paula Carvelli, Rugaia Montaser, A R Pepper, Sinduja Sivarajan, Oliver Templeton-Ward, Eva Wilson, Julie Cronin, Sarah Diment, Victoria King, Katharine Shean, Leonidas Vachtsevanos, Katharine Wilcocks, Ben Wilson, Paul McNestry, Joanna Ollerenshaw, James E. Stoddard, Paul Sutton, Sanjay Anand, Judith A. Bell, Albert Chikate, Diane Daniel, Timothy Davies, Tom Finnigan, Antonio Frasquet-Garcia, Susan Hopkins, Sharon Kerrison, Angela McGowan, David S. Johnson, Lara Smith, P.G. Turner, Helen Wilkinson, Lynne Allsop, Deborah Anthony, Rebecca L. Boulton, Sarah Brown, Vikram Desai, Mandy Gill, Cheryl Heeley, Sushrut Kulkarni, Wayne Lovegrove, Dominic Nash, Terri Ann Sewell, Sarah Shelton, Katie Slack, James E. Cartwright, Lynda Connor, Andrew Davies, Caroline Davies, Glyn Gainard, Dave Graham-Woollard, Carl Murphy, Leanne Quinn, Caradog Thomas, Jenny Travers, Marie Williams, Amanda Bell,
Anterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients with a non-acute ACL injury and persistent symptoms of instability.We did a pragmatic, multicentre, superiority, randomised controlled trial in 29 secondary care National Health Service orthopaedic units in the UK. Patients with symptomatic knee problems (instability) ...
Elsevier BV
Kristin Kostka, Talita Duarte‐Salles, Albert Prats‐Uribe, Anthony G. Sena, Andrea Pistillo, Sara Khalid, Lana Yin Hui Lai, Asieh Golozar, Thamir M. Alshammari, Dalia Dawoud, Fredrik Nyberg, Adam B. Wilcox, Alan Andryc, Andrew E. Williams, Anna Ostropolets, Carlos Areia, Chi Young Jung, Christopher A. Harle, Christian Reich, Clair Blacketer, Daniel R. Morales, David A. Dorr, Edward Burn, Elena Roel, Eng Hooi Tan, Evan Minty, Frank DeFalco, Gabriel de Maeztu, Gigi Lipori, Heba Alghoul, Hong Zhu, Jason Thomas, Jiang Bian, Jimyung Park, Jordi Martínez Roldán, Jose Posada, Juan M. Banda, Juan Pablo Horcajada, Julianna Kohler, Karishma Shah, Karthik Natarajan, Kristine E. Lynch, Li Liu, Lisa M. Schilling, Martina Recalde, Henry M. Spotnitz, Mengchun Gong, Michael E. Matheny, Neus Valveny, Nicole G. Weiskopf, Nigam H. Shah, Osaid Alser, Paula Casajust, Rae Woong Park, Robert Schuff, Sarah Seager, Scott L. DuVall, Seng Chan You, Seok Young Song, Sergio Fernández‐Bertolín, Stephen Fortin, Tanja Magoč, Thomas Falconer, Vignesh Subbian, Vojtech Huser, Waheed‐Ul‐Rahman Ahmed, William Carter, Yin Guan, Yankuic Galvan, Xing He, Peter R. Rijnbeek, George Hripcsak, Patrick Ryan, Marc A. Suchard, Daniel Prieto‐Alhambra,
Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response. Here we present the international Observational Health Data Sciences and Informatics (OHDSI) Characterizing Health Associated Risks and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation and analysis of COVID-19 RWD.
Tópico(s): Machine Learning in Healthcare
2022 - Dove Medical Press | Clinical Epidemiology
Laura C. Armitage, Chi Yuan, Mauro Santos, Beth K. Lawson, Carlos Areia, Carmelo Velardo, Peter Watkinson, Lionel Tarassenko, Matthew L. Costa, Andrew Farmer,
Abstract Background Hip fracture is common, affecting 20% of women and 10% of men during their lifetime. The trajectory of patients’ recovery as they transition from the acute hospital setting to their usual residence is poorly understood. Recently, the use of activity trackers to monitor physical activity during recovery has been investigated as a way to explore this trajectory. Methods This prospective observational cohort study followed patients from hospital to home as they recovered from a ...
Tópico(s): Trauma and Emergency Care Studies
2020 - BioMed Central | Pilot and Feasibility Studies
Xintong Li, Lana Yin Hui Lai, Anna Ostropolets, Faaizah Arshad, Eng Hooi Tan, Paula Casajust, Thamir M. Alshammari, Talita Duarte‐Salles, Evan Minty, Carlos Areia, Nicole Pratt, Patrick Ryan, George Hripcsak, Marc A. Suchard, Martijn J. Schuemie, Daniel Prieto‐Alhambra,
Using real-world data and past vaccination data, we conducted a large-scale experiment to quantify bias, precision and timeliness of different study designs to estimate historical background (expected) compared to post-vaccination (observed) rates of safety events for several vaccines. We used negative (not causally related) and positive control outcomes. The latter were synthetically generated true safety signals with incident rate ratios ranging from 1.5 to 4. Observed vs. expected analysis using ...
Tópico(s): COVID-19 epidemiological studies
2021 - Frontiers Media | Frontiers in Pharmacology
Lana Yin Hui Lai, Faaizah Arshad, Carlos Areia, Thamir M. Alshammari, Heba Alghoul, Paula Casajust, Xintong Li, Dalia Dawoud, Fredrik Nyberg, Nicole Pratt, George Hripcsak, Marc A. Suchard, Daniel Prieto‐Alhambra, Patrick Ryan, Martijn J. Schuemie,
Post-marketing vaccine safety surveillance aims to detect adverse events following immunization in a population. Whether certain methods of surveillance are more precise and unbiased in generating safety signals is unclear. Here, we synthesized information from existing literature to provide an overview of the strengths, weaknesses, and clinical applications of epidemiologic and analytical methods used in vaccine monitoring, focusing on cohort, case-control and self-controlled designs. These designs ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2022 - Frontiers Media | Frontiers in Pharmacology
Carlos Areia, Sarah Vollam, Philippa Piper, Elizabeth King, Jody Ede, Louise Young, Mauro Santos, Marco A. F. Pimentel, Cristian Román, Mirae Harford, Akshay Shah, Owen Gustafson, Matthew Rowland, Lionel Tarassenko, Peter Watkinson,
Introduction Automated continuous ambulatory monitoring may provide an alternative to intermittent manual vital signs monitoring. This has the potential to improve frequency of measurements, timely escalation of care and patient safety. However, a major barrier to the implementation of these wearable devices in the ward environment is their uncertain reliability, efficiency and data fidelity. The purpose of this study is to test performance of selected devices in a simulated clinical setting including ...
Tópico(s): Autopsy Techniques and Outcomes
2020 - BMJ | BMJ Open
Carlen Reyes, Andrea Pistillo, Sergio Fernández‐Bertolín, Martina Recalde, Elena Roel, Diana Puente, Anthony G. Sena, Clair Blacketer, Lana Yin Hui Lai, Thamir M. Alshammari, Waheed-UI-Rahman Ahmed, Osaid Alser, Heba Alghoul, Carlos Areia, Dalia Dawoud, Albert Prats‐Uribe, Neus Valveny, Gabriel de Maeztu, Luisa Sorlí Redó, Jordi Martínez Roldán, Inmaculada López-Montesinos, Lisa M. Schilling, Asieh Golozar, Christian Reich, Jose Posada, Nigam H. Shah, Seng Chan You, Kristine E. Lynch, Scott L. DuVall, Michael E. Matheny, Fredrik Nyberg, Anna Ostropolets, George Hripcsak, Peter R. Rijnbeek, Marc A. Suchard, Patrick Ryan, Kristin Kostka, Talita Duarte‐Salles,
To characterise patients with and without prevalent hypertension and COVID-19 and to assess adverse outcomes in both inpatients and outpatients.
Tópico(s): COVID-19 and healthcare impacts
2021 - BMJ | BMJ Open
Carlos Areia, Paulo Barreira, Tiago Montanha, José Oliveira, Fernando Ribeiro,
Impact of prior injury on myoelectrical activity of the hamstrings during isokinetic eccentric contractions has received increased literature attention. This cross-sectional study aimed to assess neuromuscular adaptations, namely proprioception, core stability, muscle strength, extensibility and activity, in football players with history of hamstring strain injury.Seventeen players, 10 with history of hamstring injury and 7 without prior injury underwent isokinetic strength testing, eccentric knee ...
Tópico(s): Cardiovascular Effects of Exercise
2019 - Elsevier BV | Clinical Biomechanics
Elena Roel, Andrea Pistillo, Martina Recalde, Anthony G. Sena, Sergio Fernández‐Bertolín, María Aragón, Diana Puente, Waheed‐Ul‐Rahman Ahmed, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, Carlos Areia, Clair Blacketer, William Carter, Paula Casajust, Aedín C. Culhane, Dalia Dawoud, Frank DeFalco, Scott L. DuVall, Thomas Falconer, Asieh Golozar, Mengchun Gong, Laura Hester, George Hripcsak, Eng Hooi Tan, Hokyun Jeon, Jitendra Jonnagaddala, Lana Yin Hui Lai, Kristine E. Lynch, Michael E. Matheny, Daniel R. Morales, Karthik Natarajan, Fredrik Nyberg, Anna Ostropolets, Jose Posada, Albert Prats‐Uribe, Christian Reich, Donna R. Rivera, Lisa M. Schilling, Isabelle Soerjomataram, Karishma Shah, Nigam H. Shah, Yang Shen, Matthew Spotniz, Vignesh Subbian, Marc A. Suchard, Annalisa Trama, Lin Zhang, Ying Zhang, Patrick Ryan, Daniel Prieto‐Alhambra, Kristin Kostka, Talita Duarte‐Salles,
Abstract Background: We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and coronavirus disease 2019 (COVID-19). Second, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza. Methods: We conducted a cohort study using eight routinely collected health care databases from Spain and the United States, standardized to the Observational Medical Outcome Partnership common ...
Tópico(s): Economic and Financial Impacts of Cancer
2021 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Giorgio Gandaglia, Francesco Pellegrino, Asieh Golozar, Bertrand De Meulder, Thomas Abbott, Ariel H. Achtman, Muhammad Imran Omar, Thamir M. Alshammari, Carlos Areia, Alex Asiimwe, Katharina Beyer, Anders Bjartell, Riccardo Campi, Philip Cornford, Thomas Falconer, Qi Feng, Mengchun Gong, Ronald Herrera, Nigel Hughes, Tim Hulsen, Adam Kinnaird, Lana Yin Hui Lai, Gianluca Maresca, Nicolas Mottet, Marek Oja, Peter Prinsen, Christian Reich, Sebastiaan Remmers, Monique J. Roobol, Vasileios Sakalis, Sarah Seager, Emma Jane Smith, Robert Snijder, Carl Steinbeißer, Nicolas H. Thurin, Ayman Hijazy, Kees van Bochove, Roderick C.N. van den Bergh, Mieke Van Hemelrijck, Peter-Paul Willemse, Andrew E. Williams, Nazanin Zounemat Kermani, Susan Evans‐Axelsson, Alberto Briganti, James N’Dow,
Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through the application of big data analytics. To describe the clinical characteristics and long-term outcomes of PCa patients on conservative management by using an international large network ...
Tópico(s): Colorectal Cancer Screening and Detection
2023 - Elsevier BV | European Urology
Ahmed Saeed Younis, Ibrahim Mahmoud Abdelmonem, Moheeb Gadullah, Hamdy E Alnaggar, Yasser R Mohamed, Gemma Villanueva, Jacqueline Thompson, Carlos Areia, Ashraf Nabhan,
Background Donor site wounds of split‐thickness skin grafts can be a major cause of morbidity. Choosing the appropriate dressing for these wounds is crucial to successful healing. Various types of dressing are available, including hydrogel dressings. A review of current evidence is required to guide clinical decision‐making on the choice of dressing for the treatment of donor sites of split‐thickness skin grafts. Objectives To assess the effects of hydrogel dressings on donor site wounds following ...
Tópico(s): Planarian Biology and Electrostimulation
2023 - Elsevier BV | Cochrane library
Olga P. Nyssen, Ángeles Pérez‐Aísa, Bojan Tepeš, Manuel Castro‐Fernández, Juozas Kupčinskas, Laimas Virginijus Jonaitis, Luís Bujanda, Alfredo J. Lucendo, Nataša Brglez Jurečič, Jorge Pérez-Lasala, Oleg Shvets, Galina Fadeenko, José María Huguet, Zdenki Kikec, Д.С. Бордин, Irina Voynovan, Mārcis Leja, José Carlos Machado, Miguel Areia, Luís Fernández-Salazar, Luı́s Rodrigo, С. А. Алексеенко, Jesus Barrio, Juan Ortuño, Mónica Perona, Л. Г. Вологжанина, Pilar Mata Romero, O V Zaytsev, Theodore Rokkas, Sotirios D. Georgopoulos, Rinaldo Pellicano, György Miklós Buzás, Inés Modolell, Blas José Gómez Rodríguez, İlkay Şımşek, Cem Şimşek, Marina Roldan Lafuente, Tatiana Ilchishina, Judith Gómez Camarero, Manuel Domínguez‐Cajal, Vassiliki Ntouli, Н. Н. Дехнич, Perminder Phull, Óscar Núñez Martínez, Frode Lerang, Marino Venerito, Frédéric Heluwaert, Ante Tonkić, María Caldas, Ignasi Puig, Françis Mégraud, C O'Morain, Javier P. Gisbert,
INTRODUCTION: The safety of Helicobacter pylori eradication treatments and to what extent adverse events (AEs) influence therapeutic compliance in clinical practice are hardly known. Our aim was to assess the frequency, type, intensity, and duration of AEs, and their impact on compliance, for the most frequently used treatments in the “European Registry on Helicobacter pylori management.” METHODS: Systematic prospective noninterventional registry of the clinical practice of European gastroenterologists ( ...
Tópico(s): Gastric Cancer Management and Outcomes
2021 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Daniel R. Morales, Anna Ostropolets, Lana Yin Hui Lai, Anthony G. Sena, Scott L. DuVall, Marc A. Suchard, Katia Verhamme, Peter Rjinbeek, Joe Posada, Waheed‐Ul‐Rahman Ahmed, Thamer Alshammary, Heba Alghoul, Osaid Alser, Carlos Areia, Clair Blacketer, Edward Burn, Paula Casajust, Seng Chan You, Dalia Dawoud, Asieh Golozar, Menchung Gong, Jitendra Jonnagaddala, Kristine E. Lynch, Michael E. Matheny, Evan Minty, Fredrik Nyberg, Albert Prats‐Uribe, Martina Recalde, Christian Reich, Martijn Scheumie, Karishma Shah, Nigam H. Shah, Lisa M. Schilling, David Vizcaya, Lin Zhang, George Hripcsak, Patrick Ryan, Daniel Prieto‐Alhambra, Talita Durate-Salles, Kristin Kostka,
Objective: Large international comparisons describing the clinical characteristics of patients with COVID-19 are limited. The aim of the study was to perform a large-scale descriptive characterization of COVID-19 patients with asthma.Methods: We included nine databases contributing data from January to June 2020 from the US, South Korea (KR), Spain, UK and the Netherlands. We defined two cohorts of COVID-19 patients ('diagnosed' and 'hospitalized') based on COVID-19 disease codes. We followed patients ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2022 - Taylor & Francis | Journal of Asthma
Mirae Harford, Carlos Areia, Mauricio Villarroel, João Jorge, Eoin Finnegan, Shaun Davidson, Adam Mahdi, Duncan Young, Lionel Tarassenko, Peter Watkinson,
Introduction Skin perfusion varies in response to changes in the circulatory status. Blood flow to skin is reduced during haemodynamic collapse secondary to peripheral vasoconstriction, whereas increased skin perfusion is frequently observed when haemodynamics improve with resuscitation. These changes in perfusion may be monitored using non-contact image-based methods. Previous camera-derived physiological measurements have focused on accurate vital signs monitoring and extraction of physiological ...
Tópico(s): Heart Rate Variability and Autonomic Control
2020 - BMJ | BMJ Open