Produção Nacional
Revisado por pares
Sreekanth Thota, Daniel A. Rodrigues, Pedro de Sena Murteira Pinheiro, Lı́dia Moreira Lima, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro,
Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and future challenges in the emergence of bioactive NAH-based scaffolds and to developing strategies to overcome the failures in drug discovery. The NAH-related approved drugs nitrofurazone, nitrofurantoin, carbazochrome, testosterone 17-enanthate 3-benzilic acid hydrazine, nifuroxazide, dantrolene, and azumolene are already ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2018 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Produção Nacional
Revisado por pares
Raul Hernandes Bortolin, Bento João Abreu, Marcela Abbott Galvão Ururahy, Karla Simone Costa de Souza, João Felipe Bezerra, Melina Bezerra Loureiro, Flávio Santos da Silva, Dáfiny Emanuele da Silva Marques, Angélica Amanda de Sousa Batista, Gisele Viana de Oliveira, André Ducati Luchessi, Valéria Morgiana Gualberto Duarte Moreira Lima, Carlos Eduardo Saraiva Miranda, Marcus Vinícius Lia Fook, Maria das Graças Almeida, Luciana Augusto de Rezende, Adriana Augusto de Rezende,
Several studies have established an association between diabetes and alterations in bone metabolism; however, the underlying mechanism is not well established. Although zinc is recognized as a potential preventive agent against diabetes-induced bone loss, there is no evidence demonstrating its effect in chronic diabetic conditions. This study evaluated the effects of zinc supplementation in a chronic (90 days) type 1 diabetes-induced bone-loss model. Male Wistar rats were distributed in three groups: ...
Tópico(s): Bone Metabolism and Diseases
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Lı́dia Moreira Lima, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro,
A DRUG: THALIDOMIDE.Thalidomide, first synthesized in 1953, was widely prescribed for morning sickness of pregnant women from 1957 to 1961, when it was found to be seriously teratogenic, having caused serious birth defect.Nowadays, a quarter of a century later, it appears that it may be a miracle drug for such diseases as leprosy, AIDS, cancer and tuberculosis.
Tópico(s): Male Reproductive Health Studies
2001 - Brazilian Chemical Society | Química Nova
Produção Nacional
Jose-Henrique Alves, Eric Oliveira Ribeiro, Guisela Santiago Grossmann Matheson, José Antônio Moreira Lima, Carlos Eduardo Parente Ribeiro,
Uma reconstituição dos campos de onda pretéritos no oceano Atlântico Sul foi realizada pelo modelo de ondas WAVEWATCH III onde testes foram feitos para determinar as configurações das grades numéricas mais adequadas para o estudo e para a verificação e calibração da qualidade dos ventos e forçantes selecionadas para a elaboração do hindcast dos campos de onda. Em relação aos campos de vento do modelo observou-se valores subestimados abaixo de 7, 5 m/s e superestimados acima de 7, 5 m/s, quando comparados ...
Tópico(s): Ocean Waves and Remote Sensing
2009 - Brazilian Society of Geophysics | Brazilian Journal of Geophysics
Produção Nacional
Revisado por pares
Gilberto M. Sperandio da Silva, Lı́dia Moreira Lima, Carlos Alberto Manssour Fraga, Carlos Maurício R. Sant’Anna, Eliezer J. Barreiro,
In this work, we present the results of two combined approaches, molecular docking and comparative molecular field analysis (CoMFA), to propose how the selective cyclooxygenase-2 inhibitor celecoxib could act as a p38 mitogen-activated protein (MAP) kinase inhibitor. The docking analysis revealed why celecoxib has a less favorable binding energy (ΔG = −12.4 kcal/mol) than the selective p38 MAP kinase (p38 MAPK) inhibitor, SB203580 (ΔG = −22.2 kcal/mol). The CoMFA results revealed unfavorable steric effects ...
Tópico(s): Synthesis and biological activity
2005 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Produção Nacional
Revisado por pares
Nelilma Correia Romeiro, Carlos Maurício R. Sant’Anna, Lı́dia Moreira Lima, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro,
This paper describes molecular docking studies of a series of classical NSAIDs with PPARgamma receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been found to be responsible for some of the already established pharmacological effects observed for marketed drugs. The results show the molecular basis of PPARgamma activation by non-selective COX inhibitors.
Tópico(s): Eicosanoids and Hypertension Pharmacology
2008 - Elsevier BV | European Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Modesto Leite Rolim Neto, Hiure Gomes Almeida, Joana D’arc Esmeraldo, Camila Bezerra Nobre, Woneska Rodrigues Pinheiro, Cícera Rejane Tavares de Oliveira, Itamara da Costa Sousa, Onélia Maria Moreira Leite Lima, Nádia Nara Rolim Lima, Marcial Moreno Moreira, Carlos Kennedy Tavares Lima, Jucier Gonçalves Júnior, Claúdio Gleideston Lima da Silva,
: The fact that COVID-19 is transmissible from human to human and associated with high morbidity and potentially fatality can intensify the perception of personal danger. In addition, the foreseeable shortage of supplies and an increasing flow of suspected and real cases of COVID-19 contribute to the pressures and concerns of health professionals. : The studies were identified in well-known international journals found in two electronic databases: Scopus and Embase. The data were cross-checked with information ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Elsevier BV | Psychiatry Research
Produção Nacional
Revisado por pares
Anderson Nogueira Mendes, Lívia Alves Filgueiras, Mônica Siqueira, Gleyce Moreno Barbosa, Carla Holandino, Davyson Moreira de Lima, José Carlos Pinto, Márcio Nele,
This study aimed to synthesize and characterize nanoparticles (NPs) of poly(methyl methacrylate) (PMMA) and evaluate their ability to incorporate plant extracts with antitumor activity and low dissolution in aqueous media. The extract used was n-hexane partition of the methanol extract of Piper cabralanum (PCA-HEX). PMMA NPs were obtained using the mini-emulsion method, which was able to encapsulate almost 100% of PCA-HEX. The synthesized polymeric particles presented with a size of 200 nm and a negative ...
Tópico(s): Multicomponent Synthesis of Heterocycles
2017 - Dove Medical Press | International Journal of Nanomedicine
António L. Maçanita, Paulo F. Moreira, João Carlos Lima, Frank H. Quina, Chang Yihwa, Carolina Vautier-Giongo,
A new method for the determination of proton-transfer rate constants in the ground state of anthocyanins and related flavylium salts is described. The method is based on the well-known pKa shift of phenols on going from ground to the first excited singlet state coupled to the typically very fast excited state proton transfer and very short lifetimes (picosecond range) occurring in these compounds. Under these conditions, a nanosecond light pulse instantaneously shifts the ground-state equilibrium, ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2002 - American Chemical Society | The Journal of Physical Chemistry A
Carolina Vautier-Giongo, Chang Yihwa, Paulo F. Moreira, João Carlos Lima, Adilson A. Freitas, Marilene Alves, Frank H. Quina, António L. Maçanita,
The effects of anionic, cationic, and nonionic micelles on the dynamics of proton transfer in the ground and excited state of anthocyanins have been examined employing the 4-methyl-7-hydroxyflavylium ion (HMF) as a model compound. Unlike other anthocyanins and anthocyanin analogues, HMF does not hydrate in water, allowing study of the acid−base (AH+/A) equilibrium in the absence of competing hydration or tautomerism reactions. Anionic sodium dodecyl sulfate (SDS) micelles are found to stabilize the ...
Tópico(s): Phytochemicals and Antioxidant Activities
2002 - American Chemical Society | Langmuir
Produção Nacional
Revisado por pares
Juliana Figueiredo Peixoto, Ygor Jessé Ramos, Davyson de Lima Moreira, Carlos Roberto Alves, Luiz Filipe Gonçalves-Oliveira,
Tópico(s): Research on Leishmaniasis Studies
2021 - Springer Science+Business Media | Parasitology Research
Produção Nacional
Revisado por pares
Raniella Falchetto Bazoni, Carlos Henrique Moreira Lima, Érica Ramos, M. S. Rocha,
By using optical tweezers with an adjustable trap stiffness, we have performed systematic single molecule stretching experiments with two types of DNA–intercalator complexes, in order to investigate the effects of the maximum applied forces on the mechanical response of such complexes.
Tópico(s): Advanced biosensing and bioanalysis techniques
2015 - Royal Society of Chemistry | Soft Matter
Produção Nacional
Revisado por pares
Hélio Pereira Lopes, Edson Jorge Lima Moreira, Carlos Nelson Elias, Renata Andriola de Almeida, Mônica Schultz Neves,
The present work evaluated the influence of the curved segment length of artificial root canals (the arc) and the number of cycles necessary to fracture engine-driven nickel-titanium endodontic instruments. ProTaper F3 25-mm files at 250 rpm were used in two artificial canals. The artificial canals were made of stainless steel with an inner diameter of 1.04 mm, a total length of 20 mm, and arc on the ends with a radius of curvature of 6 mm. The arc length of the first tube measured 9.4 mm, and the ...
Tópico(s): Dental materials and restorations
2006 - Elsevier BV | Journal of Endodontics
Produção Nacional
Revisado por pares
Flávia Afonso Lima, Carlos Alberto Moreira‐Filho, Patrícia Locosque Ramos, Helena Brentani, Leandro de A. Lima, Magaly Arrais dos Santos, Luiz C. Bento-de-Souza, Luciana Bento‐de‐Souza, Maria Irma Seixas Duarte, António Coutinho, Magda Carneiro‐Sampaio,
The Down syndrome (DS) immune phenotype is characterized by thymus hypotrophy, higher propensity to organ-specific autoimmune disorders, and higher susceptibility to infections, among other features. Considering that AIRE (autoimmune regulator) is located on 21q22.3, we analyzed protein and gene expression in surgically removed thymuses from 14 DS patients with congenital heart defects, who were compared with 42 age-matched controls with heart anomaly as an isolated malformation. Immunohistochemistry ...
Tópico(s): Adrenal Hormones and Disorders
2011 - American Association of Immunologists | The Journal of Immunology
Produção Nacional
Revisado por pares
Maria Letícia de Castro Barbosa, Lı́dia Moreira Lima, Roberta Tesch, Carlos Maurício R. Sant’Anna, Frank Totzke, Michael H.G. Kubbutat, Christoph Schächtele, Stefan Laufer, Eliezer J. Barreiro,
Novel 2-chloro-4-anilino-quinazolines designed as EGFR and VEGFR-2 dual inhibitors were synthesized and evaluated for inhibitory effects. EGFR and VEGFR-2 are validated targets in cancer therapy and combined inhibition might be synergistic for both antitumor activity and resistance prevention. The biological data obtained proved the potential of 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors, highlighting compound 8o, which was approximately 7-fold more potent on ...
Tópico(s): Synthesis of Tetrazole Derivatives
2013 - Elsevier BV | European Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Bruno C. Públio, Tiago Moura, Carlos Henrique Moreira Lima, M. S. Rocha,
We have performed a biophysical characterization, at single molecule level, of the interaction between the DNA molecule and the biogenic polyamine putrescine. By using force spectroscopy, we were able to monitor the complexes formation as putrescine is added to the sample, determining the mechanical properties of such complexes and the physicochemical (binding) parameters of the interaction for three different ionic strengths. In particular, it was shown that the behavior of the equilibrium binding ...
Tópico(s): Bacteriophages and microbial interactions
2018 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Carlos Henrique Moreira Lima, G.O. Almeida, M. S. Rocha,
We report a high cooperative transition from the semi-flexible to the flexible regime of polymer elasticity during the interaction of the DNA molecule with the chemotherapeutic drug Mitoxantrone (MTX). By using single molecule force spectroscopy, we show that the force-extension curves of the DNA-MTX complexes deviate from the typical worm-like chain behavior as the MTX concentration in the sample increases, becoming straight lines for sufficiently high drug concentrations. The behavior of the radius ...
Tópico(s): Nanopore and Nanochannel Transport Studies
2018 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Produção Nacional
Revisado por pares
Débora E.S. Silva, Mariana P. Cali, Wallance Moreira Pazin, Estêvão Carlos-Lima, M. Trevisan, Tiago Venâncio, Manoel Arcisio‐Miranda, Amando Siuiti Ito, Rose Maria Carlos,
The complexes cis-[Ru(phen)2(Apy)2]2+, Apy = 4-aminopyridine and 3,4-aminopyridine, are stable in aqueous solution with strong visible absorption. They present emission in the visible region with long lifetime that accumulates in the cytoplasm of Neuro2A cell line without appreciable cytotoxicity. The complexes also serve as mixed-type reversible inhibitors of human AChE and BuChE with high active site contact. cis-[Ru(phen)2(3,4Apy)2]2+ competes efficiently with DMPO by the OH• radical. Luminescence ...
Tópico(s): Molecular Sensors and Ion Detection
2016 - American Chemical Society | Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Juliana Pereira Lyon, Conceição de Maria Pedroso e Silva Azevedo, Leonardo Marmo Moreira, Carlos José de Lima, Maria Aparecida de Resende,
Tópico(s): Ocular Infections and Treatments
2011 - Springer Science+Business Media | Mycopathologia
Produção Nacional
Revisado por pares
Michal Ramalho, J. M. Garcia, César Roberto Esper, Roberta Vantini, Beatriz da Costa Aguiar Alves, IM Almeida, Vera Fernanda Martins Hossepian de Lima, Carlos Alberto Moreira‐Filho,
Murine and bovine embryos at the late morula stage were cultured in medium containing high-titer rat H-Y antisera. After 12 h of incubation, embryos blocked at the late morulae stage were classified as males and those at the blastocyst stage were classified as females. Sexing of murine embryos by PCR and cytogenetics revealed that 83% of the embryos classified as males and 82% of those classified as females had their sex correctly predicted (P < 0.05). Bovine embryos were transferred to recipient females. ...
Tópico(s): Reproductive Biology and Fertility
2004 - Elsevier BV | Theriogenology
Produção Nacional
Brunnella Alcântara Chagas de Freitas, Luciana Moreira Lima, Carla Fernanda Lisboa Valente Carlos, Silvia Eloíza Priore, Sylvia do Carmo Castro Franceschini,
Identify and analyze variables associated with shorter duration of breastfeeding in preterm infants. Retrospective cohort of premature infants followed up at secondary referral service in the period of 2010–2015. Inclusion: first appointment in the first month of corrected age and have undergone three or more consultations. Exclusion: diseases that impaired oral feeding. Outcome: duration of breastfeeding. A total of 103 preterm infants were evaluated, accounting for 28.8% of the preterm infants ...
Tópico(s): Infant Nutrition and Health
2016 - Elsevier BV | Revista Paulista de Pediatria (English Edition)
Produção Nacional
Revisado por pares
Brunnella Alcântara Chagas de Freitas, Luciana Moreira Lima, Carla Fernanda Lisboa Valente Carlos, Silvia Eloíza Priore, Sylvia do Carmo Castro Franceschini,
Identify and analyze variables associated with shorter duration of breastfeeding in preterm infants.Retrospective cohort of premature infants followed up at secondary referral service in the period of 2010-2015.first appointment in the first month of corrected age and have undergone three or more consultations. Exclusion: diseases that impaired oral feeding.duration of breastfeeding. A total of 103 preterm infants were evaluated, accounting for 28.8% of the preterm infants born in the municipality ...
Tópico(s): Infant Development and Preterm Care
2015 - Elsevier BV | Revista Paulista de Pediatria
Produção Nacional
Revisado por pares
Vera Fernanda Martins Hossepian de Lima, Carlos Alberto Moreira‐Filho, A.R. De, W. Jorge,
Murine and bovine embryos were sexed by using polyclonal and monoclonal anti-H-Y antibodies in cytotoxic and immunofluorescence assays. The specificity of 3 different sources of antibodies are compared. Sexing was accomplished by complement-mediated cytotoxicity or by H-Y antigen detection using a anti-mouse Ig fluorescein conjugate. Cytogenetic ascertainment for correct sex identification yielded a score of about 85% in both species, while the immunofluorescence assay yielded a score of 83%.
Tópico(s): CRISPR and Genetic Engineering
1993 - Elsevier BV | Theriogenology
Produção Nacional
Revisado por pares
Lı́dia Moreira Lima, Carlos Alberto Manssour Fraga, Vera Lúcia Gonçalves Koatz, Eliezer J. Barreiro,
Thalidomide ([2-(2,6-dioxo-hexahydro-3-(R,S)-pyridinyl)-1,3-isoindolinedione]), well known by its teratogenic effect, caused birth defects in up to 12,000 children in the 1960s. More recently, this drug was approved by the US Food and Drug Administration for the treatment of erythema nodosum leprosum, under restricted-use program, and a variety of new possible therapeutic applications have been described. This article will accomplish a review of medicinal chemistry aspects of thalidomide and state ...
Tópico(s): Cancer therapeutics and mechanisms
2006 - Bentham Science Publishers | Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Produção Nacional
Revisado por pares
Lı́dia Moreira Lima, Cláudia B. Ormelli, Carlos Alberto Manssour Fraga, Ana Luísa P. Miranda, Eliezer J. Barreiro,
As part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring Brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). The new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. The anti-aggregating activity of these ...
Tópico(s): Synthesis and Reactivity of Sulfur-Containing Compounds
1999 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Revisado por pares
Jucier Gonçalves Júnior, Jair Paulino de Sales, Marcial Moreno Moreira, Carlos Kennedy Tavares Lima, Modesto Leite Rolim Neto,
OPINION article Front. Psychiatry, 30 October 2020Sec. Public Mental Health Volume 11 - 2020 | https://doi.org/10.3389/fpsyt.2020.570439
Tópico(s): Mental Health Treatment and Access
2020 - Frontiers Media | Frontiers in Psychiatry
Produção Nacional
Revisado por pares
Eliane Patrícia Lino Pereira-Franchi, Maria Rachel Nogueira Barreira, Natália de Sousa Lima Moreira da Costa, Carlos Magno Castelo Branco Fortaleza, Maria de Lourdes Ribeiro de Souza da Cunha,
Wounds can be colonized by methicillin-resistant Staphylococcus aureus (MRSA).We evaluated the prevalence of S. aureus and MRSA in the wounds of patients treated at Basic Health Units in Brazil and identified risk factors associated with their presence.The prevalence rates of S. aureus and MRSA were 51.5% and 8.7%, respectively. There was a correlation between the presence of S. aureus in wounds and nostrils (p<0.01). A positive association was detected between S. aureus infection and previous benzylpenicillin ...
Tópico(s): Surgical site infection prevention
2017 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Arthur Costa de Souza, Fernando C. Melo, Thales Lima Oliveira, Carlos Eduardo Moreira Tavares,
In many research centers around the world, had been researched models that accurately represent the PV modules operation. In this context, this paper presents a modeling of photovoltaic modules, which aims to simplify the simulation of photovoltaic systems in MATLAB ® /Simulink. The model in question has not been very explored in the literature and, therefore, this paper has the purpose of evaluating its results connecting the model to a boost converter, being its main function the Maximum Power Point ...
Tópico(s): solar cell performance optimization
2016 - Institute of Electrical and Electronics Engineers | IEEE Latin America Transactions
Produção Nacional
Lamartine Moreira Lima David, Carlos Dias Chaym,
O presente estudo teve como objetivo identificar as principais causas da evasão em instituições de ensino superior e construir uma escala de satisfação de graduandos. Foi aplicado um questionário em um total de 498 respondentes pertencentes ao corpo discente, selecionados pelo critério de acessibilidade. A escala construída foi submetida à análise fatorial, resultando em uma estrutura composta por 68 itens distribuídos pelos fatores: F1 (professor), F2 (projeto pedagógico), F3 (infraestrutura), F4 ( ...
Tópico(s): Academic Research in Diverse Fields
2019 - Faculdade Meridional IMED | Revista de Administração IMED
Produção Nacional
Revisado por pares
Danilo Yamamoto Thomaz, João Nóbrega de Almeida, Gláucia Moreira Espíndola Lima, Maína de Oliveira Nunes, Carlos Henrique Camargo, Rafaella de Carvalho Grenfell, Gil Benard, Gilda Maria Bárbaro Del Negro,
The incidence of candidemia by the Candida parapsilosis complex has increased considerably in recent decades, frequently related to use of indwelling intravascular catheters. The ability of this pathogen to colonize healthcare workers (HCW)' hands, and to form biofilm on medical devices has been associated with the occurrence of nosocomial outbreaks and high mortality rates. Fluconazole has been the leading antifungal drug for the treatment of invasive candidiasis in developing countries. However, ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2018 - Frontiers Media | Frontiers in Microbiology