David V.C. Brito, Filipa Esteves, Ana Teresa Rajado, Nádia Silva, Rossana M. C. Andrade, Joana Apolónio, Sofia M. Calado, Maria Leonor Faleiro, Carlos A. Matos, Nuno Marques, Ana Marreiros, Hipólito Nzwalo, Sandra Pais, Isabel Palmeirim, Vânia Palma Roberto, Sónia Simão, Natércia Joaquim, Rubén Miranda, António Pêgas, D. Raposo, Attilio Di Spiezio Sardo, Inês M. Araújo, José Bragança, Pedro Castelo‐Branco, Clévio Nóbrega,
Abstract As life expectancy continues to increase worldwide, age-related dysfunction will largely impact our societies in the future. Aging is well established to promote the deterioration of cognitive function and is the primary risk factor for the development of prevalent neurological disorders. Even in the absence of dementia, age-related cognitive decline impacts specific types of memories and brain structures in humans and animal models. Despite this, preclinical and clinical studies that investigate ...
Tópico(s): Diet and metabolism studies
2023 - | npj Aging
Nádia Silva, Ana Teresa Rajado, Filipa Esteves, David V.C. Brito, Joana Apolónio, Vânia Palma Roberto, Alexandra Binnie, Inês M. Araújo, Clévio Nóbrega, José Bragança, Pedro Castelo‐Branco, Raquel P. Andrade, Sofia M. Calado, Maria Leonor Faleiro, Carlos A. Matos, Nuno Marques, Ana Marreiros, Hipólito Nzwalo, Sandra Pais, Isabel Palmeirim, Sónia Simão, Natércia Joaquim, Rui Gonçalves Miranda, António Pêgas, Ana Paula Sardo,
Abstract Human ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and healthcare resources, there is a growing need to identify reliable and easy-to-employ markers of healthy ageing for early detection of ageing trajectories and disease risk. Such markers would allow for the targeted implementation of strategies ...
Tópico(s): Health, Environment, Cognitive Aging
2023 - Springer Science+Business Media | Biogerontology
Maria Luı́s Amorim, Carlos Vasconcelos, Duarte C. Oliveira, Ana Azevedo, Elsa Calado, Nuno A. Faria, Marta Pereira, Ana Castro, Alice T. Campos Moreira, Ernestina Aires, José Manuel Cabeda, Maria Helena Ramos, José Manuel Amorim, Hermı́nia de Lencastre,
This two-year study investigated the epidemiology of nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) among patients and healthcare workers (HCWs) in two wards with a high frequency of MRSA isolation, at Hospital Geral de Santo António (HGSA), Portugal. Three point-prevalence surveys per year were carried out. A case-control approach was used to identify potential risk factors associated with MRSA carriage among patients. Incidence rates and risk factors of MRSA carriage among ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2009 - Mary Ann Liebert, Inc. | Microbial Drug Resistance
Filipa Esteves, David V.C. Brito, Ana Teresa Rajado, Nádia Silva, Joana Apolónio, Vânia Palma Roberto, Inês M. Araújo, Clévio Nóbrega, Pedro Castelo‐Branco, José Bragança, Raquel P. Andrade, Sofia M. Calado, Maria Leonor Faleiro, Carlos A. Matos, Nuno Marques, Ana Marreiros, Hipólito Nzwalo, Sandra Pais, Isabel Palmeirim, Sónia Simão, Natércia Joaquim, Rui Miranda, António Pêgas, D. Raposo, Ana Paula Sardo,
The unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in the scientific and medical research communities to develop and improve therapies to delay ageing and age-associated functional decline and diseases, and to expand health span. The establishment of induced pluripotent stem cells (iPSCs) by reprogramming ...
Tópico(s): 3D Printing in Biomedical Research
2023 - Elsevier BV | Mechanisms of Ageing and Development
Maria Luı́s Amorim, Nuno A. Faria, Duarte C. Oliveira, Carlos Vasconcelos, José Manuel Cabeda, Ana Constança Mendes, Elsa Calado, Ana Castro, Maria Helena Ramos, José Manuel Amorim, Hermı́nia de Lencastre,
ABSTRACT Two hundred eighty methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates recovered from a tertiary care hospital in Oporto, Portugal, between 2003 and 2005 were studied by a combination of molecular typing techniques in order to investigate the genetic backgrounds associated with the changes in the resistance phenotypes observed since 2001 and compare them to those previously found in the hospital. All MRSA isolates were grouped into resistance profiles for a panel of seven ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2007 - American Society for Microbiology | Journal of Clinical Microbiology
Michael Hoskin, Oriol Mercadal Fernández, Sara Aliaga i Rodrigo, Luix Mari Zaldua, Antón A. Rodríguez Casal, Nuno Miguel Soares, María Socorro López Plaza, João Carlos Senna-Martínez, Francisco Henriques, Juan Antonio Belmonte, Miguel Lago, Joāo Albergaria, Manuel Calado, Andrea Martins,
Cet article presente les resultats de travaux sur le terrain conduits au cours des annees 90 dans la plupart des regions de la Peninsule riches en tombes megalithiques. Les auteurs s'attachent dans cette etude a inventorier les donnees qu'ils ont recueillies, se reservant de les interpreter dans une etude ulterieure.
Tópico(s): Archaeological and Historical Studies
1998 - SAGE Publishing | Journal for the History of Astronomy
Bruno Boto Calado, Samir M. Ahmad, Carlos Almeida, Nuno R. Neng, J.M.F. Nogueira,
Bar adsorptive microextraction (BAµE), using selective sorbent phases, followed by liquid desorption in combination with large volume injection-gas chromatography coupled to mass spectrometry (BAµE-LD/LVI-GC-MS), is proposed for the determination of trace levels of irgarol in estuarine water matrices. While we compared several polymers and activated carbons, one of the latter coatings showed much higher selectivity through BAµE. Assays performed on 25 mL of ultra-pure water sample fortified at 0.6 ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2016 - Oxford University Press | Journal of Chromatographic Science
Cheila Rocha, Rita Calado, Pedro Borrego, José Maria Marcelino, Inês Bártolo, Lino Rosado, Patrícia Cavaco‐Silva, Perpétua Gómes, Carlos Família, Alexandre Quintas, Helena Skar, Thomas Leitner, Helena Barroso, Nuno Taveira,
Abstract Background Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4 + T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and resulting HIV-2 escape during acute infection and their impact in HIV-2 evolution ...
Tópico(s): T-cell and B-cell Immunology
2013 - BioMed Central | Retrovirology
Filipa Esteves, David V.C. Brito, Ana Teresa Rajado, Nádia Silva, Joana Apolónio, Vânia Palma Roberto, Raquel P. Andrade, Sofia M. Calado, Maria Leonor Faleiro, Carlos A. Matos, Nuno Marques, Ana Marreiros, Hipólito Nzwalo, Sandra Pais, Isabel Palmeirim, Sónia Simãoa, Natércia Joaquim, Rui Miranda, António Pêgas, D. Raposo, Ana Paula Sardo, Inês M. Araújo, Clévio Nóbrega, Pedro Castelo‐Branco, José Bragança,
Human induced pluripotent stem cells (hiPSCs) hold promises to model and understand human diseases, including those associated with ageing. Here, we describe ABCRIi001-A, a hiPSC line generated from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female enrolled in a study for development of an ageing score (ALFA Score). PBMCs were reprogrammed using three Sendai virus-based reprogramming vectors (hKOS, hc-Myc, and hKlf4). ABCRIi001-A showed normal morphology and karyotype, viral clearance, ...
Tópico(s): 3D Printing in Biomedical Research
2024 - Elsevier BV | Stem Cell Research
Teresa Temudo, M. Paula Souza Dos Santos, Karin Ziliotto Dias, Ana Moreira, JP Vieira, G Olivieira, E Calado, Clara Barbot, A Lévy, Inês Carrilho, M. A. S. Fonseca, Agenor Dias, Nuno Lobo Antunes, Pedro Cabral, J Perdra Monteiro, Regina Lúcia Elia Gomes, Carlos César Barbosa, Gabriela Andrada,
Objectives: Rett syndrome (RS) was discovered by Andreas Rett, when he noticed that two girls who were waiting for his consultation presented the same movement disorder: hand stereotypies. Hand stereotypies are the hallmark of RS and they emerge when purposeful hand use is lost. Behind hand stereotypies there are also other type of stereotypies involving other parts of the body (personal observation): head rolling, eye rolling, trunk rocking, intermittent leg elevation and tapping of the floor, toe ...
Tópico(s): Child Nutrition and Feeding Issues
2006 - Thieme Medical Publishers (Germany) | Neuropediatrics
Produção Nacional
Revisado por pares
Daniela Pimenta Silva, Miguel Coelho, Tiago Soares, Thiago Cardoso Vale, Leonor Correia Guedes, Ricardo Maciel, Ana Antunes, Sarah Camargos, Anabela Valadas, Catarina Godinho, Débora Palma Maia, Patrícia Pita Lobo, Raphael Doyle Maia, Tiago Teodoro, Carlos Roberto de Mello Rieder, Ana Graça Velon, Vítor Tumas, Egberto Reis Barbosa, Hélio Afonso Ghizoni Teive, Henrique Ballalai Ferraz, Maria José Rosas, Ana Calado, Tânia Lampreia, Rita Moiron Simões, Nuno Vila‐Chã, Maria Manuela Costa, Margarida Rodrigues, Verónica Caniça, Francisco Cardoso, Joaquim J. Ferreira,
Handicap is a patient-centered measure of health status that encompasses the impact of social and physical environment on daily living, having been assessed in advanced and late-stage Parkinson's Disease (PD).
Tópico(s): Balance, Gait, and Falls Prevention
2023 - Wiley | Movement Disorders Clinical Practice