Produção Nacional
Pedro Nazareth Aguiar, Pui San Tan, Sarah Simko, Carmélia Maria Noia Barreto, Bárbara de Souza Gutierres, Auro del Giglio, Gilberto Lopes,
Objective To evaluate the cost-effectiveness of the addition of chemotherapy or abiraterone to androgen deprivation. Methods We developed an analytical model to determine the cost-effectiveness of the addition of docetaxel or abiraterone versus androgen deprivation therapy alone. Direct and indirect costs were included in the model. The effects were expressed in Quality-Adjusted Life Years adjusted for side effects. Results Compared to androgen deprivation therapy alone, the addition of chemotherapy ...
Tópico(s): Statistical Methods in Clinical Trials
2019 - Instituto Israelita de Ensino e Pesquisa Albert Einstein | Einstein (São Paulo)
Produção Nacional
Pedro Nazareth Aguiar, Carmélia Maria Noia Barreto, Bárbara de Souza Gutierres, Hakaru Tadokoro, Gilberto Lopes,
To assess the cost-effectiveness of chemohormonal therapy in patients with metastatic hormone-sensitive and non-metastatic high-risk prostate cancer.An analytical decision model was developed to determine the cost-effectiveness of chemohormonal therapy versus androgen deprivation therapy alone in patients with metastatic hormone-sensitive prostate cancer and patients with non-metastatic high-risk prostate cancer. The cost-effectiveness in metastatic patients with a high-volume disease was assessed ...
Tópico(s): Multiple and Secondary Primary Cancers
2017 - Instituto Israelita de Ensino e Pesquisa Albert Einstein | Einstein (São Paulo)
Produção Nacional
Revisado por pares
Laurylene César de Souza Vasconcelos, Fábio Correia Sampaio, Maria Carmélia Correia Sampaio, Maria do Socorro Vieira Pereira, Jane Sheila Higino, Maria Helena Pereira Peixoto,
The purpose of this study was to investigate the antimicrobial effect of a Punica granatum Linn (pomegranate) phytotherapeutic gel and miconazole (Daktarin® oral gel) against three standard streptococci strains (mutans ATCC 25175, sanguis ATCC 10577 and mitis ATCC 9811), S. mutans clinically isolated and Candida albicans either alone or in association. The effect of minimum inhibitory concentrations of the gels on the adherence of these microorganisms to glass was assessed in the presence of 5% sucrose, ...
Tópico(s): Pineapple and bromelain studies
2006 - Fundação Odontológica de Ribeirão Preto | Brazilian Dental Journal
Produção Nacional
Revisado por pares
Mariane Teodoro Fernandes, Jacob J. Adashek, Carmélia Maria Noia Barreto, Ana Cláudia Barbin Spinosa, Bárbara de Souza Gutierres, Gilberto Lopes, Auro del Giglio, Pedro Nazareth Aguiar,
In the last 3 years, a novel class of targeted therapy has been approved for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. There are currently three approved agents, which are oral cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. All of the approved drugs exhibit progression-free survival benefit when compared to standard of care and generally have less adverse events compared to traditional chemotherapeutic options. The treatment ...
Tópico(s): Cancer-related Molecular Pathways
2018 - BioExcel Publishing Ltd | Drugs in Context
Produção Nacional
Revisado por pares
Pedro Nazareth Aguiar, Ramon Andrade de Mello, Hakaru Tadokoro, Ilka Lopes Santoro, Hani M. Babiker, Kiran Avancha, Bárbara de Souza Gutierres, Carmélia Maria Noia Barreto, Gilberto Lopes,
Recent clinical trials have shown that immune checkpoint inhibitors are active against several neoplasms, including lung cancer. Tumor PD-L1 receptor expression is being studied as a predictive biomarker. The objective of our study is to assess the cost-effectiveness and economic impact of nivolumab and pembrolizumab with and without the use of PD-L1 as a biomarker. We developed a decision-analytic model to determine the cost-effectiveness of PD-L1 assessment and second-line treatment with NIVO ...
Tópico(s): Cancer Genomics and Diagnostics
2016 - Elsevier BV | Journal of Thoracic Oncology
Produção Nacional
Revisado por pares
Marina Cínthia de Sousa, Widson Michael dos Santos, Júlia Maria Orleans da Silva, Felipe Pereira Ramos, Aline Souza de Freitas, Maria Carmélia Almeida Neta, Karina Maria Olbrich dos Santos, Flávia Carolina Alonso Buriti, Eliane Rolim Florentino,
Tópico(s): Probiotics and Fermented Foods
2021 - Springer Science+Business Media | Probiotics and Antimicrobial Proteins
Lúcio Bakos, Arival Cardoso de Brito, Lia Cândida Miranda de Castro, Bernardo Gontijo, Gabriela Lowy, Carmélia Matos Santiago Reis, A M F Roselino Ribeiro, FRANCISCO HELDER CAVALCANTE SOUZA, MARIA DO LIVRAMENTO VILLAR, Clarisse Zaitz,
Background. Topical application of antifungal agents is considered the treatment of choice for dermatomycoses. Most of the available drugs are fungistatic, requiring long term treatment to prevent relapses. Terbinafine is a synthetic antifungal agent that, because of its fungicidal action, provides high cure rates and low relapse rates after short periods of treatment. Methods. Ninety-seven children ages 2 to 15 years with a suspected diagnosis of tinea corporis and/or tinea cruris were enrolled ...
Tópico(s): Plant Pathogens and Fungal Diseases
1997 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Produção Nacional
Revisado por pares
Pedro Nazareth Aguiar, Bárbara de Souza Gutierres, Carmélia Maria Noia Barreto, Ramon Andrade de Mello, Hakaru Tadokoro, Auro del Giglio, G. Lopes,
Immunotherapy was elected by ASCO as the most important advance in Oncology in the last 2 consecutive years. Harnessing the immune system to fight cancer cells has already changed clinical practice. Nevertheless, the cost of immune checkpoint inhibitors is a limitation to their incorporation in several countries, including Brazil. The objective of this study was to estimate the economic impact of immunotherapy and make suggestions in order to improve access for patients who benefit the most from ...
Tópico(s): Pharmaceutical Economics and Policy
2017 - Elsevier BV | Journal of Thoracic Oncology
Produção Nacional
Revisado por pares
Pedro Nazareth Aguiar, Ramon Andrade de Mello, Hakaru Tadokoro, Bárbara de Souza Gutierres, Carmélia Maria Noia Barreto, Hani M. Babiker, Gilberto Lopes,
Delivering high quality cancer care at an affordable cost is one of the main challenges for health care professionals and policy makers, especially in low- and middle-income countries. Imunne checkpoint inhibitors have achieved encouraging results in non-small cell lung cancer (NSCLC). Durable responses have been observed in approximately 20% of patients. Tumor PD-L1 receptor expression is being studied as a predictive biomarker. The objective of our study is to assess the economic impact of nivolumab ...
Tópico(s): Economic and Financial Impacts of Cancer
2016 - Elsevier BV | Journal of Thoracic Oncology
Produção Nacional
Priscila Moreira Cerqueira Oliveira, Alline Mikaele Nunes Wildemberg Brauer, Maria Carmélia Almeida Neta, Maria Carmélia Almeida Neta, Aramis Tupina Alcantara de Moreira, P Moura Santos, Deyse De Souza Carvalho da Silva, Marcela Miranda Salles,
Introdução: A Artrite Reumatoide (AR) é uma doença autoimune caracterizada pela inflamação das articulações, que pode provocar deformidades e afetar outros tecidos e órgãos. Os medicamentos biológicos representam um grande avanço no tratamento da AR. Estudos apontam que os biológicos disponíveis apresentam perfis de efetividade e segurança semelhantes. A gama de alternativas de tratamento torna possível a substituição de um biológico por outro em caso de falha terapêutica, reação adversa ou outros ...
Tópico(s): Public Health in Brazil
2020 - | Jornal de Assistência Farmacêutica e Farmacoeconomia
Produção Nacional
Priscila Moreira Cerqueira Oliveira, Maria Carmélia Almeida Neta, Alline Mikaele Nunes Wildemberg Brauer, Aramís Tupiná Alcântara de Moreira, Deyse Souza Carvalho da Silva, Marcela Miranda Salles, Lindemberg Assunção Costa, P Moura Santos,
Objetivos: Identificar as principais razões e estratégias de troca nas terapias biológicas em pacientes com artrite reumatoide (AR) atendidos em um Centro de Infusão de medicamentos biológicos de um Hospital Universitário do Nordeste do Brasil. Métodos: Realizou-se um estudo transversal com coleta retrospectiva de dados em uma amostra de pacientes cadastrados no Sistema Único de Saúde, que tiveram reposição biológica ao longo do tratamento. Coletamos dados de acompanhamento farmacêutico e prontuário, ...
Tópico(s): Biosimilars and Bioanalytical Methods
2021 - | Jornal de Assistência Farmacêutica e Farmacoeconomia
Deyse Souza Carvalho da Silva, Elen Barbosa De Jesus, Priscila Moreira Cerqueira Oliveira, Maria Carmélia Almeida Neta, Alline Mikaele Nunes Wildemberg Brauer, Aramis Tupina Alcantara de Moreira, Lindemberg Assunção Costa, P Moura Santos,
Introdução: A artrite reumatoide (AR) é uma doença crônica e autoimune que afeta as articulações, especialmente das extremidades do corpo. Tem prevalência mundial de 0.5% a 1% na população, atingindo majoritariamente as mulheres entre 30 e 50 anos de idade. O tratamento é ofertado gratuitamente através do Sistema Único de Saúde (SUS) que disponibiliza as drogas modificadoras do curso da doença (DMCD) sintéticas e biológicas. A qualidade de vida relacionada à saúde (QVRS) é uma medida que leva em consideração ...
Tópico(s): Public Health in Brazil
2020 - | Jornal de Assistência Farmacêutica e Farmacoeconomia
Produção Nacional
Revisado por pares
Bárbara de Souza Gutierres, Barbara B. Dourado, Ana Paula Negreiros Nunes Alves, Pedro Nazareth Aguiar, Carmélia Maria Noia Barreto, Gilberto Lopes, Auro del Giglio,
Evidence-based medicine was developed to guide medical decisions based upon the strongest scientific evidence available in the literature. However, large randomized clinical trials are expensive. In addition, new antineoplastic drugs development is also extremely expensive. Therefore, we hypothesized that the strongest evidence available nowadays comes from studies developed by the pharmaceutical industry. We carried out a search on network databases for studies published between 2014 and 2017. ...
Tópico(s): Economic and Financial Impacts of Cancer
2018 - Elsevier BV | Journal of Thoracic Oncology
Maria Carmélia Almeida Neta, Priscila Moreira Cerqueira Oliveira, Alline Mikaele Nunes Wildemberg Brauer, Aramís Tupiná Alcântara de Moreira, Leonardo Augusto Kister de Toledo, Deyse Souza Carvalho da Silva, Marcela Miranda Salles, Lindemberg Assunção Costa, P Moura Santos,
Objetivos: Identificar os principais motivos e estratégias de substituição de biológicos no tratamento de pacientes com diagnóstico de espondilite anquilosante (EA), cadastrados no Componente Especializado e assistidos em um centro de infusão de um hospital universitário de Salvador, BA. Métodos: Estudo observacional transversal, com coleta de dados retrospectiva, com pacientes com diagnóstico de EA em uso de biológico e que já tenham realizado, pelo menos, uma substituição dessa classe de medicamento. ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2019 - | Jornal de Assistência Farmacêutica e Farmacoeconomia
Produção Nacional
Revisado por pares
Carmélia Maria Noia Barreto, Pedro Nazareth Aguiar, F. Di Silverio, M. Yaksic, M.F. Manfrivato, L. Naraki, Virgílio Souza e Silva, P. Tamura, Keigo Kobayashi, L. Zapata, Tiago Costa de Pádua, Fernanda Priscila Alves da Silva, Massimiliano Spada, Raphael B. Parmigiani, N Yamaguchi,
Challenges in Precision and Personalized Medicine with interpatient variation needs individualized protocols. PARP Inhibition may be one modality of treatment of NSCLC, as coadjutant to chemotherapy. A 66 years old male has been diagnosed with lung adenocarcinoma since 02-06-2016, c T4 c N1 c M1a (pleura and pericardium), had been exposed to carboplatin and pemetrexed for 6 cycles (January to March 2016) with disease progression, and peripheral neuropathy. He didn't have EGFR mutation, ALK translocation, ...
Tópico(s): PARP inhibition in cancer therapy
2017 - Elsevier BV | Journal of Thoracic Oncology
Romanistische Abteilung, Kurzwerk Von, Hugo Grotius, D Ors, Una Explicación, Peloponnesischen Krieg, Rudolf Haensch, Das Statthalterarchiv, H Engst, Georg Klingen Ber G, Aristoteles Landau, Als Zivilrechtsdogmatiker, Stadtrömisches Wilhelm, Spiegel Der Lex Irnitana, Andreas Wacke, Zur Beweislast, Im Klassischen, Zivilprozeß Giovanni, Pug- Liese Versus, Ernst Levy, Reuven Yaron, Zu Babylonischen Eherechten, Ludwig Mitteis, Wenger Leopold, Brautpreis Ehe-Und Zinsrecht, Besitzes Ein Deutungsversuch, Pr Rainer, Joseph R. Michael, Karl-Heinz Ziegler, M Ahsmann, Collegia En Colleges Besprochen, Von Theo, V Prishchepov Alexander, Anzeige Von, Rainer Alföldy, Römische Géza, Herbert Graßl, Anzeige Von, Dieter Nörr, Besprochen Von, Adolf Lippold, Niedergang Aufstieg, Welt Der Römischen, Bde Teil, Dieter Benke, Franz-Stefan Nikolaus, Übungsbuch Meissel, Sachenrecht Zum Römi- Schen, Johanna Maria Filip-Fröschl, W Clarysse, Between Republic, Principate Hg, Klaus Von, M Raaflaub, Thomas Chaimowicz, Biographisches Repertorium Der Juristen, Alten Reich, A Von, F Ranieri, Gunter Wesener Bojarski, Wojciech Dajczak, Andrzej Sokala, W Von, Anzeige Bojarski, Andrzej Von, B. Kremer, L C de Souza Gabriel, Karl-Heinz Solución, Marcella Chelotti, Vincenza Morizio, M Sivestrini, Les Epigrafi Romane Di Canosa, Il Crimen Calumniae Anzeige, Dieter Cimma, Maria João Rosa, Nelle L'episcopalis Audientia, Giustiniano Besprochen, Karl Hackl, Corpus Iuris Civilis Bd, Okko Behrends, Johanna Filip-Fröschl D'ippolito, Sulla Federico, Besprochen Von Martin, Josef Schermaier D'ors, Alvaro Aufl, Besprochen Von Wieslaw, Litewski Dauchy, Les Voies, J Hilaire Besprochen, Ernst Holthöfer, V De Giovanni, Giuristi Lucio, Besprochen Severiani, Artur Von, Antoni Dçbinski, Ustawodawstwo Käme, Marek Kuryłowicz, Anzeige Von Kar, Hackl Domingo, Teoría De, Theo Mayer–Maly, Georg Friedrich, Rechtsgeschichte Thielmann, J. Martin, Hubert Niederländer, E Von, A Jayme, K Laufs, G Misera, Reid Reinhart, Johannes Michael Rainer, Heinze Schapp, Peter Mader, Rechtssprache Vorwort, Rezensionsmiszelle Flume, Rechtsakt Werner, Rechtsverhältnis Und, Von Besprochen, Wesener Gunter, Olga Tellegen-Couperus Giménez-Candela, Los Llamados Cuasidelitos Besprochen Von Alvaro D', Ors Grünewald, Constantinus Thomas, Augustus Maximus, Richard Klein Grziwotz, Römische, Besprochen Von Dietmar, Willoweit Habicht, Helga Botermann, Vii Herrmann, Kleine Schriften, Rechtsgeschichte Hg, Geschichte Von, Anzeige Schiemann, Wolfgang Von, Roman Wald Stein Herzog, Staaten Der Frühzeit, Anzeige Von, Hubert Kaufhold, Historikerlexikon Hg, R Von, Rolf Brück, Anzeige Müller, Josef Von Martin, Anzeige Von Gunter, Wesener Kinzig, Erbin Kirche, Anzeige Von Walter, Selb Köbler, Geschichtliche Gerhard, Besprochen Rechtswissenschaft, Werner Von, Jan Schubert Kodrçbski, Prawo Rzymskie W Polsce, Xix Wieku, Anzeige Von Marek, Kurylowicz Austen, Henry Layard Tre L'oriente, Venezia Hg, F Von, Brendan Hickey, Anzeige Von Gerhard, Ries Magdelain, Imperium Auctoritas, Selb Melillo, Antonio Generoso, Carmelia Palma, Lessico Pennacchio, Edictum Dell', Regis Theodorici, Sigrid Minderheiten, Mittelmeerraum Hg, Sigrid Deger-Jalkotzy, Joseph Modrzejewski, Anzeige Von, Dieter Nörr Möller, Freiheit Cosima, Arbeitsrecht Anzeige, Guglielmo Nocera, Georg Klingenberg,
Article Romanistische Abteilung. Inhalt des CIX. Bandes was published on August 1, 1992 in the journal Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Romanistische Abteilung (volume 109, issue 1).
Tópico(s): Diverse Legal and Medical Studies
1992 - Böhlau Verlag | Zeitschrift der Savigny-Stiftung für Rechtsgeschichte Romanistische Abteilung