Carole Bayer Sager, David Foster,
“The Prayer” won the Golden Globe Award for Best Original Song from the movie Quest for Camelot in 1999. It was nominated for an Academy Award for Best Original Song the same year, and a Grammy Award for Best Pop Collaboration with Vocals in 2000. Each ceremony featured a duet by Celine Dion and Andrea Bocelli. I pray you'll be our eyes And watch us where we go And help us to be wise In times when we don't know Let this be our prayer As we go our way Lead us to a place Guide us with your grace To ...
2011 - Lippincott Williams & Wilkins | Academic Medicine
Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia Moreno‐Grau, Najaf Amin, Adam C. Naj, Rafael Campos‐Martin, Benjamin Grenier‐Boley, Víctor Andrade, Peter Holmans, Anne Boland, Vincent Damotte, Sven J. van der Lee, Marcos R. Costa, Teemu Kuulasmaa, Qiong Yang, Itziar de Rojas, Joshua C. Bis, Amber Yaqub, Ivana Nedeljković, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo García‐González, Carla Abdelnour, Emilio Alarcón‐Martín, Daniel Alcolea, Montserrat Alegret, Ignacio Álvarez, Victoria Álvarez, Nicola J. Armstrong, Anthoula Tsolaki, Carmen Antúnez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Sandra Barral, Alexa S. Beiser, Ana Belén Pastor, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr, Céline Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Merçé Boada, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossù, Geir Bråthen, Jan Bressler, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis I. Brusco, Dolores Buiza‐Rueda, Katharina Bürger, Vanessa Burholt, William S. Bush, Miguel Calero, Laura B. Cantwell, Geneviève Chêne, Jaeyoon Chung, Michael L. Cuccaro, Ãngel Carracedo, Roberta Cecchetti, Laura Cervera‐Carles, Camille Charbonnier, Hung‐Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A.H.R. Claassen, Christopher Clark, Elisa Conti, Anaïs Corma‐Gómez, Emanuele Maria Costantini, Carlo Custodero, Delphine Daian, Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean‐François Dartigues, Peter Paul De Deyn, Kátia de Paiva Lopes, Lot D. de Witte, Stéphanie Debette, Jürgen Deckert, Teodoro del Ser, Nicola Denning, Anita L. DeStefano, Martin Dichgans, Janine Diehl‐Schmid, Mónica Díez-Fairén, Paolo Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Düzel, Carole Dufouil, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott‐Price, Ana Espinosa, Michael Ewers, Kelley M. Faber, Fabrizio Tagliavini, Yan V. Sun, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernández‐Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fließbach, Bernard Fongang, Myriam Fornage, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macías, María J. Bullido, Ana Frank, Lutz Froelich, Brian Fulton‐Howard, Daniela Galimberti, José María García‐Alberca, Pablo García‐González, Sebastián García‐Madrona, Guillermo García‐Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison Goate, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio González‐Pérez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grünblatt, Michelle Grunin, Vilmundur Guðnason, Tamar Guetta-Baranés, Annakaisa Haapasalo, Georgios M. Hadjigeorgiou, Jonathan L. Haines, Kara L. Hamilton‐Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann‐Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel Hernández, Martin J. Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels, Xueqiu Jian, Charlotte Johansson, Gyungah Jun, Yuriko Kastumata, John Kauwe, Patrick G. Kehoe, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Walter A. Kukull, Pavel P. Kuksa, Brian W. Kunkle, Amanda Kuzma, Carmen Lage, Erika J. Laukka, Lenore J. Launer, Alessandra Lauria, Chien‐Yueh Lee, Jenni Lehtisalo, Ondřej Lerch, Alberto Lleó, W.T. Longstreth, Oscar L. López, Adolfo López de Munain, Seth Love, Malin Löwemark, Lauren Luckcuck, Kathryn L. Lunetta, Yiyi Ma, Juan Macías, Catherine Macleod, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquié, Iain Marshall, Eden R. Martin, Angel Martín Montes, Carmen Martínez Rodríguez, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Miguel Medina, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menéndez‐González, Pablo Mir, Susanne Moebus, Merel O. Mol, Laura Molina‐Porcel, Laura Montrreal, Laura Morelli, Fermín Moreno, Kevin Morgan, Sonia Thomas, Markus M. Nöthen, Carolina Muchnik, Shubhabrata Mukherjee, Benedetta Nacmias, Tiia Ngandu, Gaël Nicolas, Børge G. Nordestgaard, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Paolo Caffarra, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Pau Pástor, Gina M. Peloso, Alba Pérez‐Cordón, Jordi Pèrez‐Tur, Pierre Péricard, Oliver Peters, Yolande A.L. Pijnenburg, Juan A. Pineda, Gerard Piñol-Ripoll, Claudia Pisanu, Thomas Polak, Julius Popp, Daniëlle Posthuma, Josef Priller, Raquel Puerta, Olivier Quenez, Inés Quintela, Jesper Qvist Thomassen, Alberto Rábano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luís Miguel Real, Marcel J. T. Reinders, Christiane Reitz, Dolly Reyes‐Dumeyer, Perry Ridge, Steffi G. Riedel‐Heller, Peter Riederer, Natalia Roberto, Eloy Rodríguez‐Rodríguez, Arvid Rongve, Irene Rosas Allende, Maitée Rosende-Roca, José Luís Royo, Elisa Rubino, Dan Rujescu, María Eugenia Sáez,
Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted ...
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Brian W. Kunkle, Benjamin Grenier‐Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J. van der Lee, Alexandre Amlie‐Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R. Martin, Kristel Sleegers, Nandini Badarinarayan, Jóhanna Jakobsdóttir, Kara L. Hamilton‐Nelson, Sonia Moreno‐Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B. Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N. Vardarajan, Jacques Epelbaum, Per Hoffmann, Merçé Boada, Gary W. Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L. Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V. Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C. Fox, Seung‐Hoan Choi, Ignacio Mateo, Joseph T. Hughes, Hieab H.H. Adams, John Malamon, Florentino Sanchez‐García, Yogen Patel, Jennifer A. Brody, Beth A. Dombroski, María Cándida Déniz Naranjo, Makrina Daniilidou, Guðný Eiríksdóttir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B. Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloé Sarnowski, William S. Bush, Stéphane Meslage, Johannes Kornhuber, Charles C. White, Yeunjoo E. Song, Robert C. Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M. Adams, Rik Vandenberghe, Manuel Mayhaus, L. Adrienne Cupples, Marilyn S. Albert, Peter Paul De Deyn, Wei Gu, J.J. Himali, Duane Beekly, Alessio Squassina, Annette M. Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodríguez‐Rodríguez, Simon Lovestone, Melissa E. Garcia, Rachelle S. Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas Fairchild, Yolanda A. Benito, Clive Holmes, Hata Karamujić‐Čomić, Matthew P. Frosch, Håkan Thonberg, Wolfgang Maier, Gennady V. Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M. Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J. Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C. Dirk Keene, Seppo Helisalmi, Iwona Kłoszewska, Walter A. Kukull, Anne M. Koivisto, Aoibhinn Lynch, Lluís Tárraga, Eric B. Larson, Annakaisa Haapasalo, Brian Lawlor, Sonia Thomas, Richard B. Lipton, Vincenzo Solfrizzi, Michael Gill, W. T. Longstreth, Thomas J. Montine, Vincenza Frisardi, Mónica Díez-Fairén, Fernando Rivadeneira, Ronald C. Petersen, Vincent Deramecourt, Ignacio Álvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M. Reiman, Nathalie Fiévet, Jerome I. Rotter, Joan Reisch, Olivier Hanon, Chiara Cupidi, André G. Uitterlinden, Donald R. Royall, Carole Dufouil, Raffaele Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George‐Hyslop, Karen Ritchie, Magda Tsolaki, Debby W. Tsuang, Bruno Dubois, David Craig, Chuang‐Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L. Albin, Laura Fratiglioni, Antonia Germanou, Liana G. Apostolova, Lina Keller, Maria Koutroumani, Steven E. Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice L. Whitehead, Craig Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ãngel Carracedo, Lars Lannfelt, David C. Rubinsztein, Lisa L. Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G. Beach, Janet Johnston, James T. Becker, Peter Passmore, Eileen H. Bigio, Jonathan M. Schott, Thomas D. Bird, Jason D. Warren, Bradley F. Boeve, Michelle K. Lupton, James D. Bowen, Petroula Proitsi, Adam Boxer, John Powell, James R. Burke, John S.K. Kauwe, Jeffrey M. Burns, Michelangelo Mancuso, Joseph D. Buxbaum, Ubaldo Bonuccelli, Nigel J. Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris Carlson, Nicholas Bass, Cynthia M. Carlsson, John Hardy, Regina M. Carney, José Brás, Minerva M. Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C. Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Neill R. Graff‐Radford, Denis A. Evans, Angela Hodges, Kelley M. Faber, Martin Scherer, Kenneth B. Fallon, Markus J. Riemenschneider, David W. Fardo, Reinhard Heun, Martin R. Farlow, Heike Kölsch, Steven H. Ferris, Markus Leber, Tatiana Foroud, Isabella Heuser, Douglas Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H. Geschwind, John R. Gilbert, John C. Morris, Robert C. Green, Kevin H. Mayo, John H. Growdon, Thomas Feulner, Ronald L. Hamilton, Lindy E. Harrell, Dmitriy Drichel, Lawrence S. Honig, Thomas D. Cushion, Matthew J. Huentelman, Paul Hollingworth, Christine M. Hulette, Bradley T. Hyman, Iain Marshall, Gail P. Jarvik, Alun Meggy, Erin L. Abner, Georgina Menzies, Lee‐Way Jin, Ganna Leonenko, Luís Miguel Real, Gyungah R Jun, Clinton T. Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jonathan Kaye, Ronald Kim, Frank Jessen, Neil W. Kowall, Bruno Vellas, Joel H. Kramer, Emma Vardy, Frank M. LaFerla, Karl‐Heinz Jöckel, James J. Lah, Martin Dichgans, James B. Leverenz,
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer’s or dementia. Fine-mapping ...
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Brian W. Kunkle, Benjamin Grenier‐Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J. van der Lee, Alexandre Amlie‐Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R. Martin, Kristel Sleegers, Nandini Badarinarayan, Jóhanna Jakobsdóttir, Kara L. Hamilton‐Nelson, Sonia Moreno‐Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N. Vardarajan, Jacques Epelbaum, Per Hoffmann, Merçé Boada, Gary W. Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L. Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V. Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C. Fox, Seung‐Hoan Choi, Ignacio Mateo, Joseph T. Hughes, Hieab H.H. Adams, John Malamon, Florentino Sanchez‐García, Yogen Patel, Jennifer A. Brody, Beth A. Dombroski, María Cándida Déniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B. Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloé Sarnowski, William S. Bush, Stéphane Meslage, Johannes Kornhuber, Charles C. White, Yeunjoo E. Song, Robert C. Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M. Adams, Rik Vandenberghe, Manuel Mayhaus, L. Adrienne Cupples, Marilyn S. Albert, Peter Paul De Deyn, Wei Gu, J.J. Himali, Duane Beekly, Alessio Squassina, Annette M. Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodríguez‐Rodríguez, Simon Lovestone, Melissa E. Garcia, Rachelle S. Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas Fairchild, Yolanda Aladro, Clive Holmes, Hata Karamujić‐Čomić, Matthew P. Frosch, Håkan Thonberg, Wolfgang Maier, Gennady V. Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M. Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M. Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J. Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C. Dirk Keene, Seppo Helisalmi, Iwona Kłoszewska, Walter A. Kukull, Anne M. Koivisto, Aoibhinn Lynch, Lluís Tárraga, Eric B. Larson, Annakaisa Haapasalo, Brian Lawlor, Sonia Thomas, Richard B. Lipton, Vincenzo Solfrizzi, Michael Gill, W. T. Longstreth, Thomas J. Montine, Vincenza Frisardi, Mónica Díez-Fairén, Fernando Rivadeneira, Ronald C. Petersen, Vincent Deramecourt, Ignacio Álvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M. Reiman, Nathalie Fiévet, Jerome I. Rotter, Joan Reisch, Olivier Hanon, Chiara Cupidi, André G. Uitterlinden, Donald R. Royall, Carole Dufouil, Raffaele Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George‐Hyslop, Karen Ritchie, Magda Tsolaki, Debby W. Tsuang, Bruno Dubois, David Craig, Chuang‐Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L. Albin, Laura Fratiglioni, Antonia Germanou, Liana G. Apostolova, Lina Keller, Maria Koutroumani, Steven E. Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice L. Whitehead, Craig Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ãngel Carracedo, Lars Lannfelt, David C. Rubinsztein, Lisa L. Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G. Beach, Janet Johnston, James T. Becker, Peter Passmore, Eileen H. Bigio, Jonathan M. Schott, Thomas D. Bird, Jason D. Warren, Bradley F. Boeve, Michelle K. Lupton, James D. Bowen, Petroula Proitsi, Adam Boxer, John Powell, James R. Burke, John Kauwe, Jeffrey M. Burns, Michelangelo Mancuso, Joseph D. Buxbaum, Ubaldo Bonuccelli, Nigel J. Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris Carlson, Nicholas Bass, Cynthia M. Carlsson, John Hardy, Regina M. Carney, José Brás, Minerva M. Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C. Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Caroline Graff, Denis A. Evans, Angela Hodges, Kelley M. Faber, Martin Scherer, Kenneth B. Fallon, Markus J. Riemenschneider, David W. Fardo, Reinhard Heun, Martin R. Farlow, Heike Kölsch, Steven H. Ferris, Markus Leber, Tatiana M. Foroud, Isabella Heuser, Douglas Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H. Geschwind, John R. Gilbert, John C. Morris, Robert C. Green, Kevin H. Mayo, John H. Growdon, Thomas Feulner, Ronald L. Hamilton, Lindy E. Harrell, Dmitriy Drichel, Lawrence S. Honig, Thomas D. Cushion, Matthew J. Huentelman, Paul Hollingworth, Christine M. Hulette, Bradley T. Hyman, Iain Marshall, Gail P. Jarvik, Alun Meggy, Erin L. Abner, Georgina Menzies, Lee‐Way Jin, Ganna Leonenko, Luís Miguel Real, Gyungah R Jun, Clinton T. Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jonathan Kaye, Ronald Kim, Frank Jessen, Neil W. Kowall, Bruno Vellas, Joel H. Kramer, Emma Vardy, Frank M. LaFerla, Karl‐Heinz Jöckel, James J. Lah, Martin Dichgans, James B. Leverenz,
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Gyungah Jun, Carla A. Ibrahim‐Verbaas, Maria Vronskaya, Jean‐Charles Lambert, Jaeyoon Chung, Adam C. Naj, Brian W. Kunkle, Li‐Shun Wang, Joshua C. Bis, Céline Bellenguez, Denise Harold, Kathryn L. Lunetta, Anita L. DeStefano, Benjamin Grenier‐Boley, Rebecca Sims, Gary W. Beecham, Albert V. Smith, Vincent Chouraki, Kara L. Hamilton‐Nelson, M. Arfan Ikram, Nathalie Fiévet, Nicola Denning, Eden R. Martin, Helena Schmidt, Yoichiro Kamatani, Melanie Dunstan, Otto Valladares, Agustín Ruiz Laza, Diana Zélénika, Alfredo Ramı́rez, Tatiana Foroud, Sung‐Hyuk Choi, Anne Boland, Tim Becker, Walter A. Kukull, Sven J. van der Lee, Florence Pasquier, Carlos Cruchaga, Duane Beekly, Annette L. Fitzpatrick, Olivier Hanon, Michael Gill, Robert C. Barber, Vilmundur Guðnason, Dominique Campion, Seth Love, David A. Bennett, Najaf Amin, Claudine Berr, Magda Tsolaki, Joseph D. Buxbaum, Oscar L. López, Vincent Deramecourt, Nick C. Fox, Laura B. Cantwell, Lluís Tárraga, Carole Dufouil, John Hardy, Paul K. Crane, Gudny Eiriksdottir, Didier Hannequin, Robert Clarke, Denis A. Evans, Thomas H. Mosley, Luc Letenneur, Carol Brayne, Wolfgang Maier, Philip L. De Jager, Valur Emilsson, Dartigues Jf, Harald Hampel, M. Ilyas Kamboh, Renée F.A.G. de Bruijn, Christophe Tzourio, Pau Pástor, Eric B. Larson, Jerome I. Rotter, Michael O’Donovan, Thomas J. Montine, Michael A. Nalls, Simon Mead, Eric M. Reiman, Pálmi V. Jónsson, Clive Holmes, Peter St George‐Hyslop, Merçé Boada, Peter Passmore, Jens R. Wendland, R. Schmidt, Kevin Morgan, Ashley R. Winslow, John Powell, M Carasquillo, Steven G. Younkin, Jóhanna Jakobsdóttir, John Kauwe, Kirk C. Wilhelmsen, Dan Rujescu, Markus M. Nöthen, Albert Hofman, Lesley Jones, Perrie M. Adams, Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig Atwood, Clinton T. Baldwin, Michjael M Barmada, Lisa L. Barnes, Thomas G. Beach, James T. Becker, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James R. Burke, Nigel J. Cairns, Chuanhai Cao, Chris Carlson, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Steven L. Carroll, Helena C. Chui, David G. Clark, Jason J. Corneveaux, David H. Cribbs, Elizabeth Crocco, Carlos Cruchaga, Philip L. De Jager, Charles DeCarli, Steven T. DeKosky, F. Yesim Demirci, Malcolm Dick, Dennis W. Dickson, Rachelle S. Doody, Ranjan Duara, Nilüfer Ertekin‐Taner, Kelley M. Faber, Thomas Fairchild, Kenneth B. Fallon, Martin R. Farlow, Steven H. Ferris, Matthew P. Frosch, Douglas Galasko, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Jonathan D. Glass, Caroline Graff, Robert C. Green, John H. Growdon, Hákon Hákonarson, Ronald L. Hamilton, John Hardy, Lindy E. Harrell, Elizabeth Head, Lawrence S. Honig, Ryan Huebinger, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Gail P. Jarvik, Gregory A. Jicha, Lee‐Way Jin, Anna Karydas, John SK Kauwe, Jonathan Kaye, Ronald Kim, Edward H. Koo, Neil W. Kowall, Joel H. Kramer, Frank M. LaFerla, James J. Lah, James B. Leverenz, Allan I. Levey, Li Ge, Andrew P. Lieberman, Chiao‐Feng Lin, Oscar L. López, Constantine G. Lyketsos, Wendy J. Mack, Daniel Marson, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Wayne C. McCormick, Susan M. McCurry, Andrew McDavid, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, John C. Morris, Shubhabrata Mukherjee, Jill R. Murrell, Amanda Myers, Sid E. O’Bryant, John Olichney, V. Shane Pankratz, Joseph E. Parisi, Amanda Partch, Henry L. Paulson, William Perry, Elaine R. Peskind, Ronald Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray A. Raskind, Barry Reisberg, Joan Reisch, Christiane Reitz, John M. Ringman, Erik D. Roberson, Ekaterina Rogaeva, Howard J. Rosen, Roger N. Rosenberg, Donald R. Royall, Mark A. Sager, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Rudolph E. Tanzi, Tricia A. Thornton‐Wells, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. Van Eldik, Badri N. Vardarajan, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Jennifer Williamson, Sarah Wishnek, Randall L. Woltjer, Clinton B. Wright, Chuang‐Kuo Wu, Chang-En Yu, Lei Yu, Rhoda Au, Philip A. Wolf, Alexa S. Beiser, Claudia L. Satizábal, André G. Uitterlinden, Fernando Rivadeneira, Peter J. Koudstaal, W.T. Longstreth, James T. Becker, Lewis H. Kuller, Thomas Lumley, Kenneth Rice, Tamara B Harris, Michael A. Nalls, Josef Marksteiner, Peter Dal‐Bianco, Anna Maria Töglhofer, Paul Freudenberger, Gerhard Ransmayr, Thomas Benke, Anna M. Toeglhofer, Eric Boerwinkle, Jan Bressler, Myriam Fornage, Francisco Jesús Morón, Isabel Hernández, Maitee Rosende Roca, Ana Mauleón, Montserrat Alegret, Reposo Ramírez‐Lorca, Antonio González-Perez, Annick Alpérovitch, Victoria Álvarez, Pascale Barberger‐Gateau, Karolien Bettens, Paola Bossù, Alexis Brice, María J. Bullido, P Caffara, Jordi Clarimón,
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 352 cases and 9207 controls) and APOE ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ɛ4 status. Suggestive associations (P<1 × 10(-4)) in stage ...
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