Samantha A. Spangler, Sabine Schmitz, Josta T. Kevenaar, Esther de Graaff, Heidi de Wit, Jeroen Demmers, Ruud F. Toonen, Casper C. Hoogenraad,
The presynaptic active zone mediates synaptic vesicle exocytosis, and modulation of its molecular composition is important for many types of synaptic plasticity. Here, we identify synaptic scaffold protein liprin-α2 as a key organizer in this process. We show that liprin-α2 levels were regulated by synaptic activity and the ubiquitin–proteasome system. Furthermore, liprin-α2 organized presynaptic ultrastructure and controlled synaptic output by regulating synaptic vesicle pool size. The presence ...
Tópico(s): RNA Interference and Gene Delivery
2013 - Rockefeller University Press | The Journal of Cell Biology
Jasper W.L. Hartog, Ruud M. van de Wal, Casper G. Schalkwijk, Toshio Miyata, Wybren Jaarsma, H.W. Thijs Plokker, Leen M. van Wijk, Andries J. Smit, Dirk J. van Veldhuisen, Adriaan A. Voors,
Tópico(s): Blood Pressure and Hypertension Studies
2010 - Elsevier BV | European Journal of Heart Failure
Kenneth D. Harris, Ruud Cuypers, Patrick Scheibe, Casper L. van Oosten, Cees W. M. Bastiaansen, Johan Lub, Dirk J. Broer,
Well-defined gradients in molecular alignment have been used as tools to generate large amplitude, light-induced deformations in stiff polymer networks. These systems are reversible, monolithic and based on a simple one-step self-assembly process. To fabricate the actuators, diacrylate dopants containing azobenzene moieties were blended with liquid crystalline diacrylate hosts and photopolymerized in a twisted configuration. The resulting twisted networks were heavily crosslinked with room temperature ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2005 - Royal Society of Chemistry | Journal of Materials Chemistry
Nicole Verzijl, Jeroen DeGroot, Chaya Ben Zaken, Orit Braun-Benjamin, Alice Maroudas, Ruud A. Bank, J. Mizrahi, Casper G. Schalkwijk, Suzanne R. Thorpe, John Baynes, J. W. J. Bijlsma, Floris P. J. G. Lafeber, Johan M. TeKoppele,
Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage collagen. We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage.To increase AGE levels, human adult articular cartilage was incubated with threose. The stiffness of the collagen network was measured as the instantaneous deformation (ID) of the cartilage and as the change ...
Tópico(s): Inflammatory mediators and NSAID effects
2002 - Wiley | Arthritis & Rheumatism
Willem L. J. Weijs, Casper Coppen, Ruud Schreurs, Rinaldo D. Vreeken, Arico C. Verhulst, Matthias A.W. Merkx, Stefaan Bergé, Thomas Maal,
Since reconstruction of composite defects in the head and neck region is a challenging and demanding problem for head and neck surgeons, surgical aids have been sought for decades. The purpose of this study was to evaluate the accuracy of prefabricated surgical resection templates used in mandibular segmental resections in comparison to the virtual surgical plan. A prospective study was performed in 11 consecutive patients, with a primary T4 oral squamous cell carcinoma or osteoradionecrosis of ...
Tópico(s): Facial Trauma and Fracture Management
2016 - Elsevier BV | Journal of Cranio-Maxillofacial Surgery
Jógvan Magnus Haugaard Olsen, Casper Steinmann, Kenneth Ruud, Jacob Kongsted,
We present a new QM/QM/MM-based model for calculating molecular properties and excited states of solute-solvent systems. We denote this new approach the polarizable density embedding (PDE) model, and it represents an extension of our previously developed polarizable embedding (PE) strategy. The PDE model is a focused computational approach in which a core region of the system studied is represented by a quantum-chemical method, whereas the environment is divided into two other regions: an inner and ...
Tópico(s): Advanced Chemical Physics Studies
2015 - American Chemical Society | The Journal of Physical Chemistry A
H. Marieke Schuppert, Casper J. Albers, Ruud B. Minderaa, Paul M.G. Emmelkamp, Maaike H. Nauta,
A combination of multiple factors, including a strong genetic predisposition and environmental factors, are considered to contribute to the developmental pathways to borderline personality disorder (BPD). However, these factors have mostly been investigated retrospectively, and hardly in adolescents. The current study focuses on maternal factors in BPD features in adolescence.Actual parenting was investigated in a group of referred adolescents with BPD features (N = 101) and a healthy control group ( ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2012 - BioMed Central | Child and Adolescent Psychiatry and Mental Health
H. Marieke Schuppert, Casper J. Albers, Ruud B. Minderaa, Paul M.G. Emmelkamp, Maaike H. Nauta,
The development of borderline personality disorder (BPD) has been associated with parenting styles and parental psychopathology. Only a few studies have examined current parental rearing styles and parental psychopathology in relationship to BPD symptoms in adolescents. Moreover, parenting stress has not been examined in this group. The current study examined 101 adolescents (14-19 years old) with BPD symptoms and their mothers. Assessments were made on severity of BPD symptoms, youth-perceived maternal ...
Tópico(s): Autism Spectrum Disorder Research
2014 - Guilford Press | Journal of Personality Disorders
Mark M. G. Mulder, Joep Schellens, Jan-Willem E. M. Sels, Frank van Rosmalen, Anne‐Marije Hulshof, Femke de Vries, Ruud Segers, Casper Mihl, Walther van Mook, Aalt Bast, Henri M.H. Spronk, Yvonne Henskens, Iwan C.C. van der Horst, Hugo Ten Cate, Leon J. Schurgers, Marjolein Drent, Bas C. T. van Bussel,
Extra-hepatic vitamin K-status, measured by dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP), maintains vascular health, with high levels reflecting poor vitamin K status. The occurrence of extra-hepatic vitamin K deficiency throughout the disease of COVID-19 and possible associations with pulmonary embolism (PE), and mortality in intensive care unit (ICU) patients has not been studied. The aim of this study was to investigated the association between dp-ucMGP, at endotracheal intubation ( ...
Tópico(s): Alcoholism and Thiamine Deficiency
2023 - BioMed Central | Journal of Intensive Care
Léon Bettendorf, A. van der Horst, Nick Draper, Casper van Ewijk, Ruud de Mooij, Harry ter Rele,
The ageing of the population imposes a considerable burden on long-term public finances in most industrialized countries. Generational accounting has been used across the world to assess the generational imbalance associated with current public policies. In this study, we incorporate Dutch generational accounts in an open economy overlapping generations model to assess the sustainability gap in current Dutch public finances. Our central estimate of the gap is 4.5% of gdp, but the paper also shows ...
Tópico(s): Gender, Labor, and Family Dynamics
2011 - Springer Nature | De Economist
E. B. Haagsma, J.R. Huizenga, Roel J. Vonk, Casper J. Albers, Joris Grond, Ruud A. F. Krom, Ch Gips,
In 20 adult patients undergoing orthotopic liver transplantation (OLT), we studied longitudinally for the first 3 weeks after OLT the composition of bile with regard to differences between surviving and non-surviving patients and between patients with more or less rejection and the relation between bile and serum concentrations. The analyzed biliary components were bilirubin, cholesterol, bile acids, phospholipids, copper, iron, glucose, urea, creatinine, ammonia, protein, sodium, potassium, chloride, ...
Tópico(s): Liver Disease Diagnosis and Treatment
1987 - Taylor & Francis | Scandinavian Journal of Gastroenterology
Casper J. Albers, J.R. Huizenga, Ruud A. F. Krom, R J Vonk, Ch Gips,
To define reference values of human hepatic bile for sodium, potassium, chloride, calcium, iron, copper, urea, creatinine, phosphate, glucose, bilirubin, cholesterol, protein, bile salts, phospholipids, ammonia, pH, PCO2, bicarbonate and osmolarity, bile was obtained via a T-drain from 12 adult patients who underwent cholecystectomy. Bile of females had a higher cholesterol concentration than that of males. The saturation index, however, was not different in both groups.
Tópico(s): Cannabis and Cannabinoid Research
1985 - SAGE Publishing | Annals of Clinical Biochemistry International Journal of Laboratory Medicine
Casper W. Quist, Gerrit Gort, Christian Mulder, Ruud H. P. Wilbers, A.J. Termorshuizen, Jaap Bakker, Johannes Helder,
Abstract Soil biota are responsible for essential ecosystem services such as carbon storage, nutrient cycling and water retention. However, assessment of the condition of soil biota is hampered by an overwhelming level of diversity. With representatives in all trophic levels of the food web, nematode communities can be used as bioindicators. Accurate assessment of nematode assemblages requires insight into the distribution of specimens with distinct food preferences. With the availability of taxon‐ ...
Tópico(s): Isotope Analysis in Ecology
2017 - Wiley | Molecular Ecology Resources
Casper Tax, Marlie Steenbergen, Petra L.M. Zusterzeel, Ruud L.M. Bekkers, Maroeska M. Rovers,
Data on health-related quality of life (HRQoL) is paramount for shared and evidence based decision-making. Since an overview of cervical cancer HRQoL tools and their validity appears to be lacking, we performed a systematic review on usage of disease specific HRQoL instruments in cervical cancer patients and their psychometric properties to identify the most suitable cervical cancer specific HRQoL tool. We searched Pubmed, EMBASE and PsycINFO from inception up to 18 October 2016 for studies on quality ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2017 - BioMed Central | BMC Medical Research Methodology
Jógvan Magnus Haugaard Olsen, Casper Steinmann, Kenneth Ruud, Jacob Kongsted,
... MM-based Computational Strategy"Jógvan Magnus Haugaard Olsen*, Casper Steinmann, Kenneth Ruud, and Jacob Kongsted*Cite this: J. Phys. Chem. ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2015 - American Chemical Society | The Journal of Physical Chemistry A
Jonas Kristoffer Lindeløv, Jonas Olsen Dall, Casper Daniel Kristensen, Marie Holt Aagesen, Stine Almgren Olsen, Therese Ruud Snuggerud, Anna Sikorska,
Working memory impairments are prevalent among patients with acquired brain injury (ABI). Computerised training targeting working memory has been researched extensively using samples from healthy populations but this field remains isolated from similar research in ABI patients. We report the results of an actively controlled randomised controlled trial in which 17 patients and 18 healthy subjects completed training on an N-back task. The healthy group had superior improvements on both training tasks ( ...
Tópico(s): Cognitive Functions and Memory
2016 - Taylor & Francis | Neuropsychological Rehabilitation
Casper van Ewijk, Bas Jacobs, Ruud de Mooij,
The tax treatment of owner-occupied housing has been subject to considerable public debate in industrialised countries.Home ownership usually receives a tax-favoured status.For instance, governments often do not tax capital gains on houses, they tax imputed rents on houses only lightly -if they tax them at all -and mortgage interest can sometimes be deducted from the income tax.During the 1970s, there was a broad increase in the implicit subsidisation of home ownership in many countries.However, during ...
Tópico(s): demographic modeling and climate adaptation
2007 - Springer Nature | De Economist
Chuan Jia Du, Ji He Zhou, Shuai Wang,
... professional players from 2016 Chengdu ITF Junior Masters: Casper RUUD and Miomir Kecmanovic. The purpose of the study ...
Tópico(s): Stroke Rehabilitation and Recovery
2016 - EDP Sciences | MATEC Web of Conferences
Casper Tax, Maroeska M. Rovers, Corine de Graaf, Petra L.M. Zusterzeel, Ruud L.M. Bekkers,
Objective Recent reviews on the sentinel lymph node (SLN) procedure in cervical cancer have shown that bilateral SLN detection and ultra staging are safe and superior options compared to a unilateral detection, frozen section and H&E analysis. So far, nobody identified a subgroup of patients in whom a SLN procedure may replace pelvic lymph node dissection (PLND). Methods We searched PubMed, Embase, CINAHL and Cochrane from inception up to November 26, 2014. Studies reporting SLN detection, and/or ...
Tópico(s): Colorectal and Anal Carcinomas
2015 - Elsevier BV | Gynecologic Oncology
Casper Tax, Karin Abbink, Maroeska M. Rovers, Ruud L.M. Bekkers, Petra L.M. Zusterzeel,
Currently, a PET-CT is used to assess the need for extended field radiotherapy of para-aortic lymph nodes (PALN) in International Federation of Gynaecology and Obstetrics (FIGO) stage IB2, IIA2–IVA (locally advanced stage) cervical cancer. A small study established a sensitivity and specificity estimate for PALN metastases of 50% (95% CI; 7–93%) and 83% (95% CI; 52–98%), respectively. Surgical staging of PALN may lead to a higher diagnostic accuracy. However, surgical staging of para-aortic lymph nodes ...
Tópico(s): Ovarian cancer diagnosis and treatment
2018 - BioMed Central | Pilot and Feasibility Studies
Casper R. Quispel, Tijs Duivenvoorden, Stefan Beekhuizen, Hennie Verburg, Anneke Spekenbrink–Spooren, Liza N. van Steenbergen, Jantsje H. Pasma, Ruud de Ridder,
Tópico(s): Orthopedic Infections and Treatments
2020 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Sai Ping Lau, Larissa Klaase, Marianne Vink, Jasper Dumas, Koen Bezemer, Anneloes van Krimpen, Ruud van der Breggen, Leonoor V. Wismans, Michail Doukas, Willem de Koning, Andrew Stubbs, Dana A. M. Mustafa, Heleen Vroman, Ralph Stadhouders, Joana B. Nunes, Christoph Stingl, Noel F.C.C. de Miranda, Theo M. Luider, Sjoerd H. van der Burg, Joachim G.J.V. Aerts, Casper H.J. van Eijck,
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its poor prognosis even after curative resection. Responses to immunotherapy are rare and related to inadequate T-cell priming. We previously demonstrated the potency of allogeneic lysate-dendritic cell (DC) vaccination in a preclinical model. Here we translate this concept to patients.In this phase I study, patients with resected PDAC were included when they demonstrated no radiologic signs of recurrence after standard-of-care treatment. Allogeneic ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2022 - Elsevier BV | European Journal of Cancer
Casper Reijnen, Stephanie Vrede, Astrid Eijkelenboom, Ruud Draak, Sanne Sweegers, Marc P.L.M. Snijders, Puck van Gestel, Johanna M.A. Pijnenborg, Johan Bulten, Heidi V.N. Küsters‐Vandevelde,
Abstract Background Uterine clear cell carcinoma (CCC) consists of either pure clear cell histology but can also display other histological components (mixed uterine CCCs). In this study, the molecular and immunohistochemical background of pure and mixed uterine CCC was compared. Secondly, it was evaluated whether histological classification and molecular background affected clinical outcome. Methods A retrospective multicenter study was performed comparing pure uterine CCCs ( n = 22) and mixed uterine ...
Tópico(s): Sarcoma Diagnosis and Treatment
2023 - Wiley | Cancer Medicine
Eleonora Porcu, Sina Rüeger, Kaido Lepik, Mawussé Agbessi, Habibul Ahsan, Isabel Alves, Anand Kumar Andiappan, Wibowo Arindrarto, Philip Awadalla, Alexis Battle, Frank Beutner, Marc Jan Bonder, Dorret I. Boomsma, Mark Christiansen, Annique Claringbould, Patrick Deelen, Tõnu Esko, Marie-Julie Favé, Lude Franke, Timothy M. Frayling, Sina A. Gharib, Gregory Gibson, Bastiaan T. Heijmans, Gibran Hemani, Rick Jansen, Mika Kähönen, Anette Kalnapenkis, Silva Kasela, Johannes Kettunen, Yungil Kim, Holger Kirsten, Péter Kovács, Knut Krohn, Jaanika Kronberg-Guzman, Viktorija Kukushkina, Bernett Lee, Terho Lehtimäki, Markus Loeffler, Urko M. Marigorta, Hailang Mei, Lili Milani, Grant W. Montgomery, Martina Müller‐Nurasyid, Matthias Nauck, Michel G. Nivard, Brenda W.J.H. Penninx, Markus Perola, Natalia Pervjakova, Brandon L. Pierce, Joseph E. Powell, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Samuli Ripatti, Olaf Rötzschke, Ashis Saha, Markus Scholz, Katharina Schramm, Ilkka Seppälä, P. Eline Slagboom, Coen D.A. Stehouwer, Michael Stümvoll, Patrick Sullivan, Peter A.C. ‘t Hoen, Alexander Teumer, Joachim Thiery, Tong Lin, Anke Tönjes, Jenny van Dongen, Maarten van Iterson, Joyce B. J. van Meurs, Jan H. Veldink, Joost Verlouw, Peter M. Visscher, Uwe Völker, Urmo Võsa, Harm-Jan Westra, Cisca Wijmenga, Hanieh Yaghootkar, Jian Yang, Biao Zeng, Futao Zhang, Wibowo Arindrarto, Marian Beekman, Dorret I. Boomsma, Jan Bot, Joris Deelen, Patrick Deelen, Lude Franke, Bastiaan T. Heijmans, Peter A.C. ‘t Hoen, Bert A. Hofman, Jouke‐Jan Hottenga, Aaron Isaacs, Marc Jan Bonder, P. Mila Jhamai, Rick Jansen, Szymon M. Kiełbasa, Nico Lakenberg, René Luijk, Hailiang Mei, Matthijs Moed, Irene Nooren, René Pool, Casper G. Schalkwijk, P. Eline Slagboom, Coen D.A. Stehouwer, H. Eka D. Suchiman, Morris A. Swertz, Ettje F. Tigchelaar, André G. Uitterlinden, Leonard H. van den Berg, Ruud van der Breggen, Carla Kallen, Freerk van Dijk, Jenny van Dongen, Cornelia M. van Duijn, Michiel van Galen, Marleen M. J. van Greevenbroek, Diana van Heemst, Maarten van Iterson, Joyce B. J. van Meurs, Jeroen van Rooij, Peter van’t Hof, Erik W. van Zwet, Martijn Vermaat, Jan H. Veldink, Michaël Verbiest, Marijn Verkerk, Cisca Wijmenga, Dasha V. Zhernakova, Sasha Zhernakova, Federico Santoni, Alexandre Reymond, Zoltán Kutalik,
Abstract Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs, indicating their potential involvement in regulation of gene expression. Here, we propose a transcriptome-wide summary statistics-based Mendelian Randomization approach (TWMR) that uses multiple SNPs as instruments and multiple gene expression traits as exposures, simultaneously. ...
Tópico(s): Genetic Syndromes and Imprinting
2019 - Nature Portfolio | Nature Communications
Jenny van Dongen, Michel G. Nivard, Gonneke Willemsen, Jouke‐Jan Hottenga, Quinta Helmer, Conor V. Dolan, Erik A. Ehli, Gareth E. Davies, Maarten van Iterson, Charles E. Breeze, Stephan Beck, Peter A.C. ‘t Hoen, René Pool, Marleen M. J. van Greevenbroek, Coen D.A. Stehouwer, Carla Kallen, Casper G. Schalkwijk, Cisca Wijmenga, Sasha Zhernakova, Ettje F. Tigchelaar, Marian Beekman, Joris Deelen, Diana van Heemst, Jan H. Veldink, Leonard H. van den Berg, Cornelia M. van Duijn, Bert A. Hofman, André G. Uitterlinden, P. Mila Jhamai, Michaël Verbiest, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Jan Bot, Dasha V. Zhernakova, Peter van’t Hof, Patrick Deelen, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Marc Jan Bonder, Freerk van Dijk, Michiel van Galen, Wibowo Arindrarto, Szymon M. Kiełbasa, Morris A. Swertz, Erik W. van Zwet, Aaron Isaacs, Lude Franke, H. Eka D. Suchiman, Rick Jansen, Joyce B. J. van Meurs, Bastiaan T. Heijmans, P. Eline Slagboom, Dorret I. Boomsma,
Abstract The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability ...
Tópico(s): Health, Environment, Cognitive Aging
2016 - Nature Portfolio | Nature Communications
Vassily Trubetskoy, Antonio F. Pardiñas, Ting Qi, Georgia Panagiotaropoulou, Swapnil Awasthi, Tim B. Bigdeli, Julien Bryois, Chia‐Yen Chen, Charlotte Dennison, Lynsey S. Hall, Max Lam, Kyoko Watanabe, Oleksandr Frei, Tian Ge, Janet Harwood, Frank Koopmans, Sigurður H. Magnússon, Alexander Richards, Julia Sidorenko, Yang Wu, Jian Zeng, Jakob Grove, Minsoo Kim, Zhiqiang Li, Georgios Voloudakis, Wen Zhang, Mark J. Adams, Ingrid Agartz, Elizabeth G. Atkinson, Esben Agerbo, Mariam Al Eissa, Margot Albus, Madeline Alexander, Behrooz Z. Alizadeh, Köksal Alptekın, Thomas D. Als, Farooq Amin, Volker Arolt, Manuel Arrojo, Lavinia Athanasiu, M.H. Azevedo, Silviu‐Alin Bacanu, Nicholas Bass, Martin Begemann, Richard A. Belliveau, Judit Bene, Beben Benyamin, Sarah E. Bergen, Giuseppe Blasi, Julio Bobes, Stefano Bonassi, Alice Braun, Rodrigo A. Bressan, Evelyn J. Bromet, Richard Bruggeman, P.F. Buckley, Randy L. Buckner, Jonas Bybjerg‐Grauholm, Wiepke Cahn, Murray J. Cairns, Monica E. Calkins, Vaughan J. Carr, David Castle, Stanley V. Catts, Kimberley D. Chambert, Raymond Chan, Boris Chaumette, Wei Cheng, Eric F.C. Cheung, Siow Ann Chong, David Cohen, Angèle Consoli, Quirino Cordeiro, Javier Costas, Charles Curtis, Michael Davidson, Kenneth L. Davis, Lieuwe de Haan, Franziska Degenhardt, Lynn E. DeLisi, Ditte Demontis, Faith Dickerson, Dimitris Dikeos, Timothy G. Dinan, Srdjan Djurovic, Jubao Duan, Giuseppe Ducci, Frank Dudbridge, Johan G. Eriksson, Lourdes Fañanás, Stephen V. Faraone, Alessia Fiorentino, Andreas J. Forstner, Josef Frank, Nelson B. Freimer, Menachem Fromer, Alessandra Frustaci, Ary Gadelha, Giulio Genovese, Elliot S. Gershon, Marianna Giannitelli, Ina Giegling, Paola Giusti‐Rodríguez, Stephanie Godard, Jacqueline I. Goldstein, Javier González‐Peñas, Ana González‐Pinto, Srihari Gopal, Jacob Gratten, Michael F. Green, Tiffany A. Greenwood, Olivier Guillin, Sinan Gülöksüz, Raquel E. Gur, Ruben C. Gur, Blanca Gutiérrez, Eric Hahn, Hákon Hákonarson, Vahram Haroutunian, Annette M. Hartmann, Carol Harvey, Caroline Hayward, Frans A. Henskens, Stefan Herms, Per Hoffmann, Daniel P. Howrigan, Masashi Ikeda, Conrad Iyegbe, Inge Joa, Antonio Julià, Anna K. Kähler, Tony Kam-Thong, Yoichiro Kamatani, Sena Karachanak-Yankova, Oussama Kébir, Matthew C. Keller, Brian Kelly, Andrey Khrunin, Sung‐Wan Kim, Jānis Kloviņš, N V Kondratiev, Bettina Konte, Julia Kraft, Michiaki Kubo, Vaidutis Kučinskas, Zita Aušrelė Kučinskienė, Agung Kusumawardhani, Hana Kuzelova-Ptackova, Stefano Landi, Laura C. Lazzeroni, Susan J. Lee, Sophie E. Legge, Douglas S. Lehrer, Rebecca Lencer, Bernard Lerer, Miaoxin Li, Jeffrey A. Lieberman, Gregory A. Light, Limborskaia Sa, Chih‐Min Liu, Jouko Lönnqvist, Carmel M. Loughland, Jan Lubiński, Jurjen J. Luykx, Amy Lynham, Milan Maçek, Andrew Mackinnon, Patrik K. E. Magnusson, Brion S. Maher, Wolfgang Maier, Dolores Malaspina, Jacques Mallet, Stephen R. Marder, Sara Marsal, Joanna Martin, Lourdes Martorell, Manuel Mattheisen, Robert W. McCarley, Colm McDonald, John J. McGrath, Helena Medeiros, Sandra Meier, Béla Melegh, Ingrid Melle, Raquelle I. Mesholam‐Gately, Andres Metspalu, Patricia T. Michie, Lili Milani, Vihra Milanova, Marina Mitjans, Espen Molden, Esther Molina, María Dolores Moltó, Valeria Mondelli, Carmen Moreno, Christopher P. Morley, Gerard Muntané, Kieran C. Murphy, Inez Myin‐Germeys, Igor Nenadić, Gerald Nestadt, Liene Ņikitina-Zaķe, Cristiano Noto, Keith H. Nuechterlein, Niamh L. O’Brien, F. Anthony O’Neill, Sang-Yun Oh, Ann Olincy, Vanessa Kiyomi Ota, Christos Pantelis, George N. Papadimitriou, Mara Parellada, Tiina Paunio, Renata Pellegrino, Sathish Periyasamy, Diana O. Perkins, Bruno Pfuhlmann, Olli Pietiläinen, Jonathan Pimm, David J. Porteous, John Powell, Diego Quattrone, Digby Quested, Allen D. Radant, Antonio Rampino, Mark Hyman Rapaport, Anna Rautanen, Abraham Reichenberg, Cheryl Roe, Joshua L. Roffman, Julian Roth, Matthias Rothermundt, Bart P. F. Rutten, Safaa Saker-Delye, Veikko Salomaa, Julio Sanjuán, Marcos Santoro, Adam Savitz, Ulrich Schall, Rodney J. Scott, Larry J. Seidman, Sally I. Sharp, Jianxin Shi, Larry J. Siever, Engilbert Sigurðsson, Kang Sim, Nora Skarabis, P. A. Slominsky, Hon‐Cheong So, Janet L. Sobell, Erik Söderman, Helen J. Stain, Nils Eiel Steen, Agnes A. Steixner-Kumar, Elisabeth Stögmann, William S. Stone, Richard E. Straub, Fabian Streit, Eric Strengman, T. Scott Stroup, Mythily Subramaniam, Catherine A. Sugar, Jaana Suvisaari, Dragan M. Švrakić, Neal R. Swerdlow, Jin Szatkiewicz, Thi Minh Tam Ta, Atsushi Takahashi, Chikashi Terao, Florence Thibaut, Драга Тончева, Paul A. Tooney, Silvia Torretta, Sarah Tosato, G.B. Tura, Bruce I. Turetsky, Alp Üçok, Arne E. Vaaler, Thérèse van Amelsvoort, Ruud van Winkel, Juha Veijola, John L. Waddington, Henrik Walter, Anna Waterreus, Bradley T. Webb, Mark Weiser, Nigel Williams, Stephanie H. Witt, Brandon K. Wormley, Jing Qin Wu, Zhida Xu, Robert H. Yolken, Clement C. Zai, Wei Zhou, Feng Zhu, Fritz Zimprich,
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic ...
Nature Portfolio
Helene Roelofs, Ruud J. H. L. M. van Gurp, J. Wolter Oosterhuis, Leendert H. J. Looijenga,
... sac tumor and choriocarcinoma (extraembryonic tissues).4Andrews PW Casper J Damjanov I Duggan-Keen M Giwercman A ... both by clinical and experimental findings.4Andrews PW Casper J Damjanov I Duggan-Keen M Giwercman A ...
Tópico(s): Chromosomal and Genetic Variations
1998 - Elsevier BV | American Journal Of Pathology
Diana A. van der Plaat, Judith M. Vonk, Natalie Terzikhan, Kim de Jong, Maaike de Vries, Sacha la Bastide‐van Gemert, Cleo C. van Diemen, Lies Lahousse, Guy Brusselle, Ivana Nedeljković, Najaf Amin, Bastiaan T Heijmans, Peter A.C. ‘t Hoen, Joyce B. J. van Meurs, Aaron Isaacs, Rick Jansen, Lude Franke, Dorret I. Boomsma, René Pool, Jenny van Dongen, Jouke‐Jan Hottenga, Marleen M. J. van Greevenbroek, Coen D.A. Stehouwer, Carla Kallen, Casper G. Schalkwijk, Cisca Wijmenga, Lude Franke, Sasha Zhernakova, Ettje F. Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana van Heemst, Jan H. Veldink, Leonard H. van den Berg, Cornelia M. van Duijn, Bert A. Hofman, Aaron Isaacs, André G. Uitterlinden, Joyce B. J. van Meurs, P. Mila Jhamai, Michaël Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha V. Zhernakova, Rick Jansen, Peter van’t Hof, Patrick Deelen, Irene Nooren, Peter A.C. ‘t Hoen, Bastiaan T Heijmans, Matthijs Moed, Lude Franke, Martijn Vermaat, Dasha V. Zhernakova, René Luijk, Marc Jan Bonder, Maarten van Iterson, Patrick Deelen, Freerk van Dijk, Michiel van Galen, Wibowo Arindrarto, Szymon M. Kiełbasa, Morris A. Swertz, Erik W. van Zwet, Rick Jansen, Peter-Bram’t Hoen, Bastiaan T Heijmans, Bastiaan T. Heijmans, Peter A.C. ‘t Hoen, Joyce B. J. van Meurs, Aaron Isaacs, Rick Jansen, Lude Franke, Dorret I. Boomsma, René Pool, Jenny van Dongen, Jouke‐Jan Hottenga, Marleen M. J. van Greevenbroek, Coen D.A. Stehouwer, Carla Kallen, Casper G. Schalkwijk, Cisca Wijmenga, Lude Franke, Sasha Zhernakova, Ettje F. Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana van Heemst, Jan H. Veldink, Leonard H. van den Berg, Cornelia M. van Duijn, Bert A. Hofman, Aaron Isaacs, André G. Uitterlinden, Joyce B. J. van Meurs, P. Mila Jhamai, Michaël Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha V. Zhernakova, Rick Jansen, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Peter A.C. ‘t Hoen, Bastiaan T. Heijmans, Matthijs Moed, Lude Franke, Martijn Vermaat, Dasha V. Zhernakova, René Luijk, Marc Jan Bonder, Maarten van Iterson, Patrick Deelen, Freerk van Dijk, Michiel van Galen, Wibowo Arindrarto, Szymon M. Kiełbasa, Morris A. Swertz, Erik W. van Zwet, Rick Jansen, Peter A.C. ‘t Hoen, Bastiaan T Heijmans, Hans Kromhout, Roel Vermeulen, Dirkje S. Postma, Cornelia M. van Duijn, H. Marike Boezen,
Abstract Many workers are daily exposed to occupational agents like gases/fumes, mineral dust or biological dust, which could induce adverse health effects. Epigenetic mechanisms, such as DNA methylation, have been suggested to play a role. We therefore aimed to identify differentially methylated regions (DMRs) upon occupational exposures in never-smokers and investigated if these DMRs associated with gene expression levels. To determine the effects of occupational exposures independent of smoking, ...
Tópico(s): Energy and Environment Impacts
2019 - Oxford University Press | Human Molecular Genetics
Produção Nacional
Revisado por pares
Melinda Mills, Felix C. Tropf, David M. Brazel, Natalie R. van Zuydam, Ahmad Vaez, Mawussé Agbessi, Habibul Ahsan, Isabel Alves, Anand Kumar Andiappan, Wibowo Arindrarto, Philip Awadalla, Alexis Battle, Frank Beutner, Marc Jan Bonder, Dorret I. Boomsma, Mark Christiansen, Annique Claringbould, Patrick Deelen, Tõnu Esko, Marie-Julie Favé, Lude Franke, Timothy M. Frayling, Sina A. Gharib, Greg Gibson, Bastiaan T. Heijmans, Gibran Hemani, Rick Jansen, Mika Kähönen, Anette Kalnapenkis, Silva Kasela, Johannes Kettunen, Yungil Kim, Holger Kirsten, Péter Kovács, Knut Krohn, Jaanika Kronberg, Viktorija Kukushkina, Zoltán Kutalik, Bernett Lee, Terho Lehtimäki, Markus Loeffler, Urko M. Marigorta, Hailang Mei, Lili Milani, Grant W. Montgomery, Martina Müller‐Nurasyid, Matthias Nauck, Michel G. Nivard, Brenda W.J.H. Penninx, Markus Perola, Natalia Pervjakova, Brandon L. Pierce, Joseph E. Powell, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Samuli Ripatti, Olaf Rötzschke, Sina Rüeger, Ashis Saha, Markus Scholz, Katharina Schramm, Ilkka Seppälä, P. Eline Slagboom, Coen D.A. Stehouwer, Michael Stümvoll, Patrick Sullivan, Peter A.C. ‘t Hoen, Alexander Teumer, Joachim Thiery, Tong Lin, Anke Tönjes, Jenny van Dongen, Maarten van Iterson, Joyce B. J. van Meurs, Jan H. Veldink, Joost Verlouw, Peter M. Visscher, Uwe Völker, Urmo Võsa, Harm-Jan Westra, Cisca Wijmenga, Hanieh Yaghootkar, Jian Yang, Biao Zeng, Futao Zhang, Bastiaan T. Heijmans, Peter A.C. ‘t Hoen, Joyce B. J. van Meurs, Aaron Isaacs, Rick Jansen, Lude Franke, Dorret I. Boomsma, René Pool, Jenny van Dongen, Jouke‐Jan Hottenga, Marleen M. J. van Greevenbroek, Coen D.A. Stehouwer, Carla Kallen, Casper G. Schalkwijk, Cisca Wijmenga, Lude Franke, Sasha Zhernakova, Ettje F. Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana van Heemst, Jan H. Veldink, Leonard H. van den Berg, Cornelia M. van Duijn, Bert A. Hofman, Aaron Isaacs, André G. Uitterlinden, Joyce B. J. van Meurs, P. Mila Jhamai, Michaël Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha V. Zhernakova, Rick Jansen, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Peter A.C. ‘t Hoen, Bastiaan T. Heijmans, Matthijs Moed, Lude Franke, Martijn Vermaat, Dasha V. Zhernakova, René Luijk, Marc Jan Bonder, Maarten van Iterson, Patrick Deelen, Freerk van Dijk, Michiel van Galen, Wibowo Arindrarto, Szymon M. Kiełbasa, Morris A. Swertz, Erik W. van Zwet, Rick Jansen, Peter A.C. ‘t Hoen, Bastiaan T. Heijmans, Evelina T. Akimova, Sven Bergmann, Jason D. Boardman, Dorret I. Boomsma, Marco Brumat, Julie E. Buring, David Cesarini, Daniel I. Chasman, Jorge E. Chavarro, Massimiliano Cocca, Maria Pina Concas, George Davey Smith, Gail Davies, Ian J. Deary, Tõnu Esko, Oscar H. Franco, Audrey J. Gaskins, Eco J. C. de Geus, Christian Gieger, Giorgia Girotto, Hans J. Grabe, Erica P. Gunderson, Kathleen Mullan Harris, Fernando Pires Hartwig, Chunyan He, Diana van Heemst, W. David Hill, Georg Homuth, Bernando Lessa Horta, Jouke‐Jan Hottenga, Hongyang Huang, Elina Hyppönen, M. Arfan Ikram, Rick Jansen, Magnus Johannesson, Zoha Kamali, Maryam Kavousi, Peter Kraft, Brigitte Kühnel, Claudia Langenberg, Penelope A. Lind, Jian’an Luan, Reedik Mägi, Patrik K. E. Magnusson, Anubha Mahajan, Nicholas G. Martin, Hamdi Mbarek, Mark I. McCarthy, George McMahon, Matthew B. McQueen, Sarah E. Medland, Thomas Meitinger, Andres Metspalu, Evelin Mihailov, Lili Milani, Stacey A. Missmer, Stine Møllegaard, Dennis O. Mook‐Kanamori, Anna Morgan, Peter J. van der Most, Renée de Mutsert, Matthias Nauck, Ilja M. Nolte, Raymond Noordam, Brenda W.J.H. Penninx, Annette Peters, Chris Power, Paul Redmond, Janet W. Rich‐Edwards, Paul M. Ridker, Cornelius A. Rietveld, Susan M. Ring, Lynda M. Rose, Rico Rueedi, Kári Stéfansson, Doris Stöckl, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Guðmar Þorleifsson, Unnur Þorsteinsdóttir, Roy Thurik, Nicholas J. Timpson, Constance Turman, André G. Uitterlinden, Mélanie Waldenberger, Nicholas J. Wareham, Gonneke Willemsen, Jing Zhao, Tune H. Pers, Harold Snieder, John R. B. Perry, Ken K. Ong, Marcel den Hoed, Nicola Barban, Felix R. Day,
Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the genetics of reproductive ...
Tópico(s): Ovarian function and disorders
2021 - Nature Portfolio | Nature Human Behaviour
Jenny van Dongen, Fiona A. Hagenbeek, Matthew Suderman, Peter J. Roetman, Karen Sugden, Andreas G. Chiocchetti, Khadeeja Ismail, Rosa H. Mulder, Jonathan D. Hafferty, Mark J. Adams, Rosie M. Walker, Stewart W. Morris, Jari Lahti, Leanne K. Küpers, Geòrgia Escaramís, Silvia Alemany, Marc Jan Bonder, M. Meijer, Hill F. Ip, Rick Jansen, Bart M. L. Baselmans, Priyanka Parmar, Estelle Lowry, Fabian Streit, Lea Sirignano, Tabea Send, Josef Frank, Juulia Jylhävä, Yunzhang Wang, Pashupati P. Mishra, Olivier F. Colins, David L. Corcoran, Richie Poulton, Jonathan Mill, Eilís Hannon, Louise Arseneault, Tellervo Korhonen, Eero Vuoksimaa, Janine F. Felix, Marian J. Bakermans‐Kranenburg, Archie Campbell, Darina Czamara, Elisabeth B. Binder, Eva Corpeleijn, Juan R. González, Regina Gražulevičienė, Kristine B. Gützkow, Jorunn Evandt, Marina Vafeiadi, Marieke Klein, Dennis van der Meer, Lannie Ligthart, Bastiaan T. Heijmans, Peter A.C. ‘t Hoen, Joyce B. J. van Meurs, Rick Jansen, Lude Franke, Dorret I. Boomsma, René Pool, Jenny van Dongen, Jouke‐Jan Hottenga, Marleen M. J. van Greevenbroek, Coen D.A. Stehouwer, Carla Kallen, Casper G. Schalkwijk, Cisca Wijmenga, Lude Franke, Alexandra Zhernakova, Ettje F. Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana van Heemst, Jan H. Veldink, Leonard H. van den Berg, Cornelia M. van Duijn, Bert A. Hofman, Aaron Isaacs, André G. Uitterlinden, Joyce B. J. van Meurs, P. Mila Jhamai, Michaël Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha V. Zhernakova, Rick Jansen, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Peter A.C. ‘t Hoen, Bastiaan T. Heijmans, Matthijs Moed, Lude Franke, Martijn Vermaat, Dasha V. Zhernakova, René Luijk, Marc Jan Bonder, Maarten van Iterson, Patrick Deelen, Freerk van Dijk, Michiel van Galen, Wibowo Arindrarto, Szymon M. Kiełbasa, Morris A. Swertz, Erik W. van Zwet, Rick Jansen, Peter A.C. ‘t Hoen, Bastiaan T. Heijmans, Cornelis Kluft, Gareth E. Davies, Christian Hakulinen, Liisa Keltikangas‐Järvinen, Barbara Franke, Christine M. Freitag, Kerstin Konrad, Amaia Hervás, Aranzazu Fernández‐Rivas, Ágnes Vetró, Olli Raitakari, Terho Lehtimäki, Robert Vermeiren, Timo Strandberg, Katri Räikkönen, Harold Snieder, Stephanie H. Witt, Michael Deuschle, Nancy L. Pedersen, Sara Hägg, Jordi Sunyer, Lude Franke, Jaakko Kaprio, Miina Ollikainen, Terrie E. Moffitt, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Martine Vrijheid, Sylvain Sebért, Marjo‐Riitta Järvelin, Avshalom Caspi, Kathryn L. Evans, Andrew M. McIntosh, Meike Bartels, Dorret I. Boomsma,
Abstract DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior ( N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1. ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2021 - Springer Nature | Molecular Psychiatry