
Alexandre de Matos Soeiro, Pedro Gabriel Melo de Barros e Silva, Eduardo Alberto de Castro Roque, Aline Siqueira Bossa, Bruno Biselli, Tatiana de Carvalho Andreucci Torres Leal, Maria Carolina Feres de Almeida Soeiro, Fábio Grunspun Pitta, Carlos Serrano, Múcio Tavares de Oliveira,
Background: Gender-related differences have been reported in patients with acute coronary syndrome. The description of this comparative finding in a Brazilian registry has not yet been documented. Objective: To compare male vs. female patients regarding the baseline characteristics, coronary findings, treatment and in-hospital and long-term prognosis. Methods: This is a retrospective, multicenter and observational study that included 3,745 patients (2,437 males and 1,308 females) between May 2010 ...
Tópico(s): Cardiac Health and Mental Health
2018 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia

Nuno Castelhano, Fabiana Caetano Martins Silva e Dutra, Márcia Bastos Rezende, Licínio Roque, Lívia de Castro Magalhães,
Abstract This article aims to document the use of multisensory stimulation environments and its related perceptions, concerning ludic content, play and the computer‐mediated ludic activity, from the perspective of professionals organizing and delivering therapeutic activities in these spaces with children with developmental disabilities, in Portugal. Face‐to‐face open interviews with 12 professionals working in multisensory stimulation environments, selected by convenience criteria, were individually ...
Tópico(s): Occupational Therapy Practice and Research
2013 - Hindawi Publishing Corporation | Occupational Therapy International

Alexandre de Matos Soeiro, Pedro Gabriel Melo de Barros e Silva, Eduardo Alberto de Castro Roque, Aline Siqueira Bossa, Maria Cristina César, Sheila Aparecida Simões, Mariana Yumi Okada, Tatiana de Carvalho Andreucci Torres Leal, Fátima Cristina Monteiro Pedroti, Múcio Tavares de Oliveira,
Background: Recent studies have shown fondaparinux's superiority over enoxaparin in patients with non-ST elevation acute coronary syndrome (ACS), especially in relation to bleeding reduction. The description of this finding in a Brazilian registry has not yet been documented. Objective: To compare fondaparinux versus enoxaparin in in-hospital prognosis of non-ST elevation ACS. Methods: Multicenter retrospective observational study. A total of 2,282 patients were included (335 in the fondaparinux group, ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2016 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia

Alexandre de Matos Soeiro, Pedro Gabriel Melo de Barros e Silva, Eduardo Alberto de Castro Roque, Aline Siqueira Bossa, Cindel Nogueira Zullino, Sheila Aparecida Simões, Mariana Yumi Okada, Tatiana de Carvalho Andreucci Torres Leal, Maria Carolina Feres de Almeida Soeiro, Carlos Serrano, Múcio Tavares de Oliveira,
OBJECTIVES: Recent studies have revealed a relationship between beta-blocker use and worse prognosis in acute coronary syndrome, mainly due to a higher incidence of cardiogenic shock.However, the relevance of this relationship in the reperfusion era is unknown.The aim of this study was to analyze the outcomes of patients with acute coronary syndrome that started oral beta-blockers within the first 24 hours of hospital admission (group I) compared to patients who did not use oral beta-blockers in ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2016 - Elsevier BV | Clinics

Larissa Roque Monteiro De Castro, Gabriele Fialho Silveira, Isadora Assis Caiado Fraga, Luiza Pimenta Lima Santos, Paula Andrade Ferreira, Adirson Monteiro De Castro,
Objetivo: Avaliar e revisar a correlação imune da disbiose na progressão do câncer de mama (CM). Revisão bibliográfica: A flora bacteriana contribui positivamente para as funções nutritivas, imunomoduladoras e metabólicas do organismo, entretanto possui um equilíbrio que se interrompido pode resultar em consequências sistêmicas, incluindo efeitos pró-carcinogênicos. Existe relação comprovada do microbioma intestinal em equilíbrio e da manutenção da saúde do hospedeiro, não apenas por interações ...
Tópico(s): Women's cancer prevention and management
2021 - Revista Eletronica Acervo Saude | Revista Eletrônica Acervo Saúde

Tiago Lazzaretti Fernandes, Flávio de Castro Magalhães, Fernanda Roberta Roque, M. Ian Phillips, Edilamar Menezes de Oliveira,
Aerobic exercise training (ET) lowers hypertension and improves patient outcomes in cardiovascular disease. The mechanisms of these effects are largely unknown. We hypothesized that ET modulates microRNAs (miRNAs) involved in vascularization. miRNA-16 regulates the expression of vascular endothelial growth factor and antiapoptotic protein Bcl-2. miRNA-21 targets Bcl-2. miRNA-126 functions by repressing regulators of the vascular endothelial growth factor pathway. We investigated whether miRNA-16, - ...
Tópico(s): Cardiovascular Disease and Adiposity
2012 - Lippincott Williams & Wilkins | Hypertension

Júlia Machado Khoury, André Augusto Corrêa de Freitas, Marco Antônio Valente Roque, Maicon Rodrigues Albuquerque, Maila de Castro Lourenço das Neves, Fréderico Duarte Garcia,
To translate, adapt and validate the Smartphone Addiction Inventory (SPAI) in a Brazilian population of young adults.We employed the translation and back-translation method for the adaptation of the Brazilian version SPAI (SPAI-BR). The sample consisted of 415 university students. Data was collected through an electronic questionnaire, which consisted of the SPAI-BR and the Goodman Criteria (gold standard). The retests were carried out 10-15 days after the initial tests with 130 individuals.The SPAI- ...
Tópico(s): Digital Marketing and Social Media
2017 - Public Library of Science | PLoS ONE

Tiago Fernandes, Juliana Sanajotti Nakamuta, Flávio de Castro Magalhães, Fernanda Roberta Roque, Carolina Lavini‐Ramos, Isolmar Tadeu Schettert, Verônica Coelho, José Eduardo Krieger, Edilamar Menezes de Oliveira,
Aerobic exercise training has been established as an important nonpharmacological treatment for hypertension. We investigated whether the number and function of endothelial progenitor cells (EPCs) are restored after exercise training, potentially contributing to neovascularization in hypertension.Twelve-week-old male spontaneously hypertensive rats (SHRs, n = 14) and Wistar-Kyoto (WKY, n = 14) rats were assigned to four groups: SHR; trained SHR (SHR-T); WKY; and trained WKY. Exercise training consisted ...
Tópico(s): Cardiovascular Health and Disease Prevention
2012 - Lippincott Williams & Wilkins | Journal of Hypertension

José Sidney Roque, Karina Torres Pomini, Rogério Leone Buchaim, Daniela Vieira Buchaim, Jesús Carlos Andreo, Domingos Donizeti Roque, Antônio de Castro Rodrigues, Geraldo Marco Rosa, Luis Henrique Rapucci Moraes, Fausto Viterbo,
Purpose: To evaluated the tubulization technique with standard and inside-out vein, filled or not with platelet-rich plasma (PRP), in sciatic nerve repair. Methods: Seventy male Wistar rats were randomly divided into five groups: IOVNF (Inside-Out Vein with No Filling); IOVPRP (Inside-Out Vein filled with PRP); SVNF (Standard Vein with No Filling); SVPRP (Standard Vein filled with PRP); Sham (Control). The left external jugular vein was used as graft in a 10 mm nervous gap. Results: In the morphological ...
Tópico(s): Peripheral Nerve Disorders
2017 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira

Luiz C. Caires-Júnior, Ernesto Goulart, Uirá Souto Melo, Bruno Henrique Silva Araújo, Lucas Alvizi, Alessandra Soares‐Schanoski, Danyllo Oliveira, Gerson Shigeru Kobayashi, Karina Griesi‐Oliveira, Camila Manso Musso, Murilo Sena Amaral, Lucas F. daSilva, Renato Mancini Astray, Sandra Fernanda Suárez-Patiño, Daniella C. Ventini, Sérgio Gomes da Silva, Guilherme Lopes Yamamoto, Suzana Ezquina, Michel Satya Naslavsky, Kayque A. Telles-Silva, Karina Weinmann, Vanessa van der Linden, Hélio van der Linden, João Ricardo Mendes de Oliveira, Nívia Maria Rodrigues Arrais, Adriana Suely de Oliveira Melo, Thalita Figueiredo, Silvana Santos, Joanna Góes Castro Meira, Saulo Duarte Passos, Roque Pacheco de Almeida, Ana Jovina Barreto Bispo, Ésper A. Cavalheiro, Jorge Kalil, Edécio Cunha‐Neto, Helder I. Nakaya, Robert Andreata‐Santos, Luís Carlos de Souza Ferreira, Sergio Verjovski‐Almeida, Paulo Lee Ho, Maria Rita Passos‐Bueno, Mayana Zatz,
Abstract Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the NPCs from CZS babies show a significantly different gene expression signature of mTOR and Wnt pathway regulators, key to a neurodevelopmental program. Following ZIKV in vitro ...
Tópico(s): Viral Infections and Vectors
2018 - Nature Portfolio | Nature Communications

Júlia Machado Khoury, Maila de Castro Lourenço das Neves, Marco Antônio Valente Roque, Daniela Alves de Brito Queiroz, André Augusto Corrêa de Freitas, Ângelo de Fátima, Fabrício A. Moreira, Fréderico Duarte Garcia,
Objectives: Understanding whether cannabidiol (CBD) is useful and safe for the treatment of psychiatric disorders is essential to empower psychiatrists and patients to take good clinical decisions. Our aim was to conduct a systematic review regarding the benefits and adverse events (AEs) of CBD in the treatment of schizophrenia, psychotic disorders, anxiety disorders, depression, bipolar disorder and substance-use disorders.Methods: We conducted a literature search in PubMed, Scielo, and Clinicaltrials. ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2017 - Taylor & Francis | The World Journal of Biological Psychiatry

Júlia Machado Khoury, Maila de Castro Lourenço das Neves, Marco Antônio Valente Roque, André Augusto Corrêa de Freitas, Michele Ralil da Costa, Fréderico Duarte Garcia,
To improve the comprehension of the interface between smartphone addiction (SA) and Facebook addiction (FA), we hypothesize that the occurrence of both technological addictions correlate, with higher levels of negative consequences. Moreover, we hypothesize that SA is associated with lower levels of social support satisfaction.We recruited a convenience sample of undergraduate students from Universidade Federal de Minas Gerais, with age ranging between 18 and 35 years. All subjects completed a self- ...
Tópico(s): Child Development and Digital Technology
2019 - Associação de Psiquiatria do Rio Grande do Sul | Trends in Psychiatry and Psychotherapy
Roque Aguado, Ginés A. de Gea, José Manuel Castro Jiménez, Luis O’Dogherty, M. L. Quijano, B. David A. Naafs, Richard D. Pancost,
In order to determine the driving mechanism behind the deposition of the Aptian dark facies in the pelagic Subbetic Basin (southern Spain), two latest Barremian–early Aptian complementary sections embracing the Oceanic Anoxic Event 1a, were selected for a multidisciplinary study. Quantitative and statistical analyses of calcareous nannofossil assemblages are complemented with planktonic foraminifera, radiolaria, and geochemical data (C and O isotopes and biomarkers). The results indicate that most ...
Tópico(s): Geological formations and processes
2014 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology

Lucas Fornari Laurindo, Jefferson Aparecido Dias, Adriano Cressoni Araújo, Karina Torres Pomini, Cristiano Machado Galhardi, Cláudia Rucco Penteado Detregiachi, Luíza Santos de Argollo Haber, Domingos Donizeti Roque, Marcelo Dib Bechara, Marcela Vialogo Marques de Castro, Eliana de Souza Bastos Mazuqueli Pereira, Ricardo José Tofano, Iris Jasmin Santos German Borgo, Sandra Maria Barbalho,
The increasing life expectancy has led to a higher incidence of age-related neurodegenerative conditions. Within this framework, neuroinflammation emerges as a significant contributing factor. It involves the activation of microglia and astrocytes, leading to the release of pro-inflammatory cytokines and chemokines and the infiltration of peripheral leukocytes into the central nervous system (CNS). These instances result in neuronal damage and neurodegeneration through activated nucleotide-binding ...
Tópico(s): Tryptophan and brain disorders
2024 - Frontiers Media | Frontiers in Immunology
Roque Aguado, José Manuel Castro Jiménez, Miguel Company, Ginés A. de Gea,
The Upper Barremian to Aptian Almadich Formation (Inner Prebetic Domain of the Betic Cordillera) is composed of hemipelagic sediments deposited on a distal carbonate ramp in the southern Iberian Palaeomargin. Within this facies we have found a thick interval of blue to black shales and marls that is interpreted as deposited under oxygen-depleted conditions. We think that this interval, dated as early Aptian, represents the local record of Ocean Anoxic Event 1a. The integrated biostratigraphic analysis ...
Tópico(s): Geological formations and processes
1999 - Elsevier BV | Cretaceous Research
Roque Aguado, Miguel Company, José Manuel Castro Jiménez, Ginés A. de Gea, José Miguel Molina, Luís M. Nieto, Pedro A. Ruiz‐Ortiz,
Tópico(s): Paleontology and Stratigraphy of Fossils
2018 - Elsevier BV | Cretaceous Research

Sandro de Castro Pitano, Bianca Beatriz Roqué,
The research analysed the design of the graduate students of the BSc in Geography of the Federal University of Rio Grande (FURG), members of the Institutional Scholarship Program for Initiation to Teaching (PIBID) on the use of scale models as a resource in the teachinglearning process. The empirical research was evaluated in three stages during development: the first one sought to highlight the preconception group; the second workshop implemented the models; and the third used the scale model in ...
Tópico(s): Environmental Sustainability and Education
2015 - UNIVERSIDADE DO VALE DO RIO DOS SINOS | Educação Unisinos

Bianca Cr de Castro, Heraldo Lorena Guida, Adriano L. Roque, Luíz Carlos de Abreu, Lucas Lima Ferreira, Rodrigo Daminello Raimundo, Carlos Bandeira de Mello Monteiro, Flávia C Goulart, Celso Ferreira, Renata S. Marcomini, Vivian Finotti Ribeiro, Alessandro Hn Ré, Luiz Carlos Marques Vanderlei, Vítor Engrácia Valenti,
Chronic exposure to musical auditory stimulation has been reported to improve cardiac autonomic regulation. However, it is not clear if music acutely influences it in response to autonomic tests. We evaluated the acute effects of music on heart rate variability (HRV) responses to the postural change maneuver (PCM) in women.We evaluated 12 healthy women between 18 and 28 years old and HRV was analyzed in the time (SDNN, RMSSD, NN50 and pNN50) and frequency (LF, HF and LF/HF ratio) domains. In the control ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2013 - International Medical Society | International Archives of Medicine

Tiago Lazzaretti Fernandes, Fernanda Roberta Roque, Flávio de Castro Magalhães, Everton Crívoi do Carmo, Edilamar Menezes de Oliveira,
O treinamento físico (TF) aeróbio tem sido utilizado como um importante tratamento não farmacológico na hipertensão arterial (HA), uma vez que ele reduz a pressão arterial. Estudos mostram que as anormalidades do músculo esquelético na HA estão associados à rarefação capilar, um aumento na porcentagem de fibras de contração rápida (tipo II), com predominância do metabolismo glicolítico e um aumento da fadiga muscular. Entretanto, pouco se conhece sobre os efeitos do TF sobre estes parâmetros na HA. ...
Tópico(s): Physical Activity and Health
2012 - Sociedade Brasileira de Medicina do Esporte | Revista Brasileira de Medicina do Esporte
Catarina S. Roque, Mariana de Castro, Tarsila G. Castro, Carla Silva, Artur Cavaco‐Paulo, Jennifer Noro,
Abstract Using lipases to catalyze the synthesis of the most differentiated type of compounds remains one of the major challenges among scientists. Seeking more economic and advantageous catalysts is a current goal of green chemistry. In this work, we demonstrate the potential of a chemically modified form of lipase from Thermomyces lanuginosus (cmLTL) for the synthesis of both hydrophobic (heptyl heptanoate, heptyl octanoate, heptyl decanoate, decyl heptanoate, decyl octanoate and decyl decanoate) ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2024 - Wiley | ChemBioChem
Ginés A. de Gea, Roque Aguado, José Manuel Castro Jiménez, José Miguel Molina, Luis O’Dogherty, Pedro A. Ruiz‐Ortiz,
The Carbonero Formation represents a scarce, well documented example of Aptian anoxic facies in the Betic Cordillera. Generally, the Aptian record in the pelagic Subbetic basin is both very discontinuous and affected by frequent hiatuses, but in some subsident areas controlled by extensional faults (as in the Carbonero trough) an interesting record is preserved. The Carbonero Formation is characterised by a thick pelagic succession composed of marls with intercalations of calcareous turbidites and ...
Tópico(s): Geological formations and processes
2008 - Elsevier BV | Cretaceous Research

Janir Alves Soares, Maria Auxiliadora Roque de Carvalho, Suelleng Maria Cunha Santos, Rafael Mangerotti Castro Mendonça, Antônio Paulino Ribeiro Sobrinho, Manoel Brito-Júnior, Paula Prazeres Magalhães, Maria Helena Santos, Luiz de Mácêdo Farias,
Introduction The elimination of microorganisms from root canals is a critical step in endodontic treatment. We aimed to evaluate the antimicrobial effectiveness of an alternating irrigation regimen during chemomechanical preparation (CMP). Methods During 21 days, root canals of extracted human teeth were infected with Enterococcus faecalis, and colonization was confirmed by scanning electron microscopy (SEM). Canals were irrigated with saline solution (control group), with 5.25% NaOCl followed by a ...
Tópico(s): Dental Radiography and Imaging
2010 - Elsevier BV | Journal of Endodontics

Lia Maristela da Silva Jacob, Márcio Cristiano de Melo, Rômulo Mágnus de Castro Sena, Isaac Jacob da Silva, Reginaldo Roque Mafetoni, Kellen Cristina Silva de Souza,
Objetivo: identificar e descrever as evidências científicas sobre as ações educativas realizadas no programa Saúde na Escola. Método: revisão integrativa realizada nos meses de julho e agosto de 2018, em bases de dados eletrônicas com tradição em publicações na área da saúde. Resultados: o levantamento resultou em 12 artigos incluídos abordando os seguintes eixos: Estudo cartográfica na escola, uso de web rádio com escolares, conhecimento de escolares sobre poluição, percepções de educadores sobre ...
Tópico(s): Public Health and Nutrition
2019 - UNIVERSIDADE CESUMAR | Saúde e Pesquisa

Heloísa D’Ávila, Patrícia E. de Almeida, Natália R. Roque, Hugo C. Castro‐Faria‐Neto, Patrı́cia T. Bozza,
ABSTRACT An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely ...
Tópico(s): Immune Cell Function and Interaction
2006 - American Society for Microbiology | Infection and Immunity

Maísa Soares dos Santos Lopes, Iago Pachêco Gomes, Roque Mendes Prado Trindade, Alzira F. da Silva, Antônio Cezar de Castro Lima,
Remote robotics laboratories have been successfully used for engineering education. However, few of them use mobile robots to to teach computer science. This article describes a mobile robot Control and Programming Environment (CPE) and its pedagogical applications. The system comprises a remote laboratory for robotics, an online programming tool, and a virtual learning environment. It allows experiments with a mobile robot to be carried out, tested and validated remotely, using a simple graphic ...
Tópico(s): Mechatronics Education and Applications
2016 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Learning Technologies
Ginés A. de Gea, José Manuel Castro Jiménez, Roque Aguado, Pedro A. Ruiz‐Ortiz, Miguel Company,
A δ13C curve is reported for the latest Barremian to Early Aptian at a section located in the Prebetic zone (Cau section, SE Spain). The studied section records a hemipelagic succession of dark shales, deposited on a distal carbonate ramp with a high subsidence rate, adjacent to shallow carbonate environments. The integrated biostratigraphy of the section is based on ammonites, planktonic foraminifera and calcareous nannofossils, and it has allowed an accurate dating of the succession. The δ13C curve ...
Tópico(s): Geological formations and processes
2003 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology
Elton Luiz Silva, Guilherme Carneiro, Lidiane Advíncula de Araújo, Mariana de Jesús, Vaz Trindade, María Irene Yoshida, Rodrigo Lambert Oréfice, Luis de Macêdo Farias, Maria Auxiliadora Roque de Carvalho, Simone Gonçalves dos Santos, Gisele Assis, Gisele Assis Castro Goulart, Ricardo José Alves, Lucas Antônio Miranda Ferreira,
Topical therapy is the first choice for the treatment of mild to moderate acne and all-trans retinoic acid is one of the most used drugs. The combination of retinoids and antimicrobials is an innovative approach for acne therapy. Recently, lauric acid, a saturated fatty acid, has shown strong antimicrobial activity against Propionibacterium acnes. However, topical application of retinoic acid is followed by high incidence of side-effects, including erythema and irritation. Solid lipid nanoparticles ...
Tópico(s): melanin and skin pigmentation
2014 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology

C. de Castro, Adônis Moreira, Ricardo Ferraz de Oliveira, Antônio Roque Dechen,
Com este trabalho, objetivou-se estudar sob condições de casa-de-vegetação, o efeito da interação doses boro e estresse hídrico na produção de matéria seca total, produção de aquênios e conteúdo de óleo em girassol cultivado em Latossolo Vermelho Amarelo distrófico de textura média. O delineamento experimental utilizado foi o de blocos ao acaso, em esquema fatorial 4 x 4, com quatro repetições. Foram estudadas quatro doses de B: 0, 0,25, 0,5 e 2,0 mg kg-1, aplicado na forma de ácido bórico e quatro ...
Tópico(s): Selenium in Biological Systems
2006 - UNIVERSIDADE FEDERAL DE LAVRAS | Ciência e Agrotecnologia
José Manuel Castro Jiménez, Miguel Company, Ginés A. de Gea, Roque Aguado,
The biostratigraphy of platform carbonates and adjacent basins outcropping in the Prebetic Zone of Alicante, south-eastern Spain, is presented. With this aim, 42 sections from 13 major outcrops, of Aptian–Middle Cenomanian age, were analysed. Ten biostratigraphic units based upon benthonic foraminifers have been distinguished within this interval. Comparison with other previously published biozonations shows, in general, a good agreement, but several differences have arisen, interpreted mainly to ...
Tópico(s): Geology and Paleoclimatology Research
2001 - Elsevier BV | Cretaceous Research
Julio A. Castro-Almazán, C. Muñoz–Tuñón, B. García‐Lorenzo, Gabriel Pérez-Jordán, A. M. Varela, Ignacio Romero,
We are presenting two years (2012 and 2013) of preliminary statistical results of calibrated PWV values from the GPS geodesic antennas (LPAL and IZAN) at Teide and Roque de los Muchachos Observatories (OT and ORM), Canary Islands. To calibrate the PWV from both GPS antennas we have selected a set of simultaneous high vertical resolution radio-sounding profiles from the closest operational balloon station, Güímar (GUI-WMO 60018; ≈15 km distant from OT and ≈150 km from ORM). The calibrations showed a correlation ...
Tópico(s): Ionosphere and magnetosphere dynamics
2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE