Pedro C. Cavadas, Alessandro Thioné, Margarita Blanes, Empar Mayordomo‐Aranda,
... Bilateral Transfemoral Lower Extremity Transplantation Recipient P. C. Cavadas, P. C. Cavadas Reconstructive Surgery Unit, Clinica Cavadas, Valencia, SpainSearch for more papers by this authorA. ... Corresponding Author A. Thione Reconstructive Surgery Unit, Clinica Cavadas, Valencia, Spain Corresponding author: Alessandro Thione, althione@gmail. ... for more papers by this author P. C. Cavadas, P. C. Cavadas Reconstructive Surgery Unit, Clinica Cavadas, Valencia, SpainSearch for more papers by this authorA. ...
Tópico(s): Viral-associated cancers and disorders
2015 - Elsevier BV | American Journal of Transplantation
Luis Landín, Pedro C. Cavadas, Peter Nthumba, Javier Maupoey, Francisco Vera‐Sempere,
... 2 to 3 years. Luis Landin Pedro C. Cavadas Clinica Cavadas, Plastic and Reconstructive Surgery Division “La Fe” University Hospital Valencia, Spain Peter Nthumba Clinica Cavadas Pedro Cavadas Foundation, “La Fe” University Hospital Valencia, Spain Javier Ibañez Clinica Cavadas, Plastic and Reconstructive Surgery Division “La Fe” University ...
Tópico(s): Reconstructive Surgery and Microvascular Techniques
2009 - Wolters Kluwer | Transplantation
Cláudia Cavadas, ANTÓNIO PEDRO SILVA, Maria Dulce Cotrim, Carlos Ribeiro, Hans R. Brunner, Eric Grouzmann,
... Response to KCl from Mice Chromaffin Cells CLÁUDIA CAVADAS, CLÁUDIA CAVADAS Laboratory of Pharmacology, Faculty of Pharmacy, University of ... Search for more papers by this author CLÁUDIA CAVADAS, CLÁUDIA CAVADAS Laboratory of Pharmacology, Faculty of Pharmacy, University of ... Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Cavadas, C. et al. 2001. Neuropeptide Y regulates catecholamine ...
Tópico(s): Pancreatic function and diabetes
2002 - Wiley | Annals of the New York Academy of Sciences
Cláudia Cavadas, Carlos Ribeiro, Maria Dulce Cotrim, François Mosimann, Hans R. Brunner, Eric Grouzmann,
... Chromaffin Cells Effect of Nicotine and KCl CLÁUDIA CAVADAS, CLÁUDIA CAVADAS Laboratory of Pharmacology, Faculty of Pharmacy, University of ... Search for more papers by this author CLÁUDIA CAVADAS, CLÁUDIA CAVADAS Laboratory of Pharmacology, Faculty of Pharmacy, University of ... Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Cavadas, C., A.P. Silva, F. Mosimann, et al. ...
Tópico(s): Receptor Mechanisms and Signaling
2002 - Wiley | Annals of the New York Academy of Sciences
Javier Rodríguez, Cameron D. Haydinger, Daniel J. Peet, Lan K. Nguyen, Alex von Kriegsheim,
... Fabrizio J.A. Nolan K.A. Spielmann P. Cavadas M.A. Crifo B. Halligan D.N. Nathan ... of the immediate HIF network (32Nguyen L.K. Cavadas M.A. Scholz C.C. Fitzpatrick S.F. ... pathway that we developed previously (32Nguyen L.K. Cavadas M.A. Scholz C.C. Fitzpatrick S.F. ...
Tópico(s): Advanced Proteomics Techniques and Applications
2020 - Elsevier BV | Molecular & Cellular Proteomics
Luis Landín, Pedro C. Cavadas, José Rodríguez-Pérez, Miguel Ángel García Bello, Pedro García-Cosmes, Alessandro Thioné, Francisco Vera‐Sempere, Luis Alfaro,
... Division University Hospital “La Fe” Valencia, Spain 2Clinica Cavadas Pedro Cavadas Foundation Valencia, Spain 3Nephrology Division Dr. Negrín University ...
Tópico(s): Transplantation: Methods and Outcomes
2010 - Wolters Kluwer | Transplantation
Luis Landín, Pedro C. Cavadas, Javier Ibáñez, Ignacio Roger,
... allograft surgeons. Luis Landin, M.D. Pedro C. Cavadas, M.D., Ph.D. Javier Ibañez, M.D. ... and Reconstructive Surgery Division; Hand Transplantation Team; Clínica Cavadas; "La Fe" University Hospital; Valencia, Spain DISCLOSURES None ...
Tópico(s): Reconstructive Facial Surgery Techniques
2009 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery
... 2002; revised April 22, 2002. Follow-up to Cavadas, P. C. Reversed saphenous neurocutaneous island flap: Clinical ... Plast. Reconstr. Surg. 99: 1910, 1997. Pedro C. Cavadas, M.D., Ph.D. Temple 5, 2 46003 ...
Tópico(s): Surgical Sutures and Adhesives
2003 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery
Produção Nacional
Taciane Barbosa Henriques, Diandra Zipinotti dos Santos, Isabella dos Santos Guimarães, Nayara Gusmão Tessarollo, Paulo Cilas Morais Lyra-Junior, Patrícia Mesquita, Diana Pádua, Ana Luísa Amaral, Bruno Cavadas, Luı́sa Pereira, Ian Victor Silva, Raquel Almeida, Letícia Batista Azevedo Rangel,
... Patricia Mesquita, Diana Pádua, Ana Luisa Amaral, Bruno Cavadas, Luisa Pereira, Ian Victor Silva, Raquel Maria da ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2021 - Impact Journals LLC | Aging
Stephen J. Chapman, Ruth Blanco‐Colino, S Pérez-Ajates, O Anabitarte Bautista, James Hodson, Ruth Blanco‐Colino, Stephen J. Chapman, James Glasbey, Francesco Pata, Gianluca Pellino, AS Soares, T. van Elst, Stephanie Van Straten, Dmitri Nepogodiev, James Hodson, Aditya Borakati, M F Bath, Ifat Yasin, Kenneth A McLean, Thomas Arthur, M Kovacević, S Delibegovic, Martin Karamanliev, Mohamed Swamad, R Žebrák, R Paramasivam, Anne Kraushaar Martensen, Helene Mathilde Larsen, Lukas Rädeker, Pia‐Elena Frey, Aristotelis Kechagias, Aurélien Venara, Émilie Duchalais, Argyrios Ioannidis, Francesco Pata, Gianluca Pellino, Sandro Pasquali, Andrea Simioni, Valeria Farina, Mauro Podda, Laura Lorenzon, ItSURG, V. Schaeff, Amy D. Otto, Matas Jakubauskas, T. R. van Elst, Michael J. J. Chu, Paul Fagan, Cameron I. Wells, A Alagoa João, António Sampaio Soares, Jovan Juloski, Ruth Blanco‐Colino, S Pérez-Ajates, O Anabitarte Bautista, Y. El Kasmy El Kasmi, Eloy Espín, Daniel Clerc, Cezar Ciubotaru, S S Popescu, A Yanishev, S Lee, Bahar Büşra Özkan, A Yagız Sen, M K Aktas, Bahadır Emre Baki, B Yüksek, James Glasbey, Sivesh K. Kamarajah, Kenneth A McLean, Aditya Borakati, Ifat Yasin, Rachel A Khaw, Emily Mills, R. Goodson, Nimish Thakral, Andrew D. Ablett, M Adra, I Kwek, S. Khan, Patrick Quinn, L R Manley, Abdul Badran, A Ramjeeawon, A Campbell, Haiyan Tan, Dupinderjit Rye, Nikitha Rajaraman, James G. Norman, Kritchai Vutipongsatorn, Georgios Solomou, Melika Akhbari, Ased Ali, B D Brandao, B Stainer, Rachel Thavayogan, D. Jones, Oluwatobi Onafowokan, A Gharooni, N Dabab, S Carlton-Carew, Garikai Kungwengwe, Melissa Gabriel, Emma Sewart, T Shortland, Samuel Lawday, Peter Pockney, Amanda Dawson, Peter Stewart, Benjamin Ng, Jason Luong, S Delibegovic, V. A. Ivanov, Anna V. Borisova, V Neykov, M Farkašová R Žebrák, J L Harbjerg, Søren Brandsborg, Anders Mark‐Christensen, K P Unbehaun, Peter Dalsgaard, Kathrine Dyhr Lycke, Aristotelis Kechagias, P LeNaoures, Émilie Duchalais, Cécile Brigand, E. Dumange, M Gout, C Moehwald, M Prem, Omar Alhalabi, S Sliwiński, Johannes Krupp, Eva Gablenz, L Schmitzer, A. Kopp, John G. Steinle, Julia Gsenger, L J Pohl, Mariagrazia Riccardi, I M Christodoulou, M. Konstantinidis, Nikolaos Machairas, Athanasios Zoikas, Dimitrios Balalis, Dimitrios K. Manatakis, M L Aguilera, Andrea Simioni, Luigi Marano, Francesco Fleres, Federico Lovisetto, Diego Sasia, Edoardo Segalini, Giacomo Pata, Andrea Lucchi, Andrea Sagnotta, Tommaso Campagnaro, Filippo Petrelli, Gaetano Gallo, Matteo Papandrea, Valentina Testa, Giovanni Sinibaldi, Francesca Di Candido, F. Colombo, Gennaro Perrone, S Aresu, Alessia Biancafarina, Giuseppe Canonico, Michele Pagnanelli, Gianluca Curletti, Roberto Bini, A De Manzoni Garberini, Harmony Impellizzeri, Nicola Cillara, Roberta Tutino, Arcangelo Picciariello, Diego Coletta, Gustavo Savino, Francesco Ferrara, Nicolò Tamini, Giuseppina Talamo, Dario Parini, P. Giamundo, Gennaro Pagano, V. Ripetti, Antonio Pesce, Nunzia Menduni, Gianluca Pellino, Rosina Giudicissi, Mauro Podda, Ehud Goldin, Daniela Rega, Antonio Belli, Valeria Andriola, Luca Gordini, Francesco Pata, Caterina Foppa, Gaetano Piccolo, Arianna Birindelli, Cecilia Ferrari, Zeno Ballarini, Flavio Tirelli, Marco Milone, Michele De Rosa, N S Pipitone Federico, Beatrice Molteni, Pier Luigi Tilocca, Giulio Sancini, Guglielmo Niccolò Piozzi, Andrea Lauretta, Silvia Mulas, V. Schaeff, Amy D. Otto, Matas Jakubauskas, Dainius Šimčikas, L Portelli, J. W. M. van Wijnbergen, T L Dinger, S. F. H. ten Doesschate, Anne Sophie H.M. van Dalen, D. D. van den Bos, Martin‐Leo Hansmann, J Medina Feliz, Sara Z. Kuiper, Ziena Abdulrahman, S R Pruijssers, V P Geneta, Michael J. J. Chu, Stephen B. Wilton, H Kandelaki, Shuang Peng, Simon Campbell, Yee-Wei Lim, Shahed Yassaie, Michael J. Murray, Paul Fagan, Cheyaanthan Haran, J Tan, João Pimenta de Castro, Álvaro Laranjeira, Susana O. Catarino, C Neves-Marques, J. G. Correia, Bárbara Vieira, Catarina Quintela, Marta Serra, J Maciel, Miguel F Cunha, David Aparício, José Farela Neves, José Azevedo, Manuela Romano, F Eiró, Joana Romano, Cristina Monteiro, M Claro, Almeida, Mariana Peyroteo, N D Machado, Hugo Capote, Margarida Ferreira, Xavier de Sousa, Helena Devesa, Demetrio Cavadas, I Guerreiro, Maria Laura Costa, Manuel Rosete, M Salman, C English, N Mohammed, S S Popescu, A Yanishev, Andrey Litvin, V Cuk, K Mészárosová, Stephanie Van Straten, Robert Jaich, Henrique Lima, Savannah Brooks, M. Marx, M Nshalati Salvation, Juan García Cardo, Ismael Mora‐Guzmán, Jorge Sancho Muriel, U De Andres Olabarria, Pablo Muriel, Clara Viñas, Felipe Alconchel, O Esteban Sinovas, Y. El Kasmy El Kasmi, C. Fairén Oro, S Pérez-Ajates, M. López Otero, S. Figueroa Jiménez, O. Claramonte Bellmunt, J Martínez Caballero,
Abstract Background Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between ...
Oxford University Press
Stephen J. Chapman, Daniel Clerc, Ruth Blanco‐Colino, Amy D. Otto, Dmitri Nepogodiev, Gennaro Pagano, V. Schaeff, António Sampaio Soares, G Zaffaroni, R Žebrák, James Hodson, Ruth Blanco‐Colino, Stephen J. Chapman, James Glasbey, P Pata, Gianluca Pellino, A Sgrò, António Sampaio Soares, T. R. van Elst, Stephanie Van Straten, Charles H. Knowles, Dmitri Nepogodiev, James Hodson, Aditya Borakati, M F Bath, Ifat Yasin, Kenneth A McLean, Thomas Arthur, M Kovacević, S Delibegovic, Martin Karamanliev, Mohamed Swamad, R Žebrák, R Paramasivam, Anne Kraushaar Martensen, Helene Mathilde Larsen, Lukas Rädeker, Pia‐Elena Frey, Aristotelis Kechagias, Aurélien Venara, Émilie Duchalais, Argyrios Ioannidis, Francesco Pata, Gianluca Pellino, Sandro Pasquali, A Sgrò, Andrea Simioni, Valeria Farina, Mauro Podda, Laura Lorenzon, V. Schaeff, Amy D. Otto, Matas Jakubauskas, T. R. van Elst, Michael J. J. Chu, Paul Fagan, Cameron I. Wells, A Alagoa João, António Sampaio Soares, Jovan Juloski, Daniel Clerc, Cezar Ciubotaru, S S Popescu, A Yanishev, S Lee, Bahar Büşra Özkan, A Yagız Sen, M K Aktas, Bahadır Emre Baki, B Yüksek, James Glasbey, Sivesh K. Kamarajah, Kenneth A McLean, Aditya Borakati, Ifat Yasin, Rachel A Khaw, Emily Mills, R. Goodson, Nimish Thakral, Andrew D. Ablett, M Adra, I Kwek, S. Khan, Patrick Quinn, L R Manley, Abdul Badran, A Ramjeeawon, A Campbell, H Tan, Dupinderjit Rye, Nikitha Rajaraman, James G. Norman, Kritchai Vutipongsatorn, Georgios Solomou, Melika Akhbari, A. Ali, Victoria Murray, Daniel Baker, B D Brandao, B Stainer, Rachel Thavayogan, D. Jones, Oluwatobi Onafowokan, A Gharooni, N Dabab, S Carlton-Carew, Garikai Kungwengwe, Melissa Gabriel, Emma Sewart, T Shortland, Samuel Lawday, Peter Pockney, Amanda Dawson, Thomas Arthur, C. D. Brumfitt, Peter Stewart, Benjamin Ng, Jason Luong, S Delibegovic, V. A. Ivanov, Anna V. Borisova, V Neykov, K. Kuncarová, Barbora Kološová, Tatyana I. Antonova, Martina Farkašová, R Žebrák, J L Harbjerg, Søren Brandsborg, S. Brinck, Mie Dilling Kjær, Anders Mark‐Christensen, K P Unbehaun, Peter Dalsgaard, Kathrine Dyhr Lycke, Aristotelis Kechagias, P LeNaoures, Émilie Duchalais, Cécile Brigand, E. Dumange, M Gout, C Moehwald, M Prem, Omar Alhalabi, S Sliwiński, Johannes Krupp, Eva Gablenz, L Schmitzer, A. Kopp, John G. Steinle, Julia Gsenger, L J Pohl, Mariagrazia Riccardi, I M Christodoulou, M. Konstantinidis, Nikolaos Machairas, Athanasios Zoikas, Dimitrios Balalis, Dimitrios K. Manatakis, María Lorena Aguilera, A Sgrò, Andrea Simioni, Luigi Marano, Francesco Fleres, Federico Lovisetto, Diego Sasia, Edoardo Segalini, Giacomo Pata, Andrea Lucchi, Andrea Sagnotta, Tommaso Campagnaro, Filippo Petrelli, Gaetano Gallo, Mary-Rose Papandrea, Valentina Testa, Giovanni Sinibaldi, Francesca Di Candido, F. Colombo, Gennaro Perrone, S Aresu, Alessia Biancafarina, Giuseppe Canonico, Michele Pagnanelli, Gianluca Curletti, Roberto Bini, A Manzoni Garberini, Harmony Impellizzeri, Nicola Cillara, Roberta Tutino, Arcangelo Picciariello, Diego Coletta, Gustavo Savino, Francesco Ferrara, Nicolò Tamini, Giuseppina Talamo, Dario Parini, P. Giamundo, Angela Conte, Gennaro Pagano, V. Ripetti, Antonio Pesce, Nunzia Menduni, Gianluca Pellino, Rosina Giudicissi, Mauro Podda, Ehud Goldin, Daniela Rega, Antonio Belli, Valeria Andriola, Luca Gordini, Francesco Pata, Caterina Foppa, Gaetano Piccolo, Arianna Birindelli, Cecilia Ferrari, Zeno Ballarini, Flavio Tirelli, Marco Milone, Michele De Rosa, N S Pipitone Federico, Beatrice Molteni, Pier Luigi Tilocca, Giulio Sancini, Guglielmo Niccolò Piozzi, Andrea Lauretta, Gaetano Poillucci, Silvia Mulas, V. Schaeff, Amy D. Otto, Matas Jakubauskas, Dainius Šimčikas, L Portelli, J. W. M. van Wijnbergen, T L Dinger, S. F. H. ten Doesschate, Anne Sophie H.M. van Dalen, D. D. van den Bos, Martin‐Leo Hansmann, J Medina Feliz, Sara Z. Kuiper, Ziena Abdulrahman, S R Pruijssers, Shebani Farik, Benjamin Elliott, V P Geneta, Michael J. J. Chu, Stephen B. Wilton, H Kandelaki, Shuang Peng, Simon Campbell, Yee-Wei Lim, Shahed Yassaie, Michael J. Murray, Paul Fagan, Cheyaanthan Haran, J Tan, João Pimenta de Castro, Andréia Ferreira Laranjeira, Susana O. Catarino, C Neves-Marques, J. G. Correia, Bárbara Vieira, Catarina Quintela, Marta Serra, J Maciel, Miguel F Cunha, David Aparício, José Farela Neves, José Azevedo, Manuela Romano, F Eiró, Joana Romano, Cristina Monteiro, M Claro, Manuela Almeida, Mariana Peyroteo, N D Machado, Hugo Capote, Margarida Ferreira, Xavier de Sousa, Helena Devesa, Demetrio Cavadas, I Guerreiro, Maria Laura Costa, M Salman, C English, N Mohammed, S S Popescu, A Yanishev, Andrey Litvin, V Cuk, K Mészárosová, Stephanie Van Straten, Robert Jaich, Henrique Lima, Savannah Brooks,
Abstract Background Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary ...
Oxford University Press
Sandra Lasurt, Andrés Combalía-Aleu,
Traumatic hemipelvectomy or hindquarter amputation 2 Cavadas P.C. Landin L. Traumatic complete hemipelvectomy treated with a free fillet flap. J Trauma. 2007; 62: 1-3 Crossref PubMed Scopus ( ... caused by a high kinetic energy force. 2 Cavadas P.C. Landin L. Traumatic complete hemipelvectomy treated ...
Tópico(s): Spinal Fractures and Fixation Techniques
2010 - Elsevier BV | Injury
Pedro C. Cavadas, Luis Landín,
... November 11, 2005. Address for reprints: Pedro C. Cavadas, MD, PhD, Temple 5, 2, 46003 Valencia, Spain; ...
Tópico(s): Sarcoma Diagnosis and Treatment
2007 - Lippincott Williams & Wilkins | Journal of Trauma and Acute Care Surgery
Jens R. Bundgaard, Henrik Birkedal, Jens F. Rehfeld,
... basic residues for sorting (23Brakch N. Allemandou F. Cavadas C. Grouzmann E. Brunner H.R. J. Neurochem. ... Google Scholar), proneuropeptide Y (23Brakch N. Allemandou F. Cavadas C. Grouzmann E. Brunner H.R. J. Neurochem. ...
Tópico(s): Glycosylation and Glycoproteins Research
2004 - Elsevier BV | Journal of Biological Chemistry
Pedro C. Cavadas, Juan R. Sanz-Giménez-Rico, Arturo Gutierrez-de la Cámara, A. Navarro-Monzonis, Santiago Soler-Nomdedeu, Francisco Martı́nez-Soriano,
Cavadas, Pedro C. M.D., Ph.D.; Sanz-Giménez-Rico, Juan R. M.D.; la Cámara, Arturo ...
Tópico(s): Bone fractures and treatments
2001 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery
Palmina Petruzzo, M. Lanzetta, Jean‐Michel Dubernard, R. Margreiter, Frédéric Schuind, Warren Breidenbach, Jerzy Jabłecki, Luis Landín, P.C. Cavadas,
... Schuind, F; Breidenbach, W; Jablecki, J; Landin, L; Cavadas, P Author Information
Tópico(s): Reconstructive Facial Surgery Techniques
2008 - Wolters Kluwer | Transplantation
Luis Landín, Pedro C. Cavadas,
... de Recuperación y Rehabilitación de Levante, Valencia, Spain (Cavadas)
Tópico(s): Facial Nerve Paralysis Treatment and Research
2005 - Lippincott Williams & Wilkins | Annals of Plastic Surgery
... 18, 2001; revised September 24, 2001. Pedro C. Cavadas, M.D., Ph.D. Temple 5, 2 46003 ...
Tópico(s): Reconstructive Facial Surgery Techniques
2003 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery
... 18, 2001; revised September 24, 2001. Pedro C. Cavadas, M.D., Ph.D. Temple 5, 2 46003 ...
Tópico(s): Reconstructive Facial Surgery Techniques
2003 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery
Palmina Petruzzo, M. Lanzetta, J. M. Dubernard, P. Cavadas, R. Margreiter, Frédéric Schuind, Warren C. Breidenbach, J. Jableki, S. Schneeberger, C. Kaufman, L. Landin,
Petruzzo, P.; Lanzetta, M.; Dubernard, J. M.; Cavadas, P.; Margreiter, R.; Schuind, F.; Breidenbach, W.; Jableki, J.; Schneeberger, S.; Kaufman, C.; Landin, L. Author Information
Tópico(s): Reconstructive Facial Surgery Techniques
2010 - Wolters Kluwer | Transplantation
Pedro C. Cavadas, Javier Ibáñez, Luis Landín, Ignacio Roger,
Cavadas, Pedro C. M.D., Ph.D.; Ibañez, Javier M.D.; Landin, Luis M.D.; Roger, Ignacio ...
Tópico(s): Orthopedic Surgery and Rehabilitation
2008 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery
Filipe Cavadas, Ian F. C. Smith, Joaquim Figueiras,
Developed economies depend on complex and extensive systems of infrastructure to maintain economic prosperity and quality of life. In recent years, the implementation of Structural health monitoring (SHM) systems on full-scale bridges has increased. The goal of these systems is to inform owners of the condition of structures, thereby supporting surveillance, maintenance and other management tasks. Data-driven methods, that involve tracking changes in signals only, are well-suited for analyzing measurements ...
Tópico(s): Concrete Corrosion and Durability
2013 - Elsevier BV | Mechanical Systems and Signal Processing
Joana Gaifem, Cláudia S. Rodrigues, Francesca Petralia, Inês Alves, Eduarda Leite-Gomes, Bruno Cavadas, Ana M. Dias, Catarina Moreira-Barbosa, Joana Revés, Renée M. Laird, Mislav Novokmet, Jerko Štambuk, Siniša Habazin, Berk Turhan, Zeynep H. Gümüş, Ryan C. Ungaro, Joana Torres, Gordan Lauc, Jean–Fréderic Colombel, Chad K. Porter, Salomé S. Pinho,
Abstract Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There is growing evidence in Crohn’s disease (CD) of the existence of a preclinical period characterized by immunological changes preceding symptom onset that starts years before diagnosis. Gaining insight into this preclinical phase will allow disease prediction and prevention. Analysis of preclinical serum samples, up to 6 years before IBD diagnosis (from the PREDICTS cohort), revealed the identification ...
Tópico(s): Galectins and Cancer Biology
2024 - Nature Portfolio | Nature Immunology
Vasco Lucas, Cláudia Cavadas, Célia A. Aveleira,
An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, several studies have provided evidence of the prominent role of cellular senescence in many of these pathologies. Key traits of senescent cells include cell cycle arrest, apoptosis resistance, and secretome shift to senescence-associated secretory phenotype resulting in increased secretion of various intermediate bioactive factors important for senescence pathophysiology. ...
Tópico(s): Circadian rhythm and melatonin
2023 - American Society for Pharmacology and Experimental Therapeutics | Pharmacological Reviews
Catarina Carvalhas-Almeida, Joana Serra, J. Moita, Cláudia Cavadas, Ana Rita Álvaro,
According to the World Health Organization, about one-third of the population experiences insomnia symptoms, and about 10-15% suffer from chronic insomnia, the most common sleep disorder. Sleeping difficulties associated with insomnia are often linked to chronic sleep deprivation, which has a negative health impact partly due to disruption in the internal synchronisation of biological clocks. These are regulated by clock genes and modulate most biological processes. Most studies addressing circadian ...
Tópico(s): Sleep and related disorders
2023 - Elsevier BV | Neuroscience & Biobehavioral Reviews
Produção Nacional
Revisado por pares
Juliana Poças, Catarina Marques, Catarina Gomes, Andréia Hanada Otake, Filipe Pinto, Mariana Ferreira, Tiago Silva, Isabel Faria‐Ramos, Rita Matos, Ana Raquel Ribeiro, Emanuel Senra, Bruno Cavadas, Sílvia Batista, Joana Maia, Joana A. Macedo, Luís Lima, Luís Pedro Afonso, José Alexandre Ferreira, Lúcio Lara Santos, António Polónia, Hugo Osório, Mattias Belting, Celso A. Reis, Bruno Costa‐Silva, Ana Magalhães,
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane proteoglycan, is highly expressed in intestinal subtype gastric tumors and that this signature associates with patient poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer cell motility and invasion. We also find that SDC4 decorated with heparan sulfate is efficiently sorted in extracellular ...
Tópico(s): Cell Adhesion Molecules Research
2023 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Catarina Carvalhas-Almeida, Cláudia Cavadas, Ana Rita Álvaro,
Throughout the course of life, there are age-related changes in sleep. Despite these normal changes, there is a high percentage of older adults that report sleep dissatisfaction with a high pervasiveness of chronic insomnia, the most common sleep disorder worldwide, with its prevalence being expected to continuously increase due to the growing rates of aging and obesity. This can have different adverse health outcomes, especially by promoting both physical and cognitive decline, which ultimately ...
Tópico(s): Circadian rhythm and melatonin
2022 - Springer Science+Business Media | Aging Clinical and Experimental Research
Laetitia S. Gaspar, Ana Santos-Carvalho, Bárbara Santos, Catarina Carvalhas-Almeida, Ana Teresa Barros-Viegas, Bárbara Oliveiros, Helena Donato, Clara Faria Souza Mendes dos Santos, J. Moita, Cláudia Cavadas, Ana Rita Álvaro,
Obstructive Sleep Apnea (OSA) has been recognized as a major health concern worldwide, given its increasing prevalence, difficulties in diagnosis and treatment, and impact on health, economy, and society. Clinical guidelines highlight the need of biomarkers to guide OSA clinical decision-making, but so far, without success. In this systematic review and meta-analysis, registered on the International Prospective Register of Systematic Reviews database (ID CRD42020132556), we proposed to gather and ...
Tópico(s): Neuroscience of respiration and sleep
2022 - Elsevier BV | Sleep Medicine Reviews
Carolina F. Ruivo, Nuno Bastos, Bárbara Adem, Inês A. Batista, Cecília Durães, Carlos A. Melo, Stéphanie A. Castaldo, Francisco Campos‐Laborie, Pedro Moutinho-Ribeiro, B Morão, Ana Rita Costa-Pinto, Soraia Silva, Hugo Osório, Sergio Ciordia, José Luís Costa, David W. Goodrich, Bruno Cavadas, Luı́sa Pereira, Tony Kouzarides, Guilherme Macedo, Rui Maio, Fátima Carneiro, Marília Cravo, Raghu Kalluri, José Carlos Machado, Sónia A. Melo,
Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour.
Tópico(s): Hippo pathway signaling and YAP/TAZ
2022 - BMJ | Gut
Ana Catarina Franco, Célia A. Aveleira, Cláudia Cavadas,
With age, senescent cells accumulate in the skin and spread the aging phenotype to neighboring cells, resulting in decreased thickness, regenerative capacity, and a barrier effect in the skin. Aging and cellular senescence phenotypes in the skin were found to correlate with immunosenescence, longevity, or cardiovascular disease risk. Skin aging, induced by ultraviolet radiation, has an impact in the brain, by decreasing hippocampal neurogenesis and activating the central hypothalamic–pituitary–adrenal ...
Tópico(s): Circadian rhythm and melatonin
2022 - Elsevier BV | Trends in Molecular Medicine