Chul Bom Lee, Ting‐Chao Chou, Xiuguo Zhang, Zhiguang Wang, Scott D. Kuduk, Mark D. Chappell, Shawn J. Stachel, Samuel J. Danishefsky,
A new epothilone analogue, 12,13-desoxyepothilone F (dEpoF, 21-hydroxy-12,13-desoxyepothilone B, 21-hydroxyepothilone D), was synthesized and evaluated for antitumor potential. A convergent strategy employed for the semipractical synthesis of 12,13-desoxyepothilone B (dEpoB) has been utilized to yield an amount of dEpoF sufficient for relevant biological studies. The results from an in vitro assay reveal that this new analogue is highly active against various tumor cell lines with a potency comparable ...
Tópico(s): Histone Deacetylase Inhibitors Research
2000 - American Chemical Society | The Journal of Organic Chemistry
Toi J. Tsilo, Şenay Şimşek, Jae‐Bom Ohm, Gary A. Hareland, Shiaoman Chao, James A. Anderson,
Wheat end product quality is determined by a complex group of traits including dough viscoelastic characteristics and bread-making properties. Quantitative trait loci (QTL) mapping and analysis were conducted for endosperm texture, dough-mixing strength, and bread-making properties in a population of 139 (MN99394 × MN98550) recombinant inbred lines that were evaluated at three environments in 2006. Based on the genetic map of 534 loci, six QTL were identified for endosperm texture, with the main QTL ...
Tópico(s): Food composition and properties
2011 - NRC Research Press | Genome
Shawn J. Stachel, Mark D. Chappell, Chul Bom Lee, Samuel J. Danishefsky, Ting‐Chao Chou, Lifeng He, Susan Band Horwitz,
The syntheses of two epothilone analogues, 15(S)-aza-12,13-desoxyepothilone B and the epimeric 15(R)-aza-12,13-desoxyepothilone B, are described. A Mitsunobu inversion was utilized for elaboration of pre-epothilone fragments to the corresponding macrolactam. Tubulin binding and cytotoxicity profiles of these analogues are presented.
Tópico(s): Synthetic Organic Chemistry Methods
2000 - American Chemical Society | Organic Letters
With the proliferation of IoT devices, the distributed control systems are now capturing and processing more sensors at higher frequency than ever before. These new data, due to their volume and novelty, cannot be effectively consumed without the help of data-driven techniques. Deep learning is emerging as a promising technique to analyze these data, particularly in soft sensor modeling. The strong representational capabilities on complex data and the flexibility it offers from an architectural ...
Tópico(s): Machine Learning and ELM
2021 - Springer Science+Business Media | Communications in computer and information science
Hubert Josien, David Bom, Dennis P. Curran, Yu‐Huang Zheng, Ting‐Chao Chou,
The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays.
Tópico(s): Synthetic Organic Chemistry Methods
1997 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Kristin Simons, James A. Anderson, Mohamed Mergoum, Justin D. Faris, Daryl L. Klindworth, Steven S. Xu, Clay Sneller, Jae‐Bom Ohm, Gary A. Hareland, Michael C. Edwards, Shiaoman Chao,
ABSTRACT In this study we assess the genetic architecture of bread‐making quality traits in spring wheat ( Triticum aestivum L.). A mapping population derived from BR34 and ‘Grandin’ was used to measure 20 end‐use quality traits including six kernel, seven milling and flour, four dough mixing strength, and three bread‐making traits. A total of 31 quantitative trait loci (QTL) significantly associated with all but two traits were identified. These QTL were clustered in five chromosomal regions, namely ...
Tópico(s): Genetics and Plant Breeding
2012 - Wiley | Crop Science
Mark D. Chappell, Christina R. Harris, Scott D. Kuduk, Aaron Balog, Zhicai Wu, Fei Zhang, Chul Bom Lee, Shawn J. Stachel, Samuel J. Danishefsky, Ting‐Chao Chou, Yongbiao Guan,
A practical total synthesis of 26-(1,3-dioxolanyl)-12,13-desoxyepothilone B (26-dioxolanyl dEpoB) was accomplished in a highly convergent manner. A novel sequence was developed to produce the vinyl iodide segment 17 in high enantiomeric excess, which was used in a key B-alkyl Suzuki merger. Subsequently, a Yamaguchi macrocyclization formed the core lactone, while a selective oxidation and a late stage Noyori acetalization incorporated the dioxolane functionality. Sufficient amounts of synthetic 26- ...
Tópico(s): Advanced Synthetic Organic Chemistry
2002 - American Chemical Society | The Journal of Organic Chemistry
Daiane Borges Queiroz, Claudinéia Matos de Araújo, Marta Moreira Novais, Lorena Cajaíba de Oliveira, Luciara Araujo Andrade, Luciana Araújo dos Reis,
... médio na ativi-dade de equilíbrio (42,9%), bom nas atividades de sentar/levantar (82,5%), agachar/pegar um lápis no chão (87,3%) e caminhada (96,8%). Não foi ...
Tópico(s): Academic Research in Diverse Fields
2016 - FACULDADE DE MEDICINA DE SÃO JOSÉ DO RIO PRETO | Arquivos de Ciências da Saúde
Chul Bom Lee, Zhicai Wu, Fei Zhang, Mark D. Chappell, Shawn J. Stachel, Ting‐Chao Chou, Yongbiao Guan, Samuel J. Danishefsky,
A processable total synthesis of a potent antitumor agent, desoxyepothilone F (dEpoF, 21-hydroxy-12,13-desoxyepothilone B, 21-hydroxyepothilone D), has been accomplished. The route is highly convergent. The new technology has also been applied to a total synthesis of 12,13-desoxyepothilone (dEpoB). The crucial point of departure from previous syntheses of dEpoB and dEpoF involves presentation of the C1−C11 sector for Suzuki coupling with C3 in reduced form. Hitherto, the required S stereochemistry ...
Tópico(s): Advanced Synthetic Organic Chemistry
2001 - American Chemical Society | Journal of the American Chemical Society
Shawn J. Stachel, Chul Bom Lee, Maria Spassova, Mark D. Chappell, William G. Bornmann, Samuel J. Danishefsky, Ting‐Chao Chou, Yongbiao Guan,
The total syntheses of 12,13,15-desoxy-15(S)-aza-epothilone B (aza-dEpoB; dEpoB-lactam) and 12,13,15-desoxy-15(R)-aza-epothilone B (15-epi-aza-dEpoB; 15-epi-dEpoB-lactam) have been accomplished via a highly convergent strategy. We have also successfully oxidized 12,13,15-desoxy-15(S)-aza-epothilone B to aza-epothilone B (aza-EpoB; EpoB-lactam). Aza-epothilone B has been advanced to phase I clinical trials by the Bristol-Myers Squibb group. Our synthesis is efficient and was amenable to the production ...
Tópico(s): Advanced Synthetic Organic Chemistry
2001 - American Chemical Society | The Journal of Organic Chemistry
Zhixia Niu, Daryl L. Klindworth, Guotai Yu, Timothy L. Friesen, Shiaoman Chao, Jin Ye, Xiwen Cai, Jae‐Bom Ohm, J. B. Rasmussen, Steven S. Xu,
Tópico(s): Genetics and Plant Breeding
2014 - Springer Science+Business Media | Theoretical and Applied Genetics
Maneka Malalgoda, Jae‐Bom Ohm, Steven W. Meinhardt, Shiaoman Chao, Şenay Şimşek,
Thirty hard red spring (HRS) wheat cultivars released between 1910 and 2013 were analyzed to determine how they cluster in terms of parentage and HPLC analysis of gliadins and unreduced proteins. Markers for reduced height genes were assessed to determine associations between semidwarfism and protein composition, as well as quality characteristics. In terms of parentage, the clusters formed were grouped according to release year and semidwarfism. Farinograph development time and stability showed ...
Tópico(s): Genetics and Plant Breeding
2017 - Wiley | Cereal Chemistry
Zhi Chen, Ren Chao, Miyuan Shan,
JMI is an advanced inventory management method, how to implement JMI to reduce overall supply chain inventory cost and how to undertake profit allocation is a hot topic in the study of inventory management. But the current study rarely considering BOM, much less BOM's impact on supply chain inventory cost under the multi-product environment. This paper studies the two level supply chain including single manufacturer and multi-supplier of multi-product, and analyzes the BOM of multi-product, then ...
Tópico(s): Quality and Supply Management
2014 - IGI Global | International Journal of Advanced Pervasive and Ubiquitous Computing
Toi J. Tsilo, Jae‐Bom Ohm, Gary A. Hareland, Shiaoman Chao, James A. Anderson,
Wheat bread-making quality is influenced by a complex group of traits including dough visco-elastic characteristics. In this study, quantitative trait locus/loci (QTL) mapping and analysis were conducted for endosperm polymeric proteins together with dough mixing strength and bread-making properties in a population of 139 (MN98550 × MN99394) recombinant inbred lines that was evaluated at three environments in 2006. Eleven chromosome regions were associated with endosperm polymeric proteins, explaining ...
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2011 - Czech Academy of Agricultural Sciences | Czech Journal of Genetics and Plant Breeding
Produção Nacional
Revisado por pares
Marta Moreira Novais, Claudinéia Matos de Araújo, Sara Vilas Bôas, Rahab Vieira Prates, Daniela Daniela de Souza Pinto, Luciana Araújo dos Reis,
... encontrado desempenho médio para equilíbrio (48,7%) e bom para sentar/levantar (88,9%), agachar/pegar lápis no chão (94,9%) e caminhada (99,1%). Conclusão: Com ...
Tópico(s): Healthcare Regulation
2016 - FACULDADE DE MEDICINA DE SÃO JOSÉ DO RIO PRETO | Arquivos de Ciências da Saúde
Claudino Luís Tavares Monteiro, Adelino Lopes da Silva,
... função quadrática”, foi implementado na Escola Secundária de Chão Bom, com uma turma do 10º ano. A proposta ...
Tópico(s): Diverse scientific research topics
2023 - PONTIFÍCIA UNIVERSIDADE CATÓLICA DE SÃO PAULO | Revista do Instituto GeoGebra Internacional de São Paulo
... foram feitos prisioneiros ou morreram no Campo de Chão Bom, no Tarrafal, em Cabo Verde, campo que abrigou ...
Tópico(s): African history and culture studies
2012 - Associação Brasileira de História Oral (ABHO) | História Oral
Sara Todo Bom Costa, Lurdes Sampaio, Ana Berta Sousa, Chao Xing, Anil K. Agarwal, Abhimanyu Garg,
Congenital generalized lipodystrophy, type 1 (CGL1), due to biallelic pathogenic variants in AGPAT2, is characterized by the near total loss of body fat from the face, trunk, and extremities. Patients develop premature diabetes, hypertriglyceridemia, hepatic steatosis, and polycystic ovary syndrome. However, sparing of the facial fat and precocious pubertal development has not been previously reported in CGL1.We report a 21-year-old woman of European descent with CGL1 who had sparing of the facial ...
Tópico(s): Diabetes and associated disorders
2022 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Produção Nacional
Andrea Santos Baca, Gloria Idalia Baca Lobera,
O artigo desenvolve uma análise critica de um dos aspetos da crise alimentar atual: o problema no redor da determinação de que é bom para comer. Condição que tem levado ao desvanecimento da linha que contrapunha o problema da fome ao problema da obesidade, concentrando ambas no conceito de má nutrição. O artigo emprega os conceitos de fetichismo da mercadoria e a lógica do lucro para demonstrar, primeiro que a chamada cacofonia alimentar é o produto da mediação mercantil da alimentação. E segundo ...
Tópico(s): Social and Economic Solidarity
2018 - Editora da Geografia | Geografares
Chul Bom Lee, Ting‐Chao Chou, Xiu‐Guo Zhang, Zhiguang Wang, Scott D. Kuduk, Mark D. Chappell, Shawn J. Stachel, Samuel J. Danishefsky,
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tópico(s): Marine Sponges and Natural Products
2001 - Wiley | ChemInform
Produção Nacional
Marco Antônio Guimarães Da Silva,
... Há um vilarejo ali Onde areja um vento bom Na varanda, quem descansa Vê o horizonte deitar no chão Pra acalmar o coração Lá o mundo tem ...
Tópico(s): Brazilian cultural history and politics
2018 - Convergences Editorial | Fisioterapia Brasil
ABSTRACT "Organized chaos" is the theme of the short history of the Internet and social work. It is a history of paradoxes. Although there are many paths to follow the historical influence of the Internet for social work, this essay notes that the Internet was bom from a military strategy. Decades later, social work education and practice employed this massive network. This essay traces ...
Tópico(s): Social Work Education and Practice
1997 - Taylor & Francis | Computers in Human Services
Paul G. Yock, David T. Linker,
... LANGENHOVE G, LUPOTTI F, ALBERTAL M, MASTIK F, BOM K and SERRUYS P (1999) Coronary Flow Reserve ... 1999.849311, 0-7803-5722-1, (1645-1648) Bom N, Li W, Carlier S, Céspedes I and ... 1995.495784, 0-7803-2940-6, (1251-1254) Bom N, Li W, van der Steen A, de ... P, van den Brand M, Serruys P and Bom N (1993) Intravascular ultrasound: instrumentation, image interpretation, promises ... L, Smits P, Post M, Gussenhoven W and Bom N (1991) Imaging of post-mortem coronary arteries ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
1990 - Lippincott Williams & Wilkins | Circulation
Tópico(s): ERP Systems Implementation and Impact
2012 - Springer Science+Business Media | Lecture notes in electrical engineering
Feiyang Ou, Julius Suherman, Chao Zhang, Henrik Wang, Sthitie Bom, J. F. Davis, Panagiotis D. Christofides,
Tópico(s): Mineral Processing and Grinding
2025 - Elsevier BV | Digital Chemical Engineering
Feiyang Ou, Henrik Wang, Chao Zhang, Matthew Tom, Sthitie Bom, J. F. Davis, Panagiotis D. Christofides,
Tópico(s): Advanced Control Systems Optimization
2024 - Elsevier BV | Digital Chemical Engineering
Mengxia Zhang, Ting Liu, Rui You, Xiong Zou, Yong‐Long Liu, Xi Ding, Chongyang Duan, Hanshi Xu, You‐Ping Liu, Rou Jiang, Zhiqiang Wang, Chao Lin, Yu‐Long Xie, Siyuan Chen, Yan‐Feng Ouyang, Ruo-Qi Xie, Yi‐Jun Hua, Rui Sun, Pei‐Yu Huang, Shunlan Wang, Ming‐Yuan Chen,
... 0.007, respectively) but not of bone metastasis (BoM; p = 0.614). Radiotherapy was predominantly used for BoM and biological effective dose (BED) >60 Gy was ...
Tópico(s): Head and Neck Cancer Studies
2022 - SAGE Publishing | Therapeutic Advances in Medical Oncology
Shawn J. Stachel, Mark D. Chappell, Chul Bom Lee, Samuel J. Danishefsky, Ting‐Chao Chou, Lifeng He, Susan Band Horwitz,
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tópico(s): Advanced Synthetic Organic Chemistry
2000 - Wiley | ChemInform
Produção Nacional
... um saber criminologico critico e os pes no chao, no sistema prisional, podem constituir em um bom caminho para a inducao de politicas publicas no ...
Tópico(s): Public Health in Brazil
2019 - | Direito Público
Produção Nacional
Sabrina Coutro Miranda, Manoel Cláudio da Silva Júnior, Leandro Almeida Salles,
... arenito e quartzito. Este é ainda encontrado em bom estado de conservação principalmente devido ao acesso relativamente ... nats.ind-1, equalibilidade Jââ?¬â?¢=0,79, Chao 1= 66 e Chao 2 = 63 espécies refletem a alta diversidade florí ...
Tópico(s): Amazonian Archaeology and Ethnohistory
2015 - | Heringeriana