Phil Yates, Jon Ashworth, Hooper, David Tytler, DJM, Anatol Lieven, Barry Trowbridge, Jeremy Laurance, Simon Barnes, Anatole Kaletsky and Sheila Gunn, Tim Judah, Sheila Gunn, Political Correspondent, Andrew Strong, Michael Stevenson, John Osborne, Michael Binyon, Jeremy Kingston, Wolfgang Münchau, European Business Correspondent, Richard Eaton, Kevin Eason, Motoring Correspondent, Stuart Jones Football Correspondent, Colin Narbrough, Melinda Wittstock and Colin Campbell, Geoff Brown, Gerald Davies, Philip Bassett Industrial Editor, Joe Joseph, Bernard Levin, Bryan Stiles, Ruth Gledhill, Religion Correspondent, Peter Ball, Chris Lowe, Louise Taylor, Roger James, Martin Barrow, Peter Bills, Michael Evans, Defence Correspondent, Ray Kennedy, Nicholas Watt, John O'Leary, Philip Robinson, Reuter, Charles Bremner, John O'leary, Peter Barnard, Philip Bassett, Industrial Editor, J. A. Brennan, Jose Guerreiro Alves Primo, Tim Judah and Anne McElvoy, John Hennessy, Robert Cockburn, Russell Kempson, Michael McCarthy Environment Correspondent, Sydney Friskin, Melinda Wittstock Media Correspondent, David Miller, Gillian Bowditch, Judi Bevan, John Higgins, Kerry Gill, Alan Lee, Cricket Correspondent, Raymond Keene, Chess Correspondent, Peter Stothard, Paul Griffiths, Peter Bryan, Dick Hinder, Racing Editor, Richard Evans, David Powell, Athletics Correspondent, Damian Whitworth, Mary Dejevsky and Robert Seely, Roger Boyes, Frederick Lawton, Ian Ross, David Aberbach, Keith MacKlin, David Hands Rugby Correspondent, Nicholas Woolley, Arthur Goldstuck, Christopher Thomas, Eric Birley, Joanna Pitman, David Young, Patrick Moser, Ross Tieman Industrial Correspondent, Edward Gorman, Ireland Correspondent, Nick Nuttall, Technology Correspondent, Christopher Walker, James Pringle, Alfred Hermida, Colin Narbrough, Economics Correspondent, Clive White, Michael Seely, Keith Blackmore, Bryan Askew, Peter Riddell, Lindsay Jamieson, David Holloway, Tony Dawe, Richard Beeston, Michael Phillips, Penny Rose, David Sinclair, Simon Wright, Philip Pangalos, Benedict Nightingale, T. R. Miles, Frances Gibb, Andrew Crowther, Andrew Finkel, John Phillips, Colin Campbell, David Hands, Rugby Correspondent, Andrew Longmore, Tennis Correspondent, Mary Dejevsky, Michael Hornsby Agriculture Correspondent,
Algeria election called off after president quits Tanks and troops patrol streets The Times is Giving Away Money Glum Strum Tide Pride Index Virgin puts ...
1992 - Gale Group | TDA
Pierre Chassagne, Carolina Fontana, Catherine Guerreiro, Charles Gauthier, Armelle Phalipon, Göran Widmalm, Laurence A. Mulard,
Abstract Extensive analysis by NMR spectroscopy of the delipidated lipopolysaccharide of Shigella flexneri serotype 6 strain MDC 2924‐71 confirmed the most recently reported structure of the O‐antigen repeating unit as {→4)‐β‐ D ‐Gal p A‐(1→3)‐β‐ D ‐Gal p NAc‐(1→2)‐α‐ L ‐Rha p 3Ac/4Ac ‐(1→2)‐α‐ L ‐Rha p ‐(1→}, and revealed the non‐stoichiometric acetylation at O‐3 C /4 C . Input from the CASPER program helped to ascertain the fine distribution of the three possible patterns of O ‐acetylation. The non‐ O ‐acetylated ...
Tópico(s): Escherichia coli research studies
2013 - Wiley | European Journal of Organic Chemistry
RADICAL., WILLIAM DEEDES, KENDALENSIS., J. G., A GOWNSMAN., CAUTION., CHARLES CARUS WILSON., AN INVALID., [From a Correspondent.], L., ORPHEUS., X. L. X., FIDES., E. CLARKSON, OBSERVER, X., RICHARD SPARLING HADWEN,
... Imperial Majesty The Duke Of Braganza, To Senhor Guerreiro, One Of The Members Of The Regency Of ...
1831 - Gale Group | TDA
Srikanth Reddy, Shantanu Bhattacharjya, Nikolai Maniakin, Joanne Greenwood, D. Guerreiro, David Hughes, Charles Imber, David Pigott, Susan V. Fuggle, R. P. Taylor, Peter J. Friend,
Background. Normothermic perfusion has been shown to resuscitate and maintain viability of non–heart-beating donor (NHBD) livers that have undergone significant warm ischemic injury. However, the logistics of clinical organ retrieval are complex, and a period of cold storage before warm preservation would simplify the process. We have investigated the effects of short duration of cold preservation before normothermic preservation on the function of porcine NHBD livers. Methods. Porcine livers were ...
Tópico(s): Liver Disease Diagnosis and Treatment
2004 - Wolters Kluwer | Transplantation
By Philip Webster, Political Reporter, By Nicholas Timmins, By Anthony Bevins, Political Correspondent, From Mario Modiano Athens, By Frances Williams, Economics Correspondent, By Barrie Clement, Labour Reporter, From Christopher Walker Khalde, From Richard Ford, Belfast, By Baron Phillips, Property Correspondent, By Rodney Cowton, Defence Correspondent, By Barrie Clement Labour Party, By Lucy Hodges Education Correspondent, By Rupert Morris, By Geraldine Norman Sale Room Correspondent, By Frances Gibb, Legal Affairs Correspondent, By Hugh Clayton, Environment Correspondent, By the Staff of Nature., By John Witherow, By David Nicholson-Lord, By Peter Evans, Home Affairs Correspondent, By a Staff Reporter, From Our Correspondent Birmingham, By Kenneth Gosling, From Our Correspondent, Leeds, By Paul Routledge, Labour Editor, By Our Political Staff, Ronald Faux, By David Hewson, Craig Seton, By Ian Bradley, By Julian Haviland Political Editor, From David Felton, By Our Political Editor, By Barbara Day, From Nicholas Ashford, Washington, From Alan McGregor, Geneva, From Frederick Bonnart Brussels, By Richard Dowden, From Andrew Thompson, Buenos Aires, From Diana Geddes, Paris, From Michael Binvon, From Ian Murray, From Roger Boyes Warsaw, From Richard Wigg, Madrid, From Harry Debelius, Madrid, From Our Correspondent, Colombo, From Tony Duboudin, From Charles Harrison, Nairobi, From Robert Fisk, Damascus, From Michael Hornsby, Johannesburg, From Our Own Correspondent, Washington, Irving Wardle, David Robinson, John Percival, Max Harrison, Peter Ackroyd, Diana Davenport, Diana Marchington, PHS, Colin Harding, Paul Pickering, Jock Bruce-Gardyne, James Curran, BEN VINCENT., MATTHEW M. GUERREIRO, , MICHAEL GRAHAM-JONES, D. C. SPENCER., STUART WALKER, , MICHAEL J. de C. STUDDERT., ERIC JAMES., SEAN MCGRAIL, , C. VELJANOVSKI, , BERNARD BRADEN, , MARTIN HOLMES., JOHN WARD, General Secretary, , MARY LOCHNER., B. CLARK., TOM WILLIAMSON., By Robert Nowell, From Our Correspondent Seoul, City Editor Anthony Hilton, From Maxwell Newton, By Michael Prest, By Derek Harris, Commercial Editor, By Our Financial Staff, By Jeremy Warner, By Jonathan Davis, By David Young, By Michael Clark, By Jonathan Clare, By Victor Felstead, edited by Sandy McLachlan, Edward Townsend, by Michael Clark, By Peter Ball, By Alan Gibson, By John Woodcock, Cricket Correspondent, By Gerald Richmond, By Richard Streeton, DAVID MILLER, By Lewine Mair, By Stuart Jones, Football Correspondent, By Stuart Jones, By Peter Walker, Simon Barnes, By Srikumar Sen, Boxing Correspondent, By Keith Macklin, By Sydney Friskin, By John Nicholls, By Michael Phillips, Racing Correspondent, By John Karter, By Desmond Stoneham, French Racing Correspondent, By Ian Reid, Baron Phillips, Edited by Peter Dear, PH, By Geraldine Norman, Sale Room Correspondent,
News: New threat by water workers, Moscow accepts Reagan offer on grain sales, Peace hope in Timex dispute, Float along with me MOREOVER... Miles Kington, ...
1983 - Gale Group | TDA
Produção Nacional
Revisado por pares
Ana Flávia P. Rodrigues, Igor M. Guerreiro, Charles C. Cavalcante,
In this paper, we present a method for portfolio selection based on the consideration on deformed exponentials in order to generalize the methods based on the gaussianity of the returns in portfolio, such as the Markowitz model. The proposed method generalizes the idea of optimizing mean-variance and mean-divergence models and allows a more accurate behavior for situations where heavy-tails distributions are necessary to describe the returns in a given time instant, such as those observed in economic ...
Tópico(s): Statistical and numerical algorithms
2018 - World Scientific | International Journal of Modern Physics C
Katja Matheis, Emmanuelle Com, Jean‐Charles Gautier, Nelson Guerreiro, Arnd Brandenburg, Hans Gmuender, Alexandra Sposny, Philip Hewitt, Alexander Amberg, K. Olaf Boernsen, Bjoern Riefke, Dana Hoffmann, Angela Mally, Arno Kalkuhl, Laura Suter‐Dick, Frank Dieterle, Frank Staedtler,
The European InnoMed–PredTox project was a collaborative effort between 15 pharmaceutical companies, 2 small and mid-sized enterprises, and 3 universities with the goal of delivering deeper insights into the molecular mechanisms of kidney and liver toxicity and to identify mechanism-linked diagnostic or prognostic safety biomarker candidates by combining conventional toxicological parameters with “omics” data. Mechanistic toxicity studies with 16 different compounds, 2 dose levels, and 3 time points ...
Tópico(s): Acute Kidney Injury Research
2010 - Elsevier BV | Toxicology and Applied Pharmacology
Produção Nacional
Revisado por pares
C. Quintero Noda, R. Schlichenmaier, L. R. Bellot Rubio, M. G. Löfdahl, E. Khomenko, J. Jurčák, J. Leenaarts, C. Kuckein, S. J. González Manrique, S. Gunár, C. J. Nelson, J. de la Cruz Rodríguez, K. Tziotziou, G. Tsiropoula, G. Aulanier, Jean Aboudarham, Daniele Allegri, Ernest Alsina Ballester, J.-P. Amans, A. Asensio Ramos, F. J. Bailén, María Balaguer, Veronica Baldini, H. Balthasar, Teresa Barata, Krzysztof Barczyński, M. Barreto, Audrey Baur, Clémentine Béchet, C. Beck, Marta Belío-Asin, N. Bello-González, Luca Belluzzi, R. D. Bentley, S. V. Berdyugina, D. Berghmans, A. Berlicki, F. Berrilli, Thomas Berkefeld, Felix Bettonvil, M. Bianda, J. Bienes Pérez, Sergio Bonaque‐González, R. Brajša, V. Bommier, Philippe-A. Bourdin, J. Burgos Martín, D. Calchetti, Ariadna Calcines, J. Calvo Tovar, R. J. Campbell, Y. Carballo-Martín, V. Carbone, E. S. Carlín, M. Carlsson, J. Castro López, L. Cavaller, F. Cavallini, G. Cauzzi, M. Cecconi, Haresh Chulani, R. Cirami, Giuseppe Consolini, Igor Coretti, R. Cosentino, Juan Cózar-Castellano, K. Dalmasse, S. Danilović, M. de Juan Ovelar, D. Del Moro, Tanausú del Pino Alemán, J. C. del Toro Iniesta, C. Denker, Sajal Kumar Dhara, P. Di Marcantonio, C. J. Díaz Baso, A. Diercke, Ekaterina Dineva, J. J. Díaz, H.‐P. Doerr, Gerry Doyle, R. Erdélyi, I. Ermolli, A. Escobar Rodríguez, S. Esteban Pozuelo, M. Faurobert, T. Felipe, A. Feller, N. Feijoo Amoedo, Bruno Femenía Castellá, J. Fernandes, Irene M. Ferro Rodríguez, I. Figueroa, L. Fletcher, A. Franco Ordovas, R. Gafeira, R.A. Gardenghi, B. Gelly, F. Giorgi, D. Gisler, Luca Giovannelli, Francisco González, J. Becerra González, José M. González-Cava, M. González García, P. Gömöry, Félix Gracia, B. Grauf, Vincenzo Greco, Charles Grivel, Nuno Guerreiro, S. L. Guglielmino, Robert H. Hammerschlag, A. Hanslmeier, V. H. Hansteen, P. Heinzel, A. Hernández-Delgado, Elvio Hernández Suárez, S. L. Hidalgo, F. Hill, J. Hizberger, Stefan J. Hofmeister, Arne S. Jegers, Gioele Janett, Robert Jarolim, D. B. Jess, David Jiménez Mejías, Laurent Jolissaint, R. Kamlah, Josef Kapitán, J. Kašparová, Christoph U. Keller, T. Kentischer, D. Kiselman, Lucia Kleint, M. Klvaňa, I. Kontogiannis, K. Nagaraju, A. Kučera, N. Labrosse, A. Lagg, E. Landi Degl’Innocenti, M. Langlois, Martine Lafon, D. Laforgue, C. Le Men, Benedetto Lepori, Fabio Lepreti, Börje Lindberg, P. B. Lilje, A. López Ariste, V. A. López Fernández, A. C. López Jiménez, Roberto López López, R. Manso Sainz, Alessandro Marassi, José Marco de la Rosa, José Bernardo Mariño Acebal, J. Marrero, A. Martín, A. Martín Gálvez, Yolanda Martín Hernando, Elena Masciadri, M. J. Martínez González, Antonio Matta-Gómez, Ángel Mato, M. Mathioudakis, S. A. Matthews, P. Mein, F. Merlos García, J. Moity, I. Montilla, M. Molinaro, G. Molodij, Luzma Montoya, Matteo Munari, M. Murabito, Miguel Núñez Cagigal, M. Oliviero, D. Orozco Suárez, A. Ortiz, Cristina Padilla-Hernández, E. Paéz Mañá, F. Paletou, J. Pancorbo, A. Pastor Cañedo, A. Pastor Yabar, Aaron W. Peat, Fernando Pedichini, N. Peixinho, José Peñate, A. P. de Taoro, Hardi Peter, K. Petrovay, Roberto Piazzesi, E. Pietropaolo, O. Pleier, Stefaan Poedts, W. Pötzi, Tatiana Podladchikova, Gonzalo Rodríguez Prieto, Jorge Quintero Nehrkorn, R. Ramelli, Y. Ramos Sapena, J. L. Rasilla, K. Reardon, R. Rébolo, Silvia Regalado Olivares, Marcos Reyes García-Talavera, T. L. Riethmüller, Thomas Rimmelé, Horacio Rodríguez Delgado, Nieves Rodríguez González, J. A. Rodríguez-Losada, Luis Fernando Rodríguez-Ramos, P. Romano, M. Roth, L. Rouppe van der Voort, P. Rudawy, Claudia Ruiz de Galarreta, J. Rybák, Andrea Salvadè, Jorge Sánchez-Capuchino, M.L. Sánchez, M. Sangiorgi, Frédéric Sayède, G. B. Scharmer, T. Scheiffelen, W. Schmidt, B. Schmieder, C. Scirè, S. Scuderi, B. Siegel, M. Sigwarth, Paulo J. A. Simões, Frans Snik, Guus Sliepen, M. Sobotka, H. Socas‐Navarro, Paula Sola La Serna, S. K. Solanki, M. Soler Trujillo, D. Soltau, Andrea Sordini, A. Sosa Méndez, M. Stangalini, O. Steiner, J. O. Stenflo, Jiří Štěpán, K. G. Strassmeier, D. Sudar, Y. Suematsu, P. Sütterlin, Michel Tallon, Manuela Temmer, F. Tenegi, A. Tritschler, J. Trujillo Bueno, Alessio Turchi, D. Utz, Gerard van Harten, M. van Noort, Tim van Werkhoven, R. Vansintjan, J. J. Vaz Cedillo, Nauzet Vega Reyes, M. Verma, Astrid Veronig, Giorgio Viavattene, N. Vitas, A. Vögler, O. von der Lühe, R. Volkmer, T. Waldmann, David M. Walton, A. Wiśniewska, J. Zeman, Franziska Zeuner, L. Q. Zhang, F. Zuccarello, M. Collados,
The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope (SST), the German Vacuum Tower Telescope (VTT) and GREGOR, the French T\'elescope ...
EDP Sciences | Astronomy and Astrophysics
Produção Nacional
Revisado por pares
Igor M. Guerreiro, Dennis Hui, Charles C. Cavalcante,
This paper addresses distributed parameter coordination methods for wireless communication systems. This proposes a method based on a message-passing algorithm, namely min-sum algorithm, on factor graphs for the application of precoder selection. Two particular examples of precoder selection are considered: transmit antenna selection and beam selection. Evaluations on the potential of such an approach in a wireless communication network are provided, and its performance and convergence properties ...
Tópico(s): Advanced MIMO Systems Optimization
2013 - Springer Science+Business Media | EURASIP Journal on Advances in Signal Processing
Charles R. Marshall, Rita Guerreiro, Stefanie Thust, Phillip D. Fletcher, Jonathan D. Rohrer, Nick C. Fox,
The authors describe a case of corticobasal syndrome led by progressive apraxia of speech, associated with a novel mutation in exon 10 of the MAPT gene. Genetic bases for progressive apraxia of speech and corticobasal syndrome are only rarely described, and have not been described in conjunction.
Tópico(s): Genetic Neurodegenerative Diseases
2015 - IOS Press | Journal of Alzheimer s Disease
Produção Nacional
Jonathas Teixeira Lisboa, Erminda da Conceição Guerreiro Couto, Pollyanna Pereira Santos, Jacques Hubert Charles Delabie, Paula Beatriz Araujo,
Various animals live in termite nests as secondary occupants. Among them are terrestrial isopods. We found five species of terrestrial isopods (Oniscidea) in 17 of 34 termite nests of Nasutitermes in a cocoa plantation near Ilhéus, Bahia, Brazil (in 2 aging and 15 abandoned nests). The 14 active, 1 aging and 2 abandoned nests bore no isopods. The oniscideans were Atlantoscia rubromarginata, an undescribed species of Atlantoscia (Philosciidae), Pudeoniscus birabeni, P. obscurus (Pudeoniscidae) and Neotroponiscus ...
Tópico(s): Animal Behavior and Reproduction
2013 - Fundação de Amparo à Pesquisa do Estado de SP | Biota Neopropica/Biota Neotropica
Patrick Thomaz de Aquino Martins, Erminda Conceição Guerreiro Couto, Jacques Hubert Charles Delabie,
The structural characterization of the mangrove vegetation bases conservation actions and is an important tool in the evaluation of the system reply to the c...
Tópico(s): Geography and Environmental Studies
2011 - | Revista de Gestão Costeira Integrada
... 1017/CBO9781107338357.016Jonathas Teixeira Lisboa, Erminda da Conceição Guerreiro Couto, Pollyanna Pereira Santos, Jacques Hubert Charles Delabie, Paula Beatriz Araujo, , , , , , Terrestrial isopods (Crustacea: Isopoda: ...
Tópico(s): Ecology and Vegetation Dynamics Studies
1942 - University of Chicago Press | The Quarterly Review of Biology
Bruno A. Benítez, Sheng Chih Jin, Rita Guerreiro, Rob Graham, Jenny Lord, Denise Harold, Rebecca Sims, Jean‐Charles Lambert, J. Raphael Gibbs, José Brás, Celeste Sassi, Oscar Harari, Sarah Bertelsen, Michelle K. Lupton, John Powell, Céline Bellenguez, Kristelle Brown, Christopher Medway, Patrick C. G. Haddick, Marcel P. van der Brug, Tushar Bhangale, Ward Ortmann, Tim Behrens, Richard Mayeux, Margaret A. Pericak‐Vance, Lindsay A. Farrer, Gerard D. Schellenberg, Jonathan L. Haines, James Turton, Anne Braae, Imelda Barber, Anne M. Fagan, David M. Holtzman, John C. Morris, Julie Williams, John S.K. Kauwe, Philippe Amouyel, Kevin Morgan, Andy Singleton, John Hardy, Alison Goate, Carlos Cruchaga,
TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on chromosome 6p21.11. Recent studies have identified a rare coding variant (p.R47H) in TREM2 that confers a high risk for Alzheimer's disease (AD). In addition, common single nucleotide polymorphisms in this genomic region are associated with cerebrospinal fluid biomarkers for AD and a common intergenic variant found near the TREML2 gene has been identified to be protective for AD. However, little is ...
Tópico(s): Immune cells in cancer
2013 - Elsevier BV | Neurobiology of Aging
Brian W. Kunkle, Benjamin Grenier‐Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J. van der Lee, Alexandre Amlie‐Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R. Martin, Kristel Sleegers, Nandini Badarinarayan, Jóhanna Jakobsdóttir, Kara L. Hamilton‐Nelson, Sonia Moreno‐Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B. Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N. Vardarajan, Jacques Epelbaum, Per Hoffmann, Merçé Boada, Gary W. Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L. Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V. Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C. Fox, Seung‐Hoan Choi, Ignacio Mateo, Joseph T. Hughes, Hieab H.H. Adams, John Malamon, Florentino Sanchez‐García, Yogen Patel, Jennifer A. Brody, Beth A. Dombroski, María Cándida Déniz Naranjo, Makrina Daniilidou, Guðný Eiríksdóttir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B. Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloé Sarnowski, William S. Bush, Stéphane Meslage, Johannes Kornhuber, Charles C. White, Yeunjoo E. Song, Robert C. Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M. Adams, Rik Vandenberghe, Manuel Mayhaus, L. Adrienne Cupples, Marilyn S. Albert, Peter Paul De Deyn, Wei Gu, J.J. Himali, Duane Beekly, Alessio Squassina, Annette M. Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodríguez‐Rodríguez, Simon Lovestone, Melissa E. Garcia, Rachelle S. Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas Fairchild, Yolanda A. Benito, Clive Holmes, Hata Karamujić‐Čomić, Matthew P. Frosch, Håkan Thonberg, Wolfgang Maier, Gennady V. Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M. Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J. Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C. Dirk Keene, Seppo Helisalmi, Iwona Kłoszewska, Walter A. Kukull, Anne M. Koivisto, Aoibhinn Lynch, Lluís Tárraga, Eric B. Larson, Annakaisa Haapasalo, Brian Lawlor, Sonia Thomas, Richard B. Lipton, Vincenzo Solfrizzi, Michael Gill, W. T. Longstreth, Thomas J. Montine, Vincenza Frisardi, Mónica Díez-Fairén, Fernando Rivadeneira, Ronald C. Petersen, Vincent Deramecourt, Ignacio Álvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M. Reiman, Nathalie Fiévet, Jerome I. Rotter, Joan Reisch, Olivier Hanon, Chiara Cupidi, André G. Uitterlinden, Donald R. Royall, Carole Dufouil, Raffaele Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George‐Hyslop, Karen Ritchie, Magda Tsolaki, Debby W. Tsuang, Bruno Dubois, David Craig, Chuang‐Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L. Albin, Laura Fratiglioni, Antonia Germanou, Liana G. Apostolova, Lina Keller, Maria Koutroumani, Steven E. Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice L. Whitehead, Craig Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ãngel Carracedo, Lars Lannfelt, David C. Rubinsztein, Lisa L. Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G. Beach, Janet Johnston, James T. Becker, Peter Passmore, Eileen H. Bigio, Jonathan M. Schott, Thomas D. Bird, Jason D. Warren, Bradley F. Boeve, Michelle K. Lupton, James D. Bowen, Petroula Proitsi, Adam Boxer, John Powell, James R. Burke, John S.K. Kauwe, Jeffrey M. Burns, Michelangelo Mancuso, Joseph D. Buxbaum, Ubaldo Bonuccelli, Nigel J. Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris Carlson, Nicholas Bass, Cynthia M. Carlsson, John Hardy, Regina M. Carney, José Brás, Minerva M. Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C. Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Neill R. Graff‐Radford, Denis A. Evans, Angela Hodges, Kelley M. Faber, Martin Scherer, Kenneth B. Fallon, Markus J. Riemenschneider, David W. Fardo, Reinhard Heun, Martin R. Farlow, Heike Kölsch, Steven H. Ferris, Markus Leber, Tatiana Foroud, Isabella Heuser, Douglas Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H. Geschwind, John R. Gilbert, John C. Morris, Robert C. Green, Kevin H. Mayo, John H. Growdon, Thomas Feulner, Ronald L. Hamilton, Lindy E. Harrell, Dmitriy Drichel, Lawrence S. Honig, Thomas D. Cushion, Matthew J. Huentelman, Paul Hollingworth, Christine M. Hulette, Bradley T. Hyman, Iain Marshall, Gail P. Jarvik, Alun Meggy, Erin L. Abner, Georgina Menzies, Lee‐Way Jin, Ganna Leonenko, Luís Miguel Real, Gyungah R Jun, Clinton T. Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jonathan Kaye, Ronald Kim, Frank Jessen, Neil W. Kowall, Bruno Vellas, Joel H. Kramer, Emma Vardy, Frank M. LaFerla, Karl‐Heinz Jöckel, James J. Lah, Martin Dichgans, James B. Leverenz,
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer’s or dementia. Fine-mapping ...
Nature Portfolio
Brian W. Kunkle, Benjamin Grenier‐Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J. van der Lee, Alexandre Amlie‐Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R. Martin, Kristel Sleegers, Nandini Badarinarayan, Jóhanna Jakobsdóttir, Kara L. Hamilton‐Nelson, Sonia Moreno‐Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N. Vardarajan, Jacques Epelbaum, Per Hoffmann, Merçé Boada, Gary W. Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L. Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V. Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C. Fox, Seung‐Hoan Choi, Ignacio Mateo, Joseph T. Hughes, Hieab H.H. Adams, John Malamon, Florentino Sanchez‐García, Yogen Patel, Jennifer A. Brody, Beth A. Dombroski, María Cándida Déniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B. Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloé Sarnowski, William S. Bush, Stéphane Meslage, Johannes Kornhuber, Charles C. White, Yeunjoo E. Song, Robert C. Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M. Adams, Rik Vandenberghe, Manuel Mayhaus, L. Adrienne Cupples, Marilyn S. Albert, Peter Paul De Deyn, Wei Gu, J.J. Himali, Duane Beekly, Alessio Squassina, Annette M. Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodríguez‐Rodríguez, Simon Lovestone, Melissa E. Garcia, Rachelle S. Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas Fairchild, Yolanda Aladro, Clive Holmes, Hata Karamujić‐Čomić, Matthew P. Frosch, Håkan Thonberg, Wolfgang Maier, Gennady V. Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M. Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M. Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J. Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C. Dirk Keene, Seppo Helisalmi, Iwona Kłoszewska, Walter A. Kukull, Anne M. Koivisto, Aoibhinn Lynch, Lluís Tárraga, Eric B. Larson, Annakaisa Haapasalo, Brian Lawlor, Sonia Thomas, Richard B. Lipton, Vincenzo Solfrizzi, Michael Gill, W. T. Longstreth, Thomas J. Montine, Vincenza Frisardi, Mónica Díez-Fairén, Fernando Rivadeneira, Ronald C. Petersen, Vincent Deramecourt, Ignacio Álvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M. Reiman, Nathalie Fiévet, Jerome I. Rotter, Joan Reisch, Olivier Hanon, Chiara Cupidi, André G. Uitterlinden, Donald R. Royall, Carole Dufouil, Raffaele Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George‐Hyslop, Karen Ritchie, Magda Tsolaki, Debby W. Tsuang, Bruno Dubois, David Craig, Chuang‐Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L. Albin, Laura Fratiglioni, Antonia Germanou, Liana G. Apostolova, Lina Keller, Maria Koutroumani, Steven E. Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice L. Whitehead, Craig Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ãngel Carracedo, Lars Lannfelt, David C. Rubinsztein, Lisa L. Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G. Beach, Janet Johnston, James T. Becker, Peter Passmore, Eileen H. Bigio, Jonathan M. Schott, Thomas D. Bird, Jason D. Warren, Bradley F. Boeve, Michelle K. Lupton, James D. Bowen, Petroula Proitsi, Adam Boxer, John Powell, James R. Burke, John Kauwe, Jeffrey M. Burns, Michelangelo Mancuso, Joseph D. Buxbaum, Ubaldo Bonuccelli, Nigel J. Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris Carlson, Nicholas Bass, Cynthia M. Carlsson, John Hardy, Regina M. Carney, José Brás, Minerva M. Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C. Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Caroline Graff, Denis A. Evans, Angela Hodges, Kelley M. Faber, Martin Scherer, Kenneth B. Fallon, Markus J. Riemenschneider, David W. Fardo, Reinhard Heun, Martin R. Farlow, Heike Kölsch, Steven H. Ferris, Markus Leber, Tatiana M. Foroud, Isabella Heuser, Douglas Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H. Geschwind, John R. Gilbert, John C. Morris, Robert C. Green, Kevin H. Mayo, John H. Growdon, Thomas Feulner, Ronald L. Hamilton, Lindy E. Harrell, Dmitriy Drichel, Lawrence S. Honig, Thomas D. Cushion, Matthew J. Huentelman, Paul Hollingworth, Christine M. Hulette, Bradley T. Hyman, Iain Marshall, Gail P. Jarvik, Alun Meggy, Erin L. Abner, Georgina Menzies, Lee‐Way Jin, Ganna Leonenko, Luís Miguel Real, Gyungah R Jun, Clinton T. Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jonathan Kaye, Ronald Kim, Frank Jessen, Neil W. Kowall, Bruno Vellas, Joel H. Kramer, Emma Vardy, Frank M. LaFerla, Karl‐Heinz Jöckel, James J. Lah, Martin Dichgans, James B. Leverenz,
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Nature Portfolio
Ana Mendanha Falcão, David van Bruggen, Sueli Marques, Mandy Meijer, Sarah Jäkel, Eneritz Agirre, S. Samudyata, Elisa M. Floriddia, Darya Vanichkina, Charles ffrench‐Constant, Anna Williams, André Ortlieb Guerreiro‐Cacais, Gonçalo Castelo‐Branco,
Multiple sclerosis (MS) is characterized by an immune system attack targeting myelin, which is produced by oligodendrocytes (OLs). We performed single-cell transcriptomic analysis of OL lineage cells from the spinal cord of mice induced with experimental autoimmune encephalomyelitis (EAE), which mimics several aspects of MS. We found unique OLs and OL precursor cells (OPCs) in EAE and uncovered several genes specifically alternatively spliced in these cells. Surprisingly, EAE-specific OL lineage populations ...
Tópico(s): Extracellular vesicles in disease
2018 - Nature Portfolio | Nature Medicine
Produção Nacional
Revisado por pares
Drausio Honório Morais, Maria Isabel Müller, Francisco Tiago de Vasconcelos Melo, Aline Aguiar, Yuri Willkens, Charles De Sousa Silva, Elane Guerreiro Giese, Róbson Waldemar Ávila, Reinaldo José da Silva,
Abstract Rhabdias pocoto n. sp. is herein described from the lungs of the swamp frog Pseudopaludicola pocoto Magalhães, Loebmann, Nogueira, Kokubum, Baptista, Haddad & Garda, 2014, from the Caatinga biome in the state of Ceará, in north-eastern Brazil. The new species is characterized by a body that dilates posteriorly, six small lips (protuberances) and two rounded lateral expansions of cuticular inflation on the anterior end, each containing an amorphous gland-like structure inside and a short and ...
Tópico(s): Amphibian and Reptile Biology
2020 - Cambridge University Press | Journal of Helminthology
Charles Gauthier, Pierre Chassagne, François‐Xavier Theillet, Catherine Guerreiro, Françoise Thouron, Farida Nato, Muriel Delepierre, Philippe Sansonetti, Armelle Phalipon, Laurence A. Mulard,
Synthetic functional mimics of the O-antigen from Shigella flexneri 2a are seen as promising vaccine components against endemic shigellosis. Herein, the influence of the polysaccharide non-stoichiometric di-O-acetylation on antigenicity is addressed for the first time. Three decasaccharides, representing relevant internal mono- and di-O-acetylation profiles of the O-antigen, were synthesized from a pivotal protected decasaccharide designed to tailor late stage site-selective O-acetylation. The latter ...
Tópico(s): Escherichia coli research studies
2014 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Produção Nacional
Revisado por pares
Yosbel R. Ortega, Igor M. Guerreiro, Dennis Hui, Charles C. Cavalcante, Francisco R. P. Cavalcanti,
Abstract The use of efficient beam tracking mechanisms becomes necessary in highly directional communication of the fifth‐generation systems. In this context, this paper analyzes the tracking problem and proposes a framework that exploits the samples in the user equipment (UE) dataset (historical UE dataset) to efficiently estimate and predict the channel state at the base station. The framework is composed of two steps. First, a supervised learning algorithm, namely, K ‐nearest neighbors ( K ‐NN), is ...
Tópico(s): Advanced Wireless Communication Techniques
2019 - | Transactions on Emerging Telecommunications Technologies
... http://history.nasa.gov/rogersrep/genindex.htm. Radey, Charles. 1990. Telling Stories: Creative Literature and Ethics. Hastings Center Report 20(6): 25. Ramos, Alberto Guerreiro. 1981. The New Science of Organizations: A Reconceptualization ...
Tópico(s): Ethics in medical practice
2004 - Wiley | Public Administration Review
Produção Nacional
Revisado por pares
Igor M. Guerreiro, Charles C. Cavalcante, Dennis Hui,
This work addresses a distributed technique to precoding matrices coordination in a multi-cell network. We propose an iterative method based on a message-passing algorithm in factor graphs. Finite precoder codebooks for different MIMO setups are adopted for beam forming purposes. Conversely, practical cellular networks usually solve the precoder selection problem in a non-iterative manner based on the best response method. Nevertheless, this method may not provide a near-optimal solution. For more ...
Tópico(s): Advanced Wireless Communication Techniques
2014 - IOP Publishing | IOP Conference Series Materials Science and Engineering
Produção Nacional
Revisado por pares
Carlos Eduardo Aliatti Mantese, Mariana Pontalti, Alexandre Guerreiro, Charles Klamt,
Most brainstem infarcts are caused by pontine strokes. When a bilateral pontine or brainstem stroke occurs, it can result in an image called the “heart appearance” sign. Sequential pontine strokes have not yet been described to cause the “heart appearance” sign. We report a case of sequential pontine strokes in a 47-year-old man with no relevant medical history. He presented with acute left-sided hemiparesis. Initial brain MRI showed a right-sided pontine infarction. Two weeks later, the patient’s ...
Tópico(s): Acute Ischemic Stroke Management
2021 - Cureus, Inc. | Cureus
Rita Guerreiro, Aleksandra Wojtas, José Brás, Minerva M. Carrasquillo, Ekaterina Rogaeva, Elisa Majounie, Carlos Cruchaga, Celeste Sassi, John Kauwe, Steven G. Younkin, Lili‐Naz Hazrati, John Collinge, Jennifer M. Pocock, Tammaryn Lashley, Julie Williams, Jean‐Charles Lambert, Philippe Amouyel, Alison Goate, Rosa Rademakers, Kevin Morgan, John Powell, Peter St George‐Hyslop, Andrew Singleton, John Hardy,
Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia.
Tópico(s): Neurological Disease Mechanisms and Treatments
2012 - Massachusetts Medical Society | New England Journal of Medicine
Charles Feldman, N C Munro, P K Jeffery, Timothy J. Mitchell, Peter W. Andrew, G J Boulnois, Daniela Guerreiro, J.A.L. Rohde, Howard Todd, Peter Cole, R Wilson,
Streptococcus pneumoniae infections are common, but how they cause host tissue injury and death is incompletely understood. Immunization with pneumolysin, a thiol-activated toxin produced by the pneumococcus, partially protects animals during subsequent infection. The mechanism by which pneumolysin contributes to disease is not known. The aim of the present investigation was to determine the histologic changes induced by recombinant pneumolysin in the rat lung and to compare them with the changes ...
Tópico(s): Respiratory viral infections research
1991 - American Thoracic Society | American Journal of Respiratory Cell and Molecular Biology
Catherine Schramm, Camille Charbonnier, Aline Zaréa, Morgane Lacour, David Wallon, Daniela Andriuta, Pierre Anthony, Sophie Auriacombe, Anna‐Chloé Balageas, Guillaume Ballan, Mélanie Barbay, É. Beaufils, Yannick Béjot, Serge Belliard, Marie Bénaiteau, Karim Bennys, Frédéric Blanc, Stéphanie Bombois, Claire Boutoleau Bretonnière, Pierre Branger, Jasmine Carlier, Leslie Cartz‐Piver, Pascaline Cassagnaud, Giovanni Castelnovo, Christine Champion, Annabelle Chaussenot, Mathieu Ceccaldi, Valérie Chauviré, Yaohua Chen, Julien Cogez, Emmanuel Cognat, Fabienne Contégal-Callier, Léa Corneille, Philippe Couratier, Hélène Courtemanche, Benjamin Cretin, C. Crinquette, Bernard Croisille, Benjamin Dauriat, Sophie Dautricourt, Vincent de La Sayette, Astrid De Liège, Marie De Verdal, Didier Deffond, Benoît Delpont, Florence Démurger, Vincent Deramecourt, Céline Derollez, Mira Didic, Giulia Diemert, Elsa Dionet, Philippe Diraison, Aude Doan, Martine Doco Fenzy, Boris Dufournet, Julien Dumurgier, Hélène Durand, Anaïs Dutray, Frédérique Etcharry‐Bouyx, Maïté Formaglio, Audrey Gabelle, Anne Gainche-Salmon, Jean‐Claude Getenet, Emmanuelle Ginglinger, Olivier Godefroy, Mathilde Graber, Chloé Gregoire, Stéphan Grimaldi, Julien Guéniat, Claude Guériot, Sophie Haffen, Lorraine Hamelin, Didier Hannequin, Cezara Hanta, Clémence Hardy, Geoffroy Hautecloque, Camille Heitz, Claire Hourrègue, Thérèse Jonveaux, Snejana Jurici, Catia Khoumri, Lejla Koric, Pierre Krolak‐Salmon, Pierre Labauge, Morgane Lacour, Julien Lagarde, Hélène-Marie Lanoiselée, Brice Laurens, Isabelle Le Ber, Gwenaël Le Guyader, Amélie Leblanc, Thibaud Lebouvier, Anaïs Lippi, Marie‐Anne Mackowiak, Éloi Magnin, Cécilia Marelli, Olivier Martinaud, Aurélien Maureille, Emilie Milongo-Rigal, Sophie Mohr, Hélène Mollion, Olivier Moreaud, Alexandre Morin, Gaël Nicolas, Julia Nivelle, Camille Noiray, Elisabeth Ollagnon‐Roman, Claire Paquet, Jérémie Pariente, Florence Pasquier, Alexandre Perron, Nathalie Philippi, Virginie Pichon, Vincent Planche, Céline Poirsier, Marie Rafiq, Pauline Rod-Olivieri, Adeline Rollin‐Sillaire, Carole Roué-Jagot, Dario Saracino, Marie Sarazin, Mathilde Sauvée, François Sellal, Lila Sirven Villaros, Christel Thauvin, Camille Tisserand, Christophe Tomasino, Cédric Turpinat, Laurène Van Damme, Olivier Vercruysse, Alice Voilly, Nathalie Wagemann, David Wallon, Aline Zaréa, Anne Boland, Jean‐François Deleuze, Robert Olaso, Shahzad Ahmad, Philippe Amouyel, Claudine Berr, Anne Boland, Paola Bossù, Femke H. Bouwman, José Brás, Dominique Campion, Camille Charbonnier, Jordi Clarimón, Antonio Daniele, Jean‐François Dartigues, Stéphanie Debette, Jean‐François Deleuze, Nicola Denning, Oriol Dols‐Icardo, Nick C. Fox, Daniela Galimberti, Emmanuelle Génin, Gilles Thomas, Benjamin Grenier‐Boley, Detelina Grozeva, Rita Guerreiro, John J. Hardy, Clive Holmes, Henne Holstege, Marc Hulsman, Holger Hummerich, M. Arfan Ikram, M. Kamran Ikram, Iris E. Jansen, Amit Kawalia, Robert Kraaij, Jean‐Charles Lambert, M Lathrop, Afina W. Lemstra, Alberto Lleó, Lauren Luckcuck, Marcel M.A.M. Mannens, Iain Marshall, Carlo Masullo, Simon Mead, Patrizia Mecocci, Alun Meggy, Merel O. Mol, Kevin Morgan, Benedetta Nacmias, Gaël Nicolas, Penny J. Norsworthy, Florence Pasquier, Pau Pástor, Olivier Quenez, Alfredo Ramı́rez, Rachel Raybould, Richard Redon, Marcel J. T. Reinders, Anne‐Claire Richard, Steffi G. Riedel‐Heller, Fernando Rivadeneira, Stéphane Rousseau, Natalie S. Ryan, Salha Saad, Pascual Sánchez‐Juan, Philip Scheltens, Jonathan M. Schott, Davide Seripa, Daoud Sie, Rebecca Sims, Erik A. Sistermans, Sandro Sorbi, Resie van Spaendonk, Gianfranco Spalleta, Niccoló Tesi, Betty M. Tijms, André G. Uitterlinden, Wiesje M. van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Jeroen van Rooij, John C. van Swieten, Pieter Jelle Visser, Michael Wagner, David Wallon, Julie Williams, Aline Zaréa, Flora Alarcon, Dominique Campion, Grégory Nuel, Gaël Nicolas,
Abstract Background Alzheimer disease (AD) is a common complex disorder with a high genetic component. Loss-of-function (LoF) SORL1 variants are one of the strongest AD genetic risk factors. Estimating their age-related penetrance is essential before putative use for genetic counseling or preventive trials. However, relative rarity and co-occurrence with the main AD risk factor, APOE -ε4, make such estimations difficult. Methods We proposed to estimate the age-related penetrance of SORL1 -LoF variants ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2022 - BioMed Central | Genome Medicine
Produção Nacional
Revisado por pares
João Pedreira Duprat Neto, Ana Carolina C. Mauro, André Sapata Molina, Kenji Nishinari, Charles Edouard Zurstrassen, O. F. Costa, Francisco Aparecido Belfort, Luciana Facure, José Humberto Tavares Guerreiro Fregnani,
Background The isolated limb infusion (ILI) technique is a simpler and less invasive alternative to isolated limb perfusion, which allows regional administration of high-dose chemotherapy to patients with advanced melanoma and other malignancies restricted to a limb. Methods Patients from two institutions, treated by ILI between 1998 and 2009 for extensive disease restricted to a limb, were included. The cohort included 31 patients with melanoma who presented with in-transit metastases or an extensive ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2012 - Wiley | ANZ Journal of Surgery
Laurie Robak, Iris E. Jansen, Jeroen van Rooij, André G. Uitterlinden, Robert Kraaij, Joseph Jankovic, Peter Heutink, Joshua Shulman, Mike A. Nalls, Vincent Plagnol, Dena G Hernandez, Manu Sharma, Una‐Marie Sheerin, Mohamad Saad, Javier Simón‐Sánchez, Claudia Schulte, Suzanne Lesage, Sigurlaug Sveinbjörnsdóttir, Sampath Arepalli, Roger A. Barker, Yoav Ben-, Henk W. Berendse, Daniela Berg, Kailash P. Bhatia, Rob M.A. de Bie, Alessandro Biffi, Bas R. Bloem, Zoltán Bochdanovits, Michael Bonin, José Brás, Kathrin Brockmann, Janet Brooks, David J. Burn, Elisa Majounie, Gavin Charlesworth, Codrin Lungu, Honglei Chen, Patrick F. Chinnery, Sean Chong, Carl E Clarke, Mark Cookson, Jonathan M. Cooper, Jean‐Christophe Corvol, Carl Counsell, Philippe Damier, Jean‐François Dartigues, Panos Deloukas, Günther Deuschl, David T. Dexter, Karin D. van Dijk, Allissa Dillman, F. Durif, Alexandra Dürr, Sarah Edkins, Jonathan Evans, Thomas Foltynie, Jing Dong, Michelle Gardner, J. Raphael Gibbs, Alison Goate, Emma Gray, Rita Guerreiro, Clare Harris, Jacobus J. van Hilten, Albert Hofman, Albert R. Hollenbeck, Janice L. Holton, Joshua Shulman, Joshua Shulman, Isabel Wurster, Walter Mätzler, Gavin Hudson, Sarah Hunt, Johanna Huttenlocher, Thomas Illig, Pálmi V. Jónsson, Jean‐Charles Lambert, Cordelia Langford, Andrew J. Lees, Peter Lichtner, Patricia Limousin, Grisel Lopez, Delia Lorenz, Codrin Lungu, Alisdair McNeill, Catriona Moorby, Matthew Moore, Huw R. Morris, Karen Morrison, Valentina Escott‐Price, Ese Mudanohwo, Sean S. O’Sullivan, Justin Pearson, Joel S. Perlmutter, Hjörvar Pétursson, Pierre Pollak, Bart Post, Simon Potter, Bernard Ravina, Tamás Révész, Olaf Rieß, Fernando Rivadeneira, Patrizia Rizzu, Mina Ryten, Stephen Sawcer, Anthony H.V. Schapira, Hans Scheffer, Karen Shaw, Ira Shoulson, Joshua Shulman, Ellen Sidransky, Colin Smith, Chris C. A. Spencer, Hreinn Stefánsson, Francesco Bettella, Joanna D. Stockton, Amy Strange, Kevin Talbot, Carlie M. Tanner, Avazeh Tashakkori-Ghanbaria, François Tison, Daniah Trabzuni, Bryan J. Traynor, André G. Uitterlinden, Daan C. Velseboer, Marie Vidailhet, Robert Walker, Bart van de Warrenburg, Mirdhu Wickremaratchi, Nigel Williams, Caroline H. Williams‐Gray, Sophie Winder‐Rhodes, Kári Stéfansson, María Martínez, Nicholas Wood, John Hardy, Peter Heutink, Alexis Brice, Thomas Gasser, Andrew Singleton,
Mutations in the glucocerebrosidase gene (GBA), which cause Gaucher disease, are also potent risk factors for Parkinson's disease. We examined whether a genetic burden of variants in other lysosomal storage disorder genes is more broadly associated with Parkinson's disease susceptibility. The sequence kernel association test was used to interrogate variant burden among 54 lysosomal storage disorder genes, leveraging whole exome sequencing data from 1156 Parkinson's disease cases and 1679 control ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2017 - Oxford University Press | Brain
Jacinta Alchouron, Amalia Lara Bursztyn Fuentes, Carolina Guerreiro, Karina Hodara, Martín N. Gatti, Charles U. Pittman, Todd Mlsna, Hugo D. Chludil, Andrea S. Vega,
Feedstock characteristics impact biochar physicochemical properties, and reproducible biochar properties are essential for any potential application. However, in most articles, feedstock aspects (i.e., taxonomic name of the species, part of the plant, and phenological phase) are scarcely reported. This research aimed at studying the effect of species and phenological stage of feedstock on the properties of the derived biochars and, thus, adsorption capacities in water treatment. In this study, we ...
Tópico(s): Adsorption and biosorption for pollutant removal
2024 - Elsevier BV | Chemosphere
A Beilina, Iakov N. Rudenko, Alice Kaganovich, Laura Civiero, Hien Chau, Suneil K. Kalia, Lorraine V. Kalia, Evy Lobbestael, Ruth Chia, Kelechi Ndukwe, Joshua Shulman, Mike A. Nalls, Maciej B. Olszewski, David N. Hauser, Ravindran Kumaran, Andrés M. Lozano, Veerle Baekelandt, Lois E. Greene, Jean‐Marc Taymans, Elisa Greggio, Mark Cookson, Mike A. Nalls, Vincent Plagnol, María Martínez, Dena G. Hernandez, Manu Sharma, Una‐Marie Sheerin, Mohamad Saad, Javier Simón‐Sánchez, Claudia Schulte, Suzanne Lesage, Sigurlaug Sveinbjörnsdóttir, Sampath Arepalli, Roger A. Barker, Yoav Ben–Shlomo, Henk W. Berendse, Daniela Berg, Kailash P. Bhatia, Rob M.A. de Bie, Alessandro Biffi, Bas R. Bloem, Zoltán Bochdanovits, Michael Bonin, José Brás, Kathrin Brockmann, Janet Brooks, David J. Burn, Gavin Charlesworth, Honglei Chen, Sean Chong, Carl E Clarke, Mark Cookson, Jonathan M. Cooper, Jean‐Christophe Corvol, Carl Counsell, Philippe Damier, Jean‐François Dartigues, Panos Deloukas, Günther Deuschl, David T. Dexter, Karin D. van Dijk, Allissa Dillman, F. Durif, Alexandra Dürr, Sarah Edkins, Jonathan Evans, Thomas Foltynie, Jianjun Gao, Michelle Gardner, J. Raphael Gibbs, Alison Goate, Emma Gray, Rita Guerreiro, Ómar Gústafsson, Clare Harris, Jacobus J. van Hilten, Albert Hofman, Albert R. Hollenbeck, Janice L. Holton, Joshua Shulman, Xuemei Huang, Heiko Huber, Gavin Hudson, Sarah Hunt, Johanna Huttenlocher, Thomas Illig, Helmholtz Zentrum München, Pálmi V. Jónsson, Jean‐Charles Lambert, Cordelia Langford, Andrew J. Lees, Peter Lichtner, Helmholtz Zentrum München, Patricia Limousin, Grisel Lopez, Delia Lorenz, Alisdair McNeill, Catriona Moorby, M. Elyse Moore, Huw R. Morris, Karen Morrison, Ese Mudanohwo, Sean S. O’Sullivan, Justin Pearson, Joel S. Perlmutter, Hjörvar Pétursson, Pierre Pollak, Bart Post, Simon Potter, Bernard Ravina, Tamás Révész, Olaf Rieß, Fernando Rivadeneira, Patrizia Rizzu, Mina Ryten, Stephen Sawcer, Anthony H.V. Schapira, Hans Scheffer, Karen Shaw, Ira Shoulson, Ellen Sidransky, Colin Smith, Chris C. A. Spencer, Hreinn Stefánsson, Stacy Steinberg, Joanna D. Stockton, Amy Strange, Kevin Talbot, Carlie M. Tanner, Avazeh Tashakkori-Ghanbaria, François Tison, Daniah Trabzuni, Bryan J. Traynor, André G. Uitterlinden, Daan C. Velseboer, Marie Vidailhet, Robert Walker, Bart van de Warrenburg, Mirdhu Wickremaratchi, Nigel Williams, Caroline H. Williams‐Gray, Sophie Winder‐Rhodes, Kári Stéfansson, John Hardy, Peter Heutink, Alexis Brice, Thomas Gasser, Andrew Singleton, Nicholas Wood, Patrick F. Chinnery, Sampath Arepalli, Mark Cookson, Allissa Dillman, Luigi Ferrucci, J. Raphael Gibbs, Dena G. Hernandez, Robert Johnson, Dan L. Longo, Elisa Majounie, Michael A. Nalls, Richard F. OʼBrien, Andrew Singleton, Bryan J. Traynor, Juan C. Troncoso, Marcel van der Brug, H. Ronald Zielke, Alan B. Zonderman,
Significance Understanding loci nominated by genome-wide association studies (GWASs) is challenging. Here, we show, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci. This result illustrates a significant general principle that will likely apply across multiple diseases.
Tópico(s): Lysosomal Storage Disorders Research
2014 - National Academy of Sciences | Proceedings of the National Academy of Sciences