Giles Smith, Andrew Robson, Alyn Shipton, Christina Hardyment, Jon Ashworth, R. N. Noble, Angela Kilmartin, Joanna Hunter, Robert Cole, David Cox, Andrew Pierce, DJM, Frances Gibb Legal Editor, Gary Duncan, John Doughty, Peter Lansley, Robert Fearnley, Richard Hobson, Tamora Langley, Philip Howard, Ian Cobain, Stewart Tendler and Daniel McGrory, David Chater, Tom Baldwin, Tony Halpin and Rosemary Bennett, James Bone, Penny Wark, Nic Hopkins, Alexandra Frean Social Affairs Correspondent, Sheila Johnston, Graham Breeze, Gillian Harris Scotland Correspondent, S. M. Hardy, Richard Cleroux, Wendy Ide, James Hider, Geoff Brown, Gerald Davies, Jim Dixon, Alexander Osborne, Dominic Clifford, Joe Joseph, Peter Brown, Sam Lister, David Sharrock, Antonia Senior, Tom Baldwin and Greg Hurst, Natalie Bennett, Pat Gibson, David McVay, Kevin Burdekin, Valerie Elliott, Gordon Johnson, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Dominic Walsh, James Doran Wall Street Correspondent, Joe Morgan, Jill Dupleix, Daniel Finkelstein, Jonathan Gornall, Nicholas Wapshott and Sam Lister, Robin Young, Alan Hamilton, Richard Miles and Antonia Senior, Richard Larner, Matt Dickinson and John Goodbody, Anatole Kaletsky, Valerie Elliott Consumer Editor, Roland Watson, Jonathan Richards, Matt Dickinson Chief Football Correspondent, Mark Souster and David Hands, Chris Horton, Patience Wheatcroft Business Editor, Hugo Rifkind, Alison Davis, Angela Jameson, Geoffrey Silman, Daniel McGrory, Oliver Kay, Irene Zoech and Sam Lister, Michael Theodoulou, Lesley Close, Rick Broadbent, Jill Sherman Whitehall Editor, Sam Coates, Mark Henderson Science Correspondent, Holly Finn, Ann Treneman, Rob Wright, Elaine Monaghan, Neil Harman Tennis Correspondent, Raymond Keene, Ian Evans, Adam Sage, Christine Buckley, Lewis Smith, Matthew Pryor, Stephen Lambert, Richard Miles Investment Editor, Philip Whiteley, Charles Elphicke, Christine Buckley Industrial Editor, Charles Wylie, Beryl Dixon, Greg Hurst Parliamentary Correspondent, Chris Campling, Bronwen Maddox, Kevin Mahony, Russell Hotten, Cathy Harris, Christopher Martin-Jenkins Chief Cricket Correspondent, Roger Boyes, Peter Dixon, Nick Hasell, Sam Wong, Tom Dart, Adam Fresco, Hugo Robson, Robert J. Taylor, Anna Frame, John Goodbody, Dominic Kennedy, Geoffrey White, Jonathan Clayton, Melissa Kite Political Correspondent, Christopher Walker, Ronald Eyres, Mel Webb, David Madel, Anjana Ahuja, Chris McGrath, George Caulkin, Ingrid Mansell, Alan Lee, Peter Riddell, Tony Dawe, Richard Beeston Diplomatic Editor, Richard Miles, Lea Paterson, Michael Irwin, Gary Duncan Economics Correspondent, Martin Waller, Chris Ayres, Christopher Irvine, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Stephen Dalton, Dr Thomas Stuttaford, Hugh Thompson, Leo Lewis, Neil Hunt, James Christopher, Tony Halpin, Gordon Brown, Abigail Rayner, Michael Evans, Randy Cohen, J. Clarkin, Peter J. Smith, Jenny Davey, Richard Beeston, Diplomatic Editor, Patience Wheatcroft, Nick Meo, Joe Bolger, Lisa Verrico,
... That was Ma Interview a Former Red Guard, Chen Kaige Casts his Eye over China Today, Says Sheila ...
2003 - Gale Group | TDA
Jackie Chan Joan Chen Kaige Chen Leslie Cheung Gong Li Andy Lau Ang Lee Bruce Lee Wong Kar-Wai John Woo Michelle Yeoh Zhang Yimou A ...
Tópico(s): Hong Kong and Taiwan Politics
1999 - Association of College and Research Libraries | Choice Reviews Online
William Leith, Barry Pickhall, Jane Dobija, Graham Rock, Clifford Longley, Vivien Goldsmith Family Money Editor, Andrew McEwen, Catherine Bennett, Patricia Davies, Judy Kirby, Malcolm Williamson, Jane MacQuitty, Simon Barnes, Cliff Feltham, Tom Lubbock, Stephen Pettit, Keith Speed, Hilary Finch, Cyril Jarvis, Ian Murray, Michael Binyon, Jeremy Kingston, Andrew McEven and John Best, Findlay Davidson, Edward Jay Epstein, Jeremy Flint, Marion Shoard, Richard Streeton, Bridget Frost, Clifford Longley, Religious Affairs Editor, Deyan …, Mario Modiano, Tony Patrick, Geoff Brown, J. G, Michael Seely Racing Correspondent, Vivien Goldsmith, Francesca Greenoak, Nicholas Davies, Henry Gee, Jim Railton, Graeme Rainey (President), Harry Debelius and Richard Evans, David Gould, Derek Brewer, Master, Roland Rudd, Employment Affairs Reporter, David Hawkins, Richard Dunn, Chairman, Robin Oakley Politcial Editor, Louise Taylor, Roland Rudd Employment Affairs Reporter, Peter Waymark, Michael Evans, Defence Correspondent, J. F, Robin Young, Robert Nye, David Butler, Jenny MacArthur, Michael Clark, Philip Robinson, Frances Bissell, Charles Bremner, John Percival, Fiona MacCarthy, Charles Knevitt Architecture Correspondent, John Hennessy, Humphrey Hawksley, Keith Robinson, Simon Tait, Jonathan Halford, Michael McCarthy Environment Correspondent, Brian Sedgemore, Rex Bellamy Tennis Correspondent, Harry Debelius, Edward Gorman, Irish Affairs Correspondent, (MIchael Phillips), Sydney Friskin, Hamish Lennox, David Miller, Nigel Andrew, Barry Millington, Philip Webster, Chief Political Correspondent, J. C. Winther, Wolfgang Münchau, Philip Hebbert, Kerry Gill, Raymond Keene, Peter Davalle, Geoff King, Emma Wilkins, Nicholas Beeston, Christopher Mosey, R. W. K. Paterson, Mollie Butler, Craig Brown, Paul Griffiths, Steve Acteson, Andrew McEwen, Diplomatic Correspondent, Peter Bryan, Richard Evans, Robin Neillands, Russell Davies, Martin Trew, L. Emerton, John Blunsden, Stewart Tendler, Crime Reporter, Richard Ford, Legal Affairs Reporter, Ned Sherrin, Pat Butcher, R. G. J. Ottaway, David Sapsted, Michael Platts Golf Correspondent, Simon Tait, Arts Correspondent, Ian Roddie, Kenneth Fleet, David Brewerton, John Goodbody, Ian Smith, Christopher Walker, Brian Alderson, Mel Webb, John Lewis and David Sapsted, Matthew Parris, Louise Tookey, Alan Franks, Keith Blackmore, Jenny Gilbert, Archie Tait, Catherine Adams, Richard Bassett, Budapest, David Sinclair, Stephen Pettitt, Martin Waller, Charles Hennessy, Jonathan Meades, D. Ellis Evans, David Tytler, Education Editor, Pat Butcher Athletics Correspondent, Jack Bailey, Rosalind Miles, Nigel Jamieson, Susan MacDonald, Maria Scott, J. H. Binfield, Headmaster, Frank Field, Conal Gregory, Judy Froshaug, Jeremy Andrews and David Tweed, David Hands, Rugby Correspondent, Peter Evans, Home Affairs Correspondent, Mary Dejevsky, Robert Kilroy-Silk, Philip Ray, Harry Debelius and Graham Searjeant, Richard Williams,
... of the Children & the New Chinese Cinema By Chen Kaige & Tony Rayns Faber, £5.99 Calling women names ...
1989 - Gale Group | TDA
Qiu-Mei Yang, Y.C. Lin, Jianzheng Guo, Chao Wang, Zijian Chen, Kaige Chen, Juncheng Zhu,
The spheroidization behavior of γ′ phase and dynamic recrystallization (DRX) mechanisms of a novel HIPed powder metallurgy (P/M) superalloy deformed at high temperatures (1080−1170 ℃) and different strain rates (1–0.001 s−1) are investigated. The results show that the spheroidization behavior of γ' phase and DRX mechanisms are greatly influenced by deformation condition. The coarse γ′Ⅰ phase promotes the DRX process, while the fine spherical γ'Ⅲ phase results in the formation of sub-grain boundaries. Thus, ...
Tópico(s): Microstructure and mechanical properties
2022 - Elsevier BV | Journal of Alloys and Compounds
Young Executive Chairman, Helen Johnstone, Beloff, Gillian Bowditch Scotland Correspondent, Edward Petch, Rob Hughes, David Adams and our Foreign Staff, T. H. Hughes-Davies, Robert Gilbert, Bill Frost, Helen Szamuely, Judy Hamilton Headteacher, Philip Howard, Ian Murray, Michael Binyon, Alexandra Frean Media Correspondent, Jeremy Kingston, Srecko Latal of Associated Press in Sarajevo, Lynne Truss, Carl Mortished, Nick Nuttall, Environment Correspondent, Sara McConnell, Personal Finance Correspondent, Gerald Davies, Thunderer, Bernard Levin, Martin Fletcher, Stewart Tendler Crime Correspondent, David Gould, Alan Lorimer, Peter Ball, Debra Craine, John O'leary, Education Editor, Nicholas Watt, Ireland Correspondent, Raymond Keene Chess Correspondent, Rob Hughes Football Correspondent, Peter Bills, Michael Evans, Defence Correspondent, Elaine Fogg, Philip Robinson, John Young, Michael Hamlyn, Keith Pike, Simon Helffer, Aileen Ballantyne, C. J. Golding, Susan Gilchrist, Richard Cork, John M. Cook, Robert Kirley, Nicholas Harling, Peter H. Field, John Hopkins, David Miller, Neil, MacKinnon, Raymond Keene, John Ashworth, David Robinson, Peter Davalle, Alan Lee, Cricket Correspondent, John Russell Taylor, Emma Wilkins, Harvey Elliot, Frances Gibb, Legal Correspondent, Paul Whitfield, Michael Dynes, Whitehall Correspondent, Charles Bremner and Nick Nuttall, Rodney Masters, Oliver Holt, David Pannick QC, Nicholas Watt and Philip Webster, Janet Bush Economics Correspondent, Leon S. Bennett, Philip Webster, Political Editor, David Hands Rugby Correspondent, Julian Muscat, George Austin, John Goodbody, R. H. Nicholson, Giles Whittell, Jack L. Crosby, P. Hendicott, Richard Evans Racing Correspondent, `, Ben MacIntyre, Ali Jaber and Alfred Hermida, Tony Dawe, Richard Beeston, Brian Auld, Rabbi Sidney Brichto, Philip Pangalos, Kate Bassett, Sarah Jane, Marianne Curphey, Dr Thomas Stuttaford, David Adams, Latin America Correspondent, Michael Evans Defence Correspondent, David Powell, Frances Gibb, Sam Kiley, Michael Hornsby, Countryside Correspondent, Michael Henderson, Lindsay Cook Deputy Business Editor, Peter Robinson, S. Grantham, Jonathan Mirsky, Julian Jacobs (Cabinet Member), Richard Bidgood, Robert McGeehan (Assistant Director),
... Times Pattering at the Great Wall of fear Chen Kaige makes films that explain to himself, to the ...
1994 - Gale Group | TDA
Pengfei Fang, Xue Yu, Seung Jae Jeong, Adam C. Mirando, Kaige Chen, Xin Chen, Sung‐Hoon Kim, Christopher S. Francklyn, Min Guo,
Abstract The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). How borrelidin simultaneously attenuates bacterial growth and suppresses a variety of infections in plants and animals is not known. Here we show, using X-ray crystal structures and functional analyses, that a single molecule of borrelidin simultaneously occupies four distinct subsites ...
Tópico(s): Genomics and Phylogenetic Studies
2015 - Nature Portfolio | Nature Communications
Jon Ashworth, David Adams, Helen Johnstone, Simon Barnes, Robert Morgan Political Staff, Alexandra Frean, Media Correspondent, C. F. Packham, Harvey Elliott, Michael Waudby, Richard Thomas, Lindsay Cook and Ian Murray, Andrew Warren, Director, Ross Tieman, Industrial Correspondent, Philip Howard, Wendy Miller, Ian Murray, Michael Binyon, Jeremy Kingston, Joseph Williams, Roger Barking, Clive Davis, Jenny Knight, John Franks, Colin Narbrough, World Trade Correspondent, Colin Narbrough, Geoff Brown, Adam Thomson, Martin Fletcher, George Ross, John O'leary Education Editor, F. Longanesi Cattani, John Hopkins, Golf Correspondent, Alan Lorimer, Alan Howells, Raymond Keene Chess Correspondent, Rob Hughes Football Correspondent, C. L. Loyd, Edwin Brigden, Kenneth C. Calman, Chief Medical Officer, Peter Waymark, Sir Ron Dearing, Tim Judah Balkans Correspondent, Colin Welch, Peter Millar, Daniel Johnson, Rodney Milnes, Robert Nye, Robert Bruce, Michael Clark, John Young, Anatole Kaletsky, Keith Pike, John Charnley, David Hands, Ian McIntyre, D. J. Chamberlain, Philip Bassett, Industrial Editor, Mary Teasdale, Susan Gilchrist, Arnold H. Beckett, Peter Ball and Keith Pike, John Woodcock, Lindsay Cook, Deputy Business Editor, George Brock, Janet Daley, Sydney Friskin, Gerry Acher, David Miller, Lin Jenkins, Gillian Bowditch, Stanley J. Blenkinsop, E. F. Boosey, R. W. Wheatley, Simon Heffer, Charles Bremner, Michael Evans, Defence Correspondent and Joel Brand, Raymond Keene, Rose Wild, Personal Finance Editor, Alan Lee, Cricket Correspondent, Emma Wilkins, Paul Wilkinson, Richard Evans, Marianne Curphey and Edward Gorman, Stephanie Biden, Barry Pickthall, Erica Wagner, Nigel Hawkes, Science Editor, John O'leary and Ben Preston, Janet Bush Economics Correspondent, Nicholas Boyle, Michael D. Wright, Tony Rocca, Ben MacIyre and Giles Whittell, Martin Fletcher and Michael Evans, Christopher Thomas, Dr James Le Fanu, William Rees-Mogg, Dominic Kennedy, N. M. Jordan, Philip Webster Political Editor, Rob Hughes, Football Correspondent, Pamela Walters, Peter Riddell, Ben MacIntyre, Richard Beeston, Philip Webster, John Lewis, Benedict Nightingale, Tom Rhodes, Dr Thomas Stuttaford, Marianne Curphey, Paul Kelbie, Richard Morrison, David Powell, Michael Henderson, Michael Evans, Ian Robertson, John Phillips, Stuart MacLure, Colin McQuillan, Jonathan Mirsky, Christopher Irvine, Sarah Bagnall Insurance Correspondent,
... at the Peking Opera Cinema: Geoff Brown reviews Chen Kaige's colourful epic and De Palma's latest ...
1994 - Gale Group | TDA
Pengfei Fang, Hongyan Han, Jing Wang, Kaige Chen, Xin Chen, Min Guo,
Pharmaceutical inhibitors of aminoacyl-tRNA synthetases demand high species and family specificity. The antimalarial ATP-mimetic cladosporin selectively inhibits Plasmodium falciparum LysRS (PfLysRS). How the binding to a universal ATP site achieves the specificity is unknown. Here we report three crystal structures of cladosporin with human LysRS, PfLysRS, and a Pf-like human LysRS mutant. In all three structures, cladosporin occupies the class defining ATP-binding pocket, replacing the adenosine ...
Tópico(s): Genomics and Phylogenetic Studies
2015 - Elsevier BV | Chemistry & Biology
Nibor, Phil Yates, Cath Urquhart, Sally Staples, Andrew Eames, Stella Shamoon, Helen Johnstone, Nick Nuttall Environment Correspondent, Robert Cole, A. M. Maud, nigella lawson, Catherine Riley, Andrew Pierce, James Moore, Patricia Davies, Grace Bradberry, Dave Gorman, Jane MacQuitty, Simon Barnes, John Morgan, Stella McCartney, David hands Rugby Correspondent, Joan South, Amy Barry, Emma Haughton, Richard Hobson, Martin Richards, Ann M. Risman, Ivo Tennant, Claire Foot, Douglas Friedli, Jonathan Wingfield, Kate Reardon, Howard Royse, Elizabeth Judge, Lynne Truss, Carl Mortished, Sharon Linnard, Dominic Bradbury, Jeremy Whittle, john diamond, Kevin Eason, Rosemary Carter, Chairman, Nick Szczpanik, Clare Stewart, Chris Hulme, Antonia Senior, Pat Gibson, Darcey Bussell, D. R., Steve Keenan, Thrasy Petropoulos, David Charter Education Correspondent, Dominic Walsh, Steve Bird, Jerome Boyd Maunsell, sandra hempel, Alix Ramsay Tennis Correspondent, E. C., Antony Fathers, Carol Price, Richard Ford Home Correspondent, Anthony Thorpe, Jo Morris, Robin Young, Helen Rumbelow and Tom Baldwin, Rodney Milnes, Michael Backman, Nick Wyke, Helen Rumbelow Medical Reporter, Sue Corbett, Valerie Elliott Consumer Editor, Frances Bissell, Michael Watts, Patrick Dodd, P. B., Christopher Martin Jenkins, Martin Symington, Peter Barnard, Anthea Lawson, David Charter, Tim Teeman, Caroline Merrell Banking Correspondent, Derwent May, Russell Kempson, Mary Gold, Ed Potton, Paul Armstrong, Caroline Cox, kevin Eason, Nigel Williamson, Stephen Anderton, clare stewart, Phil Yates and Patricia Davies, Tom Baldwin, John Hopkins, Christopher Martin-Jenkins, L. G., Tom Baldwin and Melissa Kite, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, David Powell Athletics Correspondent, Raymond Keene, Vaughan Freeman, Gareth Huw Davies, David Robinson, Clive Mathieson, Matthew Pryor, John Russell Taylor, Paul Wilkinson, Christine Buckley Industrial Editor, James Allcock, Peter Page, St Andrews Diary, Wayne Hemingway, Jeannette Hyde, Min Cooper, Christopher Walker Chief Ireland Correspondent, Bronwen Maddox, Chris Ayres Media Business Correspondent, Cathy Harris, J. R. Brett, Michael Arditti, Oliver Holt, Helen Nugent, Shane Warne, Rob Chapman, Damian Whitworth, Clare Sterling, David Kettle, Sarah Litvinoff, John Stern, Oliver August, Noel Gallagher, Philip August, David Hands Rugby Correspondent, Celestria Noel, Glen Owen, Adam Fresco, BN, Nick Szczepanik, John Goodbody, Mary Ann Sieghart, James Doran, Giles Whittell, Philip Webster Political Editor, Jane Shilling, Alex O'Connell, Mel Webb, Anthony Field, Gwenda Brophy, Matthew Parris, Jennai Cox, Richard Scribner, Chris McGrath, Tim Wapshott, Michael Austin, Jane Owen, Hunter Davies, Helen Pridham, Ian Brodie, Bernard Silk, Michael Dynes, Philip Webster, Graham Searjeant, David Sinclair, Richard Miles, JRT, Martin Waller, Elizabeth Cowley, Michael Horsnell, Danny Baker, Fran Littlewood, Mark Baldwin, Benedict Nightingale, Penny Tucker, Dr Thomas Stuttaford, Jill Crawshaw, Jack Bailey, David Powell, Paul Connolly, Elizabeth Buchan, Valerie Grove, Adam Sherwin, Chrissie Hynde, Fiona Beckett, Robert Whymant, Penny Perrick, Sally Patten, Roland Watson Chief Political Correspondent, Douglas Kennedy, Meg Mathews, Patience Wheatcroft, Conal Urquart, Gillian Harris and Richard Ford, Grainne Gilmore, Roy Guy, Chloe Bryan-Brown, Susan Emmett, Richard Allen,
... Odeon The King and I: Gong Li in Chen Kaige's period… Bracknell Uci the Point 10 Brighton ...
2000 - Gale Group | TDA
Zu-Qi Zuo, Kaige Chen, Xiaoyuan Yu, Gui Zhao, Song Shen, Zhi‐Ting Cao, Ying‐Li Luo, Yucai Wang, Jun Wang,
Cancer stem cells (CSCs), which hold a high capacity for self-renewal, play a central role in the development, metastasis, and recurrence of various malignancies. CSCs must be eradicated to cure instances of cancer; however, because they can reside far from tumor vessels, they are not easily targeted by drug agents carried by nanoparticle-based drug delivery systems. We herein demonstrate that promoting tumor penetration of nanoparticles by transforming growth factor β (TGF-β) signaling pathway inhibition ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2015 - Elsevier BV | Biomaterials
Youcui Xu, Chang Yang, Yi Wu, Wei Jiang, Quan Cheng, Lifeng Yan, Kaige Chen, Yucai Wang,
Tumor metastasis remains the primary cause of treatment failure in cancer patients, and the high-sensitivity preoperative and intraoperative detection of occult micrometastases continues to pose a notorious challenge. Therefore, we have designed an in situ albumin-hitchhiking near-infrared window II (NIR-II) fluorescence probe, IR1080, for the precise detection of micrometastases and subsequent fluorescence image-guided surgery. IR1080 rapidly covalently conjugates with albumin in plasma, resulting ...
Tópico(s): Nanoparticle-Based Drug Delivery
2023 - American Chemical Society | Nano Letters
Yuantao Sun, Yingcheng Li, Qing Zhang, Xianrong Qin, Kaige Chen,
Tópico(s): Mechanical stress and fatigue analysis
2022 - Elsevier BV | Engineering Failure Analysis
Cheng‐Tao Jiang, Kaige Chen, An Liu, Hua Huang, Ya-Nan Fan, Dong‐Kun Zhao, Qian‐Ni Ye, Houbing Zhang, Cong‐Fei Xu, Song Shen, Menghua Xiong, Jin‐Zhi Du, Xianzhu Yang, Jun Wang,
Abstract Modulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T cells and tumor cells via chimeric antigen receptor- T cells or bispecific T cell-engaging antibodies are two typical cancer immunotherapy approaches. We speculated that immobilizing two types of mAbs against effector cells and tumor cells on a single nanoparticle could integrate the functions of these two approaches, as the engineered formulation (immunomodulating nano-adaptor, imNA) ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Nature Portfolio | Nature Communications
Lei Liu, Wen Xiong, Yanxin Liu, Kaige Chen, Zhong Xu, Yi Zhou, Han Jia, Cong Ye, Xin Chen, Zhitang Song, Min Zhu,
Abstract HfO 2 ‐based memristors that remembers the history of the current that has passed through them have attracted great interest for use as artificial synapses in neuromorphic systems. However, the low resistance contrast exhibited by HfO 2 ‐based memristors seriously decreases their recognition accuracy. By inserting a 2 nm BiFeO 3 layer a large memory window of 10 4 and remarkable pulse endurance of 10 8 cycles are achieved. Multilevel storage capability is also demonstrated by controlling ...
Tópico(s): Neuroscience and Neural Engineering
2020 - Wiley | Advanced Electronic Materials
Yuantao Sun, Lifu Luo, Kaige Chen, Xianrong Qin, Qing Zhang,
Based on the thought of Green’s kernel function method (GKFM), an improved time-domain load identification method using moving weighted least square technique (MWLST) which can accurately fit dynamic load is proposed. Better than the traditional shape function method using moving least square fitting (SFM_MLSF), the proposed method considers continuity and correlation of dynamic load between two adjacent sampling points, and involves the weighted contribution of sampling points to the fitting point. ...
Tópico(s): Advanced Adaptive Filtering Techniques
2020 - Elsevier BV | Computers & Structures
Cong‐Fei Xu, Zi-Dong Lu, Ying‐Li Luo, Yang Liu, Zhi‐Ting Cao, Song Shen, Hongjun Li, Jing Liu, Kaige Chen, Zhiyao Chen, Xianzhu Yang, Zhen Gu, Jun Wang,
The NLRP3 inflammasome is a well-studied target for the treatment of multiple inflammatory diseases, but how to promote the current therapeutics remains a large challenge. CRISPR/Cas9, as a gene editing tool, allows for direct ablation of NLRP3 at the genomic level. In this study, we screen an optimized cationic lipid-assisted nanoparticle (CLAN) to deliver Cas9 mRNA (mCas9) and guide RNA (gRNA) into macrophages. By using CLAN encapsulating mCas9 and gRNA-targeting NLRP3 (gNLRP3) (CLANmCas9/gNLRP3), ...
Tópico(s): Cholesterol and Lipid Metabolism
2018 - Nature Portfolio | Nature Communications
Song Shen, Yue Zhang, Kaige Chen, Ying‐Li Luo, Jun Wang,
Accumulating evidence has confirmed that malignant tumors have a complex microenvironment, which consists of a heterogeneous collection of tumor cells and other cell subsets (including the full gamut of immune cells). Tumor-associated macrophages (TAMs), derived from circulating Ly6Chi monocytes, constitute the most substantial fraction of tumor-infiltrating immune cells in nearly all cancer types and contribute to tumor progression, vascularization, metastasis, immunosuppression, and therapeutic ...
Tópico(s): Chemokine receptors and signaling
2018 - American Chemical Society | Molecular Pharmaceutics
Song Shen, Hongjun Li, Kaige Chen, Yucai Wang, Xianzhu Yang, Zhe‐Xiong Lian, Jin‐Zhi Du, Jun Wang,
Chemoimmunotherapy, which combines chemotherapeutics with immune-modulating agents, represents an appealing approach for improving cancer therapy. To optimize its therapeutic efficacy, differentially delivering multiple therapeutic drugs to target cells is desirable. Here we developed an immunostimulatory nanocarrier (denoted as BLZ-945SCNs/Pt) that could spatially target tumor-associated macrophages (TAMs) and tumor cells for cancer chemoimmunotherapy. BLZ-945SCNs/Pt undergo supersensitive structure ...
Tópico(s): Nanoparticle-Based Drug Delivery
2017 - American Chemical Society | Nano Letters
... 1991 Male Narcissism and National Culture: Subjectivity in Chen Kaige's King of the Children Rey Chow Rey ... Chow; Male Narcissism and National Culture: Subjectivity in Chen Kaige's King of the Children. Camera Obscura 1 ...
Tópico(s): Japanese History and Culture
1991 - Duke University Press | Camera Obscura Feminism Culture and Media Studies
Jianming Liu, Na Liu, Yuanyuan Yue, Yanyan Wang, Kaige Chen, Jia Zhang, Shufang Zhao, Kelei Zhuo,
The synthesis of chromeno[2,3-b]indole from simple starting materials remains a demanding process. Herein, 2-bromoindole undergoes nucleophilic attack from salicylaldehyde, followed by intramolecular insertion of an aldehyde group and aromatization to generate the desired chromeno[2,3-b]indoles. Moreover, various functional groups were tolerated and a gram-scale synthesis of the product could be achieved under the optimized condition.
Tópico(s): Catalytic C–H Functionalization Methods
2017 - Wiley | Chemistry - An Asian Journal
Kaige Chen, Ruoyu Chen, Hui Cang, Airong Mao, Zhe Tang, Qi Xu,
Ce/TiO2-SiO2 catalysts with different Ti/Si molar ratios are prepared by the incipient impregnation method and their NH3-SCR activities are evaluated at 100-500°C on a fixed reactor. The Ce/TiO2-SiO2 (3/1) catalyst, modified by non-thermal plasma (NTP) treatment and then activated by thermal treatment at 500°C for 4 h, exhibits best performance. Comprehensive deNOx performance of the catalyst is evidently improved and its efficiency reaches up to 99.21% at 350°C. NO conversion efficiency of the treated ...
Tópico(s): Catalysis and Oxidation Reactions
2017 - Taylor & Francis | Environmental Technology
Kaige Chen, Zheng Zhang, Ziyuan Fang, Jiachen Zhang, Qian Liu, Dong Wang, Yang Liu, Yucai Wang, Jun Wang,
Excessive infiltration of activated neutrophils is regarded as a predominant cause of tissue injury in neutrophilic inflammation. Although programmed cell death like apoptosis maintains the homeostasis of activated neutrophils, this process is disrupted by an abnormal inflammatory response. Unlike endogenous calreticulin exposed during apoptosis, exogenous calreticulin acts as an "aged" signal and initiates premature macrophage-mediated programmed cell removal (PrCR), which is independent of apoptosis. ...
Tópico(s): Immune cells in cancer
2023 - American Chemical Society | ACS Nano
Zaizhou Liu, Kaige Chen, Jun Dai, Peng Xu, Wei Sun, Wanlin Liu, Zhixin Zhao, Steven Bennett, Peifeng Li, Tiancheng Ma, Yuqi Lin, Akinori Kawakami, Jing Yu, Fei Wang, Handong Wang, Miao Li, Peter Chase, Peter Hodder, Timothy Spicer, Louis Scampavia, Chunyang Cao, Lifeng Pan, Jiajia Dong, Yong Chen, Biao Yu, Min Guo, Pengfei Fang, David E. Fisher, Jing Wang,
Tópico(s): RNA regulation and disease
2023 - Springer Nature | Cell Research
Kaige Chen, An Liu, Cheng‐Tao Jiang, Dong‐Kun Zhao, Qian‐Ni Ye, Yu‐Qi Liao, Cong‐Fei Xu, Song Shen, Jun Wang,
Innate immune cells, including natural killer cells and macrophages, are crucial in tumor surveillance and elimination. In contrast to the relatively complicated process of antigen-specific adaptive immunity, innate immune cells exhibit spontaneous tumoricidal effects by releasing cytolytic granules to adjacent tumor cells or by directly phagocytizing adjacent tumor cells. These effects of innate immune cells highlight the importance and necessity of spatial proximity between activated effector ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2021 - Elsevier BV | Nano Today
Kaige Chen, Song Shen, Gui Zhao, Zhi‐Ting Cao, Xianzhu Yang, Jun Wang,
Tópico(s): MicroRNA in disease regulation
2018 - Springer Science+Business Media | Nano Research
Qian Chen, Kaige Chen, Kun Wang, Jianfeng Ma, Haiyan Yang, Jinghuan Chen,
An attempt to correlate biomass characteristics to its susceptibility to enzymes is often inconclusive via investigation of the variables of hydrothermal pretreatment. Based on an integrated analysis of physicochemical properties, cellulose bioconversion, loss of pentose sugars, formation of inhibitory products, and the cost of energy, the optimal hydrothermal operation for wheat straw (1:20 w/v%) was found. This optimal operation involved cooling the hydrolysates as soon as the temperature reached ...
Tópico(s): Enzyme Catalysis and Immobilization
2018 - North Carolina State University | BioResources
... Beijing Film Academy (training ground for Zhang Yimou, Chen Kaige, and the of Chinese filmmakers who achieved international ... past of the famed fifth generation (Zhang Yimou, Chen Kaige, Tian Zhuangzhuang et al.), these younger filmmakers seek ...
Tópico(s): Hong Kong and Taiwan Politics
2003 - | Cineaction!
... or critics attack film directors Zhang Yimou and Chen Kaige whose successes in various international film festivals depend largely upon their being recognized by Western scholars and critics because their films are regarded as a version of Orientalism, or more exactly, as images made exclusively for a Western audience. 2 Meanwhile, overseas Chinese scholars view this attack on Zhang and Chen as a kind of Occidentalism. But to advocate ...
Tópico(s): Socioeconomic Development in Asia
1997 - Johns Hopkins University Press | New Literary History
Xiaolian Xiao, Lianlian Yu, Ziqing Dong, Ren Mbelek, Kaige Xu, Chen Lei, Wen Zhong, Feng Lu, Malcolm Xing,
A novel type of injectable hydrogel is demonstrated as a persistent filler and scaffold for effective repair of small facial depressed defects.
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2015 - Royal Society of Chemistry | Journal of Materials Chemistry B
Renjie Qiu, Xingying Zhang, Chen Song, Kaige Xu, Huijia Nong, Yi Li, Xianglong Xing, Kibret Mequanint, Qian Liu, Quan Yuan, Xiaomin Sun, Malcolm Xing, Leyu Wang,
Abstract Conductive cardiac patches can rebuild the electroactive microenvironment for the infarcted myocardium but their repair effects benefit by carried seed cells or drugs. The key to success is the effective integration of electrical stimulation with the microenvironment created by conductive cardiac patches. Besides, due to the concerns in a high re-admission ratio of heart patients, a remote medicine device will underpin the successful repair. Herein, we report a miniature self-powered biomimetic ...
Tópico(s): Muscle activation and electromyography studies
2024 - Nature Portfolio | Nature Communications