William N. Washburn, Mark C. Manfredi, Pratik Devasthale, Guohua Zhao, Saleem Ahmad, Andrés S. Hernández, Jeffrey A. Robl, Wei Wang, James Mignone, Zhenghua Wang, Khehyong Ngu, Mary Ann Pelleymounter, Daniel Angelo Longhi, Rui-Lin Zhao, Bei Wang, Ning Huang, Neil Flynn, Anthony V. Azzara, Joel C. Barrish, Kenneth W. Rohrbach, James J. Devenny, Suzanne Rooney, Michael A. Thomas, Susan Glick, Helen E. Godonis, Susan J. Harvey, Mary Jane Cullen, Hongwei Zhang, Christian Caporuscio, Paul Stetsko, Mary F. Grubb, Brad D. Maxwell, Hong Yang, Atsu Apedo, Brian Gemzik, Evan B. Janovitz, Christine Huang, Lisa Zhang, Chris Freeden, Brian J. Murphy,
Identification of MCHR1 antagonists with a preclinical safety profile to support clinical evaluation as antiobesity agents has been a challenge. Our finding that a basic moiety is not required for MCHR1 antagonists to achieve high affinity allowed us to explore structures less prone to off-target activities such as hERG inhibition. We report the SAR evolution of hydroxylated thienopyrimidinone ethers culminating in the identification of 27 (BMS-819881), which entered obesity clinical trials as the ...
Tópico(s): Pharmacology and Obesity Treatment
2014 - American Chemical Society | Journal of Medicinal Chemistry
Xiang‐Yang Ye, Christian L. Morales, Ying Wang, Karen A. Rossi, Sarah E. Malmstrom, Mojgan Abousleiman, Larisa Sereda, Atsu Apedo, Jeffrey A. Robl, Keith J. Miller, John Krupinski, Dean A. Wacker,
Through appropriate medicinal chemistry design tactics and computer-assisted conformational modeling, the initial lead A was evolved into a series of dihydrobenzofuran derivatives 3 as potent GPR119 agonists. This Letter describes the optimization of general structure 3, including the substituent(s) on dihydrobenzofuran, the R(1) attachment on right-hand piperidine nitrogen, and the left-hand piperidine/piperazine and its attachment R(2). The efforts led to the identification of compounds 13c and ...
Tópico(s): Neuropeptides and Animal Physiology
2014 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Jibira Yakubu, George Asumeng Koffuor, Talent Atsu-Nunyawu, Jeremiah Aboagye, Irene Aasam Aabeinir, Fasilatu Alhassan, Lord Christian Ocran, Philomena Entsie,
To establish the wound management property of a hydroethanolic Cnestis ferruginea leaf extract (CFHE).The wound area was measured after excision at the dorsal part of the Albino rats, and after treatment with 5-15% w/w CFHE ointments for 14 days. Absorbances of platelet-rich plasma treated with 0.8-100 mg/mL CFHE and an aggregating agent were spectrophotometrically determined in an in vitro platelet aggregation test. Wound tissue histopathology of CFHE ointment-treated animals revealed angiogenesis, ...
Tópico(s): Tendon Structure and Treatment
2021 - Hindawi Publishing Corporation | Advances in Pharmacological and Pharmaceutical Sciences
Koichi Ojima, Yukiko Kawabata, Harumi Nakao, Kazuki Nakao, Naoko Doi, Fujiko Kitamura, Yasuko Ono, Shoji Hata, Hidenori Suzuki, Hiroyuki Kawahara, Julius Bogomolovas, Christian Witt, Coen A. C. Ottenheijm, Siegfried Labeit, Henk Granzier, Noriko Toyama‐Sorimachi, Michiko Sorimachi, Koichi Suzuki, Tatsuya Maeda, Keiko Abe, Atsu Aiba, Hiroyuki Sorimachi,
Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease that is caused by mutations in the calpain 3 gene (CAPN3), which encodes the skeletal muscle-specific calpain, calpain 3 (also known as p94). However, the precise mechanism by which p94 functions in the pathogenesis of this disease remains unclear. Here, using p94 knockin mice (termed herein p94KI mice) in which endogenous p94 was replaced with a proteolytically inactive but structurally intact p94:C129S mutant protein, we have demonstrated ...
Tópico(s): Adipose Tissue and Metabolism
2010 - American Society for Clinical Investigation | Journal of Clinical Investigation
Benedicta Kafui Atsu, Chris Guure, Amos Laar,
... CI, 1.003–1.017). Compared to religious (Christians/Muslim/Traditionalist) household heads, children whose household heads ...
Tópico(s): Food Security and Health in Diverse Populations
2017 - BioMed Central | BMC Pediatrics
... doi.org/10.1007/s41480-012-0024-0J. Atsu Amegashie, Marco Runkel The Paradox of Revenge in ...
Tópico(s): Resilience and Mental Health
1990 - University of Chicago Press | Ethics
Charles Y.C. Pak, Cindy J. Fuller, Khashayar Sakhaee, Joseph E. Zerwekh, Beverley V. Adams,
... date: 1-Jan-2003.TEKIN A, TEKGUL S, ATSU N, SAHIN A and BAKKALOGLU M (2018) CYSTINE ...
Tópico(s): Urinary Bladder and Prostate Research
1986 - Lippincott Williams & Wilkins | The Journal of Urology
Denis H. Hosking, Stephen B. Erickson, C. J. Van Den Berg, David M. Wilson, Lynwood H. Smith,
... date: 1-Mar-2003.TEKIN A, TEKGUL S, ATSU N, BAKKALOGLU M and KENDI S (2018) Oral ...
Tópico(s): Porphyrin Metabolism and Disorders
1983 - Lippincott Williams & Wilkins | The Journal of Urology
John Christian Ehlen, Daniela Ostrowski, Tim D. Ostrowski,
... hypotension in AD patients. Support or Funding Information ATSU biomedical grant (JCE) and seed money (TDO) This ...
Tópico(s): Stress Responses and Cortisol
2019 - Wiley | The FASEB Journal
Julien Allard, David Albala, Justin M. Albani, Peter Albers, Lumina S. Albert, Peter J. Albert, Donna Albertson, Michael Albo, Sotirios Athanasiadis, Necmettin Atsu, Erik Attia, Jean-Pierre Aubert, Sébastien Aubert, Brian K. Auge, Homero Oliveira de Arruda, Raffaella Artusi, Manit Arya, Nobuaki Asai, Junichi Asakuma, Harunobu Asano, Koji Asano, Takako Asano, Albair Ashamallah, Peter Ashijian, Katsuhiro Ashitomi, John Ashworth, Guven Asian, G Assimos, Rebecca S. Arnold, William J. Aronson, Herbert Augustin, Titus Augustine, Joanna M. Austin, Riccardo Autorino, Robert Avenson, Mandy Avis, Avolio Luigi, Alberto Ayala, Gustavo Ayala, Aybek Zafer, Ibrahim Aydogdu, Haruhito Azuma, Azuma Hiroshi, Abdel Rahmène Azzouzi, Eun Ji Bae, Richard K. Babayan, Marcio Babinski, Romeo Bachand, Ketan K. Badani, Shiro Badlani, Richard J. Babaian, A Arnautovic, Indira Arnautovic, Theodore Anagnostou, Jason Anast, Aristotelis G. Anastasiadis, Chris Anderson, David Anderson, Kyle Anderson, Dale Ando, Cristian Andrade, Enrico Andrade, Cássio Andreoni, Ben Andrews, Daniela E. Andrich, Javier Angulo, Brian H. Annex, Ian Antenor, Jo Ann, Gaby Anthonijs, Patrick V, Alessia Antonelli, Antonia Scott, Artur A. Antoniewicz, Ramani Anup, Veronica Anwuri, Rodney A. Appell, Linda D. Applegarth, Olga Aprelikova, Armen Aprikian, Yasuyuki Arai, Yoichi Arai, Yoshitaka Arakaki, Isao Araki, Marco A. Arap, Ryoji Arata, Gianluigi Ardissino, David Arend, Joseph C. Arezzo, Philip M. Arlen, Abdullah Armağan, Noel A. Armenakas, Josep Alcoberro, Joel Aldana, Alessandro Zucchi, Johnny Alexander, Richard Alexander, Alexandre Laurent, Gary Alexis, Wladimir Alfer, Zeni Alfonso, Amina Ali, Najeeba Ali, Yurij Aliaev, Rosalinda Allegro, Wade G. Alleman, E. P. Allhoff, Alphonse Paul, Alex Althausen, Stanley E. Althof, Vincenzo Altieri, Jens-Erik Altwein, Stefan Altziebler, Alvarez De Mon, Yoshihiro Amiel, A. Akdaş, Bülent Akdoğan, Fatma Aktepe, Mohammad Ai-Omar, Tahseem Al-Saleern, T Ai-Tiraihi, Noori Ai-Waili, Hassan Ai-Zahrani, Martti Ala-Opas, Zeynep Alademir, Gustavo Alarcon, Peeter Alas, Seyed-Sadegh Alavi, Maryam Aalamian, Ravikumar Aalinkeel, José Gutiérrez Abascal, Clément‐Claude Abbou, Khaled, Gaber Abdel-Latif, M Ped- Abdelhady, Mazen, Joseph Abdelmalak, Jose Aboin, Hassan Abol-Enein, Sherif R. Aboseif, Abou, Hassan El-Enin, Harrison M. Abrahams, Neil A. Abrahams, Paul Abrams, Sidney C. Abreu, R. Ackermann, Pietro Acquati, Rosalyn Adam, Hans‐Olov Adami, Judith E. Adams, Michael Adams, K. Addicks, Mohamed Adel, Gregory Adey, Jan Adolfsson, Luciano Adorini, Hakon Ageheim, Aditya K. Agrawal, Chiledum Ahaghotu, Thomas E. Ahlering, Ahmed Ahmed, Ok Ahn, Jun Gook, Hanjong Ahn, Kwang-Sung Ahn, Tai Ahn, Steven Ahrendt, Sanjeev Ahuja, Junkui Ai, Ken Aikawa, Karen Aitken, Teruaki Akaeda, Koichiro Akakura, Akbari Asbagh, Firooze Akbari, Majid Akcay, Tulay Bansard, Yves Jean, Menashe Yongd E Bar-Eli, Chri Bangma, H Baniel, Jack Bank, A. Leslie Banks, Fredd Ie Bank, Kevin Bank, Roz Banne, Marc Bansal, Adity Haim, Erez Bar-Meir, Elisha Cascante, Antonio Barata, Henrique Barb, G. Barber, Neil Barbero, G. Barbieri, Luigi Bardari, Franco Barell, Luca Bargm, Vladislav Barnas, Jennifer Barnes, Robert C. Baron, Colin Barroso, Ubirajara Bartel, Frank Bartenstein, Peter Barth, Josef Barth, Peter Behrend, Christian Beiko, Darren Beisland, Chri Stian Bernabe, Alexander Berndt, Dan Berney, Roos Bernsen, Donna Bernstein, Philippe Berthon, Bert Ini Roberto, Bert Oldin, Bert Olla, Carolyn Betts, Saverio Bettuzzi, Axel Bex, Sam B. Bhayani, Russell Bialecki, Angejo Bianco, Fern Bianco, Roberta Bichi, Roy Bicknell, Diane Bielsky, Richard Stephen Bihrl E, Vladimir Bilim, Hector Biliran, Bill Axelson, Marcia Billings, Kevin L. Billups, Brian Birch, Vincent G. Bird, Lori A. Birder, John Bischof, Erwin Bischoff, Peter Bishai, I Dn, Jay T. Bishoff, Thoma Bjork, Dale Bjorling, M. Glen Black, Peter M. Black, Blackmore Peter, Catherine Blackwell, Jerry G. Blaivas, K L Blanchard, Salvatore Blanco, Marco H. Blanker, John Blasko, Sharon Bledsoe, David S. Berman, Jennifer R. Berman, Laura Berman, Carlos E. Bermejo, Hans Beisland, Bayu Begashaw Bekele, Bektic Nebi, Bradley Bell, Henry Bell, Bella Anthon, Belle Andrew, Piero Belmonte, Mandi Beman, Debra Bemis, Ben Naoum, Benedi Ct, Carol Bennett, John M. Bennett, Nelson Bennett, Susan Benoff, Gerard Beno It, Ben Sadoun, Karim Bensalah, Christ Ina M Bentley, James Benton, Brian Benw Ay, Eliana Beraldi, Beren Guer, Kate Berg, Nicole Berger, Elizabeth Bergert, Sven Bergh, Martin Bergmann, Margo Canto, Alan Cantor, Guangwen Cao, Paola Capodieci, Andrea Caporali, Joseph C. Cappelleri, Jorg Caprano, Joaquı́n Carballido,
Lippincott Williams & Wilkins
Robert D. Abbott, Chris Abell, Aiba Atsu, Beatriz Álvarez, Richard Austin, B Bagi, Mark Baker, Heinrich Betz, David Bode, Bräuner-Osborne Hans, Donald A. Bryant, Clive Thomas Cain, Myles Cheesman, Stephen J. Wayne, Steven K. Cheng, Jude Chenge, Coitin ̃o, E Laura, Anthony G. Coyne, D De Greef, Del Piccolo, Tara Dillon, Yue-He Ding, Lê Văn Duyệt, Fernando Faccio, Bryan Ferlez, G Girault, Hazel M. Girvan, Anette Prior, John H. Golbeck, Niels Grarup, D. Gutmann, Hidetoshi Hamada, Henri Theil, Simin He, Natalie Hendrikse, Joachim Herz, Christian Holt, Robert Hromas, I Inoue, Jeroen J.W.M. Janssen, L Dan, Jørgensen Stine, Jun Wang, Jusu Sylvester, Kayranto Kasho, Madeline E. Kavanagh, Michael T. Kemp, Hyun-Suk Kim, L Labuda, K.T. Larsen, Suk-Hee Lee, Colin Levy, Allan Linneberg, Lopez-Pastraña Jahaira, M Ma, Evan Mallette, Miriam Matamales, Kirsty J. McLean, Haley Melikian, Mo ̈ller, Rainer Mueller, Andrew W. Munro, Veronica Musante, N Na, Angus C. Nairn, Jac A. Nickoloff, O Ohta, Michael T. Overgaard, Panos Papadopoulos, Andrew Pascal, Pascal A. Pieters, John Presley,
2017 - Elsevier BV | Journal of Biological Chemistry