Andrew Robson, Graham Yeoman, Simon Barnes Chief Sports Writer, Raymond Snoddy Media Editor, Helen Studd, Robert Cole, Andrew Pierce, Jess Clynewood, Adam Sherwin Media Reporter, Sarah Potter, Frances Gibb Legal Editor, Gary Duncan, Simon Barnes, Stuart Crainer People and Profit, Magnus Linklater, Peter Lansley, Philip McMullen, Osman Streater, Richard Power, Mark Souster, Mark Frary, Richard Hobson, Anthony Seaton, Ken Coates (Chairman), Ivo Tennant, Philip Webster, Stewart Tendler and Richard Ford, Brian Porter, Michael Evans Defence Editor, David Chater, James Bone, Nic Hopkins, Richard Hallward, Alison Kervin, Graham Zellick, Roland Watson and Elaine Monaghan and Nicholas Blanford, Sheila Johnston, Ron Holley, Brian Barder, Gabrielle Starkey, Richard Eaton, Barbara Ellen, Patrick Barkham, Jerry Green, John Read, Amon Cohen, Raymond Snoddy, Joe Joseph, Andrew Norfolk, Ben Webster Transport Correspondent, Helen Nugent and Jenny Davey, Malcolm Ginsberg, Pat Gibson, Jeremy Hazelhurst, Mark Court and Antonia Senior, Tina Brown, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Anthony Browne, Dominic Walsh, Charlie Flindt, Peter Watson, Geoffrey Dean in Harare, Daniel Finkelstein, Dalya Alberge Arts Correspondent, Phoebe Greenwood, Richard Ford Home Correspondent, Martin Montville, Alan Hamilton, Gerald Ratzin, Nick Wyke, Anatole Kaletsky, Mark Ellen, Matt Dickinson Chief Football Correspondent, Norman Hammond Archaeology Correspondent, Mark Court, Caroline Merrell Banking Correspondent, Richard Falconer, Hugo Rifkind, Tom Baldwin, Ben Hoyle and Ruth Gledhill, Andrew Ratcliffe Finance & Accountancy Viewpoint, Russell Kempson, Chris Doyle (Director), Tony Halpin Education Editor, Martha Goyder, Marc Beckers, Mark Preiss, Oliver Kay, Sarah Vine, Nicky Gill, Mark Henderson Science Correspondent, Michael Varcoe-Cocks, Christopher Martin-Jenkins, Simon de Bruxelles, John Hopkins Golf Correspondent, Oliver Wright and Anthony Browne, Elaine Monaghan, Desmond Julian, Raymond Keene, Sean MacAulay, Matt Dickinson, Philip Whiteley, Christine Buckley Industrial Editor, Ruth Gledhill and Richard Miles, John Cooney, John Peck, Lesley Hulley, Greg Hurst Parliamentary Correspondent, Beryl Dixon, Jenny Davey and Helen Nugent, Chris Campling, Russell Hotten, Kate Rew, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, David Mattin, David Charter and Roger Maynard, Emily Davies, O. A. Denly, Nick Hasell, Peter Dixon, Updesh Kapur, David Hands Rugby Correspondent, John Allison, John Goodbody, James Doran, Melissa Kite Political Correspondent, Philip Webster Political Editor, Christopher Walker, Tony Smythe, Mel Webb, Ian Johns, Dan Sabbagh Analysis, Allan Solomon, Catherine Philp South Asia Correspondent, Chris McGrath, George Caulkin, Lea Paterson and Gary Duncan, Ingrid Mansell, Peter Riddell, Ben MacIntyre, Lea Paterson Economics Editor, Tony Dawe, Ben Webster, Richard Beeston Diplomatic Editor, Graham Cleverley, Jack Malvern Arts Reporter, David Sinclair, Gary Duncan Economics Correspondent, Catherine Philp, Martin Waller, Michael Horsnell, Chris Ayres, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Melissa Kite and Greg Hurst, Dr Thomas Stuttaford, Stephen Dalton, Roy Farrar, Tom Chesshyre, Matthew Connolly, Emily Davies Fashion Writer, Owen Slot, Jenny Davey, Edward Gorman Sailing Correspondent, Colin McQuillan, Patience Wheatcroft, Janine di Giovanni, Christopher Irvine, David Lister Ireland Correspondent,
... Zebra KO Ecs Eligo recruitment Career Energy Avery Berkel Oxford We Urgently Require Business Development Managers Jobsearchers. ...
2003 - Gale Group | TDA
Uwe Schneidewind, M. van Berkel, Christian Anibas, Gerd Vandersteen, Christian Schmidt, Ingeborg Joris, Piet Seuntjens, Okke Batelaan, Hans Zwart,
Abstract We introduce LPMLE3, a new 1‐D approach to quantify vertical water flow components at streambeds using temperature data collected in different depths. LPMLE3 solves the partial differential equation for coupled water flow and heat transport in the frequency domain. Unlike other 1‐D approaches it does not assume a semi‐infinite halfspace with the location of the lower boundary condition approaching infinity. Instead, it uses local upper and lower boundary conditions. As such, the streambed ...
Tópico(s): Groundwater flow and contamination studies
2016 - Wiley | Water Resources Research
Laura Van Berkel, Christian S. Crandall, Scott Eidelman, John C. Blanchar,
Hierarchy and dominance are ubiquitous. Because social hierarchy is early learned and highly rehearsed, the value of hierarchy enjoys relative ease over competing egalitarian values. In six studies, we interfere with deliberate thinking and measure endorsement of hierarchy and egalitarianism. In Study 1, bar patrons' blood alcohol content was correlated with hierarchy preference. In Study 2, cognitive load increased the authority/hierarchy moral foundation. In Study 3, low-effort thought instructions ...
Tópico(s): Psychology of Moral and Emotional Judgment
2015 - SAGE Publishing | Personality and Social Psychology Bulletin
Benjamin Berkels, Christian H. Liebscher,
Aberration corrected scanning transmission electron microscopes (STEM) enable to determine local strain fields, composition and bonding states at atomic resolution. The precision to locate atomic columns is often obstructed by scan artifacts limiting the quantitative interpretation of STEM datasets. Here, a novel bias-corrected non-rigid registration approach is presented that compensates for fast and slow scan artifacts in STEM image series. The bias-correction is responsible for the correction ...
Tópico(s): Force Microscopy Techniques and Applications
2018 - Elsevier BV | Ultramicroscopy
Simone Berkel, Christian R. Marshall, Birgit Weiß, Jennifer Howe, Ralph Roeth, Ute Moog, Volker Endris, Wendy Roberts, Peter Szatmari, Dalila Pinto, Michael Bonin, Angelika Rieß, Hartmut Engels, Rolf Sprengel, Stephen W. Scherer, Gudrun Rappold,
Tópico(s): Genetics and Neurodevelopmental Disorders
2010 - Nature Portfolio | Nature Genetics
Daoguang Yan, Matti Jauhiainen, Reeni B. Hildebrand, Ko Willems van Dijk, Theo J.C. van Berkel, Christian Ehnholm, Miranda Van Eck, Vesa M. Olkkonen,
Objective— The purpose of this study was to assess the role of macrophage OSBP-related protein 1L (ORP1L) in the development of atherosclerosis. Methods and Results— C57BL/6 mice overexpressing human ORP1L in macrophages driven by scavenger receptor A promoter were generated. Bone marrow (BM) of the mice was transplanted into LDLr −/− animals, and aortic root lesion area in the recipients was determined after Western-type diet feeding. The recipients of ORP1L BM displayed 2.1-fold increase ( P <0.001) in ...
Tópico(s): Lipid metabolism and biosynthesis
2007 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Ilze Bot, Saskia C.A. de Jager, Alma Zernecke, Ken A. Lindstedt, Theo J.C. van Berkel, Christian Weber, Erik A.L. Biessen,
Background— Mast cells are major effector cells in allergy and host defense responses. Their increased number and state of activation in perivascular tissue during atherosclerosis may point to a role in cardiovascular disorders. In the present study, we investigated the contribution of perivascular mast cells to atherogenesis and plaque stability in apolipoprotein E–deficient mice. Methods and Results— We show here that episodes of systemic mast cell activation during plaque progression in mice ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2007 - Lippincott Williams & Wilkins | Circulation
Riikka Vikstedt, Dan Ye, Jari Metso, Reeni B. Hildebrand, Theo J.C. van Berkel, Christian Ehnholm, Matti Jauhiainen, Miranda Van Eck,
Systemic phospholipid transfer protein (PLTP) deficiency in mice is associated with a decreased susceptibility to atherosclerosis, whereas overexpression of human PLTP in mice increases atherosclerotic lesion development. PLTP is also expressed by macrophage-derived foam cells in human atherosclerotic lesions, but the exact role of macrophage PLTP in atherosclerosis is unknown.To clarify the role of macrophage PLTP in atherogenesis, PLTP was selectively disrupted in hematopoietic cells, including ...
Tópico(s): Lipid metabolism and biosynthesis
2006 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Hanna Berkel, Christian Estmann, John Rand,
In sub-Saharan Africa, many micro and small enterprises do not (or at least only partially) comply with official rules and regulations. Given that low compliance rates impede economic growth and human development, it is essential to identify mechanisms that can help improve abidance with laws. This paper investigates how the quality of governance (defined as comprising three dimensions: transparency, legal security and infrastructure quality) is related to firm-level compliance with business laws ...
Tópico(s): Regulation and Compliance Studies
2022 - Elsevier BV | World Development
Markus Lucerna, Alma Zernecke, R. de Nooijer, Saskia C.A. de Jager, Ilze Bot, Christian van der Lans, Ivana Kholová, Elisa A. Liehn, Theo J.C. van Berkel, Seppo Ylä‐Herttuala, Christian Weber, E.A.L. Biessen,
Abstract Vascular endothelial growth factor-A is widely used in clinical trials for the treatment of cardiac ischemia. VEGF-A was recently suggested to act in a proinflammatory manner, which could aggravate adjacent atherogenesis in VEGF-A–based therapy. To assess potential bystander effects, VEGF-A was focally overexpressed in advanced atherosclerotic plaques in ApoE−/− mice. Sheer-induced carotid artery plaques were transluminally incubated with Ad.hVEGF-A leading to neointimal overexpression ...
Tópico(s): Protease and Inhibitor Mechanisms
2006 - Elsevier BV | Blood
Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro dell' Aglio, Darius Juškevičius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C. Wellinger, Ian Kirby, Patrick H. van Berkel, Christian Künz, Jérôme Tamburini, Francesco Bertoni, Corinne C. Widmer, Shengdar Q. Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T. Jeker,
Abstract Haematopoietic stem cell (HSC) transplantation (HSCT) is the only curative treatment for a broad range of haematological malignancies, but the standard of care relies on untargeted chemotherapies and limited possibilities to treat malignant cells after HSCT without affecting the transplanted healthy cells 1 . Antigen-specific cell-depleting therapies hold the promise of much more targeted elimination of diseased cells, as witnessed in the past decade by the revolution of clinical practice for ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2024 - Nature Portfolio | Nature
Yuan Yu, Chongjian Zhou, Xiangzhao Zhang, Lamya Abdellaoui, Christian Doberstein, Benjamin Berkels, Bangzhi Ge, Guanjun Qiao, Christina Scheu, Matthias Wuttig, Oana Cojocaru‐Mirédin, Siyuan Zhang,
High thermoelectric energy conversion efficiency requires a large figure-of-merit, zT, over a broad temperature range. To achieve this, we optimize the carrier concentrations of n-type PbTe from room up to hot-end temperatures by co-doping Bi and Ag. Bi is an efficient n-type dopant in PbTe, often leading to excessive carrier concentration at room temperature. As revealed by density functional theory calculations, the formation of Bi and Ag defect complexes is exploited to optimize the room temperature ...
Tópico(s): Advanced Thermodynamics and Statistical Mechanics
2022 - Elsevier BV | Nano Energy
Dirk Gründemann, Christian Hahne, Reinhard Berkels, Edgar Schömig,
Agmatine has received considerable attention recently. Available evidence suggests that agmatine functions as a neurotransmitter and inhibits, via induction of antizyme, cellular proliferation. Because of its positive charge, agmatine will not appreciably cross cellular membranes by simple diffusion. Indeed, all physiological models require a channel or transporter protein in the plasma membrane to effect inactivation or nonexocytotic release of agmatine. However, a transport mechanism for agmatine ...
Tópico(s): Neuroscience and Neuropharmacology Research
2003 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Kees van Berkel, Christian Straßer,
Normative reasoning is inherently defeasible. Formal argumentation has proven to be a unifying framework for representing nonmonotonic logics. In this work, we provide an argumentative characterization of a large class of Input/Output logics, a prominent defeasible formalism for normative reasoning. In many normative reasoning contexts, one is not merely interested in knowing whether a specific obligation holds, but also in why it holds despite other norms to the contrary. We propose sequent-style ...
Tópico(s): Semantic Web and Ontologies
2022 - | Frontiers in artificial intelligence and applications
2008 - Springer VS | Publizistik
Johannes Hermes, Derek Van Berkel, Benjamin Burkhard, Tobías Plieninger, Nora Fagerholm, Christina von Haaren, Christian Albert,
Recreational ecosystem services (RES), understood as the numerous benefits people obtain from landscapes and the natural environment, are a topical area of policy, research and society. This Editorial introduces the current state of RES research, provides an overview of the 21 contributions comprising this Special Issue of Ecosystem Services, and outlines opportunities for further research. This issue's publications employ diverse methods for assessing and valuing RES at different scales in Europe ...
Tópico(s): Conservation, Biodiversity, and Resource Management
2018 - Elsevier BV | Ecosystem Services
Selin Kara, Dominik Spickermann, Joerg H. Schrittwieser, Christian Leggewie, Willem J. H. van Berkel, Isabel W. C. E. Arends, Frank Hollmann,
1,4-Butanediol is shown to be an efficient cosubstrate to promote NAD(P)H-dependent redox biocatalysis. The thermodynamically and kinetically inert lactone coproduct makes the regeneration reaction irreversible. Thereby not only the molar surplus of cosubstrate is dramatically reduced but also faster reaction rates are obtained.
Tópico(s): Carbon dioxide utilization in catalysis
2012 - Royal Society of Chemistry | Green Chemistry
Saskia C.A. de Jager, Beatriz Bermúdez, Ilze Bot, Rory R. Koenen, Martine Bot, Annemieke Kavelaars, Vivian de Waard, Cobi J. Heijnen, Francisco J.G. Muriana, Christian Weber, Theo J.C. van Berkel, Johan Kuiper, Se‐Jin Lee, Rocı́o Abia, Erik A.L. Biessen,
Growth differentiation factor (GDF) 15 is a member of the transforming growth factor β (TGF-β) superfamily, which operates in acute phase responses through a currently unknown receptor. Elevated GDF-15 serum levels were recently identified as a risk factor for acute coronary syndromes. We show that GDF-15 expression is up-regulated as disease progresses in murine atherosclerosis and primarily colocalizes with plaque macrophages. Hematopoietic GDF-15 deficiency in low density lipoprotein receptor−/− ...
Tópico(s): Nuclear Receptors and Signaling
2011 - Rockefeller University Press | The Journal of Experimental Medicine
Wendy P. J. den Elzen, Christa M. Cobbaert, Jacqueline M. T. Klein Gunnewiek, Dirk L. Bakkeren, Miranda van Berkel, Marieke A. M. Frasa, Robert Herpers, Aldy W.H.M. Kuypers, Christian Ramakers, Roseri J.A.C. Roelofsen-de Beer, Hans van der Vuurst, Cas Weykamp,
Tópico(s): Erythropoietin and Anemia Treatment
2018 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Slavil Peykov, Simone Berkel, Michael Schoen, Kerstin Weiß, Franziska Degenhardt, Jana Strohmaier, B Weiss, Christian Proepper, Gerhard Schratt, Markus M. Nöthen, Tobias M. Boeckers, Marcella Rietschel, Gudrun Rappold,
Recent genetic data on schizophrenia (SCZ) have suggested that proteins of the postsynaptic density of excitatory synapses have a role in its etiology. Mutations in the three SHANK genes encoding for postsynaptic scaffolding proteins have been shown to represent risk factors for autism spectrum disorders and other neurodevelopmental disorders. To address if SHANK2 variants are associated with SCZ, we sequenced SHANK2 in 481 patients and 659 unaffected individuals. We identified a significant increase ...
Tópico(s): Genomics and Rare Diseases
2015 - Springer Nature | Molecular Psychiatry
Peng Ma, Hendrik Nicolai, Qian Huang, Paulo Debiagi, Leon Loni Berkel, Alessandro Stagni, Yuanping Yang, Christian Hasse, Shuiqing Li,
Co-firing ammonia with coal is a promising and feasible technology for reducing coal-related carbon emissions. Pyrolysis and ignition of ammonia-coal blended fuels are the key steps for flame stability and boiler operation safety throughout the conversion process but remain unclear. In this work, an extended Euler–Lagrange framework coupled to detailed solid-phase pyrolysis kinetics and gas-phase reactions mechanism is introduced and validated against experimental results for ammonia-coal co-firing ...
Tópico(s): Advanced Combustion Engine Technologies
2024 - Elsevier BV | Combustion and Flame
Christian V. Hulzebos, Johanna E Camara, Miranda van Berkel, Vincent Delatour, Stanley F. Lo, Agnès Mailloux, Marcel C. Schmidt, Mercy Thomas, Lindsey G. Mackay, Ronda F. Greaves,
Abstract Measurement of total bilirubin (TBil) concentration in serum is the gold standard approach for diagnosing neonatal unconjugated hyperbilirubinemia. It is of utmost importance that the measured TBil concentration is sufficiently accurate to prevent under treatment, unnecessary escalation of care, or overtreatment. However, it is widely recognized that TBil measurements urgently require improvement in neonatal clinical chemistry. External quality assessment (EQA) programs for TBil assess for ...
Tópico(s): Hemoglobinopathies and Related Disorders
2024 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
David Holmes, David M. Pettigrew, Christian H. Reccius, James D. Gwyer, C. van Berkel, Judith A. Holloway, Donna E. Davies, Hywel Morgan,
Miniature high speed label-free cell analysis systems have yet to be developed, but have the potential to deliver fast, inexpensive and simple full blood cell analysis systems that could be used routinely in clinical practice. We demonstrate a microfluidic single cell impedance cytometer that performs a white blood cell differential count. The device consists of a microfluidic chip with micro-electrodes that measure the impedance of single cells at two frequencies. Human blood, treated with saponin/ ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2009 - Royal Society of Chemistry | Lab on a Chip
Miranda Van Eck, Dan Ye, Reeni B. Hildebrand, J. Kar Kruijt, Willeke de Haan, Menno Hoekstra, Patrick C.N. Rensen, Christian Ehnholm, Matti Jauhiainen, Theo J.C. van Berkel,
Abundant amounts of cholesteryl ester transfer protein (CETP) are found in macrophage-derived foam cells in the arterial wall, but its function in atherogenesis is unknown. To investigate the role of macrophage CETP in atherosclerosis, LDL receptor knockout mice were transplanted with bone marrow from CETP transgenic mice, which express the human CETP transgene under control of its natural promoter and major regulatory elements. CETP production by bone marrow-derived cells induced a 1.8-fold ( P <0. ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2007 - Lippincott Williams & Wilkins | Circulation Research
Ilze Bot, Isabelle Daissormont, Alma Zernecke, Gijs H.M. van Puijvelde, Birgit K. Kramp, Saskia C.A. de Jager, Judith C. Sluimer, Marco Manca, Veronica Hérias, Marijke M. Westra, Martine Bot, Peter J. van Santbrink, Theo J.C. van Berkel, Lishan Su, Mona Skjelland, Lars Gullestad, Johan Kuiper, Bente Halvorsen, P. Aukrust, Rory R. Koenen, Christian Weber, Erik A.L. Biessen,
Aims The SDF-1α/CXCR4 dyad was previously shown by us and others to be instrumental in intimal hyperplasia as well as early stage atherosclerosis. We here sought to investigate its impact on clinically relevant stages of atherosclerosis in mouse and man. Methods and results Immunohistochemical analysis of CXCR4 expression in human atherosclerotic lesions revealed a progressive accumulation of CXCR4+ cells during plaque progression. To address causal involvement of CXCR4 in advanced stages of atherosclerosis ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2014 - Elsevier BV | Journal of Molecular and Cellular Cardiology
Leon Loni Berkel, Paulo Debiagi, Hendrik Nicolai, Muhammad Ahsan Amjed, Alessandro Stagni, Christian Hasse, Tiziano Faravelli,
In the near future, biomass is expected to be a key resource for fulfilling clean energy requirements. The predictive modeling of biomass conversion in industrial systems is still challenging due to the multi-scale nature of the processes involved, including complex chemical reactions. To provide a detailed description and analysis of these reactions and their coupling to transport phenomena in large-scale systems, this work introduces a multiphase reactor network method incorporating efficient ...
Tópico(s): Biofuel production and bioconversion
2023 - Elsevier BV | Fuel
Indira Medina, Céline Cougoule, Maik Drechsler, Beatriz Bermúdez, Rory R. Koenen, Judith C. Sluimer, Ine M. J. Wolfs, Yvonne Döring, Veronica Hérias, Marjon Gijbels, Ilze Bot, Saskia C.A. de Jager, Christian Weber, Jack P.M. Cleutjens, Theo J.C. van Berkel, Kees-Jan Sikkink, Atilla Mócsai, Isabelle Maridonneau‐Parini, Oliver Soehnlein, Erik A.L. Biessen,
Leukocyte migration is critical for the infiltration of monocytes and accumulation of monocyte-derived macrophages in inflammation. Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability was evaluated.
Tópico(s): Platelet Disorders and Treatments
2015 - Lippincott Williams & Wilkins | Circulation
Christian H. Liebscher, Mengji Yao, Poulumi Dey, Marta Lipińska-Chwałek, Benjamin Berkels, Baptiste Gault, Tilmann Hickel, Michael Herbig, Joachim Mayer, Jörg Neugebauer, Dierk Raabe, Gerhard Dehm, Christina Scheu,
Correlative scanning transmission electron microscopy, atom probe tomography, and density functional theory calculations resolve the correlation between elastic strain fields and local impurity concentrations on the atomic scale. The correlative approach is applied to coherent interfaces in a $\ensuremath{\kappa}$-carbide strengthened low-density steel and establishes a tetragonal distortion of fcc-Fe. An interfacial roughness of $\ensuremath{\sim}1\phantom{\rule{4pt}{0ex}}\mathrm{nm}$ and a localized ...
Tópico(s): Metal and Thin Film Mechanics
2018 - American Physical Society | Physical Review Materials
Éric Baudin, B. Goichot, Alfredo Berruti, Julien Hadoux, Salma Moalla, Sandrine Laboureau, Svenja Nölting, Christelle de la Fouchardière, Tina Kienitz, Timo Deutschbein, Stefania Zovato, Laurence Amar, Magalie Haissaguerre, Henri Timmers, Patricia Niccoli, Antongiulio Faggiano, M. Angokai, Livia Lamartina, Florina Luca, Deborah Cosentini, Stefanie Hahner, Felix Beuschlein, Marie Attard, Matthieu Texier, Martin Faßnacht, Christine Do Cao, Delphine Drui, Françoise Borson‐Chazot, Olivier Chabre, Delphine Vezzosi, Frédéric Castinetti, Jérôme Bertherat, Rossella Libé, Anne‐Paule Gimenez‐Roqueplo, Judith Favier, Marcus Quinkler, Christian J. Strasburger, Katrin Zopf, Martín Reincke, Matthias Kroiß, Hanna Remde, Michaela Haaf, Carmina Teresa Fuß, Ulrich Dischinger, Graeme Eisenhofer, Christina Pamporaki, Anouk van Berkel,
Background No randomised controlled trial has ever been done in patients with metastatic phaeochromocytomas and paragangliomas. Preclinical and first clinical evidence suggested beneficial effects of sunitinib. We aimed to evaluate the safety and efficacy of sunitinib in patients with metastatic phaeochromocytomas and paragangliomas. Methods FIRSTMAPPP is a multicentre, international, randomised, placebo-controlled, double-blind, phase 2 trial done at 14 academic centres across four European countries. ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2024 - Elsevier BV | The Lancet
Peter A.C. ‘t Hoen, Christian A.C. van der Lans, Miranda Van Eck, Martin K. Bijsterbosch, Theo J.C. van Berkel, Jaap Twisk,
Oxidative stress has been implicated in the development of atherosclerotic lesions. We evaluated the relationship between extent of atherosclerotic lesion formation and vascular expression of pro- and antioxidant enzymes in apoE-deficient mice. On normal chow, these mice showed elevated serum cholesterol levels (7.5- to 9.5-fold), and age-dependent, spontaneous development of all stages of atherosclerotic lesions, starting at the age of 12 weeks. RNA was extracted from the aortic arch and descending ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2003 - Lippincott Williams & Wilkins | Circulation Research