Nis Pedersen Jørgensen, Aage Kristian Olsen Alstrup, Frank Viborg Mortensen, Karoline Knudsen, Steen Jakobsen, Line Bille Madsen, Dirk Bender, Peter Breining, Mikkel Steen Petersen, Mariane Høgsberg Schleimann, Frederik Dagnæs‐Hansen, Lars Christian Gormsen, Per Borghammer,
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2016 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Bettina Hjelm Clausen, Kate Lykke Lambertsen, Frederik Dagnæs‐Hansen, Alicia A. Babcock, Christian Ulrich von Linstow, Michael Meldgaard, Bjarne Winther Kristensen, Tomas Deierborg, Bente Finsen,
Cell-based therapies are emerging as new promising treatments in stroke. However, their functional mechanism and therapeutic potential during early infarct maturation has so far received little attention. Here, we asked if cell-based delivery of the interleukin-1 receptor antagonist (IL-1Ra), a known neuroprotectant in stroke, can promote neuroprotection, by modulating the detrimental inflammatory response in the tissue at risk. We show by the use of IL-1Ra-overexpressing and IL-1Ra-deficient mice ...
Tópico(s): S100 Proteins and Annexins
2016 - Springer Science+Business Media | Acta Neuropathologica
Michael Knudsen, Dan Søndergaard, Claus Tofting-Olesen, Frederik T. Hansen, Ditlev E. Brodersen, Christian N. S. Pedersen,
Abstract Motivation: By using a class of large modular enzymes known as Non-Ribosomal Peptide Synthetases (NRPS), bacteria and fungi are capable of synthesizing a large variety of secondary metabolites, many of which are bioactive and have potential, pharmaceutical applications as e.g. antibiotics. There is thus an interest in predicting the compound synthesized by an NRPS from its primary structure (amino acid sequence) alone, as this would enable an in silico search of whole genomes for NRPS enzymes ...
Tópico(s): Biochemical and Structural Characterization
2015 - Oxford University Press | Bioinformatics
Frederik Clauson‐Kaas, Hans Christian Bruun Hansen, Bjarne W. Strobel,
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2016 - Springer Science+Business Media | Analytical and Bioanalytical Chemistry
Connie O’Driscoll, Carmel Ramwell, Brendan Harhen, Liam Morrison, Frederik Clauson‐Kaas, Hans Christian Bruun Hansen, G. D. Campbell, Jerome Sheahan, Bruce Misstear, Liwen Xiao,
Ptaquiloside, along with other natural phytotoxins, is receiving increased attention from scientists and land use managers. There is an urgent need to increase empirical evidence to understand the scale of phytotoxin mobilisation and potential to enter into the environment. In this study the risk of ptaquiloside to drinking water was assessed by quantifying ptaquiloside in the receiving waters at three drinking water abstraction sites across Ireland and in bracken fronds surrounding the abstraction ...
Tópico(s): Allelopathy and phytotoxic interactions
2016 - Multidisciplinary Digital Publishing Institute | Molecules
Simon Mark Dahl Baunwall, Mette Mejlby Hansen, Christian Erikstrup, Jens Frederik Dahlerup, Christian Lodberg Hvas,
Faecal microbiota transplantation (FMT) is currently being established as a second-line treatment for recurrent Clostridium difficile infection. FMT is further being considered for other infectious and inflammatory conditions. Safe and reproducible methods for donor screening, laboratory processing and clinical application of FMT are warranted.Here, we describe the development of a complete clinical application framework for FMT. The framework has been developed to comply with the European Tissue ...
Tópico(s): Gastrointestinal motility and disorders
2017 - Lippincott Williams & Wilkins | European Journal of Gastroenterology & Hepatology
Christian Lodberg Hvas, Simon Mark Dahl Baunwall, Søren Peter Jørgensen, Merete Storgaard, Lars Lemming, Mette Mejlby Hansen, Christian Erikstrup, Jens Frederik Dahlerup,
Fecal microbiota transplantation (FMT) is recommended for treatment of recurrent Clostridium difficile infection (rCDI). We performed a single-center randomized trial to compare the effects of FMT with those of fidaxomicin and vancomycin.We studied consecutive adults with rCDI seen at a gastroenterology clinic in Denmark from April 5, 2016 through June 10, 2018. Patients were randomly assigned to a group that received FMT, applied by colonoscopy or nasojejunal tube, after 4-10 days of vancomycin (125 ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2019 - Elsevier BV | Gastroenterology
Frederik Clauson‐Kaas, Carmel Ramwell, Hans Christian Bruun Hansen, Bjarne W. Strobel,
The bracken fern (Pteridium spp.) densely populates both open and woodland vegetation types around the globe. Bracken is toxic to livestock when consumed, and a group of potent illudane-type carcinogens have been identified, of which the compound ptaquiloside (PTA) is the most abundant. The highly water soluble PTA has been shown to be leachable from bracken fronds, and present in the soil and water below bracken stands. This has raised concerns over whether the compound might pose a risk to drinking ...
Tópico(s): Allelopathy and phytotoxic interactions
2016 - Elsevier BV | Water Research
Kate Lykke Lambertsen, Bettina Hjelm Clausen, Christina Fenger, Hans Christian Wulf, Trevor Owens, Frederik Dagnæs‐Hansen, Michael Meldgaard, Bente Finsen,
The proinflammatory and potential neurotoxic cytokine tumor necrosis factor (TNF) is produced by activated CNS resident microglia and infiltrating blood-borne macrophages in infarct and peri-infarct areas following induction of focal cerebral ischemia. Here, we investigated the expression of the TNF receptors, TNF-p55R and TNF-p75R, from 1 to 10 days following permanent occlusion of the middle cerebral artery in mice. Using quantitative polymerase chain reaction (PCR), we observed that the relative ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2006 - Elsevier BV | Neuroscience
A Nørgaard, Keld Kjeldsen, Olfred Hansen, Torben Clausen, Christian Grønhøj, Frederik Grønhøj Larsen,
Journal Article Quantification of the 3H-ouabain binding site concentration in human myocardium: a postmortem study Get access AAGE NØRGAARD, AAGE NØRGAARD **From the Institute of Physiology, University of Aarhus, Aarhus C, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar KELD KJELDSEN, KELD KJELDSEN **From the Institute of Physiology, University of Aarhus, Aarhus C, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar OTTO HANSEN, ...
Tópico(s): Receptor Mechanisms and Signaling
1986 - Oxford University Press | Cardiovascular Research
Matthew Helmi Leth Larsen, Frederik Dahl, Lars P. Hansen, Bastian Barton, Christian Kisielowski, Stig Helveg, Ole Winther, Thomas W. Hansen, Jakob Schiøtz,
Reconstruction of the exit wave function is an important route to interpreting high-resolution transmission electron microscopy (HRTEM) images. Here we demonstrate that convolutional neural networks can be used to reconstruct the exit wave from a short focal series of HRTEM images, with a fidelity comparable to conventional exit wave reconstruction. We use a fully convolutional neural network based on the U-Net architecture, and demonstrate that we can train it on simulated exit waves and simulated ...
Tópico(s): Advanced Electron Microscopy Techniques and Applications
2022 - Elsevier BV | Ultramicroscopy
Frederik Cold, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Andreas Munk Petersen, Christian Lodberg Hvas, Lars Hestbjerg Hansen,
Faecal microbiota transplantation (FMT) is an effective treatment of recurrent Clostridioides difficile infection (rCDI) and is being applied experimentally in other diseases. Encapsulated administration may be equivalent in efficacy to delivery through other routes.A systematic review was undertaken of studies using encapsulated FMT up to 26 October 2020. Data on indication, clinical outcomes, safety, treatment protocol and capsule preparation were collected and reported. Pooled rates of clinical ...
Tópico(s): Gut microbiota and health
2021 - SAGE Publishing | Therapeutic Advances in Gastroenterology
Ashot Margaryan, Christina Lehmkuhl Noer, Stine R. Richter, Marlene Elise Møller Restrup, Julie Lee Bülow‐Hansen, Frederik Leerhøi, Emilia Langkjær, Shyam Gopalakrishnan, Christian Carøe, M. Thomas P. Gilbert, Kristine Bohmann,
Abstract Biodiversity monitoring projects using environmental DNA techniques are becoming increasingly widespread. However, these techniques depend heavily on the quality and richness of the available DNA reference database against which the DNA sequences are queried. To create a comprehensive DNA sequence database for future DNA‐based biodiversity assessments in Denmark, a national DNA reference database, DNAmark, was established, which contains organellar and/or nuclear reference data from vouchered ...
Tópico(s): Identification and Quantification in Food
2020 - Wiley | Environmental DNA
Gitte Krogh Nielsen, Frederik Dagnæs‐Hansen, Ida E. Holm, Steve Meaney, Derek J. Symula, Niels Trolle Andersen, Christian W. Heegaard,
Niemann-Pick type C2 (NPC2) disease is a fatal autosomal recessive neurovisceral degenerative disorder characterized by late endosomal-lysosomal sequestration of low-density lipoprotein derived cholesterol. The breach in intracellular cholesterol homeostasis is caused by deficiency of functional NPC2, a soluble sterol binding protein targeted to the lysosomes by binding the mannose-6-phosphate receptor. As currently there is no effective treatment for the disorder, we have investigated the efficacy ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2011 - Public Library of Science | PLoS ONE
Ida Rask Moustsen-Helms, Peter Bager, Tine Graakjær Larsen, Frederik Trier Møller, Lasse S Vestergaard, Morten Rasmussen, Christian Holm Hansen,
During the 2023 Danish COVID-19 vaccination campaign, an updated monovalent mRNA vaccine targeting the SARS-CoV-2 omicron XBB.1.5 subvariant was administered. However, the rapid spread of a genetically divergent omicron BA.2.86 subvariant, JN.1, since September, 2023, poses potential challenges due to its rapid dominance and possible immune escape. Using national electronic health registry data from all regions of Denmark, we aimed to investigate whether the SARS-CoV-2 subvariant BA.2.86, and its ...
Tópico(s): vaccines and immunoinformatics approaches
2024 - Elsevier BV | The Lancet Infectious Diseases
Line S. Reinert, Louis Harder, Christian K. Holm, Marie B. Iversen, Kristy Horan, Frederik Dagnæs‐Hansen, Benedicte Parm Ulhøi, Thomas Hellesøe Holm, Trine H. Mogensen, Trevor Owens, Jens R. Nyengaard, Allan Randrup Thomsen, Søren R. Paludan,
Herpes simplex viruses (HSVs) are highly prevalent neurotropic viruses. While they can replicate lytically in cells of the epithelial lineage, causing lesions on mucocutaneous surfaces, HSVs also establish latent infections in neurons, which act as reservoirs of virus for subsequent reactivation events. Immunological control of HSV involves activation of innate immune pattern-recognition receptors such as TLR3, which detects double-stranded RNA and induces type I IFN expression. Humans with defects ...
Tópico(s): interferon and immune responses
2012 - American Society for Clinical Investigation | Journal of Clinical Investigation
Julie Svalø, Henrik H. Hansen, Lars Christian B. Rønn, Majid Sheykhzade, Gordon Munro, Frederik Rode,
Abstract: The effects of the K v 7 channel modulators retigabine (opener) and XE991 (blocker) on rat bladder function were investigated ex vivo and in vivo to assess the potential of K v 7 openers for the treatment of overactive bladder. In organ bath studies, capsaicin‐stimulated rat urinary bladder rings were exposed to retigabine and XE991 and the effect on tension and amplitude was evaluated. In anaesthetized rats, retigabine (0.01–1 mg/kg, i.v.) effects on bladder function, in which overactivity ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2011 - Wiley | Basic & Clinical Pharmacology & Toxicology
Mustafa Abdo, Benjamin Waschki, Anne‐Marie Kirsten, Frederik Trinkmann, Heike Biller, Christian Herzmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz,
Asthma, obesity and physical activity (PA) are interrelated. However, longitudinal data with objective PA measures and direct assessment of body composition are still lacking.To study the impact of symptom control on PA and body composition.In a longitudinal cohort study of the German Center for Lung Research, we assessed the body composition of 233 asthma patients and 84 healthy controls using bioelectrical impedance analysis. PA (ie average daily steps and time of at least moderate activity, steps/ ...
Tópico(s): Body Composition Measurement Techniques
2021 - Dove Medical Press | Journal of Asthma and Allergy
Jens Laurids Sørensen, Michael Knudsen, Frederik T. Hansen, Claus Olesen, Patricia Romans Fuertes, T. Verne Lee, Teis Esben Søndergaard, Christian N. S. Pedersen, Ditlev E. Brodersen, Henriette Giese,
Iron is an essential, yet often limiting element for the growth of many organisms. In response to iron limitation, fungi have developed siderophores that provide a high-affinity iron uptake system and safe intracellular storage and transport mechanisms to gain a competitive advantage. Here, we discuss the function of siderophores in relation to fungal iron uptake mechanisms and their importance for coexistence with host organisms. The chemical nature of the major groups of siderophores and their ...
Tópico(s): Polysaccharides and Plant Cell Walls
2014 - Springer International Publishing | Fungal biology
Frederik Clauson‐Kaas, Pia H. Jensen, Ole Stig Jacobsen, René K. Juhler, Hans Christian Bruun Hansen,
The present study demonstrates unequivocally the presence of the natural carcinogen ptaquiloside and its transformation product pterosin B in groundwater and surface water. Groundwater concentrations up to 0.23 nmol/L (92 ng/L) ptaquiloside and up to 2.2 nmol/L (0.47 µg/L) pterosin B were found. Of 21 groundwater samples, 5 contained ptaquiloside, exceeding the estimated threshold for drinking water (1.3-40 pmol/L). The results are critical for water abstraction in bracken-infested areas.
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2014 - Wiley | Environmental Toxicology and Chemistry
Frederik Zahle, Carlo Tibaldi, Christian Pavese, Michael McWilliam, José Pedro Albergaria Amaral Blasques, Morten Hartvig Hansen,
This work presents an integrated multidisciplinary wind turbine optimization framework utilizing state-of-the-art aeroelastic and strutural tools, capable of simultaneous design of the outer geometry and internal structure of the blade. The framework is utilized to design a 10 MW rotor constrained not to exceed the design loads of an existing reference wind turbine. The results show that through combined geometric tailoring of the internal structure and aerodynamic shape of the blade it is possible ...
Tópico(s): Probabilistic and Robust Engineering Design
2016 - IOP Publishing | Journal of Physics Conference Series
Matthias Kochanek, Jan Kochanek, Boris Böll, Dennis A. Eichenauer, Gernot Beutel, Hendrik Bracht, Stephan Braune, Florian Eisner, Sigrun Friesecke, Ulf Günther, Gottfried Heinz, Michael Hallek, Christian Karagiannidis, Stefan Kluge, Klaus Kogelmann, Pia Lebiedz, Philipp M. Lepper, Tobias Liebregts, Catherina Lueck, Ralf M. Muellenbach, Matthias Hansen, Christian Putensen, Peter Schellongowski, Jens‐Christian Schewe, Kathrin Schumann-Stoiber, Frederik Seiler, Peter M. Spieth, Steffen Weber‐Carstens, Daniel Brodie, Élie Azoulay, Alexander Shimabukuro‐Vornhagen,
The question of whether cancer patients with severe respiratory failure benefit from veno-venous extracorporeal membrane oxygenation (vv-ECMO) remains unanswered. We, therefore, analyzed clinical characteristics and outcomes of a large cohort of cancer patients treated with vv-ECMO with the aim to identify prognostic factors. 297 cancer patients from 19 German and Austrian hospitals who underwent vv-ECMO between 2009 and 2019 were retrospectively analyzed. A multivariable cox proportional hazards ...
Tópico(s): Cardiac Structural Anomalies and Repair
2022 - Springer Science+Business Media | Intensive Care Medicine
Frederik Neess Engsig, Ann‐Brit Eg Hansen, Lars Haukali Omland, Gitte Kronborg, Jan Gerstoft, Alex Lund Laursen, Court Pedersen, Christian Backer Mogensen, Lars N. Nielsen, Niels Obel,
Background. Human immunodeficiency virus (HIV) infection predisposes to progressive multifocal leukoencephalopathy (PML). Here, we describe the incidence, presentation, and prognosis of PML in HIV-1-infected patients during the period before highly active antiretroviral therapy (HAART) (1995–1996) and during the early HAART (1997–1999) and late HAART (2000–2006) periods. Methods. Patients from a nationwide population-based cohort of adult HIV-1-infected individuals were included. We calculated incidence ...
Tópico(s): Viral-associated cancers and disorders
2008 - Oxford University Press | The Journal of Infectious Diseases
Mustafa Abdo, Frederik Trinkmann, Anne‐Marie Kirsten, Frauke Pedersen, Christian Herzmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Benjamin Waschki, Klaus F. Rabe, Henrik Watz, Thomas Bahmer,
BackgroundLittle is known about the role of small airway dysfunction (SAD) and its complex relation with asthma control and physical activity (PA).ObjectiveTo investigate the interrelations among SAD, risk factors for asthma severity, symptom control, and PA.MethodsWe assessed SAD by impulse oscillometry and other sophisticated lung function measures including inert gas washout in adults with asthma (mild to moderate, n = 140; severe, n = 128) and 69 healthy controls from the All Age Asthma Cohort. We ...
Tópico(s): Respiratory and Cough-Related Research
2021 - Elsevier BV | The Journal of Allergy and Clinical Immunology In Practice
Frederik Westergaard Østerberg, Bjarke Thomas Dalslet, Christian Danvad Damsgaard, Susana Cardoso, P. P. Freitas, Mikkel Fougt Hansen,
The accumulation of magnetic beads by gravitational sedimentation and magnetic capture on a planar Hall-effect sensor integrated in a microfluidic channel is studied systematically as a function of the bead concentration, the fluid flow rate, and the sensor bias current. It is demonstrated that the sedimentation flux is proportional to the bead concentration and has a power law relation to the fluid flow rate. The mechanisms for the bead accumulation are investigated and it is found that gravitational ...
Tópico(s): Microfluidic and Bio-sensing Technologies
2009 - IEEE Sensors Council | IEEE Sensors Journal
Christer Halldin, Christian Foged, Lars Farde, Per Karlsson, Kristian T. Hansen, Frederik C. Grønvald, Carl‐Gunnar Swahn, Håkan Hall, Göran Sedvall,
NNC 687 and NNC 756 [(+)-5-(2,3-dihydrobenzofuran-7-yl)-7-hydroxy-3-methyl-8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine and (+)-8-chloro-5-(2,3-dihydrobenzofuran-7-yl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine] are two new potent dopamine D-1 receptor antagonists. [11C]NNC 687 and [11C]NNC 756 were both prepared by N-methylation of the corresponding desmethyl compounds with [11C]methyl iodide. The reactions were performed in acetone with subsequent normal-phase semi-preparative HPLC and resulting ...
Tópico(s): Neuroscience and Neuropharmacology Research
1993 - Elsevier BV | Nuclear Medicine and Biology
Lone Fisker Christensen, Frederik Alkier Gildberg, Christian Sibbersen, Mette Maria Skjoeth, Connie Thurøe Nielsen, Jens Peter Hansen,
Aim: To evaluate whether there was a difference in satisfaction scores between providers and patients in the use of videoconferences (VCs) by depressed adults. Method: This study was a subanalysis of the joint European project, MasterMind, and participants were recruited from 15 pilot studies in 11 different countries. The Client Satisfaction Questionnaire (CSQ)-3 was used as assessment tool, and scores were summed to give total scores. The questionnaire consists of three items evaluating general ...
Tópico(s): Patient-Provider Communication in Healthcare
2019 - Mary Ann Liebert, Inc. | Telemedicine Journal and e-Health
Lone Fisker Christensen, Frederik Alkier Gildberg, Christian Sibbersen, Mette Maria Skjoeth, Connie Thurøe Nielsen, Jens Peter Hansen,
Aim: To investigate whether there is a correlation between age and satisfaction with the use of videoconferences (VCs) and whether the number of video sessions had an impact on satisfaction. Methods: This study was a subanalysis of the joint European project, MasterMind, and participants were recruited from15 pilot studies in 11 different countries. The Client Satisfaction Questionnaire 8 (CSQ 8) was used as assessment tool, and scores were summed to give total scores. Results: Participants were included ...
Tópico(s): Patient Satisfaction in Healthcare
2019 - Mary Ann Liebert, Inc. | Telemedicine Journal and e-Health
Vardan Nersesjan, Moshgan Amiri, Anne‐Mette Lebech, Casper Roed, Helene Mens, Lene Russell, Lise Fonsmark, Marianne Berntsen, Sigurður Þór Sigurðsson, Jonathan Frederik Carlsen, Annika Reynberg Langkilde, Pernille Martens, Eva Løbner Lund, Klaus Hansen, Bo Jespersen, Marie Norsker Folke, Per Meden, Anne‐Mette Hejl, Christian Wamberg, Michael E. Benros, Daniel Kondziella,
To systematically describe central (CNS) and peripheral (PNS) nervous system complications in hospitalized COVID-19 patients.We conducted a prospective, consecutive, observational study of adult patients from a tertiary referral center with confirmed COVID-19. All patients were screened daily for neurological and neuropsychiatric symptoms during admission and discharge. Three-month follow-up data were collected using electronic health records. We classified complications as caused by SARS-CoV-2 neurotropism, ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Springer Science+Business Media | Journal of Neurology
Eirini Skourti-Stathaki, Frederik Clauson‐Kaas, Kristian K. Brandt, Lars Holm Rasmussen, Hans Christian Bruun Hansen,
Bracken ferns (Pteridium spp.) are well-known for their carcinogenic properties, which are ascribed to the content of ptaquiloside and ptaquiloside-like substances. Ptaquiloside leach from the ferns and may cause contamination of drinking water. Pterosin B is formed by hydrolysis of ptaquiloside. In soil, Pterosin B is adsorbed more strongly and it is expected to have a slower turnover than ptaquiloside. We thus hypothesized that pterosin B may serve as an indicator for any past presence of ptaquiloside. ...
Tópico(s): Glutathione Transferases and Polymorphisms
2016 - Elsevier BV | Chemosphere