Pascale Moreau, Fabrice Anizon, Martine Sancelme, Michelle Prudhomme, Christian Bailly, Danièle Sevère, Jean‐François Riou, Doriano Fabbro, Thomas Meyer, Anné-Marie Aubertin,
In the course of structure−activity relationships on rebeccamycin analogues, a series of compounds bearing a halogenoacetyl substituent were synthesized with the expectation of increasing the interaction with DNA, possibly via covalent reaction with the double helix. Two rebeccamycin analogues bearing an acetyl instead of a bromoacetyl substituent were prepared to gain an insight into the role of the halogen atom. The new compounds show very little effect on protein kinase C and no covalent reaction ...
Tópico(s): Bioactive Compounds and Antitumor Agents
1999 - American Chemical Society | Journal of Medicinal Chemistry
Pascale Moreau, Fabrice Anizon, Martine Sancelme, Michelle Prudhomme, Christian Bailly, Carolina Carrasco, Monique Ollier, Danièle Sevère, Jean‐François Riou, Doriano Fabbro, Thomas Meyer, Anné-Marie Aubertin,
A series of 10 indolocarbazole derivatives, analogues to the antitumor antibiotic rebeccamycin, bearing modifications at the imide heterocycle were synthesized. They bear an N-methyl imide, N-methyl amide, or anhydride function instead of the original imide. Their inhibitory potencies toward topoisomerase I were examined using a DNA relaxation assay and by analyzing the drug-induced cleavage of 32P-labeled DNA. Protein kinase C (PKC) inhibition and interaction with DNA were also studied together ...
Tópico(s): Fungal Infections and Studies
1998 - American Chemical Society | Journal of Medicinal Chemistry
M.L. Piel-Julian, Matthieu Mahévas, Johanne Germain, Laetitia Languille, Thibault Comont, Maryse Lapeyre‐Mestre, Bernard Payrastre, O. Beyne‐Rauzy, Marc Michel, Bertrand Godeau, D. Adoué, Guillaume Moulis, Laurent Alric, S. Arista, L. Astudillo, Laurent Balardy, Sarah Bétrian, Delphine Bonnet, Cécile Borel, Delphine Bréchemier, Natacha Brun, M. Carreiro, B. Castel, L. Caudrelier, P. Cougoul, A. Danu, K. Delavigne, C. Dingremont, T. Faurie, F. Gaches, M Gaspard, C. Gaudin, Aurélie Godel-Labouret, P Giraud, S. Hadj‐Khelifa, Benjamin Hébraud, Sarah Khatibi, Lorraine Leplay, Y. Leveneur, Nicolas Limal, S. Ollier, S. Madaule, B. Marchou, C. Martel, Guillaume Martin‐Blondel, Philippe Montané de la Roque, Martin Michaud, J. Moeglin, F. Nuccio, L. Prudhomme, G. Pugnet, Christian Récher, Véronique Rémy, L. Sailler, Stéphane Sire, Agnès Sommet, Suzanne Tavitian, M.F. Thiercelin-Legrand, W. Vaillant,
Essentials Risk factors of bleeding in adult immune thrombocytopenia are not known. This multicenter study assessed risk factors of bleeding at immune thrombocytopenia onset. Platelet count thresholds associated with bleeding were < 20 × 109 L-1 and < 10 × 109 L-1 . Exposure to anticoagulants was a major risk factor of severe bleeding.Background The aim of this cross-sectional study was to assess risk factors for bleeding in immune thrombocytopenia (ITP) adults, including the determination of platelet count ...
Tópico(s): Blood properties and coagulation
2018 - Elsevier BV | Journal of Thrombosis and Haemostasis
Karine Rottier, Alexandre Faille, Thomas Prudhomme, Cécile Leblanc, Christian Chalut, Stéphanie Cabantous, Christophe Guilhot, Lionel Mourey, J.D. Pédelacq,
The need for early-on diagnostic tools to assess the folding and solubility of expressed protein constructs in vivo is of great interest when dealing with recalcitrant proteins. In this paper, we took advantage of the picomolar sensitivity of the bipartite GFP1–10/GFP11 system to investigate the solubility of the Mycobacterium tuberculosis 4′-phosphopantetheinyl transferase PptT, an enzyme essential for the viability of the tubercle bacillus. In vivo and in vitro complementation assays clearly showed ...
Tópico(s): Microbial Natural Products and Biosynthesis
2013 - Elsevier BV | Journal of Structural Biology
Yannick Thomas, B. Marsset, Stéphane Didailler, Jean-Pierre Regnault, Sandie Le Conte, Dominique Roux, Patrick Farcy, Maurice Magueur, Pascal Viollette, Jacques Herveou, Jean-Charles Guedes, Bernard Jegot, Gilles Gascon, Christian Prudhomme, Hervé Nouzé, Estelle Thereau, Isabelle Contrucci, Jean‐Paul Foucher,
Cette note présente les résultats technologiques et les premières mesures issus du développement d'une méthode de reconnaissance sismique marine haute résolution 3D à destination de la communauté scientifique. Une attention particulière a été portée à la réalisation d'un système opérationnel en adéquation avec les objectifs visés en termes de mise en œuvre et de traitement. Le dispositif a été transféré durant l'année 2003 dans le parc d'équipements communs. Pour citer cet article : Y. Thomas et al., ...
Tópico(s): Seismology and Earthquake Studies
2004 - Elsevier BV | Comptes Rendus Géoscience
Guillaume Moulis, Johanne Germain, Thibault Comont, A. Arrouy, Maryse Lapeyre‐Mestre, D. Adoué,
... Moeglin, Fanny Nuccio, Marie-Léa Piel-Julian, Laurent Prudhomme, Grégory Pugnet, Christian Recher, Véronique Remy, Laurent Sailler, Stéphane Sire, Agnès ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2018 - Wiley | American Journal of Hematology
Alexander Mathis, Jérôme Depaquit, Vít Dvořák, Holly C. Tuten, Anne‐Laure Bañuls, Petr Halada, Sonia Zapata, Véronique Lehrter, Kristýna Hlavačková, Jorian Prudhomme, Petr Volf, Denis Séréno, Christian Kaufmann, Valentin Pflüger, Francis Schaffner,
Rapid, accurate and high-throughput identification of vector arthropods is of paramount importance in surveillance programmes that are becoming more common due to the changing geographic occurrence and extent of many arthropod-borne diseases. Protein profiling by MALDI-TOF mass spectrometry fulfils these requirements for identification, and reference databases have recently been established for several vector taxa, mostly with specimens from laboratory colonies.We established and validated a reference ...
Tópico(s): Viral Infections and Vectors
2015 - BioMed Central | Parasites & Vectors
Aline Voldoire, Martine Sancelme, Michelle Prudhomme, Pierre Colson, Claude Houssier, Christian Bailly, Stéphane Léonce, Stéphanie Lambel,
Glycosylated indolocarbazoles related to the antibiotic rebeccamycin represent an important series of antitumor drugs. In the course of structure-activity relationship studies, we report the synthesis of two new derivatives containing an indolo[2,3-c]carbazole chromophore instead of the conventional indolo[2,3-a]carbazole unit found in the natural metabolites. The N-methylated compound 8 containing one glucose residue behaves as a typical DNA intercalating agent, as judged from circular and electric ...
Tópico(s): Fungal Infections and Studies
2001 - Elsevier BV | Bioorganic & Medicinal Chemistry
Fabrice Anizon, Pascale Moreau, Martine Sancelme, William Laine, Christian Bailly, Michelle Prudhomme,
In the course of structure–activity relationship studies on rebeccamycin analogues, a series of compounds bearing an amino function on the sugar moiety were synthesized with the aim of improving the solubility and interaction with the macromolecular target(s). The syntheses of amino derivatives and the corresponding chloro, iodo and azido intermediates are described. Their interaction with DNA and effects on human DNA topoisomerases I and II were investigated. Their antimicrobial activities against ...
Tópico(s): Antibiotic Resistance in Bacteria
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry
Paola B. Arimondo, Pascale Moreau, Alexandre S. Boutorine, Christian Bailly, Michelle Prudhomme, Jian‐Sheng Sun, Thérèse Garestier, Claude Hélène,
Tópico(s): Synthesis and Biological Evaluation
2000 - Elsevier BV | Bioorganic & Medicinal Chemistry
Fabrice Anizon, Pascale Moreau, Martine Sancelme, Aline Voldoire, Michelle Prudhomme, Monique Ollier, Danièle Sevère, Jean‐François Riou, Christian Bailly, Doriano Fabbro, Thomas Meyer, A.‐M. Aubertin,
The indolocarbazole antibiotics staurosporine and rebeccamycin (1) are potent antitumor drugs targeting protein kinase C and topoisomerase I, respectively. To obtain staurosporine analogues from rebeccamycin, different structural modifications were performed: coupling of the sugar moiety to the second indole nitrogen, dechlorination and then reduction of the imide function to amide. The newly synthesized compounds (3-6) were tested for their abilities to bind to DNA and to inhibit topoisomerase I ...
Tópico(s): Bioactive Compounds and Antitumor Agents
1998 - Elsevier BV | Bioorganic & Medicinal Chemistry
Fabrice Anizon, Laure Belin, Pascale Moreau, Martine Sancelme, Aline Voldoire, Michelle Prudhomme, Monique Ollier, Danièle Sevère, Jean‐François Riou, Christian Bailly, Doriano Fabbro, Thomas Meyer,
As a part of studies on structure−activity relationships, several potential topoisomerase I inhibitors were prepared. Different analogues of the antitumor antibiotic rebeccamycin substituted on the imide nitrogen with a methyl group were synthesized. These compounds bore either the sugar residue of rebeccamycin, with or without the chlorine atoms on the indole moieties, or modified sugar residues (galactopyranosyl, glucopyranosyl, or fucopyranosyl) linked to the aglycone via a β- or α-N-glycosidic ...
Tópico(s): Bioactive Compounds and Antitumor Agents
1997 - American Chemical Society | Journal of Medicinal Chemistry
M. Prudhomme, D. Le Nen, Christian Lefèvre, F. Dubrana, Éric Stindel, B. Sénécail,
Tópico(s): Nerve Injury and Rehabilitation
2001 - Springer Science+Business Media | Surgical and Radiologic Anatomy
Pascale Moreau, Fabrice Anizon, Martine Sancelme, Michelle Prudhomme, Danièle Sevère, Jean‐François Riou, Jean‐François Goossens, Jean‐Pierre Hénichart, Christian Bailly, Emmanuel Labourier, Jamal Tazzi, Doriano Fabbro, Thomas Meyer, A.‐M. Aubertin,
Bromo analogues of the natural metabolite rebeccamycin with and without a methyl substituent on the imide nitrogen were synthesized. The effects of the drugs on protein kinase C, the binding to DNA, and the effect on topoisomerase I were determined. The drugs' uptake and their antiproliferative activities against P388 leukemia cells sensitive and resistant to camptothecin, their antimicrobial activity against a Gram-positive bacterium (B. cereus), and their anti-HIV-1 activity were measured and compared ...
Tópico(s): Bioactive Compounds and Antitumor Agents
1999 - American Chemical Society | Journal of Medicinal Chemistry
Cécile Leblanc, Thomas Prudhomme, Guillaume Tabouret, Aurélie Ray, Sophie Burbaud, Stéphanie Cabantous, Lionel Mourey, Christophe Guilhot, Christian Chalut,
The cell envelope of Mycobacterium tuberculosis, the causative agent of tuberculosis in humans, contains lipids with unusual structures. These lipids play a key role in both virulence and resistance to the various hostile environments encountered by the bacteria during infection. They are synthesized by complex enzymatic systems, including type-I polyketide synthases and type-I and -II fatty acid synthases, which require a post-translational modification to become active. This modification consists ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2012 - Public Library of Science | PLoS Pathogens
Christian Bailly, Xiaogang Qu, Fabrice Anizon, Michelle Prudhomme, Jean‐François Riou, Jonathan B. Chaires,
Many antitumor agents contain a carbohydrate side chain appended to a DNA-intercalating chromophore. This is the case with anthracyclines such as daunomycin and also with indolocarbazoles including the antibiotic rebeccamycin and its tumor active analog, NB506. In each case, the glycoside residue plays a significant role in the interaction of the drug with the DNA double helix. In this study we show that the DNA-binding affinity and sequence selectivity of a rebeccamycin derivative can be enhanced ...
Tópico(s): Microbial Natural Products and Biosynthesis
1999 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Aline Voldoire, Pascale Moreau, Martine Sancelme, Mária Matulová, Stéphane Léonce, Alain St. Pierre, John A. Hickman, Bruno Pfeiffer, Pierre Renard, Nathalie Dias, Christian Bailly, Michelle Prudhomme,
la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Tópico(s): Fungal Plant Pathogen Control
2004 - Elsevier BV | Bioorganic & Medicinal Chemistry
Christelle Marminon, Alain St. Pierre, Bruno Pfeiffer, Valérie Perez, Stéphane Léonce, Alexandra Joubert, Christian Bailly, Pierre Renard, John A. Hickman, Michelle Prudhomme,
Rebeccamycin analogues containing one azaindole unit, with and without a methyl group on the imide nitrogen and with the sugar moiety coupled either to the indole nitrogen or to the azaindole nitrogen were synthesized. To increase the solubility and induce stronger interactions with the target macromolecules, a bromo or nitro substitutent was introduced on the indole unit. The DNA binding and topoisomerase I inhibition properties were investigated together with the antiproliferative activities toward ...
Tópico(s): Synthesis and Biological Activity
2003 - American Chemical Society | Journal of Medicinal Chemistry
Christian Bailly, Xiaogang Qu, David E. Graves, Michelle Prudhomme, Jonathan B. Chaires,
Only a few antitumor drugs inhibit the DNA breakage-reunion reaction catalyzed by topoisomerase. One is the camptothecin derivative topotecan that has recently been used clinically. Others are the glycosylated antibiotic rebeccamycin and its synthetic analog NB-506, which is presently in phase I of clinical trials. Unlike the camptothecins, rebeccamycin-type compounds bind to DNA. We set out to elucidate the molecular basis of their interaction with duplex DNA, with particular emphasis on the role ...
Tópico(s): Bioactive Compounds and Antitumor Agents
1999 - Elsevier BV | Chemistry & Biology
Paola B. Arimondo, Christian Bailly, Alexandre S. Boutorine, Pascale Moreau, Michelle Prudhomme, Jian‐Sheng Sun, Thérèse Garestier, Claude Hélène,
Topoisomerase I is an ubiquitous DNA-cleaving enzyme and an important therapeutic target in cancer chemotherapy for camptothecins as well as for indolocarbazole antibiotics such as rebeccamycin. To achieve a sequence-specific cleavage of DNA by topoisomerase I, a triple helix-forming oligonucleotide was covalently linked to indolocarbazole-type topoisomerase I poisons. The three indolocarbazole−oligonucleotide conjugates investigated were able to direct topoisomerase I cleavage at a specific site ...
Tópico(s): Neutropenia and Cancer Infections
2001 - American Chemical Society | Bioconjugate Chemistry
Erkka Valovirta, Thomas Houmann Petersen, Teresa Piotrowska, Mette K. Laursen, Jens Andersen, Helle F. Sørensen, Rabih Klink, Eva‐Maria Varga, Isidor Huttegger, Lone Agertoft, Susanne Halken, Inger Merete Jørgensen, L. G. Hansen, Roswitha Cronjäger, Kirsten Hansen, Thomas Houmann Petersen, Sune Rubak, Erkka Valovirta, Péter Csonka, Ove Mickelsson, J. de Blic, N. Pham Thi, L. Réfabert, Christine Pasquet, A. Broué-Chabbert, Agnès Juchet, Bruno Lebeaupin, François Durand-Perdriel, F. Wessel, F. Payot, B. Girodet, Jean-Marc Houssel, Sylvie-Anne André-Gomez, Françoise Riotte-Flandrois, Dominique Basset, Dominique Mounier, Marie Noëlle Robberecht, Laure Delbecque, Rabih Klink, Jean‐Luc Fauquert, A. Prudhomme, Annick Auffret, Béatrice Luet-Gautier, Montserrat Agell Perello, Fabrice Bouillot, Albrecht Bufe, Andrea von Berg, Monika Gappa, Christian Vogelberg, Eckhard Hamelmann, U. Schauer, Volker Stephan, Peter Eberle, Raffi Bedikian, Peter Bosch, Jutta Christmann, E. Franke, Marcus Dahlheim, Friedrich Kaiser, Roland Knecht, B Sandner, Christine Gronke, Ralph Köllges, Eivy Franke-Beckmann, Ludger Klimek, Matthias Hoffmann, Ingrid Bretschneider, Aud Katrine Herland Berstad, Bente Kvenshagen, Knut Øymar, Bjarne Dag Andersen, E Kolsrud, Anne Søyland, Andrzej Dyczek, Juliusz Bokiej, T Hofman, Ewa Springer, Maria Zofia Lisiecka, Anna Madaj, Teresa Piotrowska, Ewa Trębas-Pietraś, Krzysztof Wytrychowski, Malgorzata Zurowska Żurowska-Gębala, Danuta Moszyńska, A Kwaśniewski, Pedro Ojeda, Ma Dolores Ibáñez, M Cimarra, Sonsoles Infante, Santiago Quirce, E López González, A. E. M. Vega, Carmen Panizo, Ana I. Tabar, Carmen Vidal, Alicia Alonso Gómez, Beatriz Fernández Parra, Inger Winnergård, Hampus Kiotseridis, P. Söderman, Johan Alm, Jan-Åke Jönsson, Anders Berner, Östen Jonsson, Lennart Nilsson, Alice Koehli-Wiesner, Peter Schmid‐Grendelmeier, Peter Eng, Graham Roberts, Rajiv Sood, Adam Fox, Adnan Ćustović,
Allergy immunotherapy targets the immunological cause of allergic rhinoconjunctivitis and allergic asthma and has the potential to alter the natural course of allergic disease.The primary objective was to investigate the effect of the SQ grass sublingual immunotherapy tablet compared with placebo on the risk of developing asthma.A total of 812 children (5-12 years), with a clinically relevant history of grass pollen allergic rhinoconjunctivitis and no medical history or signs of asthma, were included ...
Tópico(s): Dermatology and Skin Diseases
2017 - Elsevier BV | Journal of Allergy and Clinical Immunology
Christian Bailly, Carolina Carrasco, François Hamy, Hervé Vezin, Michelle Prudhomme, Ahamed Saleem, Eric H. Rubin,
DNA topoisomerase I is a major cellular target for antitumor indolocarbazole derivatives (IND) such as the antibiotic rebeccamycin and the synthetic analogue NB-506 which is undergoing phase I clinical trials. We have investigated the mechanism of topoisomerase I inhibition by a rebeccamycin analogue, R-3, using the wild-type human topoisomerase I and a well-characterized recombinant enzyme, F361S. The catalytic activity of this mutant remains fully intact, but the enzyme is resistant to inhibition ...
Tópico(s): Bioactive Compounds and Antitumor Agents
1999 - American Chemical Society | Biochemistry
Christian Bailly, Pierre Colson, Claude Houssier, Elisabète Rodrigues-Pereira, Michelle Prudhomme, Michael J. Waring,
We investigated the interaction with DNA of two synthetic derivatives of the antitumor antibiotic rebeccamycin: R- 3 , which is a potent topoisomerase I inhibitor and contains a methoxyglucose moiety appended to the indolocarbazole chromophore, and its aglycone, R- 4 . Spectroscopic measurements indicate that R- 3 intercalates into DNA and that its carbohydrate domain contributes significantly to reinforce the affinity for DNA. Two complementary ligation assays concur that R- 3 , but not its aglycone ...
Tópico(s): Synthesis and biological activity
1998 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Christian Bailly, Jean‐François Goossens, William Laine, Fabrice Anizon, Michelle Prudhomme, Jinsong Ren, Jonathan B. Chaires,
Rebeccamycin derivatives represent a promising class of antitumor agents. In this series, two glycosylated indolocarbazoles, NB-506 and NSC-655649, are currently undergoing clinical trials. Their anticancer activities are associated with their capacities to interact with DNA and to inhibit DNA topoisomerases. Previous studies revealed that the planar indolocarbazole chromophore can intercalate into DNA, locating the appended carbohydrate residue in one of the two helical grooves, probably the minor ...
Tópico(s): Antibiotic Resistance in Bacteria
2000 - American Chemical Society | Journal of Medicinal Chemistry
Claire Roubaud‐Baudron, Christian Pagnoux, N. Méaux-Ruault, A. Grasland, A. Zoulim, J. Le Guen, A. Prudhomme, Boris Bienvenu, Mathilde de Menthon, Sandra Camps, Véronique Le Guern, Achille Aouba, Pascal Cohen, Luc Mouthon, Loı̈c Guillevin,
To evaluate the efficacy compared to the relapse risk and tolerance of systematic rituximab (RTX) infusions as maintenance therapy for patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), who entered remission taking conventional immunosuppressants or RTX.A retrospective study of the main clinical characteristics, outcomes, and RTX tolerance of patients who had received ≥ 2 RTX maintenance infusions in our center, regardless of induction regimen, between 2003 and 2010. ...
Tópico(s): Sarcoidosis and Beryllium Toxicity Research
2011 - The Journal of Rheumatology Publishing Company Limited | The Journal of Rheumatology
Pascale Moreau, Nathalie Gaillard, Christelle Marminon, Fabrice Anizon, Nathalie Dias, Brigitte Baldeyrou, Christian Bailly, Alain St. Pierre, John A. Hickman, Bruno Pfeiffer, Pierre Renard, Michelle Prudhomme,
In the course of structure-activity relationship studies, new rebeccamycin derivatives substituted in 3,9-positions on the indolocarbazole framework, and a 2',3'-anhydro derivative were prepared by semi-synthesis from rebeccamycin. The antiproliferative activities against nine tumor cell lines were determined and the effect on the cell cycle of murine leukemia L1210 cells was examined. Their DNA binding properties and inhibitory properties toward topoisomerase I and three kinases PKCzeta, CDK1/cyclin ...
Tópico(s): Synthesis and Biological Activity
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry
Pascale Moreau, Martine Sancelme, Christian Bailly, Stéphane Léonce, Alain St. Pierre, John A. Hickman, Bruno Pfeiffer, Michelle Prudhomme,
Three indolocarbazole compounds bearing a tripeptide or a lysine group attached to one of the indole nitrogens via a propylamino chain and two rebeccamycin derivatives bearing a lysine residue on the sugar moiety were synthesised with the aim of improving the binding to DNA and the antiproliferative activities. Four tumour cell lines, from murine L1210 leukemia, human HT29 colon carcinoma, A549 non-small cell lung carcinoma and K-562 leukemia, were used to evaluate the cytotoxicity of the drugs. ...
Tópico(s): Microbial Natural Products and Biosynthesis
2001 - Elsevier BV | European Journal of Medicinal Chemistry
Christian Bailly, Jean‐François Riou, Pierre Colson, Claude Houssier, Elisabète Rodrigues-Pereira, Michelle Prudhomme,
DNA topoisomerase I has been shown to be an important therapeutic target in cancer chemotherapy for the camptothecins as well as for indolocarbazole antibiotics such as BE-13793C and its synthetic derivatives NB-506 and ED-110 [Yoshinari et al. (1993) Cancer Res. 53, 490−494]. To investigate the mechanism of topoisomerase I inhibition by indolocarbazoles, we have studied the induction of DNA cleavage by purified mammalian topoisomerase I mediated by the antitumor antibiotic rebeccamycin and a series ...
Tópico(s): Neutropenia and Cancer Infections
1997 - American Chemical Society | Biochemistry
Jean‐François Goossens, Jean‐Pierre Hénichart, Fabrice Anizon, Michelle Prudhomme, Christophe Dugave, Jean‐François Riou, Christian Bailly,
Tópico(s): DNA Repair Mechanisms
2000 - Elsevier BV | European Journal of Pharmacology
François‐Xavier Nouhaud, Marouene Chakroun, C. Lenormand, I. Ouzaïd, B. Peyronnet, A. Gryn, Thomas Prudhomme, V. Grafeille, M. Soulié, M. Roumiguié, G. Verhoest, Évanguelos Xylinas, A. Bouzouita, Mohamed Chébil, Christian Pfister,
To assess whether progressive and primary muscle invasive bladder cancer (MIBC) have different prognosis after radical cystectomy or not. To date only a few data are available on this topic with conflicting results. Further studies on large cohort are needed to clarify these outcomes that may influence bladder cancer management for these patients. A multicentre retrospective study was conducted on patient treated for MIBC at 5 centres between 2005 and 2015 by radical cystectomy. Patients' outcomes ...
Tópico(s): Urological Disorders and Treatments
2020 - Elsevier BV | Urologic Oncology Seminars and Original Investigations