Cosme Landesman, Jonathan Northcroft, Waldemar Januszczak, Richard Clayton, Hala Jaber, John Dugdale, William Kay, David Modell, Barbara Hall, Aminatta Forna, Tony Barrell, John-Paul Flintoff, Don Cairns, Jim Munro, David Mills, Helen Davies, Sally Brock, Rob Hughes, Jim Connolly, John Peter, Les Worrall, Andrew Longmore, Lesley White, Chris Goater, Christopher Somerville, Ivo Tenast, Frank Whitford, Barry Elsom, Chris Oxborrow, Sophie Kinsella, Nicolette Jones, Caroline Brannigan, David Gower, Sam Gilpin, Kathryn Cooper, Sybil Kapoor, Michael Pauls, Raymond Hendry, David Smith, Richard Hoskins, Louise Armiststead, Nick Pitt, Stephanie Theobald, Richard Green, Ali Rifat Bathdad, Andrew Sullivan, Clive Davis, John Gillingham, John Aiziewood Aiziewood, Richard Lines, Mathew Campbell, John Torpey, Andrew Porter, Malcolm Rough, Joseph Dunn, Dominic Bradbury, Martin James, Simon Wilde, Gemma Scott-Martin, Robert Sandall, Tom Walker, Anthony Sattin, Colin McdoweLL'S, Robert Winnett, Thomas Johansson, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Sean Fitzpatrick, Peter Wilson, Rosie Millard, Angela Thompson, David Dougill, John Arlidge, Brendan O'Neill, Emma John, John Bryant, Stuart Barnes, Richard Retcher, Peter Jones, Chris Hastan, Phnom Penh, Rob Maul, Alistair Weaver, Cally Law, Will Smith, Elizabeth Scott-Baumann, Paul Forsyth, Gavin Sverdloff, Hugh Canning, Jeremy Clarkson, Michael Dowling, Jack Hamilton, Phil Spencer, Edward Porter, Nicola Smith, Victoria Segal, David Cairns, Marie Campbell, Sarah Dempster, Dave Pollard, David Smith Economic Editor, Daryl Hannah, Richard Fletcher, Janet Hanlon, S Craig, David Eimer, Daley Thompson, Adair Turner, James Delingpole, Jeremy Taylor, Andrew Porter Deputy Political Editor, Brendan Bourne, David Walsh Chief Sports Writer, Rev Andrew de Berry, Robin Scott-Elliot, Stuart Wavell, Sarah-Kate Templeton, Roger Eglin, Richard Bennett, David Herson, Paul Donovan, Mary Beard, Christopher Silvester, Maggie Gee, Professor Gideon Gorter, Paul Kimmage, Giles Hattersley, Hugh McIlvanney, Chris Woodhead, Peter Glover, Steve Boyd, Alive Leve, Jasper Gerard, Paul Driver, John Follain, Richard Brooks, Shelley Von Strunckel, Stuart Andrews, Rod Craig, Christopher Morgan, David Leppard, Paul Durman, Mark Edwards, Mike Morgano, Rachel Bridge, Susan Clark, Jung Chang, Garbhan Downey, Nell Wormald, Blower, Phil Baker, Christine Maxwell, Allen Ginsberg, Raymond Keene, Gareth Huw Davies, W Ewing, Rod Liddle, John Brown, Stanley Stewart, Cosmo Landesman, Zoe Brennan, Peter Hall, Marie Colvin, Roland Brown, Jane Massey, Emma Smith, Alice Douglas, Stephen Jones, Dominic O'Connell, Barry Flatman, Uzi Mahnaimi, Louise Armitstead, Natalie Graham, Jonathan Palethope, Spindle, Caroline Donald, Rob Ryan, Christiane Amory, Ian Critchley, David Walsh, Trevor Lewis, Talib Choudhry, Bryan Appleyard, Richard Rac, Stephen Armstrong, John Elliott, Shena Humphreys, Christopher Goodwin, Chris Greenwell, Mark Anstead, Bethan Cole, R W Johnson, Victoria O'brien, Chrictine Toomey, Roland White, Adam Bellow, Shane Watson, Abul Taher, Andy Williams, Amrit Dhillon, Maurice Chittenden, Tom Cox, Richard Brooks Arts Editor, Pete Spencer, Richard Rae, Jon Ungoed-Thomas, Dr Gren Ireson Loughborough University, Louise Armistead, Bono, Doug George, Claire Robinson, Michael Sheridan, Negel Powell, David Parry-Jones, Clare Francis, Michael Smith, John Harlow, Chris Haslam, Mark Kleinman, John Waples, Brian Hunt, Peter Rushforth, Jeremy Hart, A A Gill, Micheal Burleigh, Peter O'Reilly, Matthew Campbell, Jack Hamilton Sofia, John Carey, Enda Leahy, David Horspool, David Sumner Smith, Mary Braid, Nick Fielding, Simon Jenkins, Fearme Cotton, Stephen Pettitt, Will Iredale, Jessica Bown, John Spurling, Victor Bryant, Justin Sparks, Sally Kinnes, Glenda Brett-Holt, Tom Pattinson, Daniel Emery, Mrs P M B, David Wickers, Steve Sheard, Roger Dobson, Dora Bryan, Brian Doogan, Simon Buckland, Minette Marrin, John Aizlewood, Jeremy Lazell, Clifford Bishop, Simon Kurs, Andrew Frankel, Graham Norwood, Jonathan Futrell, Heather Lima, John Guy, John Samuels, Lesley Parsons, David Budworth, Ryder Ascott, John Charool, Hugh Pearman, Dan Cairns, Alan Stewart, Stewart Mitchell, Nick Foulkes, David Smith Economics Editor, Rachel De Thame, Cary Cooper, Prince William, Emma Forrest, Sarah Baxter, Brian Schofield, Mat Loup, Matthew Goodman, Kate Spicer, Sara Hassan, Victoria Stanley, Jon Bennett, Simon Howard, Tom Holland, Jason Dawe, Karen Robinson, Helen Stewart,
Contents New plan for drivers to pay £1.30 a mile London umbrella assassin is named Contents Lloyds TSB Business Contents Blair faces EU budget ambush ...
2005 - Gale Group | Sunday Times HA GDA
Andrew Brown, Juan Fernández‐Tajes, Mun‐Gwan Hong, Caroline Brorsson, Robert W. Koivula, David Davtian, Théo Dupuis, Ambra Sartori, Theodora-Dafni Michalettou, Ian Forgie, Jonathan Adam, Kristine H. Allin, Robert Caïazzo, Henna Cederberg, Federico De Masi, Petra J. M. Elders, Giuseppe N. Giordano, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Alison Heggie, Cédric Howald, Angus G. Jones, Tarja Kokkola, Markku Laakso, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Donna McEvoy, Miranda Mourby, Petra B. Musholt, Birgitte Nilsson, François Pattou, Deborah Penet, Violeta Raverdy, Martin Ridderstråle, Luciana Romano, Femke Rutters, Sapna Sharma, Harriet Teare, Leen M. ‘t Hart, Konstantinos D. Tsirigos, Jagadish Vangipurapu, Henrik Vestergaard, Søren Brunak, Paul W. Franks, Gary Frost, Harald Grallert, Bernd Jablonka, Mark I. McCarthy, Imre Pávó, Oluf Pedersen, Hartmut Ruetten, Mark Walker, Kofi P. Adragni, Rosa Lundbye Allesøe, Anna A. Artati, Manimozhiyan Arumugam, Naeimeh Atabaki‐Pasdar, Tania Baltauss, Karina Banasik, Anna Barnett, Patrick Baum, Jimmy D. Bell, Joline W. J. Beulens, Susanna Bianzano, Roberto Bizzotto, Amélie Bonnefond, Louise Cabrelli, Matilda Dale, Adem Y. Dawed, Nathalie de Préville, Koen F. Dekkers, Harshal Deshmukh, Christiane Dings, Louise A. Donnelly, Avirup Dutta, Beate Ehrhardt, Line Engelbrechtsen, Rebeca Eriksen, Yong Fan, Jorge Ferrer, Hugo Fitipaldi, Annemette Forman, Andreas Fritsche, Philippe Froguel, Johann Gassenhuber, Stephen Gough, Ulrike Graefe‐Mody, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Guðmundsdóttir, Ramneek Gupta, Anita M. Hennige, Anita Hill, Reinhard W. Holl, Michelle Hudson, Ulrik Plesner Jacobsen, Christopher Jennison, Joachim Johansen, Anna Jonsson, Tugce Karaderi, Jane Kaye, Gwen Kennedy, Maria Klintenberg, Teemu Kuulasmaa, Thorsten Lehr, Heather Loftus, Agnete Troen Lundgaard, Gianluca Mazzoni, Nicky McRobert, Ian McVittie, Rachel Nice, Claudia Nicolay, Giel Nijpels, Nicholette D. Palmer, Helle K. Pedersen, Mandy H. Perry, Hugo Pomares‐Millan, Cornelia Prehn, Anna Ramisch, Simon Rasmussen, Neil Robertson, Marianne Rodriquez, Peter Sáckett, Nina Scherer, Nisha Shah, Iryna Sihinevich, Roderick C. Slieker, Nadja B. Søndertoft, Birgit Steckel-Hamann, Melissa K. Thomas, Cecilia Engel Thomas, E. Louise Thomas, Barbara Thorand, Claire E. Thorne, J. Tillner, Andrea Tura, Mathias Uhlén, Nienke van Leeuwen, Sabine van Oort, Hélène Verkindt, Josef Korbinian Vogt, Peter Wad Sackett, Agata Wesolowska‐Andersen, Brandon Whitcher, Margaret W. White, Jerzy Adamski, Jochen M. Schwenk, Ewan R. Pearson, Emmanouil T. Dermitzakis, Ana Viñuela,
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic regulation is detected between gene expression and proteins (66.6%), with a further median shared genetic ...
Tópico(s): Bioinformatics and Genomic Networks
2023 - Nature Portfolio | Nature Communications
Susan CLARk, Waldemar Januszczak, Matthew Wall, Barbara Hall, Christopher Morgan Religious Affairs Correspondent, Maurice Parkinson, Philip Norman, Sir Michael Rose, Jim Munro, John Peter, Emma Moore, Amanda Ursell, Allan Grove, Mirjiana Lucic, John Jay, Sharon Adams, Susan d'Arcy, Frank Whitford, Ravi Shastri, Ivo Tennant, Ferdinand Mount, Sally O'Reilly, David Smith, Kirstie Hamilton City Editor, Humphrey Carpenter, Paul Driver, Chris Dignan, Melanie Phillips, Nick Pitt, Neil Wormald, Clive Davis, Keith Markland, P Swann, Stephen Grey, Mary Wilson, Dr Roger Henderson, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, Anthony Sattin, Alison Brace, Robert Winnett, Neill Buckley, Irwin Stelzer, Tom English, Peter Wilson, Roger Anderson, Angela Mollard, Marian Phillips, Pat Rowley, David Dougill, John Evans, Philip Kingsley, Thrasy Petropoulos, H C, Sarah Toyne, David Hewson, Marian Martin, Tania Alexander, Paul Caplin, Margaret Coles, Hugh Canning, Margarette Driscoll, Louise Potterton, Peter Watson, Graham Duffill, Jeremy Clarkson, Nigel Williams, Peter Conradi, John Richmond, John Waples Deputy City Editor, Edward Porter, Stewart Lee, Eben Black, Anita Chaudhuri, Nick Newman's, Dr Marek Czajkowski, Peter Millar, Paul Donavan, Robin Marlar, Jack Warnette, Anita Brookner, Nick Gardner, Geoffrey Wheatcroft, A F G, Royal Ascot, Mike Laws, Phillip Oppenheim, Jonathan Abel, Guy Richards, Josephine Smit, Paul Donovan, A J Kirk, Steve Waugh, Vera Taggart, Mike Levett's, Bob Woodward, Sue Lawrence, Simon Mills, Justin Cartwright, J Cree, Roger Scruton, Derek Clements, Michael Woodhead, Garth Pearce, Wimbledon babes, David Thomas, Nicholas Hellen, Richard Brooks, Peter Windsor, Steven Downes, Ian Hawkey, Shelley Von Strunckel, Ann McFerran, Mrs N S, Tim Rayment, A T, Joel Stern, Alicia Wyllie, Richard Girling, Mark Edwards, Steve Farrar Science Correspondent, Elina Hesso, Reginald Dale, Kirstie Hamilton, Victoria Campbell King, Tom Shone, Stephen Amidon, David Lawrenson, Nicholas Rufford Home Affairs Editor, Phil Baker, Andrew Motion, Frank Porter, Sean Newsom, Bob Graham, Michael Ignatieff, Raymond Keene, Chris Oliver Wilson, Barbara Schwartz, Douglas Alexander, Stanley Stewart, Cosmo Landesman, Marie Colvin, Diana Wright, Geoffrey Mason, Kipper Williams, F Gill, Vincent Cartwright, Helen Hawkins, Michael Prescott Political Editor, Stephen Jones, Richard Evans, Nick Cain, Peta Bee, Natalie Graham, Paul Nuki, Roger Browne, Dr Philip Peverley, Claire Oldfield, Miranda Seymour, David Walsh, Robert Weir, L Collingwood, Zoë Linkson, John Stern, T S, Lois Rogers Medical Correspondent, David Mason, Michael Bradley, Josh Salzmann, David Franklin, John B Reddington, Roland White, Garth Alexander, Donald Edmonds, Jessica Berry, Maurice Chittenden, Alex Fortune, Kevin Pratt, Ivan Massow, Michael Bennett, Andrew Lorenz Business Editor, Judith O'Reilly, Mark Franchetti, Ann Blatcher, Rupert Gavin, Jon Ungoed-Thomas, Jonathan Powell, Ray Hutton, B Coleman, Tara Palmer-Tomkinson, Marc Doyle, Michael Sheridan, Roy Aspen, Sean Hargrave, Christine Webb, D J Taylor, Brian Smyth, Matthew Lynn, Richard O'Neill, Michael Austin, Graham Hearne, Godfrey Smith, Rosalind Coward, John Waples, Brian Bigmore, Terry Murden, A A Gill, Matthew Campbell, Brian Glanville, Sir Christopher Bland Chairman, Tom Robbins, Noel Winter, David Sumner Smith, Robert Johnston, Chrissy Iley, Stephen Pettitt, Andrew Lorenz, Naomi Caine, David Wickers, Tom Rhodes, Christine Ross, Nicholas Hellen Media Correspondent, Christina Jones, Rupert Steiner, Hugh Pearman, Dan Cairns, Kat Brown, William Moss, Tony Perrottet, David Parsley, Jamie Oliver, Derck Mahon, J H, David Smith Economics Editor, Penny Perrick, Mikhail Baryshnikov, Robert Sam Anson, Amanda Hines, Joanna Simon, Michael Dixon, India Knight, Sandy Gall, Simon Howard, W B Yeats, Dan Pearson, Joan Smith, Boris Schapiro, Tim Bullamore,
... Heinz Holliger, Maurice Bourgue (oboes), Klaus Thunemann (bassoon), Christiane Jacottet (harpsichord), Thomas Zehetmair (violin), Klaus Stoll (double ...
1999 - Gale Group | Sunday Times HA GDA
Roberto Bizzotto, Christopher Jennison, Angus G. Jones, Azra Kurbasic, Andrea Tura, Gwen Kennedy, Jimmy D. Bell, E. Louise Thomas, Gary Frost, Rebeca Eriksen, Robert W. Koivula, Søren Brage, Jane Kaye, Andrew T. Hattersley, Alison Heggie, Donna McEvoy, Leen M. ‘t Hart, Joline W. J. Beulens, Petra Elders, Petra Musholt, Martin Ridderstråle, Tue H. Hansen, Kristine H. Allin, Torben Hansen, Henrik Vestergaard, Agnete Troen Lundgaard, Henrik S. Thomsen, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Ian M. Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Emmanouil T. Dermitzakis, Mark I. McCarthy, Oluf Pedersen, Jochen M. Schwenk, Jerzy Adamski, Paul W. Franks, Mark Walker, Ewan R. Pearson, Andrea Mari, Moustafa Abdalla, Jonathan Adam, Jerzy Adamski, Kofi Adragni, Rosa Lundbye Allesøe, Kristine H. Allin, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Karina Banasik, Patrick Baum, Jimmy D. Bell, Margit Bergstrom, Joline W. J. Beulens, Susanna Bianzano, Roberto Bizzotto, Amelie Bonneford, Caroline Brorsson, Andrew Brown, Søren Brunak, Louise Cabrelli, Robert Caïazzo, Mickaël Canouil, Matilda Dale, David Davtian, Adem Y. Dawed, Federico De Masi, Nathalie de Préville, Koen F. Dekkers, Emmanouil T. Dermitzakis, Harshal Deshmukh, Christiane Dings, Louise A. Donnelly, Avirup Dutta, Beate Ehrhardt, Petra Elders, Line Engelbrechtsen, Rebeca Eriksen, Juan Fernandez, Jorge Ferrer, Hugo Fitipaldi, Ian M. Forgie, Annemette Forman, Paul W. Franks, Francesca Frau, Andreas Fritsche, Philippe Froguel, Gary Frost, Johann Gassenhuber, Nick N. Giordano, Toni Giorgino, Stephen Gough, Ulrike Graefe‐Mody, Harald Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Guðmundsdóttir, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna S. Häussler, Alison Heggie, Anita M. Hennige, Anita Hill, Reinhard W. Holl, Mun‐Gwan Hong, Michelle Hudson, Bernd Jablonka, Christopher Jennison, Yunlong Jiao, Joachim Johansen, Angus G. Jones, Anna Jonsson, Tugce Karaderi, Jane Kaye, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D.M. Koopman, Azra Kurbasic, Teemu Kuulasmaa, Markku Laakso, Thorsten Lehr, Heather Loftus, Agnete Troen Lundgaard, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donna McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, Petra Musholt, Pascal M. Mutie, Rachel Nice, Claudia Nicolay, Agnes Martine Nielsen, Birgitte Nilsson, Nicholette D. Palmer, François Pattou, Imre Pavo, Ewan R. Pearson, Helle K. Pedersen, Oluf Pedersen, Mandy H. Perry, Hugo Pomares‐Millan, Simon Rasmussen, Violeta Raverdy, Martin Ridderstråle, Neil Robertson, Slieker Roderick, Marianne Rodriquez, Hartmut Ruetten, Femke Rutters, Peter Wad Sackett, Nina Scherer, Jochen M. Schwenk, Nisha Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Søndertoft, Hans-Henrik Staerfeldt, Birgit Steckel-Hamann, Leen M. t Hart, Harriet Teare, Cecilia Engel Thomas, Melissa K. Thomas, E. Louise Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, J. Tillner, Martina Troll, Konstantinos D. Tsirigos, Andrea Tura, Mathias Uhlén, Nienke van Leeuwen, Hélène Verkindt, Henrik Vestergaard, Ana Viñuela, Josef Korbinian Vogt, Dianne Wake, Mark Walker, Agata Wesolowska‐Andersen, Brandon Whitcher, Han Wu,
OBJECTIVE We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) study were extensively phenotyped over 3 years, including measures of insulin sensitivity (OGIS), β-cell glucose sensitivity (GS), and insulin clearance (CLIm) from mixed meal tests, liver enzymes, lipid profiles, and baseline ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2020 - American Diabetes Association | Diabetes Care
By Our Foreign Staff, By Peter Hill, Industrial Editor, By Frances Gibb, David Walker, By Philip Webster, Political Reporter, By Hazhir Teimourian, From Ronald Kershaw, From Richard Ford, By Paul Routledge, Labour Editor, By Lorna Bourke, From Our Correspondent, By Tony Samstag, By Nicholas Timmins, By David Blake Economics Editor, By Hugh Clayton Environment Correspondent, By Ronald Faux, By Diana Geddes, Education Correspondent, From John Young, Agriculture Correspondent, , By Robin Young, Consumer Affairs Correspondent, By Pat Healy, Social Services Correspondent, From Our Correspondent, , By Annabel Ferriman, Health Services Correspondent, By David Walker, From Harry Golombek Chess Correspondent, By a Staff Reporter, By Lucy Hodges, From George Clark, , From Charles Hargrove, , From Douglas Aiton, , From Our Own Correspondent, From David Blow, , From Michael Hamlyn, From Ian Murray, , From Nicholas Ashford, From Robert Fisk, , From Godfrey Morrison, , From Michael knipe, , From Ross Waby, , From Michael Hamyln, By Robin Young, Simon Scott-Plummer, From Bailey Morris, From Nicholas Ashford, , From Dessa Trevisan, , From Michael Hornsby, , From Clive Cookson, From David Watts, Michael Ratcliffe, Stanley Sadie, David Robinson, Paul Griffiths, Noel Goodwin, Irving Wardle, Ned Chaillet, Richard William, David Watt, Martin Gilbert, Peter Watson, by Bill Keys, HARRY GREENWAY., WYNNE GODLEY, , DAVID MASON, , FRANK OTHICK., JOHN LYONS, , ANTONI POSPIESZALSKI, , NIGEL LINACRE, , JAMES JARDINE, , GEOFFREY WILSON, , HAROLD ROSENTHAL, , JOAN KING-FARLOW, , JOANNE BOWER, , From Our Parliamentary Correspondent, Miles Kington, By Kenneth Gosling, By Geraldine Norman Sale Room Correspondent, The Principal of King's College, London, writes:, By Peter Hill Industrial Editor, By Clifford Webb, By David Blake, Economics Editor, By Melvyn Westlake, By Baron Phillips, By John Whitmore, By David Hewson, By Philip Robinson, By Bill Johnstone, By Our Industrial Editor, by Clive Cookson, BY THE FINANCIAL EDITOR, Ross Davies, Melvyn Westlake, Peter Wilson-Smith, By Our Financial Staff, By Paul Maidment, By Drew Johnston, Hunter Davies, From John Ballantine, By Stuart Jones Football Correspondent, By Roy McKelvie, From Richard Streeton, By Peter West, Steve Elliott, By Srikumar Sen Boxing Correspondent, Michael Phillips Racing Correspondent, By a Special Correspondent, By Iain Mackenzie, by Peter Waymark, Edited by Peter Dear, Frank Johnson, Louise Nicholson, Christopher Warman, Judy Froshaug, Derek Winnert, Geoff Brown, Peter Davalle, David Wade, Geoffrey Wansell, Richard Williams, David Hewson, William Mann, John Higgins, John Percival, Mel Lewis, John Russell Taylor, Michael Young, Sue Bond, Nicholas Keith, Stuart Jones, Michael Seely, Philippa Toomey, Eleanor Bloom,
... Alternative Theatre, Drink Link, Birzeit University, Dewar's, Christiane F., LV, Royal Festival Hall, Certina Swiss Watches, ...
1981 - Gale Group | TDA
Adem Y. Dawed, Andrea Mari, Andrew Brown, Timothy J. McDonald, Lin Li, Shuaicheng Wang, Mun‐Gwan Hong, Sapna Sharma, Neil R. Robertson, Anubha Mahajan, Xuan Wang, Mark Walker, Stephen Gough, Leen M. ‘t Hart, Kaixin Zhou, Ian Forgie, Hartmut Ruetten, Imre Pávó, Pallav Bhatnagar, Angus G. Jones, Ewan R. Pearson, Leen M. ‘t Hart, Mohamed Elhassan Abdalla, Jean‐Michel Adam, J. Adamski, Kofi P. Adragni, Kristine H. Allin, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Kamil Banasik, Patrick Baum, Jimmy D. Bell, Mats Bergström, Joline W. J. Beulens, Susaana Bianzano, Roberto Bizzotto, Amelie Bonneford, Caroline Brorsson, A.A. Brown, S.B. Brunak, Louise Cabrelli, Robert Caïazzo, Mickaël Canouil, M.M. Dale, David Davtian, Adem Y. Dawed, F.M. De Masi, Nathalie de Préville, Koen F. Dekkers, E. T. Dermitzakis, Harshal Deshmukh, Christiane Dings, Louise Donnelly, Avirup Dutta, Beate Ehrhardt, Petra J. M. Elders, Cecilia Engel Thomas, Line Engelbrechtsen, R.G. Eriksen, R.E. Eriksen, Yong Fan, J. Fernandez, José Illnait Ferrer, Hugo Fitipaldi, Ian Forgie, Axel Forman, Paul W. Franks, Franco Frau, A. Fritsche, P. Froguel, Gary Frost, Johann Gassenhuber, Guillermo Giordano, Toni Giorgino, Stephen Gough, Ulrike Graefe‐Mody, H. Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, V Gudmundsdottir, R.G. Gupta, Mark Haid, T. Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna S. Häussler, A.J. Heggie, Anita M. Hennige, Adrian V. S. Hill, Reinhard W. Holl, Mun‐Gwan Hong, Michelle Hudson, Bernd Jablonka, Christopher Jennison, Jian Jiao, Jon Johansen, Adam G. Jones, A. Jonsson, Tugce Karaderi, Jane Kaye, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D.M. Koopman, A Kurbasic, T. Kuulasmaa, M. Laakso, Thorsten Lehr, Hannah Loftus, R.L.A Lundbye Allesøe, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donald McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, PB Musholt, Pascal M. Mutie, Rachel Nice, Claudia Nicolay, Agnes Martine Nielsen, Birgitte Nilsson, Nicholette D. Palmer, François Pattou, Imre Pávó, Ewan R. Pearson, Oluf Pedersen, Helle K. Pedersen, Mandy H. Perry, Hugo Pomares‐Millan, Anna Ramisch, Sebastian Buhl Rasmussen, V. Raverdi, Martin Ridderstråle, N. Robertson, Ryland Roderick, M. Rodriquez, Hartmut Ruetten, Femke Rutters, Walter G. Sackett, N. Scherer, Jochen M. Schwenk, N. Jon Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Søndertoft, Hans‐Henrik Stærfeldt, Birgit Steckel-Hamann, Harriet Teare, Melissa K. Thomas, E. Louise Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, J. Tillner, A.T.L. Troen Lundgaard, Mark Troll, Kostas Tsirigos, Andrea Tura, Mathias Uhlén, Nienke van Leeuwen, Sabine van Oort, Hélène Verkindt, Henrik Vestergaard, A. Viñuela, Josef Korbinian Vogt, P.W.S Wad Sackett, Deborah J. Wake, Mark Walker, Agata Wesolowska‐Andersen, Brandon Whitcher, Matthew White, Han Wu,
In the treatment of type 2 diabetes, GLP-1 receptor agonists lower blood glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and side effects of GLP-1 receptor agonists vary between people. Human pharmacogenomic studies of this inter-individual variation can provide both biological insight into drug action and provide biomarkers to inform clinical decision making. We therefore aimed to identify genetic variants associated with glycaemic response to GLP-1 receptor ...
Tópico(s): Genetic Associations and Epidemiology
2022 - Elsevier BV | The Lancet Diabetes & Endocrinology
Srikumar Sen, Boxing Correspondent, Phil Yates, Janty Jones, Robert Cole and Matthew Barbour, Tunku Varadarajan, Jon Ashworth, Matthew Wall, Raymond Snoddy Media Editor, Noreen Taylor, Andrew Pierce, Political Correspondent, Paul Heiney, Alasdair Riley, Fred Mawer, Andrew Eames, Joanna Hunter, S. B. Tress, Brian Greer, Alexandra Frean, Kathy Lipari, Sam Kiley Africa Correspondent, Jane MacQuitty, Simon Barnes, Derek Clarkson, Magnus Linklater, John Morgan, Paul Hoggart, Tim Burden, R. Morsely Smith, Richard Hobson, Karen Woolfson, Arachne, Ivo Tennant, T. P, Andrew Robinson, Philip Delves, Raymond Snoddy, Media Editor, Philip Howard, Janet Bush Economics Editor, Michaele Martin, Stephen Levinson, W. S. C., Jeremy Kingston, Patrick Collinson, James Bone, Edward Welsh, Jill Ross, Lynne Truss, Douglas Grubb, Louisa Reid, Simon Wilde, Tony Patrick, Kevin Eason, James Eve, Clare Stewart, Louise Godfrey, Adam Hopkins, Lawrence Dallaglio, Carl Evans, Colin Steel, Madeleine Kingsley, Pat Gibson, Ruth Gledhill, Religion Correspondent, Robert Sheehan, D. R., Steve Keenan, (Ben MacIntyre), amandip uppal, Jean-Christophe Novelli, Dominic Walsh, Ruth Gledhill, Peter Sergeant, Matthew Barbour, Paul Badham, Brain Glanville, E. C., T. C., Martin Barrow, Sidney Brichto, Richard Ford Home Correspondent, Anthony Quinton, Stephen Farrell, David Dabydeen, Nicholas Roe, Barbara Abbs, T. P., Eve-Ann Prentice, Jane Shelling, Frances Bissell, Mike Bradley, David Hands, P. B., Charles Bremner, Helen Rumbelow, Peter Barnard, Derwent May, David Johnson, Ben Reed, P. Ashford, Cath Urquhart, Robert Cole City Correspondent, Stephen Anderton, Rachel Bridge, Audrey Magee, Ireland Correspondent, John Hopkins Golf Correspondent, Christina Koning, Adam Jones, Simon Veness, Anelka of Arsenal, D. R, Raymond Keene, Des Turner, David Turner, Gareth Huw Davies, David Maddock and Russell Kempson, Judigh Wilson, David Robinson, Matt Dickinson, Karen Zagor, Alix Ramsay, Paul Wilkinson, James Allcock, Kate Stronach, Richard Evans, Min Cooper, J. C. Kelly, Peter Giles Chairman, Robin Neillands, elspeth thompson, Oliver Holt, Rachel Kelly and Alan Hamilton, Roger Boyes, David Rule, David Devore, W. Stephen Gilbert, Adam Fresco, Nicholas Wood, Desmond Hartley, Anne Ashworth, Nick Szczepanik, Jack Crossley, W. S. G., P. C. P., Giles Whittell, Sara McConnell, L. G, Simon De Bruxelles, Jason Nissé, Craig Lord, Philip Webster and Charles Bremner, Mel Webb, Belinda Rhodes, Deborah King, Brian Morgan, Kevin McCarra, Richard Evans Racing Correspondent, Mark Hodkinson, Iain Smith, Chris McGrath, Tim Wapshott, John Shaw, Michael Austin, Jane Owen, Kevin Dowling, Ben MacIntyre, Helen Pridham, Jim Keeble, Paul Barker, Colin Shindler, vinny lee, Brian Glanville, S. M. Drage, Polly Newton Political Reporter, Michael Roffen, David Bowker, Graham Searjeant, John Naish, Fraser Nelson, Simon Jenkins, Steve McManaman, Anne Ashworth Personal Finance Editor, Martin Waller, Michael Horsnell, Gillian Harris, Chris Ayres, Christiane Hildrew, John Hunwicke, Marianne Curphey Insurance Correspondent, Danny Baker, Peter Ingham, Lottie Moggach, Perry Cleveland-Peck, Tom Rhodes, Marianne Curphey, Jill Crawshaw, Stephen Gardiner, Michael Evans Defence Correspondent, David Powell, Jack Bailey, Joe Warwick, Tom Chesshyre, Roger Bush, David Maddock, Audrey Magee Martin Fletcher and Nicholas Watt, Jane Goodkin, Charlie Porter, Penny Perrick, Oliver Bennett, Thomas Stuttaford, Edward Gorman Sailing Correspondent, David Long, David Hands, Rugby Correspondent, Richard Ford, Jim Moyes, Alasdair Murray, Economics Correspondent, Christopher Irvine,
Tories cash in on the countryside marchers Index Mass murderer Gitta Sereny Policeman convicted of sex attacks Titanic star falls for model intellect ...
1998 - Gale Group | TDA
Andrea Tura, Eleonora Grespan, Christian Göbl, Robert W. Koivula, Paul W. Franks, Ewan R. Pearson, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Imre Pávó, Hartmut Ruetten, Emmanouil T. Dermitzakis, Mark I. McCarthy, Oluf Pedersen, Jochen M. Schwenk, Jerzy Adamski, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Jagadish Vangipurapu, Henna Cederberg, Markku Laakso, Femke Rutters, Petra J. M. Elders, Anitra D.M. Koopman, Joline W. J. Beulens, Martin Ridderstråle, Tue H. Hansen, Kristine H. Allin, Torben Hansen, Henrik Vestergaard, Andrea Mari, Leen M. ‘t Hart, Moustafa Abdalla, Jonathan Adam, Jerzy Adamski, Kofi P. Adragni, Rosa Lundbye Allesøe, Kristine H. Allin, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Karina Banasik, Patrick Baum, Jimmy D. Bell, Margit Bergstrom, Joline W. J. Beulens, Susaana Bianzano, Roberto Bizzotto, Amelie Bonneford, Caroline Brorsson, Andrew Brown, Søren Brunak, Louise Cabrelli, Robert Caïazzo, Mickaël Canouil, Henna Cederberg, Matilda Dale, David Davtian, Adem Y. Dawed, Federico De Masi, Nathalie de Préville, Koen F. Dekkers, Emmanouil T. Dermitzakis, Harshal Deshmukh, Christiane Dings, Louise A. Donnelly, Avirup Dutta, Beate Ehrhardt, Petra J. M. Elders, Line Engelbrechtsen, Rebeca Eriksen, Yong Fan, Juan Fernandez, Jorge Ferrer, Hugo Fitipaldi, Ian M. Forgie, Annemette Forman, Paul W. Franks, Francesca Frau, Andreas Fritsche, Philippe Froguel, Gary Frost, Johann Gassenhuber, Giuseppe N. Giordano, Toni Giorgino, Stephen Gough, Ulrike Graefe‐Mody, Harald Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Guðmundsdóttir, Ramneek Gupta, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna S. Häussler, Alison Heggie, Anita M. Hennige, Anita Hill, Reinhard W. Holl, Mun‐Gwan Hong, Michelle Hudson, Bernd Jablonka, Christopher Jennison, Yunlong Jiao, Joachim Johansen, Angus G. Jones, Anna Jonsson, Tugce Karaderi, Jane Kaye, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D.M. Koopman, Azra Kurbasic, Teemu Kuulasmaa, Markku Laakso, Thorsten Lehr, Heather Loftus, Agnete Troen Lundgaard, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donna McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, Petra Musholt, Pascal M. Mutie, Rachel Nice, Claudia Nicolay, Agnes Martine Nielsen, Birgitte Nilsson, Giel Nijpels, Nicholette D. Palmer, François Pattou, Imre Pávó, Ewan R. Pearson, Oluf Pedersen, Helle K. Pedersen, Mandy H. Perry, Hugo Pomares‐Millan, Anna Ramisch, Simon Rasmussen, Violeta Raverdi, Martin Ridderstråle, Neil Robertson, Slieker Roderick, Marianne Rodriquez, Hartmut Ruetten, Femke Rutters, Peter Wad Sackett, Nina Scherer, Jochen M. Schwenk, Nisha Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Søndertoft, Hans‐Henrik Stærfeldt, Birgit Steckel-Hamann, Harriet Teare, Cecilia Engel Thomas, Melissa K. Thomas, E. Louise Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, J. Tillner, Martina Troll, Konstantinos D. Tsirigos, Andrea Tura, Mathias Uhlén, Jagadish Vangipurapu, Nienke van Leeuwen, Sabine van Oort, Hélène Verkindt, Henrik Vestergaard, Ana Viñuela, Josef Korbinian Vogt, Peter Wad Sackett, Dianne Wake, Mark Walker, Agata Wesolowska‐Andersen, Brandon Whitcher, Margaret W. White, Han Wu,
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+ ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2021 - American Diabetes Association | Diabetes
F. Edenborough, G Borgo, Christiane Knoop, Louise Lannefors, W. E. Mackenzie, Susan Madge, Alison Morton, H. Oxley, Daan J. Touw, M. Benham, Magnus Johannesson,
Women with cystic fibrosis (CF) now regularly survive into their reproductive years in good health and wish to have a baby.Many pregnancies have been reported in the literature and it is clear that whilst the outcome for the baby is generally good and some mothers do very well, others find either their CF complicates the pregnancy or is adversely affected by the pregnancy.For some, pregnancy may only become possible after transplantation.Optimal treatment of all aspects of CF needs to be maintained ...
Tópico(s): Breastfeeding Practices and Influences
2007 - Elsevier BV | Journal of Cystic Fibrosis
Sylvie Rocheleau, Charles W. Greer, John R. Lawrence, Christiane Cantin, Louise Laramée, Serge R. Guiot,
ABSTRACT Oligonucleotide probes, designed from genes coding for 16S rRNA, were developed to differentiate Methanosaeta concilii, Methanosarcina barkeri , and mesophilic methanogens. All M. concilii oligonucleotide probes (designated MS1, MS2, and MS5) hybridized specifically with the target DNA, but MS5 was the most specific M. concilii oligonucleotide probe. Methanosarcina barkeri oligonucleotide probes (designated MB1, MB3, and MB4) hybridized with different Methanosarcina species. The MB4 probe specifically ...
Tópico(s): Wastewater Treatment and Nitrogen Removal
1999 - American Society for Microbiology | Applied and Environmental Microbiology
Christiane Gaudreau, Louise A. Lariviere, Jimmy Lauzer, F Turgeon,
The effect of clavulanic acid on the susceptibility of 32 strains of Campylobacter jejuni and Campylobacter coli to eight beta-lactam agents was studied. Almost all strains tested became susceptible to amoxicillin and ticarcillin with 1 microgram of clavulanic acid per ml. This compound had little or no effect on susceptibility to penicillin G, cephalothin, cefamandole, and cefoxitin. Clavulanic acid had a marginal effect on cefotaxime and moxalactam susceptibility.
Tópico(s): Antimicrobial Resistance in Staphylococcus
1987 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Alexandre Siminski, Daisy Christiane Zambiazi, Karine Louise dos Santos, Alfredo Celso Fantini,
This study aimed to understand post-agricultural natural forest regeneration in the Southern Brazilian Atlantic Forest and its possible role as a cost-effective, passive approach to forest restoration. The study characterized vegetation structure, floristic composition, and the dynamics of secondary forest chronosequences. Data were collected from 159 plots (10 × 10 m each) across forest remnants in Santa Catarina State, covering forest ages that ranged from 2 to 60 years of regeneration after swidden ...
Tópico(s): Conservation, Biodiversity, and Resource Management
2021 - Frontiers Media | Frontiers in Forests and Global Change
Elisabeth Njamkepo, Nizar Fawal, Alicia Tran-Dien, Jane Hawkey, Nancy Strockbine, Claire Jenkins, Kaisar A. Talukder, Raymond Bercion, Konstantin V. Kuleshov, R. Kolínská, Julie E. Russell, Л. А. Кафтырева, Marie Accou-Demartin, Andreas Karas, Olivier Vandenberg, Alison E. Mather, Carl J. Mason, Andrew J. Page, Thandavarayan Ramamurthy, Chantal Bizet, Andrzej Gamian, Isabelle Carle, Amy Gassama Sow, Christiane Bouchier, Astrid Louise Wester, Monique Lejay-Collin, Marie‐Christine Fonkoua, Simon Le Hello, Martin J. Blaser, Cecilia Jernberg, Corinne Ruckly, Audrey Mérens, Anne‐Laure Page, Martin Aslett, Peter Roggentin, Angelika Fruth, Érick Denamur, Malabi M. Venkatesan, Hervé Bercovier, Ladaporn Bodhidatta, Chien‐Shun Chiou, Dominique Clermont, Bianca Colonna, S. A. Egorova, Gururaja Perumal Pazhani, Analía V. Ezernitchi, Ghislaine Guigon, Simon R. Harris, Hidemasa Izumiya, Agnieszka Korzeniowska‐Kowal, Anna Lutyńska, Malika Gouali, Francine Grimont, Céline Langendorf, Monika Marejková, Lorea Peterson, Guillermo I. Pérez‐Pérez, Antoinette Ngandjio, А. Т. Подколзин, Erika Souche, М. А. Макарова, German A. Shipulin, Changyun Ye, Helena Žemličková, M Herpay, Patrick A. D. Grimont, Julian Parkhill, Philippe Sansonetti, Kathryn E. Holt, Sylvain Brisse, Nicholas R. Thomson, François‐Xavier Weill,
Together with plague, smallpox and typhus, epidemics of dysentery have been a major scourge of human populations for centuries1. A previous genomic study concluded that Shigella dysenteriae type 1 (Sd1), the epidemic dysentery bacillus, emerged and spread worldwide after the First World War, with no clear pattern of transmission2. This is not consistent with the massive cyclic dysentery epidemics reported in Europe during the eighteenth and nineteenth centuries1,3,4 and the first isolation of Sd1 ...
Tópico(s): Yersinia bacterium, plague, ectoparasites research
2016 - Nature Portfolio | Nature Microbiology
Nigel Rollins, Kirsty Little, Similo Mzolo, Christiane Horwood, Marie‐Louise Newell,
Background: Surveillance programmes for prevention of mother-to-child transmission of HIV (PMTCT) fail to quantify numbers of infant HIV infections averted, often because of poor postnatal follow-up. Additionally, infected infants are often not identified early and only gain access to comprehensive HIV care and treatment late in their disease. Methods: Anonymous, unlinked, HIV prevalence testing was conducted on dried blood spot (DBS) samples from all infants attending 6 week immunization clinics ...
Tópico(s): HIV, Drug Use, Sexual Risk
2007 - Lippincott Williams & Wilkins | AIDS
Carla Nacif-Coelho, Christiane Corréa-Sales, Louise Lenoir Chang, Mervyn Maze,
The alpha 2-adrenergic agonists are members of a novel class of hypnotic-anesthetic agents that selectively bind to alpha 2 adrenoceptors in the locus coeruleus (LC) to initiate their pharmacologic action. The postreceptor molecular mechanism of the hypnotic action of alpha 2-adrenergic agonists remains unknown. In this study we addressed the role of conductance through a variety of calcium and potassium ion channels in the hypnotic action of dexmedetomidine in the LC of the rat.Cannulas were inserted ...
Tópico(s): Sleep and Wakefulness Research
1994 - Lippincott Williams & Wilkins | Anesthesiology
Christiane Zweier, Cornelia Kraus, Louise Brueton, Trevor Cole, Franziska Degenhardt, Hartmut Engels, Gabriele Gillessen‐Kaesbach, Luitgard Graul‐Neumann, Denise Horn, Juliane Hoyer, Walter Just, Anita Rauch, André Reis, Bernd Wollnik, Michael Zeschnigk, Hermann‐Josef Lüdecke, Dagmar Wieczorek,
Borjeson-Forssman-Lehmann syndrome (BFLS) is an X-linked recessive intellectual disability (ID) disorder caused by mutations in the PHF6 gene and characterised by variable cognitive impairment, a distinct facial gestalt, obesity, and hypogonadism. Female carriers are usually not affected or only mildly affected, and so far only two females with de novo mutations or deletions in PHF6 have been reported.We performed PHF6 mutational analysis and screening for intragenic deletions and duplications by ...
Tópico(s): Genomics and Chromatin Dynamics
2013 - BMJ | Journal of Medical Genetics
Christiane Gaudreau, Yves Girouard, Louise Ringuette, Catherine Tsimiklis,
Disk diffusion was a reliable, easy, and inexpensive method for testing the susceptibility of Campylobacter jejuni to erythromycin (215 susceptible and 45 resistant isolates) and to ciprofloxacin (154 susceptible, two intermediate, and 124 resistant isolates) using, respectively, an erythromycin disk and ciprofloxacin and nalidixic acid disks.
Tópico(s): Veterinary medicine and infectious diseases
2007 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Nathalie Lachance, Christiane Gaudreau, F Lamothe, Louise A. Lariviere,
We studied the role of the beta-lactamase of Campylobacter jejuni in resistance to beta-lactam agents. beta-Lactamase-positive strains were more resistant than beta-lactamase-negative strains to amoxicillin, ampicillin, and ticarcillin (P less than 0.05). With penicillin G, piperacillin, imipenem, and six cephalosporins, the susceptibility levels were similar for both beta-lactamase-positive and -negative strains. By using spectrophotometric and microbiological assays, the beta-lactamase from three ...
Tópico(s): Vibrio bacteria research studies
1991 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Seymour Heisler, Laurence Chauvelot, Diane Desjardins, Christiane Noel, Herman Lambert, Louise Desy-Audet,
Many calcium-mediated effects in mammalian cells may be activated by calcium-calmodulin stimulated enzymes. These effects are inhibited by various antidepressant drugs which bind to and inactivate calmodulin. In the current study, calmodulin was identified by affinity chromatography and gel electrophoresis in the cytoplasm of dispersed rat pancreatic acinar cells. Its role in enzyme secretion was assessed by evaluating the effects of various antidepressant drugs on the enzyme secretory process. ...
Tópico(s): Drug Transport and Resistance Mechanisms
1981 - NRC Research Press | Canadian Journal of Physiology and Pharmacology
Albert Adam, Nicole Gervais, A. Panoyan, Huy Ong, Louise Béliveau, Christiane Ayotte, Philippe Delahaut,
Sixty rats were grown in the presence of 10 (n = 30) and 100 (n = 30) micrograms kg-1 body mass of clenbuterol for a period of 10 d. An immunoextraction step coupled with a competitive enzyme immunoassay allowed the quantification of clenbuterol in hair upon 20 (10 micrograms kg-1) and 30 d (10 micrograms kg-1) after the last dose. This accumulation in hair contrasts with the rapid clearance in tissues. The nature of the immunoreactive material was confirmed by mass spectrometry.
Tópico(s): Mass Spectrometry Techniques and Applications
1994 - Royal Society of Chemistry | The Analyst
Sybil P. Seitzinger, Owen Gaffney, Guy Brasseur, Wendy Broadgate, Phillipe Ciais, Martin Claußen, Jan Willem Erisman, Thorsten Kiefer, Christiane Lancelot, P. S. Monks, Karen Louise Smyth, James P. M. Syvitski, Mitsuo Uematsu,
The maturing of Earth system science as a discipline has underpinned the development of concepts such as the Anthropocene and planetary boundaries. The International Geosphere–Biosphere Programme's (IGBP) scientific and institutional history is deeply intertwined with the development of the concept of the Earth as a system as well as the discipline of Earth system science. Here we frame the broader programme of IGBP through its core projects and programme-level activities and illustrate this co-evolution. ...
Tópico(s): Earth Systems and Cosmic Evolution
2015 - Elsevier BV | Anthropocene
Gustav Steinhoff, Xiaomang You, Christiane Steinm ller, Dirk Bauer, Marie-Louise Lohmann-Matthes, Cathrien A. Bruggeman, Axel Haverich,
A possible mechanism of the induction of lung transplant rejection by cytomegalovirus (CMV) infection is the inflammatory upregulation of adhesion ligand molecules on transplant endothelia by the viral infection leading to leukocyte activation. To study this question a rat model of rat cytomegalovirus (RCMV) infection and acute lung transplant rejection was established to study: (1) the influence of RCMV infection on the course of rejection, (2) the influence of rejection on the course of RCMV infection, ...
Tópico(s): Immune Response and Inflammation
1996 - Wolters Kluwer | Transplantation
Sandrine Vuillaumier‐Barrot, C. Bouchet-Séraphin, M. Chelbi, A. Eude-Caye, E. Charluteau, Caroline Besson, Samuel Quentin, Louise Devisme, Christiane Le Bizec, P. Landrieu, Anna Goldenberg, Kim Maincent, Philippe Loget, Odile Boute, Brigitte Gilbert‐Dussardier, Férechté Encha‐Razavi, M. Gonzalés, Bernard Grandchamp, Nathalie Seta,
Dystroglycanopathies are a heterogeneous group of muscular dystrophies with autosomal recessive inheritance characterized by abnormal glycosylation of alpha-dystroglycan. The most severe phenotypes are Walker-Warburg Syndrome (WWS) and muscle-eye-brain disease (MEB) presenting with lissencephaly type II (LIS II) and in which muscular dystrophy is associated with mental retardation and eye abnormalities. To date, six distinct genes, POMT1, POMT2, POMGNT1, FKTN, FKRP, LARGE and recently in one case DPM3, ...
Tópico(s): RNA Research and Splicing
2011 - Elsevier BV | Neuromuscular Disorders
Christiane Yoakim, Pierre Bonneau, Robert Déziel, Louise Doyon, Jianmin Duan, Ingrid Guse, Serge Landry, Éric Malenfant, Julie Naud, William W. Ogilvie, J O'Meara, Raymond Plante, Bruno Simoneau, Bounkham Thavonekham, Michael Bös, Michael G. Cordingley,
A series of 8-heteroarylthiomethyldipyridodiazepinone derivatives were prepared and evaluated for their antiviral profile against wild type virus and the important K103N/Y181C mutant as an indicator for broad activity. 2,6-Dimethylpyridine derivative 16 was found to have a good pharmacokinetic profile in spite of poor metabolic stability in rat liver microsomes.
Tópico(s): Hepatitis C virus research
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Noam Bar, Tal Korem, Omer Weissbrod, David Zeevi, Daphna Rothschild, Sigal Leviatan, Noa Kosower, Maya Lotan‐Pompan, Adina Weinberger, Caroline Le Roy, Cristina Menni, Alessia Visconti, Mario Falchi, Tim D. Spector, Henrik Vestergaard, Manimozhiyan Arumugam, Torben Hansen, Kristine H. Allin, Tue H. Hansen, Mun‐Gwan Hong, Jochen M. Schwenk, Ragna S. Häussler, Matilda Dale, Toni Giorgino, Marianne Rodriquez, Mandy H. Perry, Rachel Nice, Timothy J. McDonald, Andrew T. Hattersley, Angus G. Jones, Ulrike Graefe‐Mody, Patrick Baum, Rolf Grempler, Cecilia Engel Thomas, Federico De Masi, Caroline Brorsson, Gianluca Mazzoni, Rosa Lundbye Allesøe, Simon Rasmussen, Valborg Guðmundsdóttir, Agnes Martine Nielsen, Karina Banasik, Konstantinos D. Tsirigos, Birgitte Nilsson, Helle K. Pedersen, Søren Brunak, Tugce Karaderi, Agnete Troen Lundgaard, Joachim Johansen, Ramneek Gupta, Peter Wad Sackett, J. Tillner, Thorsten Lehr, Nina Scherer, Christiane Dings, Iryna Sihinevich, Heather Loftus, Louise Cabrelli, Donna McEvoy, Andrea Mari, Roberto Bizzotto, Andrea Tura, Leen M. ‘t Hart, Koen F. Dekkers, Nienke van Leeuwen, Roderick C. Slieker, Femke Rutters, Joline W. J. Beulens, Giel Nijpels, Anitra D.M. Koopman, Sabine van Oort, Lenka Groeneveld, Leif Groop, Petra J. M. Elders, Ana Viñuela, Anna Ramisch, Emmanouil Dermitzakis, Beate Ehrhardt, Christopher Jennison, Philippe Froguel, Mickaël Canouil, Amélie Boneford, Ian McVittie, Dianne Wake, Francesca Frau, Hans‐Henrik Stærfeldt, Kofi P. Adragni, Melissa K. Thomas, Han Wu, Imre Pavo, Birgit Steckel-Hamann, Henrik S. Thomsen, Giuseppe N. Giordano, Hugo Fitipaldi, Martin Ridderstråle, Azra Kurbasic, Naeimeh Atabaki Pasdar, Hugo Pomares‐Millan, Pascal M. Mutie, Robert W. Koivula, Nicky McRobert, Mark I. McCarthy, Agata Wesolowska‐Andersen, Anubha Mahajan, Moustafa Abdalla, Juan Fernandez, Reinhard W. Holl, Alison Heggie, Harshal Deshmukh, Anita M. Hennige, Susanna Bianzano, Barbara Thorand, Sapna Sharma, Harald Grallert, Jonathan Adam, Martina Troll, Andreas Fritsche, Anita Hill, Claire E. Thorne, Michelle Hudson, Teemu Kuulasmaa, Jagadish Vangipurapu, Markku Laakso, Henna Cederberg, Tarja Kokkola, Yunlong Jiao, Stephen Gough, Neil Robertson, Hélène Verkindt, Violeta Raverdi, Robert Caïazzo, François Pattou, Margaret H. White, Louise A. Donnelly, Andrew Brown, Nicholette D. Palmer, David Davtian, Adem Y. Dawed, Ian Forgie, Ewan R. Pearson, Hartmut Ruetten, Petra Musholt, Jimmy D. Bell, E. Louise Thomas, Brandon Whitcher, Mark Haid, Claudia Nicolay, Miranda Mourby, Jane Kaye, Nisha Shah, Harriet Teare, Gary Frost, Bernd Jablonka, Mathias Uhlén, Rebeca Eriksen, Josef Korbinian Vogt, Avirup Dutta, Anna Jönsson, Line Engelbrechtsen, Annemette Forman, Nadja B. Søndertoft, Nathalie de Préville, Tania Baltauss, Mark Walker, Johann Gassenhuber, Maria Klintenberg, Margit Bergstrom, Jorge Ferrer, Jerzy Adamski, Paul W. Franks, Oluf Pedersen, Eran Segal,
The serum metabolome contains a plethora of biomarkers and causative agents of various diseases, some of which are endogenously produced and some that have been taken up from the environment1. The origins of specific compounds are known, including metabolites that are highly heritable2,3, or those that are influenced by the gut microbiome4, by lifestyle choices such as smoking5, or by diet6. However, the key determinants of most metabolites are still poorly understood. Here we measured the levels ...
Tópico(s): Bioinformatics and Genomic Networks
2020 - Nature Portfolio | Nature
Carl Lacharité, Louise S. Éthier, Christiane Piché,
The authors examine the metrological qualities of a French version of the Parenting Stress Index (Abidin, 1983; Loyd and Abidin, 1985) based on a sampling of 122 Québec mothers with a preschool child. Results show that the Parental Stress Inventory presents internal consistency indices that are equivalent to those obtained in the U.S. sampling. However, the samplings differ on seven out of 13 subscales, as well as concerning the scores obtained for the child's realm and the overall stress, Québec ...
Tópico(s): Attachment and Relationship Dynamics
2008 - Erudit Consortium | Santé mentale au Québec
Nicholas E. Ilott, James A. Heward, Benoît Roux, Eleni Tsitsiou, Peter Fenwick, Luca Lenzi, Ian Goodhead, Christiane Hertz‐Fowler, Andreas Heger, Neil Hall, Louise Donnelly, David Sims, Mark A. Lindsay,
Abstract Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of biological responses. However, their role in the human innate immune response, which provides the initial defence against infection, is largely unexplored. To address this issue, here we characterize the long non-coding RNA transcriptome in primary human monocytes using RNA sequencing. We identify 76 enhancer RNAs (eRNAs), 40 canonical lncRNAs, 65 antisense lncRNAs and 35 regions of bidirectional transcription ( ...
Tópico(s): RNA Research and Splicing
2014 - Nature Portfolio | Nature Communications
Christiane Flessas, Yves Couillard, Bernadette Pinel‐Alloul, Louise St‐Cyr, Peter G. C. Campbell,
This study assesses the potential use of two dominant freshwater gastropod species of the St. Lawrence River, Bithynia tentaculata (Prosobranchia) and Physa gyrina (Pulmonata), as biomonitors of metal pollution. Gastropods were collected in the littoral zone of Lake St. Louis and Lake St. Pierre, two shallow fluvial lakes of the St. Lawrence River, at sampling stations chosen to represent a metal concentration gradient in sediments. The soft body tissues of snails were analyzed for Cd, Cu, Ni, Pb, ...
Tópico(s): Water Quality and Pollution Assessment
2000 - Canadian Science Publishing | Canadian Journal of Fisheries and Aquatic Sciences
Megan E. Carey, Zoe A. Dyson, Danielle J. Ingle, Afreenish Amir, Mabel Kamweli Aworh, Mochammad Hatta, Ka Lip Chew, John A. Crump, Nicholas Feasey, Benjamin P. Howden, Karen H. Keddy, Mailis Maes, Christopher M. Parry, Sandra Van Puyvelde, Hattie E. Webb, Ayorinde O. Afolayan, Anna P. Alexander, Shalini Anandan, Jason R. Andrews, Philip Ashton, Buddha Basnyat, Ashish Bavdekar, Isaac I. Bogoch, John D. Clemens, Késia Esther da Silva, Anuradha De, Joep de Ligt, Paula Díaz, Christiane Dolecek, Shanta Dutta, Marthie M. Ehlers, Louise Francois Watkins, Denise O Garrett, Gauri Godbole, Melita A. Gordon, Andrew R. Greenhill, Chelsey Griffin, Madhu Gupta, René S. Hendriksen, Robert S. Heyderman, Yogesh Hooda, Juan Carlos Hormazábal, Odion O. Ikhimiukor, Junaid Iqbal, Jobin John Jacob, Claire Jenkins, Dasaratha Ramaiah Jinka, Jacob John, Gagandeep Kang, Abdoulie Kanteh, Arti Kapil, Abhilasha Karkey, Samuel Kariuki, Robert A. Kingsley, Roshine Mary Koshy, A.C. Lauer, Myron M. Levine, Ravikumar Kadahalli Lingegowda, Stephen P. Luby, Grant Mackenzie, Tapfumanei Mashe, Chisomo Msefula, Ankur Mutreja, Geetha Nagaraj, Savitha Nagaraj, Satheesh Nair, Take Naseri, Susana Nimarota-Brown, Elisabeth Njamkepo, Iruka N. Okeke, Sulochana Putli Bai Perumal, Andrew J. Pollard, Agila Kumari Pragasam, Firdausi Qadri, Farah Naz Qamar, Sadia Rahman, Savitra Rambocus, David A. Rasko, Pallab Ray, Roy M. Robins‐Browne, Temsunaro Rongsen‐Chandola, Jean Pierre Rutanga, Samir K. Saha, Senjuti Saha, Karnika Saigal, Mohammad Saiful Islam Sajib, Jessica C. Seidman, Jivan Shakya, Varun Shamanna, Jayanthi Shastri, Rajeev Shrestha, Sonia Sia, Michael J. Sikorski, Ashita Singh, Anthony M. Smith, Kaitlin A. Tagg, Dipesh Tamrakar, Arif Mohammad Tanmoy, Maria Thomas, M. Thomas, Robert Thomsen, Nicholas R. Thomson, Siaosi Tupua, Krista Vaidya, Mary Valcanis, Balaji Veeraraghavan, François‐Xavier Weill, Jackie Wright, Gordon Dougan, Silvia Argimón, Jacqueline A. Keane, David M. Aanensen, Stephen Baker, Kathryn E. Holt,
The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse
Tópico(s): Viral gastroenteritis research and epidemiology
2023 - eLife Sciences Publications Ltd | eLife
Nicholas E. Ilott, James A. Heward, Benoît Roux, Eleni Tsitsiou, Peter Fenwick, Luca Lenzi, Ian Goodhead, Christiane Hertz‐Fowler, Andreas Heger, Neil Hall, Louise Donnelly, David Sims, Mark A. Lindsay,
Nature Communications 5: Article number: 3979 (2014); Published 9 June 2014; Updated 9 April 2015. The original version of this Article contained a typographical error in the spelling of the author Nicholas E. Ilott, which was incorrectly given as Nicholas E. IIott. This has now been corrected in both the PDF and HTML versions of the Article.
2015 - Nature Portfolio | Nature Communications