Stephanie Jungmichel, Julie A. Clapperton, Janette Lloyd, Flurina J. Hari, Christoph Spycher, Lucijana Pavic, Jiejin Li, L.F. Haire, Mario Bonalli, Dorthe Helena Larsen, Claudia Lukas, Jiří Lukáš, Derek Macmillan, Michael L. Nielsen, Manuel Stucki, Stephen J. Smerdon,
Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with the tail of γH2AX following DNA damage, but the role of the N-terminal forkhead-associated (FHA) domain remains unclear. We show that a major binding target of the Mdc1 FHA domain is a previously unidentified DNA damage and ATM-dependent phosphorylation site near the N-terminus ...
Tópico(s): Cancer-related Molecular Pathways
2012 - Oxford University Press | Nucleic Acids Research
Flurina J. Hari, Christoph Spycher, Stephanie Jungmichel, Lucijana Pavic, Manuel Stucki,
The MRE11–RAD50–NBS1 (MRN) complex accumulates at sites of DNA double‐strand breaks in large chromatin domains flanking the lesion site. The mechanism of MRN accumulation involves direct binding of the Nijmegen breakage syndrome 1 (NBS1) subunit to phosphorylated mediator of the DNA damage checkpoint 1 (MDC1), a large nuclear adaptor protein that interacts directly with phosphorylated H2AX. NBS1 contains an FHA domain and two BRCT domains at its amino terminus. Here, we show that both of these domains ...
Tópico(s): Genomics and Chromatin Dynamics
2010 - Springer Nature | EMBO Reports
Christoph Spycher, Edward S. Miller, Kelly Townsend, Lucijana Pavic, Nicholas A. Morrice, Pavel Janščák, Grant S. Stewart, Manuel Stucki,
The MRE11–RAD50–Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in microscopically discernible nuclear foci. Focus formation by the MRN complex is dependent on MDC1, a large nuclear protein that directly interacts with phosphorylated H2AX. In this study, we identified a region in MDC1 that is essential for the focal accumulation of the MRN complex at sites of DNA damage. This region contains multiple conserved acidic sequence motifs that are ...
Tópico(s): Plant Genetic and Mutation Studies
2008 - Rockefeller University Press | The Journal of Cell Biology
María G. Olguín-Martínez, Loïc Peiffer, Patrick Dobson, Nicolas Spycher, Claudio Inguaggiato, Christoph Wanner, Angello Hoyos, Jobst Wurl, Kyle Makovsky, Diego Ruiz-Aguilar,
Multicomponent solute geothermometry is a useful tool for estimating the temperature of a deep geothermal reservoir prior to exploration drilling. The method uses full water analyses to determine the temperature at which the saturation indices of an assemblage of reservoir minerals reflect equilibrium with the water. One of the challenges with this method is selecting the mineral assemblage to be used for the computations. A new pre- and post-processing tool, PyGeoT, has been developed to answer ...
Tópico(s): CO2 Sequestration and Geologic Interactions
2022 - Elsevier BV | Geothermics
Jan Gralla, Franziska Spycher, Christine Pignolet, Christoph Ozdoba, Peter Vock, Hanno Hoppe,
OBJECTIVE. MDCT is especially suited for emergency purposes because it allows rapid high-resolution scans of large areas, fast high-quality reformatting in every orientation, and 3D illustration of the data set. In a prospective study, we evaluated the reliability and workflow of a dedicated emergency department 16-MDCT scanner in the management of patients presenting to the emergency department.
Tópico(s): Medical Imaging Techniques and Applications
2005 - American Roentgen Ray Society | American Journal of Roentgenology
Loïc Peiffer, Christoph Wanner, Nicolas Spycher, Eric Sonnenthal, B. Mack Kennedy, Joe Iovenitti,
A new geothermometry approach is explored, incorporating multicomponent geothermometry coupled with numerical optimization to provide more confident estimates of geothermal reservoir temperatures when results of classical geothermometers are inconsistent. This approach is applied to geothermal well and spring waters from the Dixie Valley geothermal area (Nevada), to evaluate the influence of salt brines mixing and dilution of geothermal fluids on calculated temperatures. The main advantage of the ...
Tópico(s): Groundwater flow and contamination studies
2014 - Elsevier BV | Geothermics
Caroline Tinguely, Therese Schild-Spycher, Zahra Bahador, Peter Gowland, Martin Stolz, Christoph Niederhauser,
The performance of the rapid confirmatory HIV 1/2 assay Geenius was compared with the conventional HIV 1/2 line immunoblot (INNO-LIA HIV I/II Score). One hundred HIV 1/2 confirmed positive samples from donors and patients and 136 negative screening samples from blood donors were evaluated with both assays. A 20 member performance panel consisting of different HIV 1 and 2 subtypes was also analysed. Ninety-nine of the confirmed HIV positive samples were positive with both assays. One sample was positive ...
Tópico(s): HIV/AIDS Research and Interventions
2014 - Elsevier BV | Journal of Virological Methods
Christoph Wanner, Loïc Peiffer, Eric Sonnenthal, Nicolas Spycher, Joe Iovenitti, B. Mack Kennedy,
A 2D reactive transport model of the Dixie Valley geothermal area in Nevada, USA was developed to assess fluid flow pathways and fluid rock interaction processes. The model includes two major normal faults and the incorporation of a dual continuum domain to simulate the presence of a small-scale thermal spring being fed by a highly permeable but narrow fracture zone. Simulations were performed incorporating fluid flow, heat conduction and advection, and kinetic mineral-water reactions. Various solute ...
Tópico(s): Groundwater and Isotope Geochemistry
2014 - Elsevier BV | Geothermics
Maurane Riesen, Garyfallos Konstantinoudis, Phung Lang, Nicola Low, Christoph Hatz, Mirjam Maeusezahl, Anne Spaar, Marc Bühlmann, Ben D. Spycher, Christian L. Althaus,
Understanding the factors that influence human papillomavirus (HPV) vaccination uptake is critically important to the design of effective vaccination programmes. In Switzerland, HPV vaccination uptake (≥1 dose) by age 16 years among women ranges from 31% to 80% across 26 cantons (states). Our objective was to identify factors that are associated with the spatial variation in HPV vaccination uptake.We used cross-sectional data from the Swiss National Vaccination Coverage Survey 2009-2016 on HPV vaccination ...
Tópico(s): Global Cancer Incidence and Screening
2018 - BMJ | BMJ Open
Éric Giannoni, Philipp Agyeman, Martin Stocker, Klara M. Posfay‐Barbe, Ulrich Heininger, Ben D. Spycher, Sara Bernhard‐Stirnemann, Anita Niederer-Loher, Christian R. Kahlert, Alex Donas, Antonio Maria Leone, Paul Hasters, Christa Relly, Thomas Riedel, Claudia E. Kuehni, Christoph Aebi, Christoph Berger, Luregn J. Schlapbach,
Objective To assess the epidemiology of blood culture-proven early- (EOS) and late-onset neonatal sepsis (LOS). Study design All newborn infants admitted to tertiary care neonatal intensive care units in Switzerland and presenting with blood culture-proven sepsis between September 2011 and December 2015 were included in the study. We defined EOS as infection occurring 48 hours after admission. Incidence was estimated based on the number of livebirths in Switzerland and adjusted for the proportion ...
Tópico(s): Streptococcal Infections and Treatments
2018 - Elsevier BV | The Journal of Pediatrics
Dorita Avila, Olivia Keiser, Matthias Egger, Roger D. Kouyos, Jürg Böni, Sabine Yerly, Thomas Klimkait, Pietro Vernazza, Vincent Aubert, Andri Rauch, Sebastian Bonhoeffer, Huldrych F. Günthard, Tanja Stadler, Ben D. Spycher, Vincent Aubert, Julia M. I. Barth, Manuel Battegay, Enos Bernasconi, Jürg Böni, Heiner C. Bucher, Claudine Burton‐Jeangros, Alexandra Calmy, Matthias Cavassini, Matthias Egger, Luigia Elzi, Jan Fehr, Jacques Fellay, Hansjakob Furrer, Christoph A. Fux, Meri Gorgievski, Huldrych F. Günthard, David Haerry, Barbara Hasse, Hans H. Hirsch, Irène Hösli, Christian R. Kahlert, Laurent Kaiser, Olivia Keiser, Thomas Klimkait, Roger D. Kouyos, Helen Kovari, Bruno Ledergerber, G Martinetti, Begoña Martínez de Tejada, Karin J. Metzner, Nicolas Müller, David Nadal, G Pantaleo, Andri Rauch, Stephan Regenass, Martin Rickenbach, Christoph Rudin, F. Schöni-Affolter, Patrick Schmid, D. Schultze, Jörg Schüpbach, Roberto F. Speck, Cornelia Staehelin, Philip Tarr, Amalio Telenti, Alexandra Trkola, Pietro Vernazza, Rainer Weber, Sabine Yerly,
Switzerland has a complex human immunodeficiency virus (HIV) epidemic involving several populations. We examined transmission of HIV type 1 (HIV-1) in a national cohort study. Latent class analysis was used to identify socioeconomic and behavioral groups among 6,027 patients enrolled in the Swiss HIV Cohort Study between 2000 and 2011. Phylogenetic analysis of sequence data, available for 4,013 patients, was used to identify transmission clusters. Concordance between sociobehavioral groups and transmission ...
Tópico(s): Animal Disease Management and Epidemiology
2014 - Oxford University Press | American Journal of Epidemiology
Loïc Peiffer, Christoph Wanner, Nicolas Spycher, Eric Sonnenthal, B. Mack Kennedy,
Reactive transport simulations were used to examine the chemical evolution of deep geothermal fluids as they ascend to the surface, and to assess constraints on the application of solute geothermometers. Al and Mg concentrations of deep fluids are sensitive to precipitation-dissolution processes, affecting reservoir temperatures estimated with multicomponent geothermometry. The concentrations of major elements such as Na, K, and SiO2 are less sensitive to reequilibration, and thus geothermometers ...
Tópico(s): Geothermal Energy Systems and Applications
2013 - Elsevier BV | Procedia Earth and Planetary Science
Christoph Wanner, Loïc Peiffer, Eric Sonnenthal, Nicolas Spycher, Joe Iovenitti, B. Mack Kennedy,
A 2D reactive transport model of the Dixie Valley geothermal field in Nevada, USA was developed to assess the conditions under which chemical geothermometers operate as powerful exploration tools. Model concentrations read out at the surface were processed by multicomponent geothermometry to compare inferred reservoir temperatures with true reservoir temperatures of the model. Varying reactive fracture surface areas revealed that re-equilibration does not occur if the effective fracture surface ...
Tópico(s): Groundwater flow and contamination studies
2013 - Elsevier BV | Procedia Earth and Planetary Science
Süleyman Tolga Yavuz, Ozan Koc, Ali Güngör, Faysal Gök, Jessica E. Hawley, Christopher J. O’Brien, Matthew F. Thomas, Malcolm Brodlie, Louise J. Michaelis, Inês Mota, Angéla Gáspár, Susana Piedade, Graça Sampaio, José Geraldo Dias, Miguel Paiva, Mário Morais‐Almeida, Cristina Madureira, Tânia Lopes, Susana Lopes, Filipa Almeida, Alexandra Sequeira, Fernanda Carvalho, José Inácio de Oliveira, Fabienne Gay-Crosier, Ioana-Valentina Nenciu, Andreia Nita, Alexandru Ulmeanu, Dumitru Orăşeanu, Carmen Zăpucioiu, Adrianna Machinena, Olga Domínguez Sánchez, Montserrat Álvaro‐Lozano, Rosa Feijoo, Jaime Lozano Blasco, Mònica Piquer Gibert, M.T. Giner Muñoz, M. Dias da Costa, Ana Martín, Ebru Arık Yılmaz, Özlem Cavkaytar, Betül Büyüktiryaki, Özge Soyer, Cansın Saçkesen, Merryn J. Netting, Adaweyah El-Merhibi, Michael Gold, Patrick Quinn, Irmeli Penttila, Maria Makrides, Stavroula Giavi, Antonella Muraro, Roger Lauener, Annick Mercenier, Eugen Bersuch, Isabella Monia Montagner, Maria Passioti, Nicolò Celegato, Selina Summermatter, Sophie Nutten, Tristan Bourdeau, Yvonne M. Vissers, Nikolaos G. Papadopoulos, Hanneke van der Kleij, Hans Warmenhoven, Ronald van Ree, Raymond Pieters, Dirk Jan E. Opstelten, Hans van Schijndel, Joost J. Smit, Róisín Fitzsimons, Victoria Timms, George Du Toit, Güven Kaya, Mustafa Güleç, Mehmet Saldır, Osman Şener, Nagwa Hassan, Hala Shaaban, Hazem M. El-Hariri, Ahmed Kamel Inas E. Mahfouz, Papp Gabor, G. Bíró, K Csaba, Bo Chawes, Klaus Bønnelykke, Jakob Stokholm, Lene Heickendorff, Susanne Brix, Morten Arendt Rasmussen, Hans Bisgaard, Henrik Wegener Hallas, Lambang Arianto, Maike Pincus, Thomas Keil, Andreas Reich, Ulrich Wahn, Susanne Lau, Linus Grabenhenrich, Sara Fagerstedt, Helena Marell Hesla, Emelie Johansson, Helen Rosenlund, Axel Mie, Annika Scheynius, Johan Alm, Jorge Esparza-Gordillo, Anja Matanovic, Ingo Marenholz, Anja Bauerfeind, Klaus Rohde, Katja Nemat, Min-Ae Lee-Kirsch, Magnus Nordenskjöld, M.C.G. Winge, Renate Krüger, Kirsten Beyer, Birgit Kalb, B. Niggemann, Norbert Hübner, Heather J. Cordell, Maria Bradley, Young‐Ae Lee, Hannah Gough, Dirk Schramm, John Beschorner, Antje Schuster, Carl‐Peter Bauer, Johannes Förster, Fred Zepp, Renate L. Bergmann, Karl‐Christian Bergmann, Filipe Benito Garcia, Natacha Santos, Helena Pité, Athina Papadopoulou, Despina Mermiri, Xatziagorou Elpida, Ioannis Tsanakas, Stavroula Lampidi, Kostas Ν. Priftis, Elaine Fuertes, Iana Markevych, Gayan Bowatte, Olena Gruzieva, Ulrike Gehring, Allan B. Becker, Dietrich Berdel, Michael Bräuer, Chris Carlsten, Barbara Hoffmann, Anita L. Kozyrskyj, Caroline Lodge, Göran Pershagen, Alet H. Wijga, Heinrich Joachim, Zorica Živković, Ivana Djuric-Filipovic, Jasmina Jocić-Stevanovic, Snežana Zivanovic, Styliani Τaka, Dimitra Kokkinou, Aliki Papakonstantinou, Panagiota Stefanopoulou, Anastasia Georgountzou, Paraskevi Maggina, Sofia Stamataki, Vassiliki Papaevanggelou, Evangelos Andreakos, Mònica Piquer Gibert, Adriana Machinena Spera, Matea Deliu, Danielle Belgrave, Angela Simpson, Adnan Ćustović, João Gaspar Marques, Pedro Martins, Joana Belo, Sara Serranho, I Peralta, Nuno Neuparth, Paula Pinto, Marta Vázquez‐Ortiz, Mariona Pascal, Ana María Plaza, Manel Juan, Lorella Paparo, Rita Nocerino, Rosita Aitoro, I. Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni Canani, Santanu Maity, Giuseppina Rotiroti, Minal Gandhi, Karin Jönsson, Annika Ljung, Bill Hesselmar, Ingegerd Adlerbert, Hilde K. Brekke, Susanne Johansen, Agnes E. Wold, Ann‐Sofie Sandberg, Björn Nordlund, Cecilia Lundholm, Villhelmina Ullemar, Marianne van Hage, Anne K. Örtqvist, Catarina Almqvist, Anna Selby, Kate Grimshaw, Michael Clausen, Rūta Dubakienė, Alessandro Fiocchi, Marek L. Kowalski, Nikolaos G. Papadopoulos, Marta Reche, Sigurveig Sigurdardottir, Aline Sprikkleman, Paraskevi Xepapadaki, E. N. Clare Mills, Graham Roberts, Herberto José Chong‐Neto, Gustavo Falbo Wandalsen, Ana Carolina Dela Bianca, Carolina Sánchez Aranda, Nelson Augusto Rosário Filho, Dirceu Solé, Javier Mallol, Luis García‐Marcos, Ivana Banić, Matija Rijavec, Davor Plavec, Peter Korošec, Mirjana Turkalj, Alen Božičević, Maria De Mieri, Matthias Hamburger, Simone Holley, Ruth Morris, Frances Mitchell, Rebecca Knibb, Sue Latter, Christina Liossi, Mostafa M. Hassan, Malin Barman, Anna Sandin, Daniela Posa, Serena K. Perna, Ute Hoffmann, Kuan‐Wei Chen, Yvonne Resch, Susanne Vrtala, Rudolf Valenta, Paolo Maria Matricardi, Olympia Tsilochristou, Alexander Rohrbach, Antonio Cappella, Stephanie Hofmaier, Laura Hatzler, Raffaele D’Amelio, Sophia Björkander, Maria A. Johansson, Gintare Lasaviciute, Eva Sverremark‐Ekström, Franz Rüschendorf, David P. Strachan, Ben D. Spycher, Hansjörg Baurecht, Patricia Margaritte‐Jeannin, Annika Sääf, Marjan Kerkhof, Markus Ege, Svetlana Baltic, Melanie C. Matheson, Jin Li, Sven Michel, Wei Ang, Wendy L. McArdle, Andreas Arnold, Georg Homuth, Florence Démenais, Emmanuelle Bouzigon, Cilla Söderhäll, Johan C. de Jongste, Dirkje S. Postma, Charlotte Braun‐Fahrländer, Elisabeth Horak, Л. М. Огородова, В. П. Пузырев, E. Yu. Bragina, Thomas J. Hudson, Charles Morin, David L. Duffy, Guy B. Marks,
... Rüschendorf, Anja Bauerfeind, David P. Strachan, Ben D. Spycher, Hansjörg Baurecht, Patricia Margaritte-Jeannin, Annika Sääf, Marjan ... Hamid Bigdelian, Nahid Raeesi, Mino Afshar, Hamid Rahimi, Christoph Klein PP54 A case study: the effect of ...
Springer Science+Business Media
S. Sevinç Şengör, K. Ulrich Mayer, Janek Greskowiak, Christoph Wanner, Danyang Su, Henning Prommer,
... on the multicomponent biogeochemical reaction network presented by Spycher et al. (Geochim Cosmochim Acta 75:4426–4440, ...
Tópico(s): CO2 Sequestration and Geologic Interactions
2015 - Springer Science+Business Media | Computational Geosciences
Manon Jaboyedoff, Milenko Rakic, Sara Bachmann, Christoph Berger, Manuel Diezi, Oliver Fuchs, Urs Frey, Alain Gervaix, Amalia Stefani Glücksberg, Michael Grotzer, Ulrich Heininger, Christian R. Kahlert, Daniela Kaiser, Matthias Kopp, Roger Lauener, Thomas J. Neuhaus, P Paioni, Klara M. Posfay‐Barbe, Gian Paolo Ramelli, Umberto Siméoni, Giacomo D. Simonetti, Christiane Sokollik, Ben D. Spycher, Claudia E. Kuehni,
BACKGROUND: Improvement of paediatric healthcare is hampered by inefficient processes for generating new evidence. Clinical research often requires extra encounters with patients, is costly, takes place in an artificial situation with a biased selection of patients, and entails long delays until new evidence is implemented into health care. Electronic health records (EHR) contain detailed information on real patients and cover the entirety of patients. However, the use of EHR for research is limited ...
Tópico(s): Neonatal Respiratory Health Research
2021 - EMH Swiss Medical Publishers Ltd. | Schweizerische medizinische Wochenschrift
Lorenz M. Leuenberger, Fabiën N. Belle, Rebeca Mozún, Ben D. Spycher, Maria Christina Mallet, Oskar G. Jenni, Christoph Saner, Philipp Latzin, Alexander Mœller, Claudia E. Kuehni,
Tópico(s): Cognitive Abilities and Testing
2025 - EMH Swiss Medical Publishers Ltd. | Schweizerische medizinische Wochenschrift
Milenko Rakic, Manon Jaboyedoff, Sara Bachmann, Christoph Berger, Manuel Diezi, Philipp do Canto, Christopher B. Forrest, Urs Frey, Oliver Fuchs, Alain Gervaix, Amalia Stefani Gluecksberg, Michael Grotzer, Ulrich Heininger, Christian R. Kahlert, Daniela Kaiser, Matthias Kopp, Roger Lauener, Thomas J. Neuhaus, P Paioni, Klara M. Posfay‐Barbe, Gian Paolo Ramelli, Umberto Siméoni, Giacomo D. Simonetti, Christiane Sokollik, Ben D. Spycher, Claudia E. Kuehni,
Abstract Background and purpose Continuous improvement of health and healthcare system is hampered by inefficient processes of generating new evidence, particularly in the case of rare diseases and paediatrics. Currently, most evidence is generated through specific research projects, which typically require extra encounters with patients, are costly and entail long delays between the recognition of specific needs in healthcare and the generation of necessary evidence to address those needs. The ...
Tópico(s): Health and Medical Studies
2021 - BioMed Central | BMC Proceedings