Robyn P. Thom, Christopher J. Keary, Gabriel Kramer, Lisa A. Nowinski, Christopher J. McDougle,
Although autism spectrum disorder (ASD) is the prototypical psychiatric disorder of social impairment, several if not most psychiatric disorders are characterized by prominent impairments in social functioning. A challenge in clinically assessing and describing social impairment is that it has been variably defined and can be difficult to measure. In this article we consider the psychiatric differential diagnosis of social impairment within the DSM-5 framework. We describe the features of social ...
Tópico(s): Obsessive-Compulsive Spectrum Disorders
2020 - Lippincott Williams & Wilkins | Harvard Review of Psychiatry
Michael L. Alosco, Micaela White, Carter Bell, Farwa Faheem, Yorghos Tripodis, Eukyung Yhang, Zachary Baucom, Brett Martin, Joseph Palmisano, Kristen Dams-O’Connor, John F. Crary, Lee E. Goldstein, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher J. Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Victor E. Alvarez, Bertrand R. Huber, Thor D. Stein, Ann C. McKee, Jesse Mez,
Abstract Background Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The clinical features associated with CTE pathology are unclear. In brain donors with autopsy-confirmed CTE, we investigated the association of CTE p-tau pathology density and location with cognitive, functional, and neuropsychiatric symptoms. Methods In 364 brain donors with autopsy confirmed CTE, semi-quantitative p-tau severity (range: 0–3) was ...
Tópico(s): Dementia and Cognitive Impairment Research
2024 - BioMed Central | Molecular Neurodegeneration
William Stewart, Michael E. Buckland, Bobak Abdolmohammadi, Andrew J. Affleck, Victor E. Alvarez, Shannon E. Gilchrist, Bertrand R. Huber, Edward B. Lee, Donald M. Lyall, Christopher J. Nowinski, Emma Russell, Thor D. Stein, Catherine M. Suter, Ann C. McKee,
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2023 - Springer Science+Business Media | Acta Neuropathologica
Daniel H. Daneshvar, Evan Nair, Zachary Baucom, Abigail Rasch, Bobak Abdolmohammadi, Madeline Uretsky, Nicole Saltiel, Arsal Shah, Johnny Jarnagin, Christine M. Baugh, Brett Martin, Joseph Palmisano, Jonathan D. Cherry, Victor E. Alvarez, Bertrand R. Huber, Jennifer Weuve, Christopher J. Nowinski, Robert C. Cantu, Ross Zafonte, Brigid Dwyer, John F. Crary, Lee E. Goldstein, Neil W. Kowall, Douglas I. Katz, Robert A. Stern, Yorghos Tripodis, Thor D. Stein, Michael D. McClean, Michael L. Alosco, Ann C. McKee, Jesse Mez,
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI), but the components of RHI exposure underlying this relationship are unclear. We create a position exposure matrix (PEM), composed of American football helmet sensor data, summarized from literature review by player position and level of play. Using this PEM, we estimate measures of lifetime RHI exposure for a separate cohort of 631 football playing brain donors. Separate models examine ...
Tópico(s): Automotive and Human Injury Biomechanics
2023 - Nature Portfolio | Nature Communications
Nora D.B. Friedman, Laura C. Politte, Lisa A. Nowinski, Christopher J. McDougle,
In comparison to patients with autism, research has suggested that those with childhood disintegrative disorder generally have more severe intellectual disability (ID) and poorer outcomes. Although the genetic contributions to autism remain extremely heterogeneous, recent research continues to suggest strong, though varied, genetic underpinnings. Individuals with autism are often quite comfortable engaging in repetitive play, motor movements, or scripted speech and can become distressed when they ...
Tópico(s): Family and Disability Support Research
2015 - Taylor & Francis | Psychiatry
W R Green, Robert C. Nowinski, Christopher S. Henney,
Tópico(s): CAR-T cell therapy research
1980 - American Association of Immunologists | The Journal of Immunology
Michael L. Alosco, Monica T. Ly, Sydney Mosaheb, Nicole Saltiel, Madeline Uretsky, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Lisa Delano‐Wood, Mark W. Bondi, Gaoyuan Meng, Weiming Xia, Sarah Daley, Lee E. Goldstein, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher J. Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Victor E. Alvarez, Jesse Mez, Bertrand R. Huber, Ann C. McKee, Thor D. Stein,
Abstract American football players and other individuals exposed to repetitive head impacts can exhibit a constellation of later-life cognitive and neuropsychiatric symptoms. While tau-based diseases such as chronic traumatic encephalopathy can underpin certain symptoms, contributions from non-tau pathologies from repetitive head impacts are increasingly recognized. We examined cross-sectional associations between myelin integrity using immunoassays for myelin-associated glycoprotein and proteolipid ...
Tópico(s): Cardiac Arrest and Resuscitation
2023 - Oxford University Press | Brain Communications
Nicole Saltiel, Yorghos Tripodis, Talia J. Menzin, Aliyah Olaniyan, Zach H. Baucom, Eukyung Yhang, Joseph Palmisano, Brett Martin, Madeline Uretsky, Evan Nair, Bobak Abdolmohammadi, Arsal Shah, Raymond Nicks, Christopher J. Nowinski, Robert C. Cantu, Daniel H. Daneshvar, Brigid Dwyer, Douglas I. Katz, Robert A. Stern, Victor E. Alvarez, Bertrand R. Huber, Patricia A. Boyle, Julie A. Schneider, Jesse Mez, Ann C. McKee, Michael L. Alosco, Thor D. Stein,
Objective Exposure to repetitive head impacts (RHI) is associated with later‐life cognitive symptoms and neuropathologies, including chronic traumatic encephalopathy (CTE). Cognitive decline in community cohorts is often due to multiple pathologies; however, the frequency and contributions of these pathologies to cognitive impairment in people exposed to RHI are unknown. Here, we examined the relative contributions of 13 neuropathologies to cognitive symptoms and dementia in RHI‐exposed brain donors. ...
Tópico(s): Cerebrospinal fluid and hydrocephalus
2023 - Wiley | Annals of Neurology
... D.B. Friedman, Laura C. Politte, Lisa A. Nowinski, Christopher J. McDougle, Psychiatry, [1]Re‐examining the core ...
Tópico(s): RNA regulation and disease
2007 - Wiley | Pediatrics International
Christopher J. Nowinski, Hye Chang Rhim, Ann C. McKee, Ross Zafonte, David W. Dodick, Robert C. Cantu, Daniel H. Daneshvar,
Tópico(s): Traumatic Ocular and Foreign Body Injuries
2024 - BMJ | British Journal of Sports Medicine
Ann C. McKee, Jesse Mez, Bobak Abdolmohammadi, Morgane Butler, Bertrand R. Huber, Madeline Uretsky, Katharine J. Babcock, Jonathan D. Cherry, Victor E. Alvarez, Brett Martin, Yorghos Tripodis, Joseph Palmisano, Kerry A. Cormier, Caroline A. Kubilus, Raymond Nicks, Daniel Kirsch, Ian Mahar, Lisa McHale, Christopher J. Nowinski, Robert C. Cantu, Robert A. Stern, Daniel H. Daneshvar, Lee E. Goldstein, Douglas I. Katz, Neil W. Kowall, Brigid Dwyer, Thor D. Stein, Michael L. Alosco,
Young contact sport athletes may be at risk for long-term neuropathologic disorders, including chronic traumatic encephalopathy (CTE).
Tópico(s): Cardiac Arrest and Resuscitation
2023 - American Medical Association | JAMA Neurology
Produção Nacional
Revisado por pares
Christopher J. Nowinski, Samantha Bureau, Michael E. Buckland, Maurice A. Curtis, Daniel H. Daneshvar, Richard L. M. Faull, Lea T. Grinberg, Elisa L. Hill‐Yardin, Helen C. Murray, Alan J. Pearce, Catherine M. Suter, Adam White, Adam M. Finkel, Robert C. Cantu,
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with a history of repetitive head impacts (RHI). CTE was described in boxers as early as the 1920s and by the 1950s it was widely accepted that hits to the head caused some boxers to become “punch drunk.” However, the recent discovery of CTE in American and Australian-rules football, soccer, rugby, ice hockey, and other sports has resulted in renewed debate on whether the relationship between RHI and CTE is causal. Identifying ...
Tópico(s): Child Abuse and Related Trauma
2022 - Frontiers Media | Frontiers in Neurology
Kathryn Atherton, Xudong Han, Jaeyoon Chung, Jonathan D. Cherry, Zachary Baucom, Nicole Saltiel, Evan Nair, Bobak Abdolmohammadi, Madeline Uretsky, Mohammed Muzamil Khan, Conor Shea, Shruti Durape, Brett Martin, Joseph Palmisano, Kurt Farrell, Christopher J. Nowinski, Victor E. Alvarez, Brigid Dwyer, Daniel H. Daneshvar, Douglas I. Katz, Lee E. Goldstein, Robert C. Cantu, Neil W. Kowall, Michael L. Alosco, Bertrand R. Huber, Yorghos Tripodis, John F. Crary, Lindsay A. Farrer, Robert A. Stern, Thor D. Stein, Ann C. McKee, Jesse Mez,
Repetitive head impact (RHI) exposure is the chief risk factor for chronic traumatic encephalopathy (CTE). However, the occurrence and severity of CTE varies widely among those with similar RHI exposure. Limited evidence suggests that the APOEε4 allele may confer risk for CTE, but previous studies were small with limited scope.To test the association between APOE genotype and CTE neuropathology and related endophenotypes.This cross-sectional genetic association study analyzed brain donors from February ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2022 - American Medical Association | JAMA Neurology
Madeline Uretsky, Sylvain Bouix, Ronald Killiany, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Asim Mian, Karen Buch, Chad W. Farris, Daniel H. Daneshvar, Brigid Dwyer, Lee E. Goldstein, Douglas I. Katz, Christopher J. Nowinski, Robert C. Cantu, Neil W. Kowall, Bertrand R. Huber, Robert A. Stern, Victor E. Alvarez, Thor D. Stein, Ann C. McKee, Jesse Mez, Michael L. Alosco,
Late neuropathologies of repetitive head impacts from contact sports can include chronic traumatic encephalopathy (CTE) and white matter degeneration. White matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) MRI scans are often viewed as microvascular disease from vascular risk, but might have unique underlying pathologies and risk factors in the setting of repetitive head impacts. We investigated the neuropathologic correlates of antemortem WMH in brain donors exposed to ...
Tópico(s): Cerebrospinal fluid and hydrocephalus
2021 - Lippincott Williams & Wilkins | Neurology
Michael L. Alosco, Asim Mian, Karen Buch, Chad W. Farris, Madeline Uretsky, Yorghos Tripodis, Zachary Baucom, Brett Martin, Joseph Palmisano, Christian Puzo, Ting Fang Alvin Ang, Prajakta Joshi, Lee E. Goldstein, Rhoda Au, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher J. Nowinski, Robert C. Cantu, Neil W. Kowall, Bertrand R. Huber, Victor E. Alvarez, Robert A. Stern, Thor D. Stein, Ronald Killiany, Ann C. McKee, Jesse Mez,
Abstract Background Chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, cannot currently be diagnosed during life. Atrophy patterns on magnetic resonance imaging could be an effective in vivo biomarker of CTE, but have not been characterized. Mechanisms of neurodegeneration in CTE are unknown. Here, we characterized macrostructural magnetic resonance imaging features of brain donors with autopsy-confirmed CTE. The association between hyperphosphorylated tau (p-tau) and atrophy on ...
Tópico(s): Cerebrospinal fluid and hydrocephalus
2021 - BioMed Central | Alzheimer s Research & Therapy
Jesse Mez, Michael L. Alosco, Daniel H. Daneshvar, Nicole Saltiel, Zachary Baucom, Bobak Abdolmohammadi, Madeline Uretsky, Raymond Nicks, Brett Martin, Joseph Palmisano, Christopher J. Nowinski, Philip H. Montenigro, Todd M. Solomon, Ian Mahar, Jonathan D. Cherry, Victor E. Alvarez, Brigid Dwyer, Lee E. Goldstein, Douglas I. Katz, Robert C. Cantu, Neil W. Kowall, Yorghos Tripodis, Bertrand R. Huber, Thor D. Stein, Robert A. Stern, Ann C. McKee,
Validity of the 2014 traumatic encephalopathy syndrome (TES) criteria, proposed to diagnose chronic traumatic encephalopathy (CTE) in life, has not been assessed.A total of 336 consecutive brain donors exposed to repetitive head impacts from contact sports, military service, and/or physical violence were included. Blinded to clinical information, neuropathologists applied National Institute on Neurological Disorders and Stroke/National Institute of Biomedical Imaging and Bioengineering CTE criteria. ...
Tópico(s): Trauma and Emergency Care Studies
2021 - Wiley | Alzheimer s & Dementia
Daniel H. Daneshvar, Jesse Mez, Michael L. Alosco, Zachary Baucom, Ian Mahar, Christine M. Baugh, Jhaqueline P. Valle, Jennifer Weuve, Sabrina Paganoni, Robert C. Cantu, Ross Zafonte, Robert A. Stern, Thor D. Stein, Yorghos Tripodis, Christopher J. Nowinski, Ann C. McKee,
Importance Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease; understanding ALS risk factors is a critical public health issue. Objectives To evaluate the incidence of and mortality from ALS in National Football League (NFL) athletes and to describe characteristics associated with ALS within this cohort. Design, Setting, and Participants This population-based cohort study included all 19 423 NFL athletes who debuted between 1960 and 2019 and played 1 or more professional game. It was ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2021 - American Medical Association | JAMA Network Open
Jason W. Adams, Michael L. Alosco, Jesse Mez, Victor E. Alvarez, Bertrand R. Huber, Yorghos Tripodis, Charles H. Adler, Carol Kubilius, Kerry A. Cormier, Rebecca Mathais, Raymond Nicks, Hunter Kelley, Nicole Saltiel, Madeline Uretsky, Evan Nair, Nurgül Aytan, Jonathan D. Cherry, Christopher J. Nowinski, Neil W. Kowall, Lee E. Goldstein, Brigid Dwyer, Douglas I. Katz, Robert C. Cantu, Robert A. Stern, Ann C. McKee, Thor D. Stein,
Tópico(s): Spinal Cord Injury Research
2020 - Springer Science+Business Media | Acta Neuropathologica
Jesse Mez, Daniel H. Daneshvar, Bobak Abdolmohammadi, Alicia S. Chua, Michael L. Alosco, Patrick T. Kiernan, Laney Evers, Laura G. Marshall, Brett Martin, Joseph Palmisano, Christopher J. Nowinski, Ian Mahar, Jonathan D. Cherry, Victor E. Alvarez, Brigid Dwyer, Bertrand R. Huber, Thor D. Stein, Lee E. Goldstein, Douglas I. Katz, Robert C. Cantu, Rhoda Au, Neil W. Kowall, Robert A. Stern, Michael D. McClean, Jennifer Weuve, Yorghos Tripodis, Ann C. McKee,
Objective Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to contact and collision sports, including American football. We hypothesized a dose–response relationship between duration of football played and CTE risk and severity. Methods In a convenience sample of 266 deceased American football players from the Veterans Affairs–Boston University–Concussion Legacy Foundation and Framingham Heart Study Brain Banks, we estimated the association of years of ...
Tópico(s): Spinal Cord Injury Research
2019 - Wiley | Annals of Neurology
Michael L. Alosco, Jesse Mez, Yorghos Tripodis, Patrick T. Kiernan, Bobak Abdolmohammadi, Lauren Murphy, Neil W. Kowall, Thor D. Stein, Bertrand R. Huber, Lee E. Goldstein, Robert C. Cantu, Douglas I. Katz, Christine E. Chaisson, Brett Martin, Todd M. Solomon, Michael D. McClean, Daniel H. Daneshvar, Christopher J. Nowinski, Robert A. Stern, Ann C. McKee,
To examine the effect of age of first exposure to tackle football on chronic traumatic encephalopathy (CTE) pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically confirmed CTE.The sample included 246 tackle football players who donated their brains for neuropathological examination. Two hundred eleven were diagnosed with CTE (126 of 211 were without comorbid neurodegenerative diseases), and 35 were without CTE. Informant interviews ascertained ...
Tópico(s): Cardiac Arrest and Resuscitation
2018 - Wiley | Annals of Neurology
Xiyuan Lu, Ashley Solmonson, Alessia Lodi, Sara M. Nowinski, Enrique Sentandreu, Christopher L. Riley, Edward Mills, Stefano Tiziani,
Abstract To maintain core body temperature in cold conditions, mammals activate a complex multi-organ metabolic response for heat production. White adipose tissue (WAT) primarily functions as an energy reservoir, while brown adipose tissue (BAT) is activated during cold exposure to generate heat from nutrients. Both BAT and WAT undergo specific metabolic changes during acute cold exposure. Here, we use an untargeted metabolomics approach to characterize the initial metabolic response to cold exposure ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2017 - Nature Portfolio | Scientific Reports
Jennifer M. Coughlin, Yuchuan Wang, Il Minn, Nicholas Bienko, Emily B. Ambinder, Xin Xu, Matthew E. Peters, John W. Dougherty, Melin Vranešić, Soo Min Koo, Hye-Hyun Ahn, Merton Lee, C.A. Cottrell, Haris I. Sair, Akira Sawa, Cynthia A. Munro, Christopher J. Nowinski, Robert F. Dannals, Constantine G. Lyketsos, Michael Kassiou, Gwenn S. Smith, Brian Caffo, Susumu Mori, Tomás R. Guilarte, Martin G. Pomper,
Microglia, the resident immune cells of the central nervous system, play an important role in the brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single and repeated traumatic brain injury, possibly through sports-related concussive and subconcussive injuries. Limited in vivo brain imaging studies months to years after individuals experience a single moderate to severe traumatic brain injury suggest widespread persistent ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2016 - American Medical Association | JAMA Neurology
Philip H. Montenigro, Michael L. Alosco, Brett Martin, Daniel H. Daneshvar, Jesse Mez, Christine E. Chaisson, Christopher J. Nowinski, Rhoda Au, Ann C. McKee, Robert C. Cantu, Michael D. McClean, Robert A. Stern, Yorghos Tripodis,
The term “repetitive head impacts” (RHI) refers to the cumulative exposure to concussive and subconcussive events. Although RHI are believed to increase risk for later-life neurological consequences (including chronic traumatic encephalopathy), quantitative analysis of this relationship has not yet been examined because of the lack of validated tools to quantify lifetime RHI exposure. The objectives of this study were: 1) to develop a metric to quantify cumulative RHI exposure from football, which ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2016 - Mary Ann Liebert, Inc. | Journal of Neurotrauma
Michael L. Alosco, Jesse Mez, Neil W. Kowall, Thor D. Stein, Lee E. Goldstein, Robert C. Cantu, Douglas I. Katz, Todd M. Solomon, Patrick T. Kiernan, Lauren Murphy, Bobak Abdolmohammadi, Daniel H. Daneshvar, Philip H. Montenigro, Christopher J. Nowinski, Robert A. Stern, Ann C. McKee,
This study conducted a preliminary examination on cognitive reserve (CR) as a modifier of symptom expression in subjects with autopsy-confirmed chronic traumatic encephalopathy (CTE). The sample included 25 former professional football players neuropathologically diagnosed with CTE stage III or IV. Next of kin interviews ascertained age at cognitive and behavioral/mood symptom onset and demographic/athletic characteristics. Years of education and occupational attainment defined CR. High occupational ...
Tópico(s): Cardiac Arrest and Resuscitation
2016 - American Psychiatric Association Publishing | Journal of Neuropsychiatry
Laura C. Politte, Yamini J. Howe, Lisa A. Nowinski, Michelle Palumbo, Christopher J. McDougle,
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders that manifest in early childhood and persist throughout the lifespan; treatment should reflect the unique challenges for that individual at each developmental stage. In early childhood, treatment should focus on the acquisition of language, play skills, joint attention, and effective communication strategies through intensive behavioral and educational interventions, particularly Applied Behavioral Analysis ( ...
Tópico(s): Family and Disability Support Research
2015 - Springer Science+Business Media | Current Treatment Options in Psychiatry
Thor D. Stein, Philip H. Montenigro, Victor E. Alvarez, Weiming Xia, John F. Crary, Yorghos Tripodis, Daniel H. Daneshvar, Jesse Mez, Todd M. Solomon, Gaoyuan Meng, Caroline A. Kubilus, Kerry A. Cormier, Steven Meng, Katharine J. Babcock, Patrick T. Kiernan, Lauren Murphy, Christopher J. Nowinski, Brett Martin, Diane Dixon, Robert A. Stern, Robert C. Cantu, Neil W. Kowall, Ann C. McKee,
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. It is defined pathologically by the abnormal accumulation of tau in a unique pattern that is distinct from other tauopathies, including Alzheimer’s disease (AD). Although trauma has been suggested to increase amyloid β peptide (Aβ) levels, the extent of Aβ deposition in CTE has not been thoroughly characterized. We studied a heterogeneous cohort of deceased athletes and military ...
Tópico(s): Neurological and metabolic disorders
2015 - Springer Science+Business Media | Acta Neuropathologica
Alexander P. Lin, Saadallah Ramadan, Robert A. Stern, Hayden C. Box, Christopher J. Nowinski, Brian D. Ross, Carolyn E. Mountford,
The goal was to identify which neurochemicals differ in professional athletes with repetitive brain trauma (RBT) when compared to healthy controls using a relatively new technology, in vivo Localized COrrelated SpectroscopY (L-COSY).To achieve this, L-COSY was used to examine five former professional male athletes with 11 to 28 years of exposure to contact sports. Each athlete who had had multiple symptomatic concussions and repetitive sub concussive trauma during their career was assessed by an experienced ...
Tópico(s): Traumatic Brain Injury Research
2015 - BioMed Central | Alzheimer s Research & Therapy
Micah O. Mazurek, Benjamin L. Handen, Ericka L. Wodka, Lisa A. Nowinski, Eric Butter, Christopher R. Engelhardt,
This study sought to identify factors that may be associated with delays in autism spectrum disorder (ASD) diagnosis, including birth cohort, sociodemographic characteristics, and clinical features.Participants included 1716 children and adolescents with ASD enrolled in the Autism Speaks Autism Treatment Network (AS-ATN) between the years 2008 and 2011. Data were collected at enrollment using AS-ATN parent- and clinician-report forms and standardized measures of I.Q., ASD symptoms, adaptive function, ...
Tópico(s): Virology and Viral Diseases
2014 - Lippincott Williams & Wilkins | Journal of Developmental & Behavioral Pediatrics
Ann C. McKee, Thor D. Stein, Christopher J. Nowinski, Robert A. Stern, Daniel H. Daneshvar, Victor E. Alvarez, Hyo-Soon Lee, Garth F. Hall, Sydney M. Wojtowicz, Christine M. Baugh, David Riley, Caroline A. Kubilus, Kerry A. Cormier, Matthew A. Jacobs, Brett Martin, Carmela R. Abraham, Tsuneya Ikezu, R. Ross Reichard, Benjamin Wolozin, Andrew E. Budson, Lee E. Goldstein, Neil W. Kowall, Robert C. Cantu,
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury.We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging in age from 17 to 98 years (mean 59.5 years), including 64 athletes, 21 military veterans (86% of whom were also athletes) and one individual who engaged in ...
Tópico(s): Alzheimer's disease research and treatments
2012 - Oxford University Press | Brain
Lee E. Goldstein, Andrew M. Fisher, Chad A. Tagge, Xiaolei Zhang, Libor Velı́šek, John Sullivan, Chirag Upreti, Jonathan M. Kracht, Maria Ericsson, Mark Wojnarowicz, Cezar Goletiani, Giorgi Maglakelidze, Noel Casey, Juliet A. Moncaster, Olga Minaeva, Robert D. Moir, Christopher J. Nowinski, Robert A. Stern, Robert C. Cantu, James Geiling, Jan Krzysztof Blusztajn, Benjamin Wolozin, Tsuneya Ikezu, Thor D. Stein, Andrew E. Budson, Neil W. Kowall, David Chargin, André Sharon, Sudad Saman, Garth F. Hall, William C. Moss, Robin O. Cleveland, Rudolph E. Tanzi, Patric K. Stanton, Ann C. McKee,
Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans and experimental animals.
Tópico(s): Cardiac Arrest and Resuscitation
2012 - American Association for the Advancement of Science | Science Translational Medicine